@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1878: (2015-12-11 )
MKKLTKGSHIRVLSPSSSIERLGGFEANLLAKEVLEKLGFQVSFSKHYLENDILYSASIASRVEDLHEAFADPSVDAILATIGGFNSNELLPYLDYDLISKNPKIICGYSDSTAFLNAIFAKAKIQTYMGPAYSSFKMKEGQPYQTQAWLTAMTENHYELWPSEEWSSDPWYDPSKPRQFFPTEWKIYNHGKASGTIIGGNLSTFGLLRGTPYAPKIERYVLLIEEAEESNFYEFDRNLAAILQAYPHPQAILMGRFPKECGMTPQVFEYILSKHAIFKEIPVIYDMDFAHTQPLLTVTIGAELSVDTTTLSLSIKE
Atome Classification :
(23 SA)
.........10........20..--......30........40.---.......50........60........70........80........90........100.......110.......120.......130.-......140--....---...------150.-..---..---..160---.......--170.-..-------..--.---...--180.......190........200.......210.....-..220....---.-..230.....--..240....--.--....250......--.--260.......270.......280.......290.......300.......310.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKLTKGS
H
I
R
V
LSPSS
S
I
E
R
LG--GF
E
A
N
L
L
A
K
E
V
L
E
KLG
F
Q
V
---
S
F
S
K
H
Y
LENDI
L
Y
S
A
S
I
A
S
R
V
E
D
L
H
E
A
FADP
S
V
D
A
I
L
A
T
IGGFNSNELLPYL
D
Y
D
L
ISKNP
K
I
I
C
GYSD
S
T
A
F
L
N
A
I
F
A
K
A
K
I
Q
T
YMGPAY-SSFKMKEGQ--PY
Q
T
---
Q
A
W
------
L
T
A
M-TE---NH---YELWP---SEEWSSD--P--W-YD-------PS--K---PRQ--FFPTE
W
K
I
Y
NH-GKAS
G
T
I
IGGNL
S
T
F
GLLRGTPYAPK
I
-
E
R
Y
V
L
L
I
EE---A-EES
N
F
Y
E
F
D
R
--
N
L
A
--
A
I
L
Q
--A--YPH
P
Q
A
I
L
MGR
F
P
--
K
--ECGM
T
P
Q
V
F
E
Y
I
L
S
K
H
A
I
F
K
EI
P
V
I
Y
DMDFAHTQ
P
L
L
T
V
T
IG
A
E
L
S
V
D
T
T
T
L
S
L
S
IKE
2
PsiBlast_PDB
98.67
43%
-105
- C4 -
4E5S
1
?
A:
[8-326]
--
K
L
K
K
G
D
E
I
R
V
I
S
P
S
C
S
L
S
-
I
V
--
S
T
E
N
R
R
L
A
V
K
R
L
T
E
L
G
F
H
V
---
T
F
S
T
H
A
E
E
I
D
R
F
A
S
S
S
I
S
S
R
V
Q
D
L
H
E
A
F
R
D
P
N
V
K
A
I
L
T
T
L
G
G
Y
N
S
N
G
L
L
K
Y
L
D
Y
D
L
I
R
E
N
P
K
F
F
C
G
Y
S
D
I
T
A
L
N
N
A
I
Y
T
K
T
G
L
V
T
Y
S
G
P
H
F
-
S
S
F
G
M
E
K
G
L
--
E
Y
T
T
---
D
Y
F
------
L
Q
C
L
-
T
S
---
N
K
P--
I
E
V
L
P
---
S
E
T
W
S
D
D
--
S
--
W
-
Y
I
-------
D
Q
--
E
---
N
R
K
--
F
I
K
N
E
G
Y
V
S
I
H
E
G
E
A
T
G
D
I
I
G
G
N
M
S
T
L
N
L
L
Q
G
T
S
Y
M
P
N
L
-
K
D
K
I
L
F
L
E
E
D
SL
T
-
G
T
S
T
L
K
T
F
D
R
--
Y
L
H
--
S
L
M
Q
--
Q
QN
F
K
H
V
K
G
I
V
I
G
K
M
Q
--
K
--
G
A
E
C
T
I
E
D
I
Q
E
M
I
A
S
K
P
E
L
A
H
I
P
I
I
A
N
A
S
F
G
H
T
T
P
I
F
T
F
P
I
G
G
R
A
T
I
I
S
S
K
E
K
T
S
I
T
I
1
PsiBlast_PDB
96.76
41%
-104
- C4 -
4INJ
3
?
A:
[8-316]
--
K
L
K
Q
G
D
E
I
R
I
I
A
P
S
R
S
I
G
I
M
A
--
D
N
Q
V
E
I
-
A
V
N
R
L
T
D
M
G
F
K
V
---
T
F
G
E
H
V
A
E
M
D
C
M
M
S
S
S
I
R
S
R
V
A
D
I
H
E
A
F
N
D
S
S
V
K
A
I
L
T
V
I
G
G
F
N
S
N
Q
L
L
P
Y
L
D
Y
D
L
I
S
E
N
P
K
I
L
C
G
F
A
D
I
T
A
L
A
T
A
I
Y
T
Q
T
E
L
I
T
Y
S
G
A
H
F
-
S
S
F
S
M
E
K
G
L
--
D
Y
V
M
---
E
S
F
------
S
D
C
L
-
L
Q
---
K
E
P--
F
A
L
K
E
---
S
A
T
W
S
D
D
--
E
--
W
-
Y
L
-------
D
Q
--
E
---
N
R
N
--
F
I
P
N
E
G
L
V
V
M
Q
P
G
V
A
E
G
I
I
I
G
G
N
L
C
T
L
N
L
L
Q
G
T
E
Y
M
P
N
L
-
A
G
T
I
L
F
I
E
D
---
D
-
F
M
T
I
P
E
T
F
D
R
--
D
L
E
--
S
L
L
S
QP
G
--
A
D
E
I
E
G
M
V
I
G
R
F
Q
--
Q
--
K
T
A
M
T
A
E
K
L
A
Y
I
I
E
T
K
T
A
L
Q
K
I
P
V
I
S
G
A
D
F
G
H
T
Q
P
I
A
T
F
P
I
G
G
T
A
R
I
D
T
N
Q
T
D
K
I
Q
I
I
3
PsiBlast_PDB
95.49
41%
-105
- C4 -
4H1H
2
?
A:
[8-316]
--
K
L
K
Q
G
D
E
I
R
I
I
A
P
S
R
S
I
G
I
M
A
--
D
N
Q
V
E
I
-
A
V
N
R
L
T
D
M
G
F
K
V
---
T
F
G
E
H
V
A
E
M
D
C
M
M
S
S
S
I
R
S
R
V
A
D
I
H
E
A
F
N
D
S
S
V
K
A
I
L
T
V
I
G
G
F
N
S
N
Q
L
L
P
Y
L
D
Y
D
L
I
S
E
N
P
K
I
L
C
G
F
S
D
I
T
A
L
A
T
A
I
Y
T
Q
T
E
L
I
T
Y
S
G
A
H
F
-
S
S
F
S
M
E
K
G
L
--
D
Y
V
M
---
E
S
F
------
S
D
C
L
-
L
Q
---
K
E
P--
F
A
L
K
E
---
S
A
T
W
S
D
D
--
E
--
W
-
Y
L
-------
D
Q
--
E
---
N
R
N
--
F
I
P
N
E
G
L
V
V
M
Q
P
G
V
A
E
G
I
I
I
G
G
N
L
C
T
L
N
L
L
Q
G
T
E
Y
M
P
N
L
-
A
G
T
I
L
F
I
E
D
---
D
-
F
M
T
I
P
E
T
F
D
R
--
D
L
E
--
S
L
L
S
QP
G
--
A
D
E
I
E
G
M
V
I
G
R
F
Q
--
Q
--
K
T
A
M
T
A
E
K
L
A
Y
I
I
E
T
K
T
A
L
Q
K
I
P
V
I
S
G
A
D
F
G
H
T
Q
P
I
A
T
F
P
I
G
G
T
A
R
I
D
T
N
Q
T
D
K
I
Q
I
I
21
PsiBlast_CBE
94.63
41%
-101
- C4 -
4INJ
6
?
B:
[8-316]
--
K
L
K
Q
G
D
E
I
R
I
I
A
P
S
R
S
I
G
I
M
A
--
D
N
Q
V
E
I
-
A
V
N
R
L
T
D
M
G
F
K
V
---
T
F
G
E
H
V
A
E
M
D
C
M
M
S
S
S
I
R
S
R
V
A
D
I
H
E
A
F
N
D
S
S
V
K
A
I
L
T
V
I
G
G
F
N
S
N
Q
L
L
P
Y
L
D
Y
D
L
I
S
E
N
P
K
I
L
C
G
F
A
D
I
T
A
L
A
T
A
I
Y
T
Q
T
E
L
I
T
Y
S
G
A
H
F
-
S
S
F
S
M
E
K
G
L
--
D
Y
V
M
---
E
S
F
------
S
D
C
L
-
L
Q
---
K
E
P--
F
A
L
K
E
---
S
A
T
W
S
D
D
--
E
--
W
-
Y
L
-------
D
Q
--
E
---
N
R
N
--
F
I
P
N
E
G
L
V
V
M
Q
P
G
V
A
E
G
I
I
I
G
G
N
L
C
T
L
N
L
L
Q
G
T
E
Y
M
P
N
L
-
A
G
T
I
L
F
I
E
D
---
D
-
F
M
T
I
P
E
T
F
D
R
--
D
L
E
--
S
L
L
S
QP
G
--
A
D
E
I
E
G
M
V
I
G
R
F
Q
--
Q
--
K
T
A
M
T
A
E
K
L
A
Y
I
I
E
T
K
T
A
L
Q
K
I
P
V
I
S
G
A
D
F
G
H
T
Q
P
I
A
T
F
P
I
G
G
T
A
R
I
D
T
N
Q
T
D
K
I
Q
I
I
23
PsiBlast_CBE
86.82
32%
-91
- C4 -
3U1B
1
?
B:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
A
L
P
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
R
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
24
PsiBlast_CBE
86.07
32%
-89
- C4 -
3T5M
1
?
B:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
8
PsiBlast_PDB
85.92
31%
-89
- C4 -
4MJX
3
?
A:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
A
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
7
PsiBlast_PDB
85.92
31%
-89
- C4 -
4JVO
1
?
A:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
A
L
P
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
A
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
5
PsiBlast_PDB
85.78
32%
-89
- C4 -
3U1B
1
?
A:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
R
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
15
PsiBlast_PDB
85.77
31%
-87
- C4 -
4MI1
2
?
A:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
A
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
22
PsiBlast_CBE
85.47
32%
-89
- C4 -
3TYX
1
?
B:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
--
S
IN
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
44
HHSearch
85.09
31%
-95
* C4 *
3TLA
1
MCCF_ECOLX
A:
[37-364]
A
A
P
L
A
V
G
D
T
I
G
F
F
S
S
S
A
P
A
T
V
T
A
--
K
-
N
R
F
F
R
G
V
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
-
I
P
S
F
G
E
H
P
P
L
V
D
I
T
Y
---
E
S
F
------
I
K
I
L
-
T
R
KQS
G
I
---
Y
T
Y
T
L
---
P
E
K
W
S
D
E
--
S
IN
W
-
N
E
-------
N
K
--
I
---
L
R
P
K
K
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
M
P
E
I
R
N
G
D
I
L
F
I
E
D
---
S
R
K
S
I
--
A
T
V
E
R
--
L
F
S
--
M
L
K
L
--
N
RV
F
D
K
V
S
A
I
I
L
G
K
H
E
LF
D
---
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E
6
PsiBlast_PDB
85.00
32%
-92
- C4 -
3T5M
2
?
A:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
4
PsiBlast_PDB
83.93
32%
-87
- C4 -
3TYX
1
?
A:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
--
S
IN
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
26
PsiBlast_CBE
83.90
31%
-88
- C4 -
4JVO
2
?
B:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
ALP
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
A
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
25
PsiBlast_CBE
83.34
31%
-88
- C4 -
4MJX
1
?
B:
[8-332]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
A
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
K
Y
F
---
L
E
T
L
-
L
H
---
D
Q
A
L
P
Y
N
I
K
Q
---
P
L
F
W
S
D
E
FI
N
--
W
-
E
E
-------
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
A
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
9
PsiBlast_PDB
82.28
32%
-79
- C4 -
3SR3
-
?
A:
[5-329]
-
K
S
L
K
Y
G
D
T
I
G
I
Y
S
P
S
S
P
V
T
Y
T
S
P
K
R
F
E
R
---
A
K
S
Y
L
L
Q
K
G
F
H
I
L
E
G
S
L
T
G
R
Y
---
D
Y
Y
R
S
G
S
I
Q
E
R
A
K
E
L
N
A
L
I
R
N
P
N
V
S
C
I
M
S
T
I
G
G
M
N
S
N
S
L
L
P
Y
I
D
Y
D
A
F
Q
N
N
P
K
I
M
I
G
Y
S
D
A
T
A
L
L
L
G
I
Y
A
K
T
G
I
P
T
F
Y
G
P
A
L
-
V
P
-
S
F
G
E
F
E
--
P
F
V
D
---
D
T
Y
------
K
Y
F
L
E
T
L
---
L
H
---
D
Q
A
L
P
---
Y
N
I
K
Q
P
L
--
F
--
W
-
S
D
E
F
I
N
AEE
K
T
--
K
---
E
K
E
--
L
R
P
N
N
W
I
S
V
T
N
-
G
Q
A
T
G
R
V
I
G
G
N
L
N
T
I
Q
G
I
W
G
S
P
Y
M
P
C
I
-
Q
E
G
D
I
L
F
I
E
---
D
-
S
S
K
D
A
A
T
I
E
R
--
S
F
S
F
L
K
I
N
G
--
V
--
F
D
K
V
S
G
I
I
L
G
K
H
E
--
Q
FD
D
C
G
T
N
R
K
P
Y
E
-
I
L
L
E
V
L
Q
N
Q
R
I
P
L
L
A
D
F
D
C
C
H
T
H
P
M
I
T
M
P
I
G
V
Q
V
K
M
D
A
T
N
K
T
I
H
I
L
E
13
PsiBlast_PDB
79.97
31%
-102
- C4 -
3TLB
1
MCCF_ECOLX
A:
[68-364]
----------------------------------
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
I
P
S
F
--
G
E
H
P
--
P
L
V
D
I
T
Y
E
S
F
------
I
K
I
L
-
T
R
---
K
Q
---
A
G
I
Y
T
Y
T
L
P
E
K
W
S
D
E
--
S
IN
W
-
N
E
-------
N
K
IL
R
---
P
K
K
--
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
M
P
E
I
-
R
N
G
D
I
L
F
I
E
---
D
-
S
R
K
S
I
A
T
V
E
R
L
F
S
M
L
--
K
L
N
R
--
V
--
F
D
K
V
S
A
I
I
L
G
K
H
E
--
L
F-
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E
28
PsiBlast_CBE
79.48
31%
-103
- C4 -
3TLB
1
MCCF_ECOLX
B:
[68-364]
----------------------------------
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
I
P
S
F
--
G
E
H
P
--
P
L
V
D
ITY
E
S
F
------
I
K
I
L
-
T
R
---
K
Q
---
A
G
I
Y
T
YTL
P
E
K
W
S
D
E
--
S
IN
W
-
N
E
-------
N
K
IL
R
---
P
K
K
--
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
M
P
E
I
-
R
N
G
D
I
L
F
I
E
---
D
-
S
R
K
S
I
A
T
V
E
R
LF
S
M
L
--
K
L
N
R
--
V
--
F
D
K
V
S
A
I
I
L
G
K
H
E
--
L
F-
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E
19
PsiBlast_PDB
78.70
31%
-97
- C4 -
3TLZ
4
MCCF_ECOLX
A:
[68-364]
----------------------------------
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
S
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
I
P
S
F
--
G
E
H
P
--
P
L
V
D
---
I
T
Y
E
S
F
I
K
I
L
T
R
K
-
Q
S
---
G
I
---
Y
T
Y
T
L
---
P
E
K
W
S
D
E
--
S
--
I
N
F
N
-------
E
N
--
K
ILR
P
K
K
--
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
M
P
E
I
-
R
N
G
D
I
L
F
I
E
---
D
-
S
R
K
S
I
A
T
V
E
R
L
F
S
M
L
--
K
L
N
R
--
V
--
F
D
K
V
S
A
I
I
L
G
K
H
E
--
L
F-
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E
29
PsiBlast_CBE
77.47
31%
-98
- C4 -
3TLY
2
MCCF_ECOLX
B:
[68-364]
----------------------------------
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
I
P
S
F
--
G
E
H
P
--
P
L
V
D
---
I
T
Y
ESFIKI
L
T
R
K
-
Q
S
---
G
I
---
Y
T
Y
T
L
---
P
E
K
W
S
D
E
--
S
IN
W
-
N
E
-------
N
K
IL
R
---
P
K
K
--
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
A
T
L
T
G
I
W
G
S
E
W
M
P
E
I
-
R
N
G
D
I
L
F
I
E
---
D
-
S
R
A
S
I
A
T
V
E
R
LF
S
M
L
--
K
L
N
R
--
V
--
F
D
K
V
S
A
I
I
L
G
K
H
E
--
L
F-
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E
18
PsiBlast_PDB
77.28
31%
-97
- C4 -
4IIY
9
MCCF_ECOLX
A:
[68-364]
----------------------------------
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
I
P
S
F
--
G
E
H
P
--
P
L
V
D
---
I
T
Y
E
S
F
I
K
I
L
T
R
K
-
Q
S
---
G
I
---
Y
T
Y
T
L
---
P
E
K
W
S
D
E
--
S
IN
W
-
N
E
-------
N
K
IL
R
---
P
K
K
--
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
N
T
L
T
G
I
W
G
S
E
W
M
P
E
I
-
R
N
G
D
I
L
F
I
E
---
D
-
S
R
K
S
I
A
T
V
E
R
L
F
S
M
L
--
K
L
N
R
--
V
--
F
D
K
V
S
A
I
I
L
G
K
H
E
--
L
F-
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E
14
PsiBlast_PDB
77.19
31%
-98
- C4 -
3TLY
4
MCCF_ECOLX
A:
[68-364]
----------------------------------
E
F
L
Q
R
K
G
F
K
L
---
V
S
G
K
L
T
G
K
T
D
F
Y
R
S
G
T
I
K
E
R
A
Q
E
F
N
E
L
V
Y
N
P
D
I
T
C
I
M
S
T
I
G
G
D
N
S
N
S
L
L
P
F
L
D
Y
D
A
I
I
A
N
P
K
I
I
I
G
Y
A
D
T
T
A
L
L
A
G
I
Y
A
K
T
G
L
I
T
F
Y
G
P
A
L
I
P
S
F
--
G
E
H
P
--
P
L
V
D
---
I
T
Y
E
S
F
I
K
I
L
T
R
K
-
Q
S
---
G
I
---
Y
T
Y
T
L
---
P
E
K
W
S
D
E
--
S
IN
W
-
N
E
-------
N
K
IL
R
---
P
K
K
--
L
Y
K
N
N
C
A
F
Y
G
S
-
G
K
V
E
G
R
V
I
G
G
N
L
A
T
L
T
G
I
W
G
S
E
W
M
P
E
I
-
R
N
G
D
I
L
F
I
E
---
D
-
S
R
A
S
I
A
T
V
E
R
L
F
S
M
L
--
K
L
N
R
--
V
--
F
D
K
V
S
A
I
I
L
G
K
H
E
--
L
F-
D
C
A
G
S
K
R
R
P
Y
E
V
L
T
E
V
L
D
G
K
Q
I
P
V
L
D
G
F
D
C
S
H
T
H
P
M
L
T
L
P
L
G
V
K
L
A
I
D
F
D
N
K
N
I
S
I
T
E