@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1659: (2015-12-09 )
MKKTILLGLVGLSAMTLAACSNGQSSKETTWDNIKKDGVLKVATPATLYPTSYYDDHKKLTGYEIDMMKAIAKKLKIKVKFVEVGVAESFTSVDSGKVDVAVNNFDTTPERLKKYNFSQPYKYSVGGMIVRADGSSKITAKDLSDWKGKKAGGGAGTQYMKIAKQQGAEPVIYDNVTNDVYLRDVSTGRTDFIPNDYYTQVIAVKYVTKQYPDIKVKMGDVKYNPTEQGIVMSKKDKSLKTKIDAAIKDMKKDGSLKKISEKYYAGQDLTKEPAGTDKIPVIKVK
Atome Classification :
(20 SA)
.........10........20........30........40........50.......------.60........70....---.---...80...-.....90........100....-.-..110.--......120.......130.......140.......150.......-160.----...----.-..----170.......---180.......190.......200.....-..210---...--...---.-..----220----.......----.----230.......240.......250.......260.......270.......280...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
T
I
L
L
G
L
V
G
L
S
A
M
T
L
A
ACSNGQSSKET
T
W
DNIKKD
G
V
L
K
VATP
A
T
L
YPTSYYDDHK------KLTG
Y
E
I
D
M
M
K
A
I
A
K
K
L
---
K
---
I
K
V
K
F
V
E
V-GV
A
E
S
FTSVDSG
K
V
D
V
A
VNNFD-T-
T
P
E
R
L
K
--KYNFSQ
P
Y
K
YSV
G
G
M
I
V
RADGSS
K
I
T
A
K
D
L
S
DWKGKKAGGGAG
T
Q
Y
-
M
K
I
A
----
K
QQ----G-AE----
P
V
I
YDNVTN
D
---
V
Y
L
R
DVSTGRTDFIPNDY
Y
T
Q
V
I
A
V
K
Y
V
-TKQ-----YP
D
--
I
K
V
---
K
-MG----D-V----KYNPTEQ----
G
----
I
V
MSKKD
K
S
L
K
T
K
I
D
A
A
I
K
D
M
K
KDG
S
L
K
K
I
S
E
K
YYAGQDLTKEPAGTDK
I
P
V
I
K
VK
9
PsiBlast_PDB
82.15
27%
-52
- C3 -
2Y7I
7
?
A:
[8-227]
---------------------------------------
L
H
F
G
T
S
A
T
Y
A
P
Y
E
F
V
D
A
D
N
------
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
---
Q
---
A
E
C
S
F
T
N
Q
-
S
F
D
S
L
I
P
S
L
R
F
K
K
F
D
A
V
I
A
G
M
D
-
M
-
T
P
K
R
E
Q
--
Q
V
S
F
S
Q
P
Y
Y
E
G
L
S
A
V
V
V
T
R
K
G
A
Y
H
T
----
F
A
D
L
K
G
K
K
V
G
L
E
N
G
T
T
H
-
Q
R
Y
L
Q
D
--
K
Q
Q
----
A
-
I
T
----
P
V
A
Y
D
S
Y
L
N
A
-----
F
T
D
L
K
N
N
R
L
E
G
V
F
G
D
----
V
A
A
I
G
K
W
-
L
K
N
-----
N
P
D
--
Y
A
I
MD
E
R
-
A
S
----
D
-
P
----
D
Y
Y
G
K
G
L
----
G
----
I
A
V
R
K
D
N
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
K
A
S
P
E
Y
A
Q
M
Q
E
K
W
F
T
--------------------
2
PsiBlast_PDB
81.66
31%
-59
- C3 -
2YLN
10
?
A:
[51-281]
-------------------------------
E
R
I
N
N
K
G
T
V
T
V
G
T
E
G
T
Y
A
P
F
T
Y
H
D
K
D
G
------
K
L
T
G
Y
D
V
E
V
T
R
A
V
A
E
K
L
---
G
---
V
K
V
E
F
K
E
T
-
Q
W
D
S
M
M
A
G
L
K
A
G
R
F
D
V
V
A
N
Q
V
G
L
T
-
S
P
E
R
Q
A
--
T
F
D
K
S
E
P
Y
S
W
S
--
G
A
V
L
V
A
H
N
D
S
N
I
--
K
S
I
A
D
I
K
G
V
K
T
A
Q
S
L
T
S
N
Y
-
G
E
K
A
----
K
A
A
----
G
-
A
Q
----
L
V
P
V
D
G
L
A
Q
S
---
L
T
L
--
I
E
Q
K
R
A
D
A
T
L
N
D
E
----
L
A
V
L
D
Y
-
L
K
K
-----
N
P
N
--
A
G
V
---
K
-
I
-------
V
----
W
S
A
P
A
D
E
K
V
G
S
G
----
L
I
V
N
K
G
N
D
E
A
V
A
K
F
S
T
A
I
N
E
L
K
A
D
G
T
L
K
K
L
G
E
Q
F
F
-
G
K
D
I
S
V
Q
-------------
35
HHSearch
80.60
26%
-47
- C3 -
2Y7I
7
?
A:
[3-228]
----------------------------------
V
S
A
R
T
L
H
F
G
T
S
A
T
Y
A
P
Y
E
F
V
D
A
D
N
------
K
I
V
G
F
D
I
D
V
A
N
A
V
C
K
E
M
---
Q
---
A
E
C
S
F
T
N
Q
-
S
F
D
S
L
I
P
S
L
R
F
K
K
F
D
A
V
I
A
G
M
D
-
M
-
T
P
K
R
E
Q
--
Q
V
S
F
S
Q
P
Y
Y
E
G
L
S
A
V
V
V
T
R
K
--
G
A
Y
--
H
T
F
A
D
L
K
G
K
K
V
G
L
E
N
G
T
T
H
-
Q
R
Y
L
----
Q
D
K
Q---
Q
A
I
T
----
P
V
A
Y
D
S
--
Y
L
---
N
A
F
T
D
L
K
N
N
R
L
E
G
V
F
G
D
V
A
A
----
I
G
K
W
-
L
K
N
-----
N
P
D
--
Y
A
I
-----
M
D
E
R
A
S
D
-
P
----
D
Y
Y
G
K
G
L
----
G
----
I
A
V
R
K
D
N
D
A
L
L
Q
E
I
N
A
A
L
D
K
V
K
A
S
P
E
Y
A
Q
M
Q
E
K
W
F
T
--------------------
3
PsiBlast_PDB
79.95
31%
-59
- C3 -
3ZSF
-
?
A:
[43-273]
-------------------------------
E
R
I
N
N
K
G
T
V
T
V
G
T
E
G
T
Y
A
P
F
T
Y
H
D
K
D
G
------
K
L
T
G
Y
D
V
E
V
T
R
A
V
A
E
K
L
---
G
---
V
K
V
E
F
K
E
T
-
Q
W
D
S
M
M
A
G
L
K
A
G
R
F
D
V
V
A
N
Q
V
G
L
T
-
S
P
E
R
Q
A
--
T
F
D
K
S
E
P
Y
S
W
S
--
G
A
V
L
V
A
H
N
D
S
N
I
--
K
S
I
A
D
I
K
G
V
K
T
A
Q
S
L
T
S
N
Y
-
G
E
K
A
----
K
A
A
----
G
-
A
Q
----
L
V
P
V
D
G
L
A
Q
S
---
L
T
L
--
I
E
Q
K
R
A
D
A
T
L
N
D
E
----
L
A
V
L
D
Y
-
L
K
K
-----
N
P
N
--
A
G
V
---
K
-
I
-------
V
----
W
S
A
P
A
D
E
K
V
G
S
G
----
L
I
V
N
K
G
N
D
E
A
V
A
K
F
S
T
A
I
N
E
L
K
A
D
G
T
L
K
K
L
G
E
Q
F
F
-
G
K
D
I
S
V
Q
-------------
10
PsiBlast_PDB
79.70
29%
-63
- C3 -
4YMX
1
?
A:
[37-258]
-------------------------------------
G
V
I
V
M
G
T
S
A
D
F
P
P
F
E
F
---
H
K
VEGGKD
E
I
V
G
F
D
I
D
I
A
N
A
I
A
K
K
L
---
G
---
V
K
L
E
I
K
D
M
-
D
F
K
G
L
I
P
A
L
Q
A
G
R
V
D
M
V
I
A
G
M
T
-
P
-
T
A
E
R
K
K
--
S
V
D
F
S
D
L
Y
Y
D
S
R
Q
V
V
V
V
K
N
D
--
S
P
I
S
K
F
D
--
D
L
K
V
K
T
I
A
V
Q
I
G
T
T
S
-
E
E
A
A
----
K
K
I
----
P
-
N
V
----
K
L
K
Q
L
N
R
V
S
D
---
E
F
M
-
D
L
Q
N
G
R
C
D
A
I
---
V
V
E
D
T
V
A
K
A
Y
L
--
K
E
-----
Y
K
D
--
M
K
I
---
L
-
Y
M
----
D
------
E
I
N
N
V
E
N
----
G
S
A
--
V
A
V
A
K
G
N
K
S
L
L
D
V
V
N
E
V
I
K
E
L
K
Q
S
G
E
Y
D
K
L
V
D
K
W
F
K
Q
-------------------
26
HHSearch
77.00
26%
-41
- C3 -
2YJP
10
?
A:
[45-281]
---------------------------
A
A
T
V
A
A
I
K
E
K
G
V
I
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
A
N
G
------
K
N
Q
G
F
D
V
E
I
A
K
D
L
A
K
D
L
LGS
P
---
D
K
V
E
F
V
L
T
-
E
A
A
N
R
V
E
Y
V
R
S
G
K
V
D
L
I
L
A
N
F
T
-
Q
-
T
P
E
R
A
E
--
A
V
D
F
A
D
P
Y
M
K
V
A
L
G
V
V
S
P
K
N
--
K
P
I
--
T
D
M
A
Q
L
K
D
Q
T
L
L
V
N
K
G
T
T
A
-
D
A
F
F
----
T
K
S
H---
P
E
V
K
----
L
L
K
F
D
Q
--
N
T
---
E
T
F
D
A
L
K
D
G
R
G
V
A
L
A
H
D
N
A
L
----
L
W
A
W
-
A
K
E
-----
N
P
N
--
F
E
V
-----
A
I
----
G
-
N
----
L
G
P
A
E
F
I
----
A
----
P
A
V
Q
K
G
N
A
D
L
L
N
W
V
N
G
E
I
A
A
M
K
K
D
G
R
L
K
A
A
Y
E
K
T
L
L
P
-
V
Y
G
E
K
V
K
P
E
A
L
L
A
E
----
27
HHSearch
76.37
29%
-46
- C3 -
1XT8
1
?
A:
[34-266]
---------------------------
L
N
S
L
D
K
I
K
Q
N
G
V
V
R
I
G
V
F
G
D
K
P
P
F
G
Y
V
D
E
K
G
------
N
N
Q
G
Y
D
I
A
L
A
K
R
I
A
K
E
L
---
F
GDE
N
K
V
Q
F
V
L
V
-
E
A
A
N
R
V
E
F
L
K
S
N
K
V
D
I
I
L
A
N
F
T
-
Q
-
T
P
Q
R
A
E
--
Q
V
D
F
C
S
P
Y
M
K
V
A
L
G
V
A
V
P
K
D
--
S
N
I
--
T
S
V
E
D
L
K
D
K
T
L
L
L
N
K
G
T
T
A
-
D
A
Y
F
----
T
Q
N
Y---
P
N
I
K
----
T
L
K
Y
D
Q
--
N
T
---
E
T
F
A
A
L
M
D
K
R
G
D
A
L
S
H
D
N
T
L
----
L
F
A
W
-
V
K
D
-----
H
P
D
--
F
K
M
-----
G
I
----
K
-
E
----
L
G
N
K
D
V
I
----
A
----
P
A
V
K
K
G
D
K
E
L
K
E
F
I
D
N
L
I
I
K
L
G
Q
E
Q
F
F
H
K
A
Y
D
E
T
L
K
A
H
F
G
D
D
V
K
A
D
D
V
V
I
E
G
----
19
PsiBlast_PDB
74.75
25%
-44
- C3 -
1LAG
1
ARGT_SALTY
E:
[6-231]
---------------------------------------
V
R
I
G
T
D
T
T
Y
A
P
F
S
S
K
D
A
K
G
------
E
F
I
G
F
D
I
D
L
G
N
E
M
C
K
R
M
---
Q
---
V
K
C
T
W
V
A
S
-
D
F
D
A
L
I
P
S
L
K
A
K
K
I
D
A
I
I
S
S
L
S
-
I
-
T
D
K
R
Q
Q
--
E
I
A
F
S
D
K
L
-
Y
A
A
D
S
R
L
I
A
A
K
G
S
P
--
I
Q
P
T
L
E
S
L
K
G
K
H
V
G
V
L
Q
G
S
T
Q
-
E
A
Y
A
NDNW
R
T
K
----
G
-
V
D
----
V
V
A
Y
A
N
--
Q
D
---
L
I
Y
S
D
L
T
A
G
R
L
D
A
A
L
Q
D
---
E
V
A
A
S
E
G
F
-
L
K
Q
PAGKE
Y
A
F
--
A
G
P
---
S
-
V
K
----
D
-
K
----
K
Y
F
G
D
G
T
----
G
----
V
G
L
R
K
D
D
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
D
G
T
Y
D
K
M
A
K
K
Y
F
D
F
N
V
Y
G
D
--------------
5
PsiBlast_PDB
74.55
25%
-34
- C3 -
3VVD
1
?
A:
[21-257]
----------------------
G
S
E
F
Q
V
R
S
F
E
E
I
K
R
S
G
E
I
R
I
G
T
E
G
A
F
P
P
F
N
Y
F
D
E
R
N
------
Q
L
T
G
F
E
V
D
L
G
N
A
I
A
E
R
L
---
G
---
L
K
P
R
W
I
A
Q
-
S
F
D
T
L
L
I
Q
L
N
Q
G
R
F
D
F
V
I
A
S
H
G
-
I
-
T
E
E
R
A
R
--
A
V
D
F
T
N
P
H
-
Y
C
T
G
G
V
I
V
S
R
K
G
G
P
R
-
T
A
K
D
L
---
Q
G
K
V
V
G
V
Q
V
G
T
T
Y
-
M
E
A
A
----
Q
K
I
----
P
-
G
I
----
K
E
V
R
T
Y
Q
R
D
P
---
D
A
L
Q
D
L
L
A
G
R
I
D
T
W
I
T
D
R
F
---
V
A
K
E
A
I
-
K
E
R
-----
K
L
E
--
N
T
L
---
Q
-
V
G
----
E
-
L
----
V
F
Q
-
E
R
V
----
A
----
M
A
V
A
K
G
N
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
D
G
T
Y
A
R
I
S
Q
K
W
F
-
G
E
D
V
R
C
K
-------------
20
PsiBlast_PDB
74.37
25%
-42
- C3 -
1LAH
1
ARGT_SALTY
E:
[6-231]
---------------------------------------
V
R
I
G
T
D
T
T
Y
A
P
F
S
S
K
D
A
K
G
------
E
F
I
G
F
D
I
D
L
G
N
E
M
C
K
R
M
---
Q
---
V
K
C
T
W
V
A
S
-
D
F
D
A
L
I
P
S
L
K
A
K
K
I
D
A
I
I
S
S
L
S
-
I
-
T
D
K
R
Q
Q
--
E
I
A
F
S
D
K
L
-
Y
A
A
D
S
R
L
I
A
A
K
G
S
P
--
I
Q
P
T
L
E
S
L
K
G
K
H
V
G
V
L
Q
G
S
T
Q
-
E
A
Y
A
NDNW
R
T
K
----
G
-
V
D
----
V
V
A
Y
A
N
--
Q
D
---
L
I
Y
S
D
L
T
A
G
R
L
D
A
A
L
Q
D
---
E
V
A
A
S
E
G
F
-
L
K
Q
PAGKE
Y
A
F
--
A
G
P
---
S
-
V
K
----
D
-
K
----
K
Y
F
G
D
G
T
----
G
----
V
G
L
R
K
D
D
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
D
G
T
Y
D
K
M
A
K
K
Y
F
D
F
N
V
Y
G
D
--------------
7
PsiBlast_PDB
74.34
25%
-37
- C3 -
3VVF
3
?
A:
[21-257]
----------------------
G
S
E
F
Q
V
R
S
F
E
E
I
K
R
S
G
E
I
R
I
G
T
E
G
A
F
P
P
F
N
Y
F
D
E
R
N
------
Q
L
T
G
F
E
V
D
L
G
N
A
I
A
E
R
L
---
G
---
L
K
P
R
W
I
A
Q
-
S
F
D
T
L
L
I
Q
L
N
Q
G
R
F
D
F
V
I
A
S
H
G
-
I
-
T
E
E
R
A
R
--
A
V
D
F
T
N
P
H
-
Y
C
T
G
G
V
I
V
S
R
K
G
G
P
R
-
T
A
K
D
L
---
Q
G
K
V
V
G
V
Q
V
G
T
T
Y
-
M
E
A
A
----
Q
K
I
----
P
-
G
I
----
K
E
V
R
T
Y
Q
R
D
P
---
D
A
L
Q
D
L
L
A
G
R
I
D
T
W
I
T
D
R
F
---
V
A
K
E
A
I
-
K
E
R
-----
K
L
E
--
N
T
L
---
Q
-
V
G
----
E
-
L
----
V
F
Q
-
E
R
V
----
A
----
M
A
V
A
K
G
N
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
D
G
T
Y
A
R
I
S
Q
K
W
F
-
G
E
D
V
R
C
K
-------------
6
PsiBlast_PDB
74.13
25%
-39
- C3 -
3VVE
2
?
A:
[21-257]
----------------------
G
S
E
F
Q
V
R
S
F
E
E
I
K
R
S
G
E
I
R
I
G
T
E
G
A
F
P
P
F
N
Y
F
D
E
R
N
------
Q
L
T
G
F
E
V
D
L
G
N
A
I
A
E
R
L
---
G
---
L
K
P
R
W
I
A
Q
-
S
F
D
T
L
L
I
Q
L
N
Q
G
R
F
D
F
V
I
A
S
H
G
-
I
-
T
E
E
R
A
R
--
A
V
D
F
T
N
P
H
-
Y
C
T
G
G
V
I
V
S
R
K
G
G
P
R
-
T
A
K
D
L
---
Q
G
K
V
V
G
V
Q
V
G
T
T
Y
-
M
E
A
A
----
Q
K
I
----
P
-
G
I
----
K
E
V
R
T
Y
Q
R
D
P
---
D
A
L
Q
D
L
L
A
G
R
I
D
T
W
I
T
D
R
F
---
V
A
K
E
A
I
-
K
E
R
-----
K
L
E
--
N
T
L
---
Q
-
V
G
----
E
-
L
----
V
F
Q
-
E
R
V
----
A
----
M
A
V
A
K
G
N
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
D
G
T
Y
A
R
I
S
Q
K
W
F
-
G
E
D
V
R
C
K
-------------
28
HHSearch
74.11
30%
-49
- C3 -
2YLN
10
?
A:
[49-278]
-----------------------------
L
I
E
R
I
N
N
K
G
T
V
T
V
G
T
E
G
T
Y
A
P
F
T
Y
H
D
K
D
G
------
K
L
T
G
Y
D
V
E
V
T
R
A
V
A
E
K
L
---
G
---
V
K
V
E
F
K
E
T
-
Q
W
D
S
M
M
A
G
L
K
A
G
R
F
D
V
V
A
N
Q
V
G
-
L
T
S
P
E
R
Q
A
--
T
F
D
K
S
E
P
Y
S
W
S
G
A
V
L
V
A
H
N
D
--
S
N
I
--
K
S
I
A
D
I
K
G
V
K
T
A
Q
S
L
T
S
N
Y
-
G
E
K
A
----
K
A
A
----
G
-
A
Q
----
L
V
P
V
D
G
--
L
A
---
Q
S
L
T
L
I
E
Q
K
R
A
D
A
T
L
N
D
E
L
A
----
V
L
D
Y
-
L
K
K
-----
N
P
N
AG
V
K
I
-----
V
W
----
S
A
P
----
A
D
E
K
V
G
S
----
G
----
L
I
V
N
K
G
N
D
E
A
V
A
K
F
S
T
A
I
N
E
L
K
A
D
G
T
L
K
K
L
G
E
Q
F
F
G
K
D
I
S
V
Q
--------------
12
PsiBlast_PDB
73.90
29%
-54
- C3 -
4PSH
1
?
A:
[3-214]
-------------------------------
D
E
I
K
S
R
G
Y
L
L
V
G
L
S
A
D
F
P
P
F
E
F
V
D
E
N
G
------
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
R
L
---
G
---
V
E
L
K
I
V
D
M
-
T
F
D
G
L
I
P
S
L
L
T
K
K
I
D
V
I
I
S
G
M
T
-
I
-
T
E
E
R
K
K
--
V
V
A
F
S
D
P
Y
F
D
A
G
Q
V
I
V
V
R
K
D
--
S
D
F
R
P
K
T
Y
E
D
L
V
G
K
T
V
A
V
Q
I
G
T
T
G
D
I
E
V
S
----
K
Y
D
----
G
-
I
K
----
V
V
R
F
D
K
F
T
-
D
---
A
F
L
-
E
L
K
R
G
R
A
D
A
V
V
L
D
S
A
T
---
A
R
A
F
V
-
A
K
N
------
P
D
--
L
V
I
---
S
-
S
G
-----------
V
L
S
S
E
Q
Y
----
G
----
I
A
V
R
K
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
---------------------
18
PsiBlast_PDB
73.73
25%
-39
- C3 -
1LAF
1
ARGT_SALTY
E:
[6-231]
---------------------------------------
V
R
I
G
T
D
T
T
Y
A
P
F
S
S
K
D
A
K
G
------
E
F
I
G
F
D
I
D
L
G
N
E
M
C
K
R
M
---
Q
---
V
K
C
T
W
V
A
S
-
D
F
D
A
L
I
P
S
L
K
A
K
K
I
D
A
I
I
S
S
L
S
-
I
-
T
D
K
R
Q
Q
--
E
I
A
F
S
D
K
L
-
Y
A
A
D
S
R
L
I
A
A
K
G
S
P
--
I
Q
P
T
L
E
S
L
K
G
K
H
V
G
V
L
Q
G
S
T
Q
-
E
A
Y
A
NDNW
R
T
K
----
G
-
V
D
----
V
V
A
Y
A
N
--
Q
D
---
L
I
Y
S
D
L
T
A
G
R
L
D
A
A
L
Q
D
---
E
V
A
A
S
E
G
F
-
L
K
Q
PAGKE
Y
A
F
--
A
G
P
---
S
-
V
K
----
D
-
K
----
K
Y
F
G
D
G
T
----
G
----
V
G
L
R
K
D
D
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
D
G
T
Y
D
K
M
A
K
K
Y
F
D
F
N
V
Y
G
D
--------------
4
PsiBlast_PDB
73.50
25%
-37
- C3 -
3VV5
1
?
A:
[24-257]
-------------------------
F
Q
V
R
S
F
E
E
I
K
R
S
G
E
I
R
I
G
T
E
G
A
F
P
P
F
N
Y
F
D
E
R
N
------
Q
L
T
G
F
E
V
D
L
G
N
A
I
A
E
R
L
---
G
---
L
K
P
R
W
I
A
Q
-
S
F
D
T
L
L
I
Q
L
N
Q
G
R
F
D
F
V
I
A
S
H
G
-
I
-
T
E
E
R
A
R
--
A
V
D
F
T
N
P
H
-
Y
C
T
G
G
V
I
V
S
R
K
G
G
P
R
-
T
A
K
D
L
---
Q
G
K
V
V
G
V
Q
V
G
T
T
Y
-
M
E
A
A
----
Q
K
I
----
P
-
G
I
----
K
E
V
R
T
Y
Q
R
D
P
---
D
A
L
Q
D
L
L
A
G
R
I
D
T
W
I
T
D
R
F
---
V
A
K
E
A
I
-
K
E
R
-----
K
L
E
--
N
T
L
---
Q
-
V
G
----
E
-
L
----
V
F
Q
-
E
R
V
----
A
----
M
A
V
A
K
G
N
K
S
L
L
D
A
L
N
R
A
L
A
E
L
M
Q
D
G
T
Y
A
R
I
S
Q
K
W
F
-
G
E
D
V
R
C
K
-------------
17
PsiBlast_PDB
72.98
29%
-56
- C3 -
4EQ9
1
?
A:
[12-242]
-----------------------------------------
V
A
T
N
G
S
P
R
P
F
-
I
Y
E
E
N
G
------
E
L
T
G
Y
E
I
E
V
V
R
A
I
F
K
D
S
D--
K
---
Y
D
V
K
F
E
K
T
-
E
W
S
G
V
F
A
G
L
D
A
D
R
Y
N
M
A
V
N
N
L
S
-
Y
-
T
K
E
R
A
E
--
K
Y
L
Y
A
A
P
I
A
Q
N
P
N
V
L
V
V
K
K
D
D
S
S
---
I
K
S
L
D
D
I
G
G
K
S
T
E
V
V
Q
A
T
T
S
-
A
K
Q
L
----
E
A
Y
----
N
-
A
E
H
TDN
P
T
I
L
N
Y
T
K
A
D
F
Q
Q
I
M
V
R
-
L
S
D
G
Q
F
D
Y
K
I
F
D
----
K
I
G
V
E
T
V
-
I
K
N
-----
Q
G
L
--
D
N
L
---
K
-
V
I
----
E
-
L
-------
P
S
D
Q
----
Q
P
Y
V
Y
P
L
L
A
Q
G
Q
D
E
L
K
S
F
V
D
K
R
I
K
E
L
Y
K
D
G
T
L
E
K
L
S
K
Q
F
F
G
D
T
Y
L
P
A
E
A
D
I
K
---------
11
PsiBlast_PDB
71.91
29%
-63
- C3 -
4PRS
-
?
A:
[3-214]
-------------------------------
D
E
I
K
S
R
G
Y
L
L
V
G
L
S
A
D
F
P
P
F
E
F
V
D
E
N
G
------
N
I
V
G
F
D
V
D
L
A
K
E
I
A
R
R
L
---
G
---
V
E
L
K
I
V
D
M
-
T
F
D
G
L
I
P
S
L
L
T
K
K
I
D
V
I
I
S
G
M
T
-
I
-
T
E
E
R
K
K
--
V
V
A
F
S
D
P
Y
F
D
A
G
Q
V
I
V
V
R
K
D
--
S
D
F
R
P
K
T
Y
E
D
L
V
G
K
T
V
A
V
Q
I
G
T
T
G
D
I
E
V
S
----
K
Y
D
----
G
-
I
K
----
V
V
R
F
D
K
F
T
-
D
---
A
F
L
-
E
L
K
R
G
R
A
D
A
V
V
L
D
S
A
T
---
A
R
A
F
V
-
A
K
N
------
P
D
--
L
V
I
---
S
-
S
G
-----------
V
L
S
S
E
Q
Y
----
G
----
I
A
V
R
K
E
D
T
D
L
L
E
F
I
N
S
V
L
R
E
L
K
K
S
P
Y
D
V
L
I
E
K
W
F
S
---------------------
39
HHSearch
71.74
24%
-33
- C3 -
1LST
1
ARGT_SALTY
A:
[2-233]
-----------------------------------
L
P
Q
T
V
R
I
G
T
D
T
T
Y
A
P
F
S
S
K
D
A
K
G
------
E
F
I
G
F
D
I
D
L
G
N
E
M
C
K
R
M
---
Q
---
V
K
C
T
W
V
A
S
-
D
F
D
A
L
I
P
S
L
K
A
K
K
I
D
A
I
I
S
S
L
S
-
I
-
T
D
K
R
Q
Q
--
E
I
A
F
S
D
K
L
Y
A
A
D
S
R
L
I
A
A
K
G
S
-
P
I
Q
--
P
T
L
E
S
L
K
G
K
H
V
G
V
L
Q
G
S
T
Q
-
E
A
Y
A
----
N
D
N
WRTK
G
-
V
D
----
V
V
A
Y
A
N
--
Q
D
---
L
I
Y
S
D
L
T
A
G
R
L
D
A
A
L
Q
D
E
V
A
----
A
S
E
G
F
L
K
Q
-----
P
A
G
KE
Y
A
F
-----
A
G
----
P
-
S
VKDK
K
Y
F
G
D
G
T
----
G
----
V
G
L
R
K
D
D
T
E
L
K
A
A
F
D
K
A
L
T
E
L
R
Q
D
G
T
Y
D
K
M
A
K
K
Y
F
D
F
N
V
Y
G
D
--------------
41
HHSearch
71.56
20%
-57
- C3 -
1II5
1
?
A:
[3-226]
------------------------------------
A
M
A
L
K
V
G
V
-
V
G
N
P
P
F
V
F
Y
G
---------
A
F
T
G
I
S
L
D
V
W
R
A
V
A
E
S
Q
---
K
---
W
N
S
E
Y
V
R
Q
N
S
I
S
A
G
I
T
A
V
A
E
G
E
L
D
I
L
I
G
P
I
S
-
V
-
T
P
E
R
A
A
IE
G
I
T
F
T
Q
P
Y
F
S
S
G
I
G
L
L
I
P
G
T
A
T
P
L
F
--
R
S
V
G
D
L
K
N
K
E
V
A
V
V
R
D
T
T
A
-
V
D
W
A
----
N
F
Y
----
Q
-
A
D
----
V
R
E
T
N
N
--
L
T
---
A
A
I
T
L
L
Q
K
K
Q
V
E
A
V
M
F
D
R
P
A
----
L
I
Y
Y
-
T
R
Q
-----
N
P
N
--
L
N
L
---
E
V
T
E
----
I
------
R
V
S
L
E
P
Y
----
G
----
F
V
L
K
E
N
-
S
P
L
Q
K
T
I
N
V
E
M
L
N
L
L
Y
S
R
V
I
A
E
F
T
E
R
W
L
G
--------------------