@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1537: (2015-12-08 )
MSMFLDTAKISVKAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFKVNEGLRTLMDFRYNRNFKAKAGEKGMTKGMHGRGAEDLIVSLPPGTTVRDATTGKVITDLVEHDQEFVVARGGRGGRGNIRFATPRNPAPEIAENGEPGEERELQLELKILADVGLVGFPSVGKSTLLSVVSAAKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVILHVIDMSASEGRDPYDDYVSINNELETYNLRLMERPQIIVANKMDMPDSEENLAAFKEKLAANYDEFDDMPMIFPISSLAHQGLENLMDATAELLANTEEFLLYDETDMQEDEAYYGFNEDERPFEITRDDDATWVLYGDKLEKLFVMTNMERDESIMKFARQLRGMGVDEALRERGAKDGDIVRIGNFEFEFVD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.....-----..180....-...190.......--200.....--------------------..210.......220.--.---.---..--..230..----......240.......250.---......260.......270--------------------------------------------------------........--280.......290.---..----......300.......310.......320.......330.......340........350.......360.......370.......380.......390.......400.......410.......420.......430.....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
M
F
L
D
T
A
K
I
S
V
K
AGRGGDG
M
V
A
F
R
REKYVPNGGPWGGDGGKG
G
S
V
I
F
KV
N
E
G
L
R
T
L
M
D
F
RYNRNFKAKAGEKGMTKGMHGRGAE
D
L
I
V
SLPPGTTVRDATT
G
K
V
I
T
D
L
V
EHDQ
E
F
V
V
ARGGRGGRG
N
I
R
FATPRNPAPEIAENGEPGEE
R
E
L
Q
L
E
L
K
I
L
A
DVGLVGFPSV
G
K
S
T
L
L
-----
S
V
V
S
AAKPK-IG
A
Y
H
F
T
T
IVPNL--G
M
V
RTKSG--------------------DSF
A
M
A
D
L
P
G
L
I
E
GAS--Q---G---
V
G
--
L
G
T
-
Q
F
L
----
R
H
I
E
R
T
R
V
I
L
H
V
I
DMSASEG---RDPYDD
Y
V
SINNEL
E
T
Y
N
---------------------------------------------------------
L
R
L
MERP
Q
--
I
I
V
A
NKMDMPD--S---
E
E
----
N
L
A
A
F
K
E
K
LAANYDEFDDM
P
M
I
F
P
I
S
S
L
A
H
Q
G
L
E
N
L
M
D
A
T
A
E
L
LANTE-
E
F
L
L
YDETDMQEDEAYYGFNEDER
P
F
E
I
TRDDD
A
T
W
V
L
YGD
K
L
E
K
L
F
V
MTNMER
D
E
S
I
M
K
F
A
R
Q
L
RGM
G
V
D
E
A
L
R
ERGAKDG
D
I
V
R
IGN
F
E
F
E
FVD--
57
Fugue
89.82
43%
-58
- C1 -
1UDX
3
OBG_THET8
A:
[1-416]
--
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
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Y
K
A
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E
H
G
R
G
S
Q
Q
H
G
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G
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D
L
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L
L
A
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L
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E
G
Q
T
V
L
V
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R
G
G
A
G
G
R
G
N
M
H
F
V
S
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Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
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R
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L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
K
-
I
A
P
Y
P
F
T
T
L
S
P
N
L
--
G
V
V
E
V
S
E
E
--------------------
E
R
F
T
L
A
D
I
P
G
I
I
E
G
A
S
--
E
---
G
---
K
G
--
L
G
L
-
E
F
L
----
R
H
I
A
R
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R
V
L
L
Y
V
L
D
A
A
-------
D
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
D
---------------------------------------------------------
P
A
L
L
R
R
P
S
--
L
V
A
L
N
K
V
D
L
L
E
------
E
E
----
A
V
K
A
L
A
D
A
L
A
R
E
G
L
A
------
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
A
L
V
R
S
T
P
-
P
P
E
M
P
K
P
V
P
-------------
Q
A
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
L
M
E
A
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
G
V
R
A
G
D
L
V
R
I
G
G
L
E
F
E
Y
I
P
EV
35
HHSearch
88.90
43%
-59
- C1 -
1UDX
3
OBG_THET8
A:
[1-414]
--
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
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G
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H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
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V
P
R
G
T
R
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F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
K
-
I
A
P
Y
P
F
T
T
L
S
P
N
L
--
G
V
V
E
V
S
E
E
--------------------
E
R
F
T
L
A
D
I
P
G
I
I
E
G
A
S
--
E
---
G
---
K
G
--
L
G
L
-
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
D
A
A
D
-------
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
D
---------------------------------------------------------
P
A
L
L
R
R
P
S
--
L
V
A
L
N
K
V
D
L
L
E
--
E
---
E
A
-----
V
K
A
L
A
D
A
L
A
------
R
E
G
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
A
L
V
R
S
T
P
-
P
P
E
M
P
K
P
V
-----
P
--------
Q
A
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
L
M
E
A
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
G
V
R
A
G
D
L
V
R
I
G
G
L
E
F
E
Y
I
P
--
2
PsiBlast_PDB
88.09
41%
-61
- C1 -
1UDX
3
OBG_THET8
A:
[1-413]
--
M
F
Q
D
V
L
V
I
T
V
A
A
G
R
G
G
D
G
A
V
S
F
R
R
E
K
F
V
P
K
G
G
P
D
G
G
D
G
G
R
G
G
S
V
Y
L
R
A
R
G
S
V
D
S
L
S
R
L
S
-
K
R
T
Y
K
A
E
D
G
E
H
G
R
G
S
Q
Q
H
G
R
G
G
E
D
L
V
I
E
V
P
R
G
T
R
V
F
D
A
D
T
G
E
L
L
A
D
L
T
E
E
G
Q
T
V
L
V
A
R
G
G
A
G
G
R
G
N
M
H
F
V
S
P
T
R
Q
A
P
R
F
A
E
A
G
E
E
G
E
K
R
R
L
R
L
E
L
M
L
I
A
D
V
G
L
V
G
Y
P
N
A
G
K
S
S
L
L
-----
A
A
M
T
R
A
H
P
K
-
I
A
P
Y
P
F
T
T
L
S
P
N
L
--
G
V
V
E
V
S
E
E
--------------------
E
R
F
T
L
A
D
I
P
G
I
I
E
G
A
S
--
E
---
G
---
K
G
--
L
G
L
-
E
F
L
----
R
H
I
A
R
T
R
V
L
L
Y
V
L
D
A
A
-------
D
E
P
L
K
T
L
E
T
L
R
K
E
V
G
A
Y
D
---------------------------------------------------------
P
A
L
L
R
R
P
S
--
L
V
A
L
N
K
V
D
L
L
E
------
E
E
----
A
V
K
A
L
A
D
A
L
A
------
R
E
G
L
A
V
L
P
V
S
A
L
T
G
A
G
L
P
A
L
K
E
A
L
H
A
L
V
R
S
T
P
-
P
P
E
M
P
K
P
V
P
----
Q
A
---------
G
V
E
V
V
P
V
A
E
G
V
Y
E
V
R
A
P
E
V
E
R
Y
L
A
R
I
K
G
D
L
M
E
A
A
G
Y
L
Q
E
V
F
R
R
Q
G
V
E
A
A
L
R
A
K
G
V
R
A
G
D
L
V
R
I
G
G
L
E
F
E
Y
I
P
--
36
HHSearch
86.44
71%
-71
- C1 -
1LNZ
2
OBG_BACSU
A:
[1-334]
--
M
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
K
-
I
A
D
Y
H
F
T
T
L
V
P
N
L
--
G
M
V
E
T
D
D
G
--------------------
R
S
F
V
M
A
D
L
P
G
L
I
E
G
A
H
--
Q
---
G
---
V
G
--
L
G
H
-
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
D
M
S
G
L
E
G
---
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
N
---------------------------------------------------------
L
R
L
T
E
R
P
Q
--
I
I
V
A
N
K
M
D
M
P
E
--
A
---
A
E
----
N
L
E
A
F
K
E
K
L
T
-------
D
D
Y
P
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
N
Q
L
E
N
T
P
-
E
F
P
L
Y
D
E
E
E
L
----------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.25
67%
-69
- C1 -
1LNZ
2
OBG_BACSU
A:
[2-342]
---
F
V
D
Q
V
K
V
Y
V
K
G
G
D
G
G
N
G
M
V
A
F
R
R
E
K
Y
V
P
K
G
G
P
A
G
G
D
G
G
K
G
G
D
V
V
F
E
V
D
E
G
L
R
T
L
M
D
F
R
Y
K
K
H
F
K
A
I
R
G
E
H
G
M
S
K
N
Q
H
G
R
N
A
D
D
M
V
I
K
V
P
P
G
T
V
V
T
D
D
D
T
K
Q
V
I
A
D
L
T
E
H
G
Q
R
A
V
I
A
R
G
G
R
G
G
R
G
N
S
R
F
A
T
P
A
N
P
A
P
Q
L
S
E
N
G
E
P
G
K
E
R
Y
I
V
L
E
L
K
V
L
A
D
V
G
L
V
G
F
P
S
V
G
K
S
T
L
L
-----
S
V
V
S
S
A
K
P
K
-
I
A
D
Y
H
F
T
T
L
V
P
N
L
--
G
M
V
E
T
D
D
G
--------------------
R
S
F
V
M
A
D
L
P
G
L
I
E
G
A
H
--
Q
---
G
---
V
G
--
L
G
H
-
Q
F
L
----
R
H
I
E
R
T
R
V
I
V
H
V
I
D
M
S
G
L
E
G
---
R
D
P
Y
D
D
Y
L
T
I
N
Q
E
L
S
E
Y
N
---------------------------------------------------------
L
R
L
T
E
R
P
Q
--
I
I
V
A
N
K
M
D
M
P
E
--
A
---
A
E
----
N
L
E
A
F
K
E
K
L
T
------
D
D
Y
P
-
V
F
P
I
S
A
V
T
R
E
G
L
R
E
L
L
F
E
V
A
N
Q
L
E
N
T
P
-
E
F
P
L
Y
D
E
E
E
L
----------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.84
28%
-92
- C1 -
2DYK
1
?
A:
[4-160]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
R
P
N
V
G
K
S
S
L
F
-----
N
R
L
L
K
K
R
S
-------------
D
L
K
E
G
V
V
E
T
D
R
G
---------------------
R
F
L
L
V
D
T
G
G
L
W
S
G
D
K
--
W
---
E
---
K
K
--
I
Q
E
-
K
V
D
----
R
A
L
E
D
A
E
V
V
L
F
A
V
D
G
R
A
-----------
E
L
T
Q
A
D
Y
E
V
A
E
Y
----------------------------------------------------------
L
R
R
K
G
K
P
V
--
I
L
V
A
T
K
V
D
D
P
K
--
H
---
E
L
----
Y
L
G
P
L
-------
Y
G
L
G
F
G
D
P
I
--
P
T
S
S
E
H
A
R
G
L
E
E
L
L
E
A
I
W
E
R
L
P
------------------------------------------------------------------------------------------------------
42
HHSearch
57.02
27%
-83
- C1 -
3IEV
2
ERA_AQUAE
A:
[11-185]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
-----
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
K
--
S
D
V
L
G
---
H
S
--
M
V
E
-
I
A
K
----
Q
S
L
E
E
A
D
V
I
L
F
M
I
D
A
T
E
------
G
W
R
P
R
D
E
E
I
Y
Q
N
F
I
K
--------------------------------------------------------------
P
L
N
K
P
V
--
I
V
V
I
N
K
I
D
K
I
G
--
P
---
A
K
----
N
V
L
P
L
I
D
E
I
H
K
K
---
H
P
E
L
T
E
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
-
P
L
F
P
E
D
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
E
L
I
L
G
R
--
8
PsiBlast_PDB
55.07
29%
-90
- C1 -
3R9W
6
ERA_AQUAE
A:
[12-189]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
-
A
G
----
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
K
--
S
---
D
---
V
---
L
G
H
-
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
D
--
A
T
E
G
---
W
R
P
R
D
E
E
I
Y
Q
N
------
F
---------------------------------------------------------
I
K
P
L
N
K
P
V
--
I
V
V
I
N
K
I
D
K
I
G
--
P
---
A
K
----
N
V
L
P
L
I
D
E
I
H
K
K
H
P
E
L
T
E
---
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
-
P
L
F
P
E
D
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
E
L
I
L
G
R
--
7
PsiBlast_PDB
54.82
29%
-86
- C1 -
3IEV
2
ERA_AQUAE
A:
[13-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
-
A
G
----
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
K
--
S
---
D
---
V
---
L
G
H
-
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
D
--
A
T
E
G
---
W
R
P
R
D
E
E
I
Y
Q
N
------
F
---------------------------------------------------------
I
K
P
L
N
K
P
V
--
I
V
V
I
N
K
I
D
K
I
G
--
P
---
A
K
----
N
V
L
P
L
I
D
E
I
H
K
K
H
P
E
L
T
E
---
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
-
P
L
F
P
E
D
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
E
L
I
L
G
R
--
9
PsiBlast_PDB
54.72
29%
-81
- C1 -
3R9X
4
ERA_AQUAE
A:
[12-189]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
-
A
G
----
T
T
R
M
R
V
L
--
G
V
K
N
I
P
N
E
--------------------
A
Q
I
I
F
L
D
T
P
G
I
Y
E
P
K
K
--
S
---
D
---
V
---
L
G
H
-
S
M
V
E
I
A
K
Q
S
L
E
E
A
D
V
I
L
F
M
I
D
--
A
T
E
G
---
W
R
P
R
D
E
E
I
Y
Q
N
------
F
---------------------------------------------------------
I
K
P
L
N
K
P
V
--
I
V
V
I
N
K
I
D
K
I
G
--
P
---
A
K
----
N
V
L
P
L
I
D
E
I
H
K
K
H
P
E
L
T
E
---
I
V
P
I
S
A
L
K
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
E
-
P
L
F
P
E
D
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
M
M
L
T
R
E
E
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
P
N
M
L
V
I
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
G
K
K
G
Q
R
L
K
E
I
G
K
R
A
R
Q
E
L
E
L
I
L
G
R
--
13
PsiBlast_PDB
53.74
26%
-66
- C1 -
2QU8
1
?
A:
[32-218]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
L
S
G
A
P
N
V
G
K
S
S
F
M
-----
N
I
V
S
R
A
N
V
D
-
V
Q
S
Y
-----
N
L
Y
V
--
G
H
F
D
H
K
L
---------------------
N
K
Y
Q
I
I
D
T
P
G
L
L
D
R
A
F
--
E
---
N
RN
T
I
E
--
M
T
T
I
T
A
L
----
A
H
I
N
--
G
V
I
L
F
I
I
D
I
S
E
Q
C
G
LT
I
K
E
Q
I
N
L
F
Y
S
I
K
S
V
F
-----------------------------------------------------------------
N
K
S
I
--
V
I
G
F
N
K
I
D
K
C
N
SL
S
---
I
D
----
N
K
L
L
I
K
Q
I
L
----
D
N
V
K
N
P
I
K
F
S
S
F
S
T
L
T
G
V
G
V
E
Q
A
K
I
T
A
C
E
L
L
K
N
D
Q
A
E
S
I
L
L
D
Q
E
Q
L
L
N
T
K
L
-----------------------------------------------------------------------------------
17
PsiBlast_PDB
53.38
22%
-82
- C1 -
2WJI
3
FEOB_METJA
A:
[5-160]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
Y
-
I
G
-----
T
V
E
K
K
E
--
G
E
F
E
Y
-
N
G
--------------------
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
--
N
---
S
---
I
D
E
I
I
A
R
-
D
Y
I
----
I
N
-
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
----
R
N
L
Y
------------
L
T
---------------------------------------------------------
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
--
S
L
GI
E
I
----
D
V
D
K
L
E
K
I
L
G
V
K
---------
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
-----------------------------------------------------------------------------------------------------
41
HHSearch
52.62
31%
-63
- C1 -
2DBY
3
?
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
V
G
I
V
G
L
P
N
V
G
K
S
T
L
F
-----
N
A
L
T
R
A
N
A
L
-
A
A
N
Y
P
F
A
T
I
D
K
N
V
--
G
V
V
P
L
E
D
E
R
L
Y
A
L
Q
R
T
F
AKGE
R
V
P
P
V
V
P
T
H
V
E
F
V
D
I
A
G
L
V
K
G
A
H
--
K
---
G
---
E
G
--
L
G
N
-
Q
F
L
----
A
H
I
R
E
V
A
A
I
A
H
V
L
R
C
F
P
D
P
-------
L
E
D
A
E
V
V
E
T
E
L
L
L
A
D
L
A
T
L
E
R
R
L
E
R
L
R
K
E
A
R
A
D
RER
L
P
L
L
E
A
A
E
G
L
Y
V
H
L
Q
E
GKPARTFPPS
E
A
V
A
R
F
L
K
E
T
P
L
L
T
A
K
P
V
--
I
Y
V
A
N
V
A
E
E
D
L
--
P
---
D
G
RGN
P
Q
V
E
A
V
R
R
K
A
L
------
E
E
G
A
E
V
V
V
V
S
A
R
L
E
A
E
L
A
E
L
S
G
E
E
A
R
E
L
L
A
A
Y
-
G
L
Q
E
S
G
L
Q
R
L
A
R
A
G
Y
R
A
L
D
L
L
T
F
F
T
A
G
E
K
E
V
R
A
W
T
V
R
R
G
T
K
A
P
R
A
A
G
E
I
H
S
D
M
E
R
G
F
I
R
A
E
V
I
P
W
D
K
L
V
E
A
G
G
W
A
R
A
K
E
R
G
W
V
R
L
E
G
K
D
Y
E
V
Q
D
G
D
--
51
HHSearch
52.46
21%
-76
- C1 -
2WJG
1
FEOB_METJA
A:
[6-170]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
Y
-
I
G
N
W
P
G
V
T
V
E
K
K
E
--
G
E
F
E
Y
N
-
G
--------------------
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
--
N
S--
I
D
--
E
I
--
I
A
R
-
D
Y
I
-----
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
------
E
---
R
N
L
Y
L
T
L
Q
L
M
E
--------------------------------------------------------------
M
G
A
N
L
--
L
L
A
L
N
K
M
D
L
A
K
--
S
---
L
G
----
I
E
I
D
V
-
D
K
L
E
K
-----
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
K
----------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
51.25
22%
-86
- C1 -
2WJG
1
FEOB_METJA
A:
[9-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
Y
-
I
G
N
W
P
G
V
T
V
E
K
K
E
--
G
E
F
E
Y
-
N
G
--------------------
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
--
N
---
S
---
I
D
E
I
I
A
R
-
D
Y
I
----
I
N
-
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
----
R
N
L
Y
------------
L
T
---------------------------------------------------------
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
--
S
L
GI
E
I
----
D
V
D
K
L
E
K
I
L
G
V
K
---------
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
K
----------------------------------------------------------------------------------------------------
59
Fugue
50.82
20%
-78
- C1 -
1EGA
3
ERA_ECOLI
A:
[4-182]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
S
Y
C
G
F
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
-----
N
K
L
L
G
Q
K
I
S
-
I
T
S
R
K
A
Q
T
T
R
H
R
I
--
V
G
I
H
T
E
G
A
--------------------
Y
Q
A
I
Y
V
D
T
P
G
L
H
M
E
E
K
--
R
---
A
---
I
N
R
L
M
N
K
-
A
A
S
----
S
S
I
G
D
V
E
L
V
I
F
V
V
E
G
T
R
W
-------------
T
P
D
D
E
M
V
L
N
K
---------------------------------------------------------
L
R
E
G
K
A
P
V
--
I
L
A
V
N
K
V
D
N
V
Q
--
E
---
K
A
----
D
L
L
P
H
L
Q
F
L
A
S
Q
M
N
----
F
L
D
I
V
P
I
S
A
E
T
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
T
-
H
H
F
P
E
D
Y
I
T
D
R
S
Q
R
F
M
A
S
E
I
I
R
E
K
L
M
R
F
L
G
A
E
L
P
Y
S
V
T
V
E
I
E
R
F
V
S
N
E
R
G
G
Y
D
I
N
G
L
I
L
V
E
R
E
G
Q
K
K
M
V
I
G
N
K
G
A
K
I
K
T
I
G
I
E
A
R
K
D
M
Q
E
M
F
E
A
P
V
--
60
Fugue
50.80
15%
-75
- C1 -
1PUI
4
ENGB_ECOLI
A:
[11-198]
------------------------------------------------------------------------------------------------------------------------------------------------
F
V
M
S
A
P
D
I
R
H
L
P
S
D
T
G
I
E
V
A
F
A
G
R
S
N
A
G
K
S
S
A
L
-----
N
T
L
T
N
Q
Q
L
-----
I
N
L
F
E
V
A
D
G
---------------------------------
K
R
L
V
D
L
P
G
Y
G
E
M
K
R
--
K
---
W
---
Q
R
--
A
L
G
-
E
Y
L
----
E
K
R
Q
S
L
Q
G
L
V
V
L
M
D
I
R
H
P
-------
L
K
D
L
D
Q
Q
M
I
E
W
A
V
D
S
N
---------------------------------------------------------
I
-----
A
V
--
L
V
L
L
T
K
A
D
K
L
---
A
---
S
G
----
A
R
K
A
Q
L
N
M
V
R
E
A
V
L
A
F
N
G
D
V
Q
V
E
T
F
S
S
L
K
K
Q
G
V
D
K
L
R
Q
K
L
D
T
W
F
S
------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.50
22%
-86
- C1 -
2WJH
3
FEOB_METJA
A:
[5-160]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
-----
N
A
L
T
G
E
N
V
Y
-
I
G
N
W
P
G
V
T
V
E
K
K
E
--
G
E
F
E
Y
-
N
G
--------------------
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
--
N
---
S
---
I
D
E
I
I
A
R
-
D
Y
I
----
I
N
-
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
----
R
N
L
Y
------------
L
T
---------------------------------------------------------
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
--
S
L
G
I
E
I
----
D
V
D
K
L
E
K
I
L
G
V
K
---------
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
L
----------------------------------------------------------------------------------------------------
48
HHSearch
50.48
21%
-81
- C1 -
1EGA
3
ERA_ECOLI
A:
[8-178]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
F
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
-----
N
K
L
L
G
Q
K
I
S
I
T
S
R
K
A
Q
T
T
R
H
R
I
V
--
G
I
H
T
E
-
G
A
--------------------
Y
Q
A
I
Y
V
D
T
P
G
L
H
M
E
E
K
--
R
A
I
-
N
---
R
L
--
M
N
K
-
A
A
S
----
S
S
I
G
D
V
E
L
V
I
F
V
V
E
G
T
R
W
--------
T
P
D
D
E
M
V
L
N
K
L
R
E
--------------------------------------------------------------
G
K
A
P
V
--
I
L
A
V
N
K
V
D
N
V
Q
--
E
---
K
A
----
D
L
L
P
H
L
Q
F
L
A
S
Q
----
M
N
F
L
D
I
V
P
I
S
A
E
T
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
T
-
H
H
F
P
E
D
Y
I
T
D
R
S
Q
R
F
M
A
S
E
I
I
R
E
K
L
M
R
F
L
G
A
E
L
P
Y
S
V
T
V
E
I
E
R
F
V
S
N
E
R
G
G
Y
D
I
N
G
L
I
L
V
E
R
E
G
Q
K
K
M
V
I
G
N
K
G
A
K
I
K
T
I
G
I
E
A
R
K
D
M
Q
E
M
F
E
A
P
V
--
47
HHSearch
50.41
20%
-78
- C1 -
3B1V
3
?
A:
[3-165]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
-----
N
L
I
T
G
H
N
Q
R
-
V
G
N
W
P
G
V
T
V
E
R
K
S
--
G
L
V
K
--
K
N
--------------------
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
YS
P
---
E
---
A
K
--
V
A
R
-
D
Y
L
-----
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
------
L
E
R
---
N
L
Y
L
T
T
Q
L
I
E
--------------------------------------------------------------
T
G
I
P
V
--
T
I
A
L
N
M
I
D
V
L
D
--
G
---
Q
G
----
K
K
I
N
-
V
D
K
L
S
Y
-----
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
-
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
--