@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1625: (2015-12-09 )
MDLKRTQPKLLEKFNTILQSDRMSHAYLFSGNFASLDMALYLAQSQFCEKRQSGLPCQKCRACRLIANGEFSDVKIIEPQGQLIKTETIKELTKDFSRSGFEGKSQVFIIKDCEKMHVNAANSLLKFIEEPQSSSYVILLTNDENNVLPTIKSRTQIFRFPKQLDMLVHQAEQAGLLKSQASLLAQVADDPKHLEILLANKKLLDYLNLSQQFVTTLAKDRQTAYLEVSRLTSQVVDKNDQAFVFQWLTIMLAKEGQLYDLENTYRAQQMWKSNVSFQNSLEYMVLS
Atome Classification :
(20 SA)
------------.........10........20-------.........30--.--.--......40........50.-.......----60........70........80........-90-...-.....----100------..-.-......110....-..-.120.......130---------.........140.--------------------------......150...-....160.--------.-..------..--...170-----------.------------.-----..-----------.--..--..180.......190..---....--..200......--------.210.......220.......230.......240.......250..--------.....260.......270.......280.....---------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MDLKRT
Q
P
K
L
L
E
K
F
N
T
I
L
Q
S--------DRM
S
H
A
Y
L
FSG--N--
F
--
A
S
L
D
M
A
L
Y
L
A
Q
S
Q
F
C
E
K
R
Q-SGL
P
C
Q
K
----
C
R
A
C
R
L
I
ANGEFS
D
V
K
I
IEPQG
Q
L
I
K
T
E
T
I
-
K
E
-
L
T
K
-
D
F
S
RS----G--------FE-G-K
S
Q
V
F
I
IKD
C
E
K
M
-
H
V
-
N
A
A
N
S
L
L
K
F
I
EE-----------PQSS
S
Y
V
I
L
L
TND--------------------------ENNVLP
T
I
KS
R
T
-
Q
I
F
R
F
--
P
--------
K
-
Q
L
------
D
M
--
L
V
H
Q
-------------
A
------------
E
-----
Q
A-----------
G
--
L
L
--
K
S
Q
A
S
L
L
A
Q
VADDP-K
H
---
L
E
I
L
--LAN
K
K
L
L
D
Y
L
N
--------
L
S
Q
Q
F
V
T
T
L
A
KDR
Q
T
A
Y
L
E
V
S
R
L
T
S
Q
V
VDKND
Q
A
F
V
F
Q
W
L
T
I
M
L
AK--------EGQLY
D
L
E
N
T
Y
R
A
Q
Q
M
W
K
SNVSFQNS
L
E
Y
M
V
LS---------------------------------
3
PsiBlast_PDB
98.26
29%
-96
- C5 -
3GLI
4
DPO3X_ECOLI
B:
[43-272]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
2
PsiBlast_PDB
97.60
29%
-95
- C5 -
3GLF
4
DPO3X_ECOLI
B:
[43-272]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
7
PsiBlast_PDB
96.98
29%
-95
- C5 -
3GLG
4
DPO3X_ECOLI
B:
[43-272]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
A
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
5
PsiBlast_PDB
95.33
29%
-88
- C5 -
1JR3
2
DPO3X_ECOLI
A:
[21-250]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
1
PsiBlast_PDB
94.25
29%
-90
- C5 -
1XXI
2
DPO3X_ECOLI
B:
[21-250]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
4
PsiBlast_PDB
94.23
29%
-91
- C5 -
3GLH
-
DPO3X_ECOLI
B:
[21-250]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
--
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
-
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
6
PsiBlast_PDB
93.58
29%
-87
- C5 -
1XXH
2
DPO3X_ECOLI
B:
[21-250]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
--
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
--------
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
---------------------------------
9
PsiBlast_PDB
91.74
29%
-90
- C5 -
1NJF
3
DPO3X_ECOLI
A:
[28-247]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.42
29%
-91
- C5 -
1NJG
3
DPO3X_ECOLI
A:
[28-247]
------------------
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
--
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
-
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
-----------
K
-
A
L
------
D
V
E
Q
I
R
H
Q
-------------
L
------------
E
-----
H
---------------
I
L
--
N
E
E
-----
H
I
A
H
E
P
-
R
A
---
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
--------
L
T
D
Q
A
I
A
S
--
G
D
G
Q
V
S
T
Q
A
V
S
A
M
L
G
T
----------------------------------------------------------------------------------------------
43
Fugue
89.42
22%
-84
- C5 -
1JR3
2
DPO3X_ECOLI
A:
[3-368]
YQV
L
A
R
K
W
RPQT
F
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
--
T
RG
V
--
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
R
T
-
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
--
K
A
L
D
V
E
Q
I
R
H
-
Q
L
------
E
H
--
I
L
N
E
E
H
I
A
H
E
P
R
A
L
Q
L
L
A
------------
R
-----
A
A
E----------
G
--
S
L
--
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
-
D
G
QVS
T
Q
A
V
--
S
A
M
L
G
T
L
D
D
D
Q
--------
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
SPAAL
G
N
D
M
A
A
I
E
L
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
PYAPD
R
R
M
G
V
E
M
T
L
L
R
A
L
A
F
HPRMPLPEP
22
HHSearch
83.77
26%
-85
- C5 -
1NJG
3
DPO3X_ECOLI
A:
[23-230]
-------------
A
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
--
T
--
R
GV
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
-
R
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
--
K
--------
A
L
D
V
------
E
Q
--
I
R
H
Q
-------------
L
------------
E
-----
H
I
L
N
E
E
-------
H
I
A
H
E
P
-
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
-
R
D
---
A
L
S
L
--
T
D
Q
A
I
A
S
G
D
G
Q
--------
V
S
T
Q
A
V
S
A
M
L
G
T
------------------------------------------------------------------------------------------------------------
26
HHSearch
81.71
26%
-89
- C5 -
1JR3
2
DPO3X_ECOLI
A:
[17-223]
--------------
D
V
V
G
Q
E
H
V
L
T
A
L
A
N
G
L
S
L
--------
G
R
I
H
H
A
Y
L
F
S
G
--
T
--
R
GV
G
K
T
S
I
A
R
L
L
A
K
G
L
N
C
E
T
G
I
-
T
A
T
P
C
G
V
----
C
D
N
C
R
E
I
E
Q
G
R
F
V
D
L
I
E
I
D
A
A
S
-
R
T
K
V
E
D
T
-
R
D
-
L
L
D
-
N
V
Q
Y
A
----
P
--------
A
R
-
G
-
R
F
K
V
Y
L
I
D
E
V
H
M
L
-
S
R
-
H
S
F
N
A
L
L
K
T
L
E
E
-----------
P
P
E
H
V
K
F
L
L
A
T
T
D
--------------------------
P
Q
K
L
P
V
T
I
L
S
R
C
-
L
Q
F
H
L
--
K
--------
A
L
D
V
------
E
Q
--
I
R
H
Q
-------------
L
------------
E
-----
H
I
L
N
E
E
-------
H
I
A
H
E
P
-
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
-
R
D
---
A
L
S
L
--
T
D
Q
A
I
A
S
G
D
G
Q
--------
V
S
T
Q
A
V
S
A
M
L
G
T
L
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
A
N
G
E
R
V
M
A
L
I
N
E
A
A
A
R
G
I
E
--------
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
E
---------------------------------
35
HHSearch
69.80
19%
-106
- C5 -
1IQP
1
RFCS_PYRFU
A:
[26-214]
--------------
D
I
V
G
Q
E
H
I
V
K
R
L
K
H
Y
V
K
T
--------
G
S
M
-
P
H
L
L
F
A
G
--
P
--
P
GV
G
K
T
T
A
A
L
A
L
A
R
E
L
F
G
E
N
W
------------------------
R
H
N
F
L
E
L
N
A
S
D
-
E
R
G
I
N
V
I
-
R
E
K
V
K
E
-
F
A
R
T
K
----
P
--------
I
G
-
G
A
S
F
K
I
I
F
L
D
E
A
D
A
L
-
T
Q
-
D
A
Q
Q
A
L
R
R
T
M
E
M
-----------
F
S
S
N
V
R
F
I
L
S
C
N
Y
--------------------------
S
S
K
I
I
E
P
I
Q
S
R
C
-
A
I
F
R
F
--
R
--------
P
L
R
D
------
E
D
--
I
A
K
R
-------------
L
------------
R
-----
Y
I
A
E
N
E
-------
G
LE
L
T
E
-
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
-
R
R
---
A
I
N
I
--
L
Q
A
A
A
A
L
D
K
K
I
--------
T
D
E
N
V
F
M
V
A
S
R
A
R
P
E
D
I
R
E
M
M
L
L
A
L
K
G
N
F
L
K
A
R
E
K
L
R
E
I
L
L
K
Q
G
L
S
--------
G
E
D
V
L
V
Q
M
H
K
E
V
F
N
L
P
I
E
E
P
K
K
V
L
L
A
D
K
I
G
E
Y
N
---------------------------------
38
HHSearch
69.71
21%
-96
- C5 -
1QVR
3
CLPB_THET8
A:
[559-767]
--------------
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
AGLKDP
N
R
P
I
G
S
F
L
F
L
G
--
P
--
T
GV
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
YMEK
H
A
V
S
R
L
--------------------------
Q
-
L
T
E
-
A
V
R
R
R
------------------
P
Y
S
V
I
L
F
D
E
I
E
K
A
-
H
P
-
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
SHGRTV
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
GWP
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
--
R
--------
P
L
T
K
------
E
Q
--
I
R
Q
I
-------------
V
------------
E
-----
I
Q
-----------
L
--
S
Y
--
L
R
A
R
L
A
E
K
R
I
S
L
E
L
-
T
E
---
A
A
K
D
--
F
L
A
E
R
G
Y
D
P
V
F
--------
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
--------
A
-----------------------------------------------------------------
31
HHSearch
69.61
16%
-87
- C5 -
2CHG
2
RFCS_ARCFU
A:
[18-206]
--------------
E
V
V
G
Q
D
E
V
I
Q
R
L
K
G
Y
V
E
R
--------
K
N
I
P
H
-
L
L
F
S
G
--
P
--
P
GT
G
K
T
A
T
A
I
A
L
A
R
D
L
F
G
E
N
W
R
------------------------
D
N
F
I
E
M
N
A
S
D
-
E
R
G
I
D
V
V
-
R
H
-
K
I
K
E
F
A
R
T
A
----
P
--------
I
G
G
A
-
P
F
K
I
I
F
L
D
E
A
D
A
L
-
T
A
-
D
A
Q
A
A
L
R
R
T
M
E
M
-----------
Y
S
K
S
C
R
F
I
L
S
C
N
Y
--------------------------
V
S
R
I
I
E
P
I
Q
S
R
C
-
A
V
F
R
F
--
K
--------
P
V
P
K
------
E
A
--
M
K
K
R
-------------
L
------------
L
-----
E
I
C
E
K
E
-------
G
V
K
I
T
E
-
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
-
R
K
---
A
I
N
A
--
L
Q
G
A
A
A
I
G
E
V
V
--------
D
A
D
T
I
Y
Q
I
T
A
T
A
------------------------------------------------------------------------------------------------------------
44
Fugue
68.93
18%
-55
- C5 -
2GNO
3
?
A:
[4-299]
------------
D
Q
L
E
T
L
K
R
I
I
E
K
S
E
G
I
S
I
L
I
--------
N
G
E
D
-------------------------------
L
S
Y
-
P
R
E
V
S
L
E
----
L
P
E
Y
V
E
K
F
P
P
K
A
S
D
V
L
E
I
D
P
E
G
E
N
I
G
I
D
D
I
-
R
T
-
I
K
D
-
F
L
N
Y
S
----
P
--------
E
L
-
Y
-
T
R
K
Y
V
I
V
H
D
C
-
E
R
M
T
Q
-
Q
A
A
N
A
F
L
K
A
L
E
E
-----------
P
P
E
Y
A
V
I
V
L
N
T
R
R
--------------------------
W
H
Y
L
L
P
T
I
K
S
R
V
-
F
R
V
V
V
N
V
P
--------
K
-
E
F
------
R
D
--
L
V
K
E
-------------
K
I
GD
L
W
E
E
L
P
L
L
E
R
-----
D
F
-----------
K
--
T
A
--
L
E
A
Y
K
L
G
A
E
K
L
S
G
L
M
E
S
---
L
K
V
L
---
E
T
E
K
L
L
K
K
V
L
SKG
L
E
G
Y
L
A
C
R
E
L
L
E
R
F
S
K
V
E
S
K
E
F
F
A
L
F
D
Q
V
T
N
T
I
T
G
K
D
A
F
L
L
I
Q
R
L
T
R
I
I
L
H
--------
E
N
T
W
E
S
V
E
D
Q
K
S
V
S
F
L
D
S
I
L
R
V
K
I
A
N
L
N
N
K
L
T
L
M
N
I
L
A
I
H
R
E
R
K
R---------------------
24
HHSearch
68.38
17%
-89
* C5 *
2CHQ
1
RFCS_ARCFU
A:
[17-207]
-------------
D
E
V
V
G
Q
D
E
V
I
Q
R
L
K
G
Y
V
E
R
--------
K
N
I
P
H
-
L
L
F
S
G
--
P
--
P
GT
G
K
T
A
T
A
I
A
L
A
R
D
L
F
G
E
N
W
R
------------------------
D
N
F
I
E
M
N
A
S
D
-
E
R
G
I
D
V
V
R
H
K
-
I
K
E
-
F
A
R
T
A
----
P
--------
I
G
-
G
A
P
F
K
I
I
F
L
D
E
A
D
A
L
-
T
A
-
D
A
Q
A
A
L
R
R
T
M
E
M
-----------
Y
S
K
S
C
R
F
I
L
S
C
N
Y
--------------------------
V
S
R
I
I
E
P
I
Q
S
R
C
-
A
V
F
R
F
--
K
--------
P
V
P
K
------
E
A
--
M
K
K
R
-------------
L
------------
L
-----
E
I
C
E
KE-------
G
V
K
I
T
E
-
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
-
R
K
---
A
I
N
A
--
L
Q
G
A
A
A
I
G
E
V
V
--------
D
A
D
T
I
Y
Q
I
T
A
T
A
R
P
E
E
M
T
E
L
I
Q
T
A
L
K
G
N
F
M
E
A
R
E
L
L
D
R
L
M
V
E
Y
G
M
S
--------
G
E
D
I
V
A
Q
L
F
R
E
I
I
S
M
P
I
K
D
S
L
K
V
Q
L
I
D
K
L
G
E
V
D
---------------------------------
30
HHSearch
68.13
19%
-100
- C5 -
3U61
4
DPA44_BPT4
B:
[26-218]
-------------
D
E
C
I
L
P
A
F
D
K
E
T
F
K
S
I
T
S
K
--------
G
K
I
P
H
I
I
L
H
S
P
--
S
--
P
GT
G
K
T
T
V
A
K
A
L
C
H
D
V
N
A
D
M
-----------------------------
M
F
V
N
G
S
--
D
C
K
I
D
F
V
-
R
G
P
L
T
N
-
F
A
S
A
A
----
S
--------
F
D
-
G
-
R
Q
K
V
I
V
I
D
E
F
D
R
S
-
G
L
A
E
S
Q
R
H
L
R
S
F
M
E
A
-----------
Y
S
S
N
C
S
I
I
I
T
A
N
N
--------------------------
I
D
G
I
I
K
P
L
Q
S
R
C
-
R
V
I
T
F
--
G
--------
Q
P
T
D
------
E
D
--
K
I
E
M
-------------
M
------------
K
-----
Q
M
I
R
R
L
T
E
I
C
K
H
E
G
IA
I
A
D
M
K
V
V
A
A
L
V
K
K
N
F
P
D
F
-
R
K
---
T
I
G
E
--
L
D
S
Y
S
S
K
G
V
L
D
--------
A
I
D
D
V
L
E
S
L
K
N
K
D
V
K
Q
L
R
A
L
A
P
K
Y
A
A
D
Y
S
W
F
V
G
K
L
A
E
E
I
Y
S
R
V
T
P
Q
--------
S
I
I
R
M
Y
E
I
V
G
E
N
N
Q
Y
H
G
I
A
A
N
T
E
L
H
L
A
Y
L
F
I
Q
L
---------------------------------
33
HHSearch
68.00
17%
-93
- C5 -
1SXJ
3
RFC2_YEAST
D:
[38-236]
--------------
E
V
T
A
Q
D
H
A
V
T
V
L
K
K
T
L
K
S
--------
A
N
L
P
H
-
M
L
F
Y
G
--
P
--
P
GT
G
K
T
S
T
I
L
A
L
T
K
E
L
Y
G
P
D
L
M
-----------------------
K
S
R
I
L
E
L
N
A
S
D
-
E
R
G
I
S
I
V
-
R
E
-
K
V
K
-
N
F
A
R
L
T
V
S
K
P
S
K
H
D
L
E
NY
P
C
-
P
-
P
Y
K
I
I
I
L
D
E
A
D
S
M
-
T
A
-
D
A
Q
S
A
L
R
R
T
M
E
T
-----------
Y
S
G
V
T
R
F
C
L
I
C
N
Y
--------------------------
V
T
R
I
I
D
P
L
A
S
Q
C
-
S
K
F
R
F
--
K
--------
A
L
D
A
------
S
N
--
A
I
D
R
-------------
L
------------
R
-----
F
I
S
E
Q
E
-------
N
VK
C
D
D-
G
V
L
E
R
I
L
D
I
S
A
G
D
L
-
R
R
---
G
I
T
L
--
L
Q
S
A
S
K
G
A
Q
Y
L
--------
G
D
G
K
N
I
T
S
T
Q
V
E
E
L
A
G
V
V
P
H
D
I
L
I
E
I
V
E
K
V
K
S
G
D
F
D
E
I
K
K
Y
V
N
T
F
M
--------
K
S
G
W
S
A
A
S
V
V
N
Q
L
H
E
Y
Y
I
T
N
D
N
F
D
T
N
F
K
N
Q
I
S
W
---------------------------------
25
HHSearch
67.81
23%
-97
- C5 -
2GNO
3
?
A:
[4-191]
--------------------
D
Q
L
E
T
L
K
R
I
I
E
K
--------
S
E
-
G
I
S
I
L
I
N
G
--
E
--
D
LS
Y
P
R
E
V
S
L
E
L
P
E
Y
V
E
K
F
P
P
-----------------------
K
A
S
D
V
L
E
I
D
P
E
G
E
N
I
G
I
D
D
I
-
R
T
-
I
K
D
-
F
L
N
Y
S
----
P
--------
E
L
-
Y
-
T
R
K
Y
V
I
V
H
D
C
E
R
M
-
T
Q
-
Q
A
A
N
A
F
L
K
A
L
E
E
-----------
P
P
E
Y
A
V
I
V
L
N
T
R
R
--------------------------
W
H
Y
L
L
P
T
I
K
S
R
V
-
F
R
V
V
V
--
N
--------
V
P
K
E
F
R
D
L
V
K
E
K
--
I
G
D
L
-------------
W
------------
E
E
L
P
L
L
E
R
-----------
D
F
K
T
A
L
-
E
A
Y
K
L
G
A
E
K
L
S
G
L
M
-
E
----
S
L
K
V
--
L
E
T
E
K
L
L
K
K
V
L
--------
S
K
G
L
E
G
Y
L
A
C
R
E
L
L
E
R
F
S
K
V
E
S
K
E
F
F
A
L
F
D
Q
V
T
N
T
I
T
G
K
D
A
F
L
L
I
Q
--------
R
L
T
R
I
I
L
H
E
N
T
W
E
S
V
E
D
Q
K
S
V
S
F
L
D
S
I
L
R
V
K
I
A
---------------------------------