@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1419: (2015-12-07 )
MTLRELTIEEFKEHSGNYDSQSFLQTPEMAKLLEKRGYDVRYLGYQVENKLEIISLSYIMPVTGGFQMKIDSGPVHSNSKYLKQFYKALQGYAKSNGVLELIVEPYDDYQLFTSSGVPSNQGNDNLIEDFTSSGYHHDGLTTGFTGKYLSWHYVKNLEGVTSETLLSSFSKTGRALVKKAMSFGIKVRVLKRDELHLFKEITTSTSNRRDYMDKSLDYYQDFYDSFEGKAEFVIATLNFREYDHNLQIKAEALENKLKLLDERFRENADSPKYHRQRSEIINQLASFETRRQEVQSFIQKYDNQDVVLAGSLFVYSLKETVYFFSGSYTEFNKFYAPAVLQEYVMQEALKRGSTFYNLLGIQGTFDGSDSILRFKQNFNGYIIRKMGTFNYYPSPFKYKGIQLLKKVLKRN
Atome Classification :
(20 SA)
-....---...-..10........20........30........40....-....50...-....-.60-....--....70.....--.-...80-.........90.....---.--..100.......110....-...120.......130.......140---..-...-..150........160-.-.......170.....-..180.------.....---.-190-.........200.......210.--....-..220....-..-.230.......240.......250.......260.----------......270..-......280.......290.......300.......310....------..-------.320.......330.......340.......350.-.......360......-.---370.......380.-.......390........400.......410------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
T
L
R
---
E
L
T
-
I
E
E
F
K
E
HSGNYD
S
Q
S
F
LQ
T
P
E
M
A
K
L
L
E
KRGY
D
V
R
Y
L
G
Y
-
Q
VEN
K
L
E
I
I
-
S
L
S
Y
-
I
M
P-VTG
G
--
F
Q
M
K
I-DSGPV--H-S
N
S
K
--
Y
L
K
Q
F
Y
K
A
L
Q
G
Y
AKSN---
G
--
V
L
E
L
I
VEPYDD
Y
Q
L
FTSSG-VPSNQGN
D
N
L
I
E
D
F
T
SSGYHHDGLTT---GF-TGK-
Y
L
S
-
W
H
Y
VKNLEG
V
T
--
S
-
E
T
L
L
S
S
F
S
K
T
G
R
A
L
V
-
K
K
A
M
SF------G
I
K
V
R
---
V
-
L
---KRD
E
L
H
L
F
K
E
I
TTSTSN
R
R
D
Y
M
D
--
K
S
L
D
-
Y
Y
Q
D
F
Y
D
SF-EG-K
A
E
F
V
I
A
T
L
N
FREYDHN
L
Q
I
K
A
E
A
L
E
N
K
L
K
L
L
D
E
R
----------
F
RENADS-
P
K
Y
-
H
R
Q
R
S
E
I
I
N
Q
L
A
S
F
E
T
R
R
Q
E
V
Q
S
F
I
Q
KYDNQ
D
V
V
L
AG
S
L
F
V
Y
S
------L
K
-------
E
T
V
Y
F
FSGSY
T
E
F
N
K
FY
A
P
A
V
L
Q
E
Y
V
M
Q
E
A
L
KR-G-S
T
F
Y
N
L
L
GI
Q
G
TFDGS-
D
---
S
I
L
R
F
KQNFN
G
Y
-
I
-
I
R
K
MGTFNY-YPSPFK
Y
K
G
I
Q
L
L
K
K
V
LKRN-------------
42
Fugue
96.91
24%
-77
- C2 -
1LRZ
-
FEMA_STAAU
A:
[1-412]
-
M
K
F
T
---
N
L
T
-
A
K
E
F
G
A
F
T
D
S
M
P
Y
S
H
F
T
Q
T
V
G
H
Y
E
L
K
L
A
E
G
Y
E
T
H
L
V
G
I
-
K
N
N
N
N
E
V
I
A
-
A
C
L
L
-
T
A
V
-
P
V
M
K
V
F
K
Y
F
Y
S
-
N
R
G
P
V
ID
Y
-
E
N
Q
E
--
L
V
H
F
F
F
N
E
L
S
K
Y
V
K
K
H
---
R
--
C
L
Y
L
H
I
D
P
Y
L
P
Y
Q
Y
L
N
H
D
G
E
I
T
G
N
A
G
N
D
W
F
F
D
K
M
S
N
L
G
F
E
H
T
G
F
H
K
---
G
F
-
D
P
V
-
L
Q
I
R
Y
H
S
V
L
D
L
K
D
K
T
--
A
-
D
D
I
I
K
N
M
D
G
L
R
K
R
N
T
-
K
K
V
K
K
N
------
G
V
K
V
R
---
F
-
L
---
S
E
E
E
L
P
I
F
R
S
F
M
D
--------------
D
K
-
F
Y
Y
N
R
L
K
Y
Y
-
K
D
-
R
V
L
V
P
L
A
Y
I
N
F
D
E
Y
I
K
E
L
N
E
E
R
D
I
L
N
K
D
L
N
K
A
L
K
D
----------
I
E
K
R
P
E
N
-
K
K
A
-
H
N
K
R
D
N
L
Q
Q
Q
L
D
A
N
E
Q
K
I
E
E
G
K
R
L
Q
E
E
H
G
N
-
E
L
P
I
S
A
G
F
F
F
I
N
------
P
F
-------
E
V
V
Y
Y
A
G
G
T
S
N
A
F
R
H
F
A
G
S
Y
A
V
Q
W
E
M
I
N
Y
A
L
N
H
-
G
-
I
D
R
Y
N
F
Y
G
V
S
G
K
F
T
E
D
-
A
ED
A
G
V
V
K
F
K
K
G
Y
N
A
E
-
I
-
I
E
Y
V
G
D
F
I
K
-
P
I
N
K
P
V
Y
A
A
Y
T
A
L
--------------------
43
Fugue
69.78
16%
-58
- C2 -
1P4N
6
FEMX_WEIVI
A:
[1-335]
-
P
V
L
N
LND
P
Q
A
-
V
E
R
Y
E
E
F
M
R
Q
S
P
Y
G
Q
V
T
Q
D
L
G
W
A
K
V
--
K
N
N
W
E
P
V
D
V
Y
L
E
D
D
Q
G
A
I
I
A
A
-
M
S
M
L
-
L
G
D
-
T
P
T
D
--
K
K
F
A
Y
A
S
K
G
P
V
MD
V
-
T
D
V
D
--
L
L
D
R
L
V
D
E
A
V
K
A
L
D
G
R
---
A
--
Y
V
L
R
F
-----------
D
P
E
-
V
A
Y
S
D
E
F
N
T
T
L
Q
D
H
G
Y
V
T
R
N
R
N
V
A
D
A
---
G
M
-
H
A
T
I
Q
P
R
-
L
N
M
V
L
D
L
T
K
F
P
--
D
A
K
T
T
L
D
L
Y
P
S
K
T
K
S
K
I
-
K
R
P
F
R
D
------
G
V
E
V
H
---
S
G
N
---
S
A
T
E
L
D
E
F
F
K
T
Y
T
T
M
A
E
R
H
G
I
T
H
--
R
P
I
E
-
Y
F
Q
R
M
Q
A
A
F
D
A
D
-
T
M
R
I
F
V
A
E
R
E
------------------------------------------------------------------------------
G
K
L
L
S
T
G
I
A
L
K
Y
------
G
R
-------
K
I
W
Y
M
Y
A
G
S
M
D
G
N
T
Y
-
Y
A
P
Y
A
V
Q
S
E
M
I
Q
W
A
L
D
T
-
N
-
T
D
L
Y
D
L
G
G
I
E
S
E
-
S
T
D
-
D
---
S
L
Y
V
F
K
H
V
F
V
K
D
A
P
-
R
E
Y
I
G
E
I
D
K
-
V
L
D
P
E
V
Y
A
E
L
-------
V
K
D
-------------
22
HHSearch
68.30
18%
-65
* C2 *
3GKR
6
FEMX_WEIVI
A:
[7-334]
---
N
D
---
P
Q
A
-
V
E
R
Y
E
E
F
M
R
Q
S
P
Y
G
Q
V
T
Q
D
L
G
W
A
K
V
K
N
--
N
W
E
P
V
D
V
Y
L
-
E
D
D
Q
G
A
I
I
A
A
M
S
M
L
-
L
G
D
T
P
T
D
K
--
K
F
A
Y
A
-
S
K
G
P
V
--
M
-
D
V
T
D
V
D
L
L
D
R
L
V
D
E
A
V
K
A
L
D
G
----
R
--
A
Y
V
L
R
F
D
P
E
V
A
Y
S
--------------
D
E
F
N
T
T
L
Q
D
H
G
Y
V
T
R
N
R
N
V
A
D
A
G
M
H
A
T
I
-
Q
P
R
-
L
N
M
V
L
D
L
T
K
-
F
PD
A
-
K
T
T
L
D
L
Y
P
S
K
T
K
S
K
I
-
K
R
P
F
R
D
------
G
V
E
V
H
---
S
-
G
N
--
S
A
T
E
L
D
E
F
F
K
T
Y
T
T
M
A
E
R
H
G
I
T
H
--
R
P
I
E
-
Y
F
Q
R
M
Q
A
A
F
-
D
A
D
T
M
R
I
F
V
A
E
R
------------------------------------------------------------------------------
E
G
K
L
L
S
T
G
I
A
L
K
Y
------
G
R
-------
K
I
W
Y
M
Y
A
G
S
M
D
G
-
N
T
Y
Y
A
P
Y
A
V
Q
S
E
M
I
Q
W
A
L
D
T
-
N
-
T
D
L
Y
D
L
G
G
I
E
S
E
S
T
-
D
-
D
---
S
L
Y
V
F
K
H
V
F
V
K
D
-
A
P
R
E
Y
I
G
E
I
D
K
-
V
L
D
P
E
V
Y
A
E
L
V
K
D
--------------------
23
HHSearch
48.14
12%
-43
- C2 -
2HQY
1
?
A:
[63-285]
--------------------------------------------------------------------------------
A
-
Y
M
M
P
V
--
G
-
N
G
D
----
L
K
A
V
L
R
K
L
I
E
D
A
D
K
E
---
K
H
N
F
C
M
L
G
V
C
S
N
M
R
A
--------------------
D
L
E
A
I
L
P
E
R
F
I
F
--------
T
E
D
-
R
A
Y
-
A
D
Y
I
Y
L
R
S
D
----
L
-
A
T
L
K
G
K
K
F
Q
A
K
R
N
H
I
-
N
R
F
R
N
T
Y
P----
D
Y
E
Y
T
---
P
-
I
TPD
R
I
Q
E
C
L
D
L
E
A
E
W
C
K
V
N
N
C
D
Q
Q
E
G
T
G
N
E
R
R
-
A
L
I
Y
A
L
H
N
F
-
E
A
L
G
L
T
G
G
I
L
H
V
------------------------------------------------------------------------------
N
G
K
I
V
A
F
T
F
G
M
P
I
N-----
H
E
-------
T
F
G
V
H
V
E
K
A
D
T
S
--
I
D
G
A
Y
A
M
I
N
Y
E
F
A
N
R
I
-
P
E
-
Q
-
Y
I
Y
I
N
R
E
E
D
L
G
I
-----
E
---
G
L
R
K
A
K
L
S
Y
Q
P
V
-
T
-
I
L
E
K
Y
M
A
C
L
-
K
D
H
------------------------------
9
PsiBlast_PDB
48.02
21%
-38
- C2 -
3THX
2
MSH3_HUMAN
B:
[466-601]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
H
Y
L
K
I
L
N
E
Q
A
A
K
V
GDKTEL
F
K
D
L
S
D
F
-
P
L
I
-
K
K
R
K
D
E
I
Q
G
V
I
D
E
I
R
M
H
L
Q
E
I
R
K
I
L
K
N
P
S
A
Q
Y
V
T
V
S
G
Q
E
F
M
I
E
------
I
K
NSAVSCI
P
T
D
W
V
K
V
G
S
T
K
A
V
S
R
F
H
S
P
F
I
V
E
N
Y
------------
R
H
L
N
Q
L
R
E
Q
L
V
L
D
C
S
-
A
---
E
W
L
D
F
L
E
K
F
S
E
H
-
Y
-
H
S
L
C
K
A
V
H
H
-
L
A
T
V
D
C
I
F
S
L
A
K
V
A
K
Q
G
D
Y
C
-------------
47
Fugue
47.26
14%
-22
- C2 -
3TNF
4
?
B:
[3-381]
-
L
D
E
Y
---
E
Q
A
-
I
K
R
A
Q
E
N
------------
I
K
K
G
E
E
L
E
K
K
L
D
K
L
E
R
Q
G
K
-
D
L
E
D
K
Y
K
T
Y
-
E
E
N
L
-
E
------
G
--
F
E
K
L
L
-
T
D
S
E
E
--
L
-
S
------
L
S
E
I
N
E
K
M
E
A
F
S
K
D
S
---
E
--
K
L
T
Q
L
M
E
K
H
K
G
-------
D
-
E
K
T
V
Q
S
L
Q
R
E
H
H
D
I
K
A
K
L
A
N
L
Q
V
L
H
D
---
A
H
-
T
G
K
-
K
----
S
Y
V
N
E
K
G
N
P
V
--
S
-
S
------------
L
K
-
D
A
H
L
A
I
------
N
K
D
Q
E
---
V
-
V
---
E
H
E
G
Q
F
Y
L
L
Q
K
G
Q
W
D
A
I
K
N
N
--
P
--
A
A
L
E
-
K
A
Q
K
D
Y
S
Q
S
-
K
H
-
D
L
A
T
I
K
M
E
A
L
I
H
K
L
S
L
E
M
E
K
Q
L
E
T
I
N
N
L
I
M
S
T
D
P
K
----------
E
N
E
E
A
T
K
-
L
L
H
K
H
N
G
L
N
L
K
L
A
N
L
Q
D
M
L
A
V
H
R
K
E
K
S
F
F
N
E
K
G
E
E
V
T
S
L
N
D
A
H
Y
V
I
G
------
K
D
-------
Q
Q
L
F
N
L
G
G
K
F
Y
P
I
H
K
--
E
Q
K
I
L
E
K
D
G
K
F
Y
L
L
K
Q
-
G
-
E
D
W
E
S
I
K
D
S
P
E
K
Q
K
K
A
-
E
---
H
D
F
H
K
L
Q
Y
E
T
P
M
-
T
-
V
K
K
L
V
H
H
N
K
G
L
E
T
T
I
H
K
E
R
V
E
E
T
K
Q
Q
L
E
D
N
G
K
E
K
I
E
I
A
N
N
I
S
K
10
PsiBlast_PDB
47.15
21%
-37
- C2 -
3THY
1
MSH3_HUMAN
B:
[466-601]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
H
Y
L
K
I
L
N
E
Q
A
A
K
V
GDKTEL
F
K
D
L
S
D
F
-
P
L
I
-
K
K
R
K
D
E
I
Q
G
V
I
D
E
I
R
M
H
L
Q
E
I
R
K
I
L
K
N
P
S
A
Q
Y
V
T
V
S
G
Q
E
F
M
I
E
------
I
K
NSAVSCI
P
T
D
W
V
K
V
G
S
T
K
A
V
S
R
F
H
S
P
F
I
V
E
N
Y
------------
R
H
L
N
Q
L
R
E
Q
L
V
L
D
C
S
-
A
---
E
W
L
D
F
L
E
K
F
S
E
H
-
Y
-
H
S
L
C
K
A
V
H
H
-
L
A
T
V
D
C
I
F
S
L
A
K
V
A
K
Q
G
D
Y
C
-------------
11
PsiBlast_PDB
45.70
21%
-26
- C2 -
3THZ
1
MSH3_HUMAN
B:
[466-601]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
H
Y
L
K
I
L
N
E
Q
A
A
K
V
GDKTEL
F
K
D
L
S
D
F
-
P
L
I
-
K
K
R
K
D
E
I
Q
G
V
I
D
E
I
R
M
H
L
Q
E
I
R
K
I
L
K
N
P
S
A
Q
Y
V
T
V
S
G
Q
E
F
M
I
E
------
I
K
NSAVSCI
P
T
D
W
V
K
V
G
S
T
K
A
V
S
R
F
H
S
P
F
I
V
E
N
Y
------------
R
H
L
N
Q
L
R
E
Q
L
V
L
D
C
S
-
A
---
E
W
L
D
F
L
E
K
F
S
E
H
-
Y
-
H
S
L
C
K
A
V
H
H
-
L
A
T
V
D
C
I
F
S
L
A
K
V
A
K
Q
G
D
Y
C
-------------
13
PsiBlast_PDB
45.53
23%
-21
- C3 -
1QCN
3
FAAA_MOUSE
A:
[52-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
T
G
P
-
A
L
S
-
K
H
-----
Q
H
V
F
--
D
-
E
T
T
L
N
N
F
M
G
L
G
Q
A
A
W
-
K
E
A
R
A
S
L
Q
N
L
L
S
A
S
Q
A
R
---
L
------
R
D
D
K
E
L
R
Q
R
A
F
T
S
Q
A
S
A
T
M
H
L
P
--
A
T
I
G
-
D
Y
T
D
F
Y
S
S
----------------
R
Q
H
A
T
N
V
G
I
M
F
R
G
K
E
N
--
A
L
L
P
N
W
----------
L
H
L
P
V
----
G
Y
-
H
G
R
A
S
S
I
V
--
V
S
G
T
P
I
R
R
P
M
G
Q
M
---
R
P
D
N
S
K
P
P
V
Y
G
A
C
R
L
L
D
------
M
E
-------
L
E
M
A
F
F
V
G
P
G
N
R
F
G
E
P
I
P
I
S
K
A
H
E
H
I
F
G
M
V
L
M
N
-
D
-
W
S
A
R
D
I
Q
Q
W
E
Y
V
P
L
G
P
-
F
---
L
G
K
S
F
G
T
T
I
S
P
W
-
V
-
V
P
M
D
A
L
M
P
F
-
V
V
P
N
P
K
Q
D
P
K
P
L
P
Y
L
C
H
S
Q
P
-------------
16
PsiBlast_PDB
44.59
23%
-18
- C3 -
1QQJ
3
FAAA_MOUSE
A:
[50-214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
T
G
P
-
A
L
S
-
K
H
-----
Q
H
V
F
--
D
-
E
T
T
L
N
N
F
M
G
L
G
Q
A
A
W
-
K
E
A
R
A
S
L
Q
N
L
L
S
A
S
Q
A
R
---
L
------
R
D
D
K
E
L
R
Q
R
A
F
T
S
Q
A
S
A
T
M
H
L
P
--
A
T
I
G
-
D
Y
T
D
F
Y
S
S
----------------
R
Q
H
A
T
N
V
G
I
M
F
R
G
K
E
N
--
A
L
L
P
N
W
----------
L
H
L
P
V
G
----
Y
-
H
G
R
A
S
S
I
V
--
V
S
G
T
P
I
R
R
P
M
G
Q
---
M
R
P
D
N
S
K
P
P
V
Y
G
A
C
R
L
L
D
------
M
E
-------
L
E
M
A
F
F
V
G
P
G
N
R
F
G
E
P
I
P
I
S
K
A
H
E
H
I
F
G
M
V
L
M
N
-
D
-
W
S
A
R
D
I
Q
Q
W
E
Y
V
P
L
G
P
-
F
---
L
G
K
S
F
G
T
T
I
S
P
W
-
V
-
V
P
M
D
A
L
M
P
F
-
V
V
P
N
P
K
Q
D
P
K
P
L
P
Y
L
C
H
S
Q
P
-------------
8
PsiBlast_PDB
44.57
21%
-28
- C2 -
3THW
-
MSH3_HUMAN
B:
[466-601]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
H
Y
L
K
I
L
N
E
Q
A
A
K
V
GDKTEL
F
K
D
L
S
D
F
-
P
L
I
-
K
K
R
K
D
E
I
Q
G
V
I
D
E
I
R
M
H
L
Q
E
I
R
K
I
L
K
N
P
S
A
Q
Y
V
T
V
S
G
Q
E
F
M
I
E
------
I
K
NSAVSCI
P
T
D
W
V
K
V
G
S
T
K
A
V
S
R
F
H
S
P
F
I
V
E
N
Y
------------
R
H
L
N
Q
L
R
E
Q
L
V
L
D
C
S
-
A
---
E
W
L
D
F
L
E
K
F
S
E
H
-
Y
-
H
S
L
C
K
A
V
H
H
-
L
A
T
V
D
C
I
F
S
L
A
K
V
A
K
Q
G
D
Y
C
-------------
12
PsiBlast_PDB
42.60
23%
-17
- C3 -
1QCO
3
FAAA_MOUSE
A:
[52-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
T
G
P
-
A
L
S
-
K
H
-----
Q
H
V
F
--
D
-
E
T
T
L
N
N
F
M
G
L
G
Q
A
A
W
-
K
E
A
R
A
S
L
Q
N
L
L
S
A
S
Q
A
R
---
L
------
R
D
D
K
E
L
R
Q
R
A
F
T
S
Q
A
S
A
T
M
H
L
P
--
A
T
I
G
-
D
Y
T
D
F
Y
S
S
----------------
R
Q
H
A
T
N
V
G
I
M
F
R
G
K
E
N
--
A
L
L
P
N
W
----------
L
H
L
P
V
----
G
Y
-
H
G
R
A
S
S
I
V
--
V
S
G
T
P
I
R
R
P
M
G
Q
---
M
R
P
D
N
S
K
P
P
V
Y
G
A
C
R
L
L
D
------
M
E
-------
L
E
M
A
F
F
V
G
P
G
N
R
F
G
E
P
I
P
I
S
K
A
H
E
H
I
F
G
M
V
L
M
N
-
D
-
W
S
A
R
D
I
Q
Q
W
E
Y
V
P
L
G
P
-
F
---
L
G
K
S
F
G
T
T
I
S
P
W
-
V
-
V
P
M
D
A
L
M
P
F
-
V
V
P
N
P
K
Q
D
P
K
P
L
P
Y
L
C
H
S
Q
P
-------------
14
PsiBlast_PDB
42.02
23%
-17
- C3 -
1HYO
3
FAAA_MOUSE
A:
[52-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
T
G
P
-
A
L
S
-
K
H
-----
Q
H
V
F
--
D
-
E
T
T
L
N
N
F
M
G
L
G
Q
A
A
W
-
K
E
A
R
A
S
L
Q
N
L
L
S
A
S
Q
A
R
---
L
------
R
D
D
K
E
L
R
Q
R
A
F
T
S
Q
A
S
A
T
M
H
L
P
--
A
T
I
G
-
D
Y
T
D
F
Y
S
S
----------------
R
Q
H
A
T
N
V
G
I
M
F
R
G
K
E
N
--
A
L
L
P
N
W
----------
L
H
L
P
V
G
----
Y
-
H
G
R
A
S
S
I
V
--
V
S
G
T
P
I
R
R
P
M
G
Q
---
M
R
P
D
N
S
K
P
P
V
Y
G
A
C
R
L
L
D
------
M
E
-------
L
E
M
A
F
F
V
G
P
G
N
R
F
G
E
P
I
P
I
S
K
A
H
E
H
I
F
G
M
V
L
M
N
-
D
-
W
S
A
R
D
I
Q
Q
W
E
Y
V
P
L
G
P
-
F
---
L
G
K
S
F
G
T
T
I
S
P
W
-
V
-
V
P
M
D
A
L
M
P
F
-
V
V
P
N
P
K
Q
D
P
K
P
L
P
Y
L
C
H
S
Q
P
-------------
15
PsiBlast_PDB
41.98
23%
-15
* C3 *
2HZY
5
FAAA_MOUSE
A:
[52-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
T
G
P
-
A
L
S
-
K
H
-----
Q
H
V
F
--
D
-
E
T
T
L
N
N
F
M
G
L
G
Q
A
A
W
-
K
E
A
R
A
S
L
Q
N
L
L
S
A
S
Q
A
R
---
L
------
R
D
D
K
E
L
R
Q
R
A
F
T
S
Q
A
S
A
T
M
H
L
P
--
A
T
I
G
-
D
Y
T
D
F
Y
S
S
----------------
R
Q
H
A
T
N
V
G
I
M
F
R
G
K
E
N
--
A
L
L
P
N
W
----------
L
H
L
P
V
G
----
Y
-
H
G
R
A
S
S
I
V
--
V
S
G
T
P
I
R
R
P
M
G
Q
---
M
R
P
D
N
S
K
P
P
V
Y
G
A
C
R
L
L
D
------
M
E
-------
L
E
M
A
F
F
V
G
P
G
N
R
F
G
E
P
I
P
I
S
K
A
H
E
H
I
F
G
M
V
L
M
N
-
D
-
W
S
A
R
D
I
Q
Q
W
E
Y
V
P
L
G
P
-
F
---
L
G
K
S
F
G
T
T
I
S
P
W
-
V
-
V
P
M
D
A
L
M
P
F
-
V
V
P
N
P
K
Q
D
P
K
P
L
P
Y
L
C
H
S
Q
P
-------------
7
PsiBlast_PDB
40.40
31%
-35
- C2 -
1XF8
-
FEMX_WEIVI
A:
[252-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
W
F
M
Y
A
G
S
M
D
G
N
T
Y
Y
A
P
Y
A
V
Q
S
E
M
I
Q
W
A
L
D
T
-
N
-
T
D
L
Y
D
L
G
G
I
E
S
E
-
S
T
D
-
D
---
S
L
Y
V
F
K
H
V
F
V
K
D
-
A
-
P
R
E
Y
I
G
E
I
D
-
K
V
L
D
P
E
V
Y
A
E
L
V
K
D
-------------------
25
HHSearch
40.18
15%
-34
- C2 -
3DSB
3
?
A:
[63-144]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
K
V
V
A
Q
I
M
Y
T
Y
E
W
S
DWRN
G
N
-------
F
L
W
I
Q
S
V
Y
V
D
K
E
Y
R
R
K
G
I
F
N
Y
L
F
N
Y
I
K
N
I
C
D
K
D
E
N
-
I
V
G
M
R
L
Y
V
E
K
E
N
-----
I
---
N
A
K
A
T
Y
E
S
L
N
M
Y
-
E
-
C
D
Y
N
M
Y
E
Y
E
-
V
I
H
------------------------------
49
Fugue
39.33
9%
-5
- C1 -
3GYC
5
?
A:
[13-393]
E
I
S
P
R
---
A
I
T
M
W
D
-
F
S
W
L
E
R
R
W
P
G
A
G
Y
E
D
W
D
Q
V
L
D
E
L
S
E
R
G
Y
N
A
I
R
I
D
A
-
Y
----
P
H
L
I
-
A
E
N
P
M
K
K
W
-
L
L
K
E
--
V
W
N
Q
Q
-
D
W
G
S
P
--
D
M
N
E
V
Q
--
V
Q
P
N
L
N
L
F
L
S
K
C
K
E
R
D
I
K
V
G
--
L
S
S
W
Y
R
L
D
V
D
E
V
C
L
K
L
D
T
P
-
E
K
L
A
D
C
W
L
T
I
L
R
S
I
E
E
D
G
L
L
D
T
I
L
Y
V
---
D
L
-
C
N
E
-
W
P
G
-
D
S
W
A
P
F
F
A
K
T
Y
--
P
-
N
V
G
W
G
N
W
Y
K
E
E
S
L
R
W
M
K
T
S
L
E
K
M
-----
R
Q
V
Y
P
D
M
P
F
-
L
---
Y
S
F
D
H
G
D
V
K
K
Y
E
E
V
D
C
S
F
L
D
L
Y
E
--
H
H
I
W
M
A
Q
Q
N
G
G
E
F
Y
-
K
--
L
V
G
Y
G
Y
N
R
F
L
P
D
D
Y
K
N
V
V
K
N
A
E
R
V
Y
R
E
R
P
G
Y
W
Q
K
L
----------
L
T
D
K
I
E
L
M
A
S
V
-
A
R
K
N
R
R
P
L
V
T
T
E
C
W
G
L
V
D
Y
K
D
W
P
L
L
K
W
-----------------------------------------------
D
W
V
K
D
L
C
E
L
G
T
I
T
A
A
R
T
-
G
M
W
V
G
V
A
T
S
N
F
C
G
P
Q
F
A
G
M
W
---
R
D
V
E
W
H
K
R
L
T
S
I
-
I
-
R
S
S
P
L
D
E
S
L
-
T
------
K
N
N
E
V
A
A
K
L
L
K
R
L
-------------
26
HHSearch
39.07
8%
-13
- C2 -
3I9S
2
?
A:
[82-162]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
K
V
L
G
F
A
T
Y
T
I
M
F
PAPKL
S
G
-------
Q
M
Y
M
K
D
L
F
V
S
S
S
A
R
G
K
G
I
G
L
Q
L
M
K
H
L
A
T
I
A
I
T
H
-
N
-
C
Q
R
L
D
W
T
A
E
S
T
N
-----
P
---
T
A
G
K
F
Y
K
S
I
G
A
S
-
L
-
I
R
E
K
E
Y
Y
R
F
-
E
G
N
G
L
N
K
L
A
K
S
L
---------------------
1
PsiBlast_PDB
38.95
35%
-12
- C2 -
1XE4
1
FEMX_WEIVI
A:
[254-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
Y
A
G
S
-
M
D
G
N
T
Y
Y
A
P
Y
A
V
Q
S
E
M
I
Q
W
A
L
D
T
-
N
-
T
D
L
Y
D
L
G
G
I
E
S
E
-
S
T
D
-
D
---
S
L
Y
V
F
K
H
V
F
V
K
D
-
A
-
P
R
E
Y
I
G
E
I
D
-
K
V
L
D
P
E
V
Y
A
E
L
V
K
D
-------------------
3
PsiBlast_PDB
38.94
35%
-8
- C2 -
1P4N
4
FEMX_WEIVI
A:
[254-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
M
Y
A
G
S
-
M
D
G
N
T
Y
Y
A
P
Y
A
V
Q
S
E
M
I
Q
W
A
L
D
T
-
N
-
T
D
L
Y
D
L
G
G
I
E
S
E
-
S
T
D
-
D
---
S
L
Y
V
F
K
H
V
F
V
K
D
-
A
-
P
R
E
Y
I
G
E
I
D
-
K
V
L
D
P
E
V
Y
A
E
L
V
K
D
-------------------