@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1567: (2015-12-09 )
MRYTNGNFEAFARPRKPEGVDKKSAYIVGSGLAGLAAAVFLIRDGQMDGQRIHIFEELPLSGGSLDGVKRPDIGFVTRGGREMENHFECMWDMYRSIPSLEVPDASYLDEFYWLDKDDPNSSNCRLIHKQGNRLESDGDFTLGTHSKELVKLVMETEESLGAKTIEEVFSKEFFESNFWTYWATMFAFEKWHSAIEMRRYAMRFIHHIGGLPDFTSLKFNKYNQYDSMVKPIISYLESHNVDVQFDSKVTNISVDFKNGQKLAKAIHLTVGGEAKTIDLTPDDFVFVTNGSITESTNYGSHDTVAKPNTDLGGSWNLWENLAAQSDEFGHPKVFYKDIPKESWFVSATATIKDPAIEPYIERLTHRDLHDGKVNTGGIVTVTDSNWMMSFAIHRQPHFKEQKENETIVWIYGLYSNVEGNYIKKPIEECTGREITEEWLYHLGVPEMKIHDLSDKQYVSTVPVYMPYITSYFMPRVKGDRPDVIPQGSVNLAFIGNFAESPSRDTVFTTEYSIRTAMEAVYTFLNIERGVPEVFNSAFDIRVLLQSLYYLNDKKSVEDMDLPIPALMRKVGMKKIRGTYLEELLREAHLL
Atome Classification :
(20 SA)
--------------.........10........20....-------------------------....30........40........50........60........70.----------------------.......80----.....---.----.--..90........100-.-..-...-------.110....-....120--.......130........-140.-.....-..150.---.---.---..---------..160.......170...-----.----..-.-180.---...------.-..-190.....-..200------...----....210.-----------.-.......220.......230.......-240.......250.......260.......270.......280.......290.......300.---......310..--.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.---......480.......490.......500.......510.......520.......530.......540.......550.......560..-.....570.......580..---------.....590---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MRYTNGN
F
E
AFARPRKPEGVDKK
S
A
-------------------------
Y
I
VGS
G
L
A
G
L
A
A
A
V
F
L
I
RDGQMDG
Q
R
I
H
I
F
E
ELPLSGGSLDGVKRPD----------------------I
G
F
VTRGG-----
R
E
M
E
N
---
H
----
F
--
E
C
M
W
D
M
Y
RSIPSLEV-P-
D
A
-
S
Y
L
-------
D
E
-
F
Y
WLD-KDDPNSS--N
C
R
L
I
HKQG-NRLESDG
D
-
F
-TL-GT
H
S
K
-
E
L
V
K
L
V
---
M
---
E
---
T
E
---------
E
SL
G
A
K
T
I
E
E
V
F
S
K
E
F
F
E-----S----N
F
-
W
-
T
Y
W
A
---
T
M
F
------
A
-
F
E
-
K
W
H
S
A
I
E
M
-
R
R
Y
A
M
------
R
F
I
----
H
H
IGG--L-----------P-DFTS
L
K
FNKY
N
Q
Y
D
S
M
V
K
P
I
I
S
Y
L
E
SH-N
V
D
V
Q
FDSKV
T
N
I
S
V
D
FKN
G
Q
K
L
A
K
A
I
H
L
T
VGG
E
A
K
T
I
DLTPD
D
F
V
F
VTNGSITESTNYGSHDT---VAKPNTDLGGS--
W
N
L
W
E
N
L
AAQSDEFGHP
K
V
F
Y
KDIPKE
S
W
F
V
S
A
T
A
TIKDPA
I
E
P
Y
I
E
R
L
T
HRDLHDGKVNTG
G
I
V
T
V
TDSN
W
M
M
S
F
A
IHRQPHF
K
E
QKEN
E
T
I
V
W
I
Y
G
L
YSNVEG
N
Y
I
K
K
P
I
E
E
CTG
R
E
I
T
E
E
W
L
Y
HLGVP
E
M
K
I
HDLSDK
Q
Y
V
S
TV
P
V
Y
M
P
Y
I
T
S
Y
F
M---PRVKGDRPDVIPQG
S
V
N
L
A
F
I
GNFAESPSR
D
T
V
F
T
T
E
Y
S
I
R
T
A
M
E
A
V
Y
T
F
L
N
IERG
V
P
E
V
F
N
SA
F
D
I
R
V
L
L
Q
S
L
Y
YLNDKKSVEDMDL
P
I
P
-
A
L
M
R
K
V
G
M
K
K
I
R
G
T
Y
L
E
E
L
L
---------
R
EAHLL-----------
2
PsiBlast_PDB
95.90
64%
-95
- C2 -
4IA5
6
?
A:
[3-591]
----------------
Y
S
N
G
N
Y
E
A
F
A
D
P
K
K
P
A
G
V
D
K
K
S
A
-------------------------
Y
I
I
G
S
G
L
A
G
L
S
T
A
V
F
L
V
R
D
A
Q
M
K
G
E
N
I
H
I
L
E
E
L
P
V
------------------------------------
F
V
V
R
G
G
-----
R
E
M
E
N
---
H
----
F
--
E
C
L
W
D
M
Y
R
S
I
P
S
L
E
V
-
P
-
G
A
-
S
Y
L
-------
D
E
-
Y
Y
W
L
D
-
K
E
D
P
N
S
S
--
N
C
R
L
I
Y
N
R
G
-
D
R
L
P
S
D
G
Q
-
Y
-
G
L
-
G
K
C
A
N
-
E
I
V
K
L
I
---
M
---
T
---
P
E
---------
K
E
I
E
G
Q
T
I
E
E
F
F
S
D
E
F
F
K
-----
T
----
N
F
-
W
-
T
Y
W
S
---
T
M
F
------
A
-
F
E
-
K
W
H
S
L
A
E
M
-
R
R
Y
A
M
------
R
F
I
----
H
H
I
D
G
--
L
-----------
P
-
D
F
T
A
L
K
F
N
K
Y
N
Q
Y
E
S
M
V
K
P
L
L
A
Y
L
K
D
H
-
G
V
Q
F
E
Y
D
C
H
V
K
N
V
E
V
D
H
E
G
D
S
K
I
A
K
K
I
V
M
T
Q
N
G
K
D
K
E
I
D
L
T
H
N
D
I
V
F
V
T
N
G
S
I
T
E
S
S
T
Y
G
D
Q
N
T
---
P
A
P
I
T
N
A
K
G
D
S
--
W
K
L
W
E
N
L
A
K
Q
D
P
A
F
G
H
P
D
V
F
C
E
N
L
P
E
R
S
W
F
V
S
A
T
A
T
L
E
N
K
K
L
A
P
Y
F
E
R
L
T
K
R
S
L
Y
D
G
K
V
N
T
G
G
I
I
T
I
V
D
S
N
W
E
L
S
F
T
I
H
R
Q
P
H
F
K
S
Q
N
P
D
Q
I
V
V
W
I
Y
A
L
Y
S
D
T
E
G
N
Y
I
K
K
R
I
V
D
C
T
G
K
E
I
A
E
E
L
L
Y
H
L
G
V
P
E
S
Q
I
S
E
L
A
S
E
E
N
M
N
T
V
P
V
Y
M
P
Y
I
T
S
Y
F
M
---
P
R
R
D
G
D
R
P
D
V
V
P
E
G
S
I
N
L
A
F
I
G
N
F
A
E
S
P
T
R
D
T
V
F
T
T
E
Y
S
V
R
T
A
M
E
A
V
Y
T
L
L
N
V
D
R
G
V
P
E
V
F
D
S
I
Y
D
I
R
Q
L
L
R
A
M
Y
Y
M
S
D
K
K
K
L
A
D
Q
D
M
P
L
P
E
K
L
A
V
K
T
G
M
R
K
I
K
K
T
W
V
E
E
L
L
---------
K
E
A
N
L
V
-----------
37
Fugue
95.38
66%
-90
- C2 -
4IA6
21
?
A:
[1-591]
--------------
M
Y
Y
S
N
G
N
Y
E
A
F
A
D
P
K
K
P
A
G
V
D
K
K
S
A
-------------------------
Y
I
I
G
S
G
L
A
G
L
S
T
A
V
F
L
V
R
D
A
Q
M
K
G
E
N
I
H
I
L
E
E
L
P
V
A
G
----------------------------------
F
V
V
R
G
G
-----
R
E
M
E
N
---
H
----
F
--
E
C
L
W
D
M
Y
R
S
I
P
S
L
E
V
-
P
-
G
A
-
S
Y
L
-------
D
E
-
Y
Y
W
L
D
-
K
E
D
P
N
S
S
--
N
C
R
L
I
Y
N
R
G
-
D
R
L
P
S
D
G
Q
-
Y
-
G
L
-
G
K
C
A
N
-
E
I
V
K
L
I
---
M
---
T
---
P
E
---------
K
E
I
E
G
Q
T
I
E
E
F
F
S
D
E
F
F
K
-----
T
----
N
F
-
W
-
T
Y
W
S
---
T
M
F
------
A
-
F
E
-
K
W
H
S
L
A
E
M
-
R
R
Y
A
M
------
R
F
I
----
H
H
I
D
G
--
L
-----------
P
-
D
F
T
A
L
K
F
N
K
Y
N
Q
Y
E
S
M
V
K
P
L
L
A
Y
L
K
D
H
-
G
V
Q
F
E
Y
D
C
H
V
K
N
V
E
V
D
H
E
G
D
S
K
I
A
K
K
I
V
M
T
Q
N
G
K
D
K
E
I
D
L
T
H
N
D
I
V
F
V
T
N
G
S
I
T
E
S
S
T
Y
G
D
Q
N
T
---
P
A
P
I
T
N
A
K
G
D
S
--
W
K
L
W
E
N
L
A
K
Q
D
P
A
F
G
H
P
D
V
F
C
E
N
L
P
E
R
S
W
F
V
S
A
T
A
T
L
E
N
K
K
L
A
P
Y
F
E
R
L
T
K
R
S
L
Y
D
G
K
V
N
T
G
G
I
I
T
I
V
D
S
N
W
E
L
S
F
T
I
H
R
Q
P
H
F
K
S
Q
N
P
D
Q
I
V
V
W
I
Y
A
L
Y
S
D
T
E
G
N
Y
I
K
K
R
I
V
D
C
T
G
K
E
I
A
E
E
L
L
Y
H
L
G
V
P
E
S
Q
I
S
E
L
A
S
E
E
N
M
N
T
V
P
V
Y
M
P
Y
I
T
S
Y
F
M
---
P
R
R
D
G
D
R
P
D
V
V
P
E
G
S
I
N
L
A
F
I
G
N
F
A
E
S
P
T
R
D
T
V
F
T
T
E
Y
S
V
R
T
A
M
E
A
V
Y
T
L
L
N
V
D
R
G
V
P
E
V
F
D
S
I
Y
D
I
R
Q
L
L
R
A
M
Y
Y
M
S
D
K
K
K
L
A
D
Q
D
M
P
L
P
E
K
L
A
V
K
T
G
M
R
K
I
K
K
T
W
V
E
E
L
L
---------
K
E
A
N
L
V
-----------
1
PsiBlast_PDB
95.38
66%
-90
- C2 -
4IA6
21
?
A:
[1-591]
--------------
M
Y
Y
S
N
G
N
Y
E
A
F
A
D
P
K
K
P
A
G
V
D
K
K
S
A
-------------------------
Y
I
I
G
S
G
L
A
G
L
S
T
A
V
F
L
V
R
D
A
Q
M
K
G
E
N
I
H
I
L
E
E
L
P
V
A
G
----------------------------------
F
V
V
R
G
G
-----
R
E
M
E
N
---
H
----
F
--
E
C
L
W
D
M
Y
R
S
I
P
S
L
E
V
-
P
-
G
A
-
S
Y
L
-------
D
E
-
Y
Y
W
L
D
-
K
E
D
P
N
S
S
--
N
C
R
L
I
Y
N
R
G
-
D
R
L
P
S
D
G
Q
-
Y
-
G
L
-
G
K
C
A
N
-
E
I
V
K
L
I
---
M
---
T
---
P
E
---------
K
E
I
E
G
Q
T
I
E
E
F
F
S
D
E
F
F
K
-----
T
----
N
F
-
W
-
T
Y
W
S
---
T
M
F
------
A
-
F
E
-
K
W
H
S
L
A
E
M
-
R
R
Y
A
M
------
R
F
I
----
H
H
I
D
G
--
L
-----------
P
-
D
F
T
A
L
K
F
N
K
Y
N
Q
Y
E
S
M
V
K
P
L
L
A
Y
L
K
D
H
-
G
V
Q
F
E
Y
D
C
H
V
K
N
V
E
V
D
H
E
G
D
S
K
I
A
K
K
I
V
M
T
Q
N
G
K
D
K
E
I
D
L
T
H
N
D
I
V
F
V
T
N
G
S
I
T
E
S
S
T
Y
G
D
Q
N
T
---
P
A
P
I
T
N
A
K
G
D
S
--
W
K
L
W
E
N
L
A
K
Q
D
P
A
F
G
H
P
D
V
F
C
E
N
L
P
E
R
S
W
F
V
S
A
T
A
T
L
E
N
K
K
L
A
P
Y
F
E
R
L
T
K
R
S
L
Y
D
G
K
V
N
T
G
G
I
I
T
I
V
D
S
N
W
E
L
S
F
T
I
H
R
Q
P
H
F
K
S
Q
N
P
D
Q
I
V
V
W
I
Y
A
L
Y
S
D
T
E
G
N
Y
I
K
K
R
I
V
D
C
T
G
K
E
I
A
E
E
L
L
Y
H
L
G
V
P
E
S
Q
I
S
E
L
A
S
E
E
N
M
N
T
V
P
V
Y
M
P
Y
I
T
S
Y
F
M
---
P
R
R
D
G
D
R
P
D
V
V
P
E
G
S
I
N
L
A
F
I
G
N
F
A
E
S
P
T
R
D
T
V
F
T
T
E
Y
S
V
R
T
A
M
E
A
V
Y
T
L
L
N
V
D
R
G
V
P
E
V
F
D
S
I
Y
D
I
R
Q
L
L
R
A
M
Y
Y
M
S
D
K
K
K
L
A
D
Q
D
M
P
L
P
E
K
L
A
V
K
T
G
M
R
K
I
K
K
T
W
V
E
E
L
L
---------
K
E
A
N
L
V
-----------
11
PsiBlast_CBE
95.01
66%
-90
- C2 -
4IA6
15
?
B:
[1-591]
--------------
M
Y
Y
S
N
G
N
Y
E
A
F
A
D
P
K
K
P
A
G
V
D
K
K
S
A
-------------------------
Y
I
I
G
S
G
L
A
G
L
S
T
A
V
F
L
V
R
D
A
Q
M
K
G
E
N
I
H
I
L
E
E
L
P
--------------------------------------
V
V
R
G
G
-----
R
E
M
E
N
---
H
----
F
--
E
C
L
W
D
M
Y
R
S
I
P
S
L
E
V
-
P
-
G
A
-
S
Y
L
-------
D
E
-
Y
Y
W
L
D
-
K
E
D
P
N
S
S
--
N
C
R
L
I
Y
N
R
G
-
D
R
L
P
S
D
G
Q
-
Y
-
G
L
-
G
K
C
A
N
-
E
I
V
K
L
I
---
M
---
T
---
P
E
---------
K
E
I
E
G
Q
T
I
E
E
F
F
S
D
E
F
F
K
-----
T
----
N
F
-
W
-
T
Y
W
S
---
T
M
F
------
A
-
F
E
-
K
W
H
S
L
A
E
M
-
R
R
Y
A
M
------
R
F
I
----
H
H
I
D
G
--
L
-----------
P
-
D
F
T
A
L
K
F
N
K
Y
N
Q
Y
E
S
M
V
K
P
L
L
A
Y
L
K
D
H
-
G
V
Q
F
E
Y
D
C
H
V
K
N
V
E
V
D
H
E
G
D
S
K
I
A
K
K
I
V
M
T
Q
N
G
K
D
K
E
I
D
L
T
H
N
D
I
V
F
V
T
N
G
S
I
T
E
S
S
T
Y
G
D
Q
N
T
---
P
A
P
I
T
N
A
K
G
D
S
--
W
K
L
W
E
N
L
A
K
Q
D
P
A
F
G
H
P
D
V
F
C
E
N
L
P
E
R
S
W
F
V
S
A
T
A
T
L
E
N
K
K
L
A
P
Y
F
E
R
L
T
K
R
S
L
Y
D
G
K
V
N
T
G
G
I
I
T
I
V
D
S
N
W
E
L
S
F
T
I
H
R
Q
P
H
F
K
S
Q
N
P
D
Q
I
V
V
W
I
Y
A
L
Y
S
D
T
E
G
N
Y
I
K
K
R
I
V
D
C
T
G
K
E
I
A
E
E
L
L
Y
H
L
G
V
P
E
S
Q
I
S
E
L
A
S
E
E
N
M
N
T
V
P
V
Y
M
P
Y
I
T
S
Y
F
M
---
P
R
R
D
G
D
R
P
D
V
V
P
E
G
S
I
N
L
A
F
I
G
N
F
A
E
S
P
T
R
D
T
V
F
T
T
E
Y
S
V
R
T
A
M
E
A
V
Y
T
L
L
N
V
D
R
G
V
P
E
V
F
D
S
I
Y
D
I
R
Q
L
L
R
A
M
Y
Y
M
S
D
K
K
K
--
D
Q
---------------
K
I
K
K
T
W
V
E
E
L
L
---------
K
E
A
N
L
V
-----------
12
PsiBlast_CBE
79.77
42%
-82
- C2 -
4UIR
2
OLHYD_ELIME
B:
[58-616]
-------------------------------
Q
S
Y
D
N
S
K
I
-------------------------
Y
I
I
G
S
G
I
A
G
M
S
A
A
Y
Y
F
I
R
D
G
H
V
P
A
K
N
I
T
F
L
E
Q
L
H
I
D
G
G
S
L
D
G
A
G
N
P
T
----------------------
D
G
Y
I
I
R
--------
E
M
D
M
---
T
----
Y
--
E
N
L
W
D
M
F
Q
D
I
P
A
L
E
M
-
P
-
A
P
Y
S
V
L
-------
D
E
-
Y
R
L
I
N
-
D
N
D
S
N
Y
S
--
K
A
R
L
I
N
N
K
G
--
E
I
K
D
F
S
K
-
F
-
G
L
-
N
K
M
D
Q
L
A
I
I
R
L
L
---
L
---
K
---
N
K
---------
E
E
L
D
D
L
T
I
E
D
Y
F
S
E
S
F
L
K
-----
S
----
N
F
-
W
-
T
F
W
R
---
T
M
F
------
A
-
F
E
-
N
W
H
S
L
L
E
L
-
K
L
Y
M
H
------
R
F
L
----
H
A
I
D
G
--
L
-----------
N
-
D
L
S
S
L
V
F
P
K
Y
N
Q
Y
D
T
F
V
T
P
L
R
K
F
L
Q
E
K
-
G
V
N
I
H
L
N
T
L
V
K
D
L
D
I
H
I
N
T
E
G
K
V
V
E
G
I
I
T
E
Q
D
G
K
E
V
K
I
P
V
G
K
N
D
Y
V
I
V
T
T
G
S
M
T
E
D
T
F
Y
G
N
N
K
T
API
I
G
I
D
N
S
T
S
G
Q
S
A
G
W
K
L
W
K
N
L
A
A
K
S
E
I
F
G
K
P
E
K
F
C
S
N
I
E
K
S
A
W
-
E
S
A
T
L
T
C
K
P
S
A
L
I
D
K
L
K
E
Y
S
V
N
D
P
Y
S
G
K
T
V
T
G
G
I
I
T
I
T
D
S
N
W
L
M
S
F
T
C
N
R
Q
P
H
F
P
E
Q
P
D
D
V
L
V
L
W
V
Y
A
L
F
M
D
K
E
G
N
Y
I
K
K
T
M
L
E
C
T
G
D
E
I
L
A
E
L
C
Y
H
L
G
I
-
E
D
Q
L
E
N
V
Q
K
N
T
I
V
R
T
--
A
F
M
P
Y
I
T
S
M
F
M
---
P
R
A
K
G
D
R
P
R
V
V
P
E
G
C
K
N
L
G
L
V
G
Q
F
V
E
T
-
N
N
D
V
V
F
T
M
E
S
S
V
R
T
A
R
I
A
V
Y
K
L
L
N
L
N
K
Q
V
P
D
I
N
P
L
Q
Y
D
I
R
H
L
L
K
A
A
K
T
L
N
D
D
K
P
F
V
G
-----
E
-
G
L
L
R
K
V
----
L
K
G
T
Y
F
E
H
V
L
---------
P
A
G
A
A
E
-----------
3
PsiBlast_PDB
79.40
42%
-81
- C2 -
4UIR
3
OLHYD_ELIME
A:
[58-616]
-------------------------------
Q
S
Y
D
N
S
K
I
-------------------------
Y
I
I
G
S
G
I
A
G
M
S
A
A
Y
Y
F
I
R
D
G
H
V
P
A
K
N
I
T
F
L
E
Q
L
H
I
D
G
G
S
L
D
G
A
G
N
P
T
----------------------
D
G
Y
I
I
R
G
G
-----
R
E
M
D
M
---
T
----
Y
--
E
N
L
W
D
M
F
Q
D
I
P
A
L
E
M
-
P
-
A
P
Y
S
V
L
-------
D
E
-
Y
R
L
I
N
-
D
N
D
S
N
Y
S
--
K
A
R
L
I
N
N
K
G
--
E
I
K
D
F
S
K
-
F
-
G
L
-
N
K
M
D
Q
L
A
I
I
R
L
L
---
L
---
K
---
N
K
---------
E
E
L
D
D
L
T
I
E
D
Y
F
S
E
S
F
L
K
-----
S
----
N
F
-
W
-
T
F
W
R
---
T
M
F
------
A
-
F
E
-
N
W
H
S
L
L
E
L
-
K
L
Y
M
H
------
R
F
L
----
H
A
I
D
G
--
L
-----------
N
-
D
L
S
S
L
V
F
P
K
Y
N
Q
Y
D
T
F
V
T
P
L
R
K
F
L
Q
E
K
-
G
V
N
I
H
L
N
T
L
V
K
D
L
D
I
H
I
N
T
E
G
K
V
V
E
G
I
I
T
E
Q
D
G
K
E
V
K
I
P
V
G
K
N
D
Y
V
I
V
T
T
G
S
M
T
E
D
T
F
Y
G
N
N
K
T
API
I
G
I
D
N
S
T
S
G
Q
S
A
G
W
K
L
W
K
N
L
A
A
K
S
E
I
F
G
K
P
E
K
F
C
S
N
I
E
K
S
A
W
-
E
S
A
T
L
T
C
K
P
S
A
L
I
D
K
L
K
E
Y
S
V
N
D
P
Y
S
G
K
T
V
T
G
G
I
I
T
I
T
D
S
N
W
L
M
S
F
T
C
N
R
Q
P
H
F
P
E
Q
P
D
D
V
L
V
L
W
V
Y
A
L
F
M
D
K
E
G
N
Y
I
K
K
T
M
L
E
C
T
G
D
E
I
L
A
E
L
C
Y
H
L
G
I
-
E
D
Q
L
E
N
V
Q
K
N
T
I
V
R
T
--
A
F
M
P
Y
I
T
S
M
F
M
---
P
R
A
K
G
D
R
P
R
V
V
P
E
G
C
K
N
L
G
L
V
G
Q
F
V
E
T
-
N
N
D
V
V
F
T
M
E
S
S
V
R
T
A
R
I
A
V
Y
K
L
L
N
L
N
K
Q
V
P
D
I
N
P
L
Q
Y
D
I
R
H
L
L
K
A
A
K
T
L
N
D
D
K
P
F
V
G
-----
E
-
G
L
L
R
K
V
----
L
K
G
T
Y
F
E
H
V
L
---------
P
A
G
E
E
H
-----------
38
Fugue
78.86
42%
-79
- C2 -
4UIR
3
OLHYD_ELIME
A:
[2-646]
NPITSKF
D
K
V
L
N
A
S
S
E
Y
G
H
V
N
H
E
P
D
S
S
K
E
Q
Q
R
N
T
P
Q
K
S
M
PFSDQIGNYQR
N
K
G
I
P
VQSYDN
S
K
I
Y
I
I
G
S
G
I
A
G
M
S
A
A
Y
Y
F
I
R
D
G
H
V
P
A
K
N
I
T
F
L
E
Q
L
H
I
D
G
G
S
L
D
G
A
G
N
P
T
----------------------
D
G
Y
I
I
R
G
G
-----
R
E
M
D
M
---
T
----
Y
--
E
N
L
W
D
M
F
Q
D
I
P
A
L
E
M
-
P
-
A
P
Y
S
V
L
-------
D
E
-
Y
R
L
I
N
-
D
N
D
S
N
Y
S
--
K
A
R
L
I
N
N
K
G
--
E
I
K
D
F
S
K
-
F
-
G
L
N
K
M
D
Q
L
-
A
I
I
R
L
L
---
L
---
K
---
N
K
---------
E
E
L
D
D
L
T
I
E
D
Y
F
S
E
S
F
L
K
-----
S
----
N
F
-
W
-
T
F
W
R
---
T
M
F
------
A
-
F
E
-
N
W
H
S
L
L
E
L
-
K
L
Y
M
H
------
R
F
L
----
H
A
I
D
G
--
L
-----------
N
-
D
L
S
S
L
V
F
P
K
Y
N
Q
Y
D
T
F
V
T
P
L
R
K
F
L
Q
E
K
-
G
V
N
I
H
L
N
T
L
V
K
D
L
D
I
H
I
N
T
E
G
K
V
V
E
G
I
I
T
E
Q
D
G
K
E
V
K
I
P
V
G
K
N
D
Y
V
I
V
T
T
G
S
M
T
E
D
T
F
Y
G
N
N
K
T
API
I
G
I
D
N
S
T
S
G
Q
S
A
G
W
K
L
W
K
N
L
A
A
K
S
E
I
F
G
K
P
E
K
F
C
S
N
I
E
K
S
A
W
-
E
S
A
T
L
T
C
K
P
S
A
L
I
D
K
L
K
E
Y
S
V
N
D
P
Y
S
G
K
T
V
T
G
G
I
I
T
I
T
D
S
N
W
L
M
S
F
T
C
N
R
Q
P
H
F
P
E
Q
P
D
D
V
L
V
L
W
V
Y
A
L
F
M
D
K
E
G
N
Y
I
K
K
T
M
L
E
C
T
G
D
E
I
L
A
E
L
C
Y
H
L
G
I
-
E
D
Q
L
E
N
V
Q
K
N
T
I
V
R
T
A
--
F
M
P
Y
I
T
S
M
F
M
---
P
R
A
K
G
D
R
P
R
V
V
P
E
G
C
K
N
L
G
L
V
G
Q
F
V
E
-
T
N
N
D
V
V
F
T
M
E
S
S
V
R
T
A
R
I
A
V
Y
K
L
L
N
L
N
K
Q
V
P
D
I
N
P
L
Q
Y
D
I
R
H
L
L
K
A
A
K
T
L
N
D
D
K
---------
P
-
F
V
G
E
G
L
L
R
K
V
L
K
G
T
Y
F
E
H
V
L
PAGEEHESF
I
A
E
H
V
N
K
F
R
E
W
V
K
G
IRG
43
Fugue
40.70
14%
-39
- C2 -
1GOS
1
AOFB_HUMAN
A:
[4-500]
-----------------------------------
K
C
D
V
-------------------------
V
V
V
G
G
G
I
S
G
M
A
A
A
K
L
L
H
D
S
G
L
----
N
V
V
V
L
E
A
R
D
R
V
G
G
R
T
Y
T
L
R
N
Q
K
----------------------
V
K
Y
V
D
L
G
G
-----
S
Y
V
G
P
---
T
----
Q
--
N
R
I
L
R
L
A
K
E
L
G
--------------------------
L
E
-
T
Y
K
V
N
E
V
--
E
R
L
I
H
H
V
K
G
-
K
S
Y
P
F
R
G
P
-
F
P
P
V
-
W
N
P
I
T
-
Y
L
D
H
N
N
---
F
---
W
---
R
T
---------
M
D
D
M
G
R
E
I
P
S
D
A
P
W
K
A
P
L
-----
A
----
E
E
-
W
-
D
N
M
T
---
M
K
E
------
L
-
L
D
-
K
L
C
W
T
E
S
A
-
K
Q
L
A
T
------
L
F
V
----
N
L
C
V
T
AE
T
-----------
H
-
E
V
S
A
L
W
F
L
W
Y
V
K
Q
C
G
G
T
T
R
I
I
S
T
-
T
N
G
-
G
Q
E
R
K
F
V
G
G
S
G
Q
V
S
E
R
I
M
D
L
--
L
G
D
R
V
K
L
--
E
R
P
V
I
Y
I
D
Q
T
R
E
N
V
L
V
E
T
L
N
H
E
M
Y
E
A
K
Y
V
I
S
A
I
---
P
P
T
L
G
M
K
I
H
F
N
--
P
P
L
P
M
M
R
N
Q
M
I
T
R
V
P
L
G
S
V
I
K
C
I
V
Y
Y
K
E
P
F
W
R
K
K
-------------------------
D
Y
C
G
T
M
I
I
D
G
E
E
A
P
V
A
Y
T
L
D
D
T
K
------
P
E
G
N
Y
A
A
I
M
G
F
I
L
A
H
K
A
R
K
L
A
R
L
T
K
E
E
R
L
K
K
L
C
E
L
Y
A
K
V
L
G
S
L
E
A
L
E
P
V
H
Y
E
E
K
N
W
C
E
E
Q
Y
S
G
G
C
Y
T
T
Y
F
P
---
P
G
I
L
T
Q
Y
G
R
V
L
R
Q
P
V
D
R
I
Y
F
A
G
T
E
T
A
T
H
W
S
G
Y
M
E
G
A
V
E
A
G
E
R
A
A
R
E
I
L
H
A
M
G
K
I
P
E
D
E
I
W
Q
S
E
P
E
S
V
D
V
P
A
Q
P
I
----
T
T
T
F
L
E
R
H
L
P
S
V
P
-
G
L
L
R
L
I
G
L
T
T
------------------------------------
8
PsiBlast_PDB
39.76
31%
-113
- C2 -
4PAA
1
M2GD_RAT
A:
[19-62]
-------------------------------
E
W
K
D
R
A
E
T
-------------------------
V
I
I
G
G
G
C
V
G
V
S
L
A
Y
H
L
A
K
A
G
M
R
D
---
V
V
L
L
E
K
S
E
L
T
A
G
S
T
W
H
A
A
G
L
T
----------------------
T
Y
F
H
P
G
I
N
-----
L
K
K
I
H
---
Y
----
D
--
S
I
K
L
Y
E
R
L
E
E
E
T
G
Q
V
-
V
-
G
F
-
H
Q
P
-------
G
S
-
I
R
L
A
T
-
T
P
E
R
V
D
E
--
F
K
Y
Q
M
T
R
T
N
-
W
H
A
T
E
Q
Y
I
-
I
-
E
P
-
E
K
I
H
E
-
L
F
P
L
L
N
---
M
---
D
---
K
I
---------
L
A
G
L
Y
N
P
G
D
G
H
I
D
P
Y
S
L
T
-----
M
----
A
L
-
A
-
T
G
A
R
---
K
Y
G
------
A
-
L
L
-
K
Y
P
A
P
V
T
S
-
L
K
P
R
P
------
D
G
T
----
W
D
V
E
T
--
P
-----------
Q
-
G
S
V
R
A
N
R
I
V
N
A
A
G
F
W
A
R
E
V
G
K
M
I
G
L
D
H
-
P
L
I
P
V
Q
H
Q
Y
V
I
T
S
T
I
P
E
V
K
A
L
K
R
E
L
P
V
L
R
D
L
E
G
S
Y
Y
L
R
Q
E
R
D
G
L
L
F
G
P
Y
E
S
Q
E
K
M
K
L
Q
A
S
W
V
A
H
---
G
V
P
P
G
F
G
K
E
L
F
--
E
S
D
L
D
R
I
T
E
H
V
E
A
A
M
E
M
V
P
V
L
K
K
A
D
I
I
N
I
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
V
G
P
H
Q
G
V
R
N
Y
W
V
A
I
G
F
G
Y
G
I
I
H
A
G
G
V
G
T
Y
L
S
D
W
I
L
H
G
E
P
P
F
D
L
I
E
L
D
P
N
R
Y
G
K
W
T
T
T
Q
Y
T
E
A
K
A
R
E
S
Y
G
F
N
N
I
V
G
Y
P
K
E
E
R
F
A
G
R
P
T
Q
R
V
S
G
L
Y
K
I
L
E
S
K
C
S
M
G
F
H
A
G
W
E
Q
P
H
W
F
Y
---
K
P
G
Q
D
T
Q
Y
R
P
S
F
R
R
T
N
W
F
E
P
V
G
S
E
Y
K
Q
V
M
Q
R
V
G
V
I
D
L
S
P
F
G
K
F
N
I
K
G
Q
D
S
T
Q
L
L
D
H
L
C
A
N
V
I
P
K
V
G
F
T
N
I
S
H
M
L
T
P
R
G
R
V
Y
A
E
L
T
V
S
H
Q
S
P
-
G
E
F
L
L
I
T
G
S
G
S
E
L
H
D
L
R
W
I
E
---------
E
A
A
V
R
G
-----------
9
PsiBlast_PDB
39.53
31%
-119
- C2 -
4PAB
1
M2GD_RAT
A:
[40-83]
-------------------------------
E
W
K
D
R
A
E
T
-------------------------
V
I
I
G
G
G
C
V
G
V
S
L
A
Y
H
L
A
K
A
G
M
R
D
---
V
V
L
L
E
K
S
E
L
T
A
G
S
T
W
H
A
A
G
L
T
----------------------
T
Y
F
H
P
G
I
N
-----
L
K
K
I
H
---
Y
----
D
--
S
I
K
L
Y
E
R
L
E
E
E
T
G
Q
V
-
V
-
G
F
-
H
Q
P
-------
G
S
-
I
R
L
A
T
-
T
P
E
R
V
D
E
--
F
K
Y
Q
M
T
R
T
N
-
W
H
A
T
E
Q
Y
I
-
I
-
E
P
-
E
K
I
H
E
-
L
F
P
L
L
N
---
M
---
D
---
K
I
---------
L
A
G
L
Y
N
P
G
D
G
H
I
D
P
Y
S
L
T
-----
M
----
A
L
-
A
-
T
G
A
R
---
K
Y
G
------
V
-
L
L
-
K
Y
P
A
P
V
T
S
-
L
K
P
R
P
------
D
G
T
----
W
D
V
E
T
--
P
-----------
Q
-
G
S
V
R
A
N
R
I
V
N
A
A
G
F
W
A
R
E
V
G
K
M
I
G
L
D
H
-
P
L
I
P
V
Q
H
Q
Y
V
V
T
S
T
I
P
E
V
K
A
L
K
R
E
L
P
V
L
R
D
L
E
G
S
Y
Y
L
R
Q
E
R
D
G
L
L
F
G
P
Y
E
S
Q
E
K
M
K
L
Q
A
S
W
V
A
H
---
G
V
P
P
G
F
G
K
E
L
F
--
E
S
D
L
D
R
I
T
E
H
V
E
A
A
M
E
M
V
P
V
L
K
K
A
D
I
I
N
I
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
V
G
P
H
Q
G
V
R
N
Y
W
V
A
I
G
F
G
Y
G
I
I
H
A
G
G
V
G
K
Y
L
S
D
W
I
L
H
G
E
P
P
F
D
L
I
E
L
D
P
N
R
Y
G
K
W
T
T
T
Q
Y
T
E
A
K
A
R
E
S
Y
G
F
N
N
I
V
G
Y
P
K
E
E
R
F
A
G
R
P
T
Q
R
V
S
G
L
Y
K
I
L
E
S
K
C
S
M
G
F
H
A
G
W
E
Q
P
H
W
F
Y
---
K
P
G
Q
D
T
Q
Y
R
P
S
F
R
R
T
N
W
F
R
P
V
G
S
E
Y
K
Q
V
M
Q
R
V
G
V
I
D
L
S
P
F
G
K
F
N
I
K
G
Q
D
S
T
Q
L
L
D
H
L
C
A
N
V
I
P
K
V
G
F
T
N
I
S
H
M
L
T
P
R
G
R
V
Y
A
E
L
T
V
S
H
Q
S
P
-
G
E
F
L
L
I
T
G
S
G
S
E
L
H
D
L
R
W
I
E
---------
E
A
A
V
R
G
-----------
44
Fugue
36.88
15%
-68
- C2 -
2I0Z
2
?
A:
[25-444]
----------------------------------
M
H
Y
D
V
-------------------------
I
V
I
G
G
G
P
S
G
L
M
A
A
I
G
A
A
E
E
G
A
----
N
V
L
L
L
-------------------------------------------------------------------------------------------------------------
D
K
G
N
K
L
--
G
R
K
L
A
I
S
G
G
-
G
R
C
----
N
-
V
-
T
N
-
R
L
P
L
D
-
E
I
V
K
H
I
-----------------------
P
G
N
G
R
F
L
Y
S
A
F
S
I
-----------------
F
-
N
N
E
D
---
I
I
T
------
F
-
F
E
-
N
L
G
V
K
L
K
E
-
E
D
H
G
R
------
M
F
P
----
V
S
-----------------------------
N
K
A
Q
S
V
V
D
A
L
L
T
R
L
K
D
L
-
G
V
K
I
R
T
N
T
P
V
E
T
I
E
Y
E
----
N
G
Q
T
K
A
V
I
L
Q
T
G
E
-----
V
L
E
T
N
H
V
V
I
A
V
G
G
K
S
V
P
Q
T
G
S
T
---------------
G
D
G
--
Y
A
W
A
E
K
A
G
H
T
I
T
E
L
F
P
T
E
V
P
I
L
-
S
N
E
P
F
I
R
D
R
S
L
Q
G
L
A
L
R
D
I
N
L
S
V
L
N
A
I
I
S
H
K
M
D
M
L
F
T
H
F
G
L
S
----
G
P
A
A
L
R
C
S
Q
F
V
V
K
A
L
K
K
F
K
T
N
T
I
Q
M
S
I
D
-
A
L
P
E
E
N
S
E
Q
L
F
Q
R
M
L
K
Q
M
K
E
D
-------------------
P
K
K
G
I
K
N
V
L
K
G
Y
V
P
E
R
Y
F
L
F
L
---
L
E
K
N
E
I
D
G
S
E
-
Q
A
G
Q
V
S
H
E
K
I
R
A
L
V
K
D
F
K
E
F
T
V
N
V
N
G
T
Q
S
I
E
K
A
F
V
T
G
G
G
V
S
V
K
E
I
N
P
K
E
M
S
S
K
-----
F
T
N
G
L
Y
F
C
G
-----
E
V
L
D
I
H
G
Y
-----------
T
G
G
Y
N
I
T
S
A
L
---------
V
T
G
R
I
A
G
T
T
A
G
E
N
A
K--
7
PsiBlast_PDB
36.81
31%
-106
- C2 -
4P9S
1
M2GD_RAT
A:
[19-62]
-------------------------------
E
W
K
D
R
A
E
T
-------------------------
V
I
I
G
G
G
C
V
G
V
S
L
A
Y
H
L
A
K
A
G
M
R
D
---
V
V
L
L
E
K
S
E
L
T
A
G
S
T
W
H
A
A
G
L
T
----------------------
T
Y
F
H
P
G
I
N
-----
L
K
K
I
H
---
Y
----
D
--
S
I
K
L
Y
E
R
L
E
E
E
T
G
Q
V
-
V
-
G
F
-
H
Q
P
-------
G
S
-
I
R
L
A
T
-
T
P
E
R
V
D
E
--
F
K
Y
Q
M
T
R
T
N
-
W
H
A
T
E
Q
Y
I
-
I
-
E
P
-
E
K
I
H
E
-
L
F
P
L
L
N
---
M
---
D
---
K
I
---------
L
A
G
L
Y
N
P
G
D
G
H
I
D
P
Y
S
L
T
-----
M
----
A
L
-
A
-
T
G
A
R
---
K
Y
G
------
A
-
L
L
-
K
Y
P
A
P
V
T
S
-
L
K
P
R
P
------
D
G
T
----
W
D
V
E
T
--
P
-----------
Q
-
G
S
V
R
A
N
R
I
V
N
A
A
G
F
W
A
R
E
V
G
K
M
I
G
L
D
H
-
P
L
I
P
V
Q
H
Q
Y
V
I
T
S
T
I
P
E
V
K
A
L
K
R
E
L
P
V
L
R
D
L
E
G
S
Y
Y
L
R
Q
E
R
D
G
L
L
F
G
P
Y
E
S
Q
E
K
M
K
L
Q
A
S
W
V
A
H
---
G
V
P
P
G
F
G
K
E
L
F
--
E
S
D
L
D
R
I
T
E
H
V
E
A
A
M
E
M
V
P
V
L
K
K
A
D
I
I
N
I
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
V
G
P
H
Q
G
V
R
N
Y
W
V
A
I
G
F
G
Y
G
I
I
H
A
G
G
V
G
T
Y
L
S
D
W
I
L
H
G
E
P
P
F
D
L
I
E
L
D
P
N
R
Y
G
K
W
T
T
T
Q
Y
T
E
A
K
A
R
E
S
Y
G
F
N
N
I
V
G
Y
P
K
E
E
R
F
A
G
R
P
T
Q
R
V
S
G
L
Y
K
I
L
E
S
K
C
S
M
G
F
H
A
G
W
E
Q
P
H
W
F
Y
---
K
P
G
Q
D
T
Q
Y
R
P
S
F
R
R
T
N
W
F
E
P
V
G
S
E
Y
K
Q
V
M
Q
R
V
G
V
I
D
L
S
P
F
G
K
F
N
I
K
G
Q
D
S
T
Q
L
L
D
H
L
C
A
N
V
I
P
K
V
G
F
T
N
I
S
H
M
L
T
P
R
G
R
V
Y
A
E
L
T
V
S
H
Q
S
P
-
G
E
F
L
L
I
T
G
S
G
S
E
L
H
D
L
R
W
I
E
---------
E
A
A
V
R
G
-----------
45
Fugue
33.17
12%
-48
- C2 -
1H83
3
PAO_MAIZE
A:
[5-463]
------------------------------------
P
R
V
-------------------------
I
V
V
G
A
G
M
S
G
I
S
A
A
K
R
L
S
E
A
G
I
---
T
D
L
L
I
L
E
A
T
D
H
I
G
G
R
M
H
K
T
N
F
A
------------------------
G
I
N
V
E
L
G
ANWVE
G
V
N
G
G
---
K
----
M
--
N
P
I
W
P
I
V
N
S
T
L
K
L
R
N
-
F
-
R
S
-
D
F
D
-------
Y
L
-
A
Q
N
V
Y
-
K
E
D
G
G
V
Y
--
D
E
D
Y
V
Q
----
K
R
I
E
------------
L
A
D
-
S
V
E
E
M
G
---
E
---
K
---
L
S
---------
A
T
L
H
--------
A
S
G
R
D
D
-----
M
----
S
I
-
L
-
A
M
Q
R
---
L
N
E
------
H
-
Q
P
-
N
G
P
A
T
P
V
D
-
M
V
V
D
Y
------
Y
K
F
----
D
Y
E
F
A
--
E
-----------
P
P
R
V
T
S
L
Q
N
T
V
P
L
A
T
F
S
D
F
G
D
D
V
Y
F
V
A
D
Q
-
R
G
Y
E
A
V
V
Y
Y
L
A
G
Q
Y
L
K
T
D
D
K
S
G
K
I
V
D
P
R
L
Q
L
N
K
V
V
R
E
I
K
Y
S
P
G
G
V
T
V
K
T
E
D
----
N
S
V
Y
S
A
D
Y
V
---
M
V
S
A
S
L
G
V
L
Q
S
--
D
L
I
---------------
Q
F
K
P
K
L
P
--
T
W
K
V
R
A
I
Y
Q
F
D
M
A
V
Y
T
K
I
F
L
K
F
P
R
K
F
W
P
E
G
K
G
R
E
F
F
L
Y
A
S
S
R
R
G
Y
Y
G
V
W
Q
E
F
E
K
Q
Y
P
-
D
A
------
N
V
L
L
V
T
V
T
D
E
E
S
R
R
I
E
Q
Q
S
D
E
Q
T
K
A
E
I
M
Q
V
L
R
K
M
F
P
G
K
D
V
P
D
A
T
----
D
I
L
V
P
R
W
W
S
D
R
F
Y
K
G
T
F
S
N
W
P
V
G
V
N
R
Y
E
Y
D
Q
L
R
A
P
V
G
R
V
Y
F
T
G
E
H
T
S
E
H
Y
N
G
Y
V
H
G
A
Y
L
S
G
I
D
S
A
E
I
L
I
N
C
A
Q
K
K
M
C
----------------------------------------------------------------------------------
40
Fugue
32.82
11%
-42
- C2 -
2BA9
4
?
A:
[2-424]
-------------------------------
S
I
S
K
D
S
R
I
-------------------------
A
I
I
G
A
G
P
A
G
L
A
A
G
M
Y
L
E
Q
A
G
F
---
H
D
Y
T
I
L
E
R
T
D
H
V
G
G
K
C
H
S
P
N
Y
H
G
----------------------
R
R
-
Y
E
M
G
A
-----
I
M
G
V
P
---
S
----
Y
--
D
T
I
Q
E
I
M
D
R
T
G
D
K
V
D
-
G
-
P
K
-
L
R
R
-------
E
F
-
L
H
E
D
G
-
E
I
Y
V
P
E
K
--
D
P
V
R
G
P
Q
V
M
-
A
A
V
Q
K
L
G
Q
-
L
-
L
A
-
T
K
Y
Q
G
-
Y
D
A
N
G
H
---
Y
---
N
---
K
V
---------
H
E
D
L
M
L
P
F
D
E
F
L
A
L
N
G
C
E
-----
A
----
A
R
-
D
-
L
W
I
N
---
P
F
T
------
A
-
F
-----
G
Y
G
H
F
-
D
N
V
P
A
------
A
Y
V
----
L
K
Y
L
D
--
F
-----------
V
-
T
M
M
S
F
A
K
G
D
L
W
T
W
A
D
G
T
Q
A
M
F
E
H
L
N
A
T
L
E
H
P
A
E
R
N
V
D
I
T
R
I
T
R
E
-------
D
G
K
V
H
I
H
T
T
D
W
D
R
E
S
D
-----
V
L
V
L
T
V
P
--------------------------------
L
E
K
F
L
D
Y
S
D
A
D
D
D
E
R
E
Y
F
S
K
I
I
H
Q
Q
Y
M
V
D
A
C
L
V
K
E
Y
P
T
I
S
G
Y
V
P
D
N
M
R
P
E
R
L
G
H
V
M
V
Y
Y
H
R
W
A
D
D
P
H
Q
I
I
T
T
Y
L
L
R
N
H
P
D
Y
A
D
K
T
Q
E
E
C
R
Q
M
V
L
D
D
M
E
T
F
G
H
P
---------
V
E
K
I
I
E
E
Q
T
W
Y
Y
F
P
H
V
S
S
E
D
Y
K
A
G
W
Y
E
K
V
E
G
M
---------------------------
Q
G
R
R
N
T
F
Y
A
G
E
I
M
S
F
G
N
------
F
D
E
V
C
H
Y
S
K
D
L
V
T
R
F
F
V
--------------------------------------------------------------------------------------
17
HHSearch
32.03
16%
-65
- C2 -
3NRN
1
?
A:
[1-249]
------------------------------------
M
R
A
-------------------------
V
V
V
G
A
G
L
G
G
L
L
A
G
A
F
L
A
R
N
G
----
H
E
I
I
V
L
E
K
S
A
M
I
G
G
R
F
T
N
L
P
--
Y
----------------------
K
G
F
Q
L
S
T
G
-----
A
L
H
M
I
PHG
E
----
D
--
G
P
L
A
H
L
L
R
I
L
G
A
K
V
E
-
I
--
V
-
N
S
N
-------
P
K
-
G
K
I
L
W
-
E
-
G
K
I
-----
F
H
--
Y
--
R
-
E
S
W
------
K
-
F
L
-
S
--------
K
L
L
---
A
---
E
I
R
M
N
K
---------
L
P
K
E
E
I
P
A
D
E
W
I
K
E
K
I
G
E
N
E
F
L
L
S
----
V
L
-
E
-
S
F
A
G
---
W
A
D
------
S
V
S
L
-
S
D
L
T
A
L
E
L
-
A
K
E
I
R
------
A
A
L
----
R
---------------------
W
G
G
P
G
L
I
R
G
G
C
-
K
A
V
I
D
E
L
E
R
I
I
M
E
N
-
K
G
K
I
L
T
R
K
E
V
V
E
I
N
I
E
E
K
----
K
---
V
Y
T
R
-
D
--
N
E
E
Y
---
S
F
D
V
A
I
S
N
V
G
V
R
E
T
V
K
L
I
G
R
D
Y
F
---
D
R
D
Y
L
K
Q
V
D
S
I
--
E
P
S
E
G
I
K
F
N
L
A
V
P
G
E
P
R
I
G
N
T
I
V
F
T
P
G
L
M
I
N
G
F
N
E
P
S
A
L
D
K
S
L
A
R
E
G
Y
T
L
I
M
A
H
M
A
L
K
N
G
N
V
K
K
A
I
E
K
G
W
E
E
L
L
E
I
F
P
E
G
E
P
L
L
A
Q
V
Y
H
I
E
W
P
L
N
E
V
L
V
V
G
D
G
Y
R
P
P
G
G
I
E
V
D
G
I
A
L
G
V
M
K
A
L
E
K
L
N
L
G
S
F
S
E
W
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
30.72
13%
-58
- C2 -
3KA7
1
?
A:
[1-257]
------------------------------------
M
K
T
-------------------------
V
V
I
G
A
G
L
G
G
L
L
S
A
A
R
L
S
K
A
G
----
H
E
V
E
V
F
E
R
L
P
I
T
G
G
R
F
T
N
L
S
--
Y
----------------------
K
G
F
Q
L
S
S
G
-----
A
F
H
M
L
P--
N
----
G
PG
G
P
L
A
C
F
L
K
E
V
E
A
S
V
N
-
I
--
V
-
R
-
S
-------
E
M
T
T
V
R
V
P
L
K
K
G
N
P
D
Y
--
V
K
G
F
--
K
D
--
I
S
F
N
D
F
P
S
---
L
L
-
S
Y
K
D
R
M
K
I
A
L
L
I
---
V
S
--
T
---
R
K
---------
N
R
P
S
G
S
S
L
Q
A
W
I
K
S
Q
V
S
D
-----
E
W
L
I
-
K
F
-
A
D
S
F
C
G
---
W
A
L
------
S
L
K
S
-
D
E
V
P
V
E
E
V
-
F
E
I
I
E
------
N
M
Y
----
R
---------------------
F
G
G
T
G
I
P
E
G
G
C
-
K
G
I
I
D
A
L
E
T
V
I
S
A
N
-
G
G
K
I
H
T
G
Q
E
V
S
K
I
L
I
E
N
G
----
K
A
A
G
I
I
A
D
----
D
R
I
H
---
D
A
D
L
V
I
S
N
L
G
H
A
A
T
A
V
L
C
S
E
A
L
S
---
K
E
A
D
A
A
Y
F
K
M
V
--
G
T
L
Q
P
S
A
G
I
K
I
C
L
A
A
D
E
P
L
V
G
H
T
G
V
L
L
T
P
Y
T
R
R
I
N
G
V
N
E
V
T
Q
A
D
P
E
L
A
P
P
G
K
H
L
T
M
C
H
Q
Y
V
A
P
E
N
V
K
N
L
E
S
E
I
E
M
G
L
E
D
L
K
E
I
F
P
G
K
R
Y
E
V
L
L
I
Q
S
Y
H
D
E
W
P
V
N
R
A
A
S
G
T
D
P
G
N
E
T
P
F
S
G
L
Y
V
V
G
D
G
A
K
G
K
G
G
I
E
V
E
G
V
A
L
G
V
M
S
V
M
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
28.64
13%
-65
* C2 *
3NKS
2
PPOX_HUMAN
A:
[2-295]
-----------------------------------
G
R
T
V
-------------------------
V
V
L
G
G
G
I
S
G
L
A
A
S
Y
H
L
S
R
A
P
--
C
P
P
K
V
V
L
V
E
S
S
E
R
L
G
G
W
I
R
S
V
R
G
-
P
----------------------
N
G
A
I
F
E
L
G
-----
P
R
G
I
R
---
P
AG
A
L
G
--
A
R
T
L
L
L
V
S
E
L
G
L
D
S
E
-
V
--
L
-
P
V
R
GDHPAAQ
N
R
-
F
L
Y
V
---
G
G
A
L
-----
H
A
----
L
P
-
T
G
L
R
G
--
P
S
P
-
P
F
-
S
K
P
L
F
W
A
G
L
R
E
L
---
T
---
K
---
P
R
---------
G
K
E
P
D
E
T
V
H
S
F
A
Q
R
R
L
G
P
E
V
A
--
S
----
L
A
M
D
-
S
L
C
R
---
G
V
F
A-----
G
-
N
S
-
R
E
L
S
I
R
S
C
F
P
S
L
F
Q
A
E
Q
T
HR
S
I
L
L
G
L
L
L
G
------QPDS
A
L
I
R
Q
A
L
A
-
E
R
W
S
Q
W
S
L
R
G
G
-
L
E
M
L
P
Q
A
L
E
T
H
L
T
S
R
-
G
V
S
V
L
R
G
Q
P
V
C
G
L
S
L
Q
A
E
G
---
R
W
-
K
V
S
L
R
----
D
S
S
L
---
E
A
D
H
V
I
S
A
I
P
A
S
V
L
S
E
L
L
P
A
E
A
A
---
P
L
A
R
A
L
S
A
I
T
A
--
V
S
V
A
V
V
N
L
Q
Y
Q
G
A
H
L
P
V
Q
G
F
G
H
L
V
P
S
S
E
D
P
G
V
L
G
I
V
Y
D
S
V
A
F
P
E
Q
D
G
S
P
P
G
L
R
V
T
V
M
L
G
G
S
W
L
Q
T
L
E
A
S
G
C
V
L
S
Q
E
L
F
Q
Q
R
A
Q
E
A
A
A
T
Q
L
G
L
K
E
M
P
S
H
C
L
V
H
L
H
K
N
C
I
P
Q
Y
T
L
G
H
W
Q
K
L
E
S
A
R
Q
F
L
T
A
H
R
L
P
L
T
L
A
G
A
S
Y
E
G
V
A
V
N
D
C
I
E
S
G
R
Q
A
A
V
S
V
---
L
G
T
E
--------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
26.38
11%
-50
- C2 -
3P1W
-
?
A:
[1-300]
--------------------------------
Q
G
E
H
Y
D
V
-------------------------
I
I
L
G
T
G
L
K
E
C
I
L
S
G
L
L
S
H
Y
G
----
K
K
I
L
V
L
D
R
N
P
Y
Y
G
G
E
T
A
S
L
N
L
T
N
L
Y
N
T
FKPKENIPSKYGEN----
R
H
W
N
V
D
L
I
-----
P
K
F
I
L
---
V
----
G
--
G
N
L
V
K
I
L
K
K
T
R
V
T
N
Y
L
E
-
W
L
-
V
-
V
-------
E
G
-
S
Y
V
Y
Q
-
H
Q
K
K
G
F
L
TS
E
K
F
I
-
H
K
V
P
A
T
D
M
E
A
L
V
S
-
P
-
L
L
-
S
L
M
E
K
N
R
C
K
N
F
Y
Q
Y
V
S
---
E
---
W
D
ANKRNTWDN
L
D
P
Y
K
L
T
M
L
E
I
Y
K
H
F
N
L
C
-----
Q
L
T
I
D
F
L
-
G
-
H
A
V
A
---
L
Y
L
------
N
-
D
D
Y
L
K
Q
P
A
Y
L
T
-
L
E
R
I
K
------
L
Y
M
----
Q
S
I
S
A
--
F
-------------
G
K
S
P
F
I
Y
P
L
Y
G
L
-
G
G
I
P
E
G
F
S
R
M
C
A
I
N
---
T
F
M
L
N
K
N
V
V
D
F
V
F
D
D
D
N
---
K
V
C
G
I
K
S
S
-
D
--
G
E
I
A
---
Y
C
D
K
V
I
C
D
P
S
Y
V
M
H
L
K
N
K
I
K
K
I
G
---
Q
V
I
R
C
I
C
I
L
S
N
--
P
I
P
E
T
N
Q
T
N
S
C
Q
I
I
I
P
Q
N
Q
L
N
R
K
S
D
I
Y
I
N
L
V
S
F
Q
H
G
V
T
L
K
G
K
Y
I
A
I
V
S
A
T
V
E
T
N
N
P
I
K
E
I
E
K
P
L
E
L
L
G
T
I
E
E
K
F
V
K
I
S
D
L
Y
V
S
T
S
K
K
P
A
D
N
I
F
V
T
S
S
Y
D
A
T
S
H
F
E
T
A
T
N
D
L
L
Q
I
W
E
N
L
W
G
Q
K
L
N
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
26.06
9%
-56
- C2 -
2BCG
2
GDI1_YEAST
G:
[7-298]
-------------------------------
T
I
D
T
D
Y
D
V
-------------------------
I
V
L
G
T
G
I
T
E
C
I
L
S
G
L
L
S
V
D
G
----
K
K
V
L
H
I
D
K
Q
D
H
Y
G
G
E
A
A
S
V
T
L
S
Q
LYEKFKQNPISKEERESKFGKD
R
D
W
N
V
D
L
I
-----
P
K
F
L
M
---
A
----
N
--
G
E
L
T
N
I
L
I
H
T
D
V
T
R
Y
-
V
D
F
K
-
Q
-
V
-------
S
G
-
S
Y
V
F
K
-
Q
-
G
K
I
-----
Y
K
V
P
A
N
E
I
-
E
A
I
---
S
S
-
P
-
L
M
-
G
I
F
E
K
R
R
M
K
K
F
L
---
E
WIS
S
---
Y
K
EDDLSTHQG
L
D
L
D
K
N
T
M
D
E
V
Y
Y
K
F
G
L
G
-----
N
----
S
T
-
K
-
E
F
I
G
HAM
A
L
W
TNDDYL
Q
-
Q
P
-
A
R
P
S
F
E
R
I
-
L
L
Y
C
Q
------
S
V
A
--------
R
--
Y
-------------
G
K
S
P
Y
L
Y
P
M
Y
G
L
-
G
E
L
P
Q
G
F
A
R
L
S
A
I
Y
-
G
G
T
Y
M
L
D
T
P
I
D
E
V
L
Y
K
K
D
T
--
G
K
F
E
G
V
K
T
K
-
L
--
G
-
T
F
---
K
A
P
L
V
I
A
D
P
T
Y
F
P
E
K
C
K
S
T
G
Q
R
V
---
I
R
A
I
C
I
L
N
H
P
V
--
P
N
T
S
N
A
D
S
L
Q
I
I
I
P
Q
S
Q
L
G
R
K
S
D
I
Y
V
A
I
V
S
D
A
H
N
V
C
S
K
G
H
Y
L
A
I
I
S
T
I
I
E
T
D
K
P
H
I
E
L
E
P
A
F
K
L
L
G
P
I
E
E
K
F
M
G
I
A
E
L
F
E
P
R
E
D
G
S
K
D
N
I
Y
L
S
R
S
Y
D
A
S
S
H
F
E
S
M
T
D
D
V
K
D
I
Y
F
R
V
T
G
H
P
L
V
L
K
Q
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
25.11
25%
-73
- C2 -
1SEZ
1
PPOM_TOBAC
A:
[13-87]
-----------------------------------
A
K
R
V
-------------------------
A
V
I
G
A
G
V
S
G
L
A
A
A
Y
K
L
K
I
H
G
----
L
N
V
T
V
F
E
A
E
G
K
A
G
G
K
L
R
S
V
S
--
Q
----------------------
D
G
L
I
W
D
E
G
-----
A
N
T
M
T
E--
S
----
E
--
G
D
V
T
F
L
I
D
S
L
G
L
R
E
K
-
Q
-
Q
F
-
P
L
S
-------
Q
N
-
K
R
Y
I
A
-
R
N
G
T
P
V
L
--
L
P
S
N
P
I
D
L
I
-
K
S
N
F
L
S
T
G
-
S
-
K
L
-
Q
M
L
L
E
-
P
I
L
W
S
H
---
E
---
S
---
V
S
---------
G
F
F
Q
R
H
F
G
K
E
V
V
D
Y
L
I
D
P
-----
F
----
V
A
-
G
-
T
C
G
G
---
D
P
D
------
S
-
L
S
-
M
H
H
S
F
P
E
L
-
W
N
L
E
K
------
R
F
G
----
S
V
I
L
G
--
A
-----------
I
-
R
S
K
L
S
K
T
S
A
N
K
K
R
Q
R
G
S
F
S
F
L
G
G
M
Q
T
L
-
T
D
A
I
C
K
D
L
R
E
D
E
L
R
L
N
S
R
V
L
E
L
S
C
S
C
T
E
D
S
A
I
D
S
W
S
I
I
S
A
S
P
H
K
R
Q
S
E
E
E
S
F
D
A
V
I
M
T
A
P
L
C
D
V
---
K
S
M
K
I
A
K
R
G
N
P
--
F
L
L
N
F
I
P
E
V
D
Y
V
P
L
S
V
V
I
T
T
F
K
R
E
N
V
K
Y
P
L
E
G
F
G
V
L
V
P
S
K
E
Q
Q
H
G
L
K
T
L
G
T
L
F
S
S
M
M
F
P
D
R
A
P
N
N
V
Y
L
Y
T
T
F
V
G
G
S
R
N
R
E
L
A
K
A
S
R
T
E
L
K
E
I
V
T
S
D
L
K
Q
L
L
G
A
E
G
E
P
T
Y
V
N
H
L
Y
W
S
K
A
F
P
L
Y
G
H
N
Y
D
S
V
L
D
A
I
D
K
M
E
K
N
L
P
G
L
F
Y
A
G
N
H
R
G
G
L
S
V
G
K
A
L
---
S
S
G
C
N
A
A
D
L
V
I
S
Y
L
E
S
V
S
------------------------------------------------------------------------------------------------------------------------