@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1435: (2015-12-07 )
MEITIKIAGVRLDKALADNSELSRSQANEEIKKGIVLVNGQVKKAKYTVQEGDRITFDIPKEEVLDYQAENISLDIIYQDDDVAVVNKPQGMVVHPSAGHSSGTLVNALMYHIKDLSSINGVVRPGIVHRIDKDTSGLLMVAKNDRAHQVLAEELKDKKSLRKYLAIVHGNLPNDRGVIEAPIGRSDKDRKKQAVTAKGKPAITRFHVLERFGDYTLVELSLETGRTHQIRVHMAYIGHPLAGDSVYGPRKTLEGKGQFLHAQTLGFTHPSNGENLIFSVEVPEIFQTTLDKLRKN
Atome Classification :
(20 SA)
-------.........10........-.-20........30........40-.-..-.....50........60........70........80....-....90........100....--....110.......120.......130......-.140.....-...150.......160.......170........180....--.-..190..-...-.---..-.200-----...-----..---..-210......-..220.......230.-......240......--.------------250----.-------------...-..---.---.-----------260..-.....270...-....280.--..-....---290....----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------
M
E
I
T
I
K
I
A
G
V
-
R
L
D
K
ALAD-
N
-
S
E
L
S
R
S
Q
A
N
E
E
I
KK
G
I
V
L
VNG
Q
-
V
-
K
K
-
A
K
Y
T
VQEG
D
R
I
T
F
DI
P
K
E
E
V
L
DYQAEN
I
S
L
D
I
I
Y
QDD
D
V
A
V
-
V
NKPQ
G
M
V
VHPSAGH-SS
G
T
L
--
V
N
A
L
M
Y
H
I
K
D
L
S
SINGVVRP
G
I
V
H
RIDKDTS
G
L
-
L
M
-
V
AKND
R
-
A
H
Q
V
L
A
E
E
L
K
D
K
K
S
L
R
K
Y
L
A
I
V
HGN-LPNDRG
V
I
EAPIGRS--
D
-
K
D
R
--
K
K-QAV-T---AK-GK
P
A
-----
I
T
R
-----
F
H
---
V
L
-
E
R
-FG
D
Y
T
L
-
V
E
L
S
LETG
R
T
H
Q
I
R
V
H
-
M
A
YIGHPLAGDSVYG--P------------RK-----T-------------LEG-KG---
Q
---
F
-----------
L
H
A
Q
T-LGFTHPSNG
E
N
-
L
I
F
S
V
E
V
P
--
E
I
-
F
Q
T
T
---
L
D
K
LRKN----------
34
Fugue
98.11
40%
-86
- C4 -
2IST
3
RLUD_ECOLI
A:
[1-324]
A
Q
R
V
Q
L
T
A
T
V
S
E
N
Q
L
G
Q
-
R
L
D
Q
A
L
A
E
M
F
-
P
D
Y
S
R
S
R
I
K
E
W
I
L
D
Q
R
V
L
V
N
G
K
V
C
-
D
K
-
P
K
E
K
V
L
G
G
E
Q
V
A
I
N
A
E
I
E
R
---
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
---
Y
P
P
I
A
D
V
P
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
-
M
V
-
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
-
M
T
A
G
-
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
-
M
A
V
-
H
---
P
M
-
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
M
-
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
G
--
G
------------
R
P
-----
R
P
P
K
GAS
E
A
F
I
S
T
L
R
K
F
-
D
R
---
Q
---
A
-----------
L
H
A
T
M
-
L
R
L
Y
H
P
I
S
G
I
E
-
M
E
W
H
A
P
I
P
--
Q
D
-
M
V
E
L
---
I
E
V
M
R
A
D
F
E
E
H
KDEVDW
2
PsiBlast_PDB
96.37
39%
-87
- C4 -
2IST
3
RLUD_ECOLI
A:
[16-314]
---------------
G
Q
-
R
L
D
Q
A
L
A
E
-
M
F
P
D
Y
S
R
S
R
I
K
E
W
I
L
D
Q
R
V
L
V
N
G
K
-
V
C
D
K
-
P
K
E
K
V
L
G
G
E
Q
V
A
I
N
A
E
I
E
---
R
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
---
Y
P
P
I
A
D
V
P
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
-
M
V
-
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
-
M
-
T
A
G
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
-
M
A
V
-
H
---
P
M
-
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
M
-
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
G
GR
P
------------
R
P
-----
P
-------------
K
G
A
-
S
E
---
A
---
F
I
S
T
L
R
K
FDRQA
L
H
A
T
M
-
L
R
L
Y
H
P
I
S
G
I
E
-
M
E
W
H
A
P
I
P
--
Q
D
-
M
V
E
L
---
I
E
V
M
R
A
D
----------
14
HHSearch
88.16
41%
-90
- C4 -
1V9F
1
RLUD_ECOLI
A:
[76-313]
-------------------------------------------------------------------------------
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
Y
P
P
I
---
A
D
V
P
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
-
M
V
-
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
-
M
T
A
-
G
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
-
M
A
V
-
H
---
P
M
-
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
M
-
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
G
--
G
------------
R
P
-----
R
PPKGAS
E
A
F
I
S
T
L
R
K
F
-
D
R
---
Q
---
A
-----------
L
H
A
T
M
-
L
R
L
Y
H
P
I
S
G
I
E
-
M
E
W
H
A
P
I
P
--
Q
D
-
M
V
E
L
---
I
E
V
M
R
A
D
----------
1
PsiBlast_PDB
86.34
39%
-92
- C4 -
1V9F
1
RLUD_ECOLI
A:
[76-314]
-------------------------------------------------------------------------------
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
---
Y
P
P
I
A
D
V
P
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
-
M
V
-
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
-
M
-
T
A
G
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
-
M
A
V
-
H
---
P
M
-
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
M
-
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
G
GR
P
------------
R
P
-----
P
-------------
K
G
A
-
S
E
---
A
---
F
I
S
T
L
R
K
FDRQA
L
H
A
T
M
-
L
R
L
Y
H
P
I
S
G
I
E
-
M
E
W
H
A
P
I
P
--
Q
D
-
M
V
E
L
---
I
E
V
M
R
A
D
----------
5
PsiBlast_PDB
81.78
40%
-86
- C4 -
1XPI
3
RLUC_ECOLI
A:
[7-228]
----------------------------------------------------------------------------------------
I
L
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
G
G
S
G
L
-
S
F
G
V
I
E
G
L
R
A
L
R
--
A
R
F
L
E
---------
L
V
H
R
L
D
R
D
T
S
G
V
-
L
L
-
V
A
K
K
R
S
-
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
-
W
Q
S
H
V
K
S
V
Q
A
P
L
L
K
N
I
L
Q
-
S
G
E
--
R
I
-
V
R
V
-
S
---
Q
E
-
G
K
P
S
-----
E
T
R
-----
F
K
---
V
E
-
E
R
-
Y
A
F
A
T
L
-
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
G
--
D
------------
R
E
F
D
R
Q
L
T
-------------
E
A
G
-
T
G
LNR
L
---
F
-----------
L
H
A
A
A
-
L
K
F
T
H
P
G
T
G
E
V
-
M
R
I
E
A
P
M
D
--
E
G
-
L
K
R
C
---
L
Q
K
L
R
N
A
----------
15
HHSearch
81.74
40%
-82
- C4 -
1V9K
1
RLUC_ECOLI
A:
[3-227]
---------------------------------------------------------------------------------------
V
I
M
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
G
G
S
G
L
--
S
F
G
V
--
I
E
G
L
R
A
L
R
P
------
E
A
R
F
L
E
L
V
H
R
L
D
R
D
T
S
G
V
-
L
L
-
V
A
K
K
R
S
-
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
-
W
Q
S
H
V
K
S
V
Q
A
P
L
L
K
N
--
I
-
L
Q
S
G
E
R
I
-
V
R
V
-
S
---
Q
E
-
G
K
P
S
-----
E
T
R
-----
F
K
---
V
E
-
E
R
-
Y
A
F
A
T
L
-
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
G
--
D
------------
R
E
-----
F
D
R
Q
L
T
E
A
G-----
T
G
L
-
N
R
---
L
---
F
-----------
L
H
A
A
A
-
L
K
F
T
H
P
G
T
G
E
V
-
M
R
I
E
A
P
M
D
--
E
G
-
L
K
R
C
---
L
Q
K
M
R
N
A
----------
6
PsiBlast_PDB
80.69
40%
-81
- C4 -
1V9K
1
RLUC_ECOLI
A:
[4-225]
----------------------------------------------------------------------------------------
I
M
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
G
G
S
G
L
-
S
F
G
V
I
E
G
L
R
A
L
R
P
E
A
R
F
L
E
---------
L
V
H
R
L
D
R
D
T
S
G
V
-
L
L
-
V
A
K
K
R
S
-
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
-
W
Q
S
H
V
K
S
V
Q
A
P
L
L
K
N
I
L
Q
-
S
G
E
--
R
I
-
V
R
V
-
S
---
Q
E
-
G
K
P
S
-----
E
T
R
-----
F
K
---
V
E
-
E
R
-
Y
A
F
A
T
L
-
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
G
--
D
------------
R
E
F
D
R
Q
L
T
-------------
E
A
G
-
T
G
---
L
NRL
F
-----------
L
H
A
A
A
-
L
K
F
T
H
P
G
T
G
E
---
V
M
R
I
E
A
P
M
D
E
G
-
L
K
R
C
---
L
Q
K
M
R
N
A
----------
13
PsiBlast_CBE
80.50
40%
-84
- C4 -
1XPI
2
RLUC_ECOLI
B:
[7-228]
----------------------------------------------------------------------------------------
I
L
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
G
G
S
G
L
-
S
F
G
V
I
E
G
L
R
A
L
R
P
E
A
R
F
L
E
---------
L
V
H
R
L
D
R
D
T
S
G
V
-
L
L
-
V
A
K
K
R
S
-
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
-
W
Q
S
H
V
K
S
V
Q
A
P
L
L
K
N
I
L
Q
-
S
G
E
--
R
I
-
V
R
V
-
S
---
Q
E
-
G
K
P
S
-----
E
T
R
-----
F
K
---
V
E
-
E
R
-
Y
A
F
A
T
L
-
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
G
--
D
------------
R
E
F
D
R
Q
L
T
-------------
E
A
G
-
T
G
LNR
L
---
F
-----------
L
H
A
A
A
-
L
K
F
T
H
P
G
T
G
E
V
-
M
R
I
E
A
P
M
D
--
E
G
-
L
K
R
C
---
L
Q
K
L
R
N
-----------
16
HHSearch
73.31
33%
-82
- C4 -
2I82
2
RLUA_ECOLI
A:
[9-217]
-----------------------------------------------------------------------------------
E
P
W
L
V
I
L
Y
Q
D
D
H
I
M
V
-
V
N
K
P
S
G
L
L
S
V
P
G
R
L
E
E
H
K
D
S
V
--
M
T
R
I
Q
R
D
---------
Y
P
Q
A
E
S
V
H
R
L
D
M
A
T
S
G
V
-
I
V
-
V
A
L
T
K
A
-
A
E
R
E
L
K
R
Q
F
R
E
R
E
P
K
K
Q
Y
V
A
R
V
W
G
H
-
P
S
P
A
E
G
L
V
D
L
P
L
I
C
D
--
W
-
P
N
R
--
P
K
-
Q
K
V
C
Y
---
E
T
-
G
K
P
A
-----
Q
T
E
-----
Y
E
---
V
V
-
E
Y
A
A
D
N
T
A
R
-
V
V
L
K
P
I
T
G
R
S
H
Q
L
R
V
H
-
M
L
A
L
G
H
P
I
L
G
D
R
F
Y
A
--
S
------------
P
E
-----
A
R
------------
A
M
A
-
P
R
---
L
---
L
-----------
L
H
A
E
M
-
L
T
I
T
H
P
A
Y
G
N
S
-
M
T
F
K
A
P
A
D
--
F
--------------------------
7
PsiBlast_PDB
72.57
34%
-77
- C4 -
2I82
2
RLUA_ECOLI
A:
[12-211]
--------------------------------------------------------------------------------------
L
V
I
L
Y
Q
D
D
H
I
M
V
-
V
N
K
P
S
G
L
L
S
V
P
G
R
L
E
-
E
H
K
D
S
--
V
M
T
R
I
Q
--
R
D
Y
P
Q
A
E
S
V
------
H
R
L
D
M
A
T
S
G
V
-
I
V
-
V
A
L
T
K
A
-
A
E
R
E
L
K
R
Q
F
R
E
R
E
P
K
K
Q
Y
V
A
R
V
W
G
H
-
P
S
P
A
E
G
L
V
D
L
P
L
I
C
D
--
W
-
P
N
R
--
P
K
-
Q
K
V
-
C
---
Y
E
T
G
K
P
A
-----
Q
T
E
-----
Y
E
---
V
V
-
E
Y
-
A
A
D
N
T
A
R
V
V
L
K
P
I
T
G
R
S
H
Q
L
R
V
H
-
M
L
A
L
G
H
P
I
L
G
D
R
F
Y
A
S-
P
------------
E
A
-----
R
-------------
A
M
A
-
P
R
---
L
---
L
-----------
L
H
A
E
M
-
L
T
I
T
H
P
A
Y
G
N
S
-
M
T
F
K
A
P
A
D
--
F
--------------------------
35
Fugue
57.32
41%
-11
- C4 -
1PRZ
-
RLUD_ECOLI
A:
[75-326]
-----------------------------------------------------------------------------
A
R
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
V
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
Y
P
P
I
A
D
V
P
---
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
M
V
--
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
G
--
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
M
A
---
V
---
H
P
M
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
-M
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
M
A
-
H
I
T
H
P
L
V
G
D
P
V
Y
G
--
G
R
P
R
P
P
KGAS
E
A
F
I
S
-----
T
-------------
L
R
K
F
D
R
---
Q
---
A
-----------
L
H
A
-
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
-
W
H
A
P
I
P
--
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
E
E
H
KDEVDWL---
4
PsiBlast_PDB
56.42
41%
-20
- C4 -
1PRZ
-
RLUD_ECOLI
A:
[77-303]
-------------------------------------------------------------------------------
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
V
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
---
Y
P
P
I
A
D
V
P
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
-
M
V
-
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
-
M
-
T
A
G
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
-
M
A
V
-
H
---
P
M
-
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
M
-
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
G
G
R
P
------------
R
P
-----
P
-------------
K
G
A
-
S
E
---
A
---
F
I
S
T
L
R
K
FDRQA
L
H
A
T
M
-
L
R
L
Y
H
P
I
S
G
I
E
-
M
E
W
H
A
P
I
P
--
Q
D
-
M
V
E
L
---
I
E
V
M
R
A
D
----------
18
HHSearch
55.71
21%
-63
- C4 -
1KSK
1
RSUA_ECOLI
A:
[2-210]
--------------
S
H
M
-
R
L
D
K
F
I
A
Q
-
Q
-
L
G
V
S
R
A
I
A
G
R
E
I
R
G
N
R
V
T
V
D
G
E
-
I
-
V
R
N
A
A
F
K
L
L
P
E
H
D
V
A
Y
D
G
N
P
-----
L
-------
A
-
Q
Q
H
G
P
R
Y
F
M
-
L
N
K
P
Q
G
Y
V
C
S
T
D
D
P
D
--
H
P
T
V
--
L
Y
F
L
D
E
P
--------
V
A
W
K
L
H
A
A
G
R
L
D
I
D
T
T
G
L
-
V
L
-
M
T
D
D
G
Q
-
W
S
H
R
I
T
S
P
--
R
H
H
C
E
K
T
Y
L
V
T
L
E
S
P
-
V
A
D
--
D
T
A
E
Q
F
A
K
--------
G
-----
V
Q
L
-
H
NEK
D
L
-
T
K
P
A
-----
V
L
E
-----
V
I
-----------
T
P
T
Q
-
V
R
L
T
I
S
E
G
R
Y
H
Q
V
K
R
M
-
F
A
A
V
G
N
H
V
V
E
L
H
R
E
R
--
I
------------
G
G
-----
I
-------------
T
L
D
-
A
D
---
L
---
A
-----------
P
G
E
Y
R
-
P
L
T
E
E
E
I
A
S
V
V
--------------------------------------
8
PsiBlast_PDB
54.23
25%
-44
- C4 -
1VIO
4
RSUA_HAEIN
A:
[3-201]
----------------
L
-
R
L
D
K
F
I
A
E
-
N
-
V
G
L
T
R
S
Q
A
T
K
A
I
R
Q
S
A
V
K
I
N
G
E
I
V
-
K
S
-
G
S
V
Q
I
S
Q
E
D
E
I
Y
F
E
---
D
E
L
L
T
W
I
E
E
G
----------
Q
Y
F
M
-
L
N
K
P
Q
G
C
V
C
S
N
D
D
---
Y
--------
P
T
I
Y
Q
F
F
D
Y
P
L
A
G
K
L
H
S
A
G
---
R
L
D
V
D
T
T
G
L
-
V
L
-
L
T
D
D
G
Q
W
S
H
R
I
T
S
P
K
H
H
C
E
K
T
Y
L
V
T
L
A
---------------
D
P
V
E
E
N
--
Y
-
S
A
A
--
C
A
-
E
G
I
-
L
---
L
R
-
G
E
K
E
-----
P
T
K
-----
P
A
---
K
L
-
E
I
-
L
D
D
Y
N
--
V
N
L
T
I
S
E
G
R
Y
H
Q
V
K
R
M
-
F
A
A
L
G
N
K
V
V
G
L
H
R
W
K
--
I
------------
G
D
-----
V
-------------
V
L
D
-
E
S
---
L
---
E
-----------
E
G
E
Y
R
-
P
L
T
Q
S
E
I
E
K
L
V
--------------------------------------
3
PsiBlast_PDB
53.72
40%
-25
- C4 -
1QYU
-
RLUD_ECOLI
A:
[77-303]
-------------------------------------------------------------------------------
F
E
P
Q
D
I
P
L
D
I
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
P
G
A
G
N
-
P
D
G
T
V
--
L
N
A
L
L
H
Y
---
Y
P
P
I
A
D
V
P
R
A
G
I
V
H
R
L
D
K
D
T
T
G
L
-
M
V
-
V
A
K
T
V
P
-
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
-
M
-
T
A
G
G
T
V
D
E
P
I
S
R
H
--
P
-
T
K
R
--
T
H
-
M
A
V
-
H
---
P
M
-
G
K
P
A
-----
V
T
H
-----
Y
R
---
I
M
-
E
H
-
F
R
V
H
T
R
-
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
G
GR
P
------------
R
P
-----
P
-------------
K
G
A
-
S
E
---
A
---
F
I
S
T
L
R
K
FDRQA
L
H
A
T
M
-
L
R
L
Y
H
P
I
S
G
I
E
-
M
E
W
H
A
P
I
P
--
Q
D
-
M
V
E
L
---
I
E
V
M
R
A
D
----------
37
Fugue
52.46
21%
-41
- C4 -
1KSK
1
RSUA_ECOLI
A:
[1-234]
--------------
G
S
H
M
R
L
D
K
F
I
A
Q
-
Q
-
L
G
V
S
R
A
I
A
G
R
E
I
R
G
N
R
V
T
V
D
G
E
-
I
-
V
R
N
A
A
F
K
L
L
P
E
H
D
V
A
Y
D
--------------
G
N
P
L
A
Q
Q
H
G
P
R
Y
F
M
L
N
K
P
Q
G
Y
V
C
S
T
D
D
P
D
-
H
P
T
-----------
V
L
Y
F
L
D
E
P
V
A
W
K
L
H
A
A
G
R
L
D
I
D
T
T
G
L
-
V
L
M
T
D
D
G
Q
W
-
S
H
R
I
T
S
P
R
H
H
C
E
---
K
T
Y
L
V
T
L
E
S
P
-
V
A
D
D
-------------
T
-
A
E
Q
--
F
A
-
K
G
V
-
Q
---
L
H
-
N
E
K
D
-----
L
T
K
-----
P
A
---
V
L
-
E
V
-
I
T
P
-
T
Q
-
V
R
L
T
I
S
E
G
R
Y
H
Q
V
K
-
R
M
F
A
A
V
G
N
H
------------------------------
V
-------------
V
E
L
-
H
R
---
E
---
R
-----------
I
G
G
I
T
-
L
D
A
D
L
A
P
G
E
Y
R
-
P
L
T
E
E
E
I
A
--
S
V
-
V
-----------------------
17
HHSearch
51.16
25%
-53
- C4 -
1VIO
4
RSUA_HAEIN
A:
[2-209]
---------------
S
L
-
R
L
D
K
F
I
A
E
-
N
-
V
G
L
T
R
S
Q
A
T
K
A
I
R
Q
S
A
V
K
I
N
G
E
-
I
-
V
K
S
G
S
V
Q
I
S
Q
E
D
E
I
Y
F
E
D
-------------
E
L
L
T
W
I
E
E
G
Q
Y
F
M
-
L
N
K
P
Q
G
C
V
C
S
N
D
D
----
Y
P
T
I
--
Y
Q
F
F
D
Y
P
L
--------
A
G
K
L
H
S
A
G
R
L
D
V
D
T
T
G
L
-
V
L
-
L
T
D
D
G
Q
-
W
S
H
R
I
T
S
P
--
K
H
H
C
E
K
T
Y
L
V
T
L
A
D
P
-
V
E
E
N
Y
S
---
A
A
C
A
E
G
--
I
-
L
-----
L
-
R
G
E
-
K
---
E
P
-
T
K
P
A
-------
K
-----
L
E
---
I
L
-
D
-----
D
Y
N
-
V
N
L
T
I
S
E
G
R
Y
H
Q
V
K
R
M
-
F
A
A
L
G
N
K
V
V
G
L
H
R
W
K
--
I
------------
G
D
-----
V
-------------
V
L
D
-
E
S
---
L
---
E
-----------
E
G
E
Y
R
-
P
L
T
Q
S
E
I
E
K
L
V
--------------------------------------
19
HHSearch
50.70
20%
-54
* C4 *
3DH3
1
RLUF_ECOLI
A:
[4-207]
-------------
D
S
S
V
-
R
L
N
K
Y
I
S
E
-
S
-
G
I
C
S
R
R
E
A
D
R
Y
I
E
Q
G
N
V
F
L
N
G
K
-
R
-
A
T
-
I
G
D
Q
V
K
P
G
D
V
V
K
V
N
G
Q
L
-----
I
E
------
P
R
E
A
E
D
L
V
L
I
A
-
L
N
K
P
V
G
I
V
S
T
T
E
D
G
E
--
R
D
N
I
--
V
D
F
V
N
H
----------
S
K
R
V
F
P
I
G
R
L
D
K
D
S
Q
G
L
-
I
F
-
L
T
N
H
G
D
-
L
V
N
K
I
L
R
A
G
--
N
D
H
E
K
E
Y
L
V
T
V
D
K
P
-
I
T
E
E
F
--
I
R
G
-
M
S
-------
A
G
--
V
P
---
I
------
L
---
G
T
-----
V
T
K
-----
K
C
---
K
V
-
K
--
K
E
A
P
F
V
-
F
R
I
T
L
V
Q
G
L
N
R
Q
I
R
R
M
-
C
E
H
F
G
Y
E
V
K
K
L
E
R
T
R
--
I
------------
M
N
-----
V
-------------
S
L
S
-
G
I
---
P
---
L
-----------
G
E
W
R
D
-
L
T
D
D
E
L
I
D
L
F
K
-
L
I
E
N
S
S
S
E
--
V
--------------------------
20
HHSearch
45.31
22%
-53
- C4 -
2OML
5
RLUE_ECOLI
A:
[8-173]
------------------------------------------------------------------------------------------
N
Q
P
T
R
V
I
L
-
F
N
K
P
Y
D
V
L
P
Q
F
T
D
E
A
-
G
R
K
T
L
--
K
E
F
I
P
-----------
V
Q
G
V
Y
A
A
G
R
L
D
R
D
S
E
G
L
-
L
V
-
L
T
N
N
G
A
-
L
Q
A
R
L
T
Q
P
G
K
--
R
T
G
K
I
Y
Y
V
Q
V
E
G
I
-
P
T
Q
D
--
A
L
E
A
-
L
R
N
G
--
V
T
L
N
D
--
G
---
P
T
-
L
---
P
A
-
G
A
E
L
-----
V
D
E
PAW
L
W
P
R
NPP
I
R
--
R
K
S
I
P
T
S
W
-
L
K
I
T
L
Y
E
G
R
N
R
Q
V
R
R
M
-
T
A
H
V
G
F
P
T
L
R
L
I
R
Y
A
--
M
------------
G
D
-----
Y
-------------
S
L
D
-
N
L
---
A
---
N
-----------
G
E
W
R
E
-
V
T
D
----------------------------------------------
21
HHSearch
45.09
20%
-55
- C4 -
2OLW
4
RLUE_ECOLI
A:
[37-201]
-------------------------------------------------------------------------------------------
Q
P
T
R
V
I
L
-
F
N
K
P
Y
D
V
L
P
Q
F
T
D
E
A
-
G
R
K
T
L
--
K
E
F
I
P
-----------
V
Q
G
V
Y
A
A
G
R
L
D
R
D
S
E
G
L
-
L
V
-
L
T
N
N
G
A
-
L
Q
A
R
L
T
Q
P
G
--
K
R
T
G
K
I
Y
Y
V
Q
V
E
G
I
-
P
T
Q
D
--
A
L
E
A
-
L
R
N
G
V
-
T
-
L
N
D
--
G
P
---
T
-
L
---
P
A
-
G
A
E
L
V
D
EPA
W
L
W
-----
P
R
NPP
I
R
--
R
K
S
I
P
T
S
W
-
L
K
I
T
L
Y
E
G
R
N
R
Q
V
R
R
M
-
T
A
H
V
G
F
P
T
L
R
L
I
R
Y
A
--
M
------------
G
D
-----
Y
-------------
S
L
D
-
N
L
---
A
---
N
-----------
G
E
W
R
E
-
V
T
-----------------------------------------------