@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1597: (2015-12-09 )
MKLAVLGTGMIVKEVLPVLQKIEGIDLVAILSTVRSLETAKDLAKEYNMSLATSEYKAVLDNEEIDTVYIGLPNHLHFDYAKEALLAGKHVICEKPFTLEASQLEELVSIANTRQLILLEAITNQYLPNFDLVKEHLSNLGDIKIVECNYSQYSSRYDAFKRGEIAPAFNPEMGGGALRDLNIYNLHLVIGLFGEPITAQYLPNIERGIDTSGVLVLDYGHFKTVCIGAKDCSAEVKSTIQGDKGSIAILGPTNTMPKISLTMNGQESHVYQLNGDRHRMHDEFVIFEGIISNLDFKRAAQALEHSRTVMKVLDMVTK
Atome Classification :
(20 SA)
-------------------------------.........-10..-.-.-....20-.-.--......30...-.....40........-50..----.------.....60........70........80........90........100.......110..-.-....120......----.130.....--.--.--140.......150.......160---........-170.......180.......190..----.--.-...200-.----...-.-------..--.210.......-220-.....--..--230....---..-----.----..240.......250.....----..-260..-----------.---.--------.-.--.---270--.----...-----...--..280.......290........300.......310......--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------
M
K
L
A
V
LG
T
G
-
M
I
V
K
-
E
-
V
-
L
P
V
L
Q
K-I-E--G
I
D
L
V
A
I
L
S
T
V
-
R
S
L
E
T
A
K
D
L
A
K
E
YNM-SLA
T
----
S
------
E
Y
K
A
V
LDNEEI
D
T
V
Y
IGLPNH
L
H
F
D
Y
A
K
E
A
L
L
AGK
H
V
ICEKPFTL
E
A
S
Q
L
E
E
L
V
S
I
ANT
R
-
Q
-
L
I
L
L
E
A
I
T
N
QYLP----
N
F
D
L
V
K
E
H
L
--S--N--LG
D
I
K
I
V
E
CN
Y
S
Q
Y
S
S
R
Y
D
A
FK----RGEIAPAF-NPEMGGG
A
L
R
D
L
N
I
Y
N
L
H
L
V
I
G
LFG----E--P-
I
T
A
Q
-
Y
-L----
P
N
I
-
E
-------RG--IDTS
G
V
L
V
L
DY-GH
F
-
K
T
V
C
I--GA--
K
--
D
C
S
A
---
E
V
-----
K
----
S
T
IQGDKG
S
I
A
I
LGPTNTM
P
----
K
I
-
S
L
T
MN-----------G---Q--------E-
S
--
H
---
V
----
Y
----
Q
LN-----GDR--HRMHD
E
F
V
I
F
E
G
I
I
-SNL
D
F
K
R
A
A
Q
A
L
E
H
S
R
T
V
M
K
V
L
D
M
VTK--------------------
1
PsiBlast_PDB
85.86
29%
-109
- C1 -
4NHE
5
?
A:
[5-313]
-------------------------------
L
K
L
G
V
I
G
T
G
-
A
I
S
H
-
H
-
F
-
I
E
A
A
H
T
-
S
-
G
--
E
Y
Q
L
V
A
I
Y
S
---
R
K
L
E
T
A
A
T
F
A
S
R
Y
Q
--
N
I
Q
L
----
F
------
D
Q
L
E
V
F
F
K
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
-
N
-
C
F
I
F
E
A
A
R
N
Y
H
E
K
----
A
F
T
T
I
K
N
F
L
--
A
--
D
---
K
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
----
A
G
Q
T
P
N
V
F
-
S
D
R
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
----
K
--
A
-
N
D
A
T
-
Y
H
A
----
Q
Q
L
-
D
-------
N
S
--
I
D
L
N
G
D
G
I
L
F
Y
-
P
D
Y
-
Q
V
H
I
K
--
A
G
--
K
--
N
I
T
S
---
N
L
-----
P
----
C
E
I
Y
T
T
D
G
T
L
T
L
----
N
T
I
E
----
H
I
R
S
A
I
F
T
-----------
D
---
H
--------
Q
-
G
--
N
---
Q
----
V
----
Q
L
P
-----
I
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
-
Q
Q
P
D
L
N
L
Y
Q
T
W
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
--------------------
78
Fugue
73.64
21%
-87
* C1 *
2O4U
9
DHDH_MACFA
X:
[2-332]
------------------------------A
L
R
W
G
I
V
S
V
G
-
L
I
S
S
-
D
-
F
-
T
A
V
L
Q
T
-
L
-
P
--
R
S
E
H
Q
V
V
A
V
A
A
-
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
-
P
K
A
Y
----
G
------
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
----
A
S
E
A
L
R
S
V
L
--
A
QG
T
--
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
P
R
A
V
-------------
D
W
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ--
K
--
P
-
E
K
I
S
-
V
-
M
----
G
R
R
H
E
-------
T
G
--
V
D
D
T
V
T
V
L
L
Q
Y
P
G
E
V
-
H
G
S
F
T
--
C
S
--
I
--
T
A
Q
L
---
S
N
-----
T
----
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
C
W
C
P
T
----
E
L
-
V
V
K
G
E
-----------
H
---
K
--------
E
-
F
--
L
---
L
----
P
----
P
V
P
KNCNF
D
N
G
--
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
-
R
K
G
L
K
E
S
P
V
I
P
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
AIGVTFPQD-----------
87
HHSearch
73.47
22%
-91
- C1 -
3OHS
10
DHDH_MACFA
X:
[3-323]
-------------------------------
L
R
W
G
I
V
S
V
G
-
L
I
S
S
-
D
-
F
-
T
A
V
L
Q
T
-
L
-
P
RS
E
H
Q
V
V
A
V
A
A
R
---
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
-
P
K
A
Y
----
G
------
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
----
A
S
E
A
L
R
S
V
L
--
A
QG
T
--
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
V
------------
P
R
A
V
-
D
W
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
----
G
QK
P
-
E
K
I
S
-
V
-
M
----
G
R
R
-
H
E------
T
G
--
V
D
D
T
V
T
V
L
L
Q
Y
-
P
G
E
V
H
G
S
F
T
--
C
S
--
I
--
T
A
Q
L
---
S
N
-----
T
----
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
C
W
C
P
T
----
E
L
-
V
V
K
G
E
-----------
H
---
K
--------
E
-
F
LL
P
PVP
K
----
N
----
C
N
F
-----
D
N
G
--
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
-
R
K
G
L
K
E
S
P
V
I
P
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
--------------------
95
HHSearch
73.00
22%
-97
- C1 -
3KUX
1
?
A:
[8-338]
-------------------------------
I
K
V
G
L
L
G
Y
G
-
Y
A
S
K
-
T
F
H
-
A
P
L
I
M
G
-
T
-
P
--
G
L
E
L
A
G
V
S
S
S
---
D
A
S
K
V
H
A
---
D
W
P
A
-
I
P
V
V
----
S
------
D
P
Q
M
L
F
N
D
P
S
I
D
L
I
V
I
P
T
P
N
D
T
H
F
P
L
A
Q
S
A
L
A
A
G
K
H
V
V
V
D
K
P
F
T
V
T
L
S
Q
A
N
A
L
K
E
H
A
D
D
A
-
G
-
L
L
L
S
V
F
H
N
R
R
W
D
S
----
D
F
L
T
L
K
T
L
L
--
A
E
G
S
--
L
G
N
V
V
Y
F
E
S
H
F
D
R
Y
R
P
E
I
-----------
R
Q
R
W
R
E
Q
---
G
G
G
I
W
Y
D
L
G
P
H
L
L
D
Q
A
L
Q
L
F
G
----
L
--
P
-
E
T
L
N
-
V
-
D
----
L
G
M
-
L
RPG----
S
Q
--
S
V
D
Y
F
H
A
V
L
S
Y
-
P
G
Q
-
R
V
V
L
H
--
S
T
--
V
--
L
A
A
A
E--
T
A
-----
R
----
Y
I
V
H
G
T
Q
G
S
Y
I
K
F
G
V
D
P
Q
E
D
----
R
L
-
K
A
G
E
R
LPQADWGYDMR
D
---
G
I
V
T
L
S
H
DN
V
-
L
--
T
---
E
----
K
----
P
L
L
-----
T
L
P
--
G
N
Y
P
A
Y
Y
A
G
I
R
D
A
I
-
W
G
T
A
P
N
--
P
V
P
A
T
E
A
I
K
V
M
E
L
I
E
L
G
I
A
--------------------
92
HHSearch
72.95
21%
-104
- C1 -
3RC1
7
?
A:
[28-342]
-------------------------------
I
R
V
G
V
I
G
C
A
-
D
I
A
W
-
R
R
A
-
L
P
A
L
E
A
-
E
-
P
--
L
T
E
V
T
A
I
A
S
R
---
R
W
D
R
A
K
R
F
T
E
R
F
G
G
--
E
P
V
----
E
------
G
Y
P
A
L
L
E
R
D
D
V
D
A
V
Y
V
P
L
P
A
V
L
H
A
E
W
I
D
R
A
L
R
A
G
K
H
V
L
A
E
K
P
L
T
T
D
R
P
Q
A
E
R
L
F
A
V
A
R
E
R
-
G
-
L
L
L
M
E
N
F
M
F
L
H
H
P
----
Q
H
R
Q
V
A
D
M
L
--
D
E
G
V
--
I
G
E
I
R
S
F
A
A
S
F
T
I
P
P
K
P
------------
Q
G
D
I
R
Y
Q
A
D
V
G
G
G
A
L
L
D
I
G
V
Y
P
I
R
A
A
G
L
F
L
G
----
A
D-
L
-
E
F
V
G
-
A
-
V
----
L
R
H
-
E
RD-----
R
D
--
V
V
V
G
G
N
A
L
L
T
T
-
R
Q
G
V
T
A
Q
L
T
--
F
G
--
M
--
E
H
A
Y
---
T
N
-----
N
----
Y
E
F
R
G
S
T
G
R
L
W
M
N
R
V
F
T
P
P
A
T
Y
Q
P
V
V
-
H
I
E
R
------------
Q
---
D
--------
H
-
A
--
E
---
Q
----
F
-----
V
L
-----
P
A
H
--
D
Q
F
A
K
S
I
R
A
F
A
Q
A
V
-
L
S
G
E
H
--
P
R
E
W
S
E
D
S
L
R
Q
A
S
L
V
D
A
V
R
T
--------------------
89
HHSearch
70.43
23%
-100
- C1 -
3EVN
-
?
A:
[6-317]
-------------------------------
V
R
Y
G
V
V
S
T
A
-
K
V
A
P
-
R
-
F
-
I
E
G
V
R
L
-
A
-
G
--
N
G
E
V
V
A
V
S
S
R
---
T
L
E
S
A
Q
A
---
K
Y
H
L
-
P
K
A
Y
----
D
------
K
L
E
D
M
L
A
D
E
S
I
D
V
I
Y
V
A
T
I
N
Q
D
H
Y
K
V
A
K
A
A
L
L
A
G
K
H
V
L
V
E
K
P
F
T
L
T
Y
D
Q
A
N
E
L
F
A
L
A
E
S
C
-
N
-
L
F
L
M
E
A
Q
K
S
V
F
I
P
----
M
T
Q
V
I
K
K
L
L
--
A
S
G
E
--
I
G
E
V
I
S
I
S
S
T
T
A
Y
P
N
I
------------
D
H
V
T
W
F
R
E
L
E
L
G
G
G
T
V
H
F
M
A
P
Y
A
L
S
Y
L
Q
Y
L
F
D
----
A
--
T
I
T
H
A
S
-
G
-
T
----
A
T
F
-
P
K------
G
Q
--
S
D
S
Q
S
K
L
L
L
Q
L
-
S
N
G
V
L
V
D
I
F
--
L
T
--
T
--
R
L
N
L
---
P
H
-----
E
----
M
I
I
Y
G
T
E
G
R
L
I
I
P
H
F
W
K
T
-
T
----
H
A
-
K
L
V
R
N
-----------
D
---
T
--------
S
-
A
--
R
---
T
----
I
-----
Q
V
-----
D
M
V
--
S
D
F
E
K
E
A
Y
H
V
S
Q
M
I
-
L
E
G
Q
R
V
S
H
I
M
T
P
Q
L
T
L
S
G
V
K
I
I
E
D
L
Y
R
--------------------
90
HHSearch
67.90
19%
-100
- C1 -
3CEA
1
?
A:
[9-334]
-------------------------------
L
R
A
A
I
I
G
L
G
-
R
L
G
E
-
R
-
H
-
A
R
H
L
V
N
K
I
-
Q
--
G
V
K
L
V
A
A
C
A
L
---
D
S
N
Q
L
E
W
A
K
N
E
L
G
V
-
E
T
T
Y
----
T
------
N
Y
K
D
M
I
D
T
E
N
I
D
A
I
F
I
V
A
P
T
P
F
H
P
E
M
T
I
Y
A
M
N
A
G
L
N
V
F
C
E
K
P
L
G
L
D
F
N
E
V
D
E
M
A
K
V
I
K
S
H
P
N
-
Q
I
F
Q
S
G
F
M
R
R
Y
D
D
----
S
Y
R
Y
A
K
K
I
V
--
D
N
G
D
--
I
G
K
I
I
Y
M
R
G
Y
G
I
D
P
I
S
G
M
E
---------
S
F
T
K
F
A
-
T
E
A
D
S
G
G
I
F
V
D
M
N
I
H
D
I
D
L
I
R
W
F
T
G
----
Q
D-
P
-
V
Q
A
Y
-
G
-
L
----
T
S
N
-
I
AA
P
Q
L
A
D
I
G
--
E
F
E
T
G
V
A
Q
L
K
M
-
S
D
G
V
I
A
T
L
I
--
G
G
--
R
--
H
A
A
H
G
N
-
Q
V
-----
E
----
L
E
V
M
G
S
N
G
W
V
R
I
G
E
H
P
D
L
-
N
----
R
V
-
T
V
F
N
D
-----------
Q
---
G
--------
V
-
V
--
R
---
P
----
S
L
QS-
F
G
E
-----
R
F
D
--
T
A
F
T
D
E
V
Q
D
F
V
N
N
V
-
I
V
G
K
Q
--
P
E
V
T
V
D
D
G
I
K
A
L
K
I
A
K
A
C
Q
Q
--------------------
102
HHSearch
66.83
18%
-95
- C1 -
3EZY
2
?
A:
[3-321]
-------------------------------
L
R
I
G
V
I
G
L
G
-
R
I
G
T
-
I
-
H
-
A
E
N
L
K
M
-
I
-
D
--
D
A
I
L
Y
A
I
S
D
V
---
R
E
D
R
L
R
E
M
K
E
K
L
G
V
-
E
K
A
Y
----
K
------
D
P
H
E
L
I
E
D
P
N
V
D
A
V
L
V
C
S
S
T
N
T
H
S
E
L
V
I
A
C
A
K
A
K
K
H
V
F
C
E
K
P
L
S
L
N
L
A
D
V
D
R
M
I
E
E
T
K
K
A
-
D
-
V
I
L
F
T
G
F
N
R
R
F
D
R
----
N
F
K
K
L
K
E
A
V
--
E
N
G
T
--
I
G
K
P
H
V
L
R
I
T
S
R
D
P
A
P
P
------------
P
L
D
Y
---
I
R
V
S
G
G
I
F
L
D
M
T
I
H
D
F
D
M
A
R
Y
I
M
G
----
E
E-
V
-
E
E
V
F
-
A
-
D
----
G
S
V
-
L
VD
E
E
I
G
K
A
G
--
D
V
D
T
A
V
V
V
L
R
F
-
K
S
G
A
L
G
V
I
D
--
N
S
--
R
--
R
A
V
Y
G
Y
-
D
Q
-----
R
----
I
E
V
F
G
S
K
G
R
I
F
A
D
N
V
R
E
--
T
----
T
V
-
V
L
T
D
E
-----------
Q
---
G
--------
D
-
R
G
S
R
---
Y
----
L
YF--
F
L
E
-----
R
Y
R
--
D
S
Y
L
E
E
L
K
T
F
I
K
N
V
-
K
S
G
E
P
--
P
A
V
S
G
E
D
G
K
M
A
L
L
L
G
Y
A
A
K
K
--------------------
88
HHSearch
66.70
19%
-88
- C1 -
1ZH8
7
?
A:
[19-328]
-------------------------------
I
R
L
G
I
V
G
C
G
-
I
A
A
R
-
E
L
H
-
L
P
A
L
K
N
-
L
-
S
H-
L
F
E
I
T
A
V
T
S
R
---
T
R
S
H
A
E
E
F
A
K
M
V
G
N
-
P
A
V
F
----
D
------
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
-
E
-
K
T
V
Y
I
A
E
N
F
R
H
V
P
----
A
F
W
K
A
K
E
L
V
--
E
S
G
A
--
I
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
E
N
N
K
Y
-------
V
H
T
D
W
R
K
K
P
K
H
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
----
E
--
I
-
E
W
I
S
-
A
-
V
----
A
K
D
-
L
SPL----
L
G
--
G
M
D
F
L
S
S
I
F
E
F
-
E
N
G
T
V
G
N
Y
T
--
I
S
--
Y
--
S
L
K
G
---
N
E
-----
R
----
F
E
I
T
G
T
K
G
K
I
S
I
S
W
D
K
---------
I
-
V
L
N
E
E
------------------------
E
------------------
M
K
V
-----
P
Q
E
--
N
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
-
A
E
G
K
P
N
-
D
L
G
S
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
--------------------
104
HHSearch
66.41
18%
-105
- C1 -
3MZ0
7
IOLG_BACSU
A:
[3-317]
-------------------------------
L
R
I
G
V
I
G
T
G
-
A
I
G
K
-
E
-
H
-
I
N
R
I
T
N
K
L
-
S
--
G
A
E
I
V
A
V
T
D
V
---
N
Q
E
A
A
Q
K
V
V
E
Q
Y
Q
L
N
A
T
V
Y
----
P
------
N
D
D
S
L
L
A
D
E
N
V
D
A
V
L
V
T
S
W
G
P
A
H
E
S
S
V
L
K
A
I
K
A
Q
K
Y
V
F
C
E
K
P
L
A
T
T
A
E
G
C
M
R
I
V
E
E
E
I
K
V
-
G
K
R
L
V
Q
V
G
F
M
R
R
Y
D
S
----
G
Y
V
Q
L
K
E
A
L
--
D
N
H
V
--
I
G
E
P
L
M
I
H
C
A
H
R
N
P
--
T
V
-----------
G
D
N
Y
-----
T
T
D
M
A
V
V
D
T
L
V
H
E
I
D
V
L
H
W
L
V
N
----
D
D
-
Y
-
E
S
V
Q
-
V
-
I
----
Y
P
K
-
K
SKNAL--
P
H
--
L
K
D
P
Q
I
V
V
I
E
T
-
K
G
G
I
V
I
N
A
E
--
I
Y
--
V
--
N
C
K
Y
GY-
D
I
-----
Q
----
C
E
I
V
G
E
D
G
I
I
K
L
P
E
P
S
--------
S
I
-
S
L
R
K
E
-----------
G
---
R
--------
F
-
S
--
T
---
D
I
L
M-
D
----
W
Q
R
-----
R
F
V
--
A
A
Y
D
V
E
I
Q
D
F
I
D
S
I
-
Q
K
K
G
E
V
-
S
G
P
T
A
W
D
G
Y
I
A
A
V
T
T
D
A
C
V
K
--------------------
18
PsiBlast_PDB
66.29
27%
-112
- C1 -
1H6B
2
GFO_ZYMMO
A:
[87-337]
----------------------------------
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
-
L
P
G
F
A
G
-
C
-
Q
--
H
S
R
I
E
A
L
V
S
G
---
N
A
E
K
A
K
I
V
A
A
E
Y
G
V
-
D
P
R
K
IYDY
S
------
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
------
Q
--
L
G
K
L
G
M
V
T
T
D
N
S
D
V
M
D
Q
N
D
P
A
Q
QWRL
R
R
E
L
A
--------
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E---
E
--
P
-
I
E
V
R
-
A
-
Y
T
Y
S
D
P
N
D
-
E
-------
R
F
--
V
E
V
E
D
R
I
I
W
Q
M
--
R
F
-
R
S
G
A
L
S
H
G
A
S
S
Y
--
S
T
T
T
---
T
S
-----
R
----
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
A
T
G
Y
Y
Q
----
N
L
-
I
S
V
Q
T
-----------
P
---
G
--------
H
-
A
--
N
---
Q
----
S
----
M
M
P
-----
Q
F
I
--
M
P
A
N
N
Q
F
S
A
Q
L
D
H
L
-
A
E
A
V
I
N
N
K
P
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
--------------------
80
Fugue
66.05
20%
-102
- C1 -
1OFG
2
GFO_ZYMMO
A:
[1-381]
ATLP
A
G
A
S
Q
VPT
T
P
A
G
R
P
MPYAI
R
P
M
P
E
D
RR
F
G
Y
A
I
V
G
L
G
-
K
Y
A
L
N
Q
-
I
-
L
P
G
F
A
-------
G
C
Q
H
S
R
I
E
A
L
V
S
G
N
A
E
K
A
K
I
V
A
A
E
--
Y
-
G
V
D
P
----
R
KIYDYS
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
----
M
N
R
A
A
V
K
L
I
--
R
--
E
NQ
L
G
K
L
G
M
V
T
T
D
N
S
D
V
M
D
Q
N
D
P
A
Q
----
Q
---
W
R
L
R
-
R
E
L
A
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
----
E
--
E
-
P
I
E
V
-
R
-
A
----
Y
T
Y
-
S
DPNDERF
V
E
--
V
E
D
R
I
I
W
Q
M
R
F
-
R
S
G
-
A
L
S
H
G
--
A
S
--
S
YS-
T
T
T
---
T
S
-----
R
----
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
A
T
G
Y
Y
Q
N
---
L
I
-
S
V
Q
T
P
-----------
G
---
H
--------
A
-
N
--
Q
---
S
M
M
PQ
F
----
I
M
P
-----
A
N
---
N
Q
F
S
A
Q
L
D
H
L
A
E
A
V
I
N
N
K
---
P
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
Y
E
A
A
R
T
G
R
P
V
N
TDWG
Y
V
R
Q
GGY
107
HHSearch
65.95
17%
-97
- C1 -
3Q2I
4
?
A:
[14-340]
-------------------------------
I
R
F
A
L
V
G
C
G
-
R
I
A
N
-
N
-
H
-
F
G
A
L
E
K
-
H
A
D
--
R
A
E
L
I
D
V
C
D
I
---
D
P
A
A
L
K
A
A
V
E
R
T
G
A
--
R
G
H
----
A
------
S
L
T
D
M
L
A
Q
T
D
A
D
I
V
I
L
T
T
P
S
G
L
H
P
T
Q
S
I
E
C
S
E
A
G
F
H
V
M
T
E
K
P
M
A
T
R
W
E
D
G
L
E
M
V
K
A
A
D
K
A
-
K
-
K
H
L
F
V
V
K
Q
N
R
R
N
A
----
T
L
Q
L
L
K
R
A
M
--
Q
E
K
R
--
F
G
R
I
Y
M
V
N
V
N
V
F
W
T
R
P
Q
--
E
Y
Y
----
D
--
A
A
G
W
R
G
T
W
E
F
D
G
G
A
F
M
N
Q
A
S
H
Y
V
D
L
L
D
W
L
I
G
----
P
--
V
-
E
S
V
Q
-
A
-
Y
----
T
A
T
-
L
ARN----
I
E
--
V
E
D
T
G
T
V
S
V
K
W
-
R
S
G
A
L
G
S
M
N
--
V
T
--
M
--
L
T
Y
P
KNL
E
G
-----
S
----
I
T
I
L
G
E
K
G
S
V
R
V
G
G
V
A
V
--
N
----
E
I
-
Q
H
W
E
F
-----------
S
EPH
A
--------
M
-
D
--
E
---
E
----
I
KDAS----------
G
--
F
G
H
P
L
Y
Y
D
N
V
I
K
T
M
-
R
G
E
A
T
--
P
E
T
D
G
R
E
G
L
K
S
L
E
L
L
I
A
M
Y
L
--------------------
19
PsiBlast_PDB
65.11
27%
-108
- C1 -
1H6A
1
GFO_ZYMMO
A:
[87-337]
----------------------------------
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
-
L
P
G
F
A
G
-
C
-
Q
--
H
S
R
I
E
A
L
V
S
G
---
N
A
E
K
A
K
I
V
A
A
E
Y
G
V
-
D
P
R
K
IYDY
S
------
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
------
Q
--
L
G
K
L
G
M
V
T
T
D
N
S
D
V
M
D
Q
N
D
P
A
Q
QWRL
R
R
E
L
A
--------
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E---
E
--
P
-
I
E
V
R
-
A
-
Y
T
Y
S
D
P
N
D
-
E
-------
R
F
--
V
E
V
E
D
R
I
I
W
Q
M
--
R
F
-
R
S
G
A
L
S
H
G
A
S
S
Y
--
S
T
T
T
---
T
S
-----
R
----
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
A
T
G
Y
Y
Q
----
N
L
-
I
S
V
Q
T
-----------
P
---
G
--------
H
-
A
--
N
---
Q
----
S
----
M
M
P
-----
Q
F
I
--
M
P
A
N
N
Q
F
S
A
Q
L
D
H
L
-
A
E
A
V
I
N
N
K
P
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
--------------------
16
PsiBlast_PDB
65.01
27%
-109
- C1 -
1H6D
2
GFO_ZYMMO
A:
[87-337]
----------------------------------
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
-
L
P
G
F
A
G
-
C
-
Q
--
H
S
R
I
E
A
L
V
S
G
---
N
A
E
K
A
K
I
V
A
A
E
Y
G
V
-
D
P
R
K
IYDY
S
------
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
------
Q
--
L
G
K
L
G
M
V
T
T
D
N
S
D
V
M
D
Q
N
D
P
A
Q
QWRL
R
R
E
L
A
--------
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E---
E
--
P
-
I
E
V
R
-
A
-
Y
T
Y
S
D
P
N
D
-
E
-------
R
F
--
V
E
V
E
D
R
I
I
W
Q
M
--
R
F
-
R
S
G
A
L
S
H
G
A
S
S
Y
--
S
T
T
T
---
T
S
-----
R
----
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
A
T
G
Y
Y
Q
----
N
L
-
I
S
V
Q
T
-----------
P
---
G
--------
H
-
A
--
N
---
Q
----
S
----
M
M
P
-----
Q
F
I
--
M
P
A
N
N
Q
F
S
A
Q
L
D
H
L
-
A
E
A
V
I
N
N
K
P
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
--------------------
15
PsiBlast_PDB
64.77
26%
-115
- C1 -
3E82
1
?
A:
[8-250]
-------------------------------
I
N
I
A
L
I
G
Y
G
-
F
V
G
K
-
T
-
F
H
A
P
L
I
R
S
-
V
-
P
--
G
L
N
L
A
F
V
A
S
---
R
D
E
E
K
V
K
R
D
L
P
D
V
T
V
--
I
A
S
----
P
------
E
--
A
A
V
Q
H
P
D
V
D
L
V
V
I
A
S
P
N
A
T
H
A
P
L
A
R
L
A
L
N
A
G
K
H
V
V
V
D
K
P
F
T
L
D
M
Q
E
A
R
E
L
I
A
L
A
E
E
K
-
Q
-
R
L
L
S
V
F
H
N
R
R
W
D
S
----
D
Y
L
G
I
R
Q
V
I
E
Q
G
--
T
--
L
G
A
V
K
H
F
E
S
H
F
D
R
F
R
P
E
V
----------------------
S
G
L
W
F
D
L
G
P
H
L
I
D
Q
A
L
Q
L
F
G
----
L
--
P
-
Q
S
V
Q
G
N
-
I
----
A
T
L
-
R
-------
D
G
AE
I
N
D
W
A
H
V
V
L
N
Y
-
P
A
H
-
K
V
I
L
----------
H
C
S
M
---
L
V
AGGSS
R
----
F
T
V
H
G
D
K
G
S
V
I
K
A
R
A
D
Q
Q
E
S
----
Q
L
-
L
A
G
V
V
-----------
P
---
G
--------
S
-
A
--
D
---
W
----
G
----
Q
D
D
-----
D
P
L
--
V
I
Y
D
A
S
L
Q
A
H
A
Q
A
T
-
P
Q
G
D
Q
R
Q
Y
Y
M
L
I
R
D
A
L
K
G
Q
I
A
N
P
V
P
P
V
--------------------
20
PsiBlast_PDB
64.50
27%
-107
- C1 -
1OFG
1
GFO_ZYMMO
A:
[35-285]
----------------------------------
A
I
V
G
L
G
K
Y
A
L
N
-
Q
-
I
-
L
P
G
F
A
G
-
C
-
Q
--
H
S
R
I
E
A
L
V
S
G
---
N
A
E
K
A
K
I
V
A
A
E
Y
G
V
-
D
P
R
K
IYDY
S
------
N
F
D
K
I
A
K
D
P
K
I
D
A
V
Y
I
I
L
P
N
S
L
H
A
E
F
A
I
R
A
F
K
A
G
K
H
V
M
C
E
K
P
M
A
T
S
V
A
D
C
Q
R
M
I
D
A
A
K
A
A
-
N
-
K
K
L
M
I
G
Y
R
C
H
Y
D
P
M
N
R
A
A
V
K
L
I
R
E
N
------
Q
--
L
G
K
L
G
M
V
T
T
D
N
S
D
V
M
D
Q
N
D
P
A
Q
QWRL
R
R
E
L
A
--------
G
G
G
S
L
M
D
I
G
I
Y
G
L
N
G
T
R
Y
L
L
G
E---
E
--
P
-
I
E
V
R
-
A
-
Y
T
Y
S
D
P
N
D
-
E
-------
R
F
--
V
E
V
E
D
R
I
I
W
Q
M
--
R
F
-
R
S
G
A
L
S
H
G
A
S
S
Y
--
S
T
T
T
---
T
S
-----
R
----
F
S
V
Q
G
D
K
A
V
L
L
M
D
P
A
T
G
Y
Y
Q
----
N
L
-
I
S
V
Q
T
-----------
P
---
G
--------
H
-
A
--
N
---
Q
----
S
----
M
M
P
-----
Q
F
I
--
M
P
A
N
N
Q
F
S
A
Q
L
D
H
L
-
A
E
A
V
I
N
N
K
P
V
R
S
P
G
E
E
G
M
Q
D
V
R
L
I
Q
A
I
--------------------
4
PsiBlast_PDB
64.49
25%
-99
- C1 -
2O4U
9
DHDH_MACFA
X:
[3-252]
-------------------------------
L
R
W
G
I
V
S
V
G
-
L
I
S
S
-
D
-
F
-
T
A
V
L
Q
T
-
L
-
P
--
R
S
E
H
Q
V
V
A
V
A
A
-
R
D
L
S
R
A
K
E
F
A
Q
K
H
D
I
-
P
K
A
Y
----
G
------
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
-
G
-
L
F
L
M
E
A
I
W
T
R
F
F
P
----
A
S
E
A
L
R
S
V
L
--
A
--
Q
GT
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
------------
H
V
P
R
A
V
-
D
W
A
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQKP
E
--
K
-
I
S
V
M
-
G
-
R
----
R
H
--
E
-------
T
G
--
V
D
D
T
V
T
V
L
L
Q
Y
P
G
E
V
-
H
------
G
S
--
F
--
T
C
S
I
---
T
A
-----
Q
LSNT
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
C
W
C
P
T
----
E
L
-
V
V
K
G
E
-----------
H
---
K
--------
E
-
F
--
L
---
L
----
P
----
P
V
P
-----
K
N
C
--
N
F
D
N
G
A
G
M
S
Y
E
A
K
H
-
V
R
E
C
L
R
K
G
L
K
E
S
P
V
I
P
L
V
E
S
E
L
L
A
D
I
L
--------------------
2
PsiBlast_PDB
64.46
31%
-94
- C1 -
2HO5
-
?
A:
[2-247]
-------------------------------
L
K
L
G
V
I
G
T
G
-
A
I
S
H
-
H
-
F
-
I
E
A
A
H
T
-
S
-
G
--
E
Y
Q
L
V
A
I
Y
S
---
R
K
L
E
T
A
A
T
F
A
S
R
Y
-
Q
-
N
I
Q
L
----
F
------
D
Q
L
E
V
F
F
K
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
-
N
-
C
F
I
F
E
A
A
R
N
Y
H
E
K
----
A
F
T
T
I
K
N
F
L
--
A
--
D
---
K
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
-----------------------
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
----
K
--
A
-
N
D
A
T
-
Y
H
A
----
Q
Q
L
-
D
-------
N
S
--
I
D
L
N
G
D
G
I
L
F
Y
-
P
D
Y
-
Q
V
H
I
K
--
A
G
--
K
--
N
I
T
S
---
N
L
-----
P
----
C
E
I
Y
T
T
D
G
T
L
T
L
N
T
I
E
H
I
R
S
----
A
I
-
F
T
D
H
Q
-----------
G
---
N
--------
Q
-
V
--
Q
---
L
----
P
----
I
Q
Q
-----
A
P
H
--
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
-
Q
P
D
L
N
L
Y
Q
T
W
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
T
--------------------
100
HHSearch
64.38
16%
-95
- C1 -
3EUW
1
?
A:
[5-322]
-------------------------------
L
R
I
A
L
F
G
A
G
-
R
I
G
H
-
V
-
H
-
A
A
N
I
A
A
-
N
-
P
--
D
L
E
L
V
V
I
A
D
P
---
F
I
E
G
A
Q
R
L
A
E
A
N
G
A
--
E
A
V
----
A
------
S
P
D
E
V
F
A
R
D
D
I
D
G
I
V
I
G
S
P
T
S
T
H
V
D
L
I
T
R
A
V
E
R
G
I
P
A
L
C
E
K
P
I
D
L
D
I
E
M
V
R
A
C
K
E
K
I
G
D
G
-
A
-
S
K
V
M
L
G
F
N
R
R
F
D
P
----
S
F
A
A
I
N
A
R
V
--
A
N
Q
E
--
I
G
N
L
E
Q
L
V
I
I
S
R
D
P
A
P
A
------------
P
K
D
Y
I
---
A
G
S
G
G
I
F
R
D
M
T
I
H
D
L
D
M
A
R
F
F
V
P
----
N
--
I
-
V
E
V
T
-
A
-
T
----
G
A
N
-
V
F
S
Q
E
I
A
E
F
N
--
D
Y
D
Q
V
I
V
T
L
R
G
-
S
K
G
E
L
I
N
I
V
--
N
S
--
R
--
H
C
S
Y
G
Y
-
D
Q
-----
R
----
L
E
A
F
G
S
K
G
M
L
A
A
D
N
I
R
P
--
T
----
T
V
-
R
K
H
N
A
-----------
E
---
S
--------
T
E
Q
A
-
D
---
P
----
I
FNF-
F
L
E
-----
R
Y
D
--
A
A
Y
K
A
E
L
A
T
F
A
Q
G
I
-
R
D
G
Q
G
--
F
S
P
N
F
E
D
G
V
I
A
L
E
L
A
N
A
C
L
E
--------------------