@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1639: (2015-12-09 )
MRIIVVGGGKVGTALCRSLVAEKHDVVLIEKKENVLKRVTKQHDIMGIVGNGANYKILEQAEVKNCDIFIAITDRDEVNMISAVLAKKMGAKETVVRMRNPEYSNPYFKDKNFLGFSSVVNPELLAAQYIANTIEFPNATSVEHFANGRVMLMEFKILEGNKLCHTSMSQIRKKFGNIVICAIERDGKLIIPDGDATIQVKDKIFVTGNRIEMILFHNYVKNKVVKNLMVIGAGRIAYYLLNILKNTNTHVKLVELNQEQAEYFSQEFPNVPVVHGDGTAKNILLEESVTSFDAVATLTGVDEENIITSMFLESIGIPKNITKVNRTSLLEIIDDKQLSSIITPKRIAVDHVMHFVRGRVNAQDSNLEAMHHIANDRIETLQFEIKETSKLANRSLASLKLKQNILIAAIIRNNKTIFPTGEDVLTVGDRIVVITLLKNITRTSDMLAR
Atome Classification :
(20 SA)
---.........10--..--......20.-----..-----.....30...--....-.40....----.....50........60........70....--------....80........-.-90-........100.---......110..------...---..120.......130...---....-140.-..---------.-------------------..----.150.......160....---------...170.---...---..--.180......-.-190.......200...--....210...------------------------------------....-------------------------------.-220--.........230.-------...------...240..------...------..250.......260...--.--...270.......280.......290.......300.......310..-..--------...320-.......330.....-----------------..340.......350---------.......360.......-370..-...-..----------------------------380....---...390.......400.--.--..--.....410..----------..-.--------.-.420.......430.......440.......-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---
M
R
I
I
V
VGGG
K
V
--
G
T
--
A
L
C
R
S
L
V
AE-----KH-----
D
V
V
L
I
E
K
K
E
N
--
V
L
K
R
-
V
T
-
K
QHD----
I
M
G
I
VGNGA
N
Y
K
I
L
E
Q
AEVKNC
D
I
F
I
A
ITDR--------D
E
V
N
M
-
I
S
A
V
L
A
K
K-M-GA-K
E
T
V
VRMRNPEY---SNPYFKDKNFL------G
F
S
---SVV
N
P
E
L
L
A
A
Q
Y
I
A
N
T
IE---FPNA-T
S
V
E
-
H
F---------A-------------------N
G
----
R
V
M
L
M
E
F
K
ILEGNKL
C
H
T
---------
S
M
S
Q
I
R
K
---KFG---
N
I
--
V
I
C
A
IERD
G
K
-
L
-
I
IPDGD
A
T
I
Q
V
K
D
K
I
F
--
V
TG
N
R
-
I
E
M
I
------------------------------------
L
F
H
N
-------------------------------
Y
-
V
----
K
N
K
V
V
K
N
L
M
V
IG
A
-------
G
R
I
------
A
Y
Y
L
L
N
I
L------KNT------NT
H
V
K
L
V
EL
N
Q
E
Q
A
E
Y
F
S
--
Q
--EFPNV
P
V
V
HGDGTA
K
N
I
L
LEESVTSFD
A
V
A
T
LTGV
D
E
E
N
I
I
T
S
M
F
L
E
S-IG--------IPKN
I
T
-KV
N
R
T
S
L
L
E
I
I
D
D
K
Q
-----------------
L
S
S
IIT
P
K
R
I
A
V
D
H
V
---------
M
H
F
V
R
GRVNAQDS
N
L
E
A
-
M
H
H
I
A-NDR-
I
E
----------------------------
T
L
Q
F
E
I
K
---
E
T
S
K
L
ANR
S
L
A
S
L
K
--L--K--Q
N
--
I
L
I
A
A
I
IRNN----------
K
T
-
I
--------F-PTGED
V
L
TVG
D
R
I
V
V
I
T
L
L
K
N
I
T
R
T
S
D
MLAR-------------------------
3
PsiBlast_PDB
89.44
27%
-99
- C2 -
4G65
9
?
A:
[5-431]
----
K
I
I
I
L
G
A
G
Q
V
--
G
G
--
T
L
A
E
N
L
V
G
E
-----
N
N
-----
D
I
T
I
V
D
K
D
G
D
--
R
L
R
E
-
L
Q
-
D
K
Y
D
----
L
R
V
V
N
G
H
A
S
H
P
D
V
L
H
E
A
G
A
Q
D
A
D
M
L
V
A
V
T
N
T
--------
D
E
T
N
M
-
A
A
C
Q
V
A
F
T
-
L
F
N
T
-
P
N
R
I
A
R
I
R
S
P
Q
Y
L
A
Q
K
E
A
L
F
K
-
S
G
A
I
------
P
V
D
---
H
L
I
A
P
E
E
L
V
T
S
Y
I
E
R
L
I
Q
---
Y
P
G
A
-
L
Q
V
V
-
S
F
---------
A
-------------------
E
E
----
K
V
S
L
V
A
V
K
A
Y
Y
G
G
P
L
V
G
N
---------
A
L
S
A
L
R
E
---
H
M
P
---
H
I
D
T
R
V
A
A
I
F
R
Q
G
R
-
P
-
I
R
P
Q
G
T
T
I
I
E
A
D
D
E
V
F
F
V
A
A
S
N
H
-
I
R
S
V
------------------------------------
M
S
E
L
-------------------------------
Q
-
R
----
L
E
K
P
Y
R
R
I
M
I
V
G
G
-------
G
N
I
------
G
A
S
L
A
K
R
L
------
E
Q
T
------
Y
S
-
V
K
L
I
E
R
N
L
Q
R
A
E
K
L
S
--
E
--
E
L
E
N
T
I
V
F
C
G
D
A
A
D
Q
E
L
L
T
E
E
N
I
D
Q
V
D
V
F
I
A
L
T
N
E
D
E
T
N
I
M
S
A
M
L
A
K
R
-
M
G
--------
A
K
K
V
M
V
-
L
I
Q
R
G
A
Y
V
D
L
V
Q
G
G
V
-----------------
I
D
V
A
I
S
P
Q
Q
A
T
I
S
A
L
---------
L
T
H
V
R
---
R
A
D
I
V
N
V
S
S
-
L
R
R
G
A
-
A
E
A
-
I
E
----------------------------
A
V
A
H
G
D
E
---
S
N
S
K
V
V
G
R
A
V
G
D
I
K
--
L
--
P
--
P
G
--
T
T
I
G
A
I
V
R
----------------------------
G
E
E
V
L
I
A
H
D
R
T
V
I
E
Q
D
D
H
V
V
M
F
L
V
D
K
K
Y
V
-------------------------
2
PsiBlast_PDB
89.34
27%
-105
- C2 -
4J9V
3
?
A:
[1-428]
---
M
K
I
I
I
L
G
A
G
Q
V
--
G
G
--
T
L
A
E
N
L
V
G
E
-----
N
N
-----
D
I
T
I
V
D
N
N
A
D
--
R
L
R
E
-
L
Q
-
D
K
Y
D
----
L
R
V
V
N
G
H
A
S
H
P
D
V
L
H
E
A
G
A
Q
D
A
D
M
L
V
A
V
T
N
T
--------
D
E
T
N
M
-
A
A
C
Q
V
A
F
T
-
L
F
N
T
-
P
N
R
V
A
R
I
R
S
P
E
Y
L
A
E
K
E
A
L
F
K
-
S
G
A
I
------
P
V
D
---
H
L
I
A
P
E
E
L
V
T
S
Y
I
E
R
L
I
Q
---
Y
P
G
A
-
L
Q
V
V
-
S
F
---------
A
-------------------
E
Q
----
K
V
S
L
V
A
V
K
A
Y
Y
G
G
P
L
V
G
N
---------
A
L
S
A
L
R
E
---
H
M
P
---
H
I
D
T
R
V
A
A
I
F
R
Q
G
R
-
P
-
I
R
P
Q
G
T
T
I
I
E
A
D
D
E
V
F
F
V
A
A
S
N
H
-
I
R
S
V
------------------------------------
M
S
E
L
-------------------------------
Q
-
R
----
L
E
K
P
Y
R
R
I
M
I
V
G
G
-------
G
N
I
------
G
A
S
L
A
K
R
L
------
E
Q
T
------
Y
S
-
V
K
L
I
E
R
D
Y
Q
R
A
E
K
L
S
--
E
--
Q
L
E
N
T
I
V
F
C
G
D
A
A
D
Q
E
L
L
T
E
E
N
I
D
Q
V
D
V
F
I
A
L
T
N
E
D
E
T
N
I
M
S
A
M
L
A
K
R
-
M
G
--------
A
K
K
V
M
V
-
L
I
Q
R
G
A
Y
V
D
L
V
Q
G
G
V
-----------------
I
D
V
A
I
S
P
Q
Q
A
T
I
S
A
L
---------
L
T
H
V
R
---
R
A
D
I
V
N
V
S
S
-
L
R
R
G
A
-
A
E
A
-
I
E
----------------------------
A
V
A
H
G
D
E
---
T
T
S
K
V
V
G
R
A
I
G
D
I
K
--
L
--
P
--
P
G
--
T
T
I
G
A
V
V
R
----------------------------
G
E
E
V
L
I
A
H
D
R
T
V
I
E
Q
D
D
H
V
V
M
F
L
V
D
K
K
Y
V
-------------------------
1
PsiBlast_PDB
88.15
27%
-105
- C2 -
4J9U
11
?
E:
[1-428]
---
M
K
I
I
I
L
G
A
G
Q
V
--
G
G
--
T
L
A
E
N
L
V
G
E
-----
N
N
-----
D
I
T
I
V
D
N
N
A
D
--
R
L
R
E
-
L
Q
-
D
K
Y
D
----
L
R
V
V
N
G
H
A
S
H
P
D
V
L
H
E
A
G
A
Q
D
A
D
M
L
V
A
V
T
N
T
--------
D
E
T
N
M
-
A
A
C
Q
V
A
F
T
-
L
F
N
T
-
P
N
R
V
A
R
I
R
S
P
E
Y
LAE
K
E
A
L
F
K
-
S
G
A
I
------
P
V
D
---
H
L
I
A
P
E
E
L
V
T
S
Y
I
E
R
L
I
Q
---
Y
P
G
A
-
L
Q
V
V
-
S
F
---------
A
-------------------
E
Q
----
K
V
S
L
V
A
V
K
A
Y
--
G
P
L
V
G
N
---------
A
L
S
A
L
R
E
---
H
-------
D
T
R
V
A
A
I
F
R
Q
G
R
-
P
-
I
R
P
Q
G
T
T
I
I
E
A
D
D
E
V
F
F
V
A
A
S
N
H
-
I
R
S
V
------------------------------------
M
S
E
L
-------------------------------
Q
-
R
----
L
E
K
P
Y
R
R
I
M
I
V
G
G
-------
G
N
I
------
G
A
S
L
A
K
R
L
------
E
Q
T
------
Y
S
-
V
K
L
I
E
R
D
Y
Q
R
A
E
K
L
S
--
E
--
Q
L
E
N
T
I
V
F
C
G
D
A
A
D
Q
E
L
L
T
E
E
N
I
D
Q
V
D
V
F
I
A
L
T
N
E
D
E
T
N
I
M
S
A
M
L
A
K
R
-
M
G
--------
A
K
K
V
M
V
-
L
I
Q
R
G
A
Y
V
D
L
V
Q
G
G
V
-----------------
I
D
V
A
I
S
P
Q
Q
A
T
I
S
A
L
---------
L
T
H
V
R
---
R
A
D
I
V
N
V
S
S
-
L
R
R
G
A
-
A
E
A
-
I
E
----------------------------
A
V
A
H
G
D
E
---
T
T
S
K
V
V
G
R
A
I
G
D
I
K
--
L
--
P
--
P
G
--
T
T
I
G
A
V
V
R
----------------------------
G
E
E
V
L
I
A
H
D
R
T
V
I
E
Q
D
D
H
V
V
M
F
L
V
D
K
K
Y
V
-------------------------
22
PsiBlast_CBE
60.73
38%
-113
- C2 -
1LSS
2
TRKA_METJA
C:
[5-136]
---
M
Y
I
I
I
A
G
I
G
R
V
--
G
Y
--
T
L
A
K
S
L
S
E
K
-----
G
H
-----
D
I
V
L
I
D
I
D
K
D
--
I
C
K
K
-
A
S
-
A
E
I
D
----
A
L
V
I
N
G
D
C
T
K
I
K
T
L
E
D
A
G
I
E
D
A
D
M
Y
I
A
V
T
G
K
--------
E
E
V
N
L
-
M
S
S
L
L
A
K
S
-
Y
-
G
I
-
N
K
T
I
A
R
I
S
E
I
E
Y
---
K
D
V
F
E
R
----
L
------
G
V
D
---
V
V
V
S
P
E
L
I
A
A
N
Y
I
E
K
L
I
E
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.19
38%
-111
- C2 -
1LSS
2
TRKA_METJA
D:
[5-136]
---
M
Y
I
I
I
A
G
I
G
R
V
--
G
Y
--
T
L
A
K
S
L
S
E
K
-----
G
H
-----
D
I
V
L
I
D
I
D
K
D
--
I
C
K
K
-
A
S
-
A
E
I
D
----
A
L
V
I
N
G
D
C
T
K
I
K
T
L
E
D
A
G
I
E
D
A
D
M
Y
I
A
V
T
G
K
--------
E
E
V
N
L
-
M
S
S
L
L
A
K
S
-
Y
-
G
I
-
N
K
T
I
A
R
I
S
E
I
E
Y
---
K
D
V
F
E
R
----
L
------
G
V
D
---
V
V
V
S
P
E
L
I
A
A
N
Y
I
E
K
L
I
E
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
60.04
38%
-113
* C2 *
1LSS
2
TRKA_METJA
B:
[5-136]
---
M
Y
I
I
I
A
G
I
G
R
V
--
G
Y
--
T
L
A
K
S
L
S
E
K
-----
G
H
-----
D
I
V
L
I
D
I
D
K
D
--
I
C
K
K
-
A
S
-
A
E
I
D
----
A
L
V
I
N
G
D
C
T
K
I
K
T
L
E
D
A
G
I
E
D
A
D
M
Y
I
A
V
T
G
K
--------
E
E
V
N
L
-
M
S
S
L
L
A
K
S
-
Y
-
G
I
-
N
K
T
I
A
R
I
S
E
I
E
Y
---
K
D
V
F
E
R
----
L
------
G
V
D
---
V
V
V
S
P
E
L
I
A
A
N
Y
I
E
K
L
I
E
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.36
38%
-104
- C2 -
1LSS
3
TRKA_METJA
A:
[5-136]
---
M
Y
I
I
I
A
G
I
G
R
V
--
G
Y
--
T
L
A
K
S
L
S
E
K
-----
G
H
-----
D
I
V
L
I
D
I
D
K
D
--
I
C
K
K
-
A
S
-
A
E
I
D
----
A
L
V
I
N
G
D
C
T
K
I
K
T
L
E
D
A
G
I
E
D
A
D
M
Y
I
A
V
T
G
K
--------
E
E
V
N
L
-
M
S
S
L
L
A
K
S
-
Y
-
G
I
-
N
K
T
I
A
R
I
S
E
I
E
Y
---
K
D
V
F
E
R
----
L
------
G
V
D
---
V
V
V
S
P
E
L
I
A
A
N
Y
I
E
K
L
I
E
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
58.47
26%
-96
- C2 -
3L4B
-
?
C:
[1-216]
---
M
K
V
I
I
I
G
G
E
T
T
--
A
Y
--
Y
L
A
R
S
M
L
S
R
-----
K
Y
-----
G
V
V
I
I
N
K
D
R
E
--
L
C
E
E
-
F
A
-
K
K
L
K
----
A
T
I
I
H
G
D
G
S
H
K
E
I
L
R
D
A
E
V
S
K
N
D
V
V
V
I
L
T
P
R
--------
D
E
V
N
L
-
F
I
A
Q
L
V
M
K
D
F
-
G
V
-
K
R
V
V
S
L
V
N
D
P
G
N
---
M
E
I
F
K
K
M
----------
G
I
T
---
T
V
L
N
L
T
T
L
I
T
N
T
V
E
A
L
I
F
---
P
D
E
F
-
S
S
I
I
-
P
L
---------
E
-------------------
Q
G
-----
I
E
F
L
S
V
N
V
E
E
D
S
P
V
V
G
K
---------
K
L
K
D
L
P
L
---
P
-
R
---
D
S
--
I
I
A
A
I
V
R
G
G
V
-
L
-
V
V
P
R
G
D
T
E
I
L
S
G
D
K
L
Y
--
V
I
V
S
A
-
E
A
K
E
------------------------------------
T
V
E
E
-------------------------------
T
-
L
----
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
58.38
26%
-101
- C2 -
3L4B
-
?
C:
[1-215]
---
M
K
V
I
I
I
G
G
E
T
T
--
A
Y
--
Y
L
A
R
S
M
L
S
R
-----
K
Y
-----
G
V
V
I
I
N
K
D
R
E
--
L
C
E
E
-
F
A
-
K
K
L
K
----
A
T
I
I
H
G
D
G
S
H
K
E
I
L
R
D
A
E
V
S
K
N
D
V
V
V
I
L
T
P
R
--------
D
E
V
N
L
-
F
I
A
Q
L
V
M
K
-
D
F
G
V
-
K
R
V
V
S
L
V
N
D
P
G
N
---
M
E
I
----
F
K
K
M
------
G
I
T
---
T
V
L
N
L
T
T
L
I
T
N
T
V
E
A
L
I
F
---
P
D
E
F
-
S
S
I
I
-
P
L
---------
E
--------------------
Q
----
G
I
E
F
L
S
V
N
V
E
E
D
S
P
V
V
G
K
---------
K
L
K
D
L
P
L
----
P
R
---
D
S
--
I
I
A
A
I
V
R
G
G
V
-
L
-
V
V
P
R
G
D
T
E
I
L
S
G
D
K
L
Y
--
V
I
V
S
A
-
E
A
K
E
------------------------------------
T
V
E
E
-------------------------------
T
-
L
----
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
58.01
14%
-88
- C2 -
3MT5
2
KCMA1_HUMAN
A:
[4-717]
---
K
H
I
V
V
C
G
H
I
T
L
E
S
V
S
--
N
F
L
K
D
F
L
H
K
DRDDV
N
V
-----
E
I
V
F
L
H
N
I
S
P
NL
E
L
E
A
L
F
K
R
H
F
T
Q
----
V
E
F
Y
Q
G
S
V
L
N
P
H
D
L
A
R
V
K
I
E
S
A
D
A
C
L
I
L
A
N
K
YCAD
P
D
A
E
D
A
S
N
I
-
M
R
V
I
S
I
K
N
-
Y
-
H
P
K
I
R
I
I
T
Q
M
L
Q
Y
H
N
---
K
A
H
----
L
L
N
I
PSWNWK
E
G
D
---
D
A
I
C
L
A
E
L
K
L
G
F
I
A
Q
S
C
L
---
A
Q
G
L
-
S
T
M
L
-
A
N
L
--------
F
S
M
R
S
F
IKIEEDT
W
Q
K
Y
Y
L
E
G
V
----
S
N
E
M
Y
T
E
Y
L
S
S
--
A
F
V
G
L
---------
S
F
P
T
V
C
E
L
C
F
V
K
L
---
K
L
--
L
M
I
A
I
E
Y
-
S
R
I
L
-
I
N
P
G
N
H
L
K
I
Q
E
G
T
L
G
F
--
F
I
A
S
D
A
K
E
V
K
------------------------------------
R
A
F
F
YCKD
N
M
D
S
N
VKKYDSTGM
F
H
W
C
A
PKEIEKVI
L
T
R
S
E
A
A
M
T
V
L
S
G
H
V
V
V
C
I
F
-------
G
D
V
SSALIG
L
R
N
L
V
M
P
L
------
R
A
S
NFHYHE
L
K
H
I
V
F
V
G
S
I
E
Y
L
K
R
E
W
E
TL
H
--
N
F
P
K
V
S
I
L
P
G
T
P
L
S
R
A
D
L
R
A
V
N
I
N
L
C
D
M
C
V
I
L
S
A
N
D
K
E
C
I
L
A
S
L
N
I
K
S
-
M
Q
FDSITTGV
N
I
P
I
I
T
-
E
L
V
N
D
T
N
V
Q
F
L
D
Q
D
D
D
D
D
PD------------
T
E
L
Y
L
T
Q
P
F
A
C
G
T
A
F
AVSVL
D
S
L
M
S
A
T
Y
F
N
D
------
N
I
L
T
L
I
R
T
L
V
-
T
G
G
A--L
E
A
L
I
A
E
EN
A
L
R
G
G
Y
ST
P
Q
T
L
A
N
R
D
R
C
R
V
A
Q
L
A
L
L
DGP
F
A
D
L
G
D
G
G
C
Y
G
D
L
F
C
K
A
--
L
K
T
Y
N
--
M
L
C
F
G
I
Y
R
L
R
DAPSQCT
K
R
Y
V
I
-
T
--------
N
-
P
P
Y
E
F
E
L
V
P
T
D
L
I
F
C
L
M
Q
-
F
D
-----------------------------------
47
HHSearch
57.22
39%
-89
- C2 -
1LSS
3
TRKA_METJA
A:
[5-136]
---
M
Y
I
I
I
A
G
I
G
R
V
--
G
Y
--
T
L
A
K
S
L
S
E
K
-----
G
H
-----
D
I
V
L
I
D
I
D
K
D
--
I
C
K
K
-
A
S
-
A
E
I
D
----
A
L
V
I
N
G
D
C
T
K
I
K
T
L
E
D
A
G
I
E
D
A
D
M
Y
I
A
V
T
G
K
--------
E
E
V
N
L
-
M
S
S
L
L
A
K
S
-
Y
-
G
I
-
N
K
T
I
A
R
I
S
E
I
E
Y
---
K
D
V
----
F
E
R
L
------
G
V
D
---
V
V
V
S
P
E
L
I
A
A
N
Y
I
E
K
L
I
E
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.28
29%
-106
- C2 -
3L4B
-
?
C:
[1-201]
---
M
K
V
I
I
I
G
G
E
T
T
--
A
Y
--
Y
L
A
R
S
M
L
S
R
-----
K
Y
-----
G
V
V
I
I
N
K
D
R
E
--
L
C
E
E
-
F
A
-
K
K
L
K
----
A
T
I
I
H
G
D
G
S
H
K
E
I
L
R
D
A
E
V
S
K
N
D
V
V
V
I
L
T
P
R
--------
D
E
V
N
L
F
I
A
Q
L
V
M
K
D
-
F
-
G
V
-
K
R
V
V
S
L
V
N
D
P
G
N
---
M
E
I
F
K
K
----
M
------
G
I
T
---
T
V
L
N
----
L
T
T
L
I
T
N
T
V
E
ALI
F
P
D
E
F
S
S
I
I
-
P
L
---------
E
-------------------
Q
G
IEFL
S
V
N
V
E
E
D
S
P
V
V
G
K
K
L
K
D
L
---------
P
L
P
R
------------
D
S
--
I
I
A
A
I
V
R
G
G
V
-
L
-
V
V
P
R
G
D
T
E
I
L
S
G
D
K
L
Y
--
V
I
V
S
A
-
E
A
K
E
------------------------------------
T
V
E
E
-------------------------------
T
-
L
----
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
53.62
13%
-76
- C2 -
3MT5
2
KCMA1_HUMAN
A:
[4-717]
---
K
H
I
V
V
C
G
H
I
T
L
--
E
S
V
S
N
F
L
K
D
F
L
H
K
-----
D
R
DDVNV
E
I
V
F
L
H
N
I
S
P
--
N
L
E
L
-
E
A
-
L
F
K
R
H
F
TQ
V
E
F
Y
Q
G
S
V
L
N
P
H
D
L
A
R
V
K
I
E
S
A
D
A
C
L
I
L
A
N
K
YCAD
P
D
A
E
D
A
S
N
I
-
M
R
V
I
S
I
K
N
-
Y
-
H
P
-
K
I
R
I
I
T
Q
M
L
Q
Y
H
---
N
K
A
H
L
L
N
I
P
S
W
------
N
W
K
E
G
D
D
A
I
C
L
A
E
L
K
L
G
F
I
A
Q
S
C
L
---
A
Q
G
L
-
S
T
M
L
-
A
N
L
F
S
M
R
S
F
IK
I
-------------------
E
E
----
D
T
W
Q
K
Y
Y
L
E
G
V
S
N
E
M
Y
T
E
Y
L
S
SAFVGL
S
F
P
T
V
C
E
---
L
C
F
V
KL
K
L
--
L
M
I
A
I
E
Y
S
R
I
-
L
-
I
N
P
G
N
H
L
K
I
Q
E
G
T
L
G
F
--
F
I
A
S
D
-
A
K
E
V
K
RAFFYCKD
N
M
D
S
N
VKKYDSTGM
F
H
W
C
A
PKEIEKVI
L
T
R
S
-------------------------------
E
-
A
----
A
M
T
V
L
S
G
H
V
V
V
C
I
F
G
D
VSSA
L
I
G
------
L
R
N
L
V
M
P
L
R
ASNFH
Y
H
E
------
L
K
H
I
V
F
V
G
S
I
E
Y
L
K
R
E
W
E
--
T
LH
N
F
P
K
V
S
I
L
P
G
T
P
L
S
R
A
D
L
R
A
V
N
I
N
L
C
D
M
C
V
I
L
S
A
N
D
K
E
C
I
L
A
S
L
N
I
K
S
-
M
Q
--------
F
D
S
I
T
T
-
G
V
N
I
P
I
I
T
E
L
V
N
D
T
N
VQFLDQD
D
D
D
D
PDTELY
L
T
Q
P
F
A
C
G
T
A
F
A
V
S
V
---------
L
D
S
L
M
S
A
T
Y
F
N
D
N
I
L
T
L
-
I
R
T
L
V
-
T
G
G
-
A
L
----------------------------
E
A
L
I
A
E
E
---
N
A
L
R
G
G
Y
S
T
P
Q
T
L
A
--
N
--
R
--
D
R
--
C
R
V
A
Q
L
A
L
L
D
----------
G
P
-
F
ADLGDGGC
Y
-
G
D
L
F
C
K
A
L
K
T
Y
N
M
L
C
F
G
I
Y
R
L
R
D
A
P
S
Q
C
T
K
R
Y
V
I
T
NPPYEFELVPT
D
L
I
F
C
L
M
Q
F
D
41
HHSearch
53.60
19%
-99
- C2 -
2AEF
1
MTHK_METTH
A:
[10-228]
---
R
H
V
V
I
C
G
W
S
E
S
--
T
L
--
E
C
L
R
E
L
R
-------
G
S
-----
E
V
F
V
L
A
E
D
E
N
--
V
R
K
K
-
V
L
-
R
S
-
G
----
A
N
F
V
H
G
D
P
T
R
V
S
D
L
E
K
A
N
V
R
G
A
R
A
V
I
V
D
L
E
S
--------
D
S
E
T
I
-
H
C
I
L
G
I
R
K
-
I
-
D
E
S
V
R
I
I
A
E
A
E
R
Y
E
N
---
I
E
Q
----
L
R
M
A
------
G
A
D
---
Q
V
I
S
P
F
V
I
S
G
R
L
M
S
R
S
I
D
---
D
G
Y
E
-
A
M
F
V
Q
D
V
---------
L
A------------------------
T
R
R
M
V
E
V
P
I
P
E
G
S
K
L
E
G
V
---------
S
V
L
D
A
D
I
H
--
D
V
T
---
G
V
--
I
I
I
G
V
G
R
G
D
E
-
L
I
I
D
P
P
R
D
Y
S
F
R
A
G
D
I
I
L
--
G
I
G
K
P
-
E
E
I
E
------------------------------------
R
L
K
N
-------------------------------
Y
-
I
----
S
A
L
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
52.21
24%
-85
- C2 -
3L4B
-
?
C:
[1-216]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
I
I
I
G
G
-------
E
T
T
------
A
Y
Y
L
A
R
S
M
------
L
S
R
------
K
Y
G
V
V
I
I
N
K
D
R
E
L
C
E
E
F
A
--
K
--
K
L
-
K
A
T
I
I
H
G
D
G
S
H
K
E
I
L
R
D
A
E
V
S
K
N
D
V
V
V
I
L
T
P
R
D
E
V
N
L
F
I
A
Q
L
V
M
K
D
F
G
--------
V
K
R
V
V
S
-
L
V
N
D
P
G
N
M
E
I
F
K
K
M
G
-----------------
I
T
T
V
L
N
L
T
T
L
I
T
N
T
V
---------
E
A
L
I
F
P
D
------
E
F
S
S
-
I
I
P
L
--
E
Q
G
-
I
E
----------------------------
F
L
S
V
N
V
E
---
E
D
S
P
V
V
G
K
K
L
K
D
L
P
--
L
--
P
--
R
D
--
S
I
I
A
A
I
V
R
G
G
----------
V
L
-
V
--------
V
-
P
R
G
D
T
E
I
L
S
G
D
K
L
Y
V
I
V
S
A
E
A
K
E
T
V
E
E
T
L
L
--------------------------
44
HHSearch
52.19
19%
-93
- C2 -
1LNQ
1
MTHK_METTH
A:
[116-334]
---
R
H
V
V
I
C
G
W
S
E
S
--
T
L
--
E
C
L
R
E
L
R
-------
G
S
-----
E
V
F
V
L
A
E
D
E
N
--
V
R
K
K
-
V
L
-
R
S
-
G
----
A
N
F
V
H
G
D
P
T
R
V
S
D
L
E
K
A
N
V
R
G
A
R
A
V
I
V
D
L
E
S
--------
D
S
E
T
I
-
H
C
I
L
G
I
R
K
-
I
-
D
E
S
V
R
I
I
A
E
A
E
R
Y
E
N
---
I
E
Q
----
L
R
M
A
------
G
A
D
---
Q
V
I
S
P
F
V
I
S
G
R
L
M
S
R
S
I
D
---
D
G
Y
E
-
A
M
F
V
-
Q
D
V
L
A------
E
-------------------
E
S
----
T
R
R
M
V
E
V
P
I
P
E
G
S
K
L
E
G
V
---------
S
V
L
D
A
D
I
H--
D
V
T
---
G
V
--
I
I
I
G
V
G
R
G
D
E
-
L
I
I
D
P
P
R
D
Y
S
F
R
A
G
D
I
I
L
--
G
I
G
K
P
-
E
E
I
E
------------------------------------
R
L
K
N
-------------------------------
Y
-
I
----
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
50.86
18%
-86
- C2 -
2AEF
1
MTHK_METTH
A:
[10-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
V
I
C
G
W
-------
S
E
S
------
T
L
E
C
L
R
E
L
------
R
--------
G
S
E
V
F
V
L
A
E
D
E
N
V
R
K
K
V
L
--
R
--
S
--
G
A
N
F
V
H
G
D
P
T
R
V
S
D
L
E
K
A
N
V
R
G
A
R
A
V
I
V
D
L
E
S
D
S
E
T
I
H
C
I
L
G
I
R
K
-
I
D
E-------
S
V
R
I
I
A
-
E
A
E
R
Y
E
N
I
E
Q
L
R
M
A
G
-----------------
A
D
Q
V
I
S
P
F
V
I
S
G
R
L
M
---------
S
R
S
I
D
D
G
------
Y
E
A
M
F
V
Q
D
V
L
A--
T
-
R
R
----------------------------
M
V
E
V
P
I
P
---
E
G
S
K
L
E
G
V
S
V
L
D
A
D
--
I
H
D
V
--
T
G
--
V
I
I
I
G
V
G
R
G
D
----------
E
L
I
I
--------
D
-
P
P
R
D
Y
S
F
R
A
G
D
I
I
L
G
I
G
K
P
E
E
I
E
R
L
K
N
Y
I
S
A
-------------------------
60
Fugue
50.53
20%
-91
- C2 -
2G1U
4
?
A:
[17-151]
QK
S
K
Y
I
V
I
F
G
C
G
R
L
--
G
S
--
L
I
A
N
L
A
S
S
S
-----
G
H
-----
S
V
V
V
V
D
K
N
E
Y
--
A
F
H
R
-
L
N
-
S
E
F
S
----
G
F
T
V
V
G
D
A
A
E
F
E
T
L
K
E
C
G
M
E
K
A
D
M
V
F
A
F
T
N
D
--------
D
S
T
N
F
-
F
I
S
M
N
A
R
Y
-
M
F
N
V
-
E
N
V
I
A
R
V
Y
D
P
E
K
---
I
K
I
F
E
E
N
G
-----------
I
---
K
T
I
C
P
A
V
L
M
I
E
K
V
K
E
F
I
I
---
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
48.86
16%
-73
- C2 -
1LNQ
1
MTHK_METTH
A:
[19-336]
------------------------------------------------------------------------------------------------------------
P
A
T
R
I
-
L
L
L
V
L
A
V
I
-
I
-
Y
G
-
T
A
G
F
H
F
I
E
G
E
S
W
---
T
V
S
--------------------------
L
Y
W
T
F
V
T
I
A
T
V
G
---
Y
G
D
Y
-
S
P
S
T
--------------------------------
P
L
----
G
M
Y
F
T
V
T
L
I
V
L
G
I
G
T
F
A
V
---------
A
V
E
R
L
L
E
---
F
L
R
---
H
V
--
V
I
C
-------------------------------------------------------------------------------------------------------------------------------
G
W
-------
S
E
S
------
T
L
E
C
L
R
E
L
------
R
G
S
------
E
--
V
F
V
L
A
E
D
E
N
V
R
K
K
V
L
--
R
----
S
G
A
N
F
V
H
G
D
P
T
R
V
S
D
L
E
K
A
N
V
R
G
A
R
A
V
I
V
D
L
E
S
D
S
E
T
I
H
C
I
L
G
I
R
K
-
I
D
--------
E
S
V
R
I
I
A
E
A
E
R
Y
E
N
I
E
Q
L
R
M
A
G
-----------------
A
D
Q
V
I
S
P
F
V
I
S
G
R
L
M
---------
S
R
S
I
---
D
D
G
Y
E
A
M
F
V
Q
-
D
V
L
A
E
-
E
S
T
-
R
R
----------------------------
M
V
E
V
P
I
P
---
E
G
S
K
L
E
G
V
S
V
L
D
A
D
--
I
--
H
--
D
V
TG
V
I
I
I
G
V
G
R
G
D
----------
E
L
-
I
--------
I
D
P
P
R
D
Y
S
F
R
A
G
D
I
I
L
G
I
G
K
P
E
E
I
E
R
L
K
N
Y
I
S
A
-------------------------
52
HHSearch
48.72
21%
-73
- C2 -
1LSS
3
TRKA_METJA
A:
[5-136]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Y
I
I
I
A
G
I
-------
G
R
V
------
G
Y
T
L
A
K
S
L
------
S
E
K
------
G
H
D
I
V
L
I
D
I
D
K
D
I
C
K
K
A
S
--
A
--
E
I
-
D
A
L
V
I
N
G
D
C
T
K
I
K
T
L
E
D
A
G
I
E
D
A
D
M
Y
I
A
V
T
G
K
E
E
V
N
L
M
S
S
L
L
A
K
S
-
Y
G
--------
I
N
K
T
I
A
-
R
I
S
E
I
E
Y
K
D
V
F
E
R
L
G
-----------------
V
D
V
V
V
S
P
E
L
I
A
A
N
Y
I
---------
E
K
L
I
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------