@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1777: (2015-12-10 )
MIEITWTVKYITEFIATAFLIILGNGAVANVDLKGTKGNNSGWIIIAIGYGLGVMMPALMFGNVSGNHINPAFTLGLAFSGLFPWAHVGQYILAQILGAMFGQLVVVMVYQPYFVKTENPNHVLGSFSTISALDDGQKSSRKAAYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLVQAGYDQTTAATRISPYVTGSLAVAHLGIGFLVMTLVASLGGPTGPALNPARDLGPRIVHRLLPKQILGQAKEDSKWWYAWVPVLAPIVASILAVALFKLLYL
Atome Classification :
(20 SA)
.........10........20......------..30--------...-....--------------..40-------------.--------........50........60...-.....70........-80........90........100.......110.......120----------..-.....130...--....140.....---..150.......160.......170.......180.......190.......200.......210.......220.......230.......240--.-......250-.......260.......270.......280---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
E
I
T
W
T
V
K
Y
I
T
E
F
I
A
T
A
F
L
I
I
LGNG
A
------
V
A
N
---------
V
D
L
-
K
GTK--------------GNN--------------S--------
G
W
I
I
I
A
IGY
G
L
G
V
M
M
P
A
L
M
FGNV-SGNHIN
P
A
F
T
L
G
L
A
F
-SGLF
P
W
A
H
V
G
Q
Y
I
L
A
Q
I
L
G
A
M
F
G
Q
L
V
V
V
M
V
YQ
P
Y
F
V
KTENPN
H
----------
V
L-GSFS
T
I
S
ALDD--GQKSSR
K
A
A
Y
I
N
---
G
F
L
N
E
F
V
G
S
F
V
L
F
F
G
A
L
A
L
TKNYF
G
V
E
L
V
G
K
L
V
QAGYDQTTAA
T
R
ISPYVT
G
S
L
A
V
A
H
L
G
I
G
F
L
V
M
T
L
V
A
S
LGGPTGPALN
P
A
R
D
L
G
P
R
I
V
H
R
L
L
--
P
-
K
Q
I
LGQAKE-DS
K
W
W
Y
A
W
V
P
V
L
A
P
I
V
A
S
I
L
A
V
A
L
F
K
L
LYL---
23
HHSearch
87.14
33%
-111
- C4 -
1LDF
6
GLPF_ECOLI
A:
[6-255]
----
T
L
K
G
Q
C
I
A
E
F
L
G
T
G
L
L
I
F
F
G
V
G
C
------
V
A
A
---------
L
K
V
-
A
G
A
-----------------
S
--------------
F
--------
G
Q
W
E
I
S
V
I
F
G
L
G
V
A
M
A
I
Y
L
T
A
G
V
-
S
G
A
H
L
N
P
A
V
T
I
A
L
W
L
-
F
A
C
F
D
K
R
K
V
I
P
F
I
V
S
Q
V
A
G
A
F
C
A
A
A
L
V
Y
G
L
Y
Y
N
L
F
F
D
F
E
Q
T
H
H
IVRGSVES
V
D
L
A
-
G
T
F
S
T
Y
P
N
P
H
---
I
-------
N
F
V
Q
---
A
F
A
V
E
M
V
I
T
A
I
L
M
G
L
I
L
A
L
T
D
D
G
N
G
V
P
-------------------------
R
G
P
L
A
P
L
L
I
G
L
L
I
A
V
I
G
A
S
M
G
P
L
T
G
T
A
M
N
P
A
R
D
F
G
P
K
V
F
A
W
L
A
--
G
-
W
G
N
V
A
F
-
T
G
-
G
R
D
I
P
Y
F
L
V
P
L
F
G
P
I
V
G
A
I
V
G
A
F
A
Y
R
K
L
I
G
---
43
Fugue
84.52
30%
-106
- C4 -
1FX8
6
GLPF_ECOLI
A:
[6-259]
----
T
L
K
G
Q
C
I
A
E
F
L
G
T
G
L
L
I
F
F
G
V
G
C
------
V
A
A
---------
L
K
V
A------------------
G
A
S
--------------
F
--------
G
Q
W
E
I
S
V
I
W
G
L
G
V
A
M
A
I
Y
L
T
A
G
V
S-
G
A
H
L
N
P
A
V
T
I
A
L
W
L
F
A
C
-
F
D
K
R
K
V
I
P
F
I
V
S
Q
V
A
G
A
F
C
A
A
A
L
V
Y
G
L
Y
Y
N
L
F
F
D
F
E
Q
T
H
H
----------
I
V
-
R
G
S
V
E
S
V
D
L
A
G
TF
S
T
Y
P
N
P
H
I
N
F
V
Q
---
A
F
A
V
E
M
V
I
T
A
I
L
M
G
L
I
L
A
L
T
D
-------------------------
D
G
N
G
V
P
R
G
P
L
A
P
L
L
I
G
L
L
I
A
V
I
G
A
S
M
G
P
L
T
G
F
A
M
N
P
A
R
D
F
G
P
K
V
F
A
W
L
A
GW
G
-
N
V
A
F
T
---
G
-
G
R
D
I
P
Y
F
L
V
P
L
F
G
P
I
V
G
A
I
V
G
A
F
A
Y
R
K
L
I
G
RHL
2
PsiBlast_PDB
81.52
30%
-95
- C4 -
1LDF
6
GLPF_ECOLI
A:
[10-254]
--------
Q
C
I
A
E
F
L
G
T
G
L
L
I
F
F
G
V
G
C
------
V
A
A
---------
L
K
V
-
A
G
A
S
--------------
F
G
Q
------------------------
W
E
I
S
V
I
-
F
G
L
G
V
A
M
A
I
Y
L
T
A
G
V
-
S
G
A
H
L
N
P
A
V
T
I
A
L
W
L
-
F
A
C
F
D
K
R
K
V
I
P
F
I
V
S
Q
V
A
G
A
F
C
A
A
A
L
V
Y
G
L
Y
Y
N
L
F
F
D
F
E
Q
T
H
H
----------
I
V
R
G
S
V
E
S
V
D
L
--
A
--
G
T
F
S
T
Y
P
N
P
H
I
N
F
V
Q
A
F
A
V
E
M
V
I
T
A
I
L
M
G
L
I
L
A
L
T
D
D
G
N
G
V
P
-----------------------
R
G
P
L
--
A
P
L
L
I
G
L
L
I
A
V
I
G
A
S
M
G
P
L
T
G
T
A
M
N
P
A
R
D
F
G
P
K
V
F
A
W
L
A
--
G
W
G
N
V
A
F
T
G
G
R
-
D
I
P
--
Y
F
L
V
P
L
F
G
P
I
V
G
A
I
V
G
A
F
A
Y
R
K
L
I
G
---
5
PsiBlast_PDB
81.46
30%
-90
- C4 -
1LDI
2
GLPF_ECOLI
A:
[10-254]
--------
Q
C
I
A
E
F
L
G
T
G
L
L
I
F
F
G
V
G
C
------
V
A
A
---------
L
K
V
-
A
G
A
S
--------------
F
G
Q
------------------------
W
E
I
S
V
I
-
W
G
L
G
V
A
M
A
I
Y
L
T
A
G
V
-
S
G
A
H
L
N
P
A
V
T
I
A
L
W
L
-
F
A
C
F
D
K
R
K
V
I
P
F
I
V
S
Q
V
A
G
A
F
C
A
A
A
L
V
Y
G
L
Y
Y
N
L
F
F
D
F
E
Q
T
H
H
----------
I
V
R
G
S
V
E
S
V
D
L
--
A
--
G
T
F
S
T
Y
P
N
P
H
I
N
F
V
Q
A
F
A
V
E
M
V
I
T
A
I
L
M
G
L
I
L
A
L
T
D
D
G
N
G
V
P
-----------------------
R
G
P
L
--
A
P
L
L
I
G
L
L
I
A
V
I
G
A
S
M
G
P
L
T
G
F
A
M
N
P
A
R
D
F
G
P
K
V
F
A
W
L
A
--
G
W
G
N
V
A
F
T
G
G
R
-
D
I
P
--
Y
F
L
V
P
L
F
G
P
I
V
G
A
I
V
G
A
F
A
Y
R
K
L
I
G
---
4
PsiBlast_PDB
81.25
30%
-92
- C4 -
1LDA
2
GLPF_ECOLI
A:
[10-254]
--------
Q
C
I
A
E
F
L
G
T
G
L
L
I
F
F
G
V
G
C
------
V
A
A
---------
L
K
V
-
A
G
A
S
--------------
F
G
Q
------------------------
W
E
I
S
V
I
-
W
G
L
G
V
A
M
A
I
Y
L
T
A
G
V
-
S
G
A
H
L
N
P
A
V
T
I
A
L
W
L
-
F
A
C
F
D
K
R
K
V
I
P
F
I
V
S
Q
V
A
G
A
F
C
A
A
A
L
V
Y
G
L
Y
Y
N
L
F
F
D
F
E
Q
T
H
H
----------
I
V
R
G
S
V
E
S
V
D
L
--
A
--
G
T
F
S
T
Y
P
N
P
H
I
N
F
V
Q
A
F
A
V
E
M
V
I
T
A
I
L
M
G
L
I
L
A
L
T
D
D
G
N
G
V
P
-----------------------
R
G
P
L
--
A
P
L
L
I
G
L
L
I
A
V
I
G
A
S
M
G
P
L
T
G
F
A
M
N
P
A
R
D
F
G
P
K
V
F
A
W
L
A
--
G
W
G
N
V
A
F
T
G
G
R
-
D
I
P
--
Y
F
L
V
P
L
F
G
P
I
V
G
A
I
V
G
A
F
A
Y
R
K
L
I
G
---
3
PsiBlast_PDB
80.68
30%
-92
- C4 -
1FX8
6
GLPF_ECOLI
A:
[10-254]
--------
Q
C
I
A
E
F
L
G
T
G
L
L
I
F
F
G
V
G
C
------
V
A
A
---------
L
K
V
-
A
G
A
S
--------------
F
G
Q
------------------------
W
E
I
S
V
I
-
W
G
L
G
V
A
M
A
I
Y
L
T
A
G
V
-
S
G
A
H
L
N
P
A
V
T
I
A
L
W
L
-
F
A
C
F
D
K
R
K
V
I
P
F
I
V
S
Q
V
A
G
A
F
C
A
A
A
L
V
Y
G
L
Y
Y
N
L
F
F
D
F
E
Q
T
H
H
----------
I
V
R
G
S
V
E
S
V
D
L
--
A
--
G
T
F
S
T
Y
P
N
P
H
I
N
F
V
Q
A
F
A
V
E
M
V
I
T
A
I
L
M
G
L
I
L
A
L
T
D
D
G
N
G
V
P
-----------------------
R
G
P
L
--
A
P
L
L
I
G
L
L
I
A
V
I
G
A
S
M
G
P
L
T
G
F
A
M
N
P
A
R
D
F
G
P
K
V
F
A
W
L
A
--
G
W
G
N
V
A
F
T
G
G
R
-
D
I
P
--
Y
F
L
V
P
L
F
G
P
I
V
G
A
I
V
G
A
F
A
Y
R
K
L
I
G
---
26
HHSearch
80.24
31%
-101
- C4 -
2F2B
1
AQPM_METTM
A:
[2-244]
---
V
S
L
T
K
R
C
I
A
E
F
I
G
T
F
I
L
V
F
F
G
A
G
S
------
A
A
V
---------
T
L
M
-
I
A
S
G
GTSPNPFNIGIGLL
G
G
L
--------------
G
--------
D
W
V
A
I
G
L
A
F
G
F
A
I
A
A
S
I
Y
A
L
G
N
I
-
S
G
C
H
I
N
P
A
V
T
I
G
L
W
S
-
V
K
K
F
P
G
R
E
V
V
P
Y
I
I
A
Q
L
L
G
A
A
F
G
S
F
I
F
L
Q
C
A
G
I
G
A
A
T
V
G
-----------------
G
L
G
A
T
A
P
F
P
G
---
I
-------
S
Y
W
Q
---
A
M
L
A
E
V
V
G
T
F
L
L
M
I
T
I
M
G
I
A
V
D
E
R
A
---------------------------
P
K
G
F
A
G
I
I
I
G
L
T
V
A
G
I
I
T
T
L
G
N
I
S
G
S
S
L
N
P
A
R
T
F
G
P
Y
L
N
D
M
I
F
--
A
--
G
--------
T
D
L
W
N
Y
Y
S
I
Y
V
I
G
P
I
V
G
A
V
L
A
A
L
T
Y
Q
Y
L
T
S
---
24
HHSearch
79.89
27%
-112
- C4 -
2ZZ9
5
AQP4_RAT
A:
[8-230]
-
W
T
Q
A
F
W
K
A
V
T
A
E
F
L
A
M
L
I
F
V
L
L
S
V
G
S
------
T
I
N
---------
W
G
G
-
S
-
N
---------------
P
L
P
--------------
V
--------
D
M
V
L
I
S
L
C
F
G
L
S
I
A
T
M
V
Q
C
F
G
H
I
-
S
G
G
H
I
N
P
A
V
T
V
A
M
V
C
-
T
R
K
I
S
I
A
K
S
V
F
Y
I
T
A
Q
C
L
G
A
I
I
G
A
G
I
L
Y
L
V
T
P
P
S
V
V
G
-------------------
G
L
G
V
T
T
V
H
G
N
---
L
-------
T
A
G
H
---
G
L
L
V
E
L
I
I
T
F
Q
L
V
F
T
I
F
A
S
C
D
D
K
R
T
D
--------------------------
V
T
G
S
V
A
L
A
I
G
F
S
V
A
I
G
H
L
F
A
I
N
Y
T
G
A
S
M
N
P
A
R
S
F
G
P
A
V
I
M
G
------------------
N
W
E
N
H
W
I
Y
W
V
G
P
I
I
G
A
V
L
A
G
A
L
Y
E
Y
V
F
C
---
9
PsiBlast_PDB
79.56
25%
-120
- C4 -
2ZZ9
5
AQP4_RAT
A:
[19-231]
------------
E
F
L
A
M
L
I
F
V
L
L
S
V
G
S
------
T
I
N
WGGSNPLP-
V
D
M
-----------------------------------------------
V
L
I
S
L
C
F
G
L
S
I
A
T
M
V
Q
C
F
G
H
I
-
S
G
G
H
I
N
P
A
V
T
V
A
M
V
C
-
T
R
K
I
S
I
A
K
S
V
F
Y
I
T
A
Q
C
L
G
A
I
I
G
A
G
I
L
Y
L
V
T
P
P
S
V
V
G
G
L
G
V
T
T
----------
V
H
-
G
N
L
T
A
------------------
G
H
---
G
L
L
V
E
L
I
I
T
F
Q
L
V
F
T
I
F
A
S
C
D
----------------
D
K
R
T
D
-------
V
T
G
S
V
A
L
A
---
I
G
F
S
V
A
I
G
H
L
F
A
I
N
Y
T
G
A
S
M
N
P
A
R
S
F
G
P
A
V
-----------
I
M
G
N
-------
W
E
N
H
W
I
Y
W
V
G
P
I
I
G
A
V
L
A
G
A
L
Y
E
Y
V
F
C
---
6
PsiBlast_PDB
78.40
25%
-107
- C4 -
2EVU
8
AQPM_METTM
A:
[2-243]
---
V
S
L
T
K
R
C
I
A
E
F
I
G
T
F
I
L
V
F
F
G
A
G
S
------
A
A
V
---------
T
L
M
-
I
A
S
G
--------------
G
T
S
PNPFNIGIGLLGGL
G
--------
D
W
V
A
I
G
L
A
F
G
F
A
I
A
A
S
I
Y
A
L
G
N
I
-
S
G
C
H
I
N
P
A
V
T
I
G
L
W
S
-
V
K
K
F
P
G
R
E
V
V
P
Y
I
I
A
Q
L
L
G
A
A
F
G
S
F
I
--------
F
L
Q
C
A
G
--------------
I
-
G
A
-
A
T
V
G
G
L
-
G
--
A
T
A
P
F
P
G
I
S
Y
W
Q
---
A
M
L
A
E
V
V
G
T
F
L
L
M
I
T
I
M
G
I
A
--------
V
D
E
R
A
P
K
G
F
-------------------
A
G
I
I
I
G
L
T
V
A
G
I
I
T
T
L
G
N
I
S
G
S
S
L
N
P
A
R
T
F
G
P
Y
L
N
D
M
I
F
--
A
-
G
T
D
L
---------
W
N
Y
Y
S
I
Y
V
I
G
P
I
V
G
A
V
L
A
A
L
T
Y
Q
Y
L
T
S
---
7
PsiBlast_PDB
77.80
25%
-107
- C4 -
2F2B
1
AQPM_METTM
A:
[2-243]
---
V
S
L
T
K
R
C
I
A
E
F
I
G
T
F
I
L
V
F
F
G
A
G
S
------
A
A
V
---------
T
L
M
-
I
A
S
G
--------------
G
T
S
PNPFNIGIGLLGGL
G
--------
D
W
V
A
I
G
L
A
F
G
F
A
I
A
A
S
I
Y
A
L
G
N
I
-
S
G
C
H
I
N
P
A
V
T
I
G
L
W
S
-
V
K
K
F
P
G
R
E
V
V
P
Y
I
I
A
Q
L
L
G
A
A
F
G
S
F
I
--------
F
L
Q
C
A
G
--------------
I
-
G
A
-
A
T
V
G
G
L
-
G
--
A
T
A
P
F
P
G
I
S
Y
W
Q
---
A
M
L
A
E
V
V
G
T
F
L
L
M
I
T
I
M
G
I
A
--------
V
D
E
R
A
P
K
G
F
-------------------
A
G
I
I
I
G
L
T
V
A
G
I
I
T
T
L
G
N
I
S
G
S
S
L
N
P
A
R
T
F
G
P
Y
L
N
D
M
I
F
--
A
-
G
T
D
L
---------
W
N
Y
Y
S
I
Y
V
I
G
P
I
V
G
A
V
L
A
A
L
T
Y
Q
Y
L
T
S
---
8
PsiBlast_PDB
77.20
25%
-103
- C4 -
3NE2
3
AQPM_ARCFU
A:
[2-243]
--
T
M
T
L
A
K
R
F
T
A
E
V
V
G
T
F
I
L
V
F
F
G
P
G
A
A
V
I
T
L
M
I
A
N
---------
G
A
D
-
K
P
N
E
--------------
F
N
I
--------------
G
IGALGGL
G
D
W
F
A
I
G
M
A
F
A
L
A
I
A
A
V
I
Y
S
L
G
R
I
-
S
G
A
H
I
N
P
A
V
T
I
A
L
W
S
-
I
G
R
F
P
G
R
E
V
V
P
Y
I
V
A
Q
F
I
G
A
A
L
G
S
L
L
F
L
A
C
V
G
P
A
A
A
T
V
G
G
--------------
L
-
G
A
T
A
P
F
P
G
I
G
Y
--
G
Q
A
-------------
I
L
T
E
A
I
G
T
F
L
L
M
L
----------------
V
I
M
G
V
A
V
D
E
-----
R
A
P
P
------
G
F
A
G
L
V
I
G
L
T
V
G
G
I
I
T
T
I
G
N
I
T
G
S
S
L
N
P
A
R
T
F
G
P
Y
L
G
D
S
L
M
--
G
-
I
N
L
----------
W
Q
Y
F
P
I
Y
V
I
G
P
I
V
G
A
V
A
A
A
W
L
Y
N
Y
L
A
K
---
31
HHSearch
76.33
27%
-106
- C4 -
3GD8
6
AQP4_HUMAN
A:
[2-221]
----
A
F
W
K
A
V
T
A
E
F
L
A
M
L
I
F
V
L
L
S
L
G
S
------
T
I
N
---------
W
G
G
-
T
E
K
P
---------------
L
P
--------------
V
--------
D
M
V
L
I
S
L
C
F
G
L
S
I
A
T
M
V
Q
C
F
G
H
I
-
S
G
G
H
I
N
P
A
V
T
V
A
M
V
C
-
T
R
K
I
S
I
A
K
S
V
F
Y
I
A
A
Q
C
L
G
A
I
I
G
A
G
I
L
Y
L
V
T
P
P
S
V
V
G
G
L
-------------------
G
V
T
M
V
H
G
N
---
L
-------
T
A
G
H
---
G
L
L
V
E
L
I
I
T
F
Q
L
V
F
T
I
F
A
S
C
D
S
K
R
T
D
--------------------------
V
T
G
S
I
A
L
A
I
G
F
S
V
A
I
G
H
L
F
A
I
N
Y
T
G
A
S
M
N
P
A
R
S
F
G
P
A
V
I
M
G
------------------
N
W
E
N
H
W
I
Y
W
V
G
P
I
I
G
A
V
L
A
G
G
L
Y
E
Y
V
F
C
---
27
HHSearch
76.25
27%
-101
- C4 -
3C02
6
?
A:
[8-242]
----
S
Y
V
R
E
F
I
G
E
F
L
G
T
F
V
L
M
F
L
G
E
G
A
------
T
A
N
---------
F
H
T
-
T
G
L
-----------------
S
--------------
G
--------
D
W
Y
K
L
C
L
G
W
G
L
A
V
F
F
G
I
L
V
S
A
K
L
-
S
G
A
H
L
N
L
A
V
S
I
G
L
S
S
-
I
N
K
F
D
L
K
K
I
P
V
Y
F
F
A
Q
L
L
G
A
F
V
G
T
S
T
V
Y
G
L
Y
H
G
F
I
S
N
S
K
I
P
-------------
Q
-
F
A
W
E
T
S
R
N
P
S
---
I
-------
S
L
T
G
---
A
F
F
N
E
L
I
L
T
G
I
L
L
L
V
I
L
V
V
V
D
E
N
I
C
G
K
------------------------
F
H
I
L
K
L
S
S
V
V
G
L
I
I
L
C
I
G
I
T
F
G
G
N
T
G
F
A
L
N
P
S
R
D
L
G
S
R
F
L
S
L
I
---
A
-
Y
G
K
----
D
T
F
T
K
D
N
F
Y
F
W
V
P
L
V
A
P
C
V
G
S
V
V
F
C
Q
F
Y
D
K
V
I
C
---
29
HHSearch
76.14
24%
-97
- C4 -
3CN5
-
?
A:
[34-264]
--
L
W
S
F
W
R
A
A
I
A
E
F
I
A
T
L
L
F
L
Y
I
T
V
A
T
------
V
I
G
---------
H
S
K
-
E
T
V
V
--------------
C
G
S
--------------
V
--------
G
L
L
G
I
A
W
A
F
G
G
M
I
F
V
L
V
Y
C
T
A
G
I
-
S
G
G
H
I
N
P
A
V
T
F
G
L
F
L
-
A
R
K
V
E
L
L
R
A
L
V
Y
M
I
A
Q
C
L
G
A
I
C
G
V
G
L
V
K
A
F
M
K
G
P
Y
N
Q
F
G
G
G
------------------
A
N
S
V
A
L
G
---
Y
-------
N
K
G
T
---
A
L
G
A
E
I
I
G
T
F
V
L
V
Y
T
V
F
S
A
T
D
P
K
R
S
A
R
D
----------------------
S
H
V
P
I
L
A
P
L
P
I
G
F
A
V
F
M
V
H
L
A
T
I
P
I
T
G
T
G
I
N
P
A
R
S
F
G
A
A
V
I
F
N
S
---------------
N
K
V
W
D
D
Q
W
I
F
W
V
G
P
F
I
G
A
A
V
A
A
A
Y
H
Q
Y
V
L
R
---
11
PsiBlast_PDB
75.87
25%
-116
- C4 -
2D57
-
AQP4_RAT
A:
[41-253]
------------
E
F
L
A
M
L
I
F
V
L
L
S
V
G
S
------
T
I
N
W
GGSENPLP
V
D
M
-----------------------------------------------
V
L
I
S
L
C
F
G
L
S
I
A
T
M
V
Q
C
F
G
H
I
-
S
G
G
H
I
N
P
A
V
T
V
A
M
V
C
-
T
R
K
I
S
I
A
K
S
V
F
Y
I
T
A
Q
C
L
G
A
I
I
G
A
G
I
L
Y
L
V
T
P
P
S
V
V
G
G
L
G
V
T
T
----------
V
H
-
G
N
L
T
A
------------------
G
H
---
G
L
L
V
E
L
I
I
T
F
Q
L
V
F
T
I
F
A
---------------------
S
C
D
S
K
R
T
D
--
V
T
G
S
V
A
L
A
---
I
G
F
S
V
A
I
G
H
L
F
A
I
N
Y
T
G
A
S
M
N
P
A
R
S
F
G
P
A
V
-----------
I
M
G
N
-------
W
E
N
H
W
I
Y
W
V
G
P
I
I
G
A
V
L
A
G
A
L
Y
E
Y
V
F
C
---
10
PsiBlast_PDB
74.14
25%
-151
- C- -
3IYZ
-
AQP4_RAT
A:
[41-253]
------------
E
F
L
A
M
L
I
F
V
L
L
S
V
G
S
------
T
I
N
WGGSNPLP-
V
D
M
-----------------------------------------------
V
L
I
S
L
C
F
G
L
S
I
A
T
M
V
Q
C
F
G
H
I
-
S
G
G
H
I
N
P
A
V
T
V
A
M
V
C
-
T
R
K
I
S
I
A
K
S
V
F
Y
I
T
A
Q
C
L
G
A
I
I
G
A
G
I
L
Y
L
V
T
P
P
S
V
V
G
G
L
G
V
T
T
----------
V
H
-
G
N
L
T
A
------------------
G
H
---
G
L
L
V
E
L
I
I
T
F
Q
L
V
F
T
I
F
A
S
C
D
----------------
D
K
R
T
D
-------
V
T
G
S
V
A
L
A
---
I
G
F
S
V
A
I
G
H
L
F
A
I
N
Y
T
G
A
S
M
N
P
A
R
S
F
G
P
A
V
-----------
I
M
G
N
-------
W
E
N
H
W
I
Y
W
V
G
P
I
I
G
A
V
L
A
G
A
L
Y
E
Y
V
F
C
---
25
HHSearch
73.85
27%
-141
- C- -
3IYZ
-
AQP4_RAT
A:
[31-252]
--
T
Q
A
F
W
K
A
V
T
A
E
F
L
A
M
L
I
F
V
L
L
S
V
G
S
------
T
I
N
---------
W
G
G
-
S
-
N
---------------
P
L
P
--------------
V
--------
D
M
V
L
I
S
L
C
F
G
L
S
I
A
T
M
V
Q
C
F
G
H
I
-
S
G
G
H
I
N
P
A
V
T
V
A
M
V
C
-
T
R
K
I
S
I
A
K
S
V
F
Y
I
T
A
Q
C
L
G
A
I
I
G
A
G
I
L
Y
L
V
T
P
P
S
V
V
G
-------------------
G
L
G
V
T
T
V
H
G
N
---
L
-------
T
A
G
H
---
G
L
L
V
E
L
I
I
T
F
Q
L
V
F
T
I
F
A
S
C
D
D
K
R
T
D
--------------------------
V
T
G
S
V
A
L
A
I
G
F
S
V
A
I
G
H
L
F
A
I
N
Y
T
G
A
S
M
N
P
A
R
S
F
G
P
A
V
I
M
G
------------------
N
W
E
N
H
W
I
Y
W
V
G
P
I
I
G
A
V
L
A
G
A
L
Y
E
Y
V
F
C
---
33
HHSearch
73.30
26%
-114
* C4 *
3D9S
1
AQP5_HUMAN
A:
[8-226]
--
S
V
A
F
L
K
A
V
F
A
E
F
L
A
T
L
I
F
V
F
F
G
L
G
S
------
A
L
K
---------
W
P
S
--------------------
A
L
--------------
P
--------
T
I
L
Q
I
A
L
A
F
G
L
A
I
G
T
L
A
Q
A
L
G
P
V
-
S
G
G
H
I
N
P
A
I
T
L
A
L
L
V
-
G
N
Q
I
S
L
L
R
A
F
F
Y
V
A
A
Q
L
V
G
A
I
A
G
A
G
I
L
Y
G
V
A
P
L
N
A
R
G
N
-------------------
L
A
V
N
A
L
N
N
N
---
T
-------
T
Q
G
Q
---
A
M
V
V
E
L
I
L
T
F
Q
L
A
L
C
I
F
A
S
T
D
S
R
R
T
S
--------------------------
P
V
G
S
P
A
L
S
I
G
L
S
V
T
L
G
H
L
V
G
I
Y
F
T
G
C
S
M
N
P
A
R
S
F
G
P
A
V
V
M
N
R
F
-----------------
S
P
A
H
W
V
F
W
V
G
P
I
V
G
A
V
L
A
A
I
L
Y
F
Y
L
L
F
---
30
HHSearch
73.01
23%
-103
- C4 -
3LLQ
-
AQPZ2_AGRFC
A:
[1-225]
-----
M
G
R
K
L
L
A
E
F
F
G
T
F
W
L
V
F
G
G
C
G
S
------
A
V
F
---------
A
A
A
-
F
P
E
----------------
L
G
--------------
I
--------
G
F
T
G
V
A
L
A
F
G
L
T
V
L
T
M
A
Y
A
V
G
G
I
-
S
G
G
H
F
N
P
A
V
S
V
G
L
T
V
-
A
G
R
F
P
A
S
S
L
V
P
Y
V
I
A
Q
V
A
G
A
I
V
A
A
A
A
L
Y
V
I
A
T
G
K
A
G
I
D
L
G
G
F
-----------
A
S
-
N
G
Y
G
E
H
S
P
G
G
---
Y
-------
S
L
V
S
---
A
L
L
I
E
I
I
L
T
A
F
F
L
I
V
I
L
G
S
T
H
G
R
V
----------------------------
P
A
G
F
A
P
I
A
I
G
L
A
L
T
L
I
H
L
I
S
I
P
V
T
N
T
S
V
N
P
A
R
S
T
G
Q
A
L
F
V
G
G
-----
W
-----------
A
L
Q
Q
L
W
L
F
W
L
A
P
I
V
G
G
A
A
G
A
V
I
W
K
L
F
G
E
---