@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1841: (2015-12-11 )
MPNVKDITRESWILSTFPEWGTWLNEEIEEEVVADGNFAMWWLGNCGVWIKTPGGANVVMDLWSNRGKSTKKVKDMVRGHQMANMAGVRKLQPNLRAQPMVIDPFAINELDYYLVSHFHSDHIDINTAAAIINNPNLDHVKFVGPYECGEIWKKWGVPEERIIVIKPGESFEFKDIKVTAVESFDRTCLVTLPVDGAEEHDGELAGLAVTDEEMARKAVNYIFETPGGTIYHGADSHFSNYFAKHGKDYKIDVAINNYGDNPVGIQDKMTSIDLLRMAENLRAKVIIPVHYDIWSNFMASTDEILQLWKMRKERLQYDFHPFIWEVGGKYTYPQDKDRIEYHHPRGFDDCFEQESNIQFKALL
Atome Classification :
(20 SA)
.........10........20........-30.........40..------..-----------....50........60........70........80........90......--..100.....-..110.......120------.......130...--------....140.......-150...-.---------------..----------.160.......-170.-......180.......190.......200....-...210.......220...--....230.......240--.--...---...250.....-..260---.---......-270.......280-.........290.......300.......310.......320.......330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
N
V
K
D
I
T
RES
W
I
L
STFP
E
W
G
T
W
L
N
E
E
I
E
-
E
-
E
V
VADG
N
F
A
M
W
W
L------GN-----------C
G
V
W
I
KTPGG
A
N
V
V
M
D
L
W
SNRGK
S
T
K
K
V
K
D
M
V
R
G
H
Q
M
A
N
M
A
G
V
R
KLQPNLRA--Q
P
M
V
IDPFAI-
N
E
L
D
Y
Y
L
V
S
H
FHSDH------IDINT
A
A
A
IINNP--------NL
D
H
V
K
F
VG
P
Y
E
C
G
-
E
I
W
K
KW-G---------------VP----------EE
R
I
I
V
I
KPGE-SF
E
F
-
K
D
I
K
V
T
A
VESFD
R
T
C
L
V
T
LPVDGAEEHDGELAG-
L
A
V
T
D
E
E
M
A
R
K
A
V
N
Y
I
F
ET--PGG
T
I
YHGA
D
S
H
F
S
N
Y
F
--
A
--KHG---K
D
Y
K
I
D
V
A
INN-YGDNP---V---G
I
Q
D
K
M
-
T
S
I
D
L
L
R
M
A
E
N---L
R
A
K
V
I
I
P
V
H
Y
D
I
W
S
N
F
MA
S
T
D
E
I
L
Q
L
W
K
M
R
K
E
R
LQYDFHP
F
I
W
EVGGKYTYPQDKD
R
I
E
YHHPRG
F
D
D
C
F
EQESN
I
Q
F
K
ALL
13
PsiBlast_CBE
96.56
54%
-102
- C5 -
3BV6
2
?
B:
[26-379]
-
S
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
-
K
G
V
S
S
Y
D
K
A
I
L
-------
D
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
3
PsiBlast_PDB
95.80
54%
-102
- C5 -
3BV6
2
?
A:
[27-379]
--
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
-
K
G
V
S
S
Y
D
K
A
I
L
-------
D
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
11
PsiBlast_CBE
95.78
54%
-100
- C5 -
3BV6
2
?
D:
[26-379]
-
S
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
-
K
G
V
S
S
Y
D
K
A
I
L
-------
D
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
9
PsiBlast_CBE
95.75
54%
-102
- C5 -
3BV6
2
?
F:
[26-379]
-
S
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
-
K
G
V
S
S
Y
D
K
A
I
L
-------
D
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
12
PsiBlast_CBE
95.74
54%
-102
- C5 -
3BV6
2
?
C:
[27-379]
--
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
-
K
G
V
S
S
Y
D
K
A
I
L
-------
D
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
10
PsiBlast_CBE
95.55
54%
-100
- C5 -
3BV6
2
?
E:
[26-379]
-
S
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
-
K
G
V
S
S
Y
D
K
A
I
L
-------
D
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
34
Fugue
95.21
55%
-101
- C5 -
3BV6
2
?
A:
[27-379]
--
K
V
N
E
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
T
W
L
N
E
E
I
E
-
Q
-
T
V
V
E
P
N
T
F
S
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
A
G
N
T
N
L
S
I
D
F
W
C
G
T
G
K
K
T
Q
K
N
R
L
M
N
T
Q
H
Q
M
M
R
M
G
G
V
E
A
L
Q
P
N
L
R
T
--
S
I
F
P
L
D
P
F
A
I
-
K
E
I
D
A
V
L
A
S
H
D
H
A
D
H
------
I
D
V
N
V
A
A
A
V
L
Q
N
C
--------
G
-
E
H
V
K
F
I
G
P
Q
A
C
V
-
D
L
W
L
G
W
-
G
---------------
V
P
----------
Q
E
R
C
I
V
A
K
V
G
D
-
V
L
E
I
-
G
D
V
K
I
R
V
L
D
S
F
D
R
T
A
L
V
T
L
P
K
G
V
S
S
Y
D
K
A
I
L
D
--------
G
M
D
E
R
A
V
N
Y
L
I
E
T
--
S
G
G
S
V
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
D
Y
Q
I
D
V
A
L
L
S
-
Y
G
E
N
P
---
R
---
G
V
T
D
K
M
-
T
S
S
D
V
L
R
A
A
E
S
---
L
D
C
Q
V
V
V
P
F
H
H
D
I
W
A
N
F
Q
N
D
P
R
E
I
E
V
L
W
N
M
K
K
D
R
L
Q
Y
Q
F
A
P
F
F
W
Q
V
G
G
K
Y
T
Y
P
T
D
K
G
R
M
H
Y
Q
H
F
R
G
F
Q
D
I
F
K
N
E
P
E
L
P
Y
K
A
F
L
1
PsiBlast_PDB
94.82
57%
-106
- C5 -
2WYM
4
ULAG_ECOLI
A:
[1-340]
M
S
K
V
K
S
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
S
W
L
N
E
E
I
E
-
Q
-
E
Q
V
A
P
G
T
F
A
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
E
G
G
T
N
V
C
V
D
F
W
C
G
T
G
K
Q
S
H
G
-----------------
K
L
Q
P
N
L
R
T
--
T
P
F
V
L
D
P
F
A
I
-
R
Q
I
D
A
V
L
A
T
H
D
H
N
D
H
------
I
D
V
N
V
A
A
A
V
M
Q
N
---------
C
A
D
D
V
P
F
I
G
P
K
T
C
V
-
D
L
W
I
G
W
-
G
---------------
V
P
----------
K
E
R
C
I
V
V
K
P
G
D
-
V
V
K
V
-
K
D
I
E
I
H
A
L
D
A
F
D
-----------------------------
M
D
D
R
A
V
N
Y
L
F
K
T
--
P
G
G
S
L
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
E
H
Q
I
D
V
A
L
G
S
-
Y
G
E
N
P
---
R
---
G
I
T
D
K
M
-
T
S
A
D
M
L
R
M
G
E
A
---
L
N
A
K
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
P
Q
E
I
R
V
L
W
E
M
K
K
D
R
L
K
Y
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
K
D
N
F
E
Y
H
Y
P
R
G
F
D
D
--------------
14
HHSearch
94.79
59%
-105
- C5 -
2WYL
5
ULAG_ECOLI
A:
[1-338]
M
S
K
V
K
S
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
S
W
L
N
E
E
I
E
-
Q
-
E
Q
V
A
P
G
T
F
A
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
E
G
G
T
N
V
C
V
D
F
W
C
G
T
G
K
Q
S
H
G
N
----------------
K
L
Q
P
N
L
R
T
--
T
P
F
V
L
D
P
F
A
I
-
R
Q
I
D
A
V
L
A
T
H
D
H
N
D
H
------
I
D
V
N
V
A
A
A
V
M
Q
N
C
---------
A
D
D
V
P
F
I
G
P
K
T
C
V
-
D
L
W
I
G
W
-
G
---------------
V
P
----------
K
E
R
C
I
V
V
K
P
G
D
-
V
V
K
V
-
K
D
I
E
I
H
A
L
D
A
F
D
R
---------------------------
G
M
D
D
R
A
V
N
Y
L
F
K
T
--
P
G
G
S
L
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
E
H
Q
I
D
V
A
L
G
S
-
Y
G
E
N
P
---
R
---
G
I
T
D
K
M
-
T
S
A
D
M
L
R
M
G
E
A
---
L
N
A
K
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
P
Q
E
I
R
V
L
W
E
M
K
K
D
R
L
K
Y
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
K
D
N
F
E
Y
H
Y
P
R
G
F
----------------
7
PsiBlast_CBE
94.34
57%
-103
- C5 -
2WYM
3
ULAG_ECOLI
B:
[1-337]
M
S
K
V
K
S
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
S
W
L
N
E
E
I
E
-
Q
-
E
Q
V
A
P
G
T
F
A
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
E
G
G
T
N
V
C
V
D
F
W
C
G
T
G
K
Q
S
H
G
------------------
L
Q
P
N
L
R
T
--
T
P
F
V
L
D
P
F
A
I
-
R
Q
I
D
A
V
L
A
T
H
D
H
N
D
H
------
I
D
V
N
V
A
A
A
V
M
Q
N
---------
C
A
D
D
V
P
F
I
G
P
K
T
C
V
-
D
L
W
I
G
W
-
G
---------------
V
P
----------
K
E
R
C
I
V
V
K
P
G
D
-
V
V
K
V
-
K
D
I
E
I
H
A
L
D
A
F
D
----------------------------
G
M
D
D
R
A
V
N
Y
L
F
K
T
--
P
G
G
S
L
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
E
H
Q
I
D
V
A
L
G
S
-
Y
G
E
N
P
---
R
---
G
I
T
D
K
M
-
T
S
A
D
M
L
R
M
G
E
A
---
L
N
A
K
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
P
Q
E
I
R
V
L
W
E
M
K
K
D
R
L
K
Y
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
K
D
N
F
E
Y
H
Y
P
R
G
-----------------
6
PsiBlast_CBE
94.06
57%
-103
- C5 -
2WYM
2
ULAG_ECOLI
E:
[1-338]
M
S
K
V
K
S
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
S
W
L
N
E
E
I
E
-
Q
-
E
Q
V
A
P
G
T
F
A
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
E
G
G
T
N
V
C
V
D
F
W
C
G
T
G
K
Q
S
H
G
------------------
L
Q
P
N
L
R
T
--
T
P
F
V
L
D
P
F
A
I
-
R
Q
I
D
A
V
L
A
T
H
D
H
N
D
H
------
I
D
V
N
V
A
A
A
V
M
Q
N
---------
C
A
D
D
V
P
F
I
G
P
K
T
C
V
-
D
L
W
I
G
W
-
G
---------------
V
P
----------
K
E
R
C
I
V
V
K
P
G
D
-
V
V
K
V
-
K
D
I
E
I
H
A
L
D
A
F
D
-----------------------------
M
D
D
R
A
V
N
Y
L
F
K
T
--
P
G
G
S
L
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
E
H
Q
I
D
V
A
L
G
S
-
Y
G
E
N
P
---
R
---
G
I
T
D
K
M
-
T
S
A
D
M
L
R
M
G
E
A
---
L
N
A
K
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
P
Q
E
I
R
V
L
W
E
M
K
K
D
R
L
K
Y
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
K
D
N
F
E
Y
H
Y
P
R
G
F
----------------
2
PsiBlast_PDB
92.42
55%
-105
- C5 -
2WYL
5
ULAG_ECOLI
A:
[4-338]
---
V
K
S
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
S
W
L
N
E
E
I
E
-
Q
-
E
Q
V
A
P
G
T
F
A
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
E
G
G
T
N
V
C
V
D
F
W
C
G
T
G
K
Q
S
H
G
N
----------------
K
L
Q
P
N
L
R
T
--
T
P
F
V
L
D
P
F
A
I
-
R
Q
I
D
A
V
L
A
T
H
D
H
N
D
H
------
I
D
V
N
V
A
A
A
V
M
Q
N
---------
C
A
D
D
V
P
F
I
G
P
K
T
C
V
-
D
L
W
I
G
W
-
G
---------------
V
P
----------
K
E
R
C
I
V
V
K
P
G
D
-
V
V
K
V
-
K
D
I
E
I
H
A
L
D
A
F
D
R
---------------------------
G
M
D
D
R
A
V
N
Y
L
F
K
T
--
P
G
G
S
L
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
E
H
Q
I
D
V
A
L
G
S
-
Y
G
E
N
P
---
R
---
G
I
T
D
K
M
-
T
S
A
D
M
L
R
M
G
E
A
---
L
N
A
K
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
P
Q
E
I
R
V
L
W
E
M
K
K
D
R
L
K
Y
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
K
D
N
F
E
Y
H
Y
P
R
G
F
----------------
8
PsiBlast_CBE
69.25
57%
-21
- C5 -
2WYM
2
ULAG_ECOLI
F:
[6-338]
---
V
K
S
I
T
R
E
S
W
I
L
S
T
F
P
E
W
G
S
W
L
N
E
E
I
E
-
Q
-
E
Q
V
A
P
G
T
F
A
M
W
W
L
------
G
C
-----------
T
G
I
W
L
K
S
E
G
G
T
N
V
C
V
D
F
W
C
G
T
G
K
Q
S
H
G
-----------------
K
L
Q
P
N
L
R
T
--
T
P
F
V
L
D
P
F
A
I
-
R
Q
I
D
A
V
L
A
T
H
D
H
N
D
H
------
I
D
V
N
V
A
A
A
V
M
Q
N
---------
C
A
D
D
V
P
F
I
G
P
K
T
C
V
-
D
L
W
I
G
W
-
G
---------------
V
P
----------
K
E
R
C
I
V
V
K
P
G
D
-
V
V
K
V
-
K
D
I
E
I
H
A
L
D
A
F
D
R
-----------------------------
D
D
R
A
V
N
Y
L
F
K
T
--
P
G
G
S
L
Y
H
S
G
D
S
H
Y
S
N
Y
Y
--
A
--
K
H
G
---
N
E
H
Q
I
D
V
A
L
G
S
-
Y
G
E
N
P
---
R
---
G
I
T
D
K
M
-
T
S
A
D
M
L
R
M
G
E
A
---
L
N
A
K
V
V
I
P
F
H
H
D
I
W
S
N
F
Q
A
D
P
Q
E
I
R
V
L
W
E
M
K
K
D
R
L
K
Y
G
F
K
P
F
I
W
Q
V
G
G
K
F
T
W
P
L
D
K
D
N
F
E
Y
H
Y
P
R
G
F
----------------
15
HHSearch
59.79
18%
-92
- C5 -
3RPC
2
?
A:
[3-264]
-------------------------------------
A
M
T
Q
Y
T
H
I
------
R
N
-----------
A
T
G
K
L
T
I
K
-
N
T
T
F
L
I
D
P
F
L
A
P
K
D
T
Y
P
G
F
E
---------
G
T
F
N
Y
Q
-----
Q
R
M
PM
V
D
L
P
L
S
M
D
D
L
L
S
N
V
T
A
V
V
V
T
H
T
H
L
D
H
------
W
D
--
D
T
A
I
N
S
I
P
-----------
K
S
L
P
I
F
V
Q
N
T
A
D
K
E
L
I
T
S
Q
-
G
---------------
F
------------
I
D
--
V
R
I
I
F
E
-
S
L
E
F
-
N
G
I
T
L
R
K
T
G
G
S
H
G
T
V
E
M
Y
A
N
------------
P
-
V
L
---
A
P
L
A
G
D
A
M
G
V
I
F
E
A
A
-
D
E
P
T
V
Y
L
V
G
D
T
V
W
T
S
D
V
--
E
--
K
A
L
---
L
R
F
D
P
N
V
I
I
M
N
-
T
G
Y
A
Q
---
I
LGF
E
D
S
I
I
M
-
G
T
K
D
I
G
R
M
V
V
R
---
K
P
E
A
K
I
I
A
V
H
M
D
T
V
N
H
T
A
T
S
R
K
D
V
R
K
F
I
K
G
N
N
----
I
E
S
H
V
A
V
P
E
D
G
E
T
I
T
L
-------------------------------
16
HHSearch
58.45
16%
-92
* C5 *
1ZKP
3
?
A:
[20-267]
----------------------------------
F
Q
S
N
A
M
K
M
T
V
V
------
G
F
W
G
GFPEAG
E
A
T
S
G
Y
L
F
E
H
D
-
G
F
R
L
L
V
D
C
G
S
G
V
L
A
---------------------------
Q
L
--
Q
K
-
Y
I
---
T
P
-
S
D
I
D
A
V
V
L
S
H
Y
H
H
D
H
------
V
--
A
D
I
G
V
L
Q
Y
A
R
L
I
T
S
A
T
KG
Q
L
P
E
L
P
I
Y
G
H
T
F
D
E
-
N
G
F
H
S
L
T
H
---------------
E
P
----------
H
T
K
G
I
P
Y
N
P
E
E
-
T
L
Q
I
-
G
P
F
S
I
S
F
L
K
T
V
H
P
------------------------------
V
T
C
F
A
M
R
I
T
A
--
G
N
D
I
V
V
Y
S
A
D
S
S
Y
I
P
E
F
--
I
--
P
F
T
---
K
--
D
A
D
L
F
I
C
E
-
C
N
M
Y
A
HQE
A
---
A
K
A
G
H
M
-
N
S
T
E
V
A
S
I
A
K
D
---
A
N
V
K
E
L
L
L
T
H
L
P
H
T
G
N
----
P
A
D
L
V
T
E
A
K
Q
I
F
-----
S
G
H
I
T
L
A
H
S
G
Y
V
W
N
S
-------------------------------
19
HHSearch
56.41
17%
-89
- C5 -
3KL7
6
?
A:
[24-225]
---------------------------------
T
K
S
G
K
E
L
T
I
T
F
I
------
K
H
-----------
G
S
L
M
L
T
Y
D
-
N
H
S
I
Q
V
D
P
V
S
E
Y
A
----------------------------
D
---------
Y
T
T
F
-
P
K
A
D
I
I
L
I
T
H
E
H
G
D
H
------
L
D
P
K
A
I
Q
A
-
V
E
K
-----------
S
D
T
E
I
I
A
N
E
N
S
Q
-
K
K
L
G
K
---------------------------------
G
K
V
L
K
N
G
D
T
D
T
S
I
-
S
Y
M
K
I
E
A
V
P
A
Y
N
T
T
P
G
R
---------------
D
-
K
----
Y
H
P
R
H
R
D
N
G
Y
I
L
T
F
--
D
G
L
R
V
Y
I
A
G
D
T
E
D
I
P
E
M
--
K
--
D
L
K
------
D
I
D
I
A
F
L
P
-
V
N
Q
P
-----------
Y
T
M
-
T
V
S
Q
A
A
K
A
A
R
M
---
F
S
P
K
I
L
Y
P
Y
H
Y
G
D
T
-----
K
I
G
E
L
K
D
A
L
K
D
S
G
I
D
V
R
I
R
E
L
Q
------------------------------------------
25
HHSearch
53.29
15%
-102
- C5 -
3IEK
15
RNSE_THET8
A:
[1-224]
---------------------------------------
M
R
I
V
P
F
------
G
A
AREVTG-----
S
A
H
L
L
L
A
G
-
G
R
R
V
L
L
D
C
G
M
F
Q
G
K
E
-----------------
E
A
R
------
N
H
--
A
P
F
G
---
F
D
P
-
K
E
V
D
A
V
L
L
T
H
A
H
L
D
H
------
V
--
G
R
L
P
K
L
F
R
E
G
----------
Y
R
G
P
V
Y
A
T
R
A
T
V
-
L
L
M
E
I
V
-
L
E
D
A
L
K
VMDEPF----
F
G
P
E
D
V
E
E
A
---
L
G
H
L
R
P
L
E
Y
G
E
-
W
L
R
L
-
G
A
L
S
L
A
F
G
Q
A
G
H
L
------------------------------
P
G
S
A
F
V
V
A
Q
G
--
E
G
R
T
L
V
Y
S
G
D
L
G
N
R
E
K
D
VL
P
DP
S
L
P
---
P
--
L
A
D
L
V
L
A
E
-
G
T
Y
G
D
---
R
P--
H
R
P
Y
R
E
-
T
V
R
E
F
L
E
I
L
E
K
T
L
S
Q
G
G
K
V
L
I
P
T
F
A
V
E
R
A
Q
E
I
L
Y
V
L
Y
T
H
G
H
R
L
P
R
A
P
I
Y
L
D
S
P
M
A
G
R
V
L
S
L
Y
P
R
L
V
R
Y
F
S
E
E
V
Q
A
H
F
L
Q
G
K
N
P
F
R
P
A
G
L
E
V
V
E
H
T
E
A
26
HHSearch
53.10
19%
-114
- C5 -
2I7T
3
CPSF3_HUMAN
A:
[9-207]
------------------------------------
S
D
Q
L
L
I
R
P
L
------
G
A
GQEVGR-----
S
C
I
I
L
E
F
K
-
G
R
K
I
M
L
D
C
G
I
H
P
G
L
-----------------
E
G
M
-------
D
A
--
L
P
-
Y
I
D
L
I
D
P
-
A
E
I
D
L
L
L
I
S
H
F
H
L
D
H
------
C
--
G
A
L
P
W
F
L
Q
K
T
---------
S
F
K
G
R
T
F
M
T
H
A
T
K
-
A
I
Y
R
W
L
-
L
S
D
Y
VK------------LYT
E
T
D
L
E
E
S
M
D
K
I
E
T
I
N
F
H
E
-
V
K
E
V
-
A
G
I
K
F
W
C
Y
H
A
G
H
V
------------------------------
L
G
A
A
M
F
M
I
E
I
--
A
G
V
K
L
L
Y
T
G
D
F
S
R
Q
---------
M
A
A
E
I
P
N
I
K
P
D
I
L
I
I
E
-
S
T
Y
G
T
---
H
---
I
H
E
K
R
E
-
E
R
E
A
R
F
C
N
T
V
H
---
D
I
V
N
R
G
G
R
G
L
I
P
V
F
A
L
G
R
A
Q
E
L
L
L
I
L
D
E
Y
W
Q
N
H
P
E
L
H
D
I
P
I
Y
Y
A
F
K
H
I
S
N
L
K
S
M
D
H
F
D
D
I
G
P
S
V
V
M
A
S
P
G
M
M
Q
S
G
L
S
R
E
L
F
E
S
38
Fugue
52.56
14%
-60
- C5 -
1ZKP
3
?
A:
[18-268]
L
Y
F
----------------------
Q
S
N
A
M
K
M
T
V
V
G
F
W
G
G
F
P
E
A
G
------
E
A
-----------
T
S
G
Y
L
F
E
H
D
G
F
R
L
L
V
D
C
G
S
G
-------------------------------
V
--
L
A
Q
L
Q
K
Y
I
T
P
-
S
D
I
D
A
V
V
L
S
H
Y
H
H
D
H
VAD
I
G
V
L
Q
Y
A
R
L
I
T
S
A
T
K
G
--------
Q
L
P
E
L
P
I
Y
G
H
T
F
D
E
-
N
G
F
H
S
L
-
T
---------------
H
E
P---------
H
T
K
G
I
P
Y
N
P
E
E
-
T
L
Q
I
-
G
P
F
S
I
S
F
L
K
T
---------------
V
H
P
V
T
C
F
A
M
R
I
T
A
G
-----------------
N
D
I
V
V
Y
S
A
D
S
S
Y
I
P
E
F
--
I
--
P
F
T
---
K
D
A
D
L
F
I
C
E
C
N
M
Y
A
H
Q
E
---
A
----
A
K
A
G
H
M
N
S
T
E
V
A
S
I
A
K
D
---
A
N
V
K
E
L
L
L
T
H
L
P
H
T
G
N
P
A
D
L
V
T
E
A
K
Q
I
F
S
------------------
G
H
I
T
L
A
H
S
G
Y
V
W
N
S
----------------------
31
HHSearch
51.12
13%
-96
- C5 -
2YCB
4
?
A:
[178-380]
-------------------------------------
D
W
A
R
L
T
A
M
GGFREV
G
R
-----------
S
C
L
Y
L
Q
T
P
-
N
S
R
V
L
L
D
C
G
V
N
V
A
G
G
-----------------
D
D
K
N
S
Y
P
Y
--
L
--
N
V
P
---
E
F
T
L
-
D
S
L
D
A
V
I
I
T
H
A
H
L
D
H
------
S
--
G
F
L
P
Y
L
Y
H
Y
G
----------
Y
D
G
P
V
Y
C
T
A
P
T
R
-
D
L
M
T
L
L
-
Q
L
D
H
I
D
I
A
H
R
E
DEPLP
F
N
V
K
H
V
K
K
S
---
V
K
H
T
I
T
L
D
Y
G
E
-
V
T
D
I
A
P
D
I
R
L
T
L
H
N
A
G
H
I
------------------------------
L
G
S
A
M
A
H
L
H
I
GD
G
Q
H
N
M
V
Y
T
G
D
F
K
Y
E
Q
S
R
LL
E
--
A
A
A
N--
R
F
P
R
I
E
T
L
V
M
E
-
S
T
Y
G
G
---
H
---
E
D
V
Q
P
S
-
R
N
R
A
E
K
E
L
V
K
T
---
I
Y
S
T
L
R
R
G
G
K
I
L
I
P
V
F
A
V
G
R
A
Q
E
L
M
I
V
L
E
E
Y
I
R
T
G
I
I
D
E
V
P
V
Y
I
D
G
M
I
W
E
A
N
A
I
H
T
A
R
P
E
Y
L
S
K
D
L
R
D
Q
I
F
H
M
G
H
N
P
F
I
S
D
I
F