@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1417: (2015-12-07 )
MIYTVTLNPSIDFIVRLDTLLLGSVNRMTSDDKYVGGKGINVSRILKRLKIDNTATGFIGGFTGHFVEDGLVSEGIKTDFVSVNEDTRINVKVKAKIETEINGGGPRITNEQLHRLEKLLSRLTPEDTVVFAGSAPASLGNKVYNTLIPIAKKTGAEVVCDFEGQTLLDALAYQPLLVKPNNHELADIFGVELEGLPDIEKYAHKILDKGAKNVIVSMAGDGALLVTPEASYFAKPIKGEVKNSVGAGDSMVAGFTGEFVKSKNPVEALKWGVACGTATTFSDDLATAEFIQDIYNKVEVEKL
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90.....-...100-.........110--..----.....----..120-......-...130.......140.......150.......160....---...170-.--.-...-...180.......190.-..-.-...200.......210........220.......230.......240.......250.......260.......270....--...280.--.--.....290.......300.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
Y
T
V
TLNPS
I
D
F
I
V
R
L
D
T
L
L
L
G
S
V
NRMTSDDKYVGGKGI
N
V
S
R
I
L
K
R
LKIDNTATGFIGGFT
G
H
F
V
ED
G
L
V
SEGIKT
D
F
V
SVNED
T
R
I
N
V
K
V
K
A
K
-
I
E
T
E
---INGGGPRI
T
N
----
E
Q
----
L
H
R
L
E
----
K
L
L
---
S
RLTPE-
D
T
V
V
F
AGSA
P
A
S
L
G
N
K
V
Y
N
T
L
IPIAKKTG
A
E
V
V
C
DFE
G
Q
T
---
L
L
D
A
L--A--Y-Q
P
L
-
L
VKPNNH
E
L
A
D
I
F
G
V
EL-EG-L-P
D
I
E
K
Y
A
H
K
I
L
DKG-A
K
N
V
I
V
S
MAGD
G
A
L
L
VTP
E
A
S
YFAKPIK
G
E
VKNSVGAGD
S
M
V
AGFT
G
E
F
VKSKN
P
V
E
A
L
K
W
GVACG--TATTFSD--D--
L
A
T
A
E
F
I
Q
D
I
Y
N
K
V
EVEKL
2
PsiBlast_PDB
96.34
43%
-82
- C2 -
2ABQ
3
?
A:
[2-299]
-
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
N
F
Q
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
I
E
V
E
G
D
T
R
I
N
V
K
I
K
G
K
-
Q
E
T
E
---
L
N
G
T
A
P
L
I
K
K
----
E
H
----
V
Q
A
L
L
----
E
Q
L
---
T
E
L
E
K
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
--
A
--
A
-
K
P
S
-
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
-
A
S
-
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
--
S
A
T
A
F
S
D
--
G
--
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
T
I
K
1
PsiBlast_PDB
96.08
44%
-90
- C2 -
2JG5
-
?
A:
[1-303]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
D
F
K
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
I
E
V
D
E
D
T
R
I
N
V
K
L
K
T
G
-
Q
E
T
E
---
I
N
A
P
G
P
H
I
T
S
----
T
Q
----
F
E
Q
L
L
----
Q
Q
I
---
K
N
T
T
S
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
--
P
--
Y
-
H
P
L
-
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
-
N
S
-
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
--
T
A
T
A
F
D
E
--
D
--
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
78
HHSearch
95.81
44%
-81
- C2 -
2ABQ
3
?
A:
[1-298]
M
I
Y
T
V
T
L
N
P
S
I
D
Y
I
V
Q
V
E
N
F
Q
Q
G
V
V
N
R
S
E
R
D
R
K
Q
P
G
G
K
G
I
N
V
S
R
V
L
K
R
L
G
H
E
T
K
A
L
G
F
L
G
G
F
T
G
A
Y
V
R
N
A
L
E
K
E
E
I
G
L
S
F
I
E
V
E
G
D
T
R
I
N
V
K
I
K
G
K
-
Q
E
T
E
---
L
N
G
T
A
P
L
I
K
K
----
E
H
----
V
Q
A
L
L
E
Q
L
-
T
E
L
---
E
K
---
G
-
D
V
L
V
L
A
G
S
V
P
Q
A
M
P
Q
T
I
Y
R
S
M
T
Q
I
A
K
E
R
G
A
F
V
A
V
D
T
S
G
E
A
---
L
H
E
V
L
--
A
--
A
-
K
P
S
-
F
I
K
P
N
H
H
E
L
S
E
L
V
S
K
P
I
-
A
S
-
I
-
E
D
A
I
P
H
V
Q
R
L
I
G
E
G
-
I
E
S
I
L
V
S
F
A
G
D
G
A
L
F
A
S
A
E
G
M
F
H
V
N
V
P
S
G
E
V
R
N
S
V
G
A
G
D
S
V
V
A
G
F
L
A
A
L
Q
E
G
K
S
L
E
D
A
V
P
F
A
V
A
A
G
--
S
A
T
A
F
S
D
--
G
--
F
C
T
R
E
E
V
E
R
L
Q
Q
Q
L
Q
R
T
I
K
73
HHSearch
94.79
44%
-89
- C2 -
2JG5
-
?
A:
[1-303]
M
I
Y
T
V
T
F
N
P
S
I
D
Y
V
I
F
T
N
D
F
K
I
D
G
L
N
R
A
T
A
T
Y
K
F
A
G
G
K
G
I
N
V
S
R
V
L
K
T
L
D
V
E
S
T
A
L
G
F
A
G
G
F
P
G
K
F
I
I
D
T
L
N
N
S
A
I
Q
S
N
F
I
E
V
D
E
D
T
R
I
N
V
K
L
K
T
G
-
Q
E
T
E
---
I
N
A
P
G
P
H
I
T
S
----
T
Q
----
F
E
Q
L
L
----
Q
Q
I
K
N
T
T
S
---
E
-
D
I
V
I
V
A
G
S
V
P
S
S
I
P
S
D
A
Y
A
Q
I
A
Q
I
T
A
Q
T
G
A
K
L
V
V
D
A
E
K
E
L
---
A
E
S
V
L
-----
P
Y
H
P
L
-
F
I
K
P
N
K
D
E
L
E
V
M
F
N
T
T
V
-
N
S
-
D
-
A
D
V
I
K
Y
G
R
L
L
V
D
K
G
-
A
Q
S
V
I
V
S
L
G
G
D
G
A
I
Y
I
D
K
E
I
S
I
K
A
V
N
P
Q
G
K
V
V
N
T
V
G
S
G
D
S
T
V
A
G
M
V
A
G
I
A
S
G
L
S
I
E
K
A
F
Q
Q
A
V
A
C
G
--
T
A
T
A
F
D
E
--
D
--
L
A
T
R
D
A
I
E
K
I
K
S
Q
V
T
I
S
V
L
76
HHSearch
87.85
32%
-75
* C2 *
2F02
1
LACC_ENTFA
A:
[3-313]
L
I
V
T
V
T
M
N
P
S
I
D
I
S
Y
L
L
D
H
L
K
L
D
T
V
N
R
T
S
Q
V
T
K
T
P
G
G
K
G
L
N
V
T
R
V
I
H
D
L
G
G
D
V
I
A
T
G
V
L
G
G
F
H
G
A
F
I
A
N
E
L
K
K
A
N
I
P
Q
A
F
T
S
I
K
E
E
T
R
D
S
I
A
I
L
H
E
G
N
Q
T
E
---
I
L
E
A
G
P
T
V
S
P
----
E
E
----
I
S
N
F
L
E
N
F
D
Q
L
I
---
K
Q
---
A
-
E
I
V
T
I
S
G
S
L
A
K
G
L
P
S
D
F
Y
Q
E
L
V
Q
K
A
H
A
Q
E
V
K
V
L
L
D
T
S
G
D
S
---
L
R
Q
V
L
--
Q
GP
W
-
K
P
Y
-
L
I
K
P
N
L
E
E
L
E
G
L
L
G
Q
D
F
-
S
E
N
P
L
A
A
V
Q
T
A
L
T
K
P
M
F
A
G
-
I
E
W
I
V
I
S
L
G
K
D
G
A
I
A
K
H
H
D
Q
F
Y
R
V
K
I
P
T
I
Q
A
K
N
P
V
G
S
G
D
A
T
I
A
G
L
A
Y
G
L
A
K
D
A
P
A
A
E
L
L
K
W
G
M
A
A
G
--
M
A
N
A
Q
E
R
--
M
TG
H
V
D
V
E
N
V
K
K
H
L
M
N
I
Q
V
V
E
I
5
PsiBlast_PDB
87.50
32%
-81
- C2 -
2JGV
-
LACC_STAA8
A:
[22-327]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
H
E
G
Q
Q
T
E
---
I
L
E
Q
G
P
E
I
D
N
----
Q
E
A
A
G
F
I
K
H
F
E
----
Q
L
L
---
E
K
V
----
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
--
G
--
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
28
PsiBlast_CBE
85.89
31%
-79
- C2 -
3N1C
2
PFKB_ECOLI
B:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
--
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
----
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
7
PsiBlast_PDB
85.72
31%
-74
- C2 -
2JG1
2
LACC_STAA8
A:
[22-327]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
H
E
G
Q
Q
T
E
---
I
L
E
Q
G
P
E
I
D
N
----
Q
E
----
A
A
G
F
I
----
K
H
F
---
E
Q
M
M
E
K
V
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
--
G
--
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
74
HHSearch
85.65
32%
-74
- C2 -
2JG1
2
LACC_STAA8
A:
[21-330]
M
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
H
E
G
Q
Q
T
E
---
I
L
E
Q
G
P
E
I
D
N
Q
E
A
A
G
F
----
I
K
H
F
E
----
Q
M
M
---
E
K
---
V
-
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
L
Q
T
V
L
E
N
P
-----
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
-
D
E
S
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
--
M
L
N
A
Q
E
A
--
Q
TG
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
10
PsiBlast_PDB
85.57
31%
-79
- C2 -
3N1C
2
PFKB_ECOLI
A:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
30
PsiBlast_CBE
85.49
31%
-77
- C2 -
3UQE
5
PFKB_ECOLI
B:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
D
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
----
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
6
PsiBlast_PDB
85.38
32%
-74
- C2 -
2Q5R
-
LACC_STAAC
A:
[2-307]
-
I
L
T
L
T
L
N
P
S
V
D
I
S
Y
P
L
T
A
L
K
L
D
D
V
N
R
V
Q
E
V
S
K
T
A
G
G
K
G
L
N
V
T
R
V
L
A
Q
V
G
E
P
V
L
A
S
G
F
I
G
G
E
L
G
Q
F
I
A
K
K
L
D
H
A
D
I
K
H
A
F
Y
N
I
K
G
E
T
R
N
C
I
A
I
L
H
E
G
Q
Q
T
E
---
I
L
E
Q
G
P
E
I
D
N
----
Q
E
A
A
G
F
I
K
H
F
E
----
Q
L
L
---
E
K
V
----
E
A
V
A
I
S
G
S
L
P
K
G
L
N
Q
D
Y
Y
A
Q
I
I
E
R
C
Q
N
K
G
V
P
V
I
L
D
C
S
G
A
T
---
L
Q
T
V
L
E
N
P
--
Y
-
K
P
T
-
V
I
K
P
N
I
S
E
L
Y
Q
L
L
N
Q
P
L
D
E
S
-
L
-
E
S
L
K
Q
A
V
S
Q
P
L
F
E
G
-
I
E
W
I
I
V
S
L
G
A
Q
G
A
F
A
K
H
N
H
T
F
Y
R
V
N
I
P
T
I
S
V
L
N
P
V
G
S
G
D
S
T
V
A
G
I
T
S
A
I
L
N
H
E
N
D
H
D
L
L
K
K
A
N
T
L
G
M
L
N
A
Q
E
A
Q
T
--
G
--
Y
V
N
L
N
N
Y
D
D
L
F
N
Q
I
E
V
L
E
V
24
PsiBlast_CBE
85.30
31%
-74
- C2 -
3UMP
7
PFKB_ECOLI
B:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
----
14
PsiBlast_PDB
85.23
31%
-73
- C2 -
3UQE
4
PFKB_ECOLI
A:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
D
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
--
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
22
PsiBlast_CBE
85.16
31%
-78
- C2 -
3UQD
5
PFKB_ECOLI
C:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
-GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
13
PsiBlast_PDB
84.71
31%
-79
- C2 -
3UQD
6
PFKB_ECOLI
A:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
26
PsiBlast_CBE
84.43
31%
-77
- C2 -
3N1C
2
PFKB_ECOLI
D:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
29
PsiBlast_CBE
84.15
31%
-74
- C2 -
3CQD
7
PFKB_ECOLI
B:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
----
27
PsiBlast_CBE
84.04
31%
-77
- C2 -
3N1C
2
PFKB_ECOLI
C:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
11
PsiBlast_PDB
83.98
31%
-77
- C2 -
3UMO
7
PFKB_ECOLI
A:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
Q
Y
R
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
23
PsiBlast_CBE
83.87
31%
-78
- C2 -
3UQD
6
PFKB_ECOLI
B:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---
21
PsiBlast_CBE
83.77
31%
-76
- C2 -
3UQD
6
PFKB_ECOLI
D:
[4-304]
-
I
Y
T
L
T
L
A
P
S
L
D
S
A
T
I
T
P
Q
I
Y
P
E
G
K
L
R
C
T
A
P
V
F
E
P
G
G
G
G
I
N
V
A
R
A
I
A
H
L
G
G
S
A
T
A
I
F
P
A
G
G
A
T
G
E
H
L
V
S
L
L
A
D
E
N
V
P
V
A
T
V
E
A
K
D
W
T
R
Q
N
L
H
V
H
V
E
-
A
S
G
E
QYR
F
V
M
P
G
A
A
L
N
E
----
D
E
----
F
R
Q
L
E
----
E
Q
V
---
L
E
I
E
S
G
-
A
I
L
V
I
S
G
S
L
P
P
G
V
K
L
E
K
L
T
Q
L
I
S
A
A
Q
K
Q
G
I
R
C
I
V
D
S
S
G
E
A
---
L
S
A
A
L
--
A
--
I
-
G
N
I
E
L
V
K
P
N
Q
K
E
L
S
A
L
V
N
R
E
L
-
T
Q
-
P
-
D
D
V
R
K
A
A
Q
E
I
V
N
S
G
K
A
K
R
V
V
V
S
L
G
P
Q
G
A
L
G
V
D
S
E
N
C
I
Q
V
V
P
P
P
V
K
S
Q
S
T
V
G
A
G
D
S
M
V
G
A
M
T
L
K
L
A
E
N
A
S
L
E
E
M
V
R
F
G
V
A
A
G
--
S
A
A
T
L
N
Q
GT
R
--
L
C
S
H
D
D
T
Q
K
I
Y
A
Y
L
S
R
---