@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1929: (2015-12-11 )
MSKHYFSKSVFALTVLTATATSGLAVQAEDIVTTPSSTSTKVESTTPTSTIAEEKSNVTSTPTAITDASTATSTNTTTNNQNPQPVATEATTSDLKPIEGEKVDLRIMSTTDLHTNLVNYDYYQDKESQKIGLAKTAVLIEEAKKENPNTVLVDNGDVIQGTPLGTYKAIVKPVAENEEHPMYQAMNALGYDASTLGNHEFNYGLDYLKKIIATANLPILNANVLDFKTHQPVFKTYDIITKTFKDSTGRAVALNIGITGIVPPQILNWDKANLEGKVIVKDSVKAIEEIVPTMRAKGADVILVLSHSGIGDDRYEEGEENVGYQIASIKGVDAVVTGHSHAEFPSGNGTGFYEKYTGVDGINGKINGTPVTMAGKYGDHLGIIDLGLSYTNGKWQVSESSAKIRKIDMNSTTADERIIALAKEAHDGTINYVRQQVGTTTAPITSYFALVKDDPSVQIVNNAQRWYVANELKGTPEANLPLLSAAAPFKAGTRGDATAYTDIPAGPVAIKNVADLYLYDNVTALLKVTGADLREWLEMSAGQFNQIDPNNKAPQNIINTEYRTYNFDVIDGLTYKFDITQPNKYNKDGKVVNSQASRVRDLMYNGKPVADKQEFMIVTNNYRASGTFPGAKNATMNRLLNLENRQTIINYIISEKTINPTADNNWGFTESIKDLDLRFQTADKAKNLVTNSKDIQYIASSTKDEGFGDYRFVYTEQEKVDLTEPSHQEKLSQIEKQKIHHMVATAYTKAKASPNITGTVYTQQKEKTLPKTGQEKQSYLAFFGVAILGLVGSLLKKKQI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.--..-....130-.......140....----..----.150.......160.......170.---......180.......190.......200.......210.......220.......230..----.......240...--....250.......260.......-.270.......280.......290....-...300.......310......----.-------320----......--.-.-.330.........340--........350.........360.---.------.....370.......380.......390.--------------.-----....-.400.....-----.--------.410...-....420.......430.......440..--.---.--..--.450.......460........470.......480........490.......500-------.......510.....-..520.......530.......540.......550.......560.......570.......580.......590.......600...----..-..610.......---620..--...--..630...-.-...640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
H
Y
FSK
S
V
F
A
L
T
V
L
T
ATATS
G
L
A
V
Q
A
E
D
I
VTTPSSTST
K
V
ESTTPT
S
T
I
A
E
EKSNVTSTPTAITDASTATSTNTTTNNQNPQPVATEATTSDLKPIEGE
K
V
D
L
R
I
M
S
TTDLHTNLVNYDYY--QD-KESQKIG-L
A
K
T
A
V
L
I
E
E
A
KKE----NP----
N
T
V
L
VDNG
D
V
I
QGTPL
G
T
Y
K
A
I
V
K
P---VAENEEH
P
M
Y
Q
A
M
N
A
LGYD
A
S
TLGNHE
F
N
Y
G
L
D
Y
L
K
K
I
I
A
TANLP
I
L
NA
N
V
L
DFKTH--Q
P
----
V
F
K
T
Y
D
I
I
T
K
T
FK--DSTG
R
A
V
A
L
N
IGITG-IV
P
P
QILN-WDKANLE
G
K
V
I
V
K
D
S
V
K
A
I
E
E
I
V
P
T
M
RA-KGA
D
V
I
L
V
L
SHSGIGD
D
R
YEEG----E-------E------NV
G
Y
Q
I
--
A
-S-IK--G
V
D
A
V
VTGHSH---AEFPSGNGT--G
F
Y
E
KYTGVDGIN---G------KING
T
P
V
T
M
AGKYGD
H
L
G
I
I
D
L
GLSYTNG--------------
K
-----
W
Q
VS-ESS
A
K
I
R
K
I
-----D--------MNSTTA
D
-
E
R
I
I
A
L
A
KEAHD
G
T
I
N
Y
V
R
Q
Q
VGTTTA
P
I
--
T
---
S
--
Y
F
--
A
L
VKDDPS
V
Q
I
VN-NA
Q
R
W
Y
V
A
N
ELKGTPEANL
P
-
L
L
SAAAPFKAGTRGDA
T
A
YTD-------IPAG
P
V
A
I
K
N
V
A
D
L
Y
-
L
YD
N
V
T
A
L
L
K
VT
G
A
D
L
R
E
W
L
E
MSAGQFNQIDPNNKAP
Q
N
IINTE
Y
R
T
Y
N
F
D
VIDG
L
T
Y
K
F
DITQPNKYNKDG
K
V
V
N
S
Q
A
S
R
V
R
D
L
MYN----GK-PVADK
Q
E
F
M
I
V
T---NNYRA--SGT--FPGAK
N
A
T
-
M
-
N
R
L
LNLE
N
R
Q
T
I
I
N
Y
I
ISEKTINPTADNNWGF
T
E
S
IKDL
D
L
R
F
Q
T
A
D
K
A
K
N
LVTNS
K
D
I
Q
Y
I
A
SSTKDEGFG
D
Y
R
F
V
Y
TEQEKVDLTEP
S
H
Q
E
K
L
S
Q
I
E
K
Q
K
I
H
H
M
V
A
T
A
Y
TKAKASPN
I
T
G
T
V
Y
T
Q
Q
K
EKTLPKT
G
Q
E
K
Q
S
Y
L
A
F
F
G
V
A
I
L
G
L
V
G
S
L
L
K
KKQI
28
HHSearch
90.00
48%
-65
- C2 -
3JYF
12
?
A:
[4-338]
---------------------------------------------------------------------------------------------------
A
A
T
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
Y
--
K
D
-
A
A
T
E
K
F
G
-
L
V
R
T
A
S
L
I
E
Q
A
R
A
E
----
V
K
----
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
D
Y
M
A
A
K
-
G
---
L
K
E
G
D
V
H
P
V
Y
K
A
M
N
T
L
N
Y
A
V
G
N
L
G
N
H
E
F
N
Y
G
L
D
F
L
H
K
A
L
A
G
A
K
F
P
Y
V
N
A
N
I
I
D
A
K
T
G
--
K
P
----
M
F
T
P
Y
L
I
Q
D
T
R
V
V
--
D
S
D
G
Q
I
H
T
L
R
I
G
Y
I
G
-
F
V
P
P
Q
I
M
T
-
W
D
K
A
N
L
N
G
K
V
T
V
N
D
I
T
E
T
A
R
K
Y
I
P
E
M
R
A
-
K
G
A
D
V
V
V
V
V
A
H
S
G
L
S
A
D
P
Y
Q
A
M
----
A
-------
E
------
N
S
V
Y
Y
L
--
S
-
Q
-
V
P
--
G
V
D
A
I
M
F
G
H
A
H
---
A
V
F
P
G
K
D
------
F
A
N
I
K
G
A
D
I
A
K
---
G
------
T
L
N
G
V
P
A
V
M
P
G
M
W
G
D
H
L
G
V
V
D
L
V
L
N
N
D
S
G
--------------
K
-----
W
Q
V
T
-
Q
S
K
A
E
A
R
P
I
-----
Y
DAVAK---
K
S
L
A
A
E
D
-
G
K
L
V
S
V
L
K
A
D
H
D
A
T
R
E
F
V
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.39
46%
-67
- C2 -
3JYF
12
?
A:
[7-339]
------------------------------------------------------------------------------------------------------
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
M
D
F
D
Y
Y
--
K
D
-
A
A
T
E
K
F
G
-
L
V
R
T
A
S
L
I
E
Q
A
R
A
E
----
V
K
----
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
P
L
G
D
Y
M
A
-
A
K
G
---
L
K
E
G
D
V
H
P
V
Y
K
A
M
N
T
L
N
Y
A
V
G
N
L
G
N
H
E
F
N
Y
G
L
D
F
L
H
K
A
L
A
G
A
K
F
P
Y
V
N
A
N
I
I
D
A
K
T
G
--
K
P
----
M
F
T
P
Y
L
I
Q
D
T
R
V
V
--
D
S
D
G
Q
I
H
T
L
R
I
G
Y
I
G
-
F
V
P
P
Q
I
M
T
-
W
D
K
A
N
L
N
G
K
V
T
V
N
D
I
T
E
T
A
R
K
Y
I
P
E
M
R
A
-
K
G
A
D
V
V
V
V
V
A
H
S
G
L
S
A
D
P
Y
Q
A
M
----
A
-------
E
------
N
S
V
Y
Y
L
--
S
-
Q
-
V
P
--
G
V
D
A
I
M
F
G
H
A
H
---
A
V
F
P
G
K
D
------
F
A
N
I
K
G
A
D
I
A
K
---
G
------
T
L
N
G
V
P
A
V
M
P
G
M
W
G
D
H
L
G
V
V
D
L
V
L
N
N
D
S
G
--------------
K
-----
W
Q
V
T
-
Q
S
K
A
E
A
R
P
I
YDAVA
K
--------
K
S
L
A
A
E
D
-
G
K
L
V
S
V
L
K
A
D
H
D
A
T
R
E
F
V
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.58
24%
-54
- C2 -
4Q7F
3
?
A:
[18-509]
----------------------------------------------------------------------------------------------------
S
N
I
A
F
Y
V
V
S
--
D
V
H
G
Y
I
F
P
T
D
F
T
--
S
R
-
N
Q
Y
Q
P
M
G
-
L
L
L
A
N
H
V
I
E
Q
D
R
R
Q
----
Y
D
----
Q
S
F
K
I
D
N
G
D
F
L
Q
G
S
P
F
C
N
Y
L
I
-------
A
H
S
G
S
S
Q
P
L
V
D
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
N
Y
G
L
P
Y
L
K
D
T
L
R
R
L
N
Y
P
V
L
C
A
N
I
Y
E
N
D
S
-----------
T
L
T
D
N
G
V
K
Y
F
Q
VG
D
Q
T
-------
V
G
V
I
G
-
L
T
T
Q
F
I
P
H
-
W
E
Q
P
E
H
I
Q
S
L
T
F
H
S
A
F
E
I
L
Q
Q
Y
L
P
E
M
K
--
R
H
A
D
I
I
V
V
C
Y
H
G
G
F
E
K
D
-
L
E
S
G
----
T
PTEVLTG
E
------
N
E
G
Y
A
M
L
E
A
-
F
-
S
K
--
D
I
D
I
F
I
T
G
H
Q
H
---
R
Q
--------------------
I
A
---
E
------
R
F
K
Q
T
A
V
I
Q
P
G
T
R
G
T
T
V
G
R
V
V
L
S
---
T
D
E
--------------
Y
-----
E
N
L
S
V
E
S
C
E
L
L
P
V
I
-----
D
--------
D
S
T
F
T
I
D
-
E
D
D
Q
H
L
R
K
Q
L
E
D
----
W
L
D
Y
E
I
T
T
L
P
Y
D
M
--
T
INH
A
--
F
E
--
A
R
V
A
P
H
P
F
T
N
F
M
N
------
Y
A
L
L
E
K
S
D
A
D
V
A
C
T
A
-
L
F
D
S
A
S
G
F
K
Q
----------------------
V
V
T
M
R
D
V
I
N
N
Y
-
P
F
P
N
T
F
K
V
L
A
V
S
G
A
K
L
K
E
A
I
E
R
S
A
E
Y
F
D
V
K
N
D
E
V
S
V
S
A
D
F
L
E
P
K
P
Q
H
F
N
Y
D
I
Y
G
G
V
S
Y
T
I
H
V
G
R
P
------------
K
G
Q
R
V
S
N
M
M
I
Q
----
G
H
-
A
V
D
L
K
Q
T
Y
T
I
C
V
---
N
N
Y
R
A
V
G
G
G
Q
--
Y
D
M
Y
I
D
A
P
-
V
-
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
N
N
L
M
R
I
P
Q
V
V
D
F
K
V
E
K
----------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
87.27
45%
-65
- C2 -
3GVE
3
NTPES_BACSU
A:
[8-341]
----------------------------------------------------------------------------------------------------
P
Q
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
M
D
Y
D
Y
Y
--
S
D
-
K
E
T
A
D
F
G
-
L
A
R
T
A
Q
L
I
Q
K
H
R
E
Q
----
N
P
----
N
T
L
L
V
D
N
G
D
L
I
Q
G
N
P
L
G
E
Y
A
V
K
Y
Q
K
D
D
I
I
S
G
T
K
T
H
P
I
I
S
V
M
N
A
L
K
Y
D
A
G
T
L
G
N
H
E
F
N
Y
G
L
D
F
L
D
G
T
I
K
G
A
D
F
P
I
V
N
A
N
V
K
T
T
S
-
G
--
E
N
----
R
Y
T
P
Y
V
I
N
E
K
T
L
I
--
D
E
N
G
N
E
Q
K
V
K
V
G
Y
I
G
-
F
V
P
P
Q
I
M
T
-
W
D
K
K
N
L
E
G
Q
V
Q
V
Q
D
I
V
E
S
A
N
E
T
I
P
K
M
K
A
-
E
G
A
D
V
I
I
A
L
A
H
T
G
I
E
K
Q
A
Q
S
S
G
----
A
-------
E
------
N
A
V
F
D
L
--
A
T
K
-
T
K
--
G
I
D
A
I
I
S
G
H
Q
H
---
G
L
F
P
S
A
------
E
Y
A
G
V
A
Q
F
N
V
E
K
---
G
------
T
I
N
G
I
P
V
V
M
P
S
S
W
G
K
Y
L
G
V
I
D
L
K
L
E
K
A
D
G
--------------
S
-----
W
K
V
A
-
D
S
K
G
S
I
E
S
I
-----
A
--------
G
N
V
T
S
R
N
-
E
T
V
T
N
T
I
Q
Q
T
H
Q
N
T
L
E
Y
V
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.89
43%
-66
- C2 -
3GVE
3
NTPES_BACSU
A:
[9-341]
-----------------------------------------------------------------------------------------------------
Q
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
M
D
Y
D
Y
Y
--
S
D
-
K
E
T
A
D
F
G
-
L
A
R
T
A
Q
L
I
Q
K
H
R
E
Q
----
N
P
----
N
T
L
L
V
D
N
G
D
L
I
Q
G
N
P
L
G
E
Y
A
V
K
Y
Q
K
D
D
I
I
S
G
T
K
T
H
P
I
I
S
V
M
N
A
L
K
Y
D
A
G
T
L
G
N
H
E
F
N
Y
G
L
D
F
L
D
G
T
I
K
G
A
D
F
P
I
V
N
A
N
V
-
K
T
T
S
G
--
E
N
----
R
Y
T
P
Y
V
I
N
E
K
T
L
I
--
D
E
N
G
N
E
Q
K
V
K
V
G
Y
I
G
-
F
V
P
P
Q
I
M
T
-
W
D
K
K
N
L
E
G
Q
V
Q
V
Q
D
I
V
E
S
A
N
E
T
I
P
K
M
K
A
-
E
G
A
D
V
I
I
A
L
A
H
T
G
I
E
K
Q
A
Q
S
S
G
----
A
-------
E
------
N
A
V
F
D
L
--
A
-
T
K
T
K
--
G
I
D
A
I
I
S
G
H
Q
H
---
G
L
F
P
S
A
---------
E
Y
A
G
V
A
Q
F
N
VEK
G
------
T
I
N
G
I
P
V
V
M
P
S
S
W
G
K
Y
L
G
V
I
D
L
K
L
E
K
A
D
G
--------------
S
-----
W
K
V
A
-
D
S
K
G
S
I
E
S
I
-----
A
--------
G
N
V
T
S
R
N
-
E
T
V
T
N
T
I
Q
Q
T
H
Q
N
T
L
E
Y
V
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.74
24%
-55
- C2 -
3QFK
4
?
A:
[18-509]
----------------------------------------------------------------------------------------------------
S
N
I
A
F
Y
V
V
S
--
D
V
H
G
Y
I
F
P
T
D
F
T
--
S
R
-
N
Q
Y
Q
P
M
G
-
L
L
L
A
N
H
V
I
E
Q
D
R
R
Q
----
Y
D
----
Q
S
F
K
I
D
N
G
D
F
L
Q
G
S
P
F
C
N
Y
L
I
-------
A
H
S
G
S
S
Q
P
L
V
D
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
N
Y
G
L
P
Y
L
K
D
T
L
R
R
L
N
Y
P
V
L
C
A
N
I
Y
E
N
D
S
-----------
T
L
T
D
N
G
V
K
Y
F
Q
VG
D
Q
T
-------
V
G
V
I
G
-
L
T
T
Q
F
I
P
H
-
W
E
Q
P
E
H
I
Q
S
L
T
F
H
S
A
F
E
I
L
Q
Q
Y
L
P
E
M
K
--
R
H
A
D
I
I
V
V
C
Y
H
G
G
F
E
K
D
-
L
E
S
G
----
T
PTEVLTG
E
------
N
E
G
Y
A
M
L
E
A
-
F
-
S
K
--
D
I
D
I
F
I
T
G
H
Q
H
---
R
Q
--------------------
I
A
---
E
------
R
F
K
Q
T
A
V
I
Q
P
G
T
R
G
T
T
V
G
R
V
V
L
S
---
T
D
E
--------------
Y
-----
E
N
L
S
V
E
S
C
E
L
L
P
V
I
-----
D
--------
D
S
T
F
T
I
D
-
E
D
D
Q
H
L
R
K
Q
L
E
D
----
W
L
D
Y
E
I
T
T
L
P
Y
D
M
--
T
INH
A
--
F
E
--
A
R
V
A
P
H
P
F
T
N
F
M
N
------
Y
A
L
L
E
K
S
D
A
D
V
A
C
T
A
-
L
F
D
S
A
S
G
F
K
Q
----------------------
V
V
T
M
R
D
V
I
N
N
Y
-
P
F
P
N
T
F
K
V
L
A
V
S
G
A
K
L
K
E
A
I
E
R
S
A
E
Y
F
D
V
K
N
D
E
V
S
V
S
A
D
F
L
E
P
K
P
Q
H
F
N
Y
D
I
Y
G
G
V
S
Y
T
I
H
V
G
R
P
------------
K
G
Q
R
V
S
N
M
M
I
Q
----
G
H
-
A
V
D
L
K
Q
T
Y
T
I
C
V
---
N
N
Y
R
A
V
G
G
G
Q
--
Y
D
M
Y
I
D
A
P
-
V
-
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
N
N
L
M
R
I
P
Q
V
V
D
F
K
V
E
K
----------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
84.42
21%
-55
- C2 -
2Z1A
4
?
A:
[28-534]
------------------------------------------------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
T
--
L
S
G
E
K
T
P
V
G
G
-
V
A
R
R
V
A
L
F
D
R
V
W
A
R
----
A
K
----
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
------------
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
S
R
E
P
RL
K
G
----
L
F
A
P
Y
A
V
V
V
V
-----------
G
G
E
R
V
G
I
I
G
-
L
T
T
P
D
T
R
E
-
I
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
D
L
---------------------------
K
L
--
A
R
R
-
L
V
--
G
V
Q
V
I
V
G
G
H
S
H
---
T
L
L
G
S
F
P
H
K
EL
S
P
A
G
P
Y
P
-
T
V
V
K
N
---
P
------
E
G
K
D
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
A
K
G
---------------
E
-----
L
L
---
A
Y
K
G
E
A
L
L
M
-----
T
--------
P
E
A
A
P
E
D
-
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
--
V
---
G
--
E
R
AV
V
R
R
R
E
S
N
L
G
N
L
I
T
-
D
G
M
L
W
K
T
R
N
-----
A
G
T
Q
I
A
-
L
Q
-----------
N
G
G
G
I
R
A
S
-------
I
P
K
G
P
I
T
V
G
K
V
Y
E
V
L
-
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
N
T
----------------
A
G
R
F
L
Q
V
S
G
L
R
Y
A
F
D
L
S
R
P
A
------------
G
S
R
V
V
R
V
E
V
K
T
EKG
Y
V
-
P
L
D
L
E
A
T
Y
R
V
V
V
---
N
N
F
I
A
--
N
G
G
DG
F
T
V
L
K
E
A
Q
-
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
--------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
81.61
23%
-53
* C2 *
3IVE
5
?
A:
[4-501]
-----------------------------------------------------------------------------------------------------
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
WI
A
D
-
G
K
R
D
I
G
G
-
W
A
N
I
T
T
L
V
K
Q
E
K
A
K
----
N
K
----
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
S
S
L
T
------------
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
N
S
S
--
K
S
F---
W
D
K
P
Y
T
I
I
E
K
-----------
D
G
V
K
I
G
V
I
G
-
L
H
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
K
V
D
L
T
V
A
L
I
H
E
G
V
P
A
R
Q
S
S
M
-D
V
R
R
A
-------
L
------
D
K
D
I
Q
T
--
A
S
Q
-
V
K
--
G
L
D
I
L
I
T
G
H
A
H
---
V
G
T
P
E
P
I
---------------------------
K
V
G
N
T
L
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
K
E
K
P
H
--------------
N
-----
F
T
V
K
-
N
--
F
E
L
K
T
I
-----
Y
--------
A
D
E
W
K
P
D
-
Q
Q
T
K
Q
V
I
D
G
W
N
K
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
--
K
---
R
------
A
Y
G
E
S
A
S
L
G
N
L
A
A
-
D
A
L
L
A
A
A
G
K
------
N
T
Q
L
A
-
L
T
-----------
N
S
G
G
I
R
N
E
-------
I
P
A
G
A
I
T
M
G
G
V
I
S
T
F
-
P
F
P
N
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
N
-------------------
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
V
------------
G
Q
R
V
I
T
L
T
L
N
----
G
K
-
P
I
E
D
A
T
V
Y
H
I
A
T
---
Q
S
F
L
A
--
D
G
G
DG
F
T
A
F
T
E
G
K
A
R
-
N
I
T
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
G
N
T
I
T
D
E
Q
L
N
G
M
R
V
K
D
I
K
--------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.21
22%
-37
- C2 -
4WWL
15
USHA_ECOLI
A:
[10-477]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
-----
K
K
V
T
-
W
E
D
G
K
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
C
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.14
22%
-37
- C2 -
1HPU
3
USHA_ECOLI
A:
[10-477]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
EMKMV
N
Y
Q
L
I
P
VN
L
K
-----
K
K
V
T
-
W
E
D
G
K
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.89
22%
-35
- C2 -
1HO5
4
USHA_ECOLI
A:
[10-477]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
EMKMV
N
Y
Q
L
I
P
VN
L
K
-----
K
K
V
T
-
W
E
D
G
K
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.67
22%
-39
- C2 -
1OI8
4
USHA_ECOLI
A:
[10-477]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
--------
V
C
E
S
---
D
L
Q
D
A
E
-
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
-----
K
K
V
T
-
W
E
D
G
K
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
C
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
E
-----------------------------------------------------------------------------------------------------------------------------
26
HHSearch
77.28
19%
-57
- C2 -
1HP1
7
USHA_ECOLI
A:
[5-504]
----------------------------------------------------------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
---------
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
-----------
Q
D
L
K
I
A
V
I
G
-
L
T
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
G
S
----
N
-------
A
------
P
G
D
V
E
M
--
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
---
D
P
V
C
M
A
A
E
N
K-
K
Q
V
D
Y
V
P
G
T
P
C
K
P
---
D
------
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
----------------
E
-----
M
K
M
V
-
N
--
Y
Q
L
I
P
V
-----
N
LKKKRVLY
T
P
E
I
A
E
N
-
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
--
E
---
G
D
R
D
K
--
V
R
F
V
Q
T
N
M
G
R
L
I
L
-
A
A
Q
M
D
R
T
--------
G
A
D
F
A
-
V
M
-----------
S
G
G
G
I
R
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
D
-----------------
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
K
-----------------
D
G
K
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
DG
Y
P
R
L
D
N
K
P
-
G
-
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
--------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.09
23%
-47
- C2 -
2Z1A
4
?
A:
[30-485]
--------------------------------------------------------------------------------------------------------
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
T
--
L
S
-
G
E
K
T
P
V
G
G
V
A
R
R
V
A
L
F
D
R
V
W
A
R
----
A
K
----
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
---
L
Y
F
N
Q
Y
R
G
---
L
A
D
R
------
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
--
D
A
S
R
--
E
P
RLKG
L
F
A
P
Y
A
V
V
V
V
G
G
E
--
R
V
G
---------
I
I
G
-
L
T
T
P
D
--
T
-
R
E
I
S
N
P
G
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
D
---------------------------
L
K
L
--
A
R
R
-
L
V
--
G
V
Q
V
I
V
G
G
H
S
H
T
L
L
G
S
F
P
H
K
E
L
S
--
P
A
G
P
Y
P
T
V
V
K
N
P
E
---
G
------
K
--
D
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
-
A
K
G
--------------
E
-----
L
L
A
Y
-
K
G
E
A
L
L
-----------------
M
T
P
E
A
A
P
-
E
D
F
--
F
A
K
E
A
---
L
L
A
Y
A
Q
--------
P
V
--
M
---
A
--
L
M
--
Q
Q
V
I
A
E
A
K
V
D
L
V
G
---
E
R
A
V
V
R
R
R
-----
E
S
N
L
G
N
L
I
T
D
G
M
L
W
K
T
R
N
A
G
T
Q
I
A
L
Q
N
GGGIR
A
S
I
P
K
G
P
I
T
V
G
K
V
Y
E
V
L
-
P
F
G
N
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
-------------
N
T
A
G
R
---
F
L
Q
V
S
G
L
R
Y
A
F
D
L
S
R
P
---------
A
G
S
R
V
V
R
V
E
V
K
T
E
K
----
G
Y
V
P
L
D
L
E
A
T
Y
R
V
V
V
---
N
N
F
I
A
--
N
G
G
--
D
G
F
T
V
L
K
E
-
A
-
Q
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
-----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.88
22%
-38
- C2 -
1OID
1
USHA_ECOLI
A:
[10-477]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GCNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
-----
K
K
V
T
-
W
E
D
G
K
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
C
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------------------------------------------------------------------------------------------
46
Fugue
76.41
17%
-42
- C2 -
2WDC
18
?
A:
[21-562]
----
Y
D
L
P
P
Y
G
D
A
T
L
L
Y
F
S
D
L
H
G
--------------
Q
A
F
P
H
Y
F
M
E
P
P
N
L
I
A
--
P
K
P
L
M
G
R
P
G
Y
L
T
G
E
A
I
L
R
Y
Y
G
V
E
R
G
T
----------------------
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
F
G
P
I
--
G
--------
G
-
M
G
A
L
T
A
L
I
R
D
Q
K
A
R
----
V
E
A
E
G
G
K
A
L
V
L
D
G
G
D
T
W
T
N
S
G
L
S
L
L
------------
T
R
G
E
A
V
V
R
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
T
L
G
R
E
R
V
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
I
V
D
D
L
F
G
--
D
P
----
L
F
P
A
Y
R
I
H
R
V
G
-----------
P
Y
A
L
A
V
V
G
-
A
S
Y
P
Y
V
K
V
-
S
H
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
H
N
G
---------------------
M
------
Q
L
D
A
A
L
--
A
-
E
R
I
R
--
G
I
D
L
I
L
S
G
H
T
H
---
D
L
T
P
R
------------------
P
---
W
------
R
V
G
K
T
W
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
W
------------------
K
-----
G
G
I
A
-
N
L
R
V
R
V
L
P
V
-----
L
--------
A
E
H
L
P
K
A
-
E
D
V
E
A
F
L
K
A
Q
L
A
P
H
Q
D
H
L
F
T
P
L
A
V
S
E
T
L
L
Y
K
R
---
D
--
T
L
--
Y
S
T
W
D
Q
L
V
G
E
A
V
K
-
A
I
Y
P
-------------------
E
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
----------
L
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
T
S
D
P
F
Y
Q
Q
G
G
D
V
S
----------
R
V
F
G
L
R
Y
V
L
D
P
D
A
P
T
G
------------
E
R
V
R
E
V
E
V
G
----
G
R
-
P
L
D
P
N
R
R
Y
L
A
A
A
Y
GG
R
L
Q
R
V
--
G
E
A
--
K
P
G
Y
E
P
R
P
----------
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
R
P
E
P
N
------------------------------------------------------------------------------
V
K
V
I
G
R
N
Y
R
L
P
E
V
T
G
------------------------------------------
7
PsiBlast_PDB
76.27
22%
-36
- C2 -
2USH
7
USHA_ECOLI
A:
[35-502]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K-----
Y
F
T
-----
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VN
L
K
-----
K
K
V
-------
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
---------------
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
-------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.13
22%
-34
- C2 -
1USH
7
USHA_ECOLI
A:
[35-502]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
T
-----
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VNL
K
-----
K
-----------
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.03
22%
-32
- C2 -
1HP1
7
USHA_ECOLI
A:
[10-468]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GSNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
--------------
E
M
K
M
V
N
Y
Q
L
I
-
P
V
N
L
K
K
K
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.83
22%
-37
- C2 -
1OIE
1
USHA_ECOLI
A:
[10-477]
--------------------------------------------------------------------------------------------------------------
T
V
L
H
T
N
-
D
H
H
G
H
F
--
W
R
-
N
E
Y
G
E
Y
G
-
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
D
L
Q
------------
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
G
--
E
R
----
L
F
K
P
W
A
L
F
K
R
--
Q
--
D
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
N
P
E
Y
F
-----
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
----
P
D
I
I
I
A
A
T
H
M
G
----
H
Y
D
N
G
----
E
-------
H
GCNAPG
D
V
E
M
A
R
--
A
-
L
-
P
A
--
G
S
L
A
M
I
V
G
-
G
H
---
S
Q
D
P
V
C
M
A
A
-----
E
N
K
K
Q
V
D
Y
V
P
---
G
T
P
C
K
P
D
Q
Q
N
G
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
--
F
E
F
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
VNL
K
-----
K
K
V
-------
S
E
R
V
-----
L
--------
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
---------------
R
L
E
G
D
R
D
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
-
G
A
D
F
A
-
V
M
S
G
-----
G
G
I
R
------
D
S
-------
I
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
-
P
F
G
N
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
----
Q
M
K
P
D
S
G
A
Y
P
Q
F
A
N
V
S
F
V
A
----------------------
K
D
G
K
--------
L
N
D
L
K
I
K
----
G
E
-
P
V
D
P
A
K
T
Y
R
M
A
T
---
L
N
F
N
A
--
T
G
G
--
D
G
Y
P
R
L
D
N
-
K
-
C
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
E
-----------------------------------------------------------------------------------------------------------------------------