@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1723: (2015-12-10 )
MKKILVLHTGGTISMNANEKGQVMSSADNPMKYVDLSLDDLDLTVVDFLNLPSPQITPHHMLDIYHYLKQHASNFDGVVITHGTDTLEETAYFLDTMILPKIPIIITGAMRSTNELGSDGVYNYLSALRVANSTKAADKGVLVVMNDEIHAAKYVTKTHTTNVSTFQTPTHGPLGIIMKQDLLFFKATEERVRFDLDKITGTVPIVKAYAGMGDSGIISFLNSQNISGLVIEALGAGNMPPKAAQEIEELIEQGVPVVLVSRCFNGIAEPVYGYEGGGARLQESGVMFVKELNAPKARLKLLIALNAGLTGQNLKDYIEG
Atome Classification :
(21 SA)
.........10........----20....------..------..30....-....40......-----------..50........60.......-.70-.--.------.-......80........90........-100.......110.......120.......130.......140.....-------.-------.150.......160.......170.......-180...-----....----190--.----.----.----..----....200-.----..---.....210.-...--...220.......230.......240.......250..-......260....-------...-270........280.......290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
L
V
L
HTG
G
T
I
S
MNANE----KG
Q
V
MS------SA------DN
P
M
K
Y
V
D
-LSLDDL
D
L
T
V
V
D
-----------
F
LNLPSPQIT
P
H
H
M
L
D
I
Y
H
Y
L
-
K
Q
--H--A------S-NFD
G
V
V
I
THGTD
T
L
E
E
T
A
Y
F
L
D
T
M
IL-PKI
P
I
I
I
T
GAMRSTNELGS
D
G
V
Y
N
Y
L
S
A
L
R
VANSTKAADK
G
V
L
V
V
MND-------E-------I
H
A
A
K
Y
V
T
K
THTTNVSTFQTPTHG
P
L
G
I
I
M
K-Q
D
L
L
F
F
-----KAT
E
----
E
----
R
----
V
----
R
----
F
D
----
L
D
K
ITG--T----
V
P
---
I
V
K
A
YAGMG-
D
S
G
--
I
I
S
F
L
NSQNI
S
G
L
V
I
E
ALGAGNMP
P
K
A
A
Q
E
I
E
E
L
I
-EQ-GVP
V
V
L
V
S
R
C
F
N
G
-------IAE-P-VYGYEGGGARLQES
G
V
M
F
V
KELNA
P
K
A
R
L
K
L
L
I
A
LNAGLTG
Q
N
L
K
D
Y
IEG-
52
Fugue
93.25
30%
-106
- C5 -
3ECA
2
ASPG2_ECOLI
A:
[1-326]
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
----
A
T
K
S
-
N
Y
T
V
GKV
G
V
------
E
N
L
V
N
A
V
P
-
Q
L
K
D
I
A
N
V
K
G
E
Q
-----------
V
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
K-
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
RKHT
S
----
D
----
T
----
P
----
F
D
----
V
S
K
L
N
----EL
P
K
V
G
---
I
V
Y
N
Y
A
N
A
--
S
D
L
--
P
A
K
A
L
V
D
A
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
-
T
G
T
A
V
V
R
S
S
R
V
P
T
--------------
G
A
T
T
Q
D
A
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
Y
31
HHSearch
93.17
30%
-107
- C5 -
1NNS
1
ASPG2_ECOLI
A:
[1-325]
L
P
N
I
T
I
L
A
T
G
G
T
I
A
G
G
G
D
S
ATK-
S
N
Y
T
V
G
KV----
G
V
------
E
N
L
V
N
A
V
P
Q
L
K
D
I
-
A
N
V
K
G
E
Q
-----------
V
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
-
K
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
----
R
----
K
----
H
----
T
SDTP
F
D
VS--
K
L
N
E
L
P
--
K
----
V
G
---
I
V
Y
N
Y
A
N
A
S
-
D
L
P
--
A
K
A
L
V
D
A
G
-
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
T
-
G
T
A
V
V
R
S
S
R
V
P
T
G
-------
A
T
T
-
Q
-
D
A
-----
E
V
D
D
A
K
Y
G
F
V
A
S
G
T
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
-
15
PsiBlast_PDB
92.93
31%
-105
- C5 -
3NXK
5
?
A:
[10-330]
--
R
I
A
I
L
G
T
G
G
T
I
A
G
F
I
D
S
----
T
I
A
T
T
G
------
Y
A
AGAID
I
D
V
L
I
K
A
V
P
-
Q
I
R
D
L
A
D
I
S
W
E
Q
-----------
I
A
N
I
D
S
S
N
M
C
D
E
I
W
L
R
L
A
K
K
I
A
K
L
--
F
--
A
------
E
-
G
I
D
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
N
L
T
I
K
-
S
D
K
P
V
V
L
V
G
A
M
R
P
S
T
A
I
S
A
D
G
P
K
N
L
Y
N
A
V
A
L
V
V
N
K
E
A
K
N
K
G
V
M
V
A
I
N
D
-------
K
-------
I
L
S
A
R
G
V
V
K
T
H
S
L
N
V
D
A
F
S
S
P
D
F
G
D
L
G
Y
I
V
D
-
G
K
V
F
F
Y
NNVI-
K
A
H
T
----
K
----
N
----
A
----
P
----
F
D
----
V
S
K
L
T
S
LP
K
----
V
D
---
I
L
Y
S
Y
S
N
D
G
-
S
G
V
--
A
A
K
A
L
F
E
H
G
T
K
G
I
V
V
A
G
S
G
A
G
S
I
H
K
N
Q
K
D
V
L
K
E
L
L
-
K
K
-
G
L
K
V
V
V
S
S
R
V
V
A
G
-------
C
V
A
-
V
-
S
D
S
D
E
-------
K
L
G
F
I
S
A
E
D
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
D
P
K
K
I
Q
E
Y
F
L
K
-
36
HHSearch
91.98
31%
-110
- C5 -
2WLT
1
ASPG_HELPJ
A:
[5-331]
L
P
T
I
A
L
L
A
T
G
G
T
I
A
G
S
G
--ASL-
G
S
Y
K
S
G
EL----
G
V
------
K
E
L
L
K
A
I
P
S
L
N
K
I
-
A
R
I
Q
G
E
Q
-----------
V
S
N
I
G
S
Q
D
M
N
E
E
I
W
F
K
L
A
Q
R
A
-
Q
E
--
L
L
D
D
------
S
-
R
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
-
S
T
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
-------
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
L
N
S
G
A
I
G
S
V
Y
Y
-
G
K
T
R
Y
Y
-----
M
Q
P
L
----
R
----
K
----
H
----
T
TESE
F
S
LSQ-
L
K
T
P
L
P
--
K
----
V
D
---
I
I
Y
T
H
A
G
M
T
-
P
D
L
--
F
Q
A
S
L
N
S
H
-
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
G
F
L
K
A
M
Q
E
A
S
-
Q
M
-
G
V
V
I
V
R
S
S
R
V
G
S
G
-------
G
V
T
-
S
G
E
I
-------
D
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
D
K
A
K
I
Q
E
M
F
E
E
-
33
HHSearch
91.64
29%
-106
- C5 -
1AGX
-
ASPQ_ACIGL
A:
[1-330]
K
N
N
V
V
I
V
A
T
G
G
T
I
A
G
A
G
A
S
STNS
A
T
Y
S
A
A
KV----
P
V
------
D
A
L
I
K
A
V
P
Q
V
N
D
L
-
A
N
I
T
G
I
Q
-----------
A
L
Q
V
A
S
E
S
I
T
D
K
E
L
L
S
L
A
R
Q
V
-
N
D
--
L
V
K
K
------
P
-
S
V
N
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
V
V
H
-
T
D
K
P
I
V
L
V
G
S
M
R
P
S
T
A
L
S
A
D
G
P
L
N
L
Y
S
A
V
A
L
A
S
S
N
E
A
K
N
K
G
V
M
V
L
M
N
D
-------
S
-------
I
F
A
A
R
D
V
T
K
G
I
N
I
H
T
H
A
F
V
S
Q
-
W
G
A
L
G
T
L
V
E
-
G
K
P
Y
W
F
-----
R
S
S
V
----
K
----
K
----
H
TNNS
E
----
F
N
IEKI
Q
G
D
A
L
P
--
G
----
V
Q
---
I
V
Y
G
S
D
N
M
M
-
P
D
A
--
Y
Q
A
F
A
K
A
G
-
V
K
A
I
I
H
A
G
T
G
N
G
S
M
A
N
Y
L
V
P
E
V
R
K
L
H
D
E
Q
-
G
L
Q
I
V
R
S
S
R
V
A
Q
G
-------
F
V
L
-
R
-
N
A
E
-----
Q
P
D
D
K
Y
G
W
I
A
A
H
D
L
N
P
Q
K
A
R
L
L
M
A
L
A
L
T
K
T
N
D
A
K
E
I
Q
N
M
F
W
N
-
37
HHSearch
91.27
31%
-109
- C5 -
3NXK
5
?
A:
[8-333]
K
S
R
I
A
I
L
G
T
G
G
T
I
A
G
F
I
D
S
TIAT
T
G
Y
A
A
G
AI----
D
I
------
D
V
L
I
K
A
V
P
Q
I
R
D
L
-
A
D
I
S
W
E
Q
-----------
I
A
N
I
D
S
S
N
M
C
D
E
I
W
L
R
L
A
K
K
I
-
A
K
--
L
F
-
A
------
E
-
G
I
D
G
V
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
N
L
T
I
K
-
S
D
K
P
V
V
L
V
G
A
M
R
P
S
T
A
I
S
A
D
G
P
K
N
L
Y
N
A
V
A
L
V
V
N
K
E
A
K
N
K
G
V
M
V
A
I
N
D
-------
K
-------
I
L
S
A
R
G
V
V
K
T
H
S
L
N
V
D
A
F
S
S
P
D
F
G
D
L
G
Y
I
V
D
-
G
K
V
F
F
Y
-----
N
N
V
I
----
K
----
A
----
H
TKNA
P
----
F
D
VS--
K
L
T
S
L
P
--
K
----
V
D
---
I
L
Y
S
Y
S
N
D
G
S
G
V
A
--
A
K
A
L
F
E
H
G
-
T
K
G
I
V
V
A
G
S
G
A
G
S
I
H
K
N
Q
K
D
V
L
K
E
L
L
-
K
K
-
G
L
K
V
V
V
S
S
R
V
V
A
G
-------
C
V
A
-
V
-
S
D
-------
S
D
E
K
L
G
F
I
S
A
E
D
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
D
P
K
K
I
Q
E
Y
F
L
K
-
35
HHSearch
89.59
27%
-114
* C5 *
1WSA
-
ASPG_WOLSU
A:
[3-329]
K
P
Q
V
T
I
L
A
T
G
G
T
I
A
G
----------
Y
S
A
G
A
V
----
T
V
------
D
K
L
L
A
A
V
P
A
I
N
D
L
-
A
T
I
K
G
E
Q
-----------
I
S
S
I
G
S
Q
E
M
T
G
K
V
W
L
K
L
A
K
R
V
-
N
E
--
L
L
A
Q
------
K
-
E
T
E
A
V
I
I
T
H
G
T
D
T
M
E
E
T
A
F
F
L
N
L
T
V
K
-
S
Q
K
P
V
V
L
V
G
A
M
R
P
G
S
S
M
S
A
D
G
P
M
N
L
Y
N
A
V
N
V
A
I
N
K
A
S
T
N
K
G
V
V
I
V
M
N
D
-------
E
-------
I
H
A
A
R
E
A
T
K
L
N
T
T
A
V
N
A
F
A
S
P
N
T
G
K
I
G
T
V
Y
Y
-
G
K
V
E
Y
F
-----
T
Q
S
V
----
R
----
P
----
H
----
T
LASE
F
D
IS--
K
I
E
E
L
P
--
R
----
V
D
---
I
L
Y
A
H
P
D
D
T
-
D
V
L
--
V
N
A
A
L
Q
A
G
-
A
K
G
I
I
H
A
G
M
G
N
G
N
P
F
P
L
T
Q
N
A
L
E
K
A
A
-
K
S
-
G
V
V
V
A
R
S
S
R
V
G
S
G
-------
S
T
T
----
Q
E
---
A
E
V
D
D
K
K
L
G
F
V
A
T
E
S
L
N
P
Q
K
A
R
V
L
L
M
L
A
L
T
K
T
S
D
R
E
A
I
Q
K
I
F
S
T
-
32
HHSearch
89.52
28%
-113
- C5 -
1ZQ1
2
GATD_PYRAB
A:
[91-421]
L
P
E
V
T
I
I
G
T
G
G
T
I
A
S
R
I
D
Y
E---
T
G
A
V
Y
P
A
F----
T
A
------
E
E
L
A
K
A
L
P
E
I
F
E
V
-
A
N
V
K
P
K
L
-----------
L
F
N
I
F
S
E
D
M
K
P
K
H
W
V
K
I
A
H
E
V
-
A
K
--
A
L
-
N
------
S
-
G
D
Y
G
V
V
V
A
H
G
T
D
T
M
G
Y
T
A
A
A
L
S
F
M
L
R
N
L
G
K
P
V
V
L
V
G
A
Q
R
S
S
D
R
P
S
S
D
A
A
M
N
L
I
C
S
V
R
M
A
T
S
E
---
V
A
E
V
M
V
V
M
H
G
-------
E
TGD
T
Y
C
L
A
H
R
G
T
K
V
R
K
M
H
T
S
R
R
D
A
F
R
S
I
N
D
V
P
I
A
K
I
W
P
N
G
E
I
E
F
L
-----
R
K
D
Y
----
R
----
K
----
R
----
S
D
E
E
-
V
E
V
---
D
D
K
I
E
E
--
K
----
V
A
---
L
V
K
V
Y
P
G
I
S
-
S
E
I
--
I
D
F
L
V
D
K
G
-
Y
K
G
I
V
I
E
G
T
G
L
G
H
T
P
N
D
I
I
P
S
I
E
R
A
V
-
E
E
-
G
V
A
V
C
M
T
S
Q
C
I
Y
G
-------
R
V
N
L
N
-
V
Y
S
---
T
G
R
K
L
L
K
A
G
V
I
P
C
E
D
M
L
P
E
T
A
Y
V
K
L
M
W
V
L
G
H
T
Q
N
L
E
E
V
R
K
M
M
L
T
-
7
PsiBlast_PDB
88.02
29%
-118
- C5 -
1HFW
2
ASPG_DICCH
A:
[4-311]
L
P
N
I
V
I
L
A
T
G
G
T
I
A
----------------------------------------
V
D
T
L
I
N
A
V
P
E
V
K
K
L
AN
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
-
N
E
L
L
A
--
R
------
D
-
D
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
-
N
R
I
Y
Y
Q
-----
N
R
I
D
----
K
LHTT
R
----
S
----
V
----
F
D
----
V
R
G
L
T
---
S
----
L
P
---
K
V
D
I
L
Y
G
Y
Q
-
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
-
E
K
-
G
V
V
V
M
R
S
T
R
T
G
N
G
-------
I
V
P
-
P
-
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
H
T
-
30
HHSearch
86.58
26%
-104
- C5 -
2D6F
-
GATD_METTH
A:
[90-418]
L
P
D
V
S
I
I
S
T
G
G
T
V
A
S
I
I
D
Y
R---
T
G
A
V
H
P
A
F
----
T
A
------
D
D
L
L
R
A
N
P
E
L
L
D
I
-
A
N
I
R
G
R
A
-----------
V
F
N
I
L
S
E
N
M
K
P
E
Y
W
V
E
T
A
R
A
V
-
Y
G
--
E
I
-
K
------
D
-
G
A
D
G
V
V
V
A
H
G
T
D
T
M
H
Y
T
S
A
A
L
S
F
M
L
R
-
T
P
V
P
V
V
F
T
G
A
Q
R
S
S
D
R
P
S
S
D
A
S
L
N
I
Q
C
S
V
R
A
A
T
S
E
---
I
A
E
V
T
V
C
M
H
A
TMDDLSC
H
-------
L
H
R
G
V
K
V
R
K
M
H
T
S
R
R
D
T
F
R
S
M
N
A
L
P
L
A
E
V
T
P
-
D
G
I
K
I
L
-----
E
E
N
Y
----
R
----
K
----
R
----
G
SDE-
L
E
L---
S
D
R
V
E
E
--
R
----
V
A
---
F
I
K
S
Y
P
G
I
S
-
P
D
I
--
I
K
W
H
L
D
E
G
-
Y
R
G
I
V
I
E
G
T
G
L
G
H
C
P
D
T
L
I
P
V
I
G
E
A
H
-
D
M
-
G
V
P
V
A
M
T
S
Q
C
L
N
G
-------
R
V
N
M
N
-
V
Y
S
---
T
G
R
R
L
L
Q
A
G
V
I
P
C
D
D
M
L
P
E
V
A
Y
V
K
M
C
W
V
L
G
Q
T
D
D
P
E
M
A
R
E
M
M
R
E
-
26
PsiBlast_CBE
86.27
31%
-111
- C5 -
1JAZ
2
ASPG2_ECOLI
B:
[54-310]
----------------------------------------------------------------------------
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
-
K
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
----
R
----
K
HTSD
T
----
P
----
F
D
----
V
S
K
L
N
E
LP
K
----
V
G
---
I
V
Y
N
Y
A
N
A
S
-
D
L
P
--
A
K
A
L
V
D
A
-
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
T
-
G
T
A
V
V
R
S
S
R
V
P
T
G
ATTQDAE
V
D
D
-
A
-
K
Y
G
F
V
A
S
G
T
------------
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
-
5
PsiBlast_PDB
85.80
29%
-106
- C5 -
1JSL
2
ASPG_DICCH
A:
[4-311]
L
P
N
I
V
I
L
A
T
G
G
T
I
A
G
S
A
A
T
----
G
T
Q
T
T
G
-----------------
Y
K
A
G
A
-
L
G
V
D
T
L
I
N
A
V
P
E
V
K
K
L
AN
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
-
N
E
L
L
A
--
R
------
D
-
D
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
-
N
R
I
Y
Y
Q
-----
N
R
I
D
----
K
LHTT
R
----
S
----
V
----
F
D
----
V
R
G
L
T
---
S
----
L
P
---
K
V
D
I
L
Y
G
Y
Q
-
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
-
E
K
-
G
V
V
V
M
R
S
T
R
T
G
N
G
-------
I
V
P
-
P
-
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
H
T
-
20
PsiBlast_PDB
85.73
31%
-114
- C5 -
1JJA
-
ASPG2_ECOLI
A:
[54-310]
----------------------------------------------------------------------------
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
-
K
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
----
R
----
K
HTSD
T
----
P
----
F
D
----
V
S
K
L
N
E
LP
K
----
V
G
---
I
V
Y
N
Y
A
N
A
S
-
D
L
P
--
A
K
A
L
V
D
A
-
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
T
-
G
T
A
V
V
R
S
S
R
V
P
T
G
ATTQDAE
V
D
D
-
A
-
K
Y
G
F
V
A
S
G
T
------------
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
-
4
PsiBlast_PDB
85.32
29%
-106
- C5 -
1HG0
1
ASPG_DICCH
A:
[4-311]
L
P
N
I
V
I
L
A
T
G
G
T
I
A
G
S
A
A
T
----
G
T
Q
T
T
G
-----------------
Y
K
A
G
A
-
L
G
V
D
T
L
I
N
A
V
P
E
V
K
K
L
AN
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
-
N
E
L
L
A
--
R
------
D
-
D
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
-
N
R
I
Y
Y
Q
-----
N
R
I
D
----
K
LHTT
R
----
S
----
V
----
F
D
----
V
R
G
L
T
---
S
----
L
P
---
K
V
D
I
L
Y
G
Y
Q
-
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
-
E
K
-
G
V
V
V
M
R
S
T
R
T
G
N
G
-------
I
V
P
-
P
-
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
H
T
-
18
PsiBlast_PDB
85.28
31%
-113
- C5 -
1IHD
-
ASPG2_ECOLI
A:
[54-310]
----------------------------------------------------------------------------
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
-
K
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
----
R
----
K
HTSD
T
----
P
----
F
D
----
V
S
K
L
N
E
L
P
K
----
V
G
---
I
V
Y
N
Y
A
N
A
S
-
D
L
P
--
A
K
A
L
V
D
A
-
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
T
-
G
T
A
V
V
R
S
S
R
V
P
T
G
ATTQDAE
V
D
D
-
A
-
K
Y
G
F
V
A
S
G
T
------------
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
-
19
PsiBlast_PDB
85.12
31%
-109
- C5 -
1JAZ
1
ASPG2_ECOLI
A:
[54-310]
----------------------------------------------------------------------------
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
-
K
T
D
G
F
V
I
T
H
G
T
E
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
----
R
----
K
HTSD
T
----
P
----
F
D
----
V
S
K
L
N
E
LP
K
----
V
G
---
I
V
Y
N
Y
A
N
A
S
-
D
L
P
--
A
K
A
L
V
D
A
-
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
T
-
G
T
A
V
V
R
S
S
R
V
P
T
G
ATTQDAE
V
D
D
-
A
-
K
Y
G
F
V
A
S
G
T
------------
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
-
6
PsiBlast_PDB
85.11
29%
-107
- C5 -
1JSR
2
ASPG_DICCH
A:
[4-311]
L
P
N
I
V
I
L
A
T
G
G
T
I
A
G
S
A
A
T
----
G
T
Q
T
T
G
-----------------
Y
K
A
G
A
-
L
G
V
D
T
L
I
N
A
V
P
E
VKKLAN
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
-
N
E
L
L
A
--
R
------
D
-
D
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
-
N
R
I
Y
Y
Q
-----
N
R
I
D
----
K
LHTT
R
----
S
----
V
----
F
D
----
V
R
G
L
T
---
S
----
L
P
---
K
V
D
I
L
Y
G
Y
Q
-
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
-
E
K
-
G
V
V
V
M
R
S
T
R
T
G
N
G
-------
I
V
P
-
P
-
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
H
T
-
3
PsiBlast_PDB
84.82
29%
-107
- C5 -
1HFJ
1
ASPG_DICCH
A:
[4-311]
L
P
N
I
V
I
L
A
T
G
G
T
I
A
G
S
A
A
T
----
G
T
Q
T
T
G
-----------------
Y
K
A
G
A
-
L
G
V
D
T
L
I
N
A
V
P
E
VKKLAN
V
K
G
E
Q
F
S
N
M
A
S
E
N
M
T
G
D
V
V
L
K
L
S
Q
R
V
-
N
E
L
L
A
--
R
------
D
-
D
V
D
G
V
V
I
T
H
G
T
D
T
V
E
E
S
A
Y
F
L
H
L
T
V
K
-
S
D
K
P
V
V
F
V
A
A
M
R
P
A
T
A
I
S
A
D
G
P
M
N
L
L
E
A
V
R
V
A
G
D
K
Q
S
R
G
R
G
V
M
V
V
I
N
D
-------
R
-------
I
G
S
A
R
Y
I
T
K
T
N
A
S
T
L
D
T
F
R
A
N
E
E
G
Y
L
G
V
I
I
G
-
N
R
I
Y
Y
Q
-----
N
R
I
D
----
K
LHTT
R
----
S
----
V
----
F
D
----
V
R
G
L
T
---
S
----
L
P
---
K
V
D
I
L
Y
G
Y
Q
-
D
D
P
E
Y
L
Y
D
A
A
I
Q
H
G
V
K
G
I
V
Y
A
G
M
G
A
G
S
V
S
V
R
G
I
A
G
M
R
K
A
L
-
E
K
-
G
V
V
V
M
R
S
T
R
T
G
N
G
-------
I
V
P
-
P
-
D
E
E
L
P
G
----------
L
V
S
D
S
L
N
P
A
H
A
R
I
L
L
M
L
A
L
T
R
T
S
D
P
K
V
I
Q
E
Y
F
H
T
-
2
PsiBlast_PDB
84.09
36%
-119
- C5 -
2WT4
1
ASPG_HELPJ
A:
[68-316]
------------------------------------------------------------------------------------------
E
I
W
F
K
L
-
A
Q
--
R
--
A
Q
E
L
L
D
D
S
-
R
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
-
S
T
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
-------
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
L
N
S
G
A
I
G
S
V
Y
Y
-
G
K
T
R
Y
Y
MQPLR
K
H
T
T
----
E
----
S
---------
E
----
F
S
----
L
S
Q
L
K
T
--
P
----
L
P
K
V
D
I
I
Y
T
H
A
G
M
T
-
P
D
L
--
F
Q
A
S
L
N
S
-
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
G
F
L
K
A
M
Q
E
A
S
-
Q
M
-
G
V
V
I
V
R
S
S
R
V
G
S
G
---------------
G
V
T
S
G
E
I
D
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
D
K
A
K
I
Q
E
M
F
E
E
-
21
PsiBlast_CBE
83.70
31%
-115
- C5 -
3ECA
2
ASPG2_ECOLI
D:
[54-310]
----------------------------------------------------------------------------
V
N
I
G
S
Q
D
M
N
D
N
V
W
L
T
L
A
K
K
I
-
N
T
--
D
--
C
------
D
-
K
T
D
G
F
V
I
T
H
G
T
D
T
M
E
E
T
A
Y
F
L
D
L
T
V
K
-
C
D
K
P
V
V
M
V
G
A
M
R
P
S
T
S
M
S
A
D
G
P
F
N
L
Y
N
A
V
V
T
A
A
D
K
A
S
A
N
R
G
V
L
V
V
M
N
D
-------
T
-------
V
L
D
G
R
D
V
T
K
T
N
T
T
D
V
A
T
F
K
S
V
N
Y
G
P
L
G
Y
I
H
N
-
G
K
I
D
Y
Q
-----
R
T
P
A
----
R
----
K
HTSD
T
----
P
----
F
D
----
V
S
K
L
N
E
LP
K
----
V
G
---
I
V
Y
N
Y
A
N
A
S
-
D
L
P
--
A
K
A
L
V
D
A
-
G
Y
D
G
I
V
S
A
G
V
G
N
G
N
L
Y
K
S
V
F
D
T
L
A
T
A
A
-
K
T
-
G
T
A
V
V
R
S
S
R
V
P
T
G
ATTQDAE
V
D
D
-
A
-
K
Y
G
F
V
A
S
G
T
------------
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
Q
T
K
D
P
Q
Q
I
Q
Q
I
F
N
Q
-
1
PsiBlast_PDB
83.09
36%
-116
- C5 -
2WLT
1
ASPG_HELPJ
A:
[68-316]
------------------------------------------------------------------------------------------
E
I
W
F
K
L
-
A
Q
--
R
--
A
Q
E
L
L
D
D
S
-
R
I
Q
G
V
V
I
T
H
G
T
D
T
L
E
E
S
A
Y
F
L
N
L
V
L
H
-
S
T
K
P
V
V
L
V
G
A
M
R
N
A
S
S
L
S
A
D
G
A
L
N
L
Y
E
A
V
S
V
A
V
N
E
K
S
A
N
K
G
V
L
V
V
M
D
D
-------
T
-------
I
F
S
V
R
E
V
V
K
T
H
T
T
H
V
S
T
F
K
A
L
N
S
G
A
I
G
S
V
Y
Y
-
G
K
T
R
Y
Y
MQPLR
K
H
T
T
----
E
----
S
---------
E
----
F
S
----
L
S
Q
L
K
T
--
P
----
L
P
K
V
D
I
I
Y
T
H
A
G
M
T
-
P
D
L
--
F
Q
A
S
L
N
S
-
H
A
K
G
V
V
I
A
G
V
G
N
G
N
V
S
A
G
F
L
K
A
M
Q
E
A
S
-
Q
M
-
G
V
V
I
V
R
S
S
R
V
G
S
G
---------------
G
V
T
S
G
E
I
D
D
K
A
Y
G
F
I
T
S
D
N
L
N
P
Q
K
A
R
V
L
L
Q
L
A
L
T
K
T
N
D
K
A
K
I
Q
E
M
F
E
E
-