@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1849: (2015-12-11 )
MFEKVTISDIANLVGVSKATVSYYLNGNYKKMSLQTKEKIRLAIKETGYQPSKIAQSLVTKNTRTIGVVIADITNPFISSVMKGIHDTCQQFGYSVNFTNSDNDIDIELENLNRLNQQNVSGIILDSVDPNHSFIETLSNDRLVMVDRQAKDIKVDTVASDNKESTQIFLEKMQEAGYHDIYFVTYPIEGISTRELRYEGFKEVVSSNPDKLIIITEDGSTQRILDIIEHSEQKPGFLMMNGPTLLNFMKKLNQSTVSYPEDYGLGSYEDLEWMQVLTPNVSCIKQDSYGIGCLAAQCLIEKISQGNEPTTARLLEVKNQIVIRQSF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120...---...-.130....-.-..-140-.......-.150-.......160.......170.......180.......190-.......200---....--..-----------..----210..---.---.--...220---.........230-.....-....240...-....250.......260.......270.......280.......290.......300.-......310.......320.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFE
K
V
T
I
S
D
I
A
N
L
VGV
S
K
A
T
V
S
Y
Y
LNG
N
Y
K
K
M
S
LQ
T
K
E
K
I
R
L
A
I
KETGY
Q
P
S
K
I
A
Q
S
L
V
TKNT
R
T
I
G
V
V
I
ADIT
N
P
F
I
S
S
V
M
K
G
I
H
D
T
C
Q
QFG
Y
S
V
NFTNSDN
D
I
D
I
E
L
E
N
L
N
R
LNQQNV
S
G
I
I
L
---DSV-DP
N
H
S
F
I
E
-T-LS-ND--
R
L
V
M
V
DR-QAK
D
-
I
K
V
D
T
VASDN
K
E
S
T
Q
I
F
L
E
K
M
Q
EAGYH
D
I
Y
F
V
T
YPIEGIS-
T
R
E
L
R
Y
E
G
F
----
K
E
V
V
--SS-----------NP----
D
K
L
I
I
---
I
---T--EDG
S
-----
T
Q
R
I
L
D
I
I
E
H---SEQKP-
G
F
L
M
MN
G
P
T
L
-
L
N
F
M
K
K
L
N
Q
S
TVSYPEDYGLGSY
E
D
L
E
W
M
Q
VLTPN
V
S
C
I
KQDSY
G
I
G
C
L
A
A
Q
C
L
I
E
K
I
-SQGNEP
T
T
A
R
L
L
E
VK
N
Q
I
V
I
RQSF
1
PsiBlast_PDB
91.65
26%
-85
- C3 -
3OQO
4
CCPA_BACSU
A:
[3-330]
----
I
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
-
G
N
I
-
T
D
E
H
V
A
E
F
-
K
-
R
S
-
P
V
--
P
I
V
L
A
A
S
-
V
E
E
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
-
N
R
S
K
K
L
Q
G
Y
----
K
R
A
L
E
E
A
N
-----------
L
P
F
---
N
E
Q
F
V
---
A
---
E
--
G
D
Y
T
-----
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
-
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
-
N
K
--
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
2
PsiBlast_PDB
90.78
26%
-84
- C3 -
3OQM
4
CCPA_BACSU
A:
[3-330]
----
I
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
-
G
N
I
-
T
D
E
H
V
A
E
F
-
K
-
R
S
-
P
V
--
P
I
V
L
A
A
S
-
V
E
E
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
-
N
R
S
K
K
L
Q
G
Y
----
K
R
A
L
E
E
A
N
-----------
L
P
F
---
N
E
Q
F
V
---
A
---
E
--
G
D
Y
T
-----
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
-
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
-
N
K
--
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
3
PsiBlast_PDB
90.77
26%
-83
- C3 -
3OQN
2
CCPA_BACSU
A:
[3-330]
----
I
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
F
M
G
-
G
N
I
-
T
D
E
H
V
A
E
F
-
K
-
R
S
-
P
V
--
P
I
V
L
A
A
S
-
V
E
E
Q
-
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
-
N
R
S
K
K
L
Q
G
Y
----
K
R
A
L
E
E
A
N
-----------
L
P
F
---
N
E
Q
F
V
---
A
---
E
--
G
D
Y
T
-----
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
-
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
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D
L
D
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D
N
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L
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L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
-
N
K
--
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
15
PsiBlast_PDB
87.36
23%
-84
- C3 -
1BDH
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
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G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
17
PsiBlast_PDB
87.35
23%
-82
- C3 -
1QQA
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
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A
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N
H
T
K
S
I
G
L
L
A
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S
S
E
A
A
Y
F
A
E
I
I
E
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V
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K
N
C
F
Q
K
G
Y
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L
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L
G
N
A
W
N
N
L
E
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Q
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A
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L
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M
M
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Q
K
R
V
D
G
L
L
V
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CS
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Y
P
-
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P
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L
A
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R
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--
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A
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A
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A
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G
G
Y
M
A
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R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
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G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
19
PsiBlast_PDB
87.24
23%
-81
- C3 -
1PNR
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
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E
T
R
N
A
V
W
A
A
I
K
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L
H
Y
S
P
S
A
V
A
R
S
L
K
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N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
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CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
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--
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K
A
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A
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I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
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L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
16
PsiBlast_PDB
87.17
23%
-82
- C3 -
1QP7
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
MCS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
18
PsiBlast_PDB
86.99
23%
-79
- C3 -
1QQB
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
11
PsiBlast_PDB
86.83
23%
-78
- C3 -
2PUA
2
PURR_ECOLI
A:
[1-329]
----
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
10
PsiBlast_PDB
86.81
23%
-77
- C3 -
1JH9
4
PURR_ECOLI
A:
[1-329]
----
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
R
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
14
PsiBlast_PDB
86.80
23%
-82
- C3 -
2PUD
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
13
PsiBlast_PDB
86.69
23%
-79
- C3 -
2PUC
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
12
PsiBlast_PDB
86.63
23%
-82
- C3 -
2PUB
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
6
PsiBlast_PDB
86.63
24%
-83
- C3 -
1RZR
5
CCPA_BACME
D:
[3-330]
----
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
---
M
S
G
-
N
V
T
E
E
H
V
E
-
E
-
L
K
-
K
S
PV
P
V
V
L
A
A
S
-
I
E
S
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
-
N
H
A
K
K
V
K
G
Y
----
K
R
A
L
--
T
E
-----------
S
G
LPVR
D
S
Y
I
V
EGD
Y
---
T
--
Y
D
S
G
-----
I
E
A
V
E
K
L
L
E
E
---
D
E
K
P
T
-
A
I
F
V
G
T
D
E
M
A
-
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
-
N
K
--
E
T
V
D
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
20
PsiBlast_PDB
86.49
23%
-80
- C3 -
1BDI
2
PURR_ECOLI
A:
[2-329]
-----
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
M
CS
E
Y
P
-
E
P
L
L
A
M
L
E
-
E
-
Y
R
-
H
I
--
P
M
V
V
M
D
W
G
E
A
K
A
-
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
-
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
--
I
K
-----------
V
P
----
E
S
W
I
V
---
Q
---
G
DF
E
P
E
S
-----
G
Y
R
A
M
Q
Q
I
L
S
---
Q
P
H
R
P
-
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
---
I
E
V
H
P
R
L
I
E
R
R
S
V
4
PsiBlast_PDB
86.41
24%
-85
- C3 -
1ZVV
4
CCPA_BACSU
A:
[3-330]
----
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
---
M
S
G
-
N
V
T
E
E
H
V
E
-
E
-
L
K
-
K
S
P
V
P
V
V
L
A
A
S
-
I
E
S
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
-
N
H
A
K
K
V
K
G
Y
----
K
R
A
L
--
T
E
-----------
S
G
L
P
V
R
D
S
Y
I
V
E
G
D
Y
---
T
--
Y
D
S
G
-----
I
E
A
V
E
K
L
L
E
E
---
D
E
K
P
T
-
A
I
F
V
G
T
D
E
M
A
-
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
-
N
K
--
E
T
V
D
S
S
I
V
E
L
P
H
R
I
E
F
R
Q
S
T
5
PsiBlast_PDB
85.58
24%
-83
- C3 -
2HSG
-
CCPA_BACME
A:
[3-330]
----
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
-
K
T
T
T
V
G
V
I
I
P
--
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
---
M
S
G
-
N
V
T
E
E
H
V
E
-
E
-
L
K
-
K
S
P
V
P
V
V
L
A
A
S
-
I
E
S
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
-
N
H
A
K
K
V
K
G
Y
----
K
R
A
L
--
T
E
-----------
S
G
LPVR
D
S
Y
I
V
E
G
D
Y
---
T
--
Y
D
S
G
-----
I
E
A
V
E
K
L
L
E
E
---
D
E
K
P
T
-
A
I
F
V
G
T
D
E
M
A
-
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
-
N
K
--
E
T
V
D
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
43
HHSearch
83.53
24%
-78
- C3 -
2HSG
-
CCPA_BACME
A:
[2-331]
---
N
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
-
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
-
K
T
T
T
V
G
V
I
I
P
--
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
I
I
F
---
M
S
G
-
N
V
T
E
E
H
V
E
E
L
-
K
K
S
P
V
--
P
V
V
L
A
A
S
-
I
E
S
T
-
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
-
E
P
I
N
H
A
K
K
V
K
G
Y
----
K
R
A
L
--
T
E
-----------
S
G
----
L
P
V
R
D
---
S
Y
I
V
E
--
G
D
-
Y
T
Y
D
S
G
I
E
A
V
E
K
L
L
E
E
---
D
E
K
P
T
-
A
I
F
V
G
T
D
E
M
A
-
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
-
N
K
E
T
V
D
--
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
50
HHSearch
81.35
22%
-72
- C3 -
1QPZ
2
PURR_ECOLI
A:
[1-330]
----
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
-
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
-
P
L
L
A
M
L
E
E
Y
R
H
I
--
P
M
V
V
M
D
W
-
G
E
A
K
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
-
R
N
-
T
G
A
G
R
L
A
G
F
----
M
K
A
M
--
E
E
-----------
A
M
----
I
K
V
P
E
---
S
W
I
V
Q
--
G
D
-
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
---
P
H
R
P
T
-
A
V
F
C
G
G
D
I
M
A
-
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
-
V
N
K
R
E
E
--
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
8
PsiBlast_PDB
74.72
25%
-73
- C3 -
3CTP
2
?
A:
[60-316]
--------------------------------------------------------------
S
K
T
I
G
L
M
V
P
N
I
S
N
P
F
F
N
Q
M
A
S
V
I
E
E
Y
A
K
N
K
G
Y
T
L
F
L
C
N
T
D
D
D
K
E
K
E
K
T
Y
L
E
V
L
Q
S
H
R
V
A
G
I
I
A
---
S
R
S
-
Q
C
E
D
E
Y
A
N
-
I
----
D
I
--
P
V
V
A
F
E
N
-
H
I
L
D
--
N
I
I
T
I
S
S
D
N
Y
N
G
G
R
M
A
F
D
H
L
Y
E
K
G
C
R
K
I
L
H
I
K
G
P
-
E
V
F
E
-
A
T
E
L
R
Y
K
G
F
----
L
D
G
A
--
R
A
K
D
L
E
I
D
F
I
E
F
Q
H
D
----
F
Q
V
K
M
---
L
---
E
--
E
D
I
N
-----
S
M
K
--
D
I
V
N
Y
---
D
-----
G
I
F
V
F
N
D
I
A
A
-
A
T
V
M
R
A
L
K
K
R
G
V
S
I
P
Q
E
V
Q
I
I
G
F
D
N
S
F
I
G
E
L
L
Y
P
S
L
T
T
I
N
Q
P
I
E
A
L
A
Y
T
I
I
E
L
L
I
K
I
I
-
N
G
E
G
V
L
I
E
D
Y
I
M
E
V
K
L
I
E
R
E
T
T
I
S