@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1862: (2015-12-11 )
MIIDRLLQRSHSHLPILQATFGLERESLRIHQPTQRVAQTPHPKTLGSRNYHPYIQTDYSEPQLELITPIAKDSQEAIRFLKAISDVAGRSINHDEYLWPLSMPPKVREEDIQIAQLEDAFEYDYRKYLEKTYGKLIQSISGIHYNLGLGQELLTSLFELSQADNAIDFQNQLYMKLSQNFLRYRWLLTYLYGASPVAEEDFLDQKLNNPVRSLRNSHLGYVNHKDIRISYTSLKDYVNDLENAVKSGQLIAEKEFYSPVRLRGSKACRNYLEKGITYLEFRTFDLNPFSPIGITQETVDTVHLFLLALLWIDSSSHIDQDIKEANRLNDLIALSHPLEKLPNQAPVSDLVDAMQSVIQHFNLSPYYQDLLESVKRQIQSPELTVAGQLLEMIEGLSLETFGQRQGQIYHDYAWEAPYALKGYETMELSTQLLLFDVIQKGVNFEVLDEQDQFLKLWHNSHIEYVKNGNMTSKDNYIVPLAMANKVVTKKILDEKHFPTPFGDEFTDRKEALNYFSQIQDKPIVVKPKSTNFGLGISIFKTSANLASYEKAIDIAFTEDSAILVEEYIEGTEYRFFVLEGDCIAVLLRVAANVVGDGIHTISQLVKLKNQNPLRGYDHRSPLEVIELGEVEQLMLEQQGYTVNSIPPEGTKIELRRNSNISTGGDSIDVTNTMDPTYKQLAAEMAEAMGAWVCGVDLIIPNATQAYSKDKKNATCIELNFNPLMYMHTYCQEGPGQSITPRILAKLFPEL
Atome Classification :
(20 SA)
..--.......10......-..20........30........40........50........60........70........80........90........100.....-..-110.....----..120---..-.......130.......140.......150......-.160.......170.......180.......190.......200--------....------------..--...----------210-----------..------------.......220.--..--....230.......240-------------------------.------------------------.----------------------..----------------------...250.......260----..-----..-----.-...270.......280.......290.......300.......310.----.....-------.-320.......330..-----------.---------.-----...340.....------..350.......---360..---.....370.......380.......390.......400---........410.......420.......---430.......440.......450......----------------.-----460.......470........480.......490-.......500.--..--....510.....-..520.......530.......540.......550...----.------.------..560.......---570--.-.....--..---.---580.......590.......600.......610.......620.......630.......640.......650.......660.......670........680.......-----690-.-.......700.......710.......720......-.730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
--
I
D
R
L
L
Q
RSHSHLP
I
L
-
Q
A
TFGLERESLRIHQ
P
T
Q
R
V
AQTPHPKTLGSRNYH
P
Y
I
QTDYSEP
Q
L
E
L
ITPIAKD
S
Q
E
A
I
R
F
L
K
A
I
S
D
V
AGRSINHD
E
Y
L
WPLSMPPKV-RE-ED
I
Q
I
A
Q
L
----
E
D
A
-----
F
E
-
Y
D
Y
R
K
Y
L
E
K
T
Y
G
K
L
I
Q
S
I
SGIHYNLGL
G
Q
E
L
L
T
S
L
F
-
E
L
SQADNA
I
D
F
Q
N
Q
L
Y
M
K
L
S
Q
N
F
L
R
Y
R
W
L
L
T
Y
L
YGASPV
A
E
E
----------
D
F
L
D
------------
Q
K
--LN
N
----------
P
-------------
V
R
------------
S
L
R
N
SHLG
Y
V
N--H
K
--
D
I
R
I
S
Y
T
S
L
K
D
Y
V
N
D
L
E
-------------------------
N
------------------------
A
----------------------
V
K----------------------SG
Q
L
I
A
E
KEFYS
P
V
R-----LR-----
G
S
-----
K
-
A
C
R
N
Y
L
E
KG
I
T
Y
L
E
F
R
T
FDLNPFSPIGI
T
Q
E
T
V
D
T
V
H
L
F
L
L
A
L
L
WID----S
S
S
H
I
-------
D
-
Q
D
I
K
E
A
N
R
L
N
D
L
I
AL-----------S---------
H
-----
P
L
E
KLPNQA
P
V
------
S
D
L
V
D
A
M
Q
S
V
I
Q
---HFNL
S
---
P
Y
Y
Q
D
L
L
E
S
V
K
R
Q
IQSP
E
L
T
V
A
G
Q
L
L
E
M
I
EGLS
L
E
T
F
----
G
Q
RQ
G
Q
I
Y
H
DYAWEAPYALKG
Y
E
T
M
E
L
S
---
T
Q
L
L
L
F
D
V
I
Q
KGV
N
F
E
V
LDE
Q
D
Q
F
L
K
L
W
H
----------------N-----SH
I
E
Y
VKNGNMT-SKD
N
Y
I
V
P
L
A
MA
N
K
V
V
T
K
K
I
L-DEKHFPTPFGD--EF--T
D
R
K
E
A
L
N
Y
F
S
Q-IQDK
P
I
V
V
KPKSTNF
G
L
G
I
S
I
F
KTSANLASY
E
K
A
I
D
I
A
----F------T------ED
S
A
I
L
V
E
E
YIE---G----T-
E
Y
R
F
F
--
V
L---E---G
D
C
I
A
V
L
L
R
V
A
A
N
V
VG
D
G
I
H
T
I
S
Q
L
V
K
LKNQNPLRGYDHRSP
L
E
V
I
E
LG
E
V
E
Q
L
M
L
E
QQG
Y
T
VNSIPPEG
T
K
I
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L
R
RNSNISTGGD
S
I
D
VT-NTM
D
P
T
Y
K
Q
L
A
A
E
M
A
E
A
M
G
-----
A
-
W
-V-CG
V
D
L
IIPN
A
T
Q
A
YSKDKKN
A
T
C
I
E
LNFN
P
L
M
Y
M
H
T
-
Y
C
QEGPGQS
I
T
P
R
I
L
A
K
LFPEL--
53
Fugue
99.72
99%
-95
- C2 -
3LN6
1
GSHAB_STRA5
A:
[4-750]
-----
D
R
L
L
Q
R
S
H
S
H
L
P
I
L
-
Q
A
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L
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P
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M
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-
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Q
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A
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----
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D
A
-----
F
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-
Y
D
Y
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K
Y
L
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G
K
L
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Q
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I
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N
L
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L
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A
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A
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----------
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L
D
------------
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K
--
L
N
N
----------
P
-------------
V
R
------------
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L
R
N
S
H
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G
Y
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--
H
K
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Y
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N
D
L
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-------------------------
N
------------------------
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V
K
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G
Q
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--
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K
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P
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-----
L
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-----
G
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K
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-------
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K
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A
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L
N
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L
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A
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-----------
S
---------
H
-----
P
L
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K
L
P
N
Q
A
P
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------
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D
A
M
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Q
---
H
F
N
L
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---
P
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L
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----
G
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Y
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A
W
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M
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---
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Q
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N
F
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Q
D
Q
F
L
K
L
W
H
----------------
N
-----
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K
N
G
N
M
T
-
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K
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G
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K
T
S
A
N
L
A
S
Y
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K
A
I
D
I
A
----
F
------
T
------
E
D
S
A
I
L
V
E
E
Y
I
E
---
G
----
T
-
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Y
R
F
F
--
V
L
---
E
---
G
D
C
I
A
V
L
L
R
V
A
A
N
V
V
G
D
G
I
H
T
I
S
Q
L
V
K
L
K
N
Q
N
P
L
R
G
Y
D
H
R
S
P
L
E
V
I
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L
G
E
V
E
Q
L
M
L
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Q
Q
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Y
T
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N
S
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P
P
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G
T
K
I
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L
R
R
N
S
N
I
S
T
G
G
D
S
I
D
V
T
-
N
T
M
D
P
T
Y
K
Q
L
A
A
E
M
A
E
A
M
G
-----
A
-
W
-
V
-
C
G
V
D
L
I
I
P
N
A
T
Q
A
Y
S
K
D
K
K
N
A
T
C
I
E
L
N
F
N
P
L
M
Y
M
H
T
-
Y
C
Q
E
G
P
G
Q
S
I
T
P
R
I
L
A
K
L
F
P
E
L
--
1
PsiBlast_PDB
99.07
100%
-95
- C2 -
3LN6
1
GSHAB_STRA5
A:
[4-750]
-----
D
R
L
L
Q
R
S
H
S
H
L
P
I
L
-
Q
A
T
F
G
L
E
R
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S
L
R
I
H
Q
P
T
Q
R
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A
Q
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S
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P
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S
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Q
L
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L
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K
D
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Q
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L
K
A
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V
A
G
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N
H
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L
W
P
L
S
M
P
P
K
V
-
R
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-
E
D
I
Q
I
A
Q
L
----
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D
A
-----
F
E
-
Y
D
Y
R
K
Y
L
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T
Y
G
K
L
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Q
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I
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Y
N
L
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L
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L
L
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-
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Y
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A
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A
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----------
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L
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------------
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--
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N
N
----------
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-------------
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------------
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--
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----
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-------
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-----------
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M
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---
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Q
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K
L
W
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----------------
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-----
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A
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---
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---
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A
A
N
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D
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N
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Y
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L
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G
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L
M
L
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Q
Q
G
Y
T
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N
S
I
P
P
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G
T
K
I
E
L
R
R
N
S
N
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T
G
G
D
S
I
D
V
T
-
N
T
M
D
P
T
Y
K
Q
L
A
A
E
M
A
E
A
M
G
-----
A
-
W
-
V
-
C
G
V
D
L
I
I
P
N
A
T
Q
A
Y
S
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K
K
N
A
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N
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P
L
M
Y
M
H
T
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Y
C
Q
E
G
P
G
Q
S
I
T
P
R
I
L
A
K
L
F
P
E
L
--
30
HHSearch
96.55
96%
-92
- C2 -
3LN6
1
GSHAB_STRA5
A:
[4-750]
-----
D
R
L
L
Q
R
S
H
S
H
L
P
I
L
-
Q
A
T
F
G
L
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R
S
I
N
H
D
E
Y
L
W
P
L
S
M
P
P
K
V
-
R
--
E
E
D
I
Q
I
A
Q
----
L
E
D
-----
A
F
E
Y
D
Y
R
K
Y
L
E
K
T
Y
G
K
L
I
Q
S
I
S
G
I
H
Y
N
L
G
L
G
Q
E
L
L
T
S
L
F
-
E
L
S
Q
A
D
N
A
I
D
F
Q
N
Q
L
Y
M
K
L
S
Q
N
F
L
R
Y
R
W
L
L
T
Y
L
Y
G
A
S
P
V
A
E
E
----------
D
F
L
D
------------
Q
K
--
L
N
N
----------
P
-------------
V
R
------------
S
L
R
N
S
H
L
G
Y
V
N
--
H
K
--
D
I
R
I
S
Y
T
S
L
K
D
Y
V
N
D
L
E
N
A
V----------------------
K
------------------------
S
----------------------
G
Q
---------------------------
A
E
K
E
F
Y
S
P
V
R
-----
L
R
-----
G
S
-----
K
-
A
C
R
N
Y
L
E
K
G
I
T
Y
L
E
F
R
T
F
D
L
N
P
F
S
P
I
G
I
T
Q
E
T
V
D
T
V
H
L
F
L
L
A
L
L
W
I
D
----
S
--
H
I
-------
D
Q
D
I
K
E
A
N
R
L
N
D
L
I
-
A
L
-----------
S
---------
H
-----
P
L
E
K
L
P
N
Q
A
P
V
------
S
D
L
V
D
A
M
Q
S
V
I
Q
---
H
F
N
L
S
---
P
Y
Y
Q
D
L
L
E
S
V
K
R
Q
I
Q
S
P
E
L
T
V
A
G
Q
L
L
E
M
I
E
G
L
S
L
E
T
F
----
G
Q
R
Q
G
Q
I
Y
H
D
Y
A
W
E
A
P
Y
A
L
K
G
Y
E
T
M
E
L
S
---
T
Q
L
L
L
F
D
V
I
Q
K
G
V
N
F
E
V
L
D
E
Q
D
Q
F
L
K
L
W
H
----------------
N
-----
S
H
I
E
Y
V
K
N
G
N
M
T
-
S
K
D
N
Y
I
V
P
L
A
M
A
N
K
V
V
T
K
K
I
L
-
D
E
K
H
F
P
T
P
F
G
D
--
E
F
--
T
D
R
K
E
A
L
N
Y
F
S
Q
I
Q
-
D
K
P
I
V
V
K
P
K
S
T
N
F
G
L
G
I
S
I
F
K
T
S
A
N
L
A
S
Y
E
K
A
I
D
I
A
----
F
------
T
------
E
D
S
A
I
L
V
E
E
Y
I
E
---
G
----
T
-
E
Y
R
F
F
--
V
L
---
E
---
G
D
C
I
A
V
L
L
R
V
A
A
N
V
V
G
D
G
I
H
T
I
S
Q
L
V
K
L
K
N
Q
N
P
L
R
G
Y
D
H
R
S
P
L
E
V
I
E
L
G
E
V
E
Q
L
M
L
E
Q
Q
G
Y
T
V
N
S
I
P
P
E
G
T
K
I
E
L
R
R
N
S
N
I
S
T
G
G
D
S
I
D
V
T
-
N
T
M
D
P
T
Y
K
Q
L
A
A
E
M
A
E
A
M
G
-----
A
-
W
-
V
-
C
G
V
D
L
I
I
P
N
A
T
Q
A
Y
S
K
D
K
K
N
A
T
C
I
E
L
N
F
N
P
L
M
Y
M
H
T
-
Y
C
Q
E
G
P
G
Q
S
I
T
P
R
I
L
A
K
L
F
P
E
L
--
54
Fugue
60.84
29%
-66
- C2 -
1VA6
7
GSH1_ECOLI
A:
[1-515]
M
I
PD
V
S
Q
A
L
A
W
L
E
K
H
P
Q
A
L
K
G
I
Q
R
G
L
E
R
E
T
L
R
V
-
N
A
D
G
T
L
A
T
T
G
H
P
E
A
L
G
S
A
L
T
H
K
W
I
T
T
D
F
A
E
A
L
L
E
F
I
T
P
V
D
G
D
I
E
H
M
L
T
F
M
R
D
L
H
R
Y
T
A
R
N
M
G
-
D
E
R
M
W
P
L
S
M
P
S
Y
I
A
E
G
-
Q
D
I
E
L
A
Q
Y
G
TS
N
T
G
R
-----
F
K
-
T
L
Y
R
E
G
L
K
N
R
Y
G
A
L
M
Q
T
I
S
G
V
H
Y
N
F
S
L
P
M
A
F
W
Q
A
K
S
-
G
D
I
S
G
A
D
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
W
V
I
P
Y
L
F
G
A
S
P
A
I
S
S
----------
S
F
L
T
------------
S
L
--
P
F
E
K
T
ESG
M
Y
Y
L
P
Y
-------------
A
T
------------
S
L
R
L
S
D
L
G
Y
T
N
--
K
S
QS
N
L
G
I
T
F
N
D
L
Y
E
Y
V
A
G
L
K
-------------------------
Q
------------------------
A
----------------------
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQIN-
S
N
V
L
Q
I
E
N
E
L
Y
A
P
I
R
-----
P
K
R
VTRS
G
E
-----
S
-
P
S
D
A
L
L
R
G
G
I
E
Y
I
E
V
R
S
L
D
I
N
P
F
S
P
I
G
V
D
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
----
A
P
E
M
S
-------
S
-
S
E
L
A
C
T
R
V
N
W
N
R
V
I
L
EGRKPG
L
T
L
G
I
G
---------
C
-----
E
T
A
Q
F
P
L
P
Q
V
G
------
K
D
L
F
R
D
L
K
R
V
A
Q
---
T
L
D
S
I
N
GG
E
A
Y
Q
K
V
C
D
E
L
V
A
C
F
D
N
P
D
L
T
F
S
A
R
I
L
R
S
M
I
D
----
T
T
----
G
K
A
F
A
E
A
Y
R
N
L
L
R
E
E
P
L
E
I
L
R
E
E
D
F
V
A
E
---
R
E
----
A
S
E
R
R
Q
Q
E
M
E
A
A
D
T
E
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
V
W
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
58.58
29%
-68
- C2 -
1VA6
7
GSH1_ECOLI
A:
[25-479]
------------------------
G
L
E
R
E
T
L
R
V
N
A
D
G
T
-
L
A
T
T
G
H
P
E
A
L
G
S
A
L
T
H
K
W
I
T
T
D
F
A
E
A
L
L
E
F
I
T
P
V
D
G
D
I
E
H
M
L
T
F
M
R
D
L
H
R
Y
T
A
R
N
M
G
-
D
E
R
M
W
P
L
S
M
P
S
Y
I
-
A
E
G
Q
D
I
E
L
A
Q
Y
----
G
T
S
N
T
G
R
-
F
K
-
T
L
Y
R
E
G
L
K
N
R
Y
G
A
L
M
Q
T
I
S
G
V
H
Y
N
F
S
L
P
M
A
F
W
Q
A
K
S
G
D
I
S
G
A
D
-
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
W
V
I
P
Y
L
F
G
A
S
P
A
I
S
S
----------
S
F
L
------------------
T
S
L---------
P
F
E
K
T
ESG
M
Y
Y
L
PY
A
T
------------
S
L
R
L
S
D
L
G
Y
T
N
KS
Q
S
--
N
L
G
I
T
F
N
D
L
Y
E
Y
V
A
G
L
K
-------------------------
Q
------------------------
A
----------------------
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQIN-
S
N
V
L
Q
I
E
N
E
L
Y
A
P
I
R
-----
P
K
R
VTRS
G
E
-----
S
-
P
S
D
A
L
L
R
G
G
I
E
Y
I
E
V
R
S
L
D
I
N
P
F
S
P
I
G
V
D
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
A
P
EM
S
S
S
E
L
A
C
T
R
V
N
W
N
-
R
V
I
L
E
G
R
K
P
G
L
T
L
G
I
-----------
G
---------
C
-----
E
T
A
Q
F
P
L
P
Q
V
G
------
K
D
L
F
R
D
L
K
R
V
A
Q
T
L
D
S
I
N
G
G
---
E
A
Y
Q
K
V
C
D
E
L
V
A
C
F
D
N
P
D
L
T
F
S
A
R
I
L
R
S
M
I
D
T
----
T
----
G
K
A
F
A
E
A
Y
R
N
L
L
R
E
E
P
L
E
I
L
R
E
E
D
F
V
A
E
---
R
E
A
S
E
R
R
Q
Q
E
M
E
A
A
D
T
E
P
F
A
V
W
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.14
29%
-70
- C2 -
2D33
8
GSH1_ECOLI
A:
[25-479]
------------------------
G
L
E
R
E
T
L
R
V
N
A
D
G
T
-
L
A
T
T
G
H
P
E
A
L
G
S
A
L
T
H
K
W
I
T
T
D
F
A
E
A
L
L
E
F
I
T
P
V
D
G
D
I
E
H
M
L
T
F
M
R
D
L
H
R
Y
T
A
R
N
M
G
-
D
E
R
M
W
P
L
S
M
P
S
Y
I
-
A
E
G
Q
D
I
E
L
A
Q
Y
----
G
T
S
N
T
G
R
-
F
K
-
T
L
Y
R
E
G
L
K
N
R
Y
G
A
L
M
Q
T
I
S
G
V
H
Y
N
F
S
L
P
M
A
F
W
Q
A
K
S
G----
A
D
-
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
W
V
I
P
Y
L
F
G
A
S
P
A
I
S
S
----------
S
F
L
------------------
T
S
L---------
P
F
E
K
T
ESG
M
Y
Y
L
PY
A
T
------------
S
L
R
L
S
D
L
G
Y
T
N
KS
Q
S
--
N
L
G
I
T
F
N
D
L
Y
E
Y
V
A
G
L
K
-------------------------
Q
------------------------
A
----------------------
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQIN-
S
N
V
L
Q
I
E
N
E
L
Y
A
P
I
R
-----
P
K
R
VTRS
G
E
-----
S
-
P
S
D
A
L
L
R
G
G
I
E
Y
I
E
V
R
S
L
D
I
N
P
F
S
P
I
G
V
D
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
APEM
S
S
S
E
L
A
C
T
R
V
N
W
N
-
R
V
I
L
E
G
R
K
P
G
L
T
L
G
I
-----------
G
---------
C
-----
E
T
A
Q
F
P
L
P
Q
V
G
------
K
D
L
F
R
D
L
K
R
V
A
Q
T
L
D
S
I
N
G
G
---
E
A
Y
Q
K
V
C
D
E
L
V
A
C
F
D
N
P
D
L
T
F
S
A
R
I
L
R
S
M
I
D
T
G
I
G
G
T
----
G
K
A
F
A
E
A
Y
R
N
L
L
R
E
E
P
L
E
I
L
R
E
E
D
F
V
A
E
---
R
E
A
S
E
R
R
Q
Q
E
M
E
A
A
D
T
E
P
F
A
V
W
L
E
K
H
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.11
29%
-70
- C2 -
2D32
7
GSH1_ECOLI
A:
[25-479]
------------------------
G
L
E
R
E
T
L
R
V
N
A
D
G
T
-
L
A
T
T
G
H
P
E
A
L
G
S
A
L
T
H
K
W
I
T
T
D
F
A
E
A
L
L
E
F
I
T
P
V
D
G
D
I
E
H
M
L
T
F
M
R
D
L
H
R
Y
T
A
R
N
M
G
-
D
E
R
M
W
P
L
S
M
P
S
Y
I
-
A
E
G
Q
D
I
E
L
A
Q
Y
----
G
T
S
N
T
G
R
-
F
K
-
T
L
Y
R
E
G
L
K
N
R
Y
G
A
L
M
Q
T
I
S
G
V
H
Y
N
F
S
L
P
M
A
F
W
Q
A
K
S
G----
A
D
-
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
W
V
I
P
Y
L
F
G
A
S
P
A
I
S
S
----------
S
F
L
------------------
T
S
L---------
P
F
E
K
T
ESG
M
Y
Y
L
PY
A
T
------------
S
L
R
L
S
D
L
G
Y
T
N
K
S
Q
S
--
N
L
G
I
T
F
N
D
L
Y
E
Y
V
A
G
L
K
-------------------------
Q
------------------------
A
----------------------
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQIN-
S
N
V
L
Q
I
E
N
E
L
Y
A
P
I
R
-----
P
K
R
VTRS
G
E
-----
S
-
P
S
D
A
L
L
R
G
G
I
E
Y
I
E
V
R
S
L
D
I
N
P
F
S
P
I
G
V
D
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
APEM
S
S
S
E
L
A
C
T
R
V
N
W
N
-
R
V
I
L
E
G
R
K
P
G
L
T
L
G
I
-----------
G
---------
C
-----
E
T
A
Q
F
P
L
P
Q
V
G
------
K
D
L
F
R
D
L
K
R
V
A
Q
T
L
D
S
I
N
G
G
---
E
A
Y
Q
K
V
C
D
E
L
V
A
C
F
D
N
P
D
L
T
F
S
A
R
I
L
R
S
M
I
D
T
G
I
G
G
T
----
G
K
A
F
A
E
A
Y
R
N
L
L
R
E
E
P
L
E
I
L
R
E
E
D
F
V
A
E
---
R
E
A
S
E
R
R
Q
Q
E
M
E
A
A
D
T
E
P
F
A
V
W
L
E
K
H
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
57.86
28%
-70
- C2 -
3NZT
12
?
A:
[26-525]
-------------
Y
D
F
K
K
I
-
N
N
L
R
G
I
E
R
E
T
L
R
V
T
-
D
C
G
N
L
A
T
S
N
H
P
D
G
L
G
H
K
L
T
N
N
S
I
T
V
D
F
S
E
N
L
L
E
L
I
T
K
P
H
D
S
I
D
K
A
I
G
E
L
Y
Q
L
S
A
F
T
L
D
N
M
H
S
D
E
I
I
L
N
T
S
M
P
L
S
A
-
N
D
-
N
D
I
Q
E
A
D
F
GSS
N
S
G
R
-----
M
K
-
R
V
Y
R
K
G
L
S
A
R
Y
G
K
I
M
Q
I
I
S
G
I
H
Y
N
F
S
F
D
K
D
L
I
S
N
I
A
-
T
N
K
Q
-----
V
S
I
S
D
I
Y
F
D
V
L
N
N
Y
F
E
F
M
W
L
L
P
Y
L
F
G
A
S
P
I
C
A
K
----------
T
S
V
K
------------
N
K
--
P
D
Y
----------
L
-------------
S
V
LDDKFYVGEYAT
S
L
R
M
S
D
L
G
S
P
A
--
Q
K
--
D
L
A
I
S
Y
D
N
V
K
A
Y
V
K
D
L
I
-------------------------
Q
------------------------
A
----------------------
T
D
DTF
A
D
Y
K
R
I
GLYNSQGQRIQLN
D
G
I
L
Q
I
E
N
E
Y
Y
S
A
I
R
-----
P
K
Q
IAKR
G
E
-----
R
-
P
A
C
A
L
Y
N
R
G
V
E
Y
V
E
V
R
V
L
D
V
D
P
F
E
P
V
G
I
S
K
D
T
A
L
F
V
E
V
M
L
M
T
C
L
D
K
D
----
A
K
K
Y
H
-------
K
-
D
I
I
K
Q
A
K
Q
N
L
T
A
V
A
I
QGRNP------
Q
---------
L
-----
K
L
K
K
L
D
D
D
S
E
I
L
L
K
D
Y
A
L
E
L
F
D
E
I
E
A
V
A
K
-----
K
M
P
---
K
E
Y
L
D
A
V
E
I
Q
K
R
K
V
L
D
I
S
Q
T
P
S
A
K
I
I
E
L
A
R
Q
H
G
Y
K
K
F
----
I
L
D
I
S
R
R
V
S
Q
Q
F
R
S
Y
E
--
L
P
A
A
I
V
A
K
L
K
---
D
Q
A
G
Q
S
V
A
A
E
K
E
L
V
A
N
D
K
I
S
L
D
E
Y
I
N
R
Y
Y
----------------
K
-----
S
S
K
G
C
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
57.54
29%
-70
- C2 -
1V4G
-
GSH1_ECOLI
A:
[25-479]
------------------------
G
L
E
R
E
T
L
R
V
N
A
D
G
T
-
L
A
T
T
G
H
P
E
A
L
G
S
A
L
T
H
K
W
I
T
T
D
F
A
E
A
L
L
E
F
I
T
P
V
D
G
D
I
E
H
M
L
T
F
M
R
D
L
H
R
Y
T
A
R
N
M
G
-
D
E
R
M
W
P
L
S
M
P
S
Y
I
-
A
E
G
Q
D
I
E
L
A
Q
Y
----
G
T
S
N
T
G
R
-
F
K
-
T
L
Y
R
E
G
L
K
N
R
Y
G
A
L
M
Q
T
I
S
G
V
H
Y
N
F
S
L
P
M
A
F
W
Q
A
K
S
G----
A
D
-
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
W
V
I
P
Y
L
F
G
A
S
P
A
I
S
S
----------
S
F
L
-------------------
S
L---------
P
F
E
K
T
ESG
M
Y
Y
L
PY
A
T
------------
S
L
R
L
S
D
L
G
Y
T
N
KS
Q
S
--
N
L
G
I
T
F
N
D
L
Y
E
Y
V
A
G
L
K
-------------------------
Q
------------------------
A
----------------------
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQIN-
S
N
V
L
Q
I
E
N
E
L
Y
A
P
I
R
-----
P
K
R
VTRS
G
E
-----
S
-
P
S
D
A
L
L
R
G
G
I
E
Y
I
E
V
R
S
L
D
I
N
P
F
S
P
I
G
V
D
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
A
P
E
M
S
S
S
E
L
A
C
T
R
V
N
W
N
-
R
V
I
L
E
G
R
K
P
G
L
T
L
G
I
-----------
G
---------
C
-----
E
T
A
Q
F
P
L
P
Q
V
G
------
K
D
L
F
R
D
L
K
R
V
A
Q
T
L
D
S
I
N
G
G
---
E
A
Y
Q
K
V
C
D
E
L
V
A
C
F
D
N
P
D
L
T
F
S
A
R
I
L
R
S
M
I
D
T
G
I
G
G
T
----
G
K
A
F
A
E
A
Y
R
N
L
L
R
E
E
P
L
E
I
L
R
E
E
D
F
V
A
E
---
R
E
A
S
E
R
R
Q
Q
E
M
E
A
A
D
T
E
P
F
A
V
W
L
E
K
H
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.44
29%
-67
- C2 -
3NZT
12
?
A:
[36-484]
------------------------
G
I
E
R
E
T
L
R
V
T
D
-
C
G
N
L
A
T
S
N
H
P
D
G
L
G
H
K
L
T
N
N
S
I
T
V
D
F
S
E
N
L
L
E
L
I
T
K
P
H
D
S
I
D
K
A
I
G
E
L
Y
Q
L
S
A
F
T
L
D
N
M
H
S
D
E
I
I
L
N
T
S
M
P
L
S
A
-
N
D
-
N
D
I
Q
E
A
D
F
----
G
S
S
N
S
G
R
-
M
K
-
R
V
Y
R
K
G
L
S
A
R
Y
G
K
I
M
Q
I
I
S
G
I
H
Y
N
F
S
F
D
K
D
L
I
S
N
I
------
A
T
N
K
Q
V
S
I
S
D
I
Y
F
D
V
L
N
N
Y
F
E
F
M
W
L
L
P
Y
L
F
G
A
S
P
I
C
A
K
TSVKNKPDYL
S
V
L
D
------------
D
K
FY
V
G
E
----------
Y
-------------
A
T
------------
S
L
R
M
S
D
L
G
--
S
PA
Q
K
--
D
L
A
I
S
Y
D
N
V
K
A
Y
V
K
D
L
I
-------------------------
Q
------------------------
A
T
D
DTF
A
D
Y
K
R
I
GLYNSQGQRIQ
L
N
----------------------
D
G
I
L
Q
I
E
N
E
Y
Y
S
A
I
R
P
K
Q
IA
K
R
-----
G
E
-----
R
P
A
C
A
L
Y
-
N
R
G
V
E
Y
V
E
V
R
V
L
D
V
D
P
F
E
P
V
G
I
S
K
D
T
A
L
F
V
E
V
M
L
M
T
C
L
D
K
D
----
A
K
K
Y
H
-------
K
-
D
I
I
K
Q
A
K
Q
N
L
T
A
V
A
I
-----------
Q
---------
G
RNPQ
L
K
L
K
K
L
D
D
D
S
E
I
L
L
K
D
Y
A
L
E
L
F
D
E
I
E
A
V
A
K
---
K
--
M
P
---
K
E
Y
L
D
A
V
E
I
Q
K
R
K
V
L
D
I
S
Q
T
P
S
A
K
I
I
E
L
A
R
Q
H
G
Y
K
K
F
I
L
D
I
S
R
R
V
S
Q
Q
F
R
S
Y
--
E
L
P
A
A
I
V
A
K
L
K
D
Q
A
G
---
Q
S
V
A
A
E
K
E
L
V
A
N
D
K
I
S
L
D
E
Y
I
N
R
Y
Y
K
S
S
K
----------------
G
-----
C
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
54.33
29%
-61
- C2 -
1VA6
7
GSH1_ECOLI
A:
[16-486]
--------------
P
Q
A
L
K
-
G
I
Q
R
G
L
E
R
E
T
L
R
V
N
A
D
G
-
T
L
A
T
T
G
H
P
E
A
L
G
S
A
L
T
H
K
W
I
T
T
D
F
A
E
A
L
L
E
F
I
T
P
V
D
G
D
I
E
H
M
L
T
F
M
R
D
L
H
R
Y
T
A
R
N
M
-
G
D
E
R
M
W
P
L
S
M
P
S
Y
I
-
A
E
-
G
Q
D
I
E
L
A
Q
----
Y
G
T
S
N
T
G
R
F
K
-
T
L
Y
R
E
G
L
K
N
R
Y
G
A
L
M
Q
T
I
S
G
V
H
Y
N
F
S
L
P
M
A
F
W
Q
A
K
S
-
G
D
I
S
G
A
D
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
W
V
I
P
Y
L
F
G
A
S
P
A
I
S
S
----------
S
F
L
-TSLP
F
E
K
T
ESG-
M
Y
--
Y
L
P
----------
Y
-------------
A
T
------------
S
L
R
L
S
D
L
G
Y
T
N
--
K
S
QS
N
L
G
I
T
F
N
D
L
Y
E
Y
V
A
G
L
K
-------------------------
Q
A
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQIN
S
----------------------
N
V
----------------------
L
---
Q
I
E
N
E
L
Y
A
P
I
R
-----
P
K
-----
R
V
TRSGE
S
-
P
S
D
A
L
L
R
G
G
I
E
Y
I
E
V
R
S
L
D
I
N
P
F
S
P
I
G
V
D
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
----
A
P
E
M
S
-------
S
-
S
E
L
A
C
T
R
V
N
W
N
R
V
I
L
-----------
E
GRKPG
L
T
L
G
I
GC---
E
T
A
Q
F
P
L
P
Q
V
G
------
K
D
L
F
R
D
L
K
R
V
A
Q
---
T
L
D
S
I
N
GG
E
A
Y
Q
K
V
C
D
E
L
V
A
C
F
D
N
P
D
L
T
F
S
A
R
I
L
R
S
M
I
D
T
----
T
----
G
K
A
F
A
E
A
Y
R
N
L
L
R
E
E
P
L
E
I
L
R
E
E
D
F
V
A
E
---
R
E
A
S
E
R
R
Q
Q
E
M
E
A
A
D
T
E
P
F
A
V
W
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
53.35
28%
-68
- C2 -
3NZT
12
?
A:
[31-523]
------------------
I
-
N
N
L
R
G
I
E
R
E
T
L
R
V
T
D
C
G
-
N
L
A
T
S
N
H
P
D
G
L
G
H
K
L
T
N
N
S
I
T
V
D
F
S
E
N
L
L
E
L
I
T
K
P
H
D
S
I
D
K
A
I
G
E
L
Y
Q
L
S
A
F
T
L
D
N
M
H
S
D
E
I
I
L
N
T
S
M
P
L
S
A
--
N
-
D
N
D
I
Q
E
A
D
----
F
G
S
S
N
S
G
R
M
K
-
R
V
Y
R
K
G
L
S
A
R
Y
G
K
I
M
Q
I
I
S
G
I
H
Y
N
F
S
F
D
K
D
L
I
S
N
I
A
-
T
N
K
-----
Q
V
S
I
S
D
I
Y
F
D
V
L
N
N
Y
F
E
F
M
W
L
L
P
Y
L
F
G
A
S
P
I
C
A
K
----------
T
S
V
K
NKPDYLSVLDDK
F
Y
--
V
G
E
----------
Y
-------------
A
T
------------
S
L
R
M
S
D
L
G
--
S
--
P
A
QK
D
L
A
I
S
Y
D
N
V
K
A
Y
V
K
D
L
I
Q
A
T
D
DTF
A
D
Y
K
R
I
GLYNSQGQRIQL
N
------------------------
D
----------------------
G
I
----------------------
L
---
Q
I
E
N
E
Y
Y
S
A
I
R
-----
P
K
-----
Q
I
AKRGE
R
-
P
A
C
A
L
Y
N
R
G
V
E
Y
V
E
V
R
V
L
D
V
D
P
F
E
P
V
G
I
S
K
D
T
A
L
F
V
E
V
M
L
M
T
C
L
D
K
D
----
A
K
K
Y
H
-------
K
-
D
I
I
K
Q
A
K
Q
N
L
T
A
V
A
I
QGRNPQ
L
K
L
K
K
L
---------
D
-----
D
D
S
E
I
L
L
K
D
Y
A
------
L
E
L
F
D
E
I
E
A
V
A
K
---
K
M
P
K
-----
E
Y
L
D
A
V
E
I
Q
K
R
K
V
L
D
I
S
Q
T
P
S
A
K
I
I
E
L
A
R
Q
H
G
Y
K
K
F
----
I
L
D
I
S
R
R
V
S
Q
Q
----------
F
R
S
Y
E
L
P
---
A
A
I
V
A
K
----------
L
K
D
Q
A
G
Q
S
V
A
A
E
K
-------------------------
E
L
V
A
N
D
-
K
I
-
S
L
D
E
Y
I
N
R
Y
Y
K
S
S
K
G
C
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
49.76
22%
-66
* C2 *
3VPD
3
LYSX_THET8
A:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
E
R
M
L
F
E
R
A
E
A
L
G
L
P
Y
K
K
V
Y
V
P
A
L
P
M
V
L
G
E
RPEALEGVT
V
A
L
E
R
C
V
S
Q
S
R
G
L
A
A
A
R
Y
L
T
A
L
G
I
P
-
V
V
N
R
P
E
V
I
E
A
C
G
D
K
W
A
T
S
V
A
L
-
A
K
A
G
L
P
Q
P
K
T
A
--
L
A
--
T
D
R
E
E
A
L
R
L
M
E
A
-
F
-
G
Y
P
V
V
L
K
P
V
I
G
S
W
G
R
L
L
A
K
V
T
D
---
R
A
A
A
E
A
L
L
E
H
K
----
E
V
LGG--
F
------
Q
H
Q
L
F
Y
I
Q
E
Y
V
E
---
K
PG--
R
-
D
I
R
V
F
--
V
V
---
G
---
E
R
A
I
A
A
I
Y
R
R
S
A
H
--------------------
W
I
-------------------------------------------
T
N
T
A
R
G
G
Q
A
E
N
---
C
P
L
T
E
E
I
A
R
L
S
V
G
A
A
E
A
V
G
-----
G
-
G
-
V
-
V
A
V
D
L
F
E
S
E
---------
R
G
L
L
V
N
E
V
N
H
T
M
E
F
K
N
S
V
-
H
---
T
T
G
V
D
I
P
G
E
I
L
R
Y
A
W
E
V
A
--
42
HHSearch
45.32
14%
-81
- C2 -
1KJQ
11
PURT_ECOLI
A:
[64-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
--------------------------
I
Q
L
E
E
E
G
L
N
-
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
--
F
A
--
D
S
E
S
L
F
R
E
A
V
A
D
-
I
-
G
Y
P
C
I
V
K
P
V
M
S
---
K
G
Q
T
F
I
R
---
S
A
E
Q
L
A
Q
A
W
K
Y
A
----
Q
------
Q
G
GRA--
G
A
G
R
V
I
V
E
G
V
V
K
F--
D
----
F
-
E
I
T
L
L
--
T
V
S
A
V
D
---
G
V
H
F
C
A
P
V
G
H
R
Q
---
E
D
G
--------------
D
Y
R
---------------------------
E
S
W
Q
P
--------------------
Q
Q
M
S
-
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
-----
G
-
Y
G
L
-
F
G
V
E
L
F
V
C
G
---------
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
-
T
L
I
-
S
Q
D
L
S
E
F
A
L
H
V
R
A
F
L
G
L
P
--
43
HHSearch
44.26
18%
-67
- C2 -
2DWC
1
PURT_PYRHO
A:
[72-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
--------------------------
L
F
E
F
E
K
D
G
Y
F
-
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
L
V
K
E
A
K
V
P
T
S
R
Y
M
--
Y
A
--
T
T
L
D
E
L
Y
E
A
C
E
K
-
I
-
G
Y
P
C
H
T
K
A
I
M
S
------
Y
F
V
K
---
G
P
E
D
I
P
K
A
W
E
E
---------------------
E
K
I
I
V
E
E
H
I
D
---
F
D
V
E
V
T
-
E
L
A
V
R
H
F
D
E
---
N
---
G
E
I
V
T
T
F
P
K
P
V
G
H
Y
Q
I
D
G
D
-----------------------------------------
Y
H
A
S
W
Q
P
--------------------
A
E
I
S
-
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
-----
G
L
G
-
I
-
F
G
V
E
M
F
V
K
G
---------
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
S
H
P
P
G
F
S
E
F
A
L
H
L
R
A
V
L
G
L
P
--
45
HHSearch
44.06
16%
-73
- C2 -
2XCL
2
PUR2_BACSU
A:
[50-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
-------------------------
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
-
K
K
Y
D
I
P
T
A
E
Y
E
--
T
F
--
T
S
F
D
E
A
K
A
Y
V
Q
E
-
K
-
G
A
P
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
---
T
E
E
E
A
I
A
C
L
H
D
F
----
L
------
E
DEKFGD
A
S
A
S
V
V
I
E
E
Y
L
S
---
G
----
E
-
E
F
S
L
M
--
A
F
VK-
G
---
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
-----------
K
G
P
N
T
------------------------
G
G
M
G
A
Y
S
P
-------------------
V
P
Q
I
S
E
E
T
V
R
H
A
V
E
T
I
V
K
P
A
A
K
A
M
V
Q
E
GRS
F
T
G
-
V
-
L
Y
A
G
L
M
L
T
E
---------
N
G
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
-
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
D
D
K
E
--
38
HHSearch
43.85
16%
-57
- C2 -
3VPB
5
ARGX_SULTO
A:
[67-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
A
G
V
H
-
T
I
N
S
S
D
V
I
N
V
C
G
D
K
I
L
T
Y
S
K
L
-
Y
R
E
G
I
P
I
P
D
S
I
--
I
A
--
L
S
A
E
A
A
L
K
A
Y
E
Q
-
R
-
G
F
P
L
I
D
K
P
P
I
G
S
W
G
R
L
V
S
L
I
R
D
---
V
F
E
G
K
T
I
I
E
H
R
E
L
MG
N
------
S
------
A
L
K
A
H
I
V
Q
E
Y
I
Q
---
Y
KG--
R
-
D
I
R
C
I
--
A
I
---
G
---
E
E
L
L
G
C
Y
A
R
N
I
P
P
--
N
E
----------------
W
R
-------------------------------------------
A
N
V
A
L
G
G
T
P
S
N
---
I
E
V
D
E
K
L
K
E
T
V
V
K
A
V
S
I
V
H
-----
G
-
E
-
F
-
V
S
I
D
I
L
E
H
P
N
--------
K
G
Y
V
V
N
E
L
N
D
V
P
E
F
K
G
F
M
-
V
---
A
T
N
I
N
V
A
Q
K
L
V
E
Y
I
K
E
N
Y
--
51
HHSearch
43.26
15%
-61
- C2 -
3OUZ
10
?
A:
[68-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
I
I
A
A
A
E
I
A
E
A
D
A
I
F
P
G
Y
G
F
L
S
-
E
N
Q
N
-----------------------
F
V
E
I
C
A
K
H
N
I
K
F
I
G
P
S
V
E
A
M
N
L
M
S
D
K
S
K
A
K
Q
V
M
-
Q
R
A
G
V
P
V
I
P
G
S
--
D
G
AL
A
G
A
E
A
A
K
K
L
A
K
E
-
I
-
G
Y
P
V
I
L
K
A
A
A
G
G
G
G
R
G
M
R
V
V
E
---
N
E
K
D
L
E
K
A
Y
W
S
A
----
E
S
E
A
M
T
A
F
------
G
D
G
T
M
Y
M
E
K
Y
I
Q
---
N
P
---
R
-
H
I
E
V
Q
--
V
I
---
G
D
SF
G
N
V
I
H
V
G
E
R
D
C
S
M
--
Q
------------
R
---
R
H
--------------------------------------------
Q
K
L
I
E
E
S
P
A
I
L
L
D
-
E
K
T
R
T
R
L
H
E
T
A
I
K
A
A
K
A
I
G
-----
Y
-
E
G
A
-
G
T
F
E
F
L
V
D
K
N
--------
L
D
F
Y
F
I
E
M
N
T
R
L
Q
V
E
H
C
V
-
S
E
-
M
V
S
G
I
D
I
I
E
Q
M
I
K
V
A
E
G
Y
A
--
49
HHSearch
43.25
18%
-68
- C2 -
1ULZ
-
?
A:
[63-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
I
I
N
L
A
L
E
V
G
A
D
A
I
H
P
G
Y
G
F
L
A
E
N
A
E
------------------------
F
A
K
M
C
E
E
A
G
I
T
F
I
G
P
H
W
K
V
I
E
L
M
G
D
K
A
R
S
K
E
V
M
-
K
K
A
G
V
P
V
V
P
G
S
DG
V
L
--
K
S
L
E
E
A
K
A
L
A
R
E
-
I
-
G
Y
P
V
L
L
K
A
T
A
G
G
G
G
R
G
I
R
I
C
R
---
N
E
E
E
L
V
K
N
Y
E
Q
A
----
S
------
R
E
A
E
K
A
F
G
R
G
D
L
L
L
E
K
F
I
E
---
N
----
P
K
H
I
E
Y
Q
--
V
L
G
D
K
H
---
G
N
V
I
H
L
G
E
R
D
C
S
I
--
Q
----------------
R
R
N
-------------------------------------------
Q
K
L
V
E
I
A
P
S
L
I
L
T
-
P
E
K
R
E
Y
Y
G
N
I
V
T
K
A
A
K
E
I
G
-----
Y
-
Y
-
N
A
G
T
M
E
F
I
A
D
Q
E
--------
G
N
L
Y
F
I
E
M
N
T
R
I
Q
V
E
H
P
V
-
S
E
M
-
V
T
G
I
D
I
V
K
W
Q
I
K
I
A
A
G
E
P
--
58
Fugue
41.75
17%
-45
- C2 -
4IWX
7
RIMK_ECOLI
A:
[19-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
K
I
A
I
L
S
R
D
G
T
L
Y
S
C
K
R
L
R
E
A
----
A
I
Q
R
G
H
L
V
E
I
L
D
P
L
S
C
Y
M
N
I
N
P
A
A
S
S
I
H
Y
KG
R
K
L
P
H
F
D
A
V
I
P
R
I
G
T
A
I
T
F
Y
G
T
A
A
L
R
Q
F
E
----------------
M
-----
L
G
S
Y
P
L
N
E
S
V
A
I
-
A
R
A
R
--------
D
K
L
R
S
M
Q
L
L
-
A
R
Q
G
I
D
L
P
V
T
G
--
I
A
--
H
S
P
D
D
T
S
D
L
I
D
M
-
V
G
G
A
P
L
V
V
K
L
V
E
G
T
Q
G
I
G
V
V
L
A
E
T
---
R
Q
A
A
E
S
V
I
D
A
F
----
R
------
G
------
L
N
A
H
I
L
V
Q
E
Y
I
K
EAQ
G
----
C
-
D
I
R
C
L
--
V
V
---
G
---
D
E
V
V
A
A
I
E
R
R
A
K
-------------------------------------------------------------
E
G
D
F
R
S
N
L
H
R
G
G
A
A
S
V
A
S
---
I
T
P
Q
E
R
E
I
A
I
K
A
A
R
T
M
A
-----
L
-
D
-
V
-
A
G
V
D
I
L
R
A
N
---------
R
G
P
L
V
M
E
V
N
A
S
P
G
L
---
E
-
G
I
E
K
T
T
G
I
D
I
A
G
K
M
I
R
W
I
E
R
H
A
TT