@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2002: (2015-12-12 )
MTTNVMANYSYGEDCFKEIPSVLATYRIQSIAFVGGKRALDSSEAEVRSILEEANIKVTGSFVYGTDSTQSNIDKLVANPQVQAADAILGFGGGKALDTAKMVAKELGKNSFTIPTICSNCSAGTAIAVVYNDDHSFLRYGYPESPLHIFINTRIIAQAPSKYFWAGIGDGISKAPEVERATLEAKTNKLPHTAVLGQAVALSSKEAFYQFGEQGLKDVEANLASRAVEEIALDILISTGYASNLVNQPDFYYNSCHAHAFYYGTTAIQRQGEFLHGVVVAFGVLVLHAYFNELEELEKVARFNKSLGLPTTLADVSLSEKDIPKIVEIAMTTNEYKNTPFDPKMFAQAILAADAFGQTLA
Atome Classification :
(20 SA)
---.........10..-......20......---..30........40--.--.......50........60........70........80..---...---...90........100....------------------.--------------------..110.......120.......130.....---..140.-..-.....150.......160.......170.......180..-.--..-..-----190-----..-....----.200.......210.....----..--------220.......230-........240-.........250.....-..260.......270-..-..-....280...---.-...290.-.--------------------------.--....--------.300...--....310....---..---.---320-.---...-.....330------.----..--------.---..----.------340-.--...--..--..350.......360-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MT
T
N
V
M
A
NYSY
G
E
-
D
C
F
K
E
I
P
S
V
L
A
T
Y
R
---
I
Q
S
I
A
FVGGKRALD--
S
--
S
E
A
E
V
R
S
I
L
E
EA
N
I
K
V
T
G
S
F
V
YGTDS
T
Q
S
N
I
D
K
L
VANPQ
V
Q
---AA
D
---
A
I
LGFGGGKA
L
D
T
A
K
M
V
A
K
E
------------------L--------------------GKNSFTI
P
T
ICSNCSAG
T
A
I
A
V
V
YNDDH
S
F
---
L
RYG-Y-PE-S
P
L
H
I
F
I
N
T
R
I
I
AQAPS
K
Y
F
W
AGIGDGISKAPE
V
E
R
A
T
L
E
-
A
--KT-NK-----LP
H
-----
T
A
-
V
LG
Q
----
A
VALS
S
K
E
A
F
Y
Q
F
G
E
Q
G
L
K
----
D
V
--------
E
A
N
L
A
S
R
A
V
E
E
I
--
A
L
D
I
L
I
STG---
Y
A
S
NLVNQPDFYYNS
C
H
-
A
H
A
F
Y
YG
T
T
A
I
Q
R-Q-
G
E
-
F
L
-
H
G
V
V
V
A
F
G
V
L
---
V
-
L
H
A
Y
-
F
N
-
E
--------------------------
L
--
E
E
L
E
--------
K
V
A
R
F
N
K
--SLGLP
T
T
L
A
DV---SL---S---E---K---D
I
P
-
K
I
V
E
I
A
M
T------T----NE--------Y---KN----T------PF--
D
--
P
K
M
--
F
A
--
Q
A
I
L
A
A
D
AFGQTLA--
7
PsiBlast_PDB
93.17
25%
-93
- C2 -
1TA9
5
GLD1_SCHPO
A:
[72-422]
-----------
Y
V
Q
G
R
-
H
A
F
T
R
S
Y
M
Y
V
K
K
W
A
---
T
K
S
A
V
V
L
A
D
Q
N
V
W
N
--
I
--
C
A
N
K
I
V
D
S
L
S
Q
N
G
M
T
V
T
-
K
L
V
F
G
G
E
A
S
L
V
E
L
D
K
L
----
R
K
Q
---
C
P
D
DTQ
V
I
I
G
V
G
G
G
K
T
M
D
S
A
K
Y
I
A
H
S
------------------
M
--------------------
N
L
P
S
I
I
C
P
T
T
A
S
S
D
A
A
T
S
S
L
S
V
I
Y
----
Q
F
---
Q
K
Y
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F
Y
-
P
L
-
N
P
N
L
I
F
I
D
T
D
V
I
V
R
A
P
V
R
F
L
I
S
G
I
G
D
A
L
S
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W
V
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V
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R
S
-
N
--
S
T
-
S
F
-----
A
G
G
-----
V
A
S
I
A
G
R
----
Y
I
A
R
A
C
K
D
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L
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A
L
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A
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L
----
S
N
--------
T
R
G
V
C
T
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A
F
E
N
V
V
E
A
N
T
L
M
S
G
L
G
---
F
E
N
G
G
L
---------
A
A
-
A
H
A
I
H
N
G
M
T
A
I
H
G
-
P
V
H
R
-
L
M
-
H
G
E
K
V
A
Y
G
T
L
V
Q
V
V
-
L
E
D
W
----
P
--------------------------
L
--
E
D
F
N
--------
N
L
A
S
F
M
A
--
K
C
H
L
P
I
T
L
E
E
L
GIP
N
V
---
T
---
D
---
E
---
E
L
L
-
M
V
G
R
A
T
L
R
------
P
----
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E
--------
S
IHN
M
S
----
K
------
K
F
--
N
--
P
S
Q
--
I
A
--
D
A
I
K
A
V
D
S
Y
S
Q
K
W
Q
--
26
HHSearch
92.97
26%
-85
- C2 -
3UHJ
2
?
A:
[26-386]
----
R
A
F
G
G
P
N
K
Y
I
Q
R
A
G
E
I
D
K
L
A
A
Y
L
A
P
L
G
----
K
R
A
L
V
L
I
D
R
V
L
F
D
--
A
--
L
S
E
R
I
------
S
-
L
-
D
I
R
F
E
R
F
G
G
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C
C
T
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R
V
R
K
V
A
I
E
H
---
G
S
D
---
I
L
V
G
V
G
G
G
K
T
A
D
T
A
K
I
V
A
I
D
------------------
T
--------------------
G
A
R
I
V
I
A
P
T
I
A
S
T
D
A
P
C
S
A
I
A
V
R
Y
T
E
H
G
V
Y
---
E
E
A
L
-
R
-
L
P
R
N
P
D
A
V
V
V
D
S
A
L
V
A
A
A
P
A
R
F
L
V
A
G
I
G
D
A
L
S
T
W
F
E
A
R
S
N
I
E
S
-
R
--
T
D
--------
N
Y
V
AG
G
F
P
A
T
-
E
A
G
M
----
A
I
A
R
H
C
Q
D
V
L
T
R
D
A
V
K
A
K
I
----
A
V
--------
E
A
G
L
L
T
P
A
V
E
N
I
--
I
E
A
N
T
L
L
S
G
---
L
G
F
E
N
C
-------
G
C
S
A
-
A
H
G
I
H
D
G
L
T
V
L
E
E
-
V
-
H
G
-
Y
F
-
H
G
E
K
V
A
F
G
T
L
---
C
-
L
L
M
L
-
E
N
R
D
--------------------------
R
--
A
E
I
E
--------
A
M
I
R
F
C
R
--
S
V
G
L
P
T
K
L
A
D
L
---
G
I
---
V
---
D
---
D
V
P
A
K
I
G
-
R
V
A
E
A
A
C
R
------
P
----
G
N
--------
I
---
I
Y
A---
T
------
P
V
TI
T
--
V
P
A
--
V
R
--
D
A
I
L
A
L
D
A
F
S
R
S
I
---
29
HHSearch
91.81
27%
-78
- C2 -
1KQ3
3
GLDA_THEMA
A:
[15-370]
----
T
T
T
I
F
P
G
R
Y
V
Q
G
A
G
A
I
N
I
L
E
E
E
L
S
R
F
G
----
E
R
A
F
V
V
I
D
D
F
V
D
K
N-
V
--
L
G
E
N
F
F
S
S
F
T
K
V
R
V
---
N
K
Q
I
F
G
G
E
C
S
D
E
E
I
E
R
L
S
G
L
-
V
E
E
---
E
T
D
---
V
V
V
G
I
G
G
G
K
T
L
D
T
A
K
A
V
A
Y
K
------------------
L
--------------------
K
K
P
V
V
I
V
P
T
I
A
S
T
D
A
P
C
S
A
L
S
V
I
Y
T
P
N
G
E
F
---
K
R
Y
L
-
F
-
L
P
R
N
P
D
V
V
L
V
D
T
E
I
V
A
K
A
P
A
R
F
L
V
A
G
M
G
D
A
L
A
T
W
F
E
A
E
S
C
K
Q
K
-
Y
--
A
---------
P
N
M
-----
T
G
-
R
L
G
S
----
M
T
A
Y
A
L
A
R
L
C
Y
E
T
L
L
E
Y
G
V
L
A
K
R
S
V
--------
E
E
K
S
V
T
P
A
L
E
K
I
--
V
E
A
N
T
L
L
S
G
---
L
G
F
E
S
G
-------
G
L
A
A
-
A
H
A
I
H
N
G
L
T
V
L
E
N
-
T
-
H
K
-
Y
L
-
H
G
E
K
V
A
I
G
V
L
---
A
-
S
L
F
L
-
T
D
-
K
P-------------------------
R
--
K
M
I
E
--------
E
V
Y
S
F
C
E
--
E
V
G
L
P
T
T
L
A
E
I
---
G
L
---
D
GVS
D
---
E
---
D
L
M
-
K
V
A
E
K
A
C
D
------
K
----
N
E
--------
T
---
I
H
N---
E
------
P
Q
PV
T
--
S
K
D
--
V
F
--
F
A
L
K
A
A
D
R
Y
G
R
M
R
K
--
25
HHSearch
91.45
24%
-80
* C2 *
1JQ5
3
GLDA_GEOSE
A:
[5-362]
----
R
V
F
I
S
P
A
K
Y
V
Q
G
K
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
----
N
K
T
V
V
I
A
D
E
I
V
W
K
--
I
--
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
-
A
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
---
E
A
A
---
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
--------------------
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
-
V
---
F
E
S
Y
R
F
-
Y
K
K
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
-
G
--
G
K
T
M
A
-----
G
G
I
-----
P
T
-
I
A
A
E
----
A
I
A
E
K
C
E
Q
T
L
F
K
Y
G
K
L
A
Y
E
----
S
V
--------
K
A
K
V
V
T
P
A
L
E
A
V
--
V
E
A
N
T
L
L
S
G
---
L
G
F
E
S
G
-------
G
L
A
A
-
A
H
A
I
H
N
G
F
T
A
L
E
G
E
I
-
H
H
-
L
T
-
H
G
E
K
V
A
F
G
T
L
---
V
-
Q
L
A
L
-
E
E
H
S
--------------------------
Q
--
Q
E
I
E
--------
R
Y
I
E
L
Y
L
--
C
L
D
L
P
V
T
L
E
D
I
---
K
L
---
K
DAS
R
---
E
---
D
I
L
-
K
V
A
K
A
A
T
A
------
E
----
G
E
--------
T
---
I
H
----
N
------
A
F
NV
T
--
A
D
D
--
V
A
--
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
--
46
Fugue
91.12
26%
-71
- C2 -
1KQ3
3
GLDA_THEMA
A:
[12-375]
HM
I
T
T
T
I
F
P
G
R
Y
V
Q
G
A
-
G
A
I
N
I
L
E
E
E
L
S
R
F
G
---
E
R
A
F
V
V
I
D
D
F
V
D
K
N
--
V
--
L
G
E
N
F
F
S
S
F
T
--
K
V
R
V
N
K
Q
I
F
G
G
-
E
C
S
D
E
E
I
E
R
L
S
G
L
V
E
E
----
E
T
D
---
V
V
V
G
I
G
G
G
K
T
L
D
T
A
K
A
V
A
Y
K
------------------
L
--------------------
K
K
P
V
V
I
V
P
T
I
A
S
T
D
A
P
C
S
A
L
S
V
I
Y
T
P
N
G
E
F
---
K
R
Y
L
-
F
L
P
R
-
N
P
D
V
V
L
V
D
T
E
I
V
A
K
A
P
A
R
F
L
V
A
G
M
G
D
A
L
A
T
W
F
E
A
E
S
C
K
Q
K
Y
A
--
P
N
-
M
T
-----
G
R
L
-----
G
S
-
M
T
A
Y
----
A
L
A
R
L
C
Y
E
T
L
L
E
Y
G
V
L
A
K
R
----
S
V
--------
E
E
K
S
V
T
P
A
L
E
K
I
--
V
E
A
N
T
L
L
S
G
---
L
G
F
E
S
G
G
L
A
-------
A
-
A
H
A
I
H
N
G
L
T
V
L
E
N
-
T
-
H
K
-
Y
L
-
H
G
E
K
V
A
I
G
V
L
---
A
-
S
L
F
L
-
T
D
K
P
--------------------------
R
--
K
M
I
E
--------
E
V
Y
S
F
C
E
--
E
V
G
L
P
T
T
L
A
E
I
---
G
L
---
D
---
G
---
V
---
S
D
E
-
D
L
M
K
V
A
E
K
A
C
DKNE
T
----
I
H
--------
N
---
E
P
----
Q
------
P
V
--
T
--
S
K
D
--
V
F
--
F
A
L
K
A
A
D
R
Y
G
R
M
R
K
NL
31
HHSearch
89.56
23%
-90
- C2 -
1TA9
5
GLD1_SCHPO
A:
[63-424]
---
D
R
I
F
T
S
P
Q
K
Y
V
Q
G
R
H
A
F
T
R
S
Y
M
Y
V
K
K
W
A
---
T
K
S
A
V
V
L
A
D
Q
N
V
W
N
--
I
--
C
A
N
K
I
V
D
S
L
S
Q
N
G
M
T
-
V
T
K
L
V
F
G
G
E
A
S
L
V
E
L
D
K
L
R
K
Q
C
P
-
D
---
D
T
Q
---
V
I
I
G
V
G
G
G
K
T
M
D
S
A
K
Y
I
A
H
S
------------------
M
--------------------
N
L
P
S
I
I
C
P
T
T
A
S
S
D
A
A
T
S
S
L
S
V
I
Y
----
Q
F
---
Q
K
Y
S
-
F
-
Y
P
L
N
P
N
L
I
F
I
D
T
D
V
I
V
R
A
P
V
R
F
L
I
S
G
I
G
D
A
L
S
T
W
V
E
T
E
S
V
I
R
S
-
N
--------------------
S
T
-
S
F
A
G
----
G
V
A
S
I
A
G
R
Y
I
A
R
A
C
K
D
T
L
E
----
K
Y
A
L
S
A
I
L
S
N
T
R
G
V
C
T
E
A
F
E
N
V
--
V
E
A
N
T
L
M
S
G
---
L
G
F
E
N
G
-------
G
L
A
A
-
A
H
A
I
H
N
G
M
T
A
I
H
G
P
V
-
H
R
-
L
M
-
H
G
E
K
V
A
Y
G
T
L
---
V
-
Q
V
V
L
-
E
D
W
P
--------------------------
L
--
E
D
F
N
--------
N
L
A
S
F
M
A
--
K
C
H
L
P
I
T
L
E
E
L
---
G
I
---
P
---
N
VT
D
E
---
E
L
L
-
M
V
G
R
A
T
L
R
------
P
----
D
E
--------
S
---
I
H
N---
M
------
S
K
K
F
N
--
P
S
Q
--
I
A
--
D
A
I
K
A
V
D
S
Y
S
Q
K
W
Q
--
45
Fugue
87.64
24%
-74
- C2 -
1JQ5
3
GLDA_GEOSE
A:
[2-367]
A
A
E
R
V
F
I
S
P
A
K
Y
V
Q
G
K
-
N
V
I
T
K
I
A
N
Y
L
E
G
I
G
----
N
K
T
V
V
I
A
D
E
I
V
W
K
--
I
--
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
E
E
V
V
F
S
G
-
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
---
E
A
A
---
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
--------------------
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
V
F
---
E
S
Y
R
F
Y
-
K
K
-
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
R
S
V
I
K
S
-
G
--
G
K
-
T
M
-----
A
G
G
-----
I
P
T
I
A
A
E
----
A
I
A
E
K
C
E
Q
T
L
F
K
Y
G
K
L
A
Y
E
----
S
V
--------
K
A
K
V
V
T
P
A
L
E
A
V
--
V
E
A
N
T
L
L
S
G
---
L
G
F
E
S
G
G
L
A
-------
A
-
A
H
A
I
H
N
G
F
T
A
L
E
G
-
E
-
I
H
H
L
T
-
H
G
E
K
V
A
F
G
T
L
---
V
-
Q
L
A
L
E
E
H
-
S
--------------------------
Q
--
Q
E
I
E
--------
R
Y
I
E
L
Y
L
--
C
L
D
L
P
V
T
L
E
D
I
---
K
L
---
K
---
D
---
A
---
S
R
E
-
D
I
L
K
V
A
K
A
------
A
----
T
A
EGETI---
H
---
N
A
----
F
------
N
V
--
T
--
A
D
D
--
V
A
--
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
E
K
1
PsiBlast_PDB
86.15
31%
-70
- C2 -
1KQ3
3
GLDA_THEMA
A:
[74-370]
-------------------------------------------------------------------------
I
F
G
G
E
C
S
D
E
E
I
E
R
L
S
G
L
V
E
-
E
---
E
T
D
---
V
V
V
G
I
G
G
G
K
T
L
D
T
A
K
A
V
A
Y
K
------------------
L
--------------------
K
K
P
V
V
I
V
P
T
I
A
S
T
D
A
P
C
S
A
L
S
V
I
Y
T
P
N
G
E
F
---
K
R
Y
L
-
F
L
P
R
-
N
P
D
V
V
L
V
D
T
E
I
V
A
K
A
P
A
R
F
L
V
A
G
M
G
D
A
L
A
T
W
F
E
A
E
S
C
K
Q
K
-
Y
--
A
P
-
N
--------
M
-----
T
G
-
R
L
G
S
M
T
A
Y
A
L
A
R
L
C
Y
E
T
L
L
E
Y
G
V
L
A
K
R
----
S
V
--------
E
E
K
S
V
T
P
A
L
E
K
I
V
E
A
N
T
L
L
S
G
L
G
---
F
E
S
G
---------
G
L
A
A
-
A
H
A
I
H
N
G
L
T
V
L
E
N
-
T
-
H
K
-
Y
L
-
H
G
E
K
V
A
I
G
V
L
---
A
S
L
F
L
T
-
D
K
-
P
--------------------------
R
--
K
M
I
E
--------
E
V
Y
S
F
C
E
--
E
V
G
L
P
T
T
L
A
E
I
---
G
L
DGV
S
---
D
---
E
---
D
L
M
-
K
V
A
E
K
A
C
D
------
K
----
N
E
--------
T
IHN
E
P
----
Q
------
P
V
--
T
--
S
K
D
--
V
F
--
F
A
L
K
A
A
D
R
Y
G
R
M
R
K
--
2
PsiBlast_PDB
86.09
31%
-68
- C2 -
3UHJ
2
?
A:
[86-386]
--------------------------------------------------------------------------
F
G
G
E
C
C
T
S
E
I
E
R
V
R
K
V
A
I
E
H
---
G
S
D
---
I
L
V
G
V
G
G
G
K
T
A
D
T
A
K
I
V
A
I
D
------------------
T
--------------------
G
A
R
I
V
I
A
P
T
I
A
S
T
D
A
P
C
S
A
I
A
V
R
Y
T
E
H
G
V
Y
E
E
A
L
R
---
L
-
P
R
-
N
P
D
A
V
V
V
D
S
A
L
V
A
A
A
P
A
R
F
L
V
A
G
I
G
D
A
L
S
T
W
F
E
A
-
R
S
N
I
E
-
S
--
R
T
-
D
N
YVAG
G
F
P
A
-----
T
E
-
A
-
G
M
----
A
I
A
R
H
C
Q
D
V
L
T
R
D
A
V
K
A
K
I
----
A
V
--------
E
A
G
L
L
T
P
A
V
E
N
I
--
I
-----------
E
A
N
T
L
L
S
G
L
G
F
E
N
C
G
C
S
A
A
H
G
I
H
D
G
L
T
V
L
E
E
-
V
-
H
G
-
Y
F
-
H
G
E
K
V
A
F
G
T
L
---
C
-
L
L
M
L
-
E
N
R
D
--------------------------
R
--
A
E
I
E
--------
A
M
I
R
F
C
R
--
S
V
G
L
P
T
K
L
A
D
L
---
G
I
---
V
---
D
-------
D
V
P
A
K
I
G
R
V
A
E
A
------
A
----
C
R
--------
P
---
G
N
IIYA
T
------
P
V
--
T
--
I
T
V
--
P
A
V
R
D
A
I
L
A
L
D
A
F
S
R
S
I
---
6
PsiBlast_PDB
84.70
29%
-80
- C2 -
4MCA
5
?
A:
[52-359]
-------------------------------------------------------------
L
Q
Q
H
G
V
K
H
H
A
A
L
F
N
G
-
E
C
C
H
K
E
I
D
R
L
G
R
E
L
K
A
H
---
G
C
R
---
G
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
I
A
H
Y
------------------
Q
--------------------
Q
L
P
V
V
L
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
Q
G
E
F
---
A
E
Y
L
I
Y
-
P
R
-
N
P
D
M
V
V
M
D
V
A
I
I
A
K
A
P
V
R
L
L
V
A
G
M
G
D
A
L
S
T
Y
F
E
A
Q
-
A
C
F
D
-
A
--
Q
A
-
T
S
-----
M
A
G
-----
G
K
-
S
T
L
A
----
A
L
S
L
-
A
R
L
C
Y
D
T
L
L
A
E
G
V
K
A
K
L
-
A
V
--------
E
A
G
V
V
T
E
A
V
E
R
I
I
E
A
N
T
Y
L
S
G
I
G
---
F
E
S
S
G
L
A
A
----------
A
H
A
I
H
N
G
F
T
V
L
E
E
-
C
-
H
H
-
L
Y
-
H
G
E
K
V
A
F
G
T
L
---
A
-
Q
L
V
L
-
Q
N
-
S
P-------------------------
M
--
A
Q
I
E
--------
T
V
L
A
F
C
H
--
R
I
G
L
P
I
T
L
A
E
M
---
G
V
---
S
---
G
---
D
---
A
V
E
-
K
I
M
A
V
A
Q
A
------
S
C
AAG
E
T
--------
I
---
H
N
----
M
------
P
F
--
K
V
T
P
A
G
--
V
Q
--
A
A
I
L
T
A
D
R
L
G
S
A
W
L
--
5
PsiBlast_PDB
82.87
29%
-72
- C2 -
1JQ5
3
GLDA_GEOSE
A:
[54-362]
-------------------------------------------------------------
L
K
K
G
N
I
A
A
E
-
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
---
E
A
A
---
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
--------------------
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
S
D
D
G
V
F
---
E
S
Y
R
F
Y
-
K
K
-
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
-
R
S
V
I
K
-
S
GG
K
T
-
M
A
-----
G
G
I
-----
P
T
-
I
A
A
E
----
A
I
A
E
K
C
E
Q
T
L
F
K
Y
G
K
L
A
Y
E
----
S
V
--------
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
---
F
E
S
G
---------
G
L
A
A
-
A
H
A
I
H
N
G
F
T
A
L
E
G
-
E
-
I
H
-
H
L
T
H
G
E
K
V
A
F
G
T
L
---
V
Q
L
A
L
E
-
E
H
-
S
--------------------------
Q
--
Q
E
I
E
--------
R
Y
I
E
L
Y
L
--
C
L
D
L
P
V
T
L
E
D
I
---
K
L
KDA
S
---
R
---
E
---
D
I
L
-
K
V
A
K
A
A
T
A
------
E
----
G
E
--------
T
---
I
H
----
N
------
A
F
--
N
--
V
T
A
D
D
V
A
--
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
--
4
PsiBlast_PDB
82.07
29%
-75
- C2 -
1JQA
3
GLDA_GEOSE
A:
[54-362]
-------------------------------------------------------------
L
K
K
G
N
I
A
A
E
-
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
---
E
A
A
---
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
--------------------
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
----
V
F
---
E
S
Y
R
F
Y
-
K
K
-
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
-
R
S
V
I
K
-
S
GG
K
T
-
M
A
-----
G
G
I
-----
P
T
-
I
A
A
E
----
A
I
A
E
K
C
E
Q
T
L
F
K
Y
G
K
L
A
Y
E
----
S
V
--------
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
---
F
E
S
G
---------
G
L
A
A
-
A
H
A
I
H
N
G
F
T
A
L
E
G
-
E
-
I
H
-
H
L
T
H
G
E
K
V
A
F
G
T
L
---
V
Q
L
A
L
E
-
E
H
-
S
--------------------------
Q
--
Q
E
I
E
--------
R
Y
I
E
L
Y
L
--
C
L
D
L
P
V
T
L
E
D
I
---
K
L
KDA
S
---
R
---
E
---
D
I
L
-
K
V
A
K
A
A
T
A
------
E
----
G
E
--------
T
---
I
H
----
N
------
A
F
--
N
--
V
T
A
D
D
V
A
--
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
--
28
HHSearch
81.79
20%
-81
- C2 -
1O2D
3
?
A:
[16-370]
------
F
Y
M
P
T
D
V
F
F
G
E
K
I
L
E
K
R
G
N
I
I
D
L
L
G
----
K
R
A
L
V
V
T
G
K
S
S
S
K
--
K
N
G
S
L
D
D
L
K
K
L
L
D
E
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
---
S
F
D
---
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
------------------
L
K
E
KDLS
V
E
D
L
Y
DREKVKH--
W
L
P
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
-
N
---
K
R
G
C
---
T
L
M
F
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
-
T
-----------------------
P
P
S
D
----
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
E
----
G
-------------
N
R
E
A
R
K
K
M
--
F
V
A
S
-
C
L
A
G
---
M
V
I
A
Q
T
-------
G
T
T
L
-
A
H
A
L
G
Y
P
L
T
T
E
K
-----
G
-
I
K
-
H
G
K
A
T
G
M
V
L
P
---
F
-
V
M
E
V
-
M
K
-
E
--------------------------
E
I
P
E
K
V
D
T
V
N
H
I
F
GG
S
L
L
K
F
L
K
--
E
L
G
L
Y
E
K
---
V
---
A
V
---
S
---
S
---
E
---
E
L
E
-
K
W
V
E
K
G
S
R
------
A
----
K
H
--------
L
---
K
N
----
T
------
P
G
TF
T
--
P
E
K
--
I
R
--
N
I
Y
R
E
A
L
G
V
-------
3
PsiBlast_PDB
81.52
29%
-73
- C2 -
1JPU
2
GLDA_GEOSE
A:
[54-362]
-------------------------------------------------------------
L
K
K
G
N
I
A
A
E
-
E
V
V
F
S
G
E
A
S
R
N
E
V
E
R
I
A
N
I
A
R
K
A
---
E
A
A
---
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
------------------
L
--------------------
D
A
Y
I
V
I
V
P
T
A
A
S
T
D
A
P
T
S
A
L
S
V
-----
G
V
F
---
E
S
Y
R
F
Y
-
K
K
-
N
P
D
L
V
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
A
T
W
V
E
A
-
R
S
V
I
K
-
S
GG
K
T
-
M
A
-----
G
G
I
-----
P
T
-
I
A
A
E
----
A
I
A
E
K
C
E
Q
T
L
F
K
Y
G
K
L
A
Y
E
----
S
V
--------
K
A
K
V
V
T
P
A
L
E
A
V
V
E
A
N
T
L
L
S
G
L
G
---
F
E
S
G
---------
G
L
A
A
-
A
H
A
I
H
N
G
F
T
A
L
E
G
-
E
-
I
H
-
H
L
T
H
G
E
K
V
A
F
G
T
L
---
V
Q
L
A
L
E
-
E
H
-
S
--------------------------
Q
--
Q
E
I
E
--------
R
Y
I
E
L
Y
L
--
C
L
D
L
P
V
T
L
E
D
I
---
K
L
KDA
S
---
R
---
E
---
D
I
L
-
K
V
A
K
A
A
T
A
------
E
----
G
E
--------
T
---
I
H
----
N
------
A
F
--
N
--
V
T
A
D
D
V
A
--
D
A
I
F
A
A
D
Q
Y
A
K
A
Y
K
--
22
HHSearch
80.29
18%
-84
- C2 -
3BFJ
1
DHAT_KLEPN
A:
[5-386]
---
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
---
G
K
K
A
L
L
V
T
D
K
G
L
R
K
D-
G
--
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
---
Q
C
D
---
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
------------------
A
T
HEGDLYQYAGIETLTNP--
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
---
K
F
V
I
V
S
-
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
-
N
-----------------------
P
V
T
D
----
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
----
L
G
--------
S
---
N
L
Q
A
R
E
Y
M
--
A
Y
A
S
-
L
L
A
G
---
M
A
F
N
N
A
-------
N
L
G
Y
-
V
H
A
M
A
H
Q
L
G
G
L
Y
-----
D
-
M
P
-
H
G
V
A
N
A
V
L
L
P
---
H
-
V
A
R
Y
-
N
L
-
I
AN
P
E
K
F
A
D
I
A
E
L
M
GENITGLS
T
L
D
A
A
E
--
K
A
I
A
--------
A
I
T
R
L
S
M
--
D
I
G
I
P
Q
H
L
R
D
L
---
G
V
---
K
---
E
---
T
---
D
F
P
-
Y
M
A
E
M
A
L
K
------
D
----
G
N
--------
A
---
F
S
----
N
------
P
R
K
G
N
--
E
Q
E
--
I
A
--
A
I
F
R
Q
A
F
---------
24
HHSearch
80.19
18%
-83
- C2 -
1RRM
4
FUCO_ECOLI
A:
[4-385]
----
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
---
Y
Q
K
A
L
I
V
T
D
K
T
L
V
Q
--
C
G-
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
---
G
A
D
---
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
------------------
S
N
N
PEFADVRSLEGLSPTNKP
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
---
K
F
V
C
V
D
-
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
-
W
-----------------------
A
L
T
D
----
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
----
G
-------------
D
K
D
A
G
E
E
M
--
A
L
G
Q
-
Y
V
A
G
---
M
G
F
S
N
V
-------
G
L
G
L
-
V
H
G
M
A
H
P
L
G
A
F
Y
-----
N
-
T
P
-
H
G
V
A
N
A
I
L
L
P
---
H
-
V
M
R
Y
-
N
A
-
D
FTGE
K
Y
R
D
I
A
R
V
M
GVKVEGMS
L
E
E
A
R
N
--
A
A
V
E
--------
A
V
F
A
L
N
R
--
D
V
G
I
P
P
H
L
R
D
V
---
G
V
---
R
---
K
---
E
---
D
I
P
-
A
L
A
Q
A
A
L
D
------
D
----
V
C
--------
T
---
G
G
----
N
------
P
R
EA
T
--
L
E
D
--
I
V
--
E
L
Y
H
T
A
W
E
G
G
------
30
HHSearch
79.54
18%
-82
- C2 -
1VLJ
2
?
A:
[16-406]
----
F
V
F
H
N
P
T
K
I
V
F
G
R
G
T
I
P
K
I
G
E
E
I
K
N
A
G
---
I
R
K
V
L
F
L
Y
G
G
G
S
I
K
K
N
G
--
V
Y
D
Q
V
V
D
S
L
K
K
H
G
I
E
W
V
E
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
---
K
V
E
---
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
------------------
A
L
YEGDIWDAFIGKYQIEK--
A
L
P
I
F
D
V
L
T
I
S
A
T
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
---
K
Y
G
V
S
S
-
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
G
S
S
-
P
-----------------------
E
I
S
N
----
E
I
A
E
G
T
I
R
T
I
M
K
M
T
E
R
L
I
E
----
K
P
-----------
D
D
Y
E
A
R
A
N
L
--
A
W
S
A
-
T
I
A
L
NGT
M
A
V
G
R
------
R
G
G
E
W
A
-
C
H
R
I
E
H
S
L
S
A
L
Y
-----
D
-
I
A
-
H
G
A
G
L
A
I
V
F
P
---
A
-
W
M
K
Y
-
V
Y
-
R
KN
P
A
Q
F
E
R
F
A
K
K
IFG
F
E
G
E
G
E
E
L
I
--
L
--
K
G
I
E
--------
A
F
K
N
W
L
K
--
K
V
G
A
P
V
S
L
K
D
A
---
G
I
---
P
---
E
---
E
---
D
I
D
-
K
I
V
D
N
V
M
L
------
L
----
V
E
K
NLKPKGA
S
---
L
G
----
R
------
I
M
V
L
E
--
R
E
D
--
V
R
--
E
I
L
K
L
A
A
K
--------
36
HHSearch
74.56
14%
-91
- C2 -
3CE9
5
?
A:
[6-321]
---
S
H
R
I
A
I
P
L
I
L
E
V
G
N
N
K
I
Y
N
I
G
Q
I
I
K
K
G
N
---
F
K
R
V
S
L
Y
F
G
E
G
I
Y
E
--
L
--
F
G
E
T
I
E
K
S
I
K
S
S
N
I
E
I
E
A
V
E
T
V
-
K
N
I
D
F
D
E
I
G
T
N
A
F
K
-
I
P
A
---
E
V
D
---
A
L
I
G
I
G
G
G
K
A
I
D
A
V
K
Y
M
A
F
L
------------------
R
--------------------
K
L
P
F
I
S
V
P
T
S
T
S
N
D
G
F
S
S
P
V
A
S
L
L
I
N
-
G
-
K
---
R
-
T
S
-
V
-
P
A
K
T
P
D
G
I
V
V
D
I
D
V
I
K
G
S
P
E
K
F
I
Y
S
-
G
I
G
D
L
V
S
N
I
T
A
L
Y
D
W
K
F
-
E
--
E
E
-
N
H
-----
K
S
I
-----
I
D
-
D
F
A
V
----
M
I
S
K
K
S
V
N
S
F
V
R
T
D
F
K
S
I
K
----
D
--------------
E
V
F
L
K
E
L
--
V
D
S
L
-
T
M
N
G
---
I
A
M
E
I
A
G
N
--
S
S
P
A
S
G
A
-
E
H
L
I
S
H
A
L
D
K
F
L
P
-
N
--
P
-
Q
L
-
H
G
I
Q
V
G
V
A
T
Y
---
I
-
M
S
K
V
-
H
K
-
H
------------------------------
R
E
E
--------
R
I
K
K
I
L
S
--
D
T
G
F
F
N
Y
V
K
G
L
---
N
M
---
K
---
K
---
S
---
D
F
K
-
R
A
I
S
E
A
H
L
------
I
----
K
P
--------
A
---
R
Y
----
T
------
Y
L
--
H
--
V
E
K
--
N
C
--
E
T
A
K
E
I
V
D
T
D
E
I
L
R
--
23
HHSearch
73.54
17%
-79
- C2 -
3OX4
2
ADH2_ZYMMO
A:
[4-382]
----
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
---
F
K
N
A
L
I
V
S
D
A
F
M
N
K
S
-
G
--
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
---
N
S
D
---
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
TNGGEVKDYEGIDKSKK
P
--------------------
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
---
K
M
A
I
V
D
-
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
-
T
-----------------------
P
I
T
D
----
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
----
N
G
-----------
K
D
M
P
A
R
E
A
M
--
A
Y
A
Q
-
F
L
A
G
---
M
A
F
N
N
A
-------
S
L
G
Y
-
V
H
A
M
A
H
Q
L
G
G
Y
Y
-----
N
-
L
P
-
H
G
V
C
N
A
V
L
L
P
---
H
-
V
L
A
Y
-
N
A
-
S
VV
A
G
R
L
K
D
V
G
V
A
M
GLDIANLG
D
K
E
G
A
E
--
A
T
I
Q
--------
A
V
R
D
L
A
A
--
S
I
G
I
P
A
N
L
T
E
L
---
G
A
---
K
---
K
---
E
---
D
V
P
-
L
L
A
D
H
A
L
K
------
D
----
A
C
--------
A
---
L
T
----
N
------
P
R
Q
G
D
--
Q
K
E
--
V
E
--
E
L
F
L
S
A
F
---------
35
HHSearch
71.12
16%
-74
- C2 -
3RF7
12
?
A:
[22-375]
---
F
K
N
F
K
C
V
P
K
M
I
F
G
R
G
S
F
V
Q
L
D
T
V
L
E
Q
E
R
TDA
N
D
F
V
V
F
L
V
D
D
V
H
Q
H
K-
P
--
L
A
A
R
V
P
N
K
A
H
D
----
L
V
I
Y
V
N
V
D
D
E
P
T
T
V
Q
V
D
E
L
T
A
Q
V
K
A
F
NTK
L
P
V
---
S
V
V
G
L
G
G
G
S
T
M
D
L
A
K
A
V
S
L
M
------------------
L
T
NPGSSSEYQGWDLIKNP--
A
V
H
H
I
G
I
P
T
V
S
G
T
G
A
E
A
S
R
T
A
V
L
C
G
P
V
--
R
---
K
L
G
L
N
S
-
D
Y
T
V
F
D
Q
I
I
M
D
S
E
L
I
A
G
V
P
T
D
Q
W
F
Y
T
G
M
D
C
F
I
H
C
V
E
S
L
Q
G
T
Y
L
-
N
-----------------------
E
F
A
K
----
A
F
A
E
K
S
M
D
L
C
R
E
V
Y
L
D
--------------------
D
H
P
E
K
D
D
K
L
--
M
M
A
S
-
Y
M
G
G
---
M
S
I
A
Y
S
-------
Q
V
G
A
-
C
H
A
V
S
Y
G
L
G
Y
V
L
-----
G
-
Y
H
-
H
G
I
G
N
C
L
A
F
D
---
V
-
L
E
E
F
-
Y
P
-
E
------------------------------
G
V
A
--------
E
F
R
K
M
M
E
I
H
N
I
T
L
P
K
N
I
C
K
----
D
L
---
P
---
D
---
E
---
T
I
A
-
K
M
V
A
V
T
K
S
------
M
----
G
P
--------
L
---
W
D
----
N
V
YGKGW
E
E
KV
T
--
D
E
M
--
L
T
--
K
L
F
R
R
I
----------