@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1725: (2015-12-10 )
MLQNIGQTGIQATRIALGCMRMSDLEGKQAEEVVGTALDLGINFFDHADIYGGGLSELRFRDAIKHLNVNRDKMIIQSKCGIREGYFDFSKEYILSSVDGILERLGTEYLDFLILHRPDVLVEPEEVAEAFTKLRAEGKVKHFGVSNQNRFQMELLQSYLDEPLAVNQLQLSPAHTPMFDAGLNVNMLNKASIEHDDGIVDYCRLKRVTIQAWSPFQIDLSRGLFVNHPDYKELNETIAKLAKNYNVSSEAIVIAWILRHPAQIQAIVGSMNPSRLKAIDKANDIALTREEWYDIYRSAGNILP
Atome Classification :
(20 SA)
--...---......10........20.--.------.------.-----....30........40........50.-.-------......60......-..70........80--..--------..----.--------....90-----........100.......110.......120-----------------.......130.......140.......150.......160--.----........170....--...180.......190.......200.......210.......220...------------------------.---------------..------.230--------------------------.----------------------------..---...-----------------..---------.240-----..----......-250.......260.......270.......280..-.--.--...290.......300..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MLQ---
N
I
G
QTG
I
Q
A
T
R
I
A
L
G
C
M
R
M
--S------D------L-----EG
K
Q
A
E
E
V
V
G
T
A
L
D
L
G
I
N
FFDHADIYG-G-------
G
L
S
E
L
R
F
R
D
A
I
K
HL-NVNR
D
K
M
I
I
QSKC---GI--------RE----
G
--------
Y
F
D
F
S
K
-----
E
Y
I
L
S
S
V
D
G
I
L
E
R
L
G
T
E
Y
L
D
F
L
I
LHRPDVLV-----------------
E
P
E
E
V
A
E
A
F
T
K
L
RAEGK
V
K
H
FGVSNQ
N
R
F
Q
M
E
L
L
Q
S
YL----D----EPLAV
N
Q
L
QLSPAHT--PMFDAGL
N
V
N
M
LNKASIEHDDG
I
V
D
Y
C
R
L
K
R
V
T
I
Q
AWS
P
F
Q
I
DLSR
G
L
F------------------------V---------------NH------P
D
----------------------------
Y
----------------------------
K
E
---
L
N
E
-----------------
T
I
---------
A
K
L
------
A
K
----NYNVSS-
E
A
I
V
I
A
W
I
LRH
P
A
Q
I
Q
A
I
VGSM
N
P
S
R
L
K
A
IDKAND-
I
--
A
--
L
T
R
E
E
W
Y
D
I
Y
R
SAGNILP
2
PsiBlast_PDB
91.52
36%
-104
- C3 -
1OG6
1
YDHF_ECOLI
A:
[6-292]
--------
T
I
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
--
M
------
D
WN----
M
-----
S
A
R
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
-
P
H
L
R
E
R
M
E
I
V
S
K
C
---
G
I
ATTA----
R
E
ENV
I
G
--------
H
Y
I
T
D
R
-----
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
R
P
D
P
L
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
Q
S
R
L
----
P
----
F
T
L
A
T
N
Q
V
E
I
S
P
V
H
Q
--
P
L
L
----------------
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
----
L
G
G
G
R
L
------------------------
F
---------------
N
D
------
D
Y
----------------------------
F
----------------------------
Q
P
---
L
R
D
-----------------
E
L
---------
A
V
V
------
A
E
----
E
L
N
A
G
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
--
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
1
PsiBlast_PDB
90.53
35%
-104
- C3 -
4R9O
-
?
A:
[9-295]
--------
T
I
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
--
M
------
D
WN----
M
-----
S
A
R
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
T
L
A
-
P
H
L
R
E
K
L
Q
I
V
T
K
C
---
G
I
ATTARAEN
K
L
----
G
--------
H
Y
I
T
D
R
-----
R
H
I
I
L
S
A
E
Q
S
L
K
N
L
A
T
D
Y
L
D
M
L
L
I
H
R
P
D
P
L
M
-----------------
D
A
D
D
V
A
E
A
F
Q
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
T
L
L
Q
S
R
L
----
P
----
F
T
L
A
T
N
Q
V
E
I
S
P
V
H
Q
--
P
L
L
----------------
L
D
G
T
L
D
Q
L
Q
Q
L
R
I
R
P
M
A
W
S
----
C
L
G
G
G
R
L
------------------------
F
---------------
N
D
------
E
A
----------------------------
Y
----------------------------
Q
P
---
L
R
Q
-----------------
E
L
---------
S
V
I
------
A
Q
----
E
L
N
A
S
S
I
E
Q
V
V
Y
A
W
I
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
L
E
A
E
T
-
L
--
S
--
L
T
R
Q
Q
W
F
R
I
R
K
A
A
L
----
22
PsiBlast_CBE
90.13
36%
-102
- C3 -
1OG6
1
YDHF_ECOLI
B:
[6-292]
--------
T
I
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
--
M
------
D
WN----
M
-----
S
A
R
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
-
P
H
L
R
E
R
M
E
I
V
S
K
C
---
G
I
ATTA----
R
E
ENV
I
G
--------
H
Y
I
T
D
R
-----
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
R
P
D
P
L
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
Q
S
R
L
----
P
----
F
T
L
A
T
N
Q
V
E
I
S
P
V
H
Q
--
P
L
L
----------------
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
--------
R
L
------------------------
F
---------------
N
D
------
D
Y
----------------------------
F
----------------------------
Q
P
---
L
R
D
-----------------
E
L
---------
A
V
V
------
A
E
----
E
L
N
A
G
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
--
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
21
PsiBlast_CBE
90.12
36%
-104
- C3 -
1OG6
1
YDHF_ECOLI
C:
[6-292]
--------
T
I
A
P
Q
G
P
E
F
S
R
F
V
M
G
Y
W
R
L
--
M
------
D
WN----
M
-----
S
A
R
Q
L
V
S
F
I
E
E
H
L
D
L
G
V
T
T
V
D
H
A
D
I
Y
G
-
G
-------
Y
Q
C
E
A
A
F
G
E
A
L
K
L
A
-
P
H
L
R
E
R
M
E
I
V
S
K
C
---
G
I
ATTA----
R
E
ENVI
G
--------
H
Y
I
T
D
R
-----
D
H
I
I
K
S
A
E
Q
S
L
I
N
L
A
T
D
H
L
D
L
L
L
I
H
R
P
D
P
L
M
-----------------
D
A
D
E
V
A
D
A
F
K
H
L
H
Q
S
G
K
V
R
H
F
G
V
S
N
F
T
P
A
Q
F
A
L
L
Q
S
R
L
----
P
----
F
T
L
A
T
N
Q
V
E
I
S
P
V
H
Q
--
P
L
L
----------------
L
D
G
T
L
D
Q
L
Q
Q
L
R
V
R
P
M
A
W
S
C
----
L
G
G
G
R
L
------------------------
F
---------------
N
D
------
D
Y
----------------------------
F
----------------------------
Q
P
---
L
R
D
-----------------
E
L
---------
A
V
V
------
A
E
----
E
L
N
A
G
S
I
E
Q
V
V
N
A
W
V
L
R
L
P
S
Q
P
L
P
I
I
G
S
G
K
I
E
R
V
R
A
A
V
E
A
E
T
-
L
--
K
--
M
T
R
Q
Q
W
F
R
I
R
K
A
A
L
G
Y
D
V
32
HHSearch
85.84
31%
-95
- C3 -
1PZ1
1
GS69_BACSU
A:
[3-311]
---
Y
T
---
S
I
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
A
I
--
G
------
G
TMWGG-
T
-----
D
E
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
-
F
-------
G
Q
S
E
E
I
V
G
K
A
I
K
E
Y
--
M
K
R
D
Q
V
I
L
A
T
K
T
---
A
L
--------
D
W
----
K
NN
Q
L
----
F
R
H
A
N
R
-----
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
V
-----------------
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
I
E
Q
M
D
T
F
R
A
------
V
----
A
P
L
H
T
I
Q
P
P
Y
N
L
F
E
R
--
E
M
E
-----------------
E
S
V
L
P
Y
A
K
D
N
K
I
T
T
L
L
Y
G
S
----
L
C
R
G
L
L
------------------------
T
---------------
G
K
------
M
T
----------------------------
E
E
Y
T
F
E
G
DDLRNHDPKFQKPR
F
K
E
Y
----
L
S
---
A
V
N
-----------------
Q
L
---------
D
K
L
------
A
K
T
---
R
Y
G
K
S
V
-
I
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
--
L
N
S
E
D
Q
K
D
I
N
T
I
L
E
N
T
I
S
6
PsiBlast_PDB
85.79
26%
-95
- C3 -
3V0U
-
PERR_RAUSE
A:
[5-305]
--------
K
L
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
M
G
L
--
S
------
G
DYNDA-
L
-----
P
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
E
N
-------
G
S
N
E
E
L
L
G
K
A
L
K
Q
L
-
P
--
R
E
K
I
Q
V
G
T
K
F
---
G
I
--------
H
E
----
I
--------
G
F
S
G
V
K
A
K
G
T
P
D
Y
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
R
I
D
T
T
V
-----------------
P
I
E
I
T
M
G
E
L
K
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
P
D
T
I
R
--
R
A
H
A
----
V
----
H
P
V
T
A
L
Q
I
E
Y
S
-----------------
L
W
T
R
D
I
E
--
D
E
I
V
P
L
C
R
Q
L
G
I
G
I
V
P
Y
S
------------------------------------------------------------------------------------------N---------------------------
K
Q
---
I
Y
Y
-----------------
R
I
---------
E
A
L
------
S
Q
----
K
H
G
C
T
P
-
V
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
--
L
T
K
E
D
L
K
E
I
S
D
A
V
P
A
N
T
P
4
PsiBlast_PDB
83.54
27%
-105
- C3 -
1PZ1
1
GS69_BACSU
A:
[5-306]
--------
S
I
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
A
I
--
G
------
G
------
T
MWGGT
D
E
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
-
F
-------
G
Q
S
E
E
I
V
G
K
A
I
K
E
Y
--
M
K
R
D
Q
V
I
L
A
T
K
T
---
A
L
D
W
K
N----
N
Q
----
L
--------
F
R
H
A
N
R
-----
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
V
-----------------
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
---
F
S
I
E
Q
M
D
T
F
-----------------
R
A
V
A
P
L
H
T
I
Q
P
P
Y
------
N
L
F
E
R
---
E
M
E
E
S
V
L
P
Y
A
K
D
N
K
I
T
T
L
L
Y
G
----
S
L
C
R
G
L
L
------------------------
T
GKMTEE
Y
T
F
E
G
DDLR
N
H
DPKFQK
P
R
----------------------------
F
----------------------------
K
E
---
Y
L
S
-----------------
A
V
---------
N
Q
L
------
D
K
L
A
K
T
R
Y
G
K
S
V
-
I
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
--
L
N
S
E
D
Q
K
D
I
N
T
I
L
E
N
T
I
S
7
PsiBlast_PDB
81.84
26%
-90
- C3 -
3V0T
1
PERR_RAUSE
A:
[5-305]
--------
K
L
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
M
G
L
--
S
-------------------
P
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
E
N
-------
G
S
N
E
E
L
L
G
K
A
L
K
Q
L
-
P
--
R
E
K
I
Q
V
G
T
K
F
---
G
I
--------
H
E
----
I
--------
G
F
S
G
V
K
A
K
GT
P
D
Y
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
R
I
D
T
T
V
-----------------
P
I
E
I
T
M
G
E
L
K
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
P
D
T
I
R
--
R
A
H
A
----
V
----
H
P
V
T
A
L
Q
I
E
Y
S
-----------------
L
W
T
R
D
I
E
--
D
E
I
V
P
L
C
R
Q
L
G
I
G
I
V
P
Y
S
P
----
I
G
R
G
L
F
W
G
K
A
I
K
E----------------------------------------------------------------------------------------------------------
Y
Y
-----------------
R
I
---------
E
A
L
------
S
Q
----
K
H
G
C
T
P
-
V
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
--
L
T
K
E
D
L
K
E
I
S
D
A
V
P
W
K
F
A
5
PsiBlast_PDB
81.49
26%
-93
- C3 -
3UYI
-
PERR_RAUSE
A:
[5-305]
--------
K
L
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
M
G
L
--
S
------
G
------
L
-----
P
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
E
N
-------
G
S
N
E
E
L
L
G
K
A
L
K
Q
L
-
P
--
R
E
K
I
Q
V
G
T
K
F
---
G
I
--------
H
E
----
I
--------
G
F
S
G
V
K
A
K
G
T
P
D
Y
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
R
I
D
T
T
V
-----------------
P
I
E
I
T
M
G
E
L
-
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
P
D
T
I
R
--
R
A
H
A
----
V
----
H
P
V
T
A
L
Q
I
E
Y
S
-----------------
L
W
T
R
D
I
E
--
D
E
I
V
P
L
C
R
Q
L
G
I
G
I
V
P
Y
S
P
----
I
G
R
G
L
F
AG
K
A
I
K
E
S-----------------------------------------------------------------------KN--------------------------
K
Q
---
I
Y
Y
-----------------
R
I
---------
E
A
L
------
S
Q
----
K
H
G
C
T
P
-
V
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
--
L
T
K
E
D
L
K
E
I
S
D
A
V
P
L
D
E
V
30
HHSearch
77.71
25%
-87
- C3 -
3ERP
17
?
A:
[35-350]
--
E
Y
R
---
R
C
G
R
S
G
V
K
L
P
A
I
S
L
G
L
W
H
N
--
F
------
G
DT----
T
-----
R
V
E
N
S
R
A
L
L
Q
R
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
G
-
P
PP-----
G
S
A
E
C
N
F
G
R
I
L
Q
E
D
F
L
P
W
R
D
E
L
I
I
S
T
K
A
---
G
Y
--------
T
M
----
W
DGPY----
G
D
W
G
S
R
-----
K
Y
L
I
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
H
H
R
P
D
P
E
T
-----------------
P
L
K
E
T
M
K
A
L
D
H
L
V
R
H
G
K
A
L
Y
V
G
I
S
N
Y
P
A
D
L
A
R
Q
A
I
D
I
L
E
D
L
-
G
----
T
P
C
L
I
H
Q
P
K
Y
S
L
F
E
R
--
W
V
E
-----------------
D
G
L
L
A
L
L
Q
E
K
G
V
G
S
I
A
F
S
P
----
L
A
G
G
Q
L
------------------------
T
---------------
D
R
------
Y
L
NIT
A
D
-----------------------
K
----------------------------
L
E
---
K
V
R
-----------------
R
L
---------
N
E
L
------
A
A
----
R
R
G
Q
K
L
-
S
Q
M
A
L
A
W
V
L
R
N
D
N
V
T
S
V
L
I
G
A
S
K
P
S
Q
I
E
D
A
V
G
M
L
A
N
R
--
R
--
F
S
A
A
E
C
A
E
I
D
A
I
L
E
G
R
F
-
27
HHSearch
77.00
23%
-91
- C3 -
3LUT
1
KCAB2_RAT
A:
[39-356]
---
Y
R
---
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
--
F
G-----
G
Q-----
I
-----
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
-
G
W
R
R
S
S
L
V
I
T
T
K
I
---
F
W
--------
G
G
----
K
AET-----
E
R
G
L
S
R
-----
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
----
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
--
E
K
V
E
----------------
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
----
L
A
C
G
I
V
------------------------
S
---------------
G
K
------
Y
D
SGIPPYSRASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
----------------------------
Q
A
---
K
L
K
-----------------
E
L
---------
Q
A
I
------
A
E
----
R
L
G
C
T
L
-
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
--
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
25
HHSearch
76.65
23%
-90
* C3 *
3EAU
3
KCAB2_RAT
A:
[4-323]
--
F
Y
R
---
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
--
F
------
G
GQ----
I
-----
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
-
G
W
R
R
S
S
L
V
I
T
T
K
I
---
F
W
--------
G
G
----
K
AET-----
E
R
G
L
S
R
-----
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
R
Q
F
N
L
----
I
P
P
I
C
E
Q
A
E
Y
H
M
F
Q
R
--
E
K
V
E
----------------
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
----
L
A
C
G
I
V
------------------------
S
---------------
G
K
------
Y
D
----------------------------
S
GIPPYSRASLKGY
Q
W
L
K
D
K
I
L
S
E
E
G
R
R
Q
Q
A
---
K
L
K
-----------------
E
L
---------
Q
A
I
------
A
E
----
R
L
G
C
T
L
-
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
--
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
31
HHSearch
76.47
27%
-91
- C3 -
1PYF
3
IOLS_BACSU
A:
[3-309]
---
K
A
---
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
--
G
------
G
HNLYPN
L
-----
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
-
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
---
F
N
R
E
D
V
V
I
A
T
K
A
---
A
H
--------
R
K
----
Q
GN
D
F
----
V
F
D
N
S
P
-----
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
E
Q
L
K
E
A
N
K
------
D
----
G
L
V
D
V
L
Q
G
E
Y
N
L
L
N
R
--
E
A
E
-----------------
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
----
L
V
S
G
L
L
------------------------
A
---------------
G
K
------
Y
T
----------------------------
E
D
T
T
F
P
EGDLRNEQEHFKG
E
R
F
K
E
N
----
I
R
---
K
V
N
-----------------
K
L
---------
A
P
I
------
A
E
----
K
H
N
V
D
I
-
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
--
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
P
G
--
44
HHSearch
75.94
27%
-88
- C3 -
1VBJ
2
PGFS_TRYBB
A:
[11-266]
----
S
---
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
W
K
L
--
Q
------
D
-------------
G
N
E
A
E
T
A
T
M
W
A
I
K
S
G
Y
R
H
I
D
T
A
A
I
Y
K
-
N
----------
E
E
S
A
G
R
A
I
A
S
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
---
W
N
--------
S
----------------
D
Q
G
Y
-----
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
G
K
D
K
------------------
F
I
D
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
----
K
----
V
A
P
M
V
N
Q
I
E
L
H
P
L
L
N
--
Q
-------------------
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
G
Q
G
H
L
------------------------
V
---------------
E
D
------------------------------------------------------------------------
A
-----------------
R
L
---------
K
A
I
------
G
G
----
K
Y
G
K
T
A
-
A
Q
V
M
L
R
W
E
I
Q
A
G
V
--
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
-
F
--
E
--
L
T
A
E
D
I
Q
V
I
D
G
M
N
A
G
H
R
Y
48
Fugue
75.80
22%
-86
- C3 -
1QRQ
1
KCAB2_RAT
A:
[1-325]
LQ
F
Y
R
---
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
FG
G
------
Q
------
I
-----
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
-
G
W
R
R
S
S
L
V
I
T
T
K
I
F
WG
G
K
--------
A
E
----
T
--------
E
R
G
L
S
R
-----
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
A
----
R
----
Q
F
----
N
L
I
P
P
I
C
E
Q
--
A
E
Y
------
H
M
F
Q
R
E
K
V
E
V
Q
--
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
DSG
I
P
P
Y
S
RASLKGY
Q
W
L
K
D
K
I
L
S
E
---------------
E
G
------
R
R
----------------------------
Q
----------------------------
Q
A
---
K
L
K
-----------------
E
L
---------
Q
A
I
------
A
E
----
R
L
G
C
T
L
-
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
--
L
PK
L
S
S
S
I
V
H
E
I
D
S
I
L
G
N
K
P
Y
40
HHSearch
75.68
27%
-93
- C3 -
3O0K
4
?
A:
[28-282]
---
T
V
---
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
--
S
--------------------
N
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
-
N
----------
E
E
G
V
G
K
A
I
N
G
S
-
G
I
A
R
A
D
I
F
L
T
T
K
L
---
W
N
--------
S
----------------
D
Q
G
Y
-----
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
K
D
----------------
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
----
G
----
V
T
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
--
Q
-------------------
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
----
L
G
Q
G
-
L
------------------------
L
---------------
E
D
------------------------------------------------------------------------
P
-----------------
T
L
---------
K
S
I
------
A
E
----
K
H
A
K
S
V
-
A
Q
I
I
L
R
W
H
I
E
T
G
--
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
-
F
--
T
--
L
N
G
T
D
H
D
A
I
T
K
L
D
-----
8
PsiBlast_PDB
75.26
24%
-94
- C3 -
1ZSX
4
KCAB2_HUMAN
A:
[24-317]
----
Q
FYR
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
FG
G
------
Q
------
I
-----
T
D
E
M
A
E
Q
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
-
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
-
G
W
R
R
S
S
L
V
I
T
T
K
I
F
WG
G
K
--------
A
E
----
T
--------
E
R
G
L
S
R
-----
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
T
-----------------
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
--
S
M
E
I
M
E
A
Y
------------
S
V
A
R
Q
F
N
L
T
P
-----
P
I
C
E
Q
A
-
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
--
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
DSGIPPYSR---------------
A
---------------
S
L
------
K
G
----------------------------
Y
----------------------------
Q
W
---
L
K
D
-----------------
K
I
L
S
E
E
G
R
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
----
R
L
G
C
T
L
-
P
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
D
Q
L
M
E
N
I
G
A
I
Q
-
V
--
L
--
P
K
L
S
S
S
I
I
H
E
I
D
S
I
L
G
N
K
26
HHSearch
74.27
21%
-91
- C3 -
1LQA
1
TAS_ECOLI
A:
[3-338]
---
Y
H
---
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
M
T
F
--
G
------
E
Q-----
N
-----
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
-
V
PPRPETQ
G
L
T
E
T
Y
V
G
N
W
L
A
K
H
--
G
S
R
E
K
L
I
I
A
S
K
V
---
S
G
--------
P
S
----
R
NNDKGIRP
D
Q
A
L
D
R
-----
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
T
NCFGKL
G
Y
S
W
T
DSAPAV
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
F
G
V
M
R
Y
L
H
L
A
----
D
K
H
DL
P
R
I
V
T
I
Q
N
P
Y
S
L
L
N
R
--
S
F
E
-----------------
V
G
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
----
L
G
F
G
T
L
------------------------
T
---------------
G
K
------
Y
L
NGAKPAGA
R
N
T
L
F
SRFTRYSG
E
Q
-----
T
----------------------------
Q
K
---
A
V
A
-----------------
A
Y
---------
V
D
I
------
A
R
----
R
H
G
L
D
P
-
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
--
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
12
PsiBlast_PDB
74.15
25%
-96
- C3 -
1PZ0
2
IOLS_BACSU
A:
[6-301]
---------
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
--
G
GHNLYP
N
------
L
-----
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
-
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
F
-
N
--
R
E
D
V
V
I
A
T
K
A
---
A
H
--------
R
K
----
Q
GN
D
F
----
V
F
D
N
S
P
-----
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
---
F
S
L
E
Q
L
K
E
A
N
----
K
----
D
G
L
-
V
D
V
L
Q
G
E
--------------
Y
N
L
L
N
R
---
E
A
E
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
------------------------
T
---------------
E
D
------
T
T
----------------------------
F
----------------------------
P
E
GDL
R
N
E
QEHFKGE
R
F
K
E
N
I
R
K
V
N
K
L
---------
A
P
I
------
A
E
----
K
H
N
V
D
I
-
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
--
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
P
G
--
11
PsiBlast_PDB
74.06
25%
-98
- C3 -
1PYF
2
IOLS_BACSU
A:
[6-301]
---------
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
--
G
GHNLYP
N
------
L
-----
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
-
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
F
-
N
--
R
E
D
V
V
I
A
T
K
A
---
A
H
--------
R
K
----
Q
GN
D
F
----
V
F
D
N
S
P
-----
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
---
F
S
L
E
Q
L
K
E
A
N
----
K
----
D
G
L
-
V
D
V
L
Q
G
E
--------------
Y
N
L
L
N
R
---
E
A
E
K
T
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
------------------------
T
---------------
E
D
------
T
T
----------------------------
F
----------------------------
P
E
GDL
R
N
E
QEHFKG
E
R
F
K
E
N
I
R
K
V
N
K
L
---------
A
P
I
------
A
E
----
K
H
N
V
D
I
-
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
--
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
P
G
--