@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1764: (2015-12-10 )
MNNKILEQLEFNKVKELILPYLKTEQSQEELSELEPMTEAPKIEKSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLELSADLNIQELLVIKKVLQSSSDMIHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTNSERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADERHEESRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPEISNDSTLALINVRHPLLSNPVANDLHFDQDLTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEADHNSLVLFDELGAGTDPQEGASLAMAILEHLRLSNIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPGRSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEIEQENLKFNRAVKKLYNEFSHERDKELEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVTSYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFTLVRVQEEQKVKSKQINVVKKADSSGPRARLDLRGKRYEEAMQELDNFIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG
Atome Classification :
(20 SA)
.........10..------.---------.....20........30...--.....40........50......---..60.-.......70........80........90........100....-...110....-....----120.......130..-....--------.--------140-----...-..-....150.......160.......170.....----..180.......190.......200.......210.......220.......230.......240.......250.......260.......270..-----.....280.--......290-----...--.....300....----.---.-------.310---........-.-320..-.....330.......340.......350.......360.......370.......380.......390......-.400.......410.......420.......430-.-...--...440.......-450..-.....460.--.--.....470-.....----...480.......490.......500........510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
N
K
I
L
E
Q
L
E
F
N
K
------
V
---------
K
E
L
I
L
P
Y
LKT
E
Q
S
Q
E
E
L
S
EL--EPMTEAP
K
I
E
K
S
F
N
E
I
S
D
M
E
Q
I
F
---
V
E
HHS-F
G
I
V
S
L
S
S
I
S
E
S
L
K
R
L
ELSADL
N
I
Q
E
L
L
V
I
K
K
V
L
QSSS
D
M
I
H
F
Y-SDLDN-V
S
F
Q
-
S
L
D
R
----
L
F
E
N
L
E
Q
FPNLQG
S
F
-
Q
AIN--------D--------G-------G
F
L
-
E
H-FASP
E
L
E
R
I
R
R
Q
LT
N
S
E
R
R
V
R
Q
I
L
Q
D
M
L
K
E
K
A
----
E
L
L
S
E
N
L
IASRSG
R
S
VLP
V
K
N
T
Y
R
N
R
I
S
G
V
V
H
DISSSG
S
T
V
Y
IEP
R
A
V
V
T
L
N
E
E
I
T
Q
L
RAD
E
R
H
E
E
S
R
I
L
H
A
F
S
D
L
L
R
P
H
V
A
T
IRN
N
A
W
I
L
G
H
L
D
F
V
-----
R
A
K
Y
L
F
MSD--NKATIPEI------SND--
S
T
L
A
L
I
N
VRHPL----L---S-------NP-----VANDLHFD-Q-D
L
T
A
I
-
V
I
TGPNTGG
K
T
I
M
L
K
T
L
G
L
A
Q
L
MGQSGL
P
V
LADKG
S
K
I
A
V
F
N
N
I
F
ADIG
D
E
Q
S
I
E
Q
S
L
S
T
F
S
S
H
M
T
H
I
V
S
I
L
N
E-ADHN
S
L
V
L
F
DELGAGT
D
P
Q
E
G
A
S
L
A
M
A
I
L
E
H
L
R
L-S-NI
K
--
T
M
ATTHYPE
L
K
A
Y-GIET
N
-
F
VENASMEF--D--AETL
S
P
T
--
Y
R
F
M
Q----GVPGR
S
N
A
F
E
I
A
S
RLGL
A
P
F
I
V
K
Q
A
-
K
QMTDS
D
S
D
V
N
R
I
I
E
Q
L
E
A
Q
T
L
E
T
R
R
R
L
D
H
I
K
E
I
E
Q
EN
L
K
F
N
R
A
V
K
K
L
Y
N
E
FS
H
E
R
D
K
E
L
E
K
I
Y
Q
E
A
Q
E
I
V
D
M
ALNE
S
D
T
I
L
K
KLN
D
K
SQL
K
P
H
E
I
I
D
A
K
A
Q
I
K
K
LAPQVDL
S
K
N
K
V
L
N
K
A
K
K
I
K
AARAPRIGD
D
I
I
V
T
SYGQRGT
L
T
S
Q
LKDGR
W
E
A
Q
V
G
I
I
K
M
T
LTQD
E
F
T
L
V
R
V
Q
E
E
QKVKSKQ
I
N
V
V
K
KADSSGP
R
A
R
L
DLR
G
K
R
Y
E
E
A
M
Q
E
L
D
N
F
I
D
Q
A
L
L
NNMGQ
V
D
I
I
HGI
G
T
G
V
I
R
E
G
V
T
K
Y
L
R
RNKHV
K
H
F
AYAPQNAGGS
G
A
T
I
V
TLG
38
HHSearch
89.50
21%
-67
- C2 -
3THX
3
MSH3_HUMAN
B:
[321-875]
I
N
G
T
T
L
R
N
L
E
I
L
Q
------
N
QTDMKTKGS
L
L
W
V
L
D
H
T
K
T
S
F
G
R
R
K
L
K
K
W
V
T
Q
P
L
L
K
L
R
E
I
N
A
R
L
D
A
V
S
E
V
L
H
S
E
SS
V
F
G
Q
I
E
-
N
H
L
R
K
L
P
D
I
E
R
G
L
C
S
I
Y
-
H
K
K
C
S
T
Q
E
F
F
L
I
V
K
T
L
Y
H
L
K
S
E
F
Q
A
I
I
P
A
V
N
S
H
I
Q
S
D
-
L
L
R
T
----
V
I
L
E
I
P
E
L
L
S
P
V
E
H
Y
L
K
I
L
N
--------
E
--------
Q
A
A
K
V
GDK
T
E
L
F
K
D
L
S
D
F
P
L
I
K
K
R
K
D
E
I
Q
G
V
I
D
E
I
R
M
H
L
Q
E
I
R
K
I
L
-----
K
N
P
S
A
Q
Y
V
T
V
S
G
Q
E
F
M
I
E
I
K
N
S
A
V
S
C
I
P
T
D
W
V
K
V
G
S
T
K
A
V
S
R
F
H
S
P
F
I
V
E
N
Y
R
H
L
N
Q
L
R
E
Q
L
V
L
D
C
S
A
E
W
L
D
F
L
E
K
F
S
E
H
Y
H
S
L
C
K
A
V
H
H
L
A
T
V
D
C
I
-----
F
S
L
A
K
V
A
K
Q
--
G
D
Y
C
R
P
T
V
------
Q
E
E
--
R
K
I
V
I
K
N
G
R
H
P
V
----
I
---
D
V
L
LGEQD
Q
Y
-----
V
P
N
N
T
D
L
S
-
E
D
S
E
R
V
M
-
I
I
T
G
P
N
M
G
G
K
S
S
Y
I
K
Q
V
A
L
I
T
I
M
A
Q
I
G
S
Y
V
P
A
E
E
-
A
T
I
G
I
V
D
G
I
F
T
R
M
----------
S
T
F
M
E
E
L
T
D
T
A
E
I
I
R
K
-
A
T
S
Q
S
L
V
I
L
D
E
L
G
R
G
T
S
T
H
D
G
I
A
I
A
Y
A
T
L
E
Y
F
I
R
D
V
-
K
S
L
--
T
L
F
V
T
H
Y
P
P
V
C
E
L
-
E
K
N
Y
S
H
Q
V
G
N
Y
H
M
G
F
--
L
VS---
V
T
F
L
--
Y
Q
I
T
R
----
G
I
A
A
R
S
Y
G
L
N
V
A
K
L
A
D
V
P
G
E
I
L
K
K
A
A
H
K
S
K
E
L
E
G
L
I
N
T
K
R
K
R
L
K
Y
F
A
K
L
W
T
M
H
N
A
Q
D
L
Q
K
W
T
E
E
F
N
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
86.08
20%
-62
- C2 -
3THX
3
MSH2_HUMAN
A:
[302-849]
L
D
I
A
A
V
R
A
L
N
L
F
Q
-------QS-------
L
A
A
L
L
N
K
C
K
T
P
Q
G
Q
R
L
V
N
Q
W
I
K
Q
P
L
M
D
K
N
R
I
E
E
R
L
N
L
V
E
A
F
V
E
D
A
E
L
-
R
Q
T
L
Q
E
D
L
L
R
R
F
P
D
L
N
R
L
A
K
K
F
Q
R
-
Q
A
A
N
L
Q
D
C
Y
R
L
Y
Q
G
I
N
Q
L
P
N
V
I
Q
A
L
-
E
K
H
E
G
-
K
H
Q
K
L
L
L
A
V
F
V
T
P
L
T
D
L
R
S
D
F
S
K
F
Q
E
M
I
E
T
T
L
D
--------
M
--------
D
QVENH
E
-
F
L
V
-
K
P
-
S
F
D
P
N
L
S
E
L
R
E
I
M
N
D
L
E
K
K
M
Q
S
T
L
I
S
A
A
R
D
L
G
LDPG
K
Q
I
K
L
D
S
S
A
--
G
Y
Y
F
R
V
T
C
K
E
E
K
V
L
R
N
N
K
N
F
S
T
V
D
I
Q
--
G
V
K
F
T
N
S
K
L
T
S
L
N
E
E
Y
T
K
N
K
T
E
Y
E
E
A
Q
D
A
I
V
K
E
I
V
N
I
S
S
G
Y
V
E
P
M
Q
T
L
N
D
V
L
A
Q
L
D
A
V
-----
V
S
F
A
H
V
S
N
G
AP
V
P
Y
V
R
P
A
I
------
L
E
K
GQ
G
R
I
I
L
K
A
S
R
H
A
C
----
V
---
E
VQI----
A
F
-----
I
P
N
D
V
Y
F
E
K
D
-
K
Q
M
F
H
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
I
V
L
M
A
Q
I
G
C
F
V
P
C
E
S
-
A
E
V
S
I
V
D
C
I
L
A
R
V
G
---------
S
T
F
M
A
E
M
L
E
T
A
S
I
L
R
S
-
A
T
K
D
S
L
I
I
I
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
W
A
I
S
E
Y
I
A
T
-
K
I
G
A
F
--
C
M
F
A
T
H
F
H
E
L
T
A
L
-
A
N
Q
I
P
-
T
V
N
N
L
H
V
T
A
--
L
T
T
E
E
T
L
T
M
L
--
Y
Q
V
K
K
----
G
V
C
D
Q
S
F
G
I
H
V
A
E
L
A
N
F
P
K
H
V
I
E
C
A
K
Q
K
A
L
E
L
E
E
F
Q
Y
K
C
Y
L
E
R
E
Q
G
E
K
I
I
Q
E
F
L
S
K
V
K
Q
M
P
F
T
E
M
S
E
E
N
I
T
I
K
L
K
Q
L
K
A
E
V
I
A
K
N
N
S
F
V
N
E
I
I
S
R
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
84.74
21%
-70
- C2 -
1WB9
4
MUTS_ECOLI
A:
[269-794]
M
D
A
A
T
R
R
N
L
E
I
T
Q
------
N
LAGGAENT-
L
A
S
V
L
D
C
T
V
T
P
M
G
S
R
M
L
K
R
W
L
H
M
P
V
R
D
T
R
V
L
L
E
R
Q
Q
T
I
G
A
L
Q
D
F
T
----
A
G
L
Q
-
P
V
L
R
Q
V
G
D
L
E
R
I
L
A
R
L
A
L
-
R
T
A
R
P
R
D
L
A
R
M
R
H
A
F
Q
Q
L
P
E
L
R
A
Q
L
-
E
T
V
D
----
S
A
-
P
V
Q
A
----
L
R
E
K
M
G
E
F
A
E
L
R
D
L
L
E
R
A
I
I
--------
D
TPPVLVRD
G
-------
G
V
I
-
A
S
-
G
Y
N
E
E
L
D
E
W
R
A
L
A
D
G
A
T
D
Y
L
E
R
L
E
V
R
E
R
E
R
T
G
L---
D
T
L
K
V
G
F
N
--
A
V
H
G
Y
Y
I
Q
I
S
R
G
Q
S
H
L
A
P
I
N
Y
M
R
R
Q
T
L
K
N
A
E
R
Y
I
I
P
E
L
K
E
Y
E
D
K
V
L
T
S
K
G
K
A
L
A
L
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
-----
V
N
L
A
E
R
A
Y
T
--
L
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
----
V
---
E
Q
V
LN
E
--
P
F
-----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
N
-
K
I
K
A
L
--
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
V
H
L
D
A
--
L
E
H
G
D
T
I
A
F
M
--
H
S
V
Q
D
----
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
R
Q
K
L
R
E
L
E
S
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
83.78
22%
-60
- C2 -
1EWQ
5
MUTS_THEAQ
A:
[252-760]
L
P
E
A
T
L
R
A
L
E
V
F
E
PLRGQD
T
---------
L
F
S
V
L
D
E
T
R
T
A
P
G
R
R
L
L
Q
S
W
L
R
H
P
L
L
D
R
G
P
L
E
A
R
L
D
R
V
E
G
F
V
R
E
G
A
L
-
R
E
G
V
R
-
R
L
L
Y
R
L
A
D
L
E
R
L
A
T
R
L
E
L
-
G
R
A
S
P
K
D
L
G
A
L
R
R
S
L
Q
I
L
P
E
L
R
A
L
L
-
G
E
E
V
---
G
---------------
L
P
D
L
S
P
L
K
E
E
L
E
A
A
L
V
EDPPLKVS
E
--------
G
-------
G
L
I
-
R
E
-
G
Y
D
P
D
L
D
A
L
R
A
A
H
R
E
G
V
A
Y
F
L
E
L
E
E
R
E
R
E
R
T
G
I---
P
T
L
K
V
G
Y
--
N
A
V
F
G
Y
Y
L
E
V
T
R
P
Y
Y
E
R
V
P
K
E
Y
R
P
V
Q
T
L
K
D
R
Q
R
Y
T
L
P
E
M
K
E
K
E
R
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
-----
A
A
L
A
E
V
A
V
R
--
Y
G
Y
V
R
P
R
F
------
G
D
----
R
L
Q
I
R
A
G
R
H
P
V
----
V
---
E
R
R
T----
E
F
-----
V
P
N
D
L
E
M
A
----
H
E
L
V
-
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
-
E
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
-
L
I
L
K
E
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
-
R
-
R
A
Y
--
T
L
F
A
T
H
Y
F
E
L
T
A
L
G
L
P
R
L
K
-
N
L
---
H
V
A
A
R
E
E
--
A
G
G
L
V
F
Y
--
H
Q
V
L
P
----
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
R
A
L
L
Q
A
M
A
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.02
31%
-65
- C2 -
1W7A
2
MUTS_ECOLI
B:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
D
--
S
G
R
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.34
31%
-66
- C2 -
2WTU
1
MUTS_ECOLI
B:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
A
A
D
D
L
A
S
G
R
S
T
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.62
26%
-63
- C2 -
2O8D
4
MSH2_HUMAN
A:
[534-846]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
N
K
N
F
S
T
V
D
I
Q
K
N
G
--
V
K
F
T
N
S
K
L
T
S
L
N
E
E
Y
T
K
N
K
T
E
Y
E
E
A
Q
D
A
I
V
K
E
I
V
N
I
S
S
G
Y
V
E
P
M
Q
T
L
N
D
V
L
A
Q
L
D
A
V
------
V
S
F
A
H
V
S
---
N
G
A
P
V
P
Y
V
R
P
AILE
K
G
Q
--
G
R
I
I
L
K
A
S
R
H
A
C
----
V
---
E
-------
V
Q
DEIA
F
I
P
N
D
V
Y
F
E
-
K
-
D
K
Q
M
F
H
I
I
T
G
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
I
V
L
M
A
Q
I
G
C
F
V
P
C
E
-
S
A
E
V
S
I
V
D
C
I
L
A
R
V
G
---------
S
T
F
M
A
E
M
L
E
T
A
S
I
L
R
S
-
A
T
K
D
S
L
I
I
I
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
W
A
I
S
E
Y
I
A
T
-
K
I
G
A
F
--
C
M
F
A
T
H
F
H
E
L
T
A
L
-
A
N
Q
I
P
-
T
V
N
N
L
H
V
T
A
--
L
--
T
T
E
E
T
L
T
M
L
Y
Q
V
K
K
----
G
V
C
D
Q
S
F
G
I
H
V
A
E
L
A
N
F
P
K
H
V
I
E
C
A
-
K
Q
K
A
L
E
L
E
E
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.41
26%
-68
- C2 -
2O8E
4
MSH2_HUMAN
A:
[534-846]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
N
K
N
F
S
T
V
D
I
Q
K
N
G
--
V
K
F
T
N
S
K
L
T
S
L
N
E
E
Y
T
K
N
K
T
E
Y
E
E
A
Q
D
A
I
V
K
E
I
V
N
I
S
S
G
Y
V
E
P
M
Q
T
L
N
D
V
L
A
Q
L
D
A
V
------
V
S
F
A
H
V
S
---
N
G
A
P
V
P
Y
V
R
P
A
I
L
E
K
G
Q
--
G
R
I
I
L
K
A
S
R
H
A
C
----
V
---
E
-------
V
Q
DEIA
F
I
P
N
D
V
Y
F
E
-
K
-
D
K
Q
M
F
H
I
I
T
G
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
I
V
L
M
A
Q
I
G
C
F
V
P
C
E
-
S
A
E
V
S
I
V
D
C
I
L
A
R
V
G
---------
S
T
F
M
A
E
M
L
E
T
A
S
I
L
R
S
-
A
T
K
D
S
L
I
I
I
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
W
A
I
S
E
Y
I
A
T
-
K
I
G
A
F
--
C
M
F
A
T
H
F
H
E
L
T
A
L
-
A
N
Q
I
P
-
T
V
N
N
L
H
V
T
A
--
L
--
T
T
E
E
T
L
T
M
L
Y
Q
V
K
K
----
G
V
C
D
Q
S
F
G
I
H
V
A
E
L
A
N
F
P
K
H
V
I
E
C
A
-
K
Q
K
A
L
E
L
E
E
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.29
31%
-76
- C2 -
3ZLJ
-
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
-------------
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.15
28%
-60
- C2 -
1NNE
5
MUTS_THEAQ
A:
[487-761]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
-----
A
A
L
A
E
V
A
V
R
--
Y
G
Y
V
R
P
R
F
------
G
D
----
R
L
Q
I
R
A
G
R
H
P
V
----
V
E
R
R
T
-------
E
F
-----
V
P
N
D
L
E
M
A
-
H
-
E
L
--
V
-
L
I
T
G
P
N
M
A
G
K
S
T
F
L
R
Q
T
A
L
I
A
L
L
A
Q
V
G
S
F
V
P
A
E
E
-
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
F
M
V
E
M
E
E
V
A
L
I
L
K
E
-
A
T
E
N
S
L
V
L
L
D
E
V
G
R
G
T
S
S
L
D
G
V
A
I
A
T
A
V
A
E
A
L
H
E
-
R
-
R
A
Y
--
T
L
F
A
T
H
Y
F
E
L
T
A
L
-
G
L
P
R
L
-
K
N
L
H
V
A
A
R
E
--
E
--
A
G
G
L
V
F
Y
--
H
Q
V
L
P
----
G
P
A
S
K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
-
R
A
L
L
Q
A
M
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.03
26%
-63
- C2 -
2O8F
4
MSH2_HUMAN
A:
[534-846]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
N
K
N
F
S
T
V
D
I
Q
K
N
G
--
V
K
F
T
N
S
K
L
T
S
L
N
E
E
Y
T
K
N
K
T
E
Y
E
E
A
Q
D
A
I
V
K
E
I
V
N
I
S
S
G
Y
V
E
P
M
Q
T
L
N
D
V
L
A
Q
L
D
A
V
------
V
S
F
A
H
V
S
---
N
G
A
P
V
P
Y
V
R
P
A
I
L
E
K
G
Q
--
G
R
I
I
L
K
A
S
R
H
A
C
----
V
---
E
-------
V
Q
DEIA
F
I
P
N
D
V
Y
F
E
-
K
-
D
K
Q
M
F
H
I
I
T
G
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
I
V
L
M
A
Q
I
G
C
F
V
P
C
E
-
S
A
E
V
S
I
V
D
C
I
L
A
R
V
G
---------
S
T
F
M
A
E
M
L
E
T
A
S
I
L
R
S
-
A
T
K
D
S
L
I
I
I
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
W
A
I
S
E
Y
I
A
T
-
K
I
G
A
F
--
C
M
F
A
T
H
F
H
E
L
T
A
L
-
A
N
Q
I
P
-
T
V
N
N
L
H
V
T
A
--
L
--
T
T
E
E
T
L
T
M
L
Y
Q
V
K
K
----
G
V
C
D
Q
S
F
G
I
H
V
A
E
L
A
N
F
P
K
H
V
I
E
C
A
-
K
Q
K
A
L
E
L
E
E
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.92
31%
-69
- C2 -
1WBD
2
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.61
31%
-70
- C2 -
1WBB
2
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.46
31%
-68
- C2 -
1WB9
2
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.42
26%
-61
- C2 -
2O8B
4
MSH2_HUMAN
A:
[534-846]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
N
K
N
F
S
T
V
D
I
Q
K
N
G
--
V
K
F
T
N
S
K
L
T
S
L
N
E
E
Y
T
K
N
K
T
E
Y
E
E
A
Q
D
A
I
V
K
E
I
V
N
I
S
S
G
Y
V
E
P
M
Q
T
L
N
D
V
L
A
Q
L
D
A
V
------
V
S
F
A
H
V
S
---
N
G
A
P
V
P
Y
V
R
P
A
I
L
E
K
G
Q
--
G
R
I
I
L
K
A
S
R
H
A
C
----
V
---
E
-------
V
Q
DEIA
F
I
P
N
D
V
Y
F
E
-
K
-
D
K
Q
M
F
H
I
I
T
G
P
N
M
G
G
K
S
T
Y
I
R
Q
T
G
V
I
V
L
M
A
Q
I
G
C
F
V
P
C
E
-
S
A
E
V
S
I
V
D
C
I
L
A
R
V
G
---------
S
T
F
M
A
E
M
L
E
T
A
S
I
L
R
S
-
A
T
K
D
S
L
I
I
I
D
E
L
G
R
G
T
S
T
Y
D
G
F
G
L
A
W
A
I
S
E
Y
I
A
T
-
K
I
G
A
F
--
C
M
F
A
T
H
F
H
E
L
T
A
L
-
A
N
Q
I
P
-
T
V
N
N
L
H
V
T
A
--
L
--
T
T
E
E
T
L
T
M
L
Y
Q
V
K
K
----
G
V
C
D
Q
S
F
G
I
H
V
A
E
L
A
N
F
P
K
H
V
I
E
C
A
-
K
Q
K
A
L
E
L
E
E
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.96
31%
-70
- C2 -
1OH8
2
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
VEQV
L
---
N
-------
E
P
F----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
A
L
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.71
31%
-68
- C2 -
1OH6
2
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.66
29%
-75
- C2 -
1E3M
2
MUTS_ECOLI
A:
[524-791]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
G
-----------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
D
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
-
A
-
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
V
H
L
D
A
L
E
H
--
G
D
T
I
A
F
M
--
H
S
V
Q
D
----
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.64
31%
-73
- C2 -
3K0S
1
MUTS_ECOLI
A:
[523-790]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Q
L
Y
E
E
L
F
D
L
L
L
P
H
L
E
A
L
Q
Q
S
A
S
A
L
A
E
L
D
V
L
V
N
L
A
E
R
A
Y
T
L
-------
N
Y
T
C
P
T
F
------
I
D
K
--
P
G
I
R
I
T
E
G
R
H
P
V
V
E
Q
V
L
---
N
-------
E
P
F
----
I
A
N
P
L
N
L
S
-
P
-
Q
R
R
M
L
-
I
I
T
G
P
N
M
G
G
K
S
T
Y
M
R
Q
T
A
L
I
A
L
M
A
Y
I
G
S
Y
V
P
A
Q
K
-
V
E
I
G
P
I
D
R
I
F
T
R
V
------------
F
M
V
E
M
T
E
T
A
N
I
L
H
N
-
A
T
E
Y
S
L
V
L
M
N
E
I
G
R
G
T
S
T
Y
D
G
L
S
L
A
W
A
C
A
E
N
L
A
--
N
-
K
I
K
AL
T
L
F
A
T
H
Y
F
E
L
T
Q
L
-
P
E
K
M
E
-
G
V
A
N
--
V
H
L
--
D
--
A
L
E
H
G
D
T
--
I
A
F
M
H
S
V
Q
D
G
A
A
S
K
S
Y
G
L
A
V
A
A
L
A
G
V
P
K
E
V
I
K
R
A
-
R
Q
K
L
R
E
L
E
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.62
29%
-62
- C2 -
1FW6
6
MUTS_THEAQ
A:
[487-752]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Y
R
L
E
A
L
I
R
R
R
E
E
E
V
F
L
E
V
R
E
R
A
K
R
Q
A
E
A
L
R
E
A
A
R
I
L
A
E
L
D
V
Y
-----
A
A
L
A
E
V
A
V
R
--
Y
G
Y
V
R
P
R
F
------
G
D
----
R
L
Q
I
R
A
G
R
H
P
V
----
V
E
R
R
T
-------
E
F
-----
V
P
N
D
L
E
M
A
-
H
-
E
L
--
V
-
L
I
T
G
P
N
M
A
G
K
S
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L
R
Q
T
A
L
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A
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L
A
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V
G
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F
V
P
A
E
E
-
A
H
L
P
L
F
D
G
I
Y
T
R
I
G
A
------
G
K
S
T
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M
V
E
M
E
E
V
A
L
I
L
K
E
-
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T
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N
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L
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L
L
D
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G
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G
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D
G
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A
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A
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H
E
-
R
-
R
A
Y
--
T
L
F
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Y
F
E
L
T
A
L
-
G
L
P
R
L
-
K
N
L
H
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A
A
R
E
--
E
--
A
G
G
L
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F
Y
--
H
Q
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L
P
----
G
P
A
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K
S
Y
G
V
E
V
A
A
M
A
G
L
P
K
E
V
V
A
R
A
-
R
A
L
L
Q
A
M
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------