@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1450: (2015-12-08 )
MNKLKVNSVVERKIKSGAQLLEKKDFDTSLVNQLVQLFSQSNQFLGMAYLSPQNKGIGWLLSRQVFDFNHDYFVSLFEKSREKRQKFEKFSQTTAYRLFNQDGDNFGGLTIDFYSDYALFSWYNEFVYTNRQMIVAAFKQVYPNIKGAYEKIRFKGLDFESAHLYGQEAPESFLILENNIKYSVFLNDGLMTGIFLDQHDVRKALATNLSEGKKVLNMFSYTAAFSVAAAVGGALETTSVDLAKRSRELSKAHFDANQIVTDNHRFIVMDVFEYYKYAKRKHLSYDVIVIDPPSFARNKKQTFSVTKDYYKLIEQALDILTPGGTIIASTNAANLTVSQFKKQLEKGFGKASHNYISLQQLPEDFTVNDKDQQSNYLKVFTIKVK
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20.....---.-.--.30-..--......40........50........60.-.-...-..-----.--70.......---.80........90.---.......100.......110.......120.......130---...---......140---..-.--...--.150-----.......160.....----..170.......180........190.......200.......210.......220.......230..--------.....240.......250.......260.......270.......280.......290.......300.......310.......320.......330....-..---.340.-......--350...--...---.360.........370.......380...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNKL
K
V
N
S
V
V
E
R
K
I
K
S
G
A
Q
L
L
E
KKDF---
D
-
T
--
S
L
V
-
N
Q
--
L
V
Q
L
F
SQSN
Q
F
L
G
M
A
Y
LSPQNKG
I
G
W
L
L
S
-
R
-
Q
V
F-DF-----N--
H
D
Y
F
V
S
L
F
E
---
K
S
R
E
K
R
Q
K
F
E
K
F
S
Q
---
T
T
A
Y
R
L
FNQDGDNFG
G
L
T
I
D
FYSD
Y
A
L
F
S
W
Y
N
E
F
VYTN-----
R
Q
M
---
I
V
A
A
F
K
Q
VY---PN-I--
K
G
A
--
Y
E
K
I
-----
R
FKGLDFE
S
A
HLYGQ----EAP
E
S
F
L
I
L
ENN
I
K
-
Y
S
V
F
LNDG
L
M
T
G
I
FL
D
Q
H
D
V
R
K
A
L
A
T
N
L
S
E
G
K
K
V
L
N
M
F
S
Y
T
A
A
F
S
V
A
A
A
VGGA--------LET
T
S
V
D
L
A
K
R
S
R
E
L
S
K
AHFDAN
Q
I
VTDNH
R
F
I
V
M
D
V
F
E
Y
Y
K
Y
A
K
RKHLSY
D
V
I
V
IDPPSFARNKKQTFSV
T
K
D
Y
Y
K
L
I
E
Q
A
L
D
ILTPG
G
T
I
I
A
STNAANL
T
-
V
S
---
Q
F
K
K
Q
-
L
E
K
GFG--KASH
N
Y
--
I
S
L
---
Q
Q--LPEDFTVNDKDQQS
N
Y
L
K
V
F
T
I
K
VK-
48
Fugue
98.45
67%
-92
- C1 -
3LDF
1
?
A:
[1-385]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
S
F
A
E
K
K
L
K
R
G
V
Q
L
L
S
S
R
D
Y
---
P
N
L
--
N
L
D
-
N
Q
--
V
V
Q
L
Y
S
D
A
D
I
F
L
G
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
-
P
-
K
K
V
-
S
L
-----
N
--
V
T
Y
F
I
K
L
F
Q
---
W
S
K
D
K
R
K
N
F
A
H
S
K
L
---
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
G
G
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
S
F
V
Y
Q
I
-----
R
D
E
---
I
V
A
A
F
R
Q
V
Y
---
P
N
-
F
--
L
G
A
--
Y
E
K
I
-----
R
F
N
----
V
S
A
H
L
Y
G
Q
----
E
A
P
E
Q
F
L
I
L
E
N
G
I
S
-
Y
N
V
F
L
N
D
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
--------
M
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
L
D
M
A
N
H
Q
L
V
V
M
D
V
F
D
Y
F
K
Y
A
R
R
H
H
L
T
Y
D
I
I
I
I
D
P
P
S
F
A
R
N
K
E
-
V
F
S
V
S
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
N
M
T
-
V
S
---
Q
F
K
K
Q
-
I
E
K
G
F
G
--
K
Q
K
H
T
Y
--
L
D
L
---
Q
Q
--
L
P
S
D
F
A
V
N
V
Q
D
E
S
S
N
Y
L
K
V
F
T
I
K
V
--
50
Fugue
96.59
66%
-87
- C1 -
2B78
-
?
A:
[1-385]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
S
F
A
E
K
K
L
K
R
G
V
Q
L
L
S
S
R
D
Y
---
P
-
N
--
L
N
L
D
N
Q
--
V
V
Q
L
Y
S
D
A
D
I
F
L
G
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
-
P
-
K
K
V
-
S
L
-----
N
--
V
T
Y
F
I
K
L
F
Q
---
W
S
K
D
K
R
K
N
F
A
H
S
K
L
---
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
G
G
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
S
F
V
Y
Q
I
-----
R
D
E
---
I
V
A
A
F
R
Q
V
Y
---
P
N
-
F
--
L
G
A
--
Y
E
K
I
-----
R
F
N
----
V
S
A
H
L
Y
G
Q
----
E
A
P
E
Q
F
L
I
L
E
N
G
I
S
-
Y
N
V
F
L
N
D
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
--------
M
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
L
D
M
A
N
H
Q
L
V
V
M
D
V
F
D
Y
F
K
Y
A
R
R
H
H
L
T
Y
D
I
I
I
I
D
P
P
S
F
E
V
F
-----
S
V
S
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
N
M
T
-
V
S
---
Q
F
K
K
Q
-
I
E
K
G
F
G
--
K
Q
K
H
T
Y
--
L
D
L
---
Q
Q
--
L
P
S
D
F
A
V
N
V
Q
D
E
S
S
N
Y
L
K
V
F
T
I
K
V
--
27
HHSearch
85.41
42%
-81
- C1 -
3VSE
1
?
A:
[1-388]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
Y
F
N
G
Y
P
L
I
E
E
E
D
I
---
Y
S
Q
DH
L
K
E
-
G
D
--
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
-
Y
-
D
K
A
Q
E
I
-----
N
--
T
A
F
F
V
K
L
F
N
---
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
---
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
I
Y
K
F
-----
K
Y
A
---
I
L
E
A
V
R
K
V
F
---
D
--
Y
--
K
S
I
--
Y
E
K
V
-----
R
F
K
D
S
E
Y
S
G
G
F
V
E
G
D
----
A
P
E
F
P
I
V
I
E
E
N
F
T
F
-
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
S
E
-
A
--------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
-
L
K
---
Q
F
K
N
T
-
I
K
K
T
L
E
E
S
G
V
D
Y
E
L
--
T
E
V
---
M
G
--
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
-
49
Fugue
85.14
41%
-81
- C1 -
3VSE
1
?
A:
[1-390]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Y--
S
-
Q
--
D
H
L
-
K
E
G
D
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
-
Y
D
K
A
Q
-
E
I
-----
N
--
T
A
F
F
V
K
L
F
N
---
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
---
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
I
Y
K
F
-----
K
Y
A
---
I
L
E
A
V
R
K
V
F
---
D
--
Y
--
K
S
I
--
Y
E
K
V
-----
R
F
K
D
S
E
Y
S
G
G
F
V
E
G
D
----
A
P
E
F
P
I
V
I
E
E
N
F
T
F
-
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
--------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
-
L
K
---
Q
F
K
N
T
-
I
K
K
T
L
E
--
E
S
G
V
D
Y
--
E
L
T
---
E
V
M
G
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
H
22
PsiBlast_CBE
84.34
41%
-81
- C1 -
3VSE
1
?
C:
[2-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
A
T
L
N
K
G
K
E
T
K
Y
F
N
G
Y
P
L
I
E
E
E
D
I
YSQ
D
-
H
--
L
K
E
-
G
D
--
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
-
K
A
Q
-
E
I
-----
N
--
T
A
F
F
V
K
L
F
N
---
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
---
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
I
Y
K
F
-----
K
Y
A
---
I
L
E
A
V
R
K
V
F
----
D
-
Y
--
K
S
I
--
Y
E
K
V
-----
R
F
-----
S
G
G
F
V
E
G
-----
D
A
P
E
F
P
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
--------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
-
L
K
---
Q
F
K
N
T
-
I
K
K
T
L
E
--
E
S
G
V
D
Y
E
L
T
E
V
---
M
G
--
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
-
1
PsiBlast_PDB
83.79
41%
-80
- C1 -
3VSE
1
?
A:
[1-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
Y
F
N
G
Y
P
L
I
E
E
E
D
I
YSQ
D
-
H
--
L
K
E
-
G
D
--
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
-
K
A
Q
-
E
I
-----
N
--
T
A
F
F
V
K
L
F
N
---
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
---
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
I
Y
K
F
-----
K
Y
A
---
I
L
E
A
V
R
K
V
F
----
D
-
Y
--
K
S
I
--
Y
E
K
V
-----
R
F
K
D
S
E
Y
S
G
G
F
V
E
G
-----
D
A
P
E
F
P
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
--------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
-
L
K
---
Q
F
K
N
T
-
I
K
K
T
L
E
--
E
S
G
V
D
Y
E
L
T
E
V
---
M
G
--
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
-
21
PsiBlast_CBE
83.29
41%
-80
- C1 -
3VSE
1
?
D:
[2-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
A
T
L
N
K
G
K
E
T
K
Y
F
N
G
Y
P
L
I
E
E
E
D
I
Q--
D
-
H
--
L
K
E
-
G
D
--
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
-
K
A
Q
-
E
I
-----
N
--
T
A
F
F
V
K
L
F
N
---
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
---
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
I
Y
K
F
-----
K
Y
A
---
I
L
E
A
V
R
K
V
F
----
D
-
Y
--
K
S
I
--
Y
E
K
V
-----
R
F
-----
S
G
G
F
V
E
G
-----
D
A
P
E
F
P
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
--------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
-
L
K
---
Q
F
K
N
T
-
I
K
K
T
L
E
--
E
S
G
V
D
Y
EL
T
E
V
---
M
G
--
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
-
23
PsiBlast_CBE
82.22
41%
-78
- C1 -
3VSE
1
?
B:
[1-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
T
L
N
K
G
K
E
T
K
Y
F
N
G
Y
P
L
I
E
E
E
D
I
YSQ
D
-
H
--
L
K
E
-
G
D
--
I
F
Q
I
V
T
D
K
S
Q
Y
V
A
T
A
Y
V
G
R
Q
H
K
G
L
G
W
V
L
T
Y
D
-
K
A
Q
-
E
I
-----
N
--
T
A
F
F
V
K
L
F
N
---
T
A
L
A
E
R
D
Y
Y
F
N
I
D
G
---
T
N
A
F
R
L
F
N
A
E
G
D
G
V
G
G
L
T
I
D
N
Y
D
G
H
L
L
I
Q
W
Y
S
K
G
I
Y
K
F
-----
K
Y
A
---
I
L
E
A
V
R
K
V
F
----
D
-
Y
--
K
S
I
--
Y
E
K
V
-----
R
F
-----
S
G
G
F
V
E
G
-----
D
A
P
E
F
P
I
V
I
E
E
N
F
T
F
Y
N
V
D
L
E
D
G
L
M
T
G
I
F
L
D
Q
K
E
V
R
K
K
L
R
G
Q
Y
A
K
E
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
A
A
-
S
E
A
--------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
L
N
A
I
D
P
K
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
K
Y
A
A
R
H
G
H
S
Y
D
T
I
V
I
D
P
P
S
F
A
R
N
K
K
R
T
F
S
V
Q
K
D
Y
D
K
L
I
N
G
A
L
N
I
L
S
S
E
G
T
L
L
L
C
T
N
A
S
V
Y
P
-
L
K
---
Q
F
K
N
T
-
I
K
K
T
L
E
--
E
S
G
V
D
Y
E
L
T
E
V
---
M
G
--
L
P
K
D
F
K
T
H
P
H
Y
K
P
S
K
Y
L
K
A
V
F
V
N
I
R
-
51
Fugue
66.59
20%
-70
- C1 -
2CWW
3
?
A:
[1-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
Q
V
N
A
K
G
A
A
R
L
L
S
R
H
L
W
V
F
R
R
D
V
---
V
-
S
--
G
P
E
-
T
P
--
G
L
Y
P
V
Y
W
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
L
A
V
R
A
Y
R
-
F
-
A
P
A
-
E
D
-----
P
--
V
A
A
L
L
E
N
L
A
---
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
---
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
H
A
W
E
G
L
-----
L
P
Q
---
V
A
E
A
L
R
P
H
V
---
Q
S
-
V
--
L
A
K
ND
A
R
T
R
-----
E
L
E
G
L
P
L
Y
V
R
P
L
L
G
-----
E
V
P
E
R
V
Q
V
Q
E
G
R
V
R
-
Y
L
V
D
L
------
G
A
Y
L
D
Q
R
E
N
R
L
Y
M
E
R
--
F
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
-
L
G
F
--------
R
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
--
G
N
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
-
E
P
---
L
F
Y
A
M
-
V
A
E
A
A
Q
--
D
A
H
R
L
L
--
R
V
V
---
E
K
R
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-
9
PsiBlast_PDB
65.98
20%
-80
- C1 -
4DMG
1
?
A:
[46-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
F
L
A
V
G
Y
Y
D
P
R
S
R
-----
V
P
-
F
-
R
A
F
-
R
F
D
P
G
P
L
N
--
R
A
F
F
Q
G
R
F
A
---
R
A
L
R
R
R
Q
G
L
--------
G
E
S
H
R
L
V
H
G
E
A
D
G
L
P
G
L
V
V
D
R
F
G
E
V
L
V
L
Q
V
R
S
R
G
M
E
A
L
-----
R
E
V
---
W
L
P
A
L
L
E
V
V
----
A
-
P
--
K
G
V
--
Y
E
R
S
D
V
E
A
R
R
Q
E
G
L
P
E
R
V
G
V
V
Y
G
E
----
V
P
-
E
V
L
E
V
E
E
D
G
L
R
-
F
P
I
P
L
A
L
A
Q
K
T
G
Y
Y
L
D
Q
R
E
N
R
R
L
F
E
A
M
V
R
P
G
E
R
V
L
D
V
Y
S
Y
V
G
G
F
A
L
R
A
A
R
K
G
A
Y
A
L
A
V
D
KD
L
E
A
L
G
V
--------
L
D
Q
A
A
L
R
L
G
L
R
V
D
I
R
H
-------
G
E
A
L
P
T
L
R
G
L
E
G
P
F
H
H
V
L
L
D
P
P
T
L
V
K
R
P
E
E
L
P
A
M
K
R
H
L
V
D
L
V
R
E
A
L
R
L
L
A
E
E
G
F
L
W
L
S
S
C
S
Y
H
L
R
-
L
E
D
L
L
E
V
A
R
R
-
A
A
A
D
L
G
--
R
R
L
R
V
H
--
R
V
T
---
Y
Q
---
P
E
D
H
P
W
S
L
H
I
P
E
S
L
Y
L
K
T
L
V
L
Q
D
D
-
55
Fugue
65.63
25%
-70
- C1 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
A
M
N
S
L
F
A
S
T
A
RGL
E
E
L
L
K
T
E
L
E
N
L
GAVE
C
Q
V
V
QG
G
V
H
F
K
G
D
T
R
L
V
Y
Q
S
L
M
W
SRLAS
R
I
M
L
P
L
G
E
C
K
V
YS
D
L
D
L
Y
L
G
V
Q
AINWTEMFNPG
A
T
F
A
V
H
F
S
G
L
N
DTIRN
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
NLP
R
P
N
V
D
RDAPD
I
R
V
N
V
W
L
H
KE
T
A
S
I
A
L
D
LSGDGLHLRGYRDRAGIAPIK
E
T
L
A
A
A
I
V
M
R
SGWQPG
T
P
L
L
D
PMCGSG
T
L
L
I
E
A
A
M
L
A
T
DRAPGLHRGRWGFSGWAQHD
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
YS
S
H
F
Y
G
S
D
SD
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
GIGEL
I
T
F
E
VKDVAQLTNPLPKGP
Y
G
T
V
L
S
N
P
P
Y
GESE
P
A
L
I
A
L
H
S
L
L
G
R
I
M
K
N
QFGG
W
N
L
S
L
F
S
AS
P
D
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
N
G
P
L
D
C
V
Q
K
N
Y
---
H
-
V
--
A
E
------------------------------------------
S
M
-----
V
--
A
E
D
Y
T
N
R
L
R
---
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
---
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
---
H
K
A
-----
R
Q
R
---
L
F
D
I
I
A
A
T
I
---
S
V
-
L
--
G
I
A
--
P
N
K
L
-----
V
L
K
T
---------
R
E
----
E
K
G
E
F
L
E
V
T
E
Y
N
A
H
-
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
-
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
--------
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
A
-----
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
-
M
D
-------------
L
D
--
G
L
A
K
L
G
--
L
K
A
---
Q
E
--
I
T
Q
K
T
L
S
Q
D
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
-
52
Fugue
63.45
19%
-66
- C1 -
1WXW
-
?
A:
[2-382]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
Q
V
N
A
K
G
A
A
R
L
L
S
R
H
L
W
V
F
R
R
D
V
---
V
-
S
--
G
P
E
-
T
P
--
G
L
Y
P
V
Y
W
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
L
A
V
R
A
Y
R
-
F
-
A
P
A
-
E
D
-----
P
--
V
A
A
L
L
E
N
L
A
---
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
---
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
H
A
W
E
G
L
-----
L
P
Q
---
V
A
E
A
L
R
P
H
V
---
Q
S
-
V
L
A
K
N
D
--
A
R
T
R
-----
E
L
E
G
L
P
L
Y
V
R
P
L
L
G
-----
E
V
P
E
R
V
Q
V
Q
E
G
R
V
R
-
Y
L
V
D
L
-----
R
A
A
Y
L
D
Q
R
E
N
R
L
Y
M
--
E
R
F
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
-
L
G
F
--------
R
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
L
--
G
N
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
--
C
S
H
H
M
T
E
---
P
L
F
Y
A
M
V
A
E
A
A
Q
--
D
A
H
R
L
L
--
R
V
V
---
E
K
R
G
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-
30
HHSearch
62.43
28%
-74
- C1 -
3V97
3
RLMKL_ECOLI
A:
[393-696]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
D
Y
T
N
R
L
R
---
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
---
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
-
N
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
-----
H
K
A
R
Q
R
L
F
D
---
I
I
A
A
T
I
S
V
L
---
G
I
A
P
--
N
K
L
--
V
L
K
T
-----
R
E
------------
E
----
K
-
G
E
F
L
E
V
T
E
Y
N
A
H
-
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
-
M
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
--------
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
---
N
E
Q
F
D
L
I
F
I
D
P
P
T
F
S
-----
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
-
M
D
-----
L
D
G
-
L
A
K
L
----
G
L
K
A
Q
E
--
I
T
Q
---
K
T
--
L
S
Q
D
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
------
24
PsiBlast_CBE
61.97
31%
-101
- C1 -
3V8V
2
RLMKL_ECOLI
B:
[400-657]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
---
H
K
A
-----
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIA
P
N
-
K
--
L
V
L
--
K
T
R
--------------------------
K
G
E
F
L
E
V
T
E
Y
N
A
H
-
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
-
Q
M
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
--------
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
N
----
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
-
M
D
---
L
D
G
L
A
-
K
L
G
L
K
A
--
Q
E
I
T
Q
K
--
T
L
S
---
Q
D
--
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
----------
25
PsiBlast_CBE
61.76
31%
-102
- C1 -
3V97
3
RLMKL_ECOLI
B:
[401-658]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
---
H
K
A
-----
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIA
P
N
-
K
--
L
V
L
--
K
T
R
-------------------------
E
K
G
E
F
L
E
V
T
E
Y
N
A
H
-
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
-
Q
M
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
--------
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
N
----
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
-
M
D
---
L
D
G
L
A
-
K
L
G
L
K
A
--
Q
E
I
T
Q
K
--
T
L
S
---
Q
D
--
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
----------
4
PsiBlast_PDB
60.45
31%
-94
- C1 -
3V8V
2
RLMKL_ECOLI
A:
[400-657]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
P
--
H
K
A
-----
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIA
P
N
-
K
--
L
V
L
--
K
T
R
-------------------------
E
K
G
E
F
L
E
V
T
E
Y
N
A
H
-
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
-
Q
M
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
--------
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
------
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
-
M
D
---
L
D
G
L
A
-
K
L
G
L
K
A
--
Q
E
I
T
Q
K
--
T
L
S
---
Q
D
--
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
----------
5
PsiBlast_PDB
60.42
31%
-95
- C1 -
3V97
3
RLMKL_ECOLI
A:
[401-658]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
E
C
Y
R
L
Y
D
A
D
L
P
E
Y
N
-
V
A
V
D
R
Y
A
D
W
V
V
V
Q
E
Y
A
---
H
K
A
-----
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIA
P
N
-
K
--
L
V
L
--
K
T
R
E
------------------------
E
K
G
E
F
L
E
V
T
E
Y
N
A
H
-
L
W
V
N
L
T
D
Y
L
D
T
G
L
F
L
D
H
R
I
A
R
R
M
L
G
-
Q
M
S
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G
A
--------
R
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
L
T
G
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
N
E
Q
---
F
D
L
I
F
I
D
P
P
T
F
S
-----
A
F
D
V
Q
R
D
H
L
A
L
M
K
D
L
K
R
L
L
R
A
G
G
T
I
M
F
S
N
N
K
R
G
F
R
-
M
D
---
L
D
G
L
A
-
K
L
G
L
K
A
--
Q
E
I
T
Q
K
--
T
L
S
---
Q
D
--
F
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
----------
8
PsiBlast_PDB
59.84
22%
-56
- C1 -
1WXX
5
?
A:
[40-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
-----
L
A
-
V
-
R
A
Y
-
R
F
-----
A
PA
E
D
P
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
---
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
---
Q
A
T
A
H
A
W
-----
E
G
L
---
L
P
Q
V
A
E
A
L
R
---
P
H
-
V
--
Q
S
V
--
L
A
K
N
-----
D
A
R
T
R
E
L
E
G
L
P
L
Y
V
R
P
LLG
E
V
P
E
R
V
Q
V
Q
E
G
R
V
R
-
Y
L
V
D
L
R
A
G
Q
K
T
G
A
Y
L
D
Q
R
E
N
R
--
L
Y
M
E
R
F
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
-
F
--------
R
E
V
V
A
V
D
S
S
A
E
A
--
L
R
R
A
E
E
N
A
R
L
N
G
L
G
N
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
-
E
P
---
L
F
Y
A
M
-
V
A
E
A
-
A
--
Q
D
A
H
R
L
--
L
R
V
V
E
K
R
G
--
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-
6
PsiBlast_PDB
59.62
22%
-56
- C1 -
2CWW
3
?
A:
[40-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
-----
L
A
-
V
-
R
A
Y
-
R
F
-----
A
PA
E
D
P
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
---
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
---
Q
A
T
A
H
A
W
-----
E
G
L
---
L
P
Q
V
A
E
A
L
R
---
P
H
-
V
--
Q
S
V
--
L
A
K
N
-----
D
A
R
T
R
E
L
E
G
L
P
L
Y
V
R
P
LLG
E
V
P
E
R
V
Q
V
Q
E
G
R
V
R
-
Y
L
V
D
L
------
G
A
Y
L
D
Q
R
E
N
R
--
L
Y
M
E
R
F
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
-
F
--------
R
E
V
V
A
V
D
S
S
A
E
A
--
L
R
R
A
E
E
N
A
R
L
N
G
L
G
N
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
-
E
P
---
L
F
Y
A
M
-
V
A
E
A
-
A
--
Q
D
A
H
R
L
--
L
R
V
V
E
K
R
G
--
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-
7
PsiBlast_PDB
58.74
22%
-52
- C1 -
1WXW
-
?
A:
[40-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
-----
L
A
-
V
-
R
A
Y
-
R
F
-----
A
P
A
E
D
P
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
---
E
G
G
Y
R
L
V
H
A
E
G
D
L
L
P
G
L
V
V
D
Y
Y
A
G
H
A
V
V
---
Q
A
T
A
H
A
W
-----
E
G
L
---
L
P
Q
V
A
E
A
L
R
---
P
H
-
V
--
Q
S
V
--
L
A
K
N
-----
D
A
R
T
R
E
L
E
G
L
P
L
Y
V
R
P
LLG
E
V
P
E
R
V
Q
V
Q
E
G
R
V
R
-
Y
L
V
D
L
R
A
-----
A
Y
L
D
Q
R
E
N
R
--
L
Y
M
E
R
F
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
-
F
--------
R
E
V
V
A
V
D
S
S
A
E
A
--
L
R
R
A
E
E
N
A
R
L
N
G
L
G
N
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
R
F
D
L
V
V
L
D
P
P
A
F
A
K
G
K
K
D
V
E
R
A
Y
R
A
Y
K
E
V
N
L
R
A
I
K
L
L
K
E
G
G
I
L
A
T
A
S
C
S
H
H
M
T
-
E
P
---
L
F
Y
A
M
-
V
A
E
A
-
A
--
Q
D
A
H
R
L
--
L
R
V
V
E
K
R
G
--
Q
P
F
D
H
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L
-