@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1509: (2015-12-08 )
MVTIKDVAAKAGVNPSTVSRVLKDNASISSKTKERVKKAMEELGYVPNVAAQMLASGLTQNIGVIFPPLVLPDRLSEPFFMEILSTLTNEAKEHGFTVSIATSMSSEELLEQVKLMHLQKRVDGFIVLYSDQKDPIREYLLKYKLPFVVVGAANGYENEITYIDNDNQLMGKSAIDYLYKKGHKSIQFVTDDLNSEVSEERYLGYFKGARKLGLNQKPALLFDRGNPQVLEEFINRVKEEETTALIVIGDTVSVRVMQFLSFYKLKVPDDISIMTFNNSLFSHLIHPYLSTFDINVNNLGRTSVRRLIDIIKSPDKVFSETIIVPFTLEERESVRDISKNNN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....--..120.......130.......140...-.....150.......160...--....170-.......180.......190....-...200.-......210.---...---.---..--220-----..---...--...230.....--..240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
T
I
K
D
V
A
A
KAGV
N
P
S
T
V
S
R
V
L
KDNASI
S
S
K
T
K
E
R
V
K
K
A
M
E
ELGYV
P
N
V
A
A
Q
M
L
A
S
G
L
TQNI
G
V
IFPPLVLPDRLS
E
P
F
F
M
E
I
L
S
T
L
T
N
E
A
K
EH
G
F
T
V
S
I
ATSM
S
S
E
E
L
L
E
Q
V
K
L
M
H
--
L
Q
K
RVD
G
F
I
V
L
YSDQKD
P
I
R
E
Y
L
L
-KYK-L
P
F
V
V
V
G
AANGYEN
E
I
T
Y
IDN--DNQL
M
G
K
-
S
A
I
D
Y
L
Y
K
KGHK
S
I
Q
F
V
TDDLN
S
E
-
V
S
E
E
R
Y
L
-
G
Y
F
K
G
A
R
KLG---LNQ---K---
P
A
--
L
L
------FD---RG
N
--
P
Q
V
L
E
E
F
I
N
R
V--KEEET
T
A
L
I
V
IGD
T
V
S
V
R
V
M
Q
F
L
S
F
Y
KLKVPD
D
I
S
I
M
T
FN
N
S
L
F
S
H
L
I
H
P
Y
L
S
T
F
D
I
NVNNL
G
R
T
S
V
R
R
L
I
D
I
IKS
P
D
K
V
FS
E
T
I
I
V
P
F
T
L
E
E
R
E
S
V
R
D
ISKNNN
12
PsiBlast_PDB
85.95
26%
-87
- C2 -
1JFT
3
PURR_ECOLI
A:
[1-332]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
A
G
E
A
K
A
D
F
T
D
A
V
I
D
--
N
A
F
E
G
G
Y
-
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
7
PsiBlast_PDB
85.56
27%
-100
- C2 -
1RZR
5
CCPA_BACME
D:
[3-332]
-
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
------
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
--
K
E
L
H
L
L
N
NM
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
E
H
V
E
E
L
K
-
K
S
P
-
V
P
-
V
V
L
A
A
S
I
E
S
T
N
Q
I
P
S
V
T
I
--
D
Y
E
Q
A
A
F
-
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
-
I
N
H
A
K
K
V
K
G
Y
K
R
A
L
T
E
S
G
---
L
P
V
---
R
---
D
S
--
Y
I
VEGDYT
Y
D
---
S
G
---
I
E
A
V
E
K
L
L
E
----
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
-
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
K
-------
4
PsiBlast_PDB
85.13
27%
-101
- C2 -
1ZVV
4
CCPA_BACSU
A:
[3-332]
-
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
------
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
--
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
E
H
V
E
E
L
K
-
K
S
P
-
V
P
-
V
V
L
A
A
S
I
E
S
T
N
Q
I
P
S
V
T
I
--
D
Y
E
Q
A
A
F
-
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
-
I
N
H
A
K
K
V
K
G
Y
K
R
A
L
T
E
S
G
---
L
P
V
---
R
---
D
S
--
Y
I
V
E
G
D
YT
Y
D
---
S
G
---
I
E
A
V
E
K
L
L
E
----
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
-
E
T
V
D
S
S
I
V
E
L
P
H
R
I
E
F
R
Q
S
T
K
-------
40
HHSearch
84.92
25%
-88
- C2 -
1QPZ
2
PURR_ECOLI
A:
[1-335]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
------
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
E
Y
R
H
-
I
P
M
V
V
M
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
--
N
A
F
E
G
G
Y
-
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
A
M
E
E
A
M
---
I
K
V
---
P
ESW
I
V
Q
G
D
F
------
E
P
---
E
S
G
--
Y
R
A
M
Q
Q
I
L
S
Q
P
--
H
--
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
-
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
9
PsiBlast_PDB
84.74
27%
-86
- C2 -
1QP7
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
10
PsiBlast_PDB
83.75
27%
-83
- C2 -
1QQA
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
8
PsiBlast_PDB
83.22
27%
-84
- C2 -
1BDH
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
11
PsiBlast_PDB
82.99
27%
-84
- C2 -
1QQB
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
1
PsiBlast_PDB
82.95
30%
-102
- C2 -
3K4H
1
?
A:
[7-284]
---------------------------------------------------------
T
T
K
T
L
G
L
V
M
P
S
S
A
-
S
K
A
F
Q
N
P
F
F
P
E
V
I
R
G
I
S
S
F
A
H
V
E
G
Y
A
L
Y
M
S
T
G
E
T
E
E
E
I
F
N
G
V
V
K
M
V
--
Q
G
R
Q
I
G
G
I
I
L
L
Y
S
R
E
N
D
R
I
I
Q
Y
L
H
-
E
Q
N
-
F
P
F
V
L
I
G
K
P
Y
D
R
K
D
E
I
T
Y
V
D
N
--
D
N
Y
T
A
A
R
-
E
V
A
E
Y
L
I
S
L
G
H
K
Q
I
A
F
I
G
G
G
S
D
L
L
-
V
T
R
D
R
L
A
-
G
M
-
S
D
A
L
K
L
A
D
I
V
L
P
K
---
E
---
Y
I
--
L
H
------
F
D
FS
R
E
S
G
--
Q
Q
A
V
E
E
L
M
G
L
----
Q
Q
P
P
T
A
I
M
A
T
D
D
L
I
G
L
G
V
L
S
A
L
S
K
K
G
F
V
V
P
K
D
V
S
I
V
S
F
N
N
A
L
L
S
E
I
A
S
P
P
L
S
T
V
D
V
N
I
Y
Q
L
G
Y
E
A
A
K
A
L
V
D
K
V
E
N
A
E
S
T
-
A
K
C
I
I
I
P
H
K
L
L
K
R
Q
T
C
E
G
H
H
----
20
PsiBlast_PDB
82.54
26%
-84
- C2 -
1PNR
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
14
PsiBlast_PDB
82.51
26%
-79
- C2 -
2PUB
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
17
PsiBlast_PDB
82.47
26%
-83
- C2 -
2PUE
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
LS
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
16
PsiBlast_PDB
82.47
26%
-82
- C2 -
2PUD
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
18
PsiBlast_PDB
82.45
26%
-84
- C2 -
2PUF
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
LS
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
13
PsiBlast_PDB
82.31
26%
-82
- C2 -
2PUA
2
PURR_ECOLI
A:
[1-332]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
19
PsiBlast_PDB
82.20
26%
-86
- C2 -
2PUG
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
LS
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
15
PsiBlast_PDB
82.00
26%
-82
- C2 -
2PUC
2
PURR_ECOLI
A:
[2-332]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
------
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
--
A
Q
K
R
V
D
G
L
L
V
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
---
D
W
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
-
T
G
A
G
R
L
A
-
G
F
M
K
-
A
M
E
E
A
---
M
I
K
---
V
---
P
E
--
S
W
------
I
V
---
Q
G
D
FE
P
E
S
G
Y
R
A
M
Q
Q
I
LS
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
-
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
R
D
Y
5
PsiBlast_PDB
81.84
27%
-94
- C2 -
2HSG
-
CCPA_BACME
A:
[3-332]
-
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
-
K
T
T
T
V
G
V
I
I
P
--------
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
--
K
E
L
H
L
L
N
NM
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
E
H
V
E
E
L
K
-
K
S
P
-
V
P
-
V
V
L
A
A
S
I
E
S
T
N
Q
I
P
S
V
T
I
--
D
Y
E
Q
A
A
F
-
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
-
I
N
H
A
K
K
V
K
G
Y
K
R
A
L
T
E
S
G
---
L
P
V
---
R
---
D
S
--
Y
I
V
E
G
DYT
Y
D
---
S
G
---
I
E
A
V
E
K
L
L
E
----
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
-
E
T
V
D
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
K
-------
52
HHSearch
80.61
29%
-94
- C2 -
3K4H
1
?
A:
[7-288]
---------------------------------------------------------
T
T
K
T
L
G
L
V
M
P
S
S
A
-
S
K
A
F
Q
N
P
F
F
P
E
V
I
R
G
I
S
S
F
A
H
V
E
G
Y
A
L
Y
M
S
T
G
E
T
E
E
E
I
F
N
G
V
V
K
M
V
--
Q
G
R
Q
I
G
G
I
I
L
L
Y
S
R
E
N
D
R
I
I
Q
Y
L
H
-
E
Q
N
-
F
P
F
V
L
I
G
K
P
Y
D
R
K
D
E
I
T
Y
V
D
N
--
D
N
Y
T
A
A
R
-
E
V
A
E
Y
L
I
S
L
G
H
K
Q
I
A
F
I
G
G
G
S
D
L
L
-
V
T
R
D
R
L
A
-
G
M
S
D
A
L
K
L
A
D
---
I
V
L
P
KE
Y
---
I
L
H
F
D
F
------
S
R
---
E
S
G
--
Q
Q
A
V
E
E
L
M
G
L
Q
--
Q
--
P
P
T
A
I
M
A
T
D
D
L
I
G
L
G
V
L
S
A
L
S
K
K
G
F
V
V
P
K
D
V
S
I
V
S
F
N
N
A
L
L
S
E
I
A
S
P
P
L
S
T
V
D
V
N
I
Y
Q
L
G
Y
E
A
A
K
A
L
V
D
K
V
E
N
A
E
S
-
T
A
K
C
I
I
I
P
H
K
L
L
K
R
Q
T
C
E
G
H
H
----
35
HHSearch
80.51
26%
-94
- C2 -
2HSG
-
CCPA_BACME
A:
[2-332]
N
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
-
K
T
T
T
V
G
V
I
I
P
--
S
------
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
--
L
G
K
Q
V
D
G
I
I
F
M
S
G
N
V
T
E
E
H
V
E
E
L
K
-
K
S
P
-
V
P
V
V
L
A
A
S
I
E
S
-
T
N
Q
I
P
S
V
T
I
--
D
Y
E
Q
A
A
F
-
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
N
H
A
K
K
V
K
-
G
Y
K
R
A
L
T
E
S
G
---
L
P
V
---
R
DSY
I
V
E
G
D
Y
------
T
Y
---
D
S
G
--
I
E
A
V
E
K
L
L
E
E
D
--
E
--
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
-
D
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
K
-------