@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1931: (2015-12-11 )
METTLNYIKTLTSIPSPTGFTQTIMTYIIKELEAFGYSPIRTNKGGVMVSLKGKNDTKHRMITAHLDTLGAMVRAIKPDGRLKIDLIGGYTYNAIEGENCTIHLSKNGKEISGTALIHQTSVHVYKDAGTAERNQTNMEIRLDEKVTTADETRALGIQVGDFISFDPRTIITDSGFIKSRYLDDKVSAGILMELLSVYKKEDIQLPYTTHFYFSAFEELGHGANSSIPNETVEYLAVDMGAMGDDQETDEYTVSICVKDASGPYHYELRQHLVSLAENNNIPYKLDIYPYYGSDASAAMRAGAEVKHALLGAGIESSHSYERTHIDSIQATELLVDAYLKSNMVD
Atome Classification :
(20 SA)
.........10........20-.-.......30....--....40..--------.....-.50.-..--.....60........70........80........90......-----..100.......110.......120......-.-130......------.140--........150.......160.--......170-.-.....------.180----........190.......--200.......210.......220--.........---230-.---.-..--.-----------..240---...---.-------.--------------------------------------...----------------250--------.---------------------------------------------......260--.-----..----...------..---.270.......280......-.290----........300.......310.......-320..-.....330.......340...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ME
T
T
L
N
Y
I
K
T
L
TSIPSPT
G
F
T
-
Q
-
T
I
M
T
Y
I
I
K
E
L
E
A
F--GYSPIRTN--------KG
G
V
M
-
V
S
L
K-GK--NDTK
H
R
M
I
T
A
H
L
D
T
L
G
A
M
V
R
AIKPD
G
R
L
K
I
D
L
IG
G
Y
T
YNAIEG-----E
N
C
T
I
H
LSKNGKEIS
G
T
A
L
I
H
Q
T
S
V
H
V
Y
KDA-G-TAERNQT
N
M
------
E
I
R
---LDEKVTTADE
T
R
A
L
G
I
Q
VG
D
F
I--SFDP
R
T
I
IT-D-SGFIK------SR-Y----LD
D
K
V
S
A
G
I
L
M
E
L
L
S
V
Y
K
--KEDIQLPYTT
H
F
Y
F
S
A
F
E
E
LG----HGANSSI
P
N
---
E
T
V
-
E
---
Y
-
L
A
--
V
-----------
D
MGA----MGD---D-------Q--------------------------------------ETD----------------
E
Y
T
--------
V
---------------------------------------------
S
I
C
V
KDA----S-----GP----
Y
H
Y
------
E
L
---
R
Q
H
L
V
S
L
AENNNI
P
Y
K
L
D
I
Y
-
P
Y-Y----GS
D
A
S
A
A
M
RA
G
A
E
V
K
H
A
L
LGAGIESSHS-YERTH-ID
S
I
Q
A
T
E
L
L
V
D
A
Y
L
K
SNMVD
1
PsiBlast_PDB
99.26
60%
-108
- C3 -
2GRE
1
?
A:
[8-348]
---
T
M
E
L
I
K
E
L
V
S
I
P
S
P
S
G
N
T
-
A
-
K
I
I
N
F
I
E
N
Y
V
S
E
W
--
N
V
E
T
K
R
N
N
--------
K
G
A
L
I
-
L
T
V
K
-
G
K
--
N
D
A
Q
H
R
L
L
T
A
H
V
D
T
L
G
A
M
V
K
E
I
K
P
D
G
R
L
S
L
S
M
I
G
G
F
R
W
N
S
V
E
G
-----
E
Y
C
E
I
E
T
S
-
S
G
K
T
Y
T
G
T
I
L
M
H
---------------------
I
------
E
V
R
---
I
D
E
R
V
F
S
A
D
E
V
R
E
L
G
I
E
V
G
D
F
V
--
S
F
D
P
R
V
Q
I
T
-
E
-
S
G
Y
I
K
------
S
R
-
H
----
L
D
D
K
V
S
V
A
I
L
L
K
L
I
K
R
L
Q
--
D
E
N
V
T
L
P
Y
T
T
H
F
L
I
S
N
N
E
--------
G
G
N
S
N
I
P
E
---
E
T
V
-
E
---
Y
-
L
A
--
V
-----------
D
M
G
A
----
L
G
D
---
G
-----------------------------------------------
S
D
----------------
E
Y
T
--------
V
---------------------------------------------
S
I
C
A
K
D
S
----
S
-----
G
P
----
Y
H
Y
------
A
L
---
R
K
H
L
V
E
L
A
K
T
N
H
I
E
Y
K
V
D
I
Y
-
P
Y
-
Y
------------
R
A
G
F
D
V
K
H
A
L
I
G
A
G
I
D
S
S
H
A
-
F
E
R
T
H
-
E
S
S
I
A
H
T
E
A
L
V
Y
A
Y
V
M
S
N
L
I
E
18
HHSearch
98.56
60%
-104
- C3 -
2GRE
1
?
A:
[6-346]
-
K
E
T
M
E
L
I
K
E
L
V
S
I
P
S
P
S
G
N
T
-
A
-
K
I
I
N
F
I
E
N
Y
V
S
E
W
--
N
V
E
T
K
R
N
N
--------
K
G
A
L
I
-
L
T
V
K
-
G
K
--
N
D
A
Q
H
R
L
L
T
A
H
V
D
T
L
G
A
M
V
K
E
I
K
P
D
G
R
L
S
L
S
M
I
G
G
F
R
W
N
S
V
E
G
-----
E
Y
C
E
I
E
T
S
S
-
G
K
T
Y
T
G
T
I
L
M
H
-------------------
I
E
V
------
R
-----
I
D
E
R
V
F
S
A
D
E
V
R
E
L
G
I
E
V
G
D
F
V
--
S
F
D
P
R
V
Q
I
T
-
E
-
S
G
Y
I
K
------
S
R
-
H
----
L
D
D
K
V
S
V
A
I
L
L
K
L
I
K
R
L
Q
--
D
E
N
V
T
L
P
Y
T
T
H
F
L
I
S
N
N
E
--------
G
G
N
S
N
I
P
E
---
E
T
V
-
E
---
Y
-
L
A
--
V
-----------
D
M
G
A
----
L
G
D
---
G
-----------------------------------------------
S
D
----------------
E
Y
T
--------
V
---------------------------------------------
S
I
C
A
K
D
S
----
S
-----
G
P
----
Y
H
Y
------
A
L
---
R
K
H
L
V
E
L
A
K
T
N
H
I
E
Y
K
V
D
I
Y
-
P
Y
-
Y
------------
R
A
G
F
D
V
K
H
A
L
I
G
A
G
I
D
S
S
H
A
-
F
E
R
T
H
-
E
S
S
I
A
H
T
E
A
L
V
Y
A
Y
V
M
S
N
L
I
E
7
PsiBlast_PDB
68.27
23%
-71
- C3 -
3KL9
2
?
A:
[2-342]
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
-
P
V
R
A
Y
L
R
E
K
L
T
P
H
--
V
D
E
V
V
T
D
G
--------
L
G
G
I
F
G
I
K
H
S
-
E
A
--
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
-----
Q
R
F
K
L
-
L
T
R
D
G
H
E
I
P
--
V
I
S
G
-----------------
P
A
I
-
A
------
D
I
V
---
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
--
V
P
D
S
S
A
I
L
T
A
N
-
E
K
N
I
I
------
S
K
-
A
----
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
--
G
Q
--
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L---
R
G
A
H
T
S
T
T
K
---
F
D
P
-
E
V
--
F
-
L
A
--
V
-----------
D
C
S
P
----
A
G
-----------------------------------------------------
D
----------------
V
Y
G
--------
G
---------------------------------------------
Q
G
K
I
G
D
G
----
T
LIRFY
D
P
----
G
H
L
------
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
------
Y
-
Y
C
G
KG
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
-
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
20
HHSearch
66.87
20%
-72
- C3 -
1YLO
2
?
A:
[3-338]
-
A
M
D
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
S
E
-
Q
-
E
V
R
Q
I
L
L
E
E
A
A
R
L
--
Q
K
E
V
R
F
D
G
--------
L
G
S
V
L
-
I
R
L
N
-
E
S
---
T
G
P
K
V
M
I
C
A
H
M
D
E
V
G
F
M
V
R
S
I
S
R
E
G
A
I
D
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
-----
Q
P
V
R
I
T
T
R
E
-
E
C
K
I
P
G
L
L
D
G
------------
D
-
R
Q
G
N
D
V
S
A
M
------
R
-----
V
D
I
G
A
R
T
Y
D
E
V
M
Q
A
G
I
R
P
G
D
R
V
--
T
F
D
T
T
F
Q
V
L
-
P
-
H
Q
R
V
M
------
G
K
-
A
----
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
R
E
L
H
--
D
A
--
E
L
P
A
E
V
W
L
V
A
S
S
S
E
E
V
G
----
L
R
G
G
Q
T
A
T
R
A
V
-
S
P
D
-
V
---
A
-
I
V
--
L
-----------
D
T
A
C
----
W
A
K
---
N
-------
F
DYGAANH-------------------------------
R
Q
I
----------------
G
N
G
--------
P
---------------------------------------------
M
L
V
L
S
D
K
----
S
-----
L
I
----
A
P
P
------
K
L
---
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
F
-
S
N
-
G
----
G
T
D
G
G
A
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
A
A
S
I
A
D
-
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
R
E
26
HHSearch
66.81
21%
-67
- C3 -
1VHE
1
YSDC_BACSU
A:
[7-354]
-
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
-
R
-
E
V
R
Q
V
M
K
S
Y
I
E
P
F
--
A
D
E
V
T
T
D
R
--------
L
G
S
L
I
-
A
K
K
T
-
G
A
--
E
N
G
P
K
I
M
I
A
G
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
-----
Q
R
V
T
I
V
T
K
--
K
G
E
I
T
G
V
I
G
S
--
K
P
P
H
I
L
S
P
E
A
R
-
K
K
S
V
E
I
K
D
M
------
F
-----
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
--
V
P
H
F
E
F
T
V
M
-
N
N
E
K
F
L
L
------
A
K
-
A
----
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
--
N
T
--
D
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
----
L
R
G
A
K
T
A
A
H
T
I
-
Q
P
D
-
I
---
A
-
F
G
--
V
-----------
D
V
G
I
----
A
G
D
---
T
-------
P
GISEKEAQ------------------------------
S
K
M
----------------
G
K
G
--------
P
---------------------------------------------
Q
I
I
V
Y
D
A
----
S
-----
M
V
----
S
H
K
------
G
L
---
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
-
A
G
-
G
----
G
T
D
S
G
A
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
-
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
K
19
HHSearch
66.58
22%
-65
- C3 -
3KL9
2
?
A:
[2-346]
M
T
T
L
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
-
A
-
P
V
R
A
Y
L
R
E
K
L
T
P
H
--
V
D
E
V
V
T
D
G
--------
L
G
G
I
F
-
G
I
K
H
-
S
E
A-
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
-----
Q
R
F
K
L
L
T
R
D
-
G
H
E
I
P
V
I
S
G
------------------
P
A
I
A
D
I
------
V
-----
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
--
V
P
D
S
S
A
I
L
T
-
A
N
E
K
N
I
I
------
S
K
-
A
----
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
S
--
G
Q
--
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
----
L
R
G
A
H
T
S
T
T
K
F
-
D
P
E
-
V
---
F
-
L
A
--
V
-----------
D
C
S
P
----
A
G
D
---
V
-------
Y
GGQ-----------------------------------
G
K
I
----------------
G
D
G
--------
T
---------------------------------------------
L
I
R
F
Y
D
P
----
G
-----
H
L
----
L
L
P
------
G
M
---
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
Y
C
G
--
K
-
G
----
G
T
D
A
G
A
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
-
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
23
HHSearch
64.82
21%
-80
- C3 -
2FVG
3
?
A:
[2-335]
-----
M
Y
L
K
E
L
S
M
M
P
G
V
S
G
D
E
-
G
-
K
V
R
D
F
I
K
S
K
I
E
G
L
--
V
D
N
L
Y
T
D
V
--------
L
G
N
L
I
-
A
L
K
R
-
G
R
--
D
S
S
K
K
L
L
V
S
A
H
M
D
E
V
G
F
V
V
S
K
I
E
K
D
G
K
V
S
F
L
P
V
G
G
V
D
P
R
I
L
P
G
-----
K
V
V
Q
V
K
N
L
K
------
G
V
I
G
Y
--
R
-------------
P
P
R
F
E
N
L
------
R
-----
I
D
F
G
F
S
S
A
D
E
A
K
K
-
Y
V
S
I
G
D
Y
V
--
S
F
V
S
D
Y
I
E
--
K
-
N
G
R
A
V
------
G
K
-
A
----
F
D
D
R
A
G
C
S
V
L
I
D
V
L
E
S
G
V
--
S
----
P
A
Y
D
T
Y
F
V
F
T
V
Q
E
E
---------
S
A
V
V
V
E
Q
L
-
K
P
T
-
C
---
A
-
I
V
--
V
-----------
E
T
T
T
----
A
G
D
---
N
-------
P
ELEERKWA------------------------------
T
H
L
----------------
G
D
G
--------
P
---------------------------------------------
A
I
T
F
Y
H
R
----
G
-----
Y
V
----
I
P
K
------
E
I
---
F
Q
T
I
V
D
T
A
K
N
N
D
I
P
F
Q
M
K
R
R
-
T
------------------
Y
G
V
P
A
G
V
I
S
T
P
A
R
Y
I
H
S
P
N
S
I
I
D
-
L
N
D
Y
E
N
T
K
K
L
I
K
V
L
V
E
E
G
K
I
V
24
HHSearch
64.45
22%
-65
- C3 -
2WYR
2
?
A:
[2-332]
-
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
-
E
-
R
I
R
E
E
I
I
R
E
I
K
D
F
--
A
-
D
Y
K
V
D
A
--------
I
G
N
L
I
-
V
E
L
G
-
E
----
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
-----
R
H
V
N
V
V
T
E
--
K
G
I
L
D
G
V
I
G
A
--
T
P
P
H
L
-------
K
S
V
I
P
W
Y
D
L
------
V
-----
I
D
I
G
A
E
S
K
E
E
A
L
E
-
L
V
K
P
L
D
F
A
--
V
F
K
K
H
F
S
V
L
-
N
-
G
K
Y
V
S
------
T
R
-
G
----
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
V
--
D
H
--
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
----
L
K
G
A
K
F
L
A
N
H
Y
-
Y
P
Q
-
Y
---
A
-
F
A
--
I
-----------
D
S
F
A
----
C
C
S
PLT
G
-------
D
--------------------------------------
V
K
L
----------------
G
K
G
--------
P
---------------------------------------------
V
I
R
A
V
D
N
----
S
-----
A
I
----
Y
S
R
------
D
L
---
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
--
G
-
G
----
G
T
D
A
S
A
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
-
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
---
8
PsiBlast_PDB
64.23
22%
-82
- C3 -
3ISX
3
?
A:
[17-341]
-------
I
R
K
L
T
E
A
F
G
P
S
G
R
E
-
E
-
E
V
R
S
I
I
L
E
E
L
E
G
H
ID
G
H
---
R
I
D
--------
G
L
G
N
L
-
I
V
W
K
-
G
S
--
G
E
-
K
K
V
I
L
D
A
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
N
G
T
I
G
V
-------------------
V
G
M
E
G
-
E
-
T
T
E
E
R
Q
E
N
V
R
K
LSFD
K
L
F
---
I
D
I
G
A
N
S
R
E
E
A
Q
K
M
-
C
P
I
G
S
F
G
--
V
Y
D
---------
S
G
F
V
E
V
SG
K
Y
V
S
K
-
A
----
M
D
D
R
I
G
C
A
V
I
V
E
---
V
F
K
--
R
--
I
K
P
A
V
T
L
Y
G
V
F
S
V
Q
E
E
V
G
LVGA
S
V
A
G
Y
G
V
P
A
---
D
---
E
---
A
-
I
A
--
I
-----------
D
V
T
D
----
S
A
D
---
T
-------
P
--------------------------------------
K
A
I
----------------
K
R
H
--------
A
MRLSG
G
P
--------------------------------------
A
L
K
V
K
D
R
----
A
-----
S
I
----
S
S
K
------
R
I
---
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
-
T
F
-
G
----
G
T
N
A
M
G
Y
Q
R
T
R
E
G
I
P
S
A
T
V
S
I
P
T
R
Y
V
H
S
P
S
E
M
I
A
-
P
D
D
V
E
A
T
V
D
L
L
I
R
Y
L
G
A
----
6
PsiBlast_PDB
64.23
22%
-80
- C3 -
4P6Y
-
?
A:
[5-329]
-------
I
R
K
L
T
E
A
F
G
P
S
G
R
E
-
E
-
E
V
R
S
I
I
L
E
E
L
E
G
H
ID
G
H
---
R
I
D
--------
G
L
G
N
L
-
I
V
W
K
-
G
S
--
G
E
-
K
K
V
I
L
D
A
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
K
R
I
R
F
E
N
G
T
I
G
V
-------------------
V
G
M
E
G
-
E
-
T
T
E
E
R
Q
E
N
V
R
KLSFD
K
L
F
---
I
D
I
G
A
N
S
R
E
E
A
Q
K
M
-
C
P
I
G
S
F
G
--
V
Y
D
---------
S
G
F
V
E
V
SG
K
Y
V
S
K
-
A
----
M
D
D
R
I
G
C
A
V
I
V
E
---
V
F
K
--
R
--
I
K
P
A
V
T
L
Y
G
V
F
S
V
Q
E
E
V
G
L
V
G
A
S
V
A
G
Y
G
V
P
A
---
D
---
E
---
A
-
I
A
--
I
-----------
D
V
T
D
----
S
A
D
---
T
-------
P
--------------------------------------
K
A
I
----------------
K
R
H
--------
A
MRLSG
G
P
--------------------------------------
A
L
K
V
K
D
R
----
A
-----
S
I
----
S
S
K
------
R
I
---
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
-
T
F
-
G
----
G
T
N
A
M
G
Y
Q
R
T
R
E
G
I
P
S
A
T
V
S
I
P
T
R
Y
V
H
S
P
S
E
M
I
A
-
P
D
D
V
E
A
T
V
D
L
L
I
R
Y
L
G
A
----
21
HHSearch
64.16
20%
-73
- C3 -
2WZN
6
?
A:
[9-349]
-
M
V
D
W
K
L
M
Q
E
I
I
E
A
P
G
V
S
G
Y
E
-
H
L
G
I
R
D
I
V
V
D
V
L
K
E
V
--
A
D
E
V
K
V
D
K
--------
L
G
N
V
I
-
A
H
F
K
-
G
S
----
S
P
R
I
M
V
A
A
H
M
D
K
I
G
V
M
V
N
H
I
D
K
D
G
Y
L
H
I
V
P
I
G
G
V
L
P
E
T
L
V
A
-----
Q
R
I
R
F
F
T
E
--
K
G
E
R
Y
G
V
V
G
V
--
L
P
P
H
L
R
---------
I
D
W
D
Q
I
------
V
-----
V
D
V
G
A
S
S
K
E
E
A
E
E
M
G
F
R
V
G
T
V
G
--
E
F
A
P
N
F
T
R
L
-
N
-
E
H
R
F
A
------
T
P
-
Y
----
L
D
D
R
I
C
L
Y
A
M
I
E
A
A
R
Q
L
G
--
D
----
H
E
A
D
I
Y
I
V
G
S
V
Q
E
E
V
G
----
L
R
G
A
R
V
A
S
Y
A
I
-
N
P
E
-
V
---
G
-
I
A
--
M
-----------
D
V
T
F
----
A
K
Q
---
P
-------
H
DKGKIV--------------------------------
P
E
L
----------------
G
K
G
--------
P
---------------------------------------------
V
M
D
V
G
------------
P
N
----
I
N
P
------
K
L
---
R
A
F
A
D
E
V
A
K
K
Y
E
I
P
L
Q
V
E
P
S
P
R
P
-
T
----
G
T
D
A
N
V
M
Q
I
N
K
E
G
V
A
T
A
V
L
S
I
P
I
R
Y
M
H
S
Q
V
E
L
A
D
-
A
R
D
V
D
N
T
I
K
L
A
K
A
L
L
E
E
L
K
P
M
10
PsiBlast_PDB
61.82
22%
-64
- C3 -
2WYR
2
?
A:
[2-327]
-
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
-
E
-
R
I
R
E
E
I
I
R
E
I
K
D
F
----
A
D
Y
K
V
D
--------
A
I
G
N
L
-
I
V
E
L
-
G
E
--
G
E
E
R
-
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
-----
R
H
V
N
V
V
T
E
K
G
I
L
D
----
G
V
I
G
A
T
P
P
H
L
------------
K
S
V
I
P
WY---
D
L
V
---
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
--
V
F
K
K
H
F
S
V
L
-
N
-
G
K
Y
V
S
------
T
R
-
G
----
L
D
D
R
F
G
V
V
A
L
I
E
--
A
I
K
D
--
L
V
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
----
L
K
G
A
K
F
L
A
N
---
H
Y
Y
P
Q
---
Y
A
F
A
--
I
-----------
D
S
F
A
C
C
SP
L
T
G
---
D
-------
V
--------------------------------------
K
L
G
----------------
K
G
P
--------
V
---------------------------------------------
I
R
A
V
-
D
N
----
S
-----
A
I
----
Y
S
R
------
D
L
---
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
-
G
--
G
----
G
T
D
A
S
A
F
Q
D
R
S
---
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
-
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
---
22
HHSearch
61.08
21%
-72
- C3 -
3ISX
3
?
A:
[12-342]
--
H
M
K
E
L
I
R
K
L
T
E
A
F
G
P
S
G
R
E
-
E
-
E
V
R
S
I
I
L
E
E
L
E
G
H
--
I
D
G
H
R
I
D
G
--------
L
G
N
L
I
-
V
W
K
G
-
S
----
G
E
K
K
V
I
L
D
A
H
I
D
E
I
G
V
V
V
T
N
V
D
D
K
G
F
L
T
I
E
P
V
G
G
V
S
P
Y
M
L
L
G
-----
K
R
I
R
F
E
N
G
-----
T
I
G
V
V
G
M
--
E
G
E
T
T
E
E
R
Q
E
N
-
V
R
K
L
S
F
D
K
L
------
F
-----
I
D
I
G
A
N
S
R
E
E
A
Q
K
-
M
C
P
I
G
S
F
G
--
V
Y
D
S
G
F
V
E
V
-
S
--
G
K
Y
V
------
S
K
-
A
----
M
D
D
R
I
G
C
A
V
I
V
E
V
F
K
R
I
K
-------
P
A
V
T
L
Y
G
V
F
S
V
Q
E
E
V
G
----
L
V
G
A
S
V
A
G
Y
GV-
P
A
D
-
E
---
A
-
I
A
--
I
-----------
D
V
T
D
----
S
A
D
---
T
PKAIKRH
A
--------------------------------------
M
R
L
----------------
S
G
G
--------
P
---------------------------------------------
A
L
K
V
K
D
R
----
A
-----
S
I
----
S
S
K
------
R
I
---
L
E
N
L
I
E
I
A
E
K
F
D
I
K
Y
Q
M
E
V
L
-
T
F
-
G
----
G
T
N
A
M
G
Y
Q
R
T
R
E
G
I
P
S
A
T
V
S
I
P
T
R
Y
V
H
S
P
S
E
M
I
A
-
P
D
D
V
E
A
T
V
D
L
L
I
R
Y
L
G
A
----
2
PsiBlast_PDB
59.95
24%
-81
- C3 -
2FVG
3
?
A:
[3-309]
------
Y
L
K
E
L
S
M
M
P
G
V
S
G
D
E
-
G
-
K
V
R
D
F
I
K
S
K
I
E
G
L
---
V
D
N
L
Y
T
D
--------
V
L
G
N
L
-
I
A
L
K
R
G
R
--
D
S
S
K
K
L
L
V
S
A
H
M
D
E
V
G
F
V
V
S
K
I
E
K
D
G
K
V
S
F
L
P
V
G
G
V
D
P
R
I
L
P
G
-----
K
V
V
Q
V
---
K
N
L
K
-----
G
V
I
G
Y
R
-------------
P
P
R
F
E
N
L
--------
R
---
I
D
F
G
F
S
S
A
D
E
A
K
K
Y
-
V
S
I
G
D
Y
V
--
S
F
-
V
S
D
Y
I
E
-
K
-
N
G
R
A
V
------
G
K
-
A
----
F
D
D
R
A
G
C
S
V
L
I
D
V
L
------
E
S
G
V
S
P
A
Y
D
T
Y
F
V
F
T
V
Q
E
E
---------
S
A
V
V
V
E
---
Q
L
K
-
P
---
T
-
C
A
I
V
V
-----------
E
T
T
T
----
A
G
D
---
N
-------
P
--------------------------------------
E
L
E
----------------
E
R
K
--------
W
---------------------------------------------
A
T
H
L
G
D
-----------
G
P
A
I
T
F
Y
H
R
GYVIP
K
E
I
---
F
Q
T
I
V
D
T
A
K
N
N
D
I
P
F
Q
M
K
R
R
-
T
------------------
Y
G
V
P
A
G
V
I
S
T
P
A
R
Y
I
H
S
-
P
N
S
I
I
-
D
L
N
D
Y
E
N
T
K
K
L
I
K
V
L
V
E
E
G
K
I
12
PsiBlast_PDB
59.83
22%
-67
- C3 -
2CF4
2
?
A:
[3-327]
--
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
-
E
-
R
I
R
E
E
I
I
R
E
I
K
D
F
----
A
D
Y
K
V
D
--------
A
I
G
N
L
-
I
V
E
L
-
G
E
--
G
E
E
R
-
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
-----
R
H
V
N
V
V
T
E
K
G
I
L
D
----
G
V
I
G
A
T
P
P
H
L
-------
S
L
E
R
D
K
S
V
I
PWY---
D
L
V
---
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
--
V
F
K
K
H
F
S
V
L
-
N
-
G
K
Y
V
S
------
T
R
-
G
----
L
D
D
R
F
G
V
V
A
L
I
E
--
A
I
K
D
--
L
V
D
H
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
----
L
K
G
A
K
F
L
A
N
---
H
Y
Y
P
Q
---
Y
A
F
A
--
I
-----------
D
S
F
A
CCSP
L
T
G
---
D
-------
V
--------------------------------------
K
L
G
----------------
K
G
P
--------
V
---------------------------------------------
I
R
A
V
-
D
N
----
S
-----
A
I
----
Y
S
R
------
D
L
---
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
-
G
--
G
----
G
T
D
A
S
A
F
Q
D
R
S
---
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
-
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
---
5
PsiBlast_PDB
59.33
24%
-77
- C3 -
1VHE
1
YSDC_BACSU
A:
[6-306]
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
-
R
-
E
V
R
Q
V
M
K
S
Y
I
E
P
F
--
A
-
D
E
V
T
T
D
--------
R
L
G
S
L
-
I
A
K
K
T
G
A
--
E
N
G
P
K
I
M
I
A
G
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
-----
Q
R
V
T
I
-
V
T
K
K
G
-
E
I
T
G
--
V
I
G
S
K
P
P
H
I
L
------
S
P
E
A
R
K
K
S
V
------
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
-
F
T
V
M
N
-
N
-
E
K
F
L
L
------
A
K
-
A
----
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
Q
--
N
T
D
--
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L---
R
G
A
K
T
A
--
A
---
H
T
I
-
Q
PD
I
A
-
F
G
--
V
-----------
D
V
G
I
----
A
G
D
---
T
-------
P
--------------------------------------
G
I
S
----------------
E
K
E
--------
A
QSKMGKGP-------------------------------------
Q
I
I
V
Y
D
A
----
S
-----
M
V
----
S
H
K
------
G
L
---
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
-
A
G
-
G
----
G
T
D
S
G
A
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
-
H
A
A
M
L
-
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
34
HHSearch
58.73
21%
-64
- C3 -
3RZA
10
?
A:
[24-393]
-
Q
R
L
L
N
T
F
L
E
L
V
Q
I
D
S
E
T
G
N
E
-
S
-
T
I
Q
P
I
L
K
E
K
F
I
A
L
--
G
L
D
V
K
E
D
E
AAKHPKLG
A
N
N
L
V
-
C
T
M
N
-
S
T
IE--
V
P
K
L
Y
L
T
S
H
M
D
T
V
V
P
-----------------
A
I
N
V
K
P
I
---------------------------------------------------------------------------------------------
V
K
-
D
-
D
G
Y
I
Y
------
S
D
G
T
TILG
A
D
D
K
A
G
L
A
A
M
L
E
V
L
Q
V
I
K
--
E
Q
Q
-
I
P
H
G
Q
I
Q
F
V
I
T
V
G
E
E
S
G
----
L
I
G
A
K
E
L
N
S
ELL
D
A
D
-
F
---
G
-
Y
A
--
I
-----------
D
A
S
A
----
D
V
G
---
T
-------
T
V
V
G
A
P
T
Q
M
L
I
S
A
K
I
I
G
K
T
A
HASTPKE
G
V
S
A
I
N
I
A
A
K
A
I
S
R
M
KLGQVDEI
T
T
A
N
IG
K
F
H
G
G
--------
S
A
TNIVAD
E
V
I
L
E
A
E
A
R
S
HD
P
E
R
I
K
T
Q
V
K
H
M
T
D
V
F
E
T
T
A
S
E
L
G
G
K
A
E
V
T
V
E
Q
S
Y
P
G
F
K
-----
I
N
----
D
N
E
------
A
V
---
V
K
I
A
Q
E
S
A
R
N
L
G
L
S
A
N
T
I
I
--
S
G
-
G
----
G
S
D
G
S
I
I
N
--
T
F
G
I
P
S
V
I
L
G
V
G
Y
E
K
I
H
T
T
N
E
R
M
P
-
I
K
S
L
N
L
L
A
S
Q
V
L
E
I
I
K
I
V
A
R
Q
4
PsiBlast_PDB
58.14
24%
-78
- C3 -
1XFO
4
TET_PYRHO
A:
[16-306]
-------
L
K
K
V
V
E
A
P
G
V
S
G
Y
E
F
L
-
G
I
R
D
V
V
I
E
E
I
K
D
Y
---
V
D
E
V
K
V
D
--------
K
L
G
N
V
-
I
A
H
K
--
K
--
G
E
G
P
K
V
M
I
A
A
H
M
D
Q
I
G
L
M
V
T
H
I
E
K
N
G
F
L
R
V
A
P
I
G
G
V
D
P
K
T
L
I
A
-----
Q
R
F
K
V
W
I
D
K
-
G
K
F
I
Y
G
V
G
A
--
S
V
P
-------------
A
P
D
W
D
-------
Q
I
F
---
I
D
I
G
A
E
S
K
E
E
A
E
D
M
G
V
K
I
G
T
V
I
--
T
W
D
G
R
L
E
R
L
-
G
-
K
H
R
F
V
------
S
I
-
A
----
F
D
D
R
I
A
V
Y
T
I
L
E
V
A
K
Q
L
K
DA
K
A
D
V
------
Y
F
V
A
T
V
Q
E
E
V
G
L---
R
G
A
R
T
S
A
F
G
---
I
E
P
-
D
---
Y
G
F
A
--
I
-----------
D
V
T
I
----
A
A
D
---
I
-------
P
--------------------------------------
G
T
P
----------------
E
H
K
QVTHLGK
G
T
---------------------------------------------
A
I
K
I
M
D
R
----
S
-----
V
I
----
C
H
P
------
T
I
---
V
R
W
L
E
E
L
A
K
K
H
E
I
P
Y
Q
L
E
I
L
-
L
G
-
G
----
G
T
D
A
G
A
I
H
L
T
K
A
G
V
P
T
G
A
L
S
V
P
A
R
Y
I
H
S
-
N
T
E
V
V
-
D
E
R
D
V
D
A
T
V
E
L
M
T
K
A
L
E
N
I
H
E
11
PsiBlast_PDB
57.14
21%
-63
- C3 -
1YLO
2
?
A:
[6-312]
----
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
S
E
-
Q
-
E
V
R
Q
I
L
L
E
E
A
A
R
L
--
Q
K
E
V
R
F
D
G
--------
L
G
S
V
L
-
I
R
L
N
-
E
S
--
T
G
P
K
V
-
M
I
C
A
H
M
D
E
V
G
F
M
V
R
S
I
S
R
E
G
A
I
D
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
-----
Q
P
V
R
I
T
T
R
E
E
C
K
-
I
P
G
--
L
L
D
-----------
G
-
D
R
Q
G
N
D
V
S
A
------
M
-
R
---
V
D
I
G
A
R
T
Y
D
E
V
M
Q
A
G
I
R
P
G
D
R
V
--
T
F
D
T
T
F
Q
V
L
-
P
-
H
Q
R
V
M
------
G
K
-
A
----
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
--
R
E
--
L
H
D
A
E
L
P
A
E
V
W
L
V
A
S
S
S
E
E
V
G
----
L
R
G
G
Q
T
A
T
R
---
A
V
S
-
P
---
D
-
V
A
--
I
V
L
D
T
A
C
W
AKNF
D
Y
G
A
----
A
N
H
---
R
-------
Q
--------------------------------------
I
G
N
----------------
G
P
M
--------
L
---------------------------------------------
V
L
S
D
K
S
L
----
I
-----
A
P
------
P
------
K
L
---
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
F
-
S
N
-
G
----
G
T
D
G
G
A
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
-
A
A
S
I
A
-
D
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
R
28
HHSearch
56.60
18%
-69
- C3 -
1VHO
4
?
A:
[5-335]
-
M
E
T
G
K
L
L
M
E
L
S
N
L
D
G
P
S
G
Y
E
-
T
-
N
V
V
S
Y
I
K
S
V
I
E
P
F
--
V
D
E
A
K
T
T
R
--------
H
G
S
L
I
-
G
Y
K
K
-
G
K
---
G
I
G
K
L
A
F
F
A
H
V
D
E
I
G
F
V
V
S
K
V
E
-
G
Q
F
A
R
L
E
P
V
--------
Y
A
-----
S
K
V
R
I
Y
T
K
N
--
G
I
E
R
G
V
I
G
M
--
L
A
P
H
L
Q
D
S
E
-
S
R
K
K
V
P
T
Y
D
E
I
------
F
-----
V
D
L
S
L
C
------
E
R
G
V
R
V
G
D
I
A
--
V
I
D
Q
T
A
F
E
T
-
N
--
G
K
V
V
------
G
K
-
A
----
L
D
N
R
A
S
C
G
V
L
V
K
V
L
E
F
L
K
--
R
Y
--
D
H
P
W
D
V
Y
V
V
F
S
V
Q
E
E
T
G
----
C
L
G
A
L
T
G
A
Y
EI-
N
P
D
-
A
---
A
-
I
V
--
M
-----------
D
V
T
F
----
A
S
E
---
P
-------
P
F
S
D
H
----------------------------------
I
E
L
----------------
G
K
G
--------
P
---------------------------------------------
V
I
G
L
G
P
------------
V
----
V
D
R
------
N
L
---
V
Q
K
I
I
E
I
A
K
K
H
N
V
S
L
Q
E
E
A
V
-
G
G
R--------
T
D
F
V
Q
L
V
R
N
G
V
R
T
S
L
I
S
I
P
L
K
Y
M
H
T
P
V
E
M
V
D
-
P
R
D
V
E
E
L
A
R
L
L
S
L
V
A
V
E
L
E
--