@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1421: (2015-12-07 )
MLVYIAGSGAMGCRFGYQISKTNHDVILLDNWADHIMAIKENGLKVTGDTEDLVKLPIMKPTDATEEADLIILFTKAMQLPNMLQDIKKIIGKKTKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLKGPGHAHLEGVGSVNLQSIDPNNQEAGHRVTELLNEAKLQATYDENVLPNIWRKACVNGTMNSTCALLDCTIGQLFASEDGVNMVHEIIHEFVTVGKAEGVELDEEEITKYVMDTSVKAAHHYPSMHQDLVQNQRLTEIDFLNGAVNKKGENLGIDTPYCRLITQLIHTKENVLSIK
Atome Classification :
(20 SA)
.........10........20.------.......30........40.-....-...-50..-.---.-..-...--60.-.---...---.---..70........80........90........100..------------..-------------------.-------..110.......120.......130.......140........150........160.......170.......180.......190.....---..200........210.......220.......230-......-.240...--..-..250..-----.....260...-.....270.......280.......290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
V
Y
I
AGSGAMG
C
R
FG
Y
Q
ISKT------NH
D
V
I
L
LDNW
A
D
H
I
M
A
I
K
EN-
G
L
K
V-TGD-
T
-
E
D
-
L
---V-KL-PIM--KPT-D---ATE---E---A
D
L
I
I
L
F
T
K
A
M
QL
P
N
M
L
Q
D
I
K
K
I
IGKK
T
K
V
L
C
L
LNGL------------
G
H
-------------------
E
-------
D
V
I
R
Q
YIPEH
N
I
L
M
G
V
T
V
W
TAGLKGPGHA
H
L
EGV-GSV
N
L
Q
SIDP-N
N
Q
E
A
G
H
R
V
T
E
L
L
N
E
AK
L
Q
A
TYDEN
V
L
P
N
I
W
R
K
A
CVNGTMNS
T
C
A
L
---
L
D
C
T
-
I
G
Q
L
FASED
G
V
N
M
V
H
E
I
I
H
E
F
V
TVGKAEGVE-L
D
E
E
E
I
-
T
K
Y
V
M
DT--SV-
K
A
AHHY
P
-----
S
M
H
Q
D
L
V
-QNQ-RL
T
E
I
DFLNGAVNKKGENLGID
T
P
Y
C
R
L
I
T
Q
L
I
HTKENVLSIK
1
PsiBlast_PDB
97.49
45%
-116
- C3 -
3WFI
-
?
A:
[1-311]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
N
-
G
-
K
E
-
V
E
--
A
-
K
L
-
P
I
V
--
L
Q
S
-
E
---
V
E
K
---
E
DQ-
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
D
-
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
-
24
PsiBlast_CBE
95.52
45%
-118
- C3 -
3WFJ
1
?
D:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
-----------
A
-
K
L
-
P
I
V
--
L
Q
S
-
E
----------Q--
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
----
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
---
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
2
PsiBlast_PDB
95.13
45%
-121
- C3 -
3WFJ
1
?
A:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
-----
E
-
V
E--
A
-
K
L
-
P
I
V
--
L
Q
S
-
E
---
V
----------
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
--
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
D
-
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
26
PsiBlast_CBE
94.64
45%
-124
- C3 -
3WFJ
1
?
B:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
N
------
V
E--
A
-
K
L
-
P
I
V
--
L
Q
----------------
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
----
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
D
-
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
25
PsiBlast_CBE
94.59
45%
-124
- C3 -
3WFJ
1
?
C:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
-------
V
E--
A
-
K
L
-
P
I
V
--
L
Q
-------------Q--
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
--
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
---
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
23
PsiBlast_CBE
94.37
45%
-118
- C3 -
3WFJ
1
?
E:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
-------
V
E--
A
-
K
L
-
P
I
V
--
L
Q
S
---------------
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
D
-
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
21
PsiBlast_CBE
94.24
45%
-120
- C3 -
3WFJ
1
?
G:
[1-310]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
N
-
G
--------
A
-
K
L
-
P
I
V
--
L
Q
----------------
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
G
D
-
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
28
HHSearch
92.74
44%
-110
- C3 -
2EW2
2
?
A:
[4-316]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
L
G
I
M
L
H
Q
G
------
G
N
D
V
T
L
I
D
Q
W
P
A
H
I
E
A
I
R
K
N
-
G
L
I
A
-
D
F
N
-
G
-
E
E
-
V
V
--
A
-
N
L
-
P
I
F
S
P
E
E
I
D
H
---
Q
N
E
---
Q
---
V
D
L
I
I
A
L
T
K
A
Q
Q
L
D
A
M
F
K
A
I
Q
P
M
I
T
E
K
T
Y
V
L
C
L
L
N
G
L
------------
G
H
-------------------
E
-------
D
V
L
E
K
Y
V
P
K
E
N
I
L
V
G
I
T
M
W
T
A
G
L
E
G
P
G
R
V
K
L
L
G
D
-
G
E
I
-
E
L
E
N
I
D
P
S
G
K
K
F
A
L
E
V
V
D
V
F
Q
K
A
G
L
N
P
S
Y
S
S
N
V
R
Y
S
I
W
R
K
A
C
V
N
G
T
L
N
G
L
C
T
I
---
L
D
C
N
-
I
A
E
F
G
A
L
P
V
S
E
S
L
V
K
T
L
I
S
E
F
A
A
V
A
E
K
E
A
I
Y
-
L
D
Q
A
E
V
Y
T
H
I
V
Q
T
Y
--
D
P
N
G
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
K
N
H
R
-
L
-
T
E
I
D
Y
I
N
G
A
V
W
R
K
G
Q
K
Y
N
V
A
T
P
F
C
A
M
L
T
Q
L
V
H
G
K
E
E
L
L
G
A
K
27
HHSearch
91.51
43%
-111
- C3 -
3WFI
-
?
A:
[1-311]
M
K
I
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
Q
I
K
E
H
-
G
L
Q
A
-
N
F
N
-
G
-
K
E
-
V
E
A
K
L
-
P
I
-
V
L
Q
--
S
E
V
-
E
---
K
E
D
---
Q
---
V
D
L
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
I
K
K
D
T
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
-
E
L
Q
N
L
G
D
G
K
E
A
A
A
K
K
L
A
D
K
L
S
E
S
G
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
FD
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
K
N
H
R
-
L
-
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
V
-
22
PsiBlast_CBE
90.09
45%
-122
- C3 -
3WFJ
1
?
F:
[4-310]
---
A
I
A
G
A
G
A
M
G
S
R
F
G
L
M
L
H
Q
S
------
G
N
E
V
L
L
I
D
G
W
A
E
H
V
Q
---------------------------
L
-
P
I
V
--
L
--------------------
I
I
L
F
T
K
A
M
Q
L
E
K
M
L
Q
D
I
Q
S
L
-----
E
V
L
C
L
L
N
G
I
------------
G
H
-------------------
E
-------
D
I
I
E
K
F
V
P
M
E
N
I
Y
I
G
N
T
M
W
T
A
G
L
E
G
P
G
Q
V
K
L
F
G
S
-
G
S
V
E
L
Q
N
L
-----
E
A
A
A
K
K
L
A
D
K
L
----
L
N
A
H
F
S
D
N
I
H
Y
S
I
Y
R
K
A
C
V
N
G
T
M
N
G
L
C
T
I
---
L
D
V
N
-
M
A
E
L
G
K
T
S
T
A
H
K
M
V
A
T
I
V
N
E
F
A
K
V
A
A
V
E
K
I
E
-
L
D
V
P
E
V
-
I
A
H
C
E
S
C
F
D
P
E
-
T
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
I
S
R
K
G
K
K
Y
G
V
A
T
P
Y
C
D
F
L
T
E
L
V
H
A
K
E
D
S
L
N
--
3
PsiBlast_PDB
89.82
44%
-100
- C3 -
2EW2
2
?
A:
[17-316]
-------------
R
L
G
I
M
L
H
Q
G
------
G
N
D
V
T
L
I
D
Q
W
P
A
H
I
E
A
I
R
K
N
-
G
L
I
A
-
D
F
N
-
G
-
E
E
-
V
---
V
A
N
L
-
P
I
F
--
S
P
E
-
E
IDH
Q
N
E
---
Q
---
V
D
L
I
I
A
L
T
K
A
Q
Q
L
D
A
M
F
K
A
I
Q
P
M
I
T
E
K
T
Y
V
L
C
L
L
N
G
L
------------
G
H
-------------------
E
-------
D
V
L
E
K
Y
V
P
K
E
N
I
L
V
G
I
T
M
W
T
A
G
L
E
G
P
G
R
V
K
L
L
G
D
-
G
E
I
E
L
E
N
I
D
P
-
S
G
K
K
F
A
L
E
V
V
D
V
F
Q
K
A
G
L
N
P
S
Y
S
S
N
V
R
Y
S
I
W
R
K
A
C
V
N
G
T
L
N
G
L
C
T
I
---
L
D
C
N
-
I
A
E
F
G
A
L
P
V
S
E
S
L
V
K
T
L
I
S
E
F
A
A
V
A
E
K
E
A
I
Y
-
L
D
Q
A
E
V
-
Y
T
H
I
V
Q
T
Y
D
P
N
-
G
I
G
L
H
Y
P
-----
S
M
Y
Q
D
L
I
-
K
N
H
-
R
L
T
E
I
D
Y
I
N
G
A
V
W
R
K
G
Q
K
Y
N
V
A
T
P
F
C
A
M
L
T
Q
L
V
H
G
K
E
E
L
L
G
A
K
4
PsiBlast_PDB
77.19
27%
-99
- C3 -
3HWR
3
?
A:
[22-313]
--
V
A
I
M
G
A
G
A
V
G
C
Y
Y
G
G
M
L
A
R
A
------
G
H
E
V
I
L
I
A
R
-
P
Q
H
V
Q
A
I
E
A
T
-
G
L
R
L
E
T
Q
S
-
F
-
D
E
-
Q
---
V
-
K
V
-
S
A
S
--
S
D
P
-
S
---
A
V
Q
---
G
---
A
D
L
V
L
F
C
V
K
S
T
D
T
Q
S
A
A
L
A
M
K
P
A
L
A
K
S
A
L
V
L
S
L
Q
N
G
V
------------
E
N
-------------------
A
-------
D
T
L
R
S
L
L
E
Q
E
V
A
A
A
V
V
Y
V
A
T
E
-
M
A
G
P
G
H
V
R
H
H
G
R
-
G
E
L
---
V
I
E
P
-
T
S
H
--
G
A
N
L
A
A
I
F
A
A
A
G
V
P
V
E
T
S
D
N
V
R
G
A
L
W
A
K
L
I
L
N
C
A
Y
N
A
L
S
A
I
---
T
Q
L
P
-
Y
G
R
L
V
R
G
E
G
V
E
A
V
M
R
D
V
M
E
E
C
F
A
V
A
R
A
E
G
V
K
-
L
-
P
D
D
V
-
A
L
A
I
R
R
I
--
A
E
-
T
M
P
R
Q
S
S
-----
S
T
A
Q
D
L
A
-
R
G
K
-
R
-
S
E
I
D
H
L
N
G
L
I
V
R
R
G
D
A
L
G
I
P
V
P
A
N
R
V
L
H
A
L
V
R
L
I
E
D
K
Q
Q
H
G
34
HHSearch
76.95
27%
-96
- C3 -
3HWR
3
?
A:
[20-317]
M
K
V
A
I
M
G
A
G
A
V
G
C
Y
Y
G
G
M
L
A
R
A
------
G
H
E
V
I
L
I
A
R
P
-
Q
H
V
Q
A
I
E
A
T
-
G
L
R
L
-
E
T
Q
-
S
-
F
D
E
Q
---
V
-
K
V
-
S
A
S
--
S
D
P
-
S
---
A
V
Q
---
G
---
A
D
L
V
L
F
C
V
K
S
T
D
T
Q
S
A
A
L
A
M
K
P
A
L
A
K
S
A
L
V
L
S
L
Q
N
G
V
------------
E
N
-------------------
A
-------
D
T
L
R
S
L
L
E
-
Q
E
V
A
A
A
V
V
Y
V
A
T
E
M
A
G
P
G
H
V
R
H
H
G
R
-
G
E
L
-
V
I
E
P
T
S
-----
H
G
A
N
L
A
A
I
F
A
A
A
G
V
P
V
E
T
S
D
N
V
R
G
A
L
W
A
K
L
I
L
N
C
A
Y
N
A
L
S
A
I
---
T
Q
L
P
-
Y
G
R
L
V
R
G
E
G
V
E
A
V
M
R
D
V
M
E
E
C
F
A
V
A
R
A
E
G
V
K
-
L
P
D
D
V
--
A
L
A
I
R
R
I
--
A
E
-
T
M
P
R
Q
S
S
-----
S
T
A
Q
D
L
A
-
R
G
K
-
R
-
S
E
I
D
H
L
N
G
L
I
V
R
R
G
D
A
L
G
I
P
V
P
A
N
R
V
L
H
A
L
V
R
L
I
E
D
K
Q
Q
H
G
5
PsiBlast_PDB
76.73
24%
-105
- C3 -
3HN2
-
?
A:
[3-298]
--
I
A
I
V
G
A
G
A
L
G
L
Y
Y
G
A
L
L
Q
R
S
------
G
E
D
V
H
F
L
--
L
R
R
D
Y
E
A
I
A
G
N
-
G
L
K
V
-
F
S
I
-
N
-
G
D
-
F
---
T
--
L
-
P
H
V
--
K
G
Y
-
R
---
A
P
E
---
E
IGP
M
D
L
V
L
V
G
L
K
T
F
A
N
S
R
Y
E
E
L
I
R
P
L
V
E
E
G
T
Q
I
L
T
L
Q
N
G
L
------------
G
N
-------------------
E
-------
E
A
L
A
T
L
F
G
A
E
R
I
I
G
G
V
A
F
L
C
S
N
R
G
E
P
G
E
V
H
H
L
G
A
-
G
R
I
I
L
G
E
F
L
P
-
R
D
T
G
R
I
E
E
L
A
A
M
F
R
Q
A
G
V
D
C
R
T
T
D
D
L
K
R
A
R
W
E
K
L
V
W
N
I
P
F
N
G
L
C
A
L
---
L
Q
Q
P
-
V
N
L
I
L
A
R
D
V
S
R
K
L
V
R
G
I
M
L
E
V
I
A
G
A
N
A
Q
G
L
A
T
F
I
A
D
G
Y
-
V
D
D
M
L
E
F
--
T
D
-
A
M
G
E
Y
K
P
-----
S
M
E
I
D
R
E
-
E
G
R
-
P
L
-
E
I
A
A
I
F
R
T
P
L
A
Y
G
A
R
E
G
I
A
M
P
R
V
E
M
L
A
T
L
L
E
Q
A
T
G
E
----
32
HHSearch
74.65
23%
-101
- C3 -
3GHY
-
?
A:
[2-322]
T
R
I
C
I
V
G
A
G
A
V
G
G
Y
L
G
A
R
L
A
L
A
------
G
E
A
I
N
V
L
A
R
G
-
A
T
L
Q
A
L
Q
T
A
-
G
L
R
L
-
T
E
D
-
G
-
A
T
-
H
T
--
L
-
P
V
-
R
A
T
--
H
D
A
-
A
---
A
L
G
---
E
---
Q
D
V
V
I
V
A
V
K
A
P
A
L
E
S
V
A
A
G
I
A
P
L
I
G
P
G
T
C
V
V
V
A
M
N
G
V
------------
P
W
WFFDRPGPLQGQRLQAVDP
H
-------
G
R
I
A
Q
A
I
P
T
R
H
V
L
G
C
V
V
H
L
T
C
A
T
V
S
P
G
H
I
R
H
G
N
G
-
R
R
L
-
I
L
G
E
P
A
G
G
A
S
P
R
L
A
S
I
A
A
L
F
G
R
A
G
L
Q
A
E
C
S
E
A
I
Q
R
D
I
W
F
K
L
W
G
N
M
T
M
N
P
V
S
V
L
---
T
G
A
T
-
C
D
R
I
L
D
D
P
L
V
S
A
F
C
L
A
V
M
A
E
A
K
A
I
G
A
R
I
G
C
P
-
I
E
Q
S
G
E
---
A
R
S
A
V
--
T
R
-
Q
L
G
A
F
K
T
-----
S
M
L
Q
------
R
G
P
-
L
E
I
D
A
L
V
A
S
V
R
E
I
G
L
H
V
G
V
P
T
P
Q
I
D
T
L
L
G
L
V
R
L
H
A
Q
T
R
G
L
Y
12
PsiBlast_PDB
72.69
24%
-97
- C3 -
3GHY
-
?
A:
[4-306]
--
I
C
I
V
G
A
G
A
V
G
G
Y
L
G
A
R
L
A
L
A
------
G
E
A
I
N
V
L
A
R
G
A
T
-
L
Q
A
L
Q
T
A
-
G
L
R
L
-
T
E
D
-
G
-
A
T
-
H
---
T
--
L
-
P
V
R
--
A
T
H
-
D
---
A
A
A
LG-
E
---
Q
D
V
V
I
V
A
V
K
A
P
A
L
E
S
V
A
A
G
I
A
P
L
I
G
P
G
T
C
V
V
V
A
M
N
G
V
PWWFFDRPGPLQ
G
Q
-------------------
R
LQAVDPH
G
R
I
A
Q
A
I
P
T
R
H
V
L
G
C
V
V
H
L
T
C
A
T
V
S
P
G
H
I
R
H
G
N
G
-
R
R
L
I
L
G
E
P
A
G
-
G
A
S
P
R
L
A
S
I
A
A
L
F
G
R
A
G
L
Q
A
E
C
S
E
A
I
Q
R
D
I
W
F
K
L
W
G
N
M
T
M
N
P
V
S
V
L
---
T
G
A
T
-
C
D
R
I
L
D
D
P
L
V
S
A
F
C
L
A
V
M
A
E
A
K
A
I
G
A
R
I
G
C
P
-
I
E
Q
S
G
E
-
A
R
S
A
V
T
R
--
Q
L
-
G
A
--
F
K
T
-----
S
M
L
Q
------
R
-
G
P
L
E
I
D
A
L
V
A
S
V
R
E
I
G
L
H
V
G
V
P
T
P
Q
I
D
T
L
L
G
L
V
R
L
H
A
Q
T
R
G
L
Y
29
HHSearch
71.97
21%
-102
- C3 -
2QYT
10
?
A:
[9-313]
I
K
I
A
V
F
G
L
G
G
V
G
G
Y
Y
G
A
M
L
A
L
R
A
A
A
T
DG
L
L
E
V
S
W
I
A
R
-
G
A
H
L
E
A
I
R
A
A
G
G
L
R
V
-
V
T
P
-
S
-
R
D
-
F
L
--
A
-
R
P
T
C
V
T
--
D
N
P
-
A
---
E
V
G
---
T
---
V
D
Y
I
L
F
C
T
K
D
Y
D
M
E
R
G
V
A
E
I
R
P
M
I
G
Q
N
T
K
I
L
P
L
L
N
G
A
------------
D
I
-------------------
A
-------
E
R
M
R
T
Y
L
P
D
T
V
V
W
K
G
C
V
Y
I
S
A
R
K
S
A
P
G
L
I
T
L
E
A
D
R
E
L
F
-
Y
F
G
S
G
L
P
E
Q
T
D
D
E
V
R
L
A
E
L
L
T
A
A
G
I
R
A
Y
N
P
T
D
I
D
W
Y
I
M
K
K
F
M
M
I
S
V
T
A
T
A
T
A
Y
---
F
D
K
P
-
I
G
S
I
L
T
E
H
--
E
P
E
L
L
S
L
L
E
E
V
A
E
L
F
R
A
K
Y
G
Q
-
V
P
D
D
V
V
-
Q
Q
L
L
D
K
Q
--
R
K
-
M
----------------------------
E
T
L
T
G
Y
V
V
R
E
A
E
A
L
R
V
D
L
P
M
Y
K
R
M
Y
R
E
L
V
S
--------
31
HHSearch
71.53
19%
-99
- C3 -
3I83
1
?
A:
[3-308]
L
N
I
L
V
I
G
T
G
A
I
G
S
F
Y
G
A
L
L
A
K
T
------
G
H
C
V
S
V
V
S
R
S
--
D
Y
E
T
V
K
A
K
-
G
I
R
I
-
R
S
A
T
L
-
G
D
-
Y
T
--
F
-
R
P
A
A
V
V
--
R
S
A
-
A
E--
L
E
T
---
K
---
P
D
C
T
L
L
C
I
K
V
V
E
G
A
D
R
V
G
L
L
R
D
A
V
A
P
D
T
G
I
V
L
I
S
N
G
I
------------
D
I
-------------------
E
-------
P
E
V
A
A
A
F
P
D
N
E
V
I
S
G
L
A
F
I
G
V
T
R
T
A
P
G
E
I
W
H
Q
A
Y
-
G
R
L
-
M
L
G
N
Y
P
G
G
V
S
E
R
V
K
T
L
A
A
A
F
E
E
A
G
I
D
G
I
A
T
E
N
I
T
T
A
R
W
Q
K
C
V
W
N
A
A
F
N
P
L
S
V
L
---
S
G
G
L
D
T
L
D
I
L
S
T
Q
--
E
G
F
V
R
A
I
M
Q
E
I
R
A
V
A
A
A
N
G
H
P
-
L
P
E
D
I
V
-
E
K
N
V
A
S
---
T
Y
-
K
M
P
P
Y
K
T
-----
S
M
L
V
D
F
E
-
A
G
Q
-
P
-
M
E
T
E
V
I
L
G
N
A
V
R
A
G
R
R
T
R
V
A
I
P
H
L
E
S
V
Y
A
L
M
K
L
L
E
L
R
T
S
K
S
14
PsiBlast_PDB
69.33
21%
-86
- C3 -
3I83
1
?
A:
[5-302]
--
I
L
V
I
G
T
G
A
I
G
S
F
Y
G
A
L
L
A
K
T
------
G
H
C
V
S
V
V
S
R
-
S
D
Y
-
E
T
V
K
A
K
-
G
I
R
I
-
R
S
A
-
T
L
G
D
-
Y
---
T
-
F
R
-
P
A
A
--
V
V
R
-
S
---
A
A
E
LET
K
---
P
D
C
T
L
L
C
I
K
V
V
E
G
A
D
R
V
G
L
L
R
D
A
V
A
P
D
T
G
I
V
L
I
S
N
G
I
------------
D
I
-------------------
E
-------
P
E
V
A
A
A
F
P
D
N
E
V
I
S
G
L
A
F
I
G
V
T
R
T
A
P
G
E
I
W
H
Q
A
Y
-
G
R
L
M
L
G
N
Y
P
G
-
G
V
S
E
R
V
K
T
L
A
A
A
F
E
E
A
G
I
D
G
I
A
T
E
N
I
T
T
A
R
W
Q
K
C
V
W
N
A
A
F
N
P
L
S
V
L
S
GG
L
D
T
L
---
D
I
L
S
T
Q
E
G
--
F
V
R
A
I
M
Q
E
I
R
A
V
A
A
A
N
G
H
P
-
L
P
E
D
I
V
-
E
K
N
V
A
S
T
---
Y
-
K
M
P
P
Y
K
T
-----
S
M
L
V
D
F
E
-
A
G
Q
-
P
M
-
E
T
E
V
I
L
G
N
A
V
R
A
G
R
R
T
R
V
A
I
P
H
L
E
S
V
Y
A
L
M
K
L
L
E
L
R
T
S
K
S
10
PsiBlast_PDB
69.19
21%
-100
- C3 -
3G17
-
?
A:
[5-285]
--
V
A
I
I
G
P
G
A
V
G
T
T
I
A
Y
E
L
Q
Q
S
------
L
P
H
T
T
L
I
G
R
H
A
K
T
I
T
Y
Y
T
V
P
-
H
-----
A
P
-
A
-
Q
D
-
I
---
V
-----
V
K
--
G
Y
E
-
D
---
V
T
N
---
T
---
F
D
V
I
I
I
A
V
K
T
H
Q
L
D
A
V
I
P
H
L
T
Y
L
A
H
E
D
T
L
I
I
L
A
Q
N
G
Y
------------
G
Q
------------------------------
L
E
H
I
P
F
K
N
V
C
Q
A
V
V
Y
I
S
G
Q
K
K
G
D
V
V
T
H
F
R
D
Y
-------
Q
L
R
I
-
Q
D
N
A
L
T
R
Q
F
R
D
L
V
Q
D
S
Q
I
D
I
V
L
E
A
N
I
Q
Q
A
I
W
Y
K
L
L
V
N
L
G
I
N
S
I
T
A
L
---
G
R
Q
T
-
V
A
I
M
H
N
P
E
I
R
I
-
L
C
R
Q
L
L
L
D
G
C
R
V
A
Q
A
E
G
L
N
-
F
S
E
Q
T
V
------
D
T
--
I
M
-
T
I
Y
Q
G
Y
P
DEMGT
S
M
Y
Y
D
I
V
-
H
Q
Q
-
P
L
-
E
V
E
A
I
Q
G
F
I
Y
R
R
A
R
E
H
N
L
D
T
P
Y
L
D
T
I
Y
S
F
L
R
A
Y
Q
Q
N
E
G
--