@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1993: (2015-12-12 )
MKAISFQNVTKSFGPKKILNNVSFDLEENMIYGFVGPNGAGKTTTIKMILGLLKFDTGFITIFGKKVNFGRTDTNQLIGYLPDVPEYYDYMTALEYLDLCSGLARSKHKLSNKELLRSVGLDDNHQKIATYSRGMKQRLGLAQALVHDPKIIICDEPTSALDPKGRQDILDIISNLRGEKTVIFSTHILSDVEKICDHVLVLTKCGIYSLEELKGKKSEENYSVRILIKVTKSEAKVLSHNYQIEKKDNEYALTLKGSKMDNKADLLAGFYQDLVSLKISPSAIEVIDNSLEELYLEVTK
Atome Classification :
(20 SA)
.........10..--.....--.20........30........40........50........60........---70.--...-----..-------..80........90........---------100---....--.----...---110.--.....---.120.---.-....-.130.......140.......150.......160.......170....-.-..--180........190.......200......---.210.......220.......230.......240.......250.......260.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKA
I
S
F
Q
N
V
T
K
SF--
G
P
K
K
I
--
L
N
NVSFDLEE
N
M
I
Y
G
F
VGPNGAGK
T
T
T
I
K
M
I
L
G
L
L
KFDT
G
F
I
T
I
F
GKKVNF---GRT--
D
T
N
-----
Q
L
-------
I
GYLPDV
P
E
Y
Y
D
Y
M
T
A
L
E
Y
L
D
L
---------
C
S
----
G
L
A
R
--
S
----
K
HK---L
S
N
K
--
E
L
L
R
S---VGLDD---
N
-
H
Q
K
I
-
A
T
Y
S
R
G
M
K
Q
R
L
G
L
A
Q
A
L
VHD
P
K
I
I
I
CDEPTSALDPK
G
R
Q
D
I
L
D
I
I
S
NL-R-GE--
K
-
T
V
I
F
S
T
H
I
L
S
D
V
E
K
I
C
D
H
V
L
V
L
T
KCGIY---
S
L
E
E
LKGKKSEEN
Y
S
V
R
I
L
I
K
VTKSE
A
K
V
LSHN
Y
Q
I
EKKDN
E
Y
A
L
T
L
KGSKMD
N
K
A
D
L
L
A
G
F
Y
Q
D
L
V
SLKIS
P
S
A
I
E
V
I
D
N
S
L
E
E
L
Y
L
EVTK
1
PsiBlast_PDB
93.39
34%
-118
- C1 -
1VPL
2
?
A:
[14-241]
-
G
A
V
V
V
K
D
L
R
K
R
I
--
G
K
K
E
I
--
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
N
V
V
E
---
E
P
H
--
E
V
R
-----
K
L
-------
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
G
I
E
Y
L
R
F
---------
V
A
----
G
F
Y
A
--
S
----
S
S
S
---
E
I
E
E
--
M
V
E
R
A
T
E
I
A
G
L
G
E
---
K
I
K
D
R
V
-
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
-
S
-
Q
E
--
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
ETG
T
V
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
E
E
V
V
K
---------------------------------------------------------------------
41
PsiBlast_CBE
85.13
31%
-125
- C1 -
1L2T
4
Y796_METJA
A:
[2-230]
---
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-----
D
L
--
D
D
D
-----
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PLIFKYR
G
A
M
S
----
G
E
E
R
--
R
----
K
R
A
---
L
-----
E
C
L
K
M
---
A
E
L
E
E
RFA
N
-
H
-
K
P
-
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
-
E
E
DG
K
-
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
---
R
E
E
K
L
R
--------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.09
32%
-120
- C1 -
2OUK
1
?
A:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
L
N
K
V
R
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
M
K
V
R
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
28
PsiBlast_CBE
84.72
32%
-115
- C1 -
2OUK
1
?
C:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
40
PsiBlast_CBE
84.52
31%
-122
- C1 -
1L2T
4
Y796_METJA
B:
[2-231]
---
I
K
L
K
N
V
T
K
T
Y
KM
G
E
E
I
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-----
D
L
--
D
D
D
-----
E
L
TKIRRDK
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PLIFKYRGA
M
S
----
G
E
E
R
--
R
----
K
R
A
---
L
-----
E
C
L
K
M
---
A
E
L
E
E
RFA
N
-
H
-
K
P
-
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
-
E
E
DG
K
-
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
---
R
E
E
K
L
R
G
F
------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.13
31%
-122
- C1 -
4U00
3
?
A:
[5-211]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
L
R
E
I
R
-----
R
E
-------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
---------
A
P
----
M
R
V
R
RW
P
----
R
E
K
---
A
E
K
K
A
L
E
L
L
E
R
---
V
G
I
L
D
---
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
---
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
------------------------------------------------------------------
4
PsiBlast_PDB
84.06
31%
-117
- C1 -
4U02
1
?
A:
[5-211]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
L
R
E
I
R
-----
R
E
-------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
---------
A
P
----
M
R
V
R
RW
P
----
R
E
K
---
A
E
K
K
A
L
E
L
L
E
R
---
V
G
I
L
D
---
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
---
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
------------------------------------------------------------------
31
PsiBlast_CBE
83.74
32%
-117
- C1 -
2OLK
1
?
C:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
7
PsiBlast_PDB
83.46
32%
-114
- C1 -
2OLK
1
?
A:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
L
N
K
V
R
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
32
PsiBlast_CBE
83.22
32%
-113
- C1 -
2OLK
2
?
B:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
62
HHSearch
83.11
33%
-113
- C1 -
1VPL
2
?
A:
[14-238]
-
G
A
V
V
V
K
D
L
R
K
R
I
--
G
K
K
E
I
--
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
N
V
V
E
---
E
P
H
--
E
V
R
-----
K
L
-------
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
G
I
E
Y
L
R
F
---------
V
A
----
G
F
Y
A
--
S
----
S
S
S
E
I
E
E
M
V
E
--
R
A
T
E
I
---
A
G
L
G
E
---
K
I
K
D
R
V
-
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
-
S
Q
E
G
--
L
-
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
---
E
T
G
T
V
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
E
E
V
V
K
------------------------------------------------------------------
30
PsiBlast_CBE
82.85
32%
-114
- C1 -
2OLK
1
?
D:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
22
PsiBlast_CBE
82.69
31%
-122
- C1 -
4U02
1
?
C:
[5-211]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
LR
E
I
R
-----
R
E
-------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
---------
A
P
----
M
R
V
R
RW
P
----
R
E
K
---
A
E
K
K
AL
E
L
L
E
R
---
V
G
I
L
D
---
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
---
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
------------------------------------------------------------------
59
HHSearch
82.53
29%
-103
* C1 *
2OLJ
4
?
A:
[22-250]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
K
A
KDT
N
L
N
--
K
V
R
-----
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
----
M
K
V
R
--
K
WP
R
E
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
---
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-------------------------------------------------------------------
21
PsiBlast_CBE
82.29
31%
-113
- C1 -
4U02
1
?
D:
[5-211]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
LR
E
I
R
-----
R
E
-------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
---------
A
P
----
M
R
V
R
RW
P
----
R
E
K
---
A
E
K
K
AL
E
L
L
E
R
---
V
G
I
L
D
---
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
---
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
------------------------------------------------------------------
10
PsiBlast_PDB
82.18
32%
-110
- C1 -
3C4J
3
?
A:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
L
N
K
V
R
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
M
K
V
R
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
27
PsiBlast_CBE
82.01
32%
-119
- C1 -
2OUK
1
?
D:
[23-242]
-
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
24
PsiBlast_CBE
81.86
32%
-114
- C1 -
3C41
3
?
K:
[1-221]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------
23
PsiBlast_CBE
81.85
31%
-118
- C1 -
4U02
1
?
B:
[5-211]
---
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
---
D
R
A
LR
E
I
R
-----
R
E
-------
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
---------
A
P
----
M
R
V
R
RW
P
----
R
E
K
---
A
E
K
K
AL
E
L
L
E
R
---
V
G
I
L
D
---
Q
-
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
-
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
---
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
------------------------------------------------------------------
25
PsiBlast_CBE
81.79
32%
-121
- C1 -
3C4J
4
?
B:
[22-242]
L
Q
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
---
K
A
K
--
D
T
N
LNKVR
E
E
-------
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---------
A
P
MKVR
K
W
P
R
--
E
----
K
A
E
---
A
K
A
M
--
E
L
L
D
K
---
V
G
L
K
D
---
K
A
H
A
Y
P
-
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
--
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
--
G
G
Y
---
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------