@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1866: (2015-12-11 )
MTQLNSSFMIGKVEIPHRTVLAPMAGITNSAFRTIAKEFGAGLVVMEMISEKGLLYNNEKTLHMLHIDENEHPMSIQLFGGDAEGLKRAADFIQSNTKADIVDINMGCPVNKVVKNEAGAKWLRDPEKIYHIVKEVTSVLDIPLTVKMRTGWSDSSNAIENALAAESAGVSALAMHGRTREQMYTGTCDHETLGKVAKAVTSIPFIANGDIRTVHDAKFMIEEIGADAIMVGRGARSNPYIFTQINHFFETGEILPDLPFEKMLDVAEDHLTRLVNLKGETIAVREFRGLAPHYLRGKSGAAKIRGAVSRAETLAEVQELFAGLR
Atome Classification :
(20 SA)
.........10........20..-....--------..-----30-------.......-------.40..-.-....-..50...--.---------------------.-.-.------------------------------.--------60-------------------.-----------.-...-.---.---.---.70..----......80------------------------.-----------------------.----------------------...-...90......---..-100.....---------.---------.110.......120.......130.......140.--........150------..----.---.-...160.....---..170......-------.180--------------------.-------------------.--..----..--.----.----.----190.......200........210.......220.......230.....-..240.....--..250.......260.......270.......280.....-..290.......300......-.--310....-...320...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTQLNS
S
F
M
I
G
K
V
EIPHR
T
V
LAP-MAGI--------
T
N
-----
S
A
-------
F
R
T
I
A
K
E
-------FG-A
G
-
L
-
V
V
M
E
-
M
I
S
EKG
L
--
L
---------------------Y-N-N------------------------------E--------
K
--------------------
T
-----------
L
-
H
M
L
-
H
---I---D---ENEH
P
----
M
S
I
Q
L
FGG------------------------
D
-----------------------
A
----------------------
E
G
L
-
K
R
A
A
D
F
I
QSNT---KA-
D
I
V
D
I
NMG---------C---------P
V
N
K
V
V
KNEAGAKWLR
D
P
E
K
I
Y
H
I
V
K
E
V
T
S
VL--D--I
P
L
T
V
K
M
RTGW------SD----S---
S
-
N
A
I
E
N
A
L
A
A
E
S---AG
V
S
A
L
A
MHGR-------
T
R
----------------------
E
-------------------
Q
--
M
Y----TG--T----C----
D
----
H
E
T
L
G
K
V
A
K
A
V
T-SI
P
F
IANGD
I
R
T
V
H
D
A
K
F
M
I
E
E
IGA
D
A
I
M
VGRGARS-N
P
Y
I
F
T
Q
I
N
H
--
F
F
ETGEILPDL
P
F
E
K
M
L
D
V
A
E
D
H
L
T
R
L
V
NLKG
E
T
I
A
V
R
E
F-RGLAPHYLRGKSG
A
A
K
I
R
G
A
V
-
S
--
R
A
E
T
L
A
E
-
V
Q
E
L
F
AGLR-----
32
HHSearch
97.65
37%
-96
- C4 -
1VHN
4
?
A:
[5-304]
----------------
V
K
V
G
L
A
P
-
M
A
G
Y
--------
T
D
-----
S
A
-------
F
R
T
L
A
F
E
-------
W
G
-
A
D
-
F
-
A
F
S
E
-
M
V
S
A
K
G
F
--
L
---------------------
M
-
N
-
S
------------------------------
Q
--------
K
--------------------
T
-----------
E
-
E
L
L
-----
P
---
Q
---
P
H
E
R
N
----
V
A
V
Q
I
F
G
S
------------------------
E
-----------------------
P
----------------------
N
E
L
-
S
E
A
A
R
I
L
S
E
-----
K
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
--
G
K
F
S
V
K
T
R
L
G
W
------
E
K
--------
N
-
E
V
E
E
I
Y
R
I
L
V
E
---
E
G
V
D
E
V
F
I
H
T
R
-------
T
V
----------------------
V
-------------------
Q
--
S
F
----
T
G
--
R
----
A
----
E
----
W
K
A
L
S
V
L
E
K
----
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
--
F
L
R
S
G
K
-
Y
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
--
K
I
E
E
V
Q
I
-
L
K
E
M
F
Y
N
F
I
-----
1
PsiBlast_PDB
93.55
37%
-95
- C4 -
1VHN
4
?
A:
[9-301]
--------------------
L
A
P
-
M
A
G
Y
--------
T
D
-----
S
A
-------
F
R
T
L
A
F
E
-------
W
G
-
A
D
-
F
-
A
F
S
E
-
M
V
S
A
K
G
F
--
L
---------------------
M
-
N
-
S
------------------------------
Q
--------
K
--------------------
T
-----------
E
-
E
L
L
-
P
-------
Q
---
P
H
E
R
N
----
V
A
V
Q
I
F
G
S
------------------------
E
-----------------------
P
----------------------
N
E
L
-
S
E
A
A
R
I
L
S
E
K
Y
---
K
---
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
--
G
K
F
S
V
K
T
R
L
G
W
------
E
K
----
N
---
E
V
E
E
I
Y
R
I
L
V
E
E
-----
G
V
D
E
V
F
I
H
T
R
-------
T
V
----------------------
V
-------------------
Q
--
S
F
----
T
G
--
R
----
A
----
E
----
W
K
A
L
S
V
L
E
K
----
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
--
F
L
R
S
G
K
-
Y
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
M
-
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
-
M
--
K
I
E
E
V
Q
I
-
L
K
E
M
F
Y
N
F
I
-----
55
Fugue
92.93
34%
-92
- C4 -
1VHN
4
?
A:
[5-309]
----------------
V
K
V
G
L
A
P
M
A
-
G
Y
--------
T
D
-----
S
A
-------
F
R
T
L
A
F
E
-------
W
G
-
A
D
-
F
-
A
F
S
E
M
V
S
A
K
G
F
L
---------------------------
M
N
------------------------------
S
--------
Q
--------------------
K
-----------
T
-
E
E
L
-
L
---
P
---
Q
---
P
H
E
R
N
----
V
A
V
Q
I
F
G
S
------------------------
E
-----------------------
P
----------------------
N
E
L
-
S
E
A
A
R
I
L
S
E
K
-----
Y
-
K
W
I
D
L
N
A
G
---------
C
---------
P
V
R
K
V
V
K
E
G
A
G
G
A
L
L
K
D
L
R
H
F
R
Y
I
V
R
E
L
R
K
S
V
--
S
--
G
K
F
S
V
K
T
R
L
G
W
-------
E
----
K
---
N
-
E
V
E
E
I
Y
R
I
L
V
E
---
E
G
V
D
E
V
F
I
H
T
R
-------
T
V
----------------------
V
-------------------
Q
--
S
F
----
T
G
--
R
----
A
----
E
----
W
K
A
L
S
V
L
E
K
----
R
I
P
T
F
V
S
G
D
I
F
T
P
E
D
A
K
R
A
L
E
E
S
G
C
D
G
L
L
V
A
R
G
A
I
G
-
R
P
W
I
F
K
Q
I
K
D
--
F
L
R
S
G
K
-
Y
S
E
P
S
R
E
E
I
L
R
T
F
E
R
H
L
E
L
L
I
K
T
K
G
E
R
K
A
V
V
E
-
M
R
K
F
L
A
G
Y
T
K
D
L
K
G
A
R
R
F
R
E
K
V
M
K
IE
E
V
Q
I
L
K
E
M
F
Y
N
F
I
K
E
V
E
-----
33
HHSearch
82.90
23%
-105
- C4 -
3B0P
1
DUSAL_THET8
A:
[2-312]
--------------
L
D
P
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
-----
R
H
-------
F
R
F
L
V
R
Q
-------
V
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
-
G
-
N
------------------------------
R
--------
E
----------------------------------
R
L
L
-
A
---
F
---
R
---
P
E
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
-
A
E
A
A
R
I
G
E
A
-
F
---
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
--
V
P
V
T
V
K
M
R
L
G
L
------
E
G
----
K
ET
Y
R
-
G
L
A
Q
S
V
E
A
M
A
E
---
A
G
V
K
V
F
V
V
H
A
R
-------
S
A
----------------------
L
------------------------------IP
P
----
L
----
R
----
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
--
R
V
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
--
R
V
F
G
L
P
--
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
---
P
P
W
A
V
-
L
R
H
M
L
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
--
E
G
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
-----
57
Fugue
82.58
23%
-98
- C4 -
3B0P
1
DUSAL_THET8
A:
[2-318]
---
L
D
P
R
L
S
V
-----------
A
P
-
M
V
D
R
--------
T
D
-----
R
H
-------
F
R
F
L
V
R
Q
-------
V
S
-
L
G
V
R
-
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
-
G
-
N
------------------------------------------------------------
R
-----------
E
-
R
L
L
-
A
---
F
---
R
---
P
E
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
-
A
E
A
A
R
I
G
E
A
F
----
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
--
V
P
V
T
V
K
M
R
L
G
L
EGK---
E
T
----
Y
---
R
-
G
L
A
Q
S
V
E
A
M
A
E
---
A
G
V
K
V
F
V
V
H
A
R
-------
S
----------------------------------------------
A
L
----
I
P
--
P
----
L
----
R
----
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
R
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
RV
F
G
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
---
P
W
A
V
L
R
H
M
-
L
N
L
----
F
R
G
R
P
K
G
R
L
W
R
R
L
L
-
S
--
E
G
R
S
L
Q
A
-
L
D
R
A
L
R
L
M
E
E
E
VGE
56
Fugue
74.44
25%
-78
- C4 -
4BFA
6
DUSC_ECOLI
A:
[22-338]
--------------
A
S
M
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
-----
S
L
-------
V
R
E
L
L
T
E
V
N
DYD
L
C
I
T
-
E
F
-
V
-
R
V
V
D
-
Q
L
L
P
V
K
V
--
F
---------------------
H
-
R
-
I
------------------------------
C
--------
P
--------------------
E
-----------
L
-
Q
N
A
-
S
---
R
---
T
---
P
S
G
T
L
----
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
-
A
E
N
A
A
R
A
V
E
L
----
G
S
-
W
G
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
PA
H
--
L
P
V
S
V
K
V
R
L
G
W
------
D
S
----
G
---
E
-
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
----------------------
E
-------------------
Q
--
G
Y
----
R
A
--
E
H---
I
----
D
----
W
Q
A
I
G
D
I
R
Q
R
L
N
--
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
S
R
V
V
K
Y
------
N
E
--
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
I
-
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
-
R
--
V
L
N
N
S
P
D
-
I
A
R
A
I
Q
A
I
D
IEKL-
2
PsiBlast_PDB
73.31
30%
-101
- C4 -
3W9Z
1
DUSC_ECOLI
A:
[2-259]
-----------------
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
-----
S
L
-------
V
R
E
L
L
T
E
-------
V
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
-
P
-
V
---------------------------------------
K
--------------------
V
-----------
F
-
H
R
I
-
C
---
P
---
E
LQN
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
---
W
G
---
V
D
L
N
C
G
---------
C
----------------------
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
--
P
AH
L
P
V
S
V
K
V
R
L
G
W
------
D
S
----
G
---
E
-
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
----------------------
E
-------------------
Q
--
G
Y
----
R
A
--
E
H---
I
----
D
----
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-
S
R
V
V
K
--
Y
N
E
-----
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
-
T
R
L
E
H
V
A
R
I
K
Q
W
L
S
Y
L
-
R
K
E
Y
D
E
A
T
E
L
F
Q
H
V
R
V
S
P
D
I
A
-
R
--
A
I
Q
A
I
D
I
-
E
K
------------
3
PsiBlast_PDB
72.70
30%
-89
- C4 -
4BFA
5
DUSC_ECOLI
A:
[25-282]
-----------------
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
-----
S
L
-------
V
R
E
L
L
T
E
-------
V
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
-
P
--------------------------------
V
--------
K
--------------------
V
-----------
F
-
H
R
I
-
C
---
P
---
E
LQN
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
---
W
G
---
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
--
P
AH
L
P
V
S
V
K
V
R
L
G
W
------
D
S
----
G
---
E
-
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
----------------------
E
-------------------
Q
--
G
Y
----
R
A
--
E
H---
I
----
D
----
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-
S
R
V
V
K
--
Y
N
E
-----
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
-
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
-
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
-
V
--
R
V
L
N
N
S
P
-
D
I
A
R
A
I
Q
A
I
-----
7
PsiBlast_PDB
72.34
29%
-91
- C4 -
4YCP
2
DUSC_ECOLI
A:
[8-265]
-----------------
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
-----
S
L
-------
V
R
E
L
L
T
E
-------
V
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
-
P
--------------------------------
V
--------
K
--------------------
V
-----------
F
-
H
R
I
-
C
---
P
---
E
LQN
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
---
W
G
---
V
D
L
N
C
G
---------
A
---------
P
-------
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
--
P
AH
L
P
V
S
V
K
V
R
L
G
W
------
D
S
----
G
---
E
-
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
----------------------
E
-------------------
Q
--
G
Y
----
R
A
--
E
H---
I
----
D
----
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-
S
R
V
V
K
--
Y
N
E
-----
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
-
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
-
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
-
V
--
R
V
L
N
N
S
P
-
D
I
A
R
A
I
Q
A
I
-----
6
PsiBlast_PDB
71.92
29%
-92
- C4 -
4YCO
1
DUSC_ECOLI
A:
[8-265]
-----------------
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
-----
S
L
-------
V
R
E
L
L
T
E
-------
V
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
-
P
--------------------------------
V
--------
K
--------------------
V
-----------
F
-
H
R
I
-
C
---
P
---
E
LQN
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
---
W
G
---
V
D
L
N
C
G
---------
A
---------
P
S
----
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
--
P
AH
L
P
V
S
V
K
V
R
L
G
W
------
D
S
----
G
---
E
-
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
----------------------
E
-------------------
Q
--
G
Y
----
R
A
--
E
H---
I
----
D
----
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-
S
R
V
V
K
--
Y
N
E
-----
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
-
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
-
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
-
V
--
R
V
L
N
N
S
P
-
D
I
A
R
A
I
Q
A
I
-----
8
PsiBlast_PDB
69.70
29%
-88
- C4 -
4BF9
1
DUSC_ECOLI
A:
[25-282]
-----------------
R
V
L
L
A
P
-
M
E
G
V
--------
L
D
-----
S
L
-------
V
R
E
L
L
T
E
-------
V
N
D
Y
D
-
L
-
C
I
T
E
-
F
V
R
V
V
D
Q
--
L
---------------------
L
-
P
--------------------------------
V
--------
K
--------------------
V
-----------
F
-
H
R
I
-
C
---
P
---
E
LQN
A
S
R
T
P
S
G
T
L
V
R
V
Q
L
L
G
Q
------------------------
F
-----------------------
P
----------------------
Q
W
L
A
E
N
A
A
R
A
V
E
L
G
S
---
W
G
---
V
D
L
N
C
G
---------
C
---------
P
S
K
T
V
N
G
S
G
G
G
A
T
L
L
K
D
P
E
L
I
Y
Q
G
A
K
A
M
R
E
A
V
--
P
AH
L
P
V
S
V
K
V
R
L
G
W
------
D
S
----
G
---
E
-
K
K
F
E
I
A
D
A
V
Q
Q
---
A
G
A
T
E
L
V
V
H
G
R
-------
T
K
----------------------
E
-------------------
Q
--
G
Y
----
R
A
--
E
H---
I
----
D
----
W
Q
A
I
G
D
I
R
Q
R
L
--
N
I
P
V
I
A
N
G
E
I
W
D
W
Q
S
A
Q
Q
C
M
A
I
S
G
C
D
A
V
M
I
G
R
G
A
L
N
-
I
P
N
L
-
S
R
V
V
K
--
Y
N
E
-----
P
R
M
P
W
P
E
V
V
A
L
L
Q
K
Y
-
T
R
L
E
K
Q
G
D
T
G
L
Y
H
V
A
R
-
I
K
Q
W
L
S
Y
L
R
K
E
Y
D
E
A
T
E
L
F
Q
H
-
V
--
R
V
L
N
N
S
P
-
D
I
A
R
A
I
Q
A
I
-----
37
HHSearch
67.88
20%
-93
- C4 -
3HGJ
2
?
A:
[2-336]
-
A
L
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
A
M
S
P
-
M
C
Q
Y
SATLEGEV
T
D
-----
W
H
L
L
H
----
Y
P
T
R
A
-
L
-------
G
G
-
V
G
-
L
-
I
L
V
E
-
A
T
A
V
E
P
L
--
G
---------------------
R
-
I
-
S
------------------------------
P
--------
Y
--------------------
D
LGIWSEDH
L
P
G
L
-
K
E
L
A
R
R
--
I
---
R
---
E
A
G
A
V
----
P
G
I
Q
L
A
H
A
------------------------
G
RKAGTARPWEGGKPLGWRVVGPS
P
IPFDEGYPVPEPLD
E
A
G
M
E
R
I
L
Q
A
F
-
V
E
G
A
R
R
A
L
R
-
A
---
G
F
-
Q
V
I
E
L
H
M
A
---------
H
GY
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
PR
E
--
L
P
L
F
V
R
V
S
A
T
D
WGEGGW
S
L
--------
E
-
D
T
L
A
F
A
R
R
L
K
E
---
L
G
V
D
L
L
D
C
S
S
G
-------
G
V
----------------------
V
-------------------
L
--
R
V
RIPL
A
P
--
G
----
F
----
Q
----
V
P
F
A
D
A
V
R
K
R
V
--
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
-
D
P
Y
F
P
L
R
A
A
K
--
A
L
G
V
A
P
E
V
P
P
Q
Y
Q
R
G
F
------------------------------------------------------------------------
54
HHSearch
66.56
18%
-105
- C4 -
1GTE
2
DPYD_PIG
A:
[532-835]
----
D
I
S
V
E
M
A
G
L
K
F
I
N
P
F
G
L
A
S
-
A
A
P
T
--------
T
S
-----
S
S
-------
M
I
R
R
A
F
E
-------
A
G
-
W
G
-
F
-
A
L
T
K
-
T
F
S
L
D
K
D
I
V
T
---------------------
N
-
V
-
S
PR
I
V
R
G
TTSGPMYGPGQS
S
F
L
N
IELISEKT
A
--------
A
--------------------
Y
-----------
W
C
Q
S
V
-
T
E
--
L
K
A
-
D
---
F
P
D
N
I
----
V
I
A
S
I
M
C
S
Y-----------------------
N
-----------------------
K
----------------------
N
D
W
-
M
E
L
S
R
K
A
E
A
-
S
---
G
A
-
D
A
L
E
L
N
L
S
---------
C
---------
P
H
G
M
G
------
L
A
C
G
Q
D
P
E
L
V
R
N
I
C
R
W
V
R
Q
A
V
--
Q
--
I
P
F
F
A
K
L
T
P
N
V
------
T
D
-----------
I
V
S
I
A
R
A
A
K
E
---
G
G
A
D
G
V
T
A
T
N
T
-------
V
S
G
L
MGLKADGTPWPAVGAGKRT
T
Y
-------------------
G
--
G
V
----
S
G
--
T
----
A
----
I
R
P
I
A
L
R
A
V
T
T
I
A
R
A
L
P
-
G
F
P
I
L
A
T
G
G
I
D
S
A
E
S
G
L
Q
F
L
H
-
S
G
A
S
V
L
Q
V
C
S
A
V
Q
N
Q
D
F
T
V
I
Q
D
Y
C
T
--
G
L
K
A
L
L
Y
L
K
S
I
E
E
L
Q
G
W
D
G
Q
S
P
G
T
E
S
H
Q
K
G
K
P
V
P
R
I
A
E
L
M
-
G
K
K
L
P
N
F
G
P
Y
L
E
Q
R
K
K
I
I
A
E
E
-
K
--
M
R
L
K
E
Q
N
-
E
R
K
P
F
I
P
K
K
-----
10
PsiBlast_PDB
66.49
25%
-98
- C4 -
3B0V
1
DUSAL_THET8
C:
[26-261]
-----------------
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
-----
R
H
-------
F
R
F
L
V
R
Q
-------
V
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
-
G
-
N
------------------------------
R
--------
E
--------------------
R
-----------
L
---
L
-
A
---
F
---
R
---
P
E
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
-
A
E
A
A
R
-
I
G
E
A
F
---
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
--
V
P
V
T
V
K
M
R
L
G
L
------
E
G
----
K
---
E
-
T
Y
R
G
L
A
Q
S
V
E
A
MAE
A
G
V
K
V
F
V
V
H
A
R
SALLALS
T
K
----------------------
A
-------------------
N
--
R
E
----
I
P
--
P
----
L
----
R
----
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
R
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
--
R
V
F
G
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
L
R
H
M
L
-
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
-
L
--
Q
A
L
D
R
A
L
-
R
L
M
E
E
E
--------
4
PsiBlast_PDB
66.28
26%
-97
- C4 -
3B0P
1
DUSAL_THET8
A:
[5-240]
-----------------
R
L
S
V
A
P
-
M
V
D
R
--------
T
D
-----
R
H
-------
F
R
F
L
V
R
Q
-------
V
S
-
L
G
-
V
R
L
Y
T
E
-
M
T
V
D
Q
A
V
--
L
---------------------
R
-
G
-
N
------------------------------
R
--------
E
--------------------
R
-----------
L
---
L
-
A
---
F
---
R
---
P
E
E
H
P
----
I
A
L
Q
L
A
G
S
------------------------
D
-----------------------
P
----------------------
K
S
L
-
A
E
A
A
R
-
I
G
E
A
F
---
G
Y
-
D
E
I
N
L
N
L
G
---------
C
---------
P
S
E
K
A
Q
E
G
G
Y
G
A
C
L
L
L
D
L
A
R
V
R
E
I
L
K
A
M
G
E
A
V
--
R
--
V
P
V
T
V
K
M
R
L
G
L
------
E
G
----
K
---
E
-
T
Y
R
G
L
A
Q
S
V
E
A
M
A
E
A
G
V
K
V
F
V
V
H
A
R
SAL---------------------------------------------------------
I
P
--
P
----
L
----
R
----
H
D
W
V
H
R
L
K
G
D
F
P
-
Q
L
T
F
V
T
N
G
G
I
R
S
L
E
E
A
L
F
H
L
K
R
V
--
D
G
V
M
L
G
R
A
V
Y
E
-
D
P
F
V
L
E
E
A
D
R
--
R
V
F
G
L
P
R
R
P
S
R
L
E
V
A
R
R
M
R
A
Y
L
E
E
E
V
L
K
G
T
P
P
W
A
V
L
R
H
M
L
-
N
L
F
R
G
R
P
K
G
R
L
W
R
R
L
L
S
E
G
R
S
-
L
--
Q
A
L
D
R
A
L
-
R
L
M
E
E
E
V
G
E
-----
53
HHSearch
64.65
20%
-87
- C4 -
1EP3
2
PYRDB_LACLM
A:
[4-288]
--
N
N
R
L
S
V
K
L
P
G
L
D
L
K
N
P
I
I
P
A
S
-
G
C
F
G
--------
F
G
-----
E
E
-------
Y
A
K
Y
Y
D
L
-------
N
K
-
L
G
-
S
-
I
M
V
K
-
A
T
T
L
H
P
R
--
F
GNPTPR
V
A
E
T
AS
G
M
L
N
AIGLQ
N
-
P
-
G
------------------------------
L
--------
E
--------------------
V
I
----------
M
T
E
K
L
-
P
W
L
N
E
---
N
---
F
P
E
L
P
----
I
I
A
N
V
A
G
S
------------------------
E
-----------------------
E
----------------------
A
D
Y
-
V
A
V
C
A
K
I
G
D
A
A
---
N
V
-
K
A
I
E
L
N
I
S
---------
C
---------
P
N
V
K
----
H
G
G
Q
A
F
G
T
D
P
E
V
A
A
A
L
V
K
A
C
K
A
V
S
--
K
--
V
P
L
Y
V
K
L
S
P
N
V
------
T
D
-----------
I
V
P
I
A
K
A
V
E
A
---
A
G
A
D
G
L
T
M
I
N
T
-------
L
M
----------------------
G
V
R
F
D
LKTRQPILANI
T
---
G
--
G
L
----
S
G
--
P
AI
K
P
V
----
A
----
L
K
L
I
H
Q
V
A
Q
D
V
--
D
I
P
I
I
G
M
G
G
V
A
N
A
Q
D
V
L
E
M
Y
M
-
A
G
A
S
A
V
A
V
G
T
A
N
F
A
-
D
P
F
V
C
P
K
I
I
D
--
K
L
P
E
L
M
D
Q
Y
R
I
E
S
L
E
S
L
I
Q
E
V
K
E
G
K
K
--------------------------------------------------------------
36
HHSearch
64.36
20%
-89
- C4 -
3KRU
2
?
A:
[2-325]
-
S
I
L
H
M
P
L
K
I
K
D
I
T
I
K
N
R
I
M
M
S
P
-
M
C
M
Y
--------
S
A
STDG-
M
P
N
D
W
H
I
V
H
Y
A
T
R
A
-
I
-------
G
G
-
V
G
-
L
-
I
M
Q
E
-
A
T
A
V
E
S
R
--
G
---------------------
R
-
I
-
T
------------------------------
D
--------
H
DLGIWN
D
E
------------
Q
V
K
E
--------
L
-
K
K
I
V
D
I
--
C
---
K
---
A
N
G
A
V
----
M
G
I
Q
L
A
H
A
GRKCNISYEDVVGPSPIKAGDRYK
L
-----------------------
P
RELS
V
E
E
I
K
S
I
V
----------
K
A
F
-
G
E
A
A
K
R
A
N
L
-
A
---
G
Y
-
D
V
V
E
I
H
A
A
HGY
L
I
H
E
F
L
S
---------
P
L
S
N
K
R
K
D
E
Y
G
N
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
PE
N
--
K
P
I
F
V
R
V
S
A
D
D
------
Y
M
EGGI
N
I
--
D
-
M
M
V
E
Y
I
N
M
I
K
----
D
K
V
D
L
I
D
V
S
S
G
-------
G
L
----------------------
L
-------------------
N
VD
I
N
----
L
Y
P-
G
----
Y
----
Q
----
V
K
Y
A
E
T
I
K
K
R
C
--
N
I
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
R
A
D
L
V
A
L
G
R
E
L
L
R
-
N
P
Y
W
V
L
H
T
Y
T
--
S
K
E
D
W
P
K
Q
Y
E
R
A
F
K
--------------------------------------------------------------------------
48
HHSearch
62.89
14%
-98
- C4 -
2E6F
7
PYRD_TRYCC
A:
[3-292]
----
C
L
K
L
N
L
L
D
H
V
F
A
N
P
F
M
N
A
A
-
G
V
L
C
--------
S
T
-----
E
E
D
------
L
R
C
M
T
-
A
-------
S
S
-
S
G
-
A
-
L
V
S
K
-
S
C
T
S
A
P
R
--
D
---------------------
G
N
P
-
E
------------------------------
P
--------
R
Y
M
A
F
PL
G
S
I
N
SMGLPNLG
F
D
F
-----------
Y
L
K
Y
A
-
S
D--
L
---
H
D--
Y
S
K
K
P
----
L
F
L
S
I
S
G
L
------------------------
S
-----------------------
V
----------------------
E
E
N
-
V
A
M
V
R
R
L
A
P
-
V
A
Q
E
K
G
-
V
L
L
E
L
N
L
S
---------
C
---------
P
N
V
P
G
-----
K
P
Q
V
A
Y
D
F
E
A
M
R
T
Y
L
Q
Q
V
S
L
A
Y
--
G
--
L
P
F
G
V
K
M
P
P
Y
F
------
D
I
--------
A
-
H
F
D
T
A
A
A
V
L
N
E
F
--
P
L
V
K
F
V
T
C
V
N
S
-------
V
G
----------------------
N
G
L
V
I
D
AESESVVIKPKQG
F
G
--
G
L
----
G
G
--
K
----
Y
I
L
P
T
A
----
L
A
N
V
N
A
F
Y
R
R
C
P
-
D
K
L
V
F
G
C
G
G
V
Y
S
G
E
D
A
F
L
H
I
L
-
A
G
A
S
M
V
Q
V
G
T
A
L
Q
E
E
G
P
G
I
F
T
R
L
E
D
--
E
L
L
E
I
M
A
R
K
G
Y
R
T
L
E
E
F
R
G
R
V
K
T
I
----------------------------------------------------------------
35
HHSearch
62.26
19%
-90
- C4 -
3GR7
3
NAMA_GEOKA
A:
[2-326]
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
V
M
S
P
-
M
C
M
Y
--------
S
C
DTKDG
A
V
R
T
W
H
K
I
H
Y
P
A
R
A
-
V
-------
G
Q
-
V
G
-
L
-
I
I
V
E
-
A
T
G
V
T
P
Q
--
G
---------------------
R
-
I
-
S
------------------------------
E
RDLGIWSD
D
--------------------
H
I
A
G
--------
L
-
R
E
L
V
G
L
--
V
---
K
---
E
H
G
A
A
----
I
G
I
Q
L
A
H
A
GRKSQVP
G
E
I
I
A
PSAVPFDDSSP-
T
-----------------------
P
KEMT
K
A
D
I
E
E
T
V
----------
Q
A
F
-
Q
N
G
A
R
R
A
K
E
-
A
---
G
F
-
D
V
I
E
I
H
A
A
HGY
L
I
N
E
F
L
S
---------
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
W
--
D
--
G
P
L
F
V
R
I
S
A
S
D
------
Y
H
PDGL
T
A--
K
-
D
Y
V
P
Y
A
K
R
M
K
E
---
Q
G
V
D
L
V
D
V
S
S
G
-------
A
I
----------------------
V
-------------------
P
A
R
M
N
----
V
Y
P-
G
----
Y
----
Q
----
V
P
F
A
E
L
I
R
R
E
A
--
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
-
N
P
Y
W
P
Y
A
A
A
R
--
E
L
G
A
K
I
S
A
P
V
Q
Y
E
R
G
W
R
F
----------------------------------------------------------------------
49
HHSearch
60.58
17%
-102
- C4 -
1JUB
6
PYRDA_LACLM
A:
[2-289]
-----
L
N
T
T
F
A
N
A
K
F
A
N
P
F
M
N
A
S
-
G
V
H
C
--------
M
T
-----
I
E
-------
D
L
E
E
L
K
A
-------
S
Q
-
A
G
-
A
-
Y
I
T
K
-
S
S
T
L
E
K
R
--
E
---------------------
G
N
P
-
L
------------------------------
P
--------
R
Y
V
D
L
EL
G
S
I
N
SMGLPNLG
F
D
Y
Y
----------
L
-
D
Y
V
-
L
K
--
N
Q
K
E
N
---
A
Q
E
G
P
----
I
F
F
S
I
A
G
M
------------------------
S
-----------------------
A
----------------------
A
E
N
-
I
A
M
L
K
K
I
Q
E
-
S
---
D
F
S
G
I
T
E
L
N
L
S
---------
C
---------
P
N
V
P
G
E
-----
P
Q
L
A
Y
D
F
E
A
T
E
K
L
L
K
E
V
F
T
F
F
--
T
--
K
P
L
G
V
K
L
P
P
Y
F
------
D
L
--------
V
-
H
F
D
I
M
A
E
I
L
N
Q
---
F
P
L
T
Y
V
N
S
V
N
S
-------
I
G
N
G
L
F
I
DPEAESVVIKPKDG---
F
-------------------
G
--
G
I
----
G
G
--
A
YI
K
P
T
----
A
----
L
A
N
V
R
A
F
Y
T
R
L
K
P
E
I
Q
I
I
G
T
G
G
I
E
T
G
Q
D
A
F
E
H
L
L
-
C
G
A
T
M
L
Q
I
G
T
A
L
H
K
E
G
P
A
I
F
D
R
I
I
K
--
E
L
E
E
I
M
N
Q
K
G
Y
Q
S
I
A
D
F
H
G
K
L
K
S
L
----------------------------------------------------------------