@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2004: (2015-12-12 )
MSKFLEKLKTDILVADGAMGTLLYTYGLDTCHESYNVTHPEKVLAIHQAYIEAGADVIQTNTYGAQRHRLKNYGLEDQVVSINQAAVNIAHQATLGKETFILGTVGGFRSQRQCDLTLDNIVEETLEQVEALLATGQLDGLLFETYYDIEEITTVLKIVREMTDLPIITNISLHEAGVTSNGKPIVEALSQLVMLGADVIGLNCHLGPYHMIQSLKQVPLFAQSYLSVYPNASQLSLDGENSQYQFSQNSEYFGKSAELLVAEGVRLIGGCCGTTPDHIRAVKRSIRGLKPIERKVVTPIIPVKDFVRRIRRTDTLVDKVKKEVTIIAELDPPKHLDIVQFQKAIRAIDQKGIAAITLADNSLSNTRICNLSIASLLKDEISTPFLLHIACRDHNLIGLQSRLLGMELLGFNHILAITGDPTKLGDFPGATSVYDVTSFKLLSLIKQLNQGLSYSGASLRRPTDFTVAAAFNPNVKNLTRTVKLIEKKVASGADYFMTQPIFDHSVLKELADLTKTVEQPFFIGIMPITSYNNAVFLHNEVPGIKLSESFLSALEKVKDDKEACLTLALNESKSLIDEALNYFNGIYLITPFLRYDLTLELIDYIQKKQVRKSS
Atome Classification :
(20 SA)
--.........10.-........20.......---.30.-----------------.......40........50........60........70........80--........90...------.....100....--...110.----------.----------.....120...---....130.......140.......150.......160-.-.-----..------.-..170.......180.......190.......-200.......210....-----------...220---..-----.....230.-.....------.240---------.-----.....--------..250.......260..-.....270.......280....---...290.......300........310.......320.......330.----------....-..-340.......350..--.....360.......370.......380.......390.......400.......410.......420.......-430.......440.......450.......460.......470-----....----...480.......490.......500.......510...--....520.......530.......540.--......550.......560.......570.---....-..580........590.......600.......610..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
S
K
F
L
E
K
L
K
T-
D
-
I
L
V
ADGAM
G
T
L
L
Y
T
YGL---
D
T
C
H
-----------------ESYNVT
H
P
E
K
V
L
A
I
H
Q
A
Y
I
E
AGA
D
V
I
QTNTY
G
A
Q
R
H
R
L
KNYGLED
Q
V
V
S
--
I
N
Q
A
A
V
N
I
A
H
QAT------LGK
E
T
F
I
L
G
TVG--GFRSQRQ----------C----------D
L
T
L
D
N
I
V
E
E
T
---
L
E
Q
V
E
A
L
L
ATGQLDG
L
L
F
E
T
YY
D
I
E
E
I
T
T
V
L
K
I
V
R
E
M-T-D-----L
P
------
I
-
I
T
N
I
S
L
H
EAGVTSNG
K
P
I
V
E
A
L
S
Q
L
V
M
LGA
D
V
-
I
G
LNCHL
G
P
Y
H
M
I
Q
S
L
K
-----------QV
P
L
F
A
---
Q
S
-----
Y
L
S
VYPN
A
S
-
Q
L
S
LD------GEN----------S-----
Q
Y
Q
FS--------QNSEYFGKS
A
E
L
L
V
A
E
G
-
V
R
L
I
G
GCCGT
T
P
D
H
I
R
A
V
K
R
S
I---RGLKP
I
E
R
KVVTPI-I
P
V
K
D
F
V
R
R
I
R
R
T
D
T
L
V
D
K
V
K
K
E
V
T
I
I
A
ELDPP----------KH
L
D
-
I
V
-
Q
F
Q
K
A
I
R
A
I
D
QKG
I
A
--
A
I
T
LADNSLSN
T
R
I
C
N
L
S
I
A
S
L
L
K
D
EIST
P
F
L
L
H
I
A
CRDHN
L
I
G
L
Q
S
R
L
L
G
M
E
L
LGF
N
H
I
L
A
ITGDPTKLGDFPG-ATS
V
Y
D
V
T
S
F
K
L
L
S
L
I
K
Q
L
NQGLSYSGASLRRPT
D
F
T
V
A
A
AFN-----P
N
V
K
----
N
L
T
R
T
V
K
L
I
E
K
K
VASGAD
Y
F
M
TQPIF
D
H
S
V
L
K
E
L
A
D
L
T
K
--
T
VEQ
P
F
F
I
G
I
M
P
ITSYN
N
A
V
F
L
HNEVPG--
I
K
L
S
E
S
F
L
S
A
L
E
K
VKD
D
K
E
A
C
L
T
L
ALN
E
S
K
---
S
L
I
D
-
E
A
L
N
-YFN
G
I
Y
L
IT
P
F
L
RY
D
L
T
L
E
L
I
D
Y
I
Q
K
K
Q
VRKSS
47
Fugue
79.63
22%
-56
- C3 -
4CCZ
1
METH_HUMAN
A:
[4-638]
T
L
R
D
E
I
N
A
I
L
Q
K
-
R
-
I
M
V
L
D
G
G
M
G
T
M
I
Q
R
E
K
L
---
E
E
H
F
RGQEFKDHARPLKGNN-
D
I
L
S
I
T
Q
P
D
V
I
Y
Q
I
H
K
E
Y
L
L
A
--
D
I
I
E
T
N
T
F
S
S
T
S
I
A
Q
A
D
Y
G
L
E
H
L
A
Y
R
--
M
N
M
C
S
A
G
V
A
R
K
A
A
E
E
V
T
L
Q
T
G
I
K
R
F
V
A
G
A
L
G
--
P
T
N
K
T
L
S
VSPSVERPDY
R
----------
N
I
T
F
D
E
L
V
E
A
Y
---
Q
E
Q
A
K
G
L
L
D
G
G
-
V
D
I
L
L
I
E
T
I
F
D
T
A
N
A
K
A
A
L
F
A
L
Q
N
L
-
F
-
E
-----
E
K
YAP
R
P
I
F
-
I
S
G
T
I
V
D
K
S
G
R
T
L
S
G
Q
T
G
E
G
F
V
I
S
V
S
H
G
E
P
L
C
-
I
G
L
N
C
A
L
G
A
A
E
M
R
P
F
I
E
-----------
I
I
G
K
C
T
---
T
A
-----
Y
V
L
C
Y
P
N
A
G
--
F
A
M
D
------
G
L
------------------------------------------------
V
N
I
V
G
G
C
C
G
S
T
P
D
H
I
R
E
I
A
E
A
V
---
K
N
C
K
P
----
R
V
P
P
A
-
T
A
F
E
G
H
M
L
L
S
G
L
E
P
F
R
I
G
P
Y
T
N
F
V
N
I
G
E
R
C
N
V
A
-------------
G
-
S
R
-
K
F
A
K
L
I
M
A
-
G
N
Y
E
E
A
--
L
C
V
A
K
V
Q
V
E
M
G
A
Q
V
L
D
V
N
M
D
D
G
M
L
D
------
G
P
S
A
M
T
R
F
C
N
L
I
A
S
E
P
D
I
A
K
V
P
L
C
I
D
S
S
N
F
A
V
I
E
A
G
L
K
C
C
Q
--
G
-
K
C
I
V
N
S
I
S
-------
L
K
E
G
E
D
D
F
L
E
K
A
R
K
I
K
K
Y
G
A
A
M
V
V
M
A
F
D
EEGQA
T
E
T
D
----
T
K
I
R
V
C
T
R
A
Y
H
L
L
V
K
K
L
G
F
N
P
N
D
I
I
F
D
P
N
I
L
T
--
I
G
T
G
M
--
E
E
H
N
L
Y
A
I
N
F
I
H
A
T
K
V
I
K
E
T
L
P
G
A
R
I
S
G
GL
S
N
L
S
F
S
F
-
R
G
M
E
A
I
R
E
A
M
H
G
V
F
L
Y
H
A
I
K
S
G
MDM
G
I
V
N
A
G
N
L
P
-
V
Y
D
D
I
H
K
E
L
L
Q
L
C
E
D
L
I
W
N
K
D
P
E
A
T
E
K
L
L
R
Y
A
Q
24
HHSearch
75.74
29%
-86
* C3 *
1Q7Z
1
?
A:
[6-361]
----
E
V
S
K
L
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
A
--------
G
E
K
L
V
F
G
D
I
G
--
P
T
G
E
L
P
Y
PL--------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
-
E
G
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
S
R
-
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
E
--------
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
A
V
S
S
P
S
K
L
V
T
F
-----------
D
H
F
V
V
I
G
E
R
I
N
P
AGR
K
K
L
W
A
E
M
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
-------------------------------------------------------------
12
PsiBlast_PDB
73.84
26%
-80
- C3 -
1UMY
2
BHMT1_RAT
A:
[14-322]
------
L
E
R
L
N
A
G
E
-
V
V
I
G
D
G
G
F
V
F
A
L
E
K
R
G
Y
VKA
G
P
W
T
-----------------
P
E
A
A
V
E
H
P
E
A
V
R
Q
L
H
R
E
F
L
R
A
G
S
N
V
M
Q
T
F
T
F
Y
A
S
-------------
S
G
Q
K
V
N
E
A
A
C
D
I
A
R
Q
V
A
------
D
E
G
D
A
L
V
A
G
G
V
S
--
Q
T
P
S
Y
L
S
----------
C
KS--------
E
T
E
V
K
K
I
F
H
Q
Q
---
L
E
----
V
F
M
K
K
N
V
D
F
L
I
A
E
Y
F
E
H
V
E
E
A
V
W
A
V
E
A
L
K
-
T
-
S
-
G
-----
K
P
------
I
-
A
A
T
M
C
I
G
P
E
G
D
L
H
G
V
S
P
-
G
E
C
A
V
R
L
V
K
A
G
A
A
I
-
V
G
V
N
C
H
F
D
P
S
T
S
L
Q
T
I
K
L
M
---------
K
E
G
L
E
A
A
R
L
K
A
-----
Y
L
M
S
Q
P
L
A
Y
-
H
T
P
D
C
------
G
K
Q
----------
G
FIDLP
E
F
P
F
G
LEPRVAT
R
W
D
I
Q
K
Y
A
R
E
A
Y
N
L
---
G
-
V
R
Y
I
G
G
C
C
G
F
E
P
Y
H
I
R
A
I
A
E
E
L
A
PE
R
G
F
L
P
P
A
S
E
K
H
G
S
W
-
G
S
G
L
D
M
H
T
K
P
W
I
R
A
R
A
R
K
E
Y
W
Q
N
L
R
I
A
S
G
R
P
Y
N
----------
P
S
M
S
-
K
P
-
D
A
W
G
V
T
K
G
A
A
E
L
M
Q
Q
--
K
E
A
T
T
E
Q
Q
L
R
A
L
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
73.31
32%
-94
- C3 -
1Q8J
2
?
B:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
----------------------------------
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
P
G
V
L
P
L
G
-----
A
E
G
K
----
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
P
D
R
S
Y
Y
N
T
A
F
L
V
L
--
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
M
K
T
L
N
A
T
L
V
I
--
L
E
K
K
------------------------------------------------------------------------
6
PsiBlast_PDB
73.00
32%
-91
- C3 -
3BOL
3
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
L
P
D
R
S
--
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
M
--
K
T
L
N
A
T
L
V
I
L
E
K
K
---------------------------------------------------------------
45
Fugue
72.99
23%
-63
- C3 -
1LT8
5
BHMT1_HUMAN
A:
[11-371]
---
K
G
I
L
E
R
L
N
A
-
G
E
I
V
I
G
D
G
G
F
V
F
A
L
E
K
R
G
Y
VKA
G
P
W
T
-----------------
P
E
A
A
V
E
H
P
E
A
V
R
Q
L
H
R
E
F
L
R
A
G
S
N
V
M
Q
T
F
T
F
Y
---------
A
S
E
D
K
G
Q
E
--
V
N
E
A
A
A
D
I
A
R
Q
V
A
------
D
E
G
D
A
L
V
A
G
G
V
S
--
Q
T
P
S
Y
L
S
---------------------
A
K
S
E
T
E
V
K
K
V
F
---
L
Q
Q
L
E
V
F
M
K
K
N
-
V
D
F
L
I
A
E
Y
F
E
H
V
E
E
A
V
W
A
V
E
T
L
I
A
S
---
G
-----
K
P
------
V
-
A
A
T
M
A
I
G
P
E
G
-
D
L
H
G
V
P
P
G
E
A
A
V
R
L
V
K
A
G
A
S
I
-
I
G
V
N
C
H
F
D
P
T
I
S
L
K
T
V
K
-----------
L
M
K
E
G
L
---
E
A
A
Q
L
K
A
H
L
M
S
Q
P
L
A
Y
-
H
T
P
D
A
------
N
K
Q
GFIDLPEFPF
G
-----
L
E
P
R
V
--------
A
T
R
W
D
I
Q
K
Y
A
R
E
A
Y
N
L
G
-
V
R
Y
I
G
G
C
C
G
F
E
P
Y
H
I
R
A
I
A
E
E
L
---
A
P
E
R
G
------
F
L
P
-
P
A
S
E
K
H
G
S
W
G
S
G
L
D
M
H
T
K
P
W
V
R
A
R
A
R
K
E
Y
W
E
N
L
----------
R
I
A
S
-
G
R
-
P
Y
N
P
S
M
S
K
P
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.96
32%
-94
- C3 -
3BOL
4
?
B:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
----------------------------------
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
L
P
D
R
S
--
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
M
--
K
T
L
N
A
T
L
V
I
L
E
K
K
E
L
-------------------------------------------------------------
4
PsiBlast_PDB
72.89
32%
-94
- C3 -
1Q8J
2
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
-------------------------------------------------------------
5
PsiBlast_PDB
72.85
32%
-92
- C3 -
3BOF
3
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
L
------------------------------------------------------------
10
PsiBlast_PDB
72.17
27%
-78
- C3 -
1LT7
1
BHMT1_HUMAN
A:
[14-322]
------
L
E
R
L
N
A
G
E
-
I
V
I
G
D
G
G
F
V
F
A
L
E
K
R
G
Y
------------------------------
H
P
E
A
V
R
Q
L
H
R
E
F
L
R
A
G
S
N
V
M
Q
T
F
T
---------------------
V
N
E
A
A
A
D
I
A
R
Q
V
A
------
D
E
G
D
A
L
V
A
G
G
V
------
S
Q
T
P
----------
S
----------
Y
L
S
A
K
S
E
T
E
V
K
K
V
F
L
Q
Q
L
E
V
F
M
K
K
-
N
V
D
F
L
I
A
E
Y
F
E
H
V
E
E
A
V
W
A
V
E
T
L
I
-
A
-
S
-
G
-----
K
P
------
V
-
A
A
T
M
A
I
G
P
E
G
-
D
L
H
G
V
P
P
G
E
A
A
V
R
L
V
K
A
G
A
S
I
-
I
G
V
N
C
H
F
D
P
T
I
S
L
K
T
V
K
L
M
K
E
G
L
E
A
A
Q
L
K
A
H
L
M
S
---
Q
P
-----
L
A
Y
H
T
P
D
A
N
K
Q
G
F
I
D
LPEFPF
G
L
E
----------
P
-----
R
V
A
T
R
--------
W
D
I
Q
K
Y
A
R
E
A
Y
N
L
---
G
-
V
R
Y
I
G
G
C
C
G
F
E
P
Y
H
I
R
A
I
A
E
E
L
A
PE
R
G
F
L
P
P
R
A
R
A
R
K
E
Y
-
W
E
N
L
R
I
A
S
G
R
P
Y
N
P
S
M
S
K
P
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.08
32%
-90
- C3 -
1Q7M
-
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
-------------------------------------------------------------
8
PsiBlast_PDB
72.05
32%
-91
- C3 -
1Q8A
2
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
-------------------------------------------------------------
2
PsiBlast_PDB
71.69
32%
-90
- C3 -
1Q7Q
-
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
L
P
R
A
E
V
-------------------------------------------------------
3
PsiBlast_PDB
71.42
32%
-90
- C3 -
1Q7Z
1
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
-------------------------------------------------------------
11
PsiBlast_PDB
71.27
27%
-69
- C3 -
1LT8
3
BHMT1_HUMAN
A:
[14-322]
------
L
E
R
L
N
A
G
E
-
I
V
I
G
D
G
G
F
V
F
A
L
E
K
R
G
Y
VKA
G
P
W
T
-----------------
P
E
A
A
V
E
H
P
E
A
V
R
Q
L
H
R
E
F
L
R
A
G
S
N
V
M
Q
T
F
T
F
Y
A
S
E
D
K
---------
G
Q
E
--
V
N
E
A
A
A
D
I
A
R
Q
V
A
------
D
E
G
D
A
L
V
A
G
G
V
------
S
Q
T
P
----------
S
----------
Y
L
S
A
K
S
E
T
E
V
K
K
V
F
L
Q
Q
L
E
V
F
M
K
K
-
N
V
D
F
L
I
A
E
Y
F
E
H
V
E
E
A
V
W
A
V
E
T
L
I
-
A
-
S
-
G
-----
K
P
------
V
-
A
A
T
M
A
I
G
P
E
G
-
D
L
H
G
V
P
P
G
E
A
A
V
R
L
V
K
A
G
A
S
I
-
I
G
V
N
C
H
F
D
P
T
I
S
L
K
T
V
K
L
M
K
E
G
L
E
A
A
Q
L
K
A
H
L
M
S
---
Q
P
-----
L
A
Y
H
T
P
D
A
N
K
Q
G
F
I
D
LPEFPF
G
L
E
----------
P
-----
R
V
A
T
R
--------
W
D
I
Q
K
Y
A
R
E
A
Y
N
L
---
G
-
V
R
Y
I
G
G
C
C
G
F
E
P
Y
H
I
R
A
I
A
E
E
L
A
PE
R
G
F
L
P
P
A
S
E
K
H
G
S
W
-
G
S
G
L
D
M
H
T
K
P
W
V
R
A
R
A
R
K
E
Y
W
E
N
L
R
I
A
S
G
R
P
Y
N
----------
P
S
M
S
-
K
P
-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.13
32%
-91
- C3 -
1Q7Z
1
?
B:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------------------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
P
G
V
L
P
-----
L
G
A
E
----
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
P
D
R
S
Y
Y
N
T
A
F
L
--
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
M
K
T
L
N
A
T
L
--
V
I
L
E
K
K
----------------------------------------------------------------------
7
PsiBlast_PDB
70.54
32%
-91
- C3 -
1Q85
2
?
A:
[11-296]
---------
L
S
E
-
R
-
V
L
L
L
D
G
A
Y
G
T
E
F
M
K
Y
G
Y
---
D
D
L
P
-----------------
E
E
L
N
I
K
A
P
D
V
V
L
K
V
H
R
S
Y
I
E
S
G
S
D
V
I
L
T
N
T
F
G
A
T
R
M
K
L
R
K
H
G
L
E
D
K
L
D
P
--
I
V
R
N
A
V
R
I
A
R
R
A
--------
A
G
E
K
L
V
F
G
D
I
G
P
T
G
E
L
P
Y
P
L
----------
G
----------
S
T
L
F
E
E
F
Y
E
N
F
---
R
E
T
V
E
I
M
V
E
E
G
-
V
D
G
I
I
F
E
T
F
S
D
I
L
E
L
K
A
A
V
L
A
A
R
E
V
-
S
R
D
-----
V
F
------
L
-
I
A
H
M
T
F
D
E
K
G
R
S
L
T
G
T
D
P
A
N
F
A
I
T
F
D
E
L
D
I
D
A
-
L
G
I
N
C
S
L
G
P
E
E
I
L
P
I
F
Q
-----------
E
L
S
Q
Y
T
---
D
K
-----
F
L
V
V
E
P
N
A
G
-
K
P
I
V
--------
E
N
----------
G
-----
K
T
V
Y
P
--------
L
K
P
H
D
F
A
V
H
I
D
S
Y
Y
E
L
G
-
V
N
I
F
G
G
C
C
G
T
T
P
E
H
V
K
L
F
R
K
V
L
---
G
N
R
K
P
L
Q
R
K
K
K
R
I
F
-
A
V
S
S
P
S
K
L
V
T
F
D
H
F
V
V
I
G
E
R
I
N
P
A
G
R
K
K
L
W
A
E
M
----------
Q
K
G
N
-
E
E
-
I
V
I
K
E
A
K
T
Q
V
E
K
G
A
E
--
V
L
D
V
N
F
G
I
E
S
Q
I
D
V
R
Y
V
E
K
I
V
Q
T
L
P
Y
V
S
N
V
P
L
S
L
D
I
Q
N
V
D
L
T
E
R
A
L
R
A
Y
P
G
R
S
L
F
N
S
A
K
V
D
E
E
E
L
E
M
K
I
N
L
L
K
K
Y
-
G
G
T
L
I
V
L
L
M
G
K
D
V
P
K
S
F
E
E
R
K
E
Y
F
E
K
A
L
K
I
L
E
R
H
D
F
S
D
R
V
I
F
D
-----
P
G
V
L
----
P
L
G
A
E
G
K
P
V
E
V
L
K
T
I
E
F
I
S
S
K
G
F
N
T
T
V
G
L
S
N
L
S
F
G
L
P
D
R
--
S
Y
Y
N
T
A
F
L
V
L
G
I
S
K
G
L
S
S
A
I
M
N
P
L
D
E
T
L
--
M
K
T
L
N
A
T
L
V
I
L
E
K
K
E
-------------------------------------------------------------
25
HHSearch
68.37
20%
-111
- C3 -
3APT
1
?
A:
[10-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
G
P
L
F
S
F
E
F
F
P
P
----------
K
D
P
E
G
E
E
-
A
L
F
R
T
L
E
E
L
K
A
F
R
P
A
--
F
V
S
I
T
Y
G
A
M
G
S
T
R
E
R
S
V
A
W
A
Q
R
I
Q
S
-
L
G
L
N
P
L
A
H
L
T
V
A
G
Q
S
R
K
E
V
A
E
V
L
H
R
F
V
E
S
G
V
E
N
L
L
A
L
R
G
D
P
P
R
G
E
R
V
F
R
P
H
P
E
G
F
R
-
Y
A
A
E
L
V
A
L
I
R
E
R
Y
------------
G
D
R
V
S
V
G
G
A
A
Y
-----
P
E
G
H
PESE
S
L
E
A
D
L
R
H
F
K
A
K
V
E
A
G
L
D
F
A
I
T
Q
L
F
F
N
N
A
H
Y
F
G
F
L
E
R
A
R
R
A
G
I
G
I
P
I
L
P
G
I
M
P
V
T
S
Y
R
Q
L
R
R
F
T
-
E
V
C
G
--
A
S
I
P
G
P
L
L
A
K
L
E
R
H
Q
D
D
P
K
A
V
L
E
I
G
V
E
H
A
V
---
R
Q
V
A
-
E
L
L
E
A
G
V
E
G
V
H
F
Y
T
-
L
N
K
S
P
A
T
R
M
V
L
E
R
L
G
L
R
P
A
----
9
PsiBlast_PDB
67.84
27%
-90
- C3 -
4CCZ
-
METH_HUMAN
A:
[13-330]
---------
L
Q
K
-
R
-
I
M
V
L
D
G
G
M
G
T
M
I
Q
R
E
K
L
----
E
E
H
FRGQEFKDHARPLKGNN
D
I
L
S
I
T
Q
P
D
V
I
Y
Q
I
H
K
E
Y
L
L
A
--
D
I
I
E
T
N
T
F
S
S
T
S
I
A
Q
A
D
Y
G
L
E
H
L
A
Y
R
--
M
N
M
C
S
A
G
V
A
R
K
A
A
E
E
V
T
L
Q
T
G
I
K
R
F
V
A
G
A
L
G
--
P
T
N
K
T
L
S
----------
V
SPSVERPDYR
N
I
T
F
D
E
L
V
E
A
Y
---
Q
E
Q
A
K
G
L
L
-
D
G
G
V
D
I
L
L
I
E
T
I
F
D
T
A
N
A
K
A
A
L
F
A
L
Q
N
L
-
F
-
E
EKYAP
R
P
------
I
F
I
S
G
T
I
V
D
K
S
G
R
T
L
S
G
Q
-
T
G
E
G
F
V
I
S
V
S
H
G
E
P
L
C
I
G
L
N
C
A
L
G
A
A
E
M
R
P
F
I
E
-----------
I
I
G
K
C
T
---
T
A
-----
Y
V
L
C
Y
P
N
A
G
--------------------------------------------------------
F
A
M
D
G
L
V
N
I
V
G
G
C
C
G
S
T
P
D
H
I
R
E
I
A
E
A
V
---
K
N
C
K
P
R
V
P
P
A
T
A
F
E
-
G
H
M
L
L
S
G
L
E
P
F
R
I
G
P
Y
T
N
F
V
N
I
G
E
R
C
N
V
A
G
S
R
K
----------
F
A
K
L
-
I
M
-
A
G
N
Y
E
E
A
L
C
V
A
K
V
Q
V
--
E
M
G
A
Q
V
L
D
V
N
M
D
D
G
M
L
D
G
P
S
A
M
T
R
F
C
N
L
I
A
S
E
P
D
I
A
K
V
P
L
C
I
D
S
S
N
F
A
V
I
E
A
G
L
K
C
C
Q
G
K
C
I
V
N
S
I
S
L
K
E
G
E
D
D
F
-
L
E
K
A
R
K
I
K
K
Y
G
A
A
M
V
V
M
A
F
D
E
E
G
Q
A
T
E
T
D
T
K
I
R
V
C
T
R
A
Y
H
L
L
V
-----
K
K
L
G
----
F
N
P
N
D
I
I
F
D
P
N
I
L
T
I
G
T
G
M
E
E
H
N
L
Y
A
I
N
F
I
H
A
T
K
V
I
K
E
T
--
L
P
G
A
R
I
S
G
G
L
S
N
L
S
F
S
F
R
G
M
E
A
I
R
E
A
M
H
--
G
V
F
L
Y
H
A
I
K
S
G
M
D
M
G
I
V
N
A
G
N
L
P
V
Y
D
D
I
H
K
---
E
L
L
Q
-
L
C
E
D
-
L
I
W
N
K
D
P
E
A
T
E
K
L
L
R
Y
A
Q
---------------
26
HHSearch
66.53
19%
-129
- C3 -
3FST
1
METF_ECOLI
A:
[16-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
E
V
Q
G
Q
I
N
V
S
F
E
F
F
P
P
----------
R
T
S
E
-
M
E
Q
T
L
W
N
S
I
D
R
L
S
S
L
K
P
K
F
V
S
V
T
Y
G
A
N
S
G
E
R
D
R
T
--
H
S
I
I
K
G
I
K
D
R
T
G
L
E
A
A
P
H
L
T
C
I
D
A
T
P
D
E
L
R
T
I
A
R
D
Y
W
N
N
G
I
R
H
I
V
A
L
R
G
D
L
P
------------
E
-
M
Y
A
S
D
L
V
T
L
L
K
E
V
--------------
A
D
F
D
I
S
V
A
A
Y
-----
P
E
V
H
PEAK
S
A
Q
A
D
L
L
N
L
K
R
K
V
D
A
G
A
N
R
A
I
T
Q
F
F
F
D
V
E
S
Y
L
R
F
R
D
R
C
V
S
A
G
I
D
V
E
I
I
P
G
I
L
P
V
S
N
F
K
Q
A
K
K
L
A
-
D
M
T
N
--
V
R
I
P
A
W
M
A
Q
M
F
D
G
L
D
D
D
A
E
T
R
K
L
V
G
A
N
I
A
M
---
D
M
V
K
-
I
L
S
R
E
G
V
K
D
F
H
F
Y
T
-
L
N
R
A
E
M
S
Y
A
I
C
H
T
L
G
V
R
P
-----