@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1772: (2015-12-10 )
MATVKTNTDIFEQAWEGFKGVDWKEKASIARFVQANYAPYDGDESFLAGATERSLHIKKVIEETKAHYEETRFPMDTRVASISELPAGFIDKDSELIFGIQNDELFKLNFMPKGGIRMAETTLKENGYEPDPAVHEIFTKYATTVNDGIFRAYTSNIRRARHAHTVTGLPDAYSRGRIIGVYARLAVYGADYLMQEKVNDWNALNDIDEESIRLREEINLQYQALGEVVKLGDLYGVDVRKPAMNTKEAIQWVNIAFMAVCRVINGAATSLGRVPIVLDIFAERDLARGTFTESEIQEFVDDFVLKLRTVKFARTKAYDALYSGDPTFITTSMAGMGADGRHRVTKMDYRFLNTLDNIGNSPEPNLTVLWSDQLPYAFRRYCMSMSHKHSSIQYEGVSTMAKEGYGEMSCISCCVSPLDPENEDKRHNLQYFGARVNVMKALLTGLNGGYDDVHKDYKVFDIDPIRDEVLNFDTVKANFEKSLDWLTDTYVDAMNIIHYMTDKYNYEAVQMAFLPSHVRANMGFGICGFANTVDSLSAIKYATVKPIRDEDGYIYDYETVGDFPRYGEDDDRVDSIAEWLLEAFHGRLAKHKLYKDAEATVSLLTITSNVAYSKQTGNSPVHKGVYLNEDGSVNLSKVEFFSPGANPSNKAKGGWLQNLNSLSKLDFAHANDGISLTTQVSPRALGKTFDEQVDNLVTVLDGYFENGGQHVNLNVMDLKDVYDKIMNGEDVIVRISGYCVNTKYLTPEQKTELTQRVFHEVLSMDDALTN
Atome Classification :
(20 SA)
---------------------------------.........10........20.....---...30........40........50......-..60.......--.70..-----.---..--.--..---------80-....--------....90........100.......110.......120...------..----------..130...-----....140.-.......150........160----.....-...170..-.....180.......190.......200..---.--------.---------..------.210.-------......220--........230.......240....---------------------------...250.......260--........270.......280.......290.......300.......310.......320.......330.......340.......350.......360----.......370....-...380......---.390....-----...400.-..--------....--------------410.......420........430........440.......450.......460.......470.......480.......490.......500.......510...----....------------520.----------..--.--.---------..530-----........540-------.......550-------.-----........-------560.......570.......580.....-..590.......600.......610.......620.......---630.......640.......-650-........660.......670.......680.......690.......700...-----.-----...710.......720.......---730--.........740.......750.......760.......770-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------MATVKT
N
T
D
I
F
E
Q
A
W
E
GFKGV
D
W
K
E
K
---
A
S
I
A
R
F
V
Q
ANYAPYDGD
E
S
F
LAGATER
S
L
H
I
-
K
K
V
I
E
E
T
K
A
H
Y
--
E
ETRF-----P---M
D
--
T
--
R
V
---------
A
S
-
I
S
EL--------PAGFIDKDS
E
L
I
F
G
IQN
D
E
L
F
K
L
N
F
MPKGGI
R
M
A
E
T
T
L
KE------NG----------YEPD
P
A
V
H
-----
E
I
F
T
K
Y
-
A
-
T
TVND
G
I
F
-
R
A
Y
T
S
N
I
R
R
A
R-----HAHTV-TGLPDAYS-R
G
R
I
I
G
V
Y
A
R
L
A
V
Y
G
A
D
Y
L
M
Q
E
KVNDWNAL---N--------D---------I
D
------
E
E
S
I
R
-------
L
R
E
E
I
N
L
Q
---
Y
Q
A
L
G
E
V
V
K
L
G
D
L
Y
G
V
DVRKPAM
N
T
---------------------------
K
E
A
I
Q
W
V
N
I
A
F
M
A
V
C
---
R
V
I
N
GAATSLGRV
P
I
V
L
D
IFAERDLARGTF
T
E
S
E
I
Q
E
F
V
D
D
F
V
L
K
L
R
T
V
K
F
A
RTKAYDALYSGDP
T
F
I
T
TSMAGMGADGRH
R
V
T
K
M
D
Y
R
F
L
N
T
L
D
NIGNSP----EP
N
L
T
V
L
WSDQL
P
Y
-
A
F
R
R
Y
C
M
S
MSHK---HS
S
I
Q
YE
G
-----
V
S
T
M
A
K
E-GY--------G
E
M
S
--------------
C
I
S
C
CVSPLDP-ENEDKRH
N
L
Q
Y
-
F
G
A
R
V
N
V
M
K
A
L
L
T
GLNG
G
Y
D
D
V
HKDYKVFDIDP
I
R
D
E
VLNF
D
T
V
K
A
N
F
E
K
S
L
D
W
L
T
D
T
Y
V
D
A
M
N
I
I
H
Y
MTDKYN
Y
E
A
V
Q
M
A
F
L
P
----
S
H
V
R
------------ANMG----------FG--I--C---------GFA
N
------
T
V
D
S
L
S
A
I
K
Y
A
-------TVKPIRDE---------D-----G
Y
I
Y
D
Y
E
T-------VGDFPRYGED
D
D
R
V
D
S
I
A
E
W
L
L
E
A
F
H
G
R
-
L
A
K
H
K
L
YKDAE
A
T
V
S
L
L
T
I
TSN
V
A
YSKQTGNSPVHK
G
V
Y
LNE---DGS
V
N
L
S
K
V
E
F
FSPGANPSN-K-A-KG
G
W
L
Q
N
L
N
S
L
S
K
LDFAHAND
G
I
S
L
T
T
QVS
P
R
A
LG
K
T
F
D
E
Q
V
D
N
L
V
T
V
L
D
G
Y
F
E-----N-----G
G
Q
H
V
N
L
N
V
M
D
L
K
D
V
Y
D
K
IMNG
E
---
D
----
V
I
V
R
I
S
G
Y
C
VN
T
K
YLT
P
E
Q
K
T
E
L
T
Q
R
V
F
H
E
V
L
S
M
DDALTN---
36
Fugue
94.62
44%
-66
- C4 -
1CM5
2
PFLB_ECOLI
A:
[1-759]
-------------------------------------
S
E
L
N
E
K
L
A
T
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
-
W
D
K
V
M
E
G
V
K
L
E
--
N
R
T
H
A
-----
P
VDF
D
T
--
A
--
V
A
---------
S
T
-
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
--------
A
---------
D
L
E
N
GVN
L
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
A
A
V
S
P
M
I
V
-
G
K
-----
Q
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
-
G
-
R
D
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
26
HHSearch
94.50
45%
-69
- C4 -
1H16
13
PFLB_ECOLI
A:
[2-759]
--------------------------------------
E
L
N
E
K
L
A
T
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
-
W
D
K
V
M
E
G
V
K
L
E
N
R
T
H
A
P
V
-----
D
---
F
D
--
T
A-
V
A
---------
S
T
-
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
D
L
E
N
---
G
V--------
N
L
------
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
---
I
V
---
G
K
Q
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
D
G
---------------
R
R
A
G
A
P
F
G
P
G
A
N
P
M
H
-
G
R
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
HEASI
E
-----
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
---
K
YPQ-
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
7
PsiBlast_PDB
94.14
44%
-67
- C4 -
1CM5
2
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
A
A
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
2
PsiBlast_PDB
94.10
44%
-68
- C4 -
3PFL
1
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
1
PsiBlast_PDB
94.05
44%
-69
- C4 -
2PFL
1
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
3
PsiBlast_PDB
93.99
44%
-67
- C4 -
1H16
13
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
5
PsiBlast_PDB
93.96
44%
-67
- C4 -
1H18
11
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
25
PsiBlast_CBE
93.73
44%
-67
- C4 -
1CM5
2
PFLB_ECOLI
B:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A-------
D
---------
L
E
NGVNL-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
A
A
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
21
PsiBlast_CBE
93.70
44%
-68
- C4 -
3PFL
1
PFLB_ECOLI
B:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A-------
D
---------
L
E
NGVNL-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
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T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
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T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
22
PsiBlast_CBE
93.63
44%
-69
- C4 -
2PFL
2
PFLB_ECOLI
B:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A-------
D
---------
L
E
NGVNL-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
4
PsiBlast_PDB
93.57
44%
-68
- C4 -
1H17
13
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
24
PsiBlast_CBE
93.34
44%
-67
- C4 -
1H18
10
PFLB_ECOLI
B:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A-------
D
---------
L
E
NGVNL-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
6
PsiBlast_PDB
93.26
44%
-67
- C4 -
1MZO
2
PFLB_ECOLI
A:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
23
PsiBlast_CBE
93.18
44%
-67
- C4 -
1MZO
1
PFLB_ECOLI
B:
[10-759]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A-------
D
---------
L
E
NGVNL-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
T
G
N
T
P
------------
D
G
R
R
A
G
A
P
---
F
G
P
G
A
N
P
M
H
G
R
-
D
-
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
R
E
M
L
L
D
A
M
E
N
P
E
KYP
Q
----
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
37
Fugue
92.63
42%
-74
* C4 *
3PFL
1
PFLB_ECOLI
A:
[1-759]
-------------------------------------
S
E
L
N
E
K
L
A
T
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
-
W
D
K
V
M
E
G
V
K
L
E
--
N
R
T
H
A
-----
P
VDF
D
T
--
A
--
V
A
---------
S
T
-
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
K
S
GVL
T
G
L
P
D
-
A
Y
-----
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
--------
A
---------
D
L
E
N
GVN
L
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
----GPSP
E
P
N
M
T
I
L
W
S
E
K
L
P
-
L
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
F
N
N
---------
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
G------
K
Q
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
--
Y
S
Y
E
A
S
L
M
A
-
L
HDR-
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
-
S
N
V
V
Y
G
K
K
T
G
----
N
T
P
D
G
R
R
---
A
G
-------
A
P
F
G
P
G
A
N
P
M
H
-
G
-
R
D
Q
K
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
-----
H
EASIE
G
G
Q
H
L
N
V
N
V
M
N
-
R
E
M
L
L
D
A
M
E
N
P
---
E
KYPQ
L
T
I
R
V
S
G
Y
A
V
R
F
N
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
-----------
8
PsiBlast_PDB
82.88
47%
-45
- C- -
1QHM
-
PFLB_ECOLI
A:
[1010-1615]
----------------------------------------------
A
W
E
G
F
T
K
G
D
W
Q
N
E
---
V
N
V
R
D
F
I
Q
K
N
Y
T
P
Y
E
G
D
E
S
F
L
A
G
A
T
E
A
T
T
T
L
W
D
K
V
M
E
G
V
K
L
E
---
N
R
T
H
A
-----
P
---
V
D
FD
T
--
A
V
---------
A
S
T
I
T
S
H
--------
D
A
G
Y
I
N
K
Q
L
E
K
I
V
G
L
Q
T
E
A
P
L
K
R
A
L
I
P
F
G
G
I
K
M
I
E
G
S
C
K
A
------
Y
N
----------
R
E
L
D
P
M
I
K
-----
K
I
F
T
E
Y
-
R
-
K
T
H
N
Q
G
V
F
-
D
V
Y
T
P
D
I
L
R
C
R
-----
K
S
G
V
L
-
T
G
L
P
D
A
Y
G
-
R
G
R
I
I
G
D
Y
R
R
V
A
L
Y
G
I
D
Y
L
M
K
D
K
L
A
Q
F
T
S
L
---
Q
A
-------
D
---------
L
E
N
GVN
L
-
E
Q
T
I
R
-------
L
R
E
E
I
A
E
Q
---
H
R
A
L
G
Q
M
K
E
M
A
A
K
Y
G
Y
D
I
S
G
P
A
T
N
A
---------------------------
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
---
K
S
Q
N
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
K
I
T
E
Q
E
A
Q
E
M
V
D
H
L
V
M
K
L
R
M
V
R
F
L
R
T
P
E
Y
D
E
L
F
S
G
D
P
I
W
A
T
E
S
I
G
G
M
G
L
D
G
R
T
L
V
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
P
S
P
----
E
P
N
M
T
I
L
W
S
E
K
L
P
L
-
N
F
K
K
F
A
A
K
V
S
I
D
---
T
S
S
L
Q
Y
E
N
-----
D
D
L
M
R
P
D
-
F
N
--------
N
D
D
Y
--------------
A
I
A
C
C
V
S
P
M
I
V
-
G
K
Q
-----
M
Q
F
-
F
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
G
G
V
D
E
K
L
K
M
Q
V
G
P
K
S
E
P
I
K
G
D
V
L
N
Y
D
E
V
M
E
R
M
D
H
F
M
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
Y
E
A
S
L
M
A
L
H
D
----
R
D
V
I
------------
R
T
M
A
----------
C
G
--
I
--
A
---------
G
L
S
V
------
A
A
D
S
L
S
A
I
K
Y
A
-------
K
V
K
P
I
R
D
E
---------
D
-----
G
L
A
I
D
F
E
I
-------
E
G
E
Y
P
Q
F
G
N
N
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
-
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
N
V
V
Y
G
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
73.12
19%
-43
- C4 -
1R9D
1
?
A:
[2-787]
--------------------------------I
S
K
G
F
S
T
Q
T
E
R
I
N
I
L
K
A
Q
I
L
N
A
K
P
C
V
E
---
S
E
R
A
I
L
I
T
E
S
F
K
Q
T
E
G
Q
P
----
A
I
L
R
R
A
L
A
L
-
K
H
I
L
E
N
I
P
I
T
I
-------------------------------------------------------
R
D
Q
E
L
I
V
G
S
L
T
K
E
P
R
S
S
Q
V
F
P
E
F
S
N
K
W
L
Q
D
E
L
D
R
------
L
N
KRTGD
A
F
Q
I
S
E
E
S
K
E
K
L
K
-----
D
V
F
E
Y
W
-
N
G
K
T
T
S
E
L
A
T
-
S
Y
M
T
E
E
T
R
E
A
V
-----
N
C
D
V
F
-
T
V
G
N
Y
Y
Y
N
G
V
G
H
V
S
V
D
Y
G
K
V
L
R
V
G
F
N
G
I
I
N
E
A
K
E
Q
L
E
K
N
---
R
--------
S
---------
I
D
------
P
D
F
I
K
-------
K
E
K
F
L
N
S
V
---
I
I
S
C
E
A
A
I
T
Y
V
N
R
Y
A
K
K
A
K
E
I
A
D
N
T
SD
A
K
R
K
A
E
L
N
E
I
A
K
I
C
S
K
V
S
G
E
G
A
K
S
F
Y
E
A
C
Q
L
F
W
F
I
H
A
I
I
N
---
I
E
S
N
G
H
S
I
S
P
A
R
F
D
Q
Y
M
Y
P
Y
Y
E
N
D
---
K
N
I
T
D
K
F
A
Q
E
L
I
D
C
I
W
I
K
L
N
D
I
N
K
V
R
D
E
I
S
T
K
H
F
G
G
Y
P
M
Y
Q
N
L
I
V
G
G
Q
N
S
E
G
K
D
A
T
N
K
V
S
Y
M
A
L
E
A
A
V
H
V
-
K
L
P
----
Q
P
S
L
S
V
R
I
W
N
K
T
P
D
-
E
F
L
L
R
A
A
E
L
T
R
E
---
G
L
G
L
P
A
Y
Y
N
D
E
V
I
I
P
A
L
V
S
R
-
G
L
--------
T
L
E
D
--------------
A
R
D
Y
G
I
I
G
C
V
E
-
P
Q
K
P
G
K
T
E
G
W
H
-
D
S
A
F
F
N
L
A
R
I
V
E
L
T
I
N
S
G
F
D
---
K
N
K
Q
I
G
P
K
T
Q
N
F
E
E
M
K
S
F
D
E
F
M
K
A
Y
K
A
Q
M
E
Y
F
V
K
H
M
C
C
A
D
N
C
I
D
I
A
H
A
E
R
A
P
L
P
F
L
S
S
M
V
D
----
N
C
I
G
KGKSLQDGGAE
Y
N
F
S
G
----------
P
Q
--
G
--
V
---------
G
V
A
N
------
I
G
D
S
L
V
A
V
K
K
I
VFDENKI
T
P
S
E
L
K
K
T
L
N
N
DF----
K
-----
N
S
E
E
I
Q
A
L
-------
L
K
N
A
P
K
F
G
N
D
I
D
E
V
D
N
L
A
R
E
G
A
L
V
Y
C
R
E
-
V
N
K
Y
T
N
P
R
G
G
N
F
Q
P
G
L
Y
P
S
S
I
N
V
Y
F
G
S
L
T
G
A
T
P
------------
D
G
R
K
S
G
Q
P
---
L
A
D
G
V
S
P
S
R
-
G
-
C
D
V
S
G
P
T
A
A
C
N
S
V
S
K
L
D
H
F
I
A
S
N
G
T
L
F
N
Q
K
F
H
P
S
A
L
K
G
--
D
N
G
L
M
N
L
S
S
L
I
R
S
Y
F
D
-----
Q
-----
K
G
F
H
V
Q
F
N
V
I
D
K
K
I
L
L
A
A
Q
K
N
P
E
---
K
YQD-
L
I
V
R
V
A
G
Y
S
A
Q
F
I
S
L
D
K
S
I
Q
N
D
I
I
A
R
T
E
H
V
M
------------
29
HHSearch
71.17
20%
-60
- C4 -
1R9D
1
?
A:
[37-787]
---------------------------------------------------------------------------------------------------
E
S
F
K
Q
T
--
E
G
Q
P
A
-----
I
---
L
R
--
R
A
L
A
L
---------
K
H
-
I
L
E
N
--------
I
P
I
T
I
R
-
D
Q
E
L
I
V
G
S
L
T
K
E
P
R
S
S
Q
V
F
P
E
F
S
N
K
W
L
Q
D
E
L
D
R
LNKRTG
D
A
----------
F
Q
I
S
E
E
S
K
E
K
L
K
-
D
V
F
E
Y
W
N
G
-
K
T
T
S
E
L
A
T
-
S
Y
M
T
E
E
T
R
E
A
V
-----
N
C
D
V
F
T
V
G
N
Y
Y
Y
N
G
-
V
G
H
V
S
V
D
Y
G
K
V
L
R
V
G
F
N
G
I
I
N
E
A
K
E
Q
L
E
K
N
RSI
D
PDF
I
K
---
K
E
K
F
L
N
S
V
I
I
S
C
------
E
A
A
I
T
Y
V
N
R
Y
A
K
K
A
K
E
I
A
D
N
TSD
A
K
R
K
A
E
L
N
E
I
A
K
I
C
S
K
V
S
G
E
G
A
K
S
F
---------------------------
Y
E
A
C
Q
L
F
W
F
I
H
A
I
I
N
---
I
E
S
N
G
H
S
I
S
P
A
R
F
D
Q
Y
M
Y
P
Y
Y
E
N
D
K
---
N
I
T
D
K
F
A
Q
E
L
I
D
C
I
W
I
K
L
N
D
I
N
K
V
R
D
E
I
S
T
K
H
F
G
G
Y
P
M
Y
Q
N
L
I
V
G
G
Q
N
S
E
G
K
D
A
T
N
K
V
S
Y
M
A
L
E
A
A
V
H
V
-
K
L
P
----
Q
P
S
L
S
V
R
I
W
N
K
T
P
D
-
E
F
L
L
R
A
A
E
L
T
R
E
G--
L
G
L
P
A
Y
Y
N
-----
D
E
V
I
I
P
A
-
L
V
S
R
GLT
L
E
D
A
R
D
Y
--------------
G
I
I
G
C
V
E
P
Q
---
K
P
---
G
K
T
E
G
W
H
D
S
A
F
F
N
L
A
R
I
V
E
L
T
I
N
S
G
F
D
--
K
N
K
Q
I
G
P
K
T
Q
N
F
-
E
E
M
K
S
F
D
E
F
M
K
A
Y
K
A
Q
M
E
Y
F
V
K
H
M
C
C
A
D
N
C
I
D
I
A
H
A
E
R
A
P
L
P
F
L
S
S
M
V
D
----
N
C
I
G
------------
K
G
K
S
LQDGGAE
Y
N
F
S
G
P
Q
G
--
V
---------
G
V
A
N
------
I
G
D
S
L
V
A
V
K
K
I
-----------
V
F
D
E
NKIT
P
S
E
L
K
K
-----
T
L
N
N
D
F
K
N
S
E
E
I
Q
A
L
L
K
N
A
P
K
F
G
N
D
I
D
E
V
D
N
L
A
R
E
G
A
L
V
Y
C
R
E
-
V
N
K
Y
T
N
P
R
G
G
N
F
Q
P
G
L
Y
P
S
S
I
N
V
Y
F
G
S
L
T
G
A
T
P
D
G
---------------
R
K
S
G
Q
P
L
A
D
G
V
S
P
S
R
-
G
C
D
-
V
S
G
P
T
A
A
C
N
S
V
S
K
L
D
H
F
I
A
S
N
G
T
L
F
N
Q
K
F
H
P
S
A
L
K
G
D
--
N
G
L
M
N
L
S
S
L
I
R
S
Y
F
D
-----
Q
-----
K
G
F
H
V
Q
F
N
V
I
D
K
K
I
L
L
A
A
Q
K
N
P
E
---
K
YQD-
L
I
V
R
V
A
G
Y
S
A
Q
F
I
S
L
D
K
S
I
Q
N
D
I
I
A
R
T
E
H
V
M
------------
39
Fugue
70.05
19%
-32
- C4 -
4PKF
4
?
A:
[8-864]
K
V
L
E
Y
KG
K
K
L
N
FTPEDPAEETIPADELHEHLQK
P
S
T
A
R
T
K
R
L
K
E
R
C
R
W
K
H
A
S
A
G
E
F
I
E
K
S
V
T
A
G
I
E
R
M
R
Y
L
T
E
A
H
K
A
S
E
G
K
--
P
E
A
I
R
R
A
L
G
L
-
A
N
V
L
N
K
S
T
L
V
L
--
Q
E
D
E
F
IVGYH
A
---
E
D
--
P
--
N
M
F
P
L
Y
PELS
H
M
A
-
V
Q
D
Y
L
R
SDYSPQ
P
A
D
E
A
A
A
I
N
E
Y
W
K
P
H
S
L
Q
S
K
C
Q
P
Y
F
D
P
A
D
L
G
R
M
Y
Q
V
S
S
M
E
APSFA-
S
G
----------
Y
N
S
-----------
I
V
P
P
Y
-
E
-
T
V
L
E
D
G
L
L
A
R
I
K
L
A
E
K
H
I
A
E
-----
A
Q
A
D
M
-
S
T
F
P
--
W
N
-
G
T
K
G
L
D
N
I
A
K
I
D
N
W
K
A
M
V
I
A
C
K
A
V
I
S
W
--
A
---
R
--------
R
---------
Q
G
------
R
L
C
K
I
-------
V
A
E
N
F
E
T
D
---
P
K
R
Q
A
E
L
L
E
I
A
D
I
C
Q
R
I
P
A
E
P
C
K
G
L
---------------------------
K
D
A
M
Q
A
K
F
F
T
F
L
I
C
H
AIE
R
Y
A
S
G
Y
A
Q
K
E
D
T
L
L
W
P
Y
Y
K
A
S
V
V
D
K
K
F
Q
P
M
S
H
M
D
A
V
E
L
V
E
M
E
R
L
K
I
S
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H
G
A
G
K
S
R
A
Y
R
E
I
F
P
G
S
N
D
L
F
I
L
T
V
G
G
T
N
A
K
G
E
D
A
C
N
D
M
T
D
A
I
L
E
A
A
K
R
I
-
R
T
A
----
E
P
S
I
V
F
R
Y
S
K
K
N
R
E
-
K
T
L
R
W
V
F
E
C
I
R
D
GLG
Y
P
S
I
K
H
D
E
-----
I
G
T
E
Q
M
K
-
E
Y
--------
A
K
F
S
LNGNGAT
D
E
E
A
H
NW
V
N
V
L
C
M
S
P
G
I
H
-
G
R
R
K
T
Q
K
T
R
S
E
-
G
G
G
S
I
F
P
A
K
L
L
E
I
S
L
N
D
G
Y
D
W
S
Y
A
D
M
Q
L
G
P
K
T
G
D
L
S
S
L
K
S
F
E
D
V
W
E
A
F
R
K
Q
Y
Q
Y
A
I
N
L
C
I
S
T
K
D
V
S
R
Y
F
E
Q
R
F
----
L
Q
M
P
F
V
S
----
A
I
D
D
------------
G
C
M
E
----------
L
G
--
M
--
D
ACALSE
Q
P
N
G
W
H
N
P
I
T
T
I
V
A
A
N
S
L
V
A
I
K
K
L
VFEEKKY
T
L
E
Q
L
S
Q
A
---------
L
K
A
N
WE
G
F
E
E
M
R
V
D
-------
F
K
R
A
P
K
W
G
N
D
D
D
Y
A
D
G
I
I
T
R
F
Y
E
E
I
I
G
G
E
M
R
K
I
T
N
Y
S
G
G
P
V
M
P
T
G
Q
A
V
G
L
Y
M
E
V
G
S
R
T
G
P
T
P
--
D
G
R
F
G
G
E
AAD
D
G
G
I
--------
S
P
Y
M
G
T
D
K
-
K
-----
G
P
T
A
V
L
R
S
V
S
K
V
Q
--
K
N
Q
K
G
N
L
L
N
Q
R
L
S
V
P
I
M
R
--
S
K
H
G
F
E
I
W
N
S
Y
I
K
T
W
H
D
-----
L
-----
N
I
D
H
V
Q
F
N
V
V
S
T
D
E
M
R
A
A
Q
R
E
P
E
KHH
D
----
L
I
V
R
V
S
G
Y
S
A
R
F
V
D
I
P
T
Y
G
Q
N
T
I
I
A
R
Q
E
Q
D
F
S
A
S
D
L
E
F
L
N
VEI
28
HHSearch
69.81
20%
-56
- C4 -
2F3O
2
?
A:
[27-775]
-------------------------------------------------------------------------------------------------
Y
T
E
S
M
K
Q
T
--
E
G
E
P
M
-----
I
---
I
R
--
Q
A
K
A
L
---------
K
H
-
V
L
E
N
--------
I
P
I
Q
I
L
-
D
S
E
L
I
V
G
T
M
L
P
N
P
P
G
A
I
I
F
P
E
G
V
G
L
R
I
I
N
E
L
D
S
LPNRET
N
R
----------
L
M
V
D
E
E
D
A
K
V
L
R
E
E
I
A
P
Y
W
Q
R
-
K
T
I
E
A
F
A
F
-
P
L
M
P
D
I
M
Q
I
L
Y
------
T
G
S
V
-
F
V
L
T
E
I
A
G
-
I
S
H
V
A
V
N
Y
P
Y
L
L
R
R
G
F
R
W
F
L
E
E
S
E
R
R
I
R
A
L
---
E
E
S
GVYE
G
E
K
Y
S
F
Y
Q
A
A
K
I
V
S
------
E
A
V
I
N
Y
G
L
R
Y
S
K
L
A
E
E
L
A
E
S
ED-
G
E
R
R
E
E
L
L
K
I
A
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I
C
R
K
V
P
A
E
K
P
E
T
F
---------------------------
W
E
A
V
Q
F
V
W
L
V
Q
S
A
L
H
---
Q
E
N
Y
E
Q
A
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M
G
R
I
D
Q
Y
L
Y
P
F
F
K
K
D
I
G
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G
R
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N
R
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L
A
F
D
I
L
A
N
L
W
I
K
T
N
E
I
V
P
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S
L
L
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Y
F
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G
Q
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N
Q
A
V
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G
C
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Y
G
N
D
A
T
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E
L
T
Y
L
M
L
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V
T
D
R
L
-
R
L
R
----
Q
P
N
V
H
V
R
I
N
K
G
S
P
E
-
S
F
L
K
R
L
A
E
A
I
S
S
G--
C
N
N
L
A
L
F
F
-----
D
D
A
A
V
K
A
-
L
K
N
A
EVD
D
R
D
A
L
N
Y
--------------
T
T
D
G
C
V
E
I
A
---
P
F
---
G
N
S
F
T
S
S
D
A
A
L
I
N
V
A
K
A
L
E
Y
A
L
N
E
G
V
D
L
Q
F
G
Y
E
F
G
A
K
T
----
E
K
P
K
F
L
E
D
L
L
E
K
L
R
E
Q
V
S
H
I
V
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L
V
V
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G
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N
V
L
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Y
A
N
A
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V
K
P
T
P
L
L
S
L
C
V
E
----
D
C
F
E
------------
K
G
V
D
VSRGGAR
Y
N
F
T
G
--
I
Q
A
V
---------
G
I
A
D
------
V
G
D
S
L
V
A
I
E
G
A
-----------
L
N
A
G
YS
M
D
D
I
V
--
E
-----
A
C
R
K
N
F
V
G
Y
E
K
L
H
K
L
L
L
Q
S
P
K
Y
G
N
D
D
D
A
A
D
K
Y
T
K
M
V
L
E
W
Y
C
E
E
-
V
N
R
H
R
N
F
R
G
G
K
F
A
A
G
C
Y
P
M
T
T
N
V
G
F
G
F
F
T
S
A
L
P
S
G
---------------
R
K
S
G
E
P
L
N
P
G
V
S
P
S
T
-
G
M
D
-
R
E
G
V
T
A
V
I
N
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A
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K
L
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N
G
A
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L
T
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N
L
S
S
D
V
L
-
G
E
--
K
G
D
A
V
I
E
A
L
I
K
S
S
M
E
-----
L
-----
G
V
M
H
V
Q
F
N
I
L
K
E
D
L
L
R
K
A
Q
Q
E
P
E
---
K
YRW-
L
L
V
R
V
A
G
W
S
A
Y
F
V
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L
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R
P
V
Q
E
E
V
I
R
R
I
S
C
R
I
------------