@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1530: (2015-12-08 )
MIENFLEKNILNKVKLLTLCYDTPSLSLDTACNRLHLSPVELKNYCHKLNVLFGHKLSIHIQKERILCKLNKLTQEDALKIVYNESNTLQLLKFLIDDSSDKKSLVAFGNDLFLSRSSVYRLRENLIPLIKDLGLSLSKNTIVGDEYRIRYLIAYLTTKFGIKIYDLSALDIKIIRQFLFESGTNIRPTTHLSDIFIFFDTLFILTWKRHHHKVKIPNSKLFSSLKKIFIYEELNTCVKSIVQPYFNVIFNSEDMDYIFLIYLTSANSFAAQKWTETHVDEVLAIFKSLPKFQMLLQPLKEALPYSDTYYDELVKVTIYFSRNFIVGLNQLIPETLSFPSTFYPGNNPKLISIIEPIVTHWLTEIGESKFKKTHFFLLCAHLERVIKNSMPPINIVLLTTDFINNEILKDYILQSLSTDKIRFHSYYLLTDNISQISTLKPDLIITNRKLFTYVTKELATNSLVAHIDYNDTPSQISNIQTIISNIKEEKYRKIFDKI
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.....-...-.10........20.-.--......--30...-.....40........50.....-.-..60---........70........80------........90........100.......110.......120...----....130.......140.......150.......160.......170.......180.......190.......200.......210.......220...--....230----.........240.......250......----.-260.......270-.......280-........290.......300.......310.......320.......330......---...340.......350.......360.......370.......380.......390---.......400-....-...410......--.420.......430.......440........450.......460-.......470...---------....480.......-----490......---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
N
F
-
L
E
K
-
N
I
L
N
K
V
K
L
L
T
L
C
YD-T--PSL
S
L
D
--
T
ACNR-LHL
S
P
V
E
L
K
N
Y
C
H
K
L
N
V
L
FG
H
K
-
L
-
S
I
H
I
---
Q
K
E
R
I
L
C
K
L
N
KL
T
Q
E
D
A
L
K
I
------
V
YNES
N
T
L
Q
L
L
K
F
L
IDDSSDK
K
S
L
V
AFGN
D
L
FL
S
R
S
S
V
Y
R
L
R
E
N
----
L
I
P
L
I
K
D
LGLSLSKNTIVG
D
E
Y
R
I
R
Y
L
I
A
Y
L
TTKF
G
I
K
I
Y
D
LSA
L
D
I
K
I
I
R
Q
F
L
F
ESGTNIRPTTH
L
S
D
I
F
I
F
F
D
T
L
F
I
L
T
WKRH
H
H
K
V
KIP
N
S
K
L
F
S
S
L
--
K
K
I
F
I
------
Y
E
E
L
N
T
C
V
K
S
I
V
Q
P
Y
F
N
V
IFNSEDM
D
Y
I
----
F
-
L
I
Y
L
TSAN
S
F
A
A
Q
-
K
W
T
E
T
H
V
D
E
--
V
L
A
I
F
KSL
P
K
F
Q
M
L
L
Q
P
L
K
E
ALPYS
D
T
Y
Y
D
E
L
V
K
V
T
I
Y
FSR
N
F
I
V
G
L
N
Q
--L
I
P
E
TL---SFPSTFYPGNN
P
K
L
I
S
I
I
E
P
I
V
T
H
W
L
T
E
I
G
E
S
KFKK
T
H
F
F
L
L
C
A
H
L
E
R
V
I
K
NSMPP---
I
N
I
V
L
L
T
T
D
F-I
N
N
E
-
I
L
K
D
Y
I
L
Q
SLST--D
K
I
R
F
H
S
Y
Y
L
L
TDN
I
S
Q
I
STLK-P
D
L
I
I
TN
R
K
L
F
T
Y
V
T
K
E
LATN
S
-
L
V
A
H
I
DYND
T
P
S
Q
---------
I
S
N
I
Q
T
I
I
S
N
I
K
E
E
-----
K
Y
R
K
I
F
DKI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
65.44
20%
-63
- C5 -
4B3X
3
IF2_THET8
A:
[1-363]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
R
I
Y
Q
L
A
K
E
-
L
-----------------
G
M
E
T
Q
E
L
L
E
L
L
D
Q
M
G
V
A
Y
K
S
H
-
A
-
S
-------------
T
L
E
E
K
D
A
E
A
V
R
E
L
------
V
K
E
Q
R
G
L
Q
E
K
L
A
E
E
E
R
R
K
S
L
P
R
------------
R
P
P
V
V
V
I
M
G
H
----
V
D
H
G
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
-------------
G
G
G
I
T
Q
H
V
G
A
F
E
V
K
T
P
Q
-----------------
G
T
V
V
F
I
D
T
---------------
P
G
H
E
A
F
T
T
I
--
R
Q
-----------------------------
R
G
A
K
V
A
D
I
----
A
-
V
I
V
I
A
A
D
D
G
I
M
-------
P
Q
T
E
E
--
A
I
A
H
A
K
A
-
A
G
A
K
L
I
F
A
I
N
K
I
D
L
P
Q
A
D
---
P
E
K
V
K
R
Q
L
M
E
-
R
G
F
V
---------
P
E
E
Y
---
G
G
----------------
D
A
I
V
I
P
I
S
A
K
T
G
Q
G
V
Q
D
L
L
E
M
I
L
L
L
A
E
L
E
D
Y
R
A
D
P
N
A
E
---
P
R
G
V
I
L
E
S
K
L
-
D
K
Q
A
G
I
I
A
N
M
L
V
Q
E
-----
G
T
F
R
V
G
D
Y
V
V
A
G
E
A
Y
G
R
I
R
A
M
M
--
D
A
D
G
N
Q
R
K
-------
E
A
G
P
G
S
-
A
V
Q
V
L
G
F
Q
E
L
P
H
A
G
D
V
V
E
W
V
PD
L
E
A
A
K
E
I
A
E
E
R
K
E
E
-----
R
K
A
R
E
E
E
E
K
A
RRPRTMAELLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
59.43
18%
-43
* C6 *
4OV8
9
?
A:
[6-472]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
-
L
N
D
-
V
I
Q
D
P
T
R
R
N
K
L
I
N
D
-
N
--
N
L
L
K
G
I
--
I
M
G
R
D
G
P
V
P
S
S
R
E
L
I
V
R
P
D
T
L
R
A
I
I
N
N
R
-
A
-
T
I
E
T
---
T
T
M
E
-----
A
E
F
T
-
E
T
L
M
E
S
------
N
Y
N
-
S
A
S
V
K
V
S
A
P
C
I
T
A
N
S
E
Y
S
E
S
S
S
F
K
N
T
E
--
T
E
K
S
M
Y
T
S
S
R
Y
----
L
F
P
Q
G
R
I
D
F
T
T
P
D
S
G
D
V
I
K
L
S
P
Q
F
T
S
G
V
Q
A
A
L
A
K
------
A
T
G
T
E
K
R
E
A
L
Q
N
L
F
Q
E
Y
G
C
V
F
R
T
K
V
H
I
G
-
G
V
L
S
A
H
T
M
E
T
F
S
R
S
E
N
E
T
E
V
K
Q
D
V
K
A
G
L
E
G
A
--
V
K
G
W
G
G
GATAG
H
G
N
T
Q
G
T
I
T
T
S
Q
N
R
K
L
N
V
K
Y
I
V
N
G
G
D
Y
T
KIQN
T
-
E
E
W
V
A
S
T
N
Q
--
S
E
-
H
W
R
V
I
E
V
T
E
--
V
T
A
V
A
D
L
L
P
--
Q
P
I
R
G
Q
V
K
D
L
L
K
P
L
L
G
K
W
V
D
V
E
K
V
P
---------
G
L
E
S
--
L
-
P
V
S
V
---
Y
R
P
K
G
A
I
P
A
G
W
------------
F
W
L
---
G
D
T
A
D
A
S
K
A
L
L
V
K
P
T
L
P
A
R
S
G
R
N
--
P
A
---
L
T
S
L
H
Q
G
S
G
M
-
T
E
Q
P
-
F
V
D
L
P
Q
Y
Q
Y
L
S
T
-----
Y
F
G
S
F
A
H
D
T
P
P
G
S
T
L
R
G
L
R
-
P
D
H
V
L
P
G
R
Y
E
M
H
G
D
T
I
S
T
A
V
Y
--
V
T
R
P
V
D
V
P
F
P
E
D
E
---------
A
F
D
L
K
S
L
V
R
V
K
L
P
G
SGNPP
K
P
R
S
A
L
K
K
S
MVLFD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
57.76
17%
-47
* C5 *
4BWZ
2
?
A:
[3-386]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
H
L
-
L
E
I
F
Y
L
L
L
A
A
Q
V
C
A
F
I
F
K
-
R
--
L
N
---------------
Q
P
V
V
I
G
E
V
--
L
A
G
V
L
V
G
P
A
-
L
-
L
G
L
V
---
H
E
G
E
I
L
E
F
L
A
E
L
G
A
V
F
L
L
F
M
------
V
G
L
E
T
R
----
L
K
D
I
L
A
V
G
K
E
A
F
L
V
A
V
L
G
V
A
L
P
F
L
G
G
Y
L
Y
G
L
E
I
G
----
F
------------------
E
T
L
P
A
L
F
L
G
T
A
L
V
-----------
A
T
S
V
G
I
T
A
R
V
L
Q
E
L
G
V
L
S
R
----------------------------------------------------------------
P
Y
S
R
I
I
L
G
A
A
V
I
D
D
V
----
L
G
L
I
V
L
A
C
V
N
G
V
A
E
T
G
Q
V
E
V
G
A
I
T
R
--
L
I
V
L
S
V
V
F
V
G
L
A
V
F
L
S
T
L
I
A
R
L
P
L
E
R
L
P
V
G
S
P
L
G
F
A
L
A
L
G
V
G
M
A
A
L
A
A
S
I
G
L
A
P
I
V
G
---
A
F
L
G
G
M
L
L
S
E
V
R
E
K
Y
R
L
E
E
P
I
F
A
I
------
E
S
F
L
A
P
I
F
F
A
M
V
G
V
R
L
E
L
S
A
L
A
S
P
V
V
---
L
V
A
G
T
V
V
T
V
I
-
A
I
L
G
-
K
V
L
G
G
F
L
G
A
L
T
Q
--
G
V
R
S
A
L
T
V
G
C
G
M
A
P
R
G
E
V
G
L
I
V
-
A
A
L
G
L
K
A
G
------
A
V
N
E
E
E
Y
A
-
I
V
L
F
M
V
V
F
T
T
L
F
A
---------
P
F
A
L
K
P
L
I
A
W
T
E
R
E
-----
R
A
A
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
52.14
19%
-55
- C1 -
4JSP
3
MTOR_HUMAN
A:
[10-1174]
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
GPT
P
A
I
L
E
S
L
I
S
I
N
N
K
L
QQ
P
E
A
A
A
G
V
L
E
Y
A
M
K
H
FGELEI
Q
A
T
W
Y
E
K
L
HE
W
E
D
A
L
V
A
Y
D
K
K
M
D
T
N
KDD
P
E
L
M
L
G
R
M
R
C
L
E
A
L
GE
W
G
Q
L
H
Q
Q
C
C
E
K
WTLVN
D
E
T
Q
A
K
M
A
R
M
A
A
A
A
A
W
G
L
GQ
W
D
S
M
E
E
Y
T
C
M
IPRDT
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
DL
F
S
L
A
Q
Q
C
I
D
K
A
R
D
L
L
D
A
E
L
T
A
M
AGESYS
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
L
E
E
V
I
Q
Y
K
LVPER
R
E
I
I
R
Q
I
W
W
E
R
L
QG
C
Q
R
I
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
VSPHED
M
R
T
W
L
K
Y
A
S
L
C
G
K
S
GR
L
A
L
A
H
K
T
L
V
L
L
L
GVDPSRQLD
H
P
L
P
TVH
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
AR
K
I
D
A
F
Q
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
QHAIATED
Q
Q
H
K
Q
E
L
H
K
L
M
A
R
C
F
L
K
L
G
E
W
Q
L
N
L
QGINEST
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
DRSW
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
L
H
Y
K
H
Q
N
Q
A
R
D
E
KK
K
V
T
E
D
L
-
S
K
T
-
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
-
S
--
I
S
L
S
R
G
--
N
N
-----------
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
-
H
-
W
------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
--------
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
--------------------
A
R
I
D
T
P
R
P
L
----
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
-------
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
R
V
A
I
L
----
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
--
R
N
V
K
G
------
M
F
E
V
L
E
P
L
H
A
M
M
E
R
------
G
P
Q
T
L
K
E
T
----
S
-
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
-
E
W
C
R
K
Y
M
K
S
GN
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
------------
E
L
---
A
V
P
G
T
Y
D
P
N
Q
P
I
I
R
I
Q
S
I
A
P
-------------------------
S
L
Q
V
I
T
S
K
Q
R
P
---
R
K
L
T
L
M
G
-----
S
N
G
-
H
E
F
V
F
L
L
K
G
H
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
----
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
---------------
L
H
A
L
I
R
D
Y
R
E
K
-----
K
--
K
I
L
L
N
I
E
H
R
I
M
L
R
M
APDYDHLT
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
AGD
D
L
A
K
L
L
W
L
K
SPS
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
GLGDRHPSNLMLDRLSG
K
I
L
H
I
DFGDCFEVAMTREKFPEKIPFRLT
R
M
L
T
N
A
M
EVTGLDG
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
DPLLNWRLMDTNTA
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
GRDFSHDDTLD
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
CYIGWCPFW
29
HHSearch
46.09
9%
-51
- C4 -
1VKR
-
PTM3C_ECOLI
A:
[375-471]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
V
---
R
K
I
I
V
A
C
D
A
G
M
G
S
S
A
-
M
G
A
G
V
L
R
K
K
I
Q
D
--
A
G
L
S
Q
I
S
V
T
N
S
A
I
N
--
N
L
-
P
P
D
-
V
D
L
V
I
T
H
R
D
L
T
E
R
-
A
M
R
Q
V
P
Q
A
-
Q
H
I
S
L
T
N
F
L
D
S
G
L
---------
Y
T
S
L
T
E
R
L
V
A
A
Q
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
43.25
8%
-81
- C4 -
1O57
3
PURR_BACSU
A:
[4-74]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
R
S
G
R
L
V
D
L
T
N
Y
L
L
T
-
H
PH
E
L
I
P
L
T
--
F
F
S
E
R
-
Y
E
S
A
K
S
S
I
S
E
D
L
T
I
I
K
Q
T
F
E
Q
Q
G
I
G
T
L
L
T
V
P
G
A
A
G
G
V
K
Y
I
P
K
M
K
Q
A
E
A
E
E
F
V
------
Q
T
L
G
Q
S
L
A
N
P
E
R
I
L
P
G
G
Y
V
Y
L
T
D
I
L
G
K
P
S
V
L
S
K
V
G
K
L
F
A
S
V
F
A
E
----
R
E
I
D
V
V
M
T
V
A
T
K
G
I
P
L
A
Y
A
A
A
S
Y
L
N
V
P
V
V
I
V
R
K
D
G
S
T
V
S
I
N
Y
V
S
G
S
S
N
R
I
Q
T
M
S
L
A
K
R
S
M
K
T
G
S
N
V
L
I
I
D
D
F
M
K
A
G
G
T
I
N
G
M
I
N
L
L
D
E
F
N
A
N
V
A
G
I
G
V
L
V
--
E
A
E
G
V
------
D
E
R
L
V
D
E
Y
M
S
L
L
T
L
S
T
I
N
M
K
E
K
S
I
E
I
Q
N
----
G
-
N
F
L
R
F
F
K
D
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
43.18
31%
-5
- C4 -
4HCB
2
EX1_ECOLI
A:
[257-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
----
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
--
W
Q
Y
A
D
------
E
I
V
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
43.08
31%
-11
- C4 -
4HCB
3
EX1_ECOLI
B:
[257-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
----
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
--
W
Q
Y
A
D
------
E
I
V
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
42.96
12%
-102
- C4 -
1BIA
-
BIRA_ECOLI
A:
[4-63]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
V
P
L
K
L
I
A
L
L
A
N
-
G
--
E
F
H
S
G
E
--
Q
L
G
E
T
-
L
G
M
S
R
A
A
I
N
K
H
I
Q
T
L
R
D
W
---
G
-
V
-
D
V
F
T
V
--
P
G
K
G
Y
S
L
P
E
P
I
Q
L
L
N
A
K
Q
I
L
------
G
Q
L
D
G
G
S
V
A
V
L
P
V
I
D
S
T
N
Q
Y
L
L
D
R
I
G
E
L
K
S
G
D
A
C
I
A
E
Y
Q
Q
A
G
S
P
----
F
G
A
N
L
Y
L
S
M
F
W
R
L
E
Q
P
A
A
A
I
G
L
S
L
V
I
G
I
V
M
A
E
V
L
R
K
L
G
A
D
K
V
R
V
K
W
P
N
D
L
Y
L
Q
D
R
K
L
A
G
I
L
V
E
L
T
G
A
A
Q
I
V
I
G
A
G
I
N
M
A
M
W
I
T
L
Q
E
A
G
I
N
L
D
R
N
T
L
A
A
M
L
--
I
R
E
L
R
------
A
A
L
E
L
F
E
Q
E
G
L
A
P
Y
L
S
R
W
E
K
L
D
N
F
I
N
R
P
----
V
-
K
L
I
I
G
D
K
E
I
F
G
I
S
-
R
G
I
D
K
Q
G
A
L
--
L
L
E
Q
D
G
I
I
K
P
W
M
G
G
E
I
S
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
42.70
11%
-40
- C2 -
1FUR
1
FUMC_ECOLI
A:
[4-459]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
S
E
K
-
D
S
M
G
A
I
D
V
P
----
A
-
D
--
K
L
W
G
A
Q
--
T
Q
R
S
L
-
E
H
F
R
I
S
--
T
E
K
M
-
P
T
S
-
L
I
H
A
L
-
A
-
L
T
K
R
---
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
-
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
GMER
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
-
A
A
L
L
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
--
A
D
I
V
K
I
G
R
T
-
N
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
--
A
E
L
A
L
GG----
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
----
F
-
V
T
A
P
N
K
F
E
A
L
A
T
C
-
D
A
L
V
Q
A
H
G
A
--
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
-
P
R
C
G
I
G
E
I
S
I
P
E
-
N
E
P
G
S
S
I
M
P
G
K
V
N
P
--
T
Q
C
E
A
L
---
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
GIE
P
N
R
E
R
I
N
Q
L
L
-
N
E
S
L
-
M
L
V
T
A
L
N
T
H
I
G
-----------
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
-----
G
Y
L
S
E
A
E
-
F
D
S
W
V
R
P
E
Q
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
42.52
31%
-13
- C4 -
4HCC
2
EX1_ECOLI
B:
[257-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
F
T
P
S
D
N
V
D
A
Q
L
Y
N
G
----
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
Y
--
A
D
E
I
V
------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
42.31
31%
-15
- C4 -
4HCC
2
EX1_ECOLI
A:
[257-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
Y
N
----
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
--
Y
A
D
E
I
------
V
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
42.30
31%
-7
- C4 -
4JRQ
2
EX1_ECOLI
A:
[260-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
T
P
S
D
N
V
D
A
Q
L
Y
N
G
----
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
Y
--
A
E
E
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
41.69
31%
-7
- C4 -
4JRQ
2
EX1_ECOLI
B:
[260-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
P
S
D
N
V
D
A
Q
L
Y
N
G
F
----
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
Y
A
--
E
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
41.24
31%
-11
- C4 -
4JRP
2
EX1_ECOLI
B:
[260-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
----
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
--
W
Q
Y
A
E
------
E
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
41.02
10%
-100
- C4 -
1H99
-
LICT_BACSU
A:
[70-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
M
E
V
S
E
E
I
I
S
Y
A
K
L
Q
L
G
K
K
-
L
N
D
S
I
Y
V
S
L
T
D
H
I
N
F
A
I
Q
R
N
Q
K
G
L
D
I
K
N
A
L
-
L
W
E
T
K
R
L
Y
K
D
E
------
F
A
I
G
K
E
-
A
L
V
M
V
K
N
K
T
G
V
S
L
P
E
D
E
A
G
F
I
----
A
-
L
H
I
V
N
A
E
L
N
E
E
---
M
-----------
P
N
I
I
N
I
T
K
V
M
E
E
I
L
S
I
V
K
Y
H
F
K
I
E
F
N
E
E
S
L
H
Y
Y
R
F
V
T
D
L
K
F
F
A
Q
R
L
F
N
--
G
T
H
M
--EDD
F
L
-
L
D
T
V
K
E
K
Y
H
R
A
Y
E
C
T
K
K
I
Q
T
Y
I
E
R
E
Y
E
H
K
-
L
T
S
D
E
L
L
Y
L
T
I
D
I
E
R
V
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
40.75
9%
-87
* C4 *
1J5Y
1
NIAR_THEMA
A:
[15-79]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
K
T
V
-
R
Q
E
R
L
K
S
I
V
R
I
L
E
R
S
K
--
E
P
V
S
G
A
--
Q
L
A
E
E
-
L
S
V
S
R
Q
V
I
V
Q
D
I
A
Y
L
R
S
L
---
G
-
Y
-
N
I
V
A
---
T
P
R
G
Y
V
L
A
G
G
K
S
G
V
S
R
L
V
A
V
------
K
H
A
P
E
E
I
K
E
E
L
L
C
V
V
R
N
G
G
R
I
V
D
V
I
V
E
H
P
V
Y
G
E
I
R
G
I
I
D
V
S
S
E
E
----
E
V
L
K
F
V
N
L
M
E
M
A
K
T
E
P
L
L
T
L
S
G
G
V
H
L
H
T
I
E
A
P
D
E
E
T
M
E
R
I
M
R
E
L
K
K
K
G
F
L
I
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
40.60
31%
-26
- C4 -
1FXX
2
EX1_ECOLI
A:
[257-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
---------
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
P
S
D
N
V
D
A
Q
L
Y
N
G
F
----
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
Y
A
--
D
E
I
V
E
------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.42
31%
-10
- C4 -
4JS4
2
EX1_ECOLI
A:
[260-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
E
P
F
T
P
S
D
N
V
D
A
Q
L
----
Y
N
G
F
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
--
W
Q
Y
A
E
------
E
I
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
40.28
31%
-9
- C4 -
4JS5
2
EX1_ECOLI
A:
[260-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
V
I
M
V
D
L
A
G
D
I
S
--
P
L
L
E
L
D
S
D
T
L
R
E
R
-
L
Y
T
A
K
T
D
L
G
D
-----
N
A
A
V
P
V
K
-
L
--
V
H
I
---
N
K
C
P
V
L
A
Q
A
N
T
L
R
P
E
D
A
D
R
L
------
G
I
N
R
Q
H
C
L
D
N
L
K
I
L
R
E
N
P
Q
V
R
E
K
V
V
A
I
F
A
E
A
P
S
D
N
V
D
A
Q
L
Y
N
G
F
----
F
S
D
A
D
R
A
A
M
K
I
V
L
E
T
E
P
R
N
L
P
A
L
D
I
T
F
V
D
K
R
I
E
K
L
L
F
N
Y
R
A
R
N
F
P
G
T
L
D
Y
A
E
Q
Q
R
W
L
E
H
R
R
Q
V
F
T
P
E
F
L
Q
G
Y
A
D
E
L
Q
M
L
V
Q
Q
Y
A
D
D
K
E
K
V
A
L
L
K
A
L
W
Q
Y
A
--
E
E
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------