@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2021: (2015-12-12 )
MIPRKIRHFLRVKKHVLINNEFINWQTVVQENDTITLIFDDEDYPTKKIPLGRAELIDCLYEDEHLIIVNKPEGMKTHGNQPNEIALLNHVSAYSGQTCYVVHRLDMETSGAVLFAKNPFILPLINQRLERKEIWREYWALVEGKFSPKHQVLRDKIGRNRHDRRKRIIDSKNGQHAMTIIDVLKYIQNSSLIKCRLETGRTHQIRVHLSHHGHPLIGDPLYNPSSNNERLMLHAHRLTLSHPLTCETISVEAPSSTFEKILNNYKKGVG
Atome Classification :
(20 SA)
-----------------------------.........10......----..20...-.....30........40........50........-60.......-.70.......---.80...--.--....90.....-----..--.100-........110..-.....120.......130.......140.......150-....---....160.......-170--.....-----...180---..---....-.-..190.......200......-.210.......220-.----------..---------------.----------.---------------..----------230.......240.......250..-.-....260.......270------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------MI
P
R
K
I
R
H
F
L
R
V
K
K
H
V
L
----INNEFI
N
-
W
Q
T
V
V
QEN
D
T
I
T
L
I
FDDEDYPTKKIPL
G
R
A
E
L
I
D
C
-LYEDE
H
L
I
I
-
V
NKPEGMKTH---GNQP
N
E
--
I
--
A
L
L
N
H
V
S
AYSG-----
Q
T
--
C
Y
V
--
V
H
R
LDMETS
G
A
V
L
-FAKN
P
F
I
L
P
L
I
N
Q
R
L
E
R
K
E
I
W
R
E
Y
W
A
L
VEGKFS
P
K
H
-
Q
-
V
L
R
D
---
K
IGR
N
R
H
D
R
R
K
R
II-D-S--KNGQ
H
-----
A
M
T
I
-----
I
D
---
V
L
K
Y
-
I
-QNS
S
L
I
K
C
R
LETG
R
T
H
Q
I
R
V
H
-LSHHGHPLIGDPLY-N----------PS---------------S----------N---------------N
E
----------
R
L
M
L
H
A
H
R
LTLSHPL
T
C
E
T
I
S
VEA
P
-
S
-
S
T
F
E
K
I
L
N
N
Y
KKGVG--------
42
Fugue
96.36
29%
-94
- C6 -
2IST
3
RLUD_ECOLI
A:
[1-324]
A
Q
R
V
Q
L
T
A
T
V
S
ENQLGQR
L
D
Q
A
L
A
E
M
F
PD
Y
S
R
S
R
I
K
E
W
I
L
D
Q
R
V
L
V
----
N
G
K
V
C
D
K
-
P
K
E
K
V
L
G
G
E
Q
V
A
I
N
A
E
I
E
R
F
E
P
Q
D
I
P
L
------
D
I
-
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
PGA
G
N
P
D
G
T
--
V
L
N
A
L
L
H
Y
Y
P
P
I
A
D
V----
P
R
--
A
G
I
--
V
H
R
L
D
K
D
T
T
G
L
M
V
-
V
A
K
T
V
P
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
G
G
-
T
-
V
D
-
E
---
P
I
S
R
H
P
T
K
R
T
H
M
A
V
---
H
--
P
M
G
K
P
-----
A
V
T
H
-----
Y
R
---
I
M
E
H
-
F
-
R
V
H
T
R
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
-
G
----------
G
R
P
R
P
P
K
GAS
E
A
F
I
S
T
L
R
----------
K
---------------
F
D
----------
R
Q
A
L
H
A
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
W
H
A
P
I
P
-
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
E
E
H
KDEVDW
4
PsiBlast_PDB
91.55
33%
-99
- C6 -
2IST
2
RLUD_ECOLI
A:
[83-299]
------------------------------------------------------------------------------------------
L
D
I
-
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
PGA
G
N
P
D
G
T
--
V
L
N
A
L
L
H
Y
Y
P
P
I
A
D
V----
P
R
--
A
G
I
--
V
H
R
L
D
K
D
T
T
G
L
M
V
-
V
A
K
T
V
P
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
G
G
-
T
-
V
--
D
---
E
P
I
S
R
H
P
T
K
R
T
H
M
A
-
V
-
H
--
P
M
G
K
P
-----
A
V
T
H
-----
Y
R
---
I
M
E
H
-
F
-
R
V
H
T
R
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
-
G
GR
P
R
P
-----
P
K
---------------
G
----------
A
---------------
S
E
A
F
I
S
T
L
R
K
FD
R
Q
A
L
H
A
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
W
H
A
P
-
I
-
P
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
--------
3
PsiBlast_PDB
91.40
33%
-99
- C6 -
1V9F
1
RLUD_ECOLI
A:
[83-299]
------------------------------------------------------------------------------------------
L
D
I
-
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
PGA
G
N
P
D
G
T
--
V
L
N
A
L
L
H
Y
Y
P
P
I
A
D
V----
P
R
--
A
G
I
--
V
H
R
L
D
K
D
T
T
G
L
M
V
-
V
A
K
T
V
P
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
G
G
-
T
-
V
--
D
---
E
P
I
S
R
H
P
T
K
R
T
H
M
A
-
V
-
H
--
P
M
G
K
P
-----
A
V
T
H
-----
Y
R
---
I
M
E
H
-
F
-
R
V
H
T
R
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
-
G
GRPRP-----
P
K
---------------
G
----------
A
---------------
S
E
A
F
I
S
T
L
R
K
FD
R
Q
A
L
H
A
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
W
H
A
P
-
I
-
P
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
--------
22
HHSearch
87.75
29%
-90
- C6 -
1V9F
1
RLUD_ECOLI
A:
[76-314]
----------------------------------------------------------------------------------
F
E
P
-
Q
D
I
P
L
D
I
-
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
---
P
G
A
G
N
P
--
D
G-
T
V
L
N
A
L
L
H
Y
Y
P
PIADV
P
R
--
A
G
I
--
V
H
R
L
D
K
D
T
T
G
L
M
V
-
V
A
K
T
V
P
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
-
G
-
G
-
T
V
D
E
---
P
I
S
R
H
P
T
K
R
T
H
M
A
V
-
H
----
P
M
G
K
P
-----
A
V
T
H
-----
Y
R
---
I
M
E
H
-
F
-
R
V
H
T
R
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
-
G
----------
G
R
---------------
P
----------
R
PPKGAS
E
A
F
I
S
T
L
R
K
F
D
----------
R
Q
A
L
H
A
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
W
H
A
P
-
I
P
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
E
--------
23
HHSearch
85.76
32%
-88
- C6 -
1V9K
1
RLUC_ECOLI
A:
[3-227]
-------------------------------------------------------------------------------------------
V
I
-
M
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
---
G
G
S
G
L
S
--
F
--
G
V
I
E
G
L
R
A
L
R
P
EA---
R
F
--
L
E
L
--
V
H
R
L
D
R
D
T
S
G
V
L
L
-
V
A
K
K
R
S
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
W
Q
S
H
V
-
K
-
S
V
Q
A
---
P
L
L
K
N
I
L
Q
S
G
E
R
I
V
R
V
-
S
--
Q
E
G
K
P
-----
S
E
T
R
-----
F
K
---
V
E
E
R
-
Y
-
A
F
A
T
L
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
-
G
----------
D
R
---------------
E
F
D
R
Q
L
T
E
A
GT
G
---------------
L
N
----------
R
L
F
L
H
A
A
A
L
K
F
T
H
P
G
T
G
E
V
M
R
I
E
A
P
-
M
D
E
G
L
K
R
C
L
Q
K
M
R
N
A
R
---------
21
PsiBlast_CBE
85.42
33%
-94
- C6 -
1XPI
2
RLUC_ECOLI
B:
[1-215]
---------------------------------------------------------------------------------------
A
A
L
A
D
V
I
L
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
---
G
G
S
G
L
S
--
F
--
G
V
I
E
G
L
R
A
L
R
P
-----
E
A
--
R
F
L
E
L
V
H
R
L
D
R
D
T
S
G
V
L
L
-
V
A
K
K
R
S
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
W
Q
S
H
V
-
K
-
S
V
Q
A
---
P
L
L
K
N
I
L
Q
S
G
E
R
I
V
-
R
V
S
--
Q
E
G
K
P
-----
S
E
T
R
-----
F
K
---
V
E
E
R
-
Y
-
A
F
A
T
L
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
-
G
D
R
E
F
D
R
Q
L
T
E
A
G
---------------
T
----------
G
---------------
L
N
----------
R
L
F
L
H
A
A
A
L
K
F
T
H
P
G
T
G
E
V
M
R
I
E
A
P
-
M
-
D
E
G
L
K
R
C
L
Q
K
L
R
N
----------
1
PsiBlast_PDB
84.94
33%
-96
- C6 -
1XPI
3
RLUC_ECOLI
A:
[1-215]
---------------------------------------------------------------------------------------
A
A
L
A
D
V
I
L
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
---
G
G
S
G
L
S
--
F
--
G
V
I
E
G
L
R
A
L
R
-------
A
--
R
F
L
E
L
V
H
R
L
D
R
D
T
S
G
V
L
L
-
V
A
K
K
R
S
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
W
Q
S
H
V
-
K
-
S
V
Q
A
---
P
L
L
K
N
I
L
Q
S
G
E
R
I
V
-
R
V
S
--
Q
E
G
K
P
-----
S
E
T
R
-----
F
K
---
V
E
E
R
-
Y
-
A
F
A
T
L
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
-
G
D
R
E
F
D
R
Q
L
T
E
A
G
---------------
T
----------
G
---------------
L
N
----------
R
L
F
L
H
A
A
A
L
K
F
T
H
P
G
T
G
E
V
M
R
I
E
A
P
-
M
-
D
E
G
L
K
R
C
L
Q
K
L
R
N
A
R
--------
24
HHSearch
82.45
30%
-95
- C6 -
2I82
2
RLUA_ECOLI
A:
[8-215]
--------------------------------------------------------------------------------------
Q
E
P
W
L
V
I
-
L
Y
Q
D
D
H
I
M
V
-
V
N
K
P
S
G
L
L
S
V
---
P
G
R
L
E
E
H-
K
D-
S
V
M
T
R
I
Q
R
D
Y
P
------
Q
--
A
E
S
--
V
H
R
L
D
M
A
T
S
G
V
I
V
-
V
A
L
T
K
A
A
E
R
E
L
K
R
Q
F
R
E
R
E
P
K
K
Q
Y
V
A
R
V
W
G
H
P
S
P
A
E
-
G
-
L
V
D
L
---
P
L
I
C
D
W
P
N
R
P
K
Q
K
V
-
C
-
Y
--
E
T
G
K
P
-----
A
Q
T
E
-----
Y
E
---
V
V
E
Y
-
A
A
D
N
T
A
R
V
V
L
K
P
I
T
G
R
S
H
Q
L
R
V
H
-
M
L
A
L
G
H
P
I
L
G
D
R
F
Y
-
A
----------
S
P
---------------
E
A
R
A
-------
M
---------------
A
P
----------
R
L
L
L
H
A
E
M
L
T
I
T
H
P
A
Y
G
N
S
M
T
F
K
A
P
-
A
-
D
F
---------------------
2
PsiBlast_PDB
82.02
32%
-87
- C6 -
1V9K
1
RLUC_ECOLI
A:
[6-212]
-----------------------------------------------------------------------------------------------
Y
E
D
D
H
I
L
V
-
L
N
K
P
S
G
T
A
V
H
---
G
G
S
G
L
S
--
F
--
G
V
I
E
G
L
R
A
L
R
P
-----
E
A
--
R
F
L
E
L
V
H
R
L
D
R
D
T
S
G
V
L
L
-
V
A
K
K
R
S
A
L
R
S
L
H
E
Q
L
R
E
K
G
M
Q
K
D
Y
L
A
L
V
R
G
Q
W
Q
S
H
V
-
K
-
S
V
Q
A
---
P
L
L
K
N
I
L
Q
S
G
E
R
I
V
-
R
V
S
--
Q
E
G
K
P
-----
S
E
T
R
-----
F
K
---
V
E
E
R
-
Y
-
A
F
A
T
L
V
R
C
S
P
V
T
G
R
T
H
Q
I
R
V
H
-
T
Q
Y
A
G
H
P
I
A
F
D
D
R
Y
-
G
D
R
E
F
D
R
Q
L
T
E
A
G
---------------
T
----------
G
---------------
L
N
----------
R
L
F
L
H
A
A
A
L
K
F
T
H
P
G
T
G
E
V
M
R
I
E
A
P
-
M
-
D
E
G
L
K
R
C
L
Q
K
M
R
N
A
R
--------
7
PsiBlast_PDB
79.94
30%
-89
- C6 -
2I82
2
RLUA_ECOLI
A:
[15-215]
----------------------------------------------------------------------------------------------
L
Y
Q
D
D
H
I
M
V
-
V
N
K
P
S
G
L
L
S
V
---
P
G
R
L
E
E
HK
D
--
S
V
M
T
R
I
Q
R
D
Y
P
-----
Q
---
A
E
S
--
V
H
R
L
D
M
A
T
S
G
V
I
V
-
V
A
L
T
K
A
A
E
R
E
L
K
R
Q
F
R
E
R
E
P
K
K
Q
Y
V
A
R
V
W
G
H
P
S
P
A
E
-
G
-
L
V
D
L
---
P
L
I
C
D
W
P
N
R
P
K
Q
K
V
-
C
-
Y
--
E
T
G
K
P
-----
A
Q
T
E
-----
Y
E
---
V
V
E
Y
-
A
A
D
N
T
A
R
V
V
L
K
P
I
T
G
R
S
H
Q
L
R
V
H
-
M
L
A
L
G
H
P
I
L
G
D
R
F
Y
A
S
----------
P
E
---------------
A
----------
R
A
M
-------------
A
P
----------
R
L
L
L
H
A
E
M
L
T
I
T
H
P
A
Y
G
N
S
M
T
F
K
A
P
-
A
-
D
F
---------------------
6
PsiBlast_PDB
67.27
33%
-47
- C6 -
1QYU
-
RLUD_ECOLI
A:
[84-300]
------------------------------------------------------------------------------------------
L
D
I
-
V
Y
E
D
E
D
I
I
I
-
I
N
K
P
R
D
L
V
V
H
PGA
G
N
P
D
G
T
--
V
L
N
A
L
L
H
Y
Y
P
P
I
A
D
V----
P
R
--
A
G
I
--
V
H
R
L
D
K
D
T
T
G
L
M
V
-
V
A
K
T
V
P
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
G
G
-
T
-
V
-
D
E
---
P
I
S
R
H
P
T
K
R
T
H
M
A
V
-
H
-
P
--
M
-
G
K
P
-----
A
V
T
H
-----
Y
R
---
I
M
E
H
-
F
-
R
V
H
T
R
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
-
G
GRPRP-----
P
K
---------------
G
----------
A
---------------
S
E
A
F
I
S
T
L
R
K
FD
R
Q
A
L
H
A
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
W
H
A
P
-
I
-
P
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
--------
5
PsiBlast_PDB
65.62
33%
-30
- C6 -
1PRZ
-
RLUD_ECOLI
A:
[84-300]
------------------------------------------------------------------------------------------
L
D
I
-
V
Y
E
D
E
D
I
I
V
-
I
N
K
P
R
D
L
V
V
H
PGA
G
N
P
D
G
T
--
V
L
N
A
L
L
H
Y
Y
P
P
I
A
D
V----
P
R
--
A
G
I
--
V
H
R
L
D
K
D
T
T
G
L
M
V
-
V
A
K
T
V
P
A
Q
T
R
L
V
E
S
L
Q
R
R
E
I
T
R
E
Y
E
A
V
A
I
G
H
M
T
A
G
G
-
T
-
V
-
D
E
---
P
I
S
R
H
P
T
K
R
T
H
M
A
V
---
H
--
P
M
G
K
P
-----
A
V
T
H
-----
Y
R
---
I
M
E
H
-
F
-
R
V
H
T
R
L
R
L
R
L
E
T
G
R
T
H
Q
I
R
V
H
-
M
A
H
I
T
H
P
L
V
G
D
P
V
Y
-
G
G
R
P
R
P
-----
P
K
---------------
G
----------
A
---------------
S
E
A
F
I
S
T
L
R
K
FD
R
Q
A
L
H
A
T
M
L
R
L
Y
H
P
I
S
G
I
E
M
E
W
H
A
P
-
I
-
P
Q
D
M
V
E
L
I
E
V
M
R
A
D
F
--------
25
HHSearch
55.66
17%
-80
- C6 -
1VIO
4
RSUA_HAEIN
A:
[15-209]
------------------------------
L
T
R
S
Q
A
T
K
A
I
R
Q
S
A
V
K
----
I
N
G
E
I
V
K
S
G
S
V
Q
I
S
Q
E
D
E
I
Y
F
E
--
D
E
--------------
L
L
T
-
W
I
E
E
G
Q
Y
F
M
-
L
N
K
P
Q
G
C
V
C
S
---
N
D
--
D
Y
--
P
--
T
I
Y
Q
F
F
D
Y
P
L
A
-----
G
K
--
L
H
S
--
A
G
R
L
D
V
D
T
T
G
L
V
L
-
L
T
D
D
G
Q
W
S
H
R
I
T
S
P
--
K
H
H
C
E
K
T
Y
L
V
T
L
A
D
P
V
E
E
N
Y
-
S
A
A
C
A
E
---
G
I
L
L
R
G
---------
E
-
K
--
E
P
T
K
P
-----
A
--
K
-----
L
E
---
I
L
D
------
D
Y
N
V
N
L
T
I
S
E
G
R
Y
H
Q
V
K
R
M
-
F
A
A
L
G
N
K
V
V
G
L
H
R
W
-
K
----------
I
G
---------------
D
----------
V
---------------
V
L
----------
D
E
S
L
E
E
G
E
Y
R
P
L
T
Q
S
E
I
E
K
L
V
------------------------------
27
HHSearch
55.46
17%
-92
- C6 -
3DH3
1
RLUF_ECOLI
A:
[18-207]
-----------------------------
I
C
S
R
R
E
A
D
R
Y
I
E
Q
G
N
V
F
----
L
N
G
K
R
A
T
-
I
G
D
Q
V
K
P
G
D
V
V
K
V
N
--
G
Q
L
I
--------
E
----
P
R
-
E
A
E
D
L
V
L
I
A
-
L
N
K
P
V
G
I
V
S
T
---
T
E
D
G
E
R
--
D
--
N
I
V
D
F
V
N
H
S
-------
K
R
--
V
F
P
--
I
G
R
L
D
K
D
S
Q
G
L
I
F
-
L
T
N
H
G
D
L
V
N
K
I
L
R
A
G
--
N
D
H
E
K
E
Y
L
V
T
V
D
K
P
I
T
E
E
F
----
I
R
G
----
M
S
----
A
G
-
V
-
P
I
---------
L
G
-----
T
V
T
K
-----
K
C
---
K
V
K
K
---
E
A
P
F
V
F
R
I
T
L
V
Q
G
L
N
R
Q
I
R
R
M
-
C
E
H
F
G
Y
E
V
K
K
L
E
R
T
-
R
----------
I
M
---------------
N
----------
V
---------------
S
L
----------
S
G
I
P
L
G
E
W
R
D
L
T
D
D
E
L
I
D
L
F
K
L
I
E
N
-
S
-
S
S
E
V
-------------------
26
HHSearch
52.55
14%
-70
* C6 *
1KSK
1
RSUA_ECOLI
A:
[16-210]
------------------------------
V
S
R
A
I
A
G
R
E
I
R
G
N
R
V
T
----
V
D
G
E
I
V
R
N
A
A
F
K
L
L
P
E
H
D
V
A
Y
D
--
G
N
P
-------------
L
A
--
Q
Q
H
G
P
R
Y
F
M
-
L
N
K
P
Q
G
Y
V
C
S
---
T
D
D
P
D
H
--
P
--
T
V
L
Y
F
L
D
E
P
V
A
-----
W
K
--
L
H
A
--
A
G
R
L
D
I
D
T
T
G
L
V
L
-
M
T
D
D
G
Q
W
S
H
R
I
T
S
P
--
R
H
H
C
E
K
T
Y
L
V
T
L
E
S
P
V
A
D
---
D
-
T
A
E
Q
---
F
A
K
G
-------
V
Q
L
-
H
-
N
EK
D
L
T
K
P
-----
A
V
L
E
-----
V
I
-----------
T
P
T
Q
V
R
L
T
I
S
E
G
R
Y
H
Q
V
K
R
M
-
F
A
A
V
G
N
H
V
V
E
L
H
R
E
-
R
----------
I
G
---------------
G
----------
I
---------------
T
L
----------
D
A
D
L
A
P
G
E
Y
R
P
L
T
E
E
E
I
A
S
V
V
------------------------------
29
HHSearch
49.62
20%
-58
- C6 -
2OLW
4
RLUE_ECOLI
A:
[37-201]
------------------------------------------------------------------------------------------------
Q
P
T
R
V
I
L
-
F
N
K
P
Y
D
V
L
P
Q
---
F
T
D
E
A
G
--
R
K-
T
L
K
E
F
I
P
V
--------
Q
G
--
V
Y
A
--
A
G
R
L
D
R
D
S
E
G
L
L
V
-
L
T
N
N
G
A
L
Q
A
R
L
T
Q
P
G
--
K
R
T
G
K
I
Y
Y
V
Q
V
E
G
I
P
T
Q
D
A
L
E
-
A
L
R
N
---
G
V
T
L
N
D
--
G
-
P
--
T
-
L
----
P
A
G
A
E
L
V
D
EP
A
W
L
W
-----
P
R
NPP
I
R
-
R
K
S
-
I
P
T
S
W
L
K
I
T
L
Y
E
G
R
N
R
Q
V
R
R
M
-
T
A
H
V
G
F
P
T
L
R
L
I
R
Y
-
A
----------
M
G
---------------
D
----------
Y
---------------
S
L
----------
D
N
L
A
N
G
E
W
R
E
V
T
---------------------------------------
46
Fugue
48.90
14%
-45
- C4 -
1JDI
1
ARAD_ECOLI
A:
[1-223]
-----------------------------
M
L
E
D
L
K
R
Q
V
L
E
A
N
L
A
L
P
K
H
NL
V
T
L
T
W
G
N
-
V
S
A
V
D
R
E
R
G
V
F
V
I
K
P
S
G
V
D
Y
S
I
---------------
M
T
A
D
D
M
V
V
-
V
S
I
E
T
G
E
V
V
E
---
G
A
K
K
P
S
--
S
--
D
T
P
T
H
R
L
L
Y
Q
A
-----
F
P
SI
G
G
I
--
V
H
---
T
H
S
R
H
A
T
I
-
W
A
Q
A
G
Q
S
I
P
A
T
G
T
T
H
A
D
Y
----------------------
F
Y
G
---
T
I
P
C
T
R
K
M
T
D
A
E
I
N
-
G
-
E
--
Y
E
W
E
T
-----
G
N
V
I
-----
V
E
---
T
F
E
K
-
Q
-
G
I
D
A
----------
A
Q
M
P
G
V
L
-
V
H
S
H
G
P
F
A
W
G
K
N
A
E
-
D
----------
A
V
---------------
H
----------
N
---------------
A
I
----------
V
L
E
E
V
A
Y
M
G
I
F
C
R
Q
L
-----
A
P
Q
L
P
-
D
-
M
Q
Q
T
L
L
N
K
H
Y
L
R
K
H
---------
30
HHSearch
48.52
18%
-87
- C6 -
2GML
-
RLUF_ECOLI
A:
[1-144]
-------------------------------------------------------------------------------------------------
D
L
V
L
I
A
-
L
N
K
P
V
G
I
V
S
T
---
T
E
D
G
E
R
--
D
--
N
I
V
D
F
V
N
H
S
-------
K
R
--
V
F
P
--
I
G
R
L
D
K
D
S
Q
G
L
I
F
-
L
T
N
H
G
D
L
V
N
K
I
L
R
A
G
N
--
D
H
E
K
E
Y
L
V
T
V
D
K
P
I
T
E
E
F
----
I
R
G
----
M
S
----
A
G
-
V
-
P
I
---------
L
G
-----
T
V
T
K
-----
K
C
---
K
V
K
K
---
E
A
P
F
V
F
R
I
T
L
V
Q
G
L
N
R
Q
I
R
R
M
-
C
E
H
F
G
Y
E
V
K
K
L
E
R
T
-
R
----------
I
M
---------------
N
----------
V
---------------
S
L
----------
S
G
I
P
L
G
E
W
R
D
L
T
D
D
E
L
I
D
L
F
K
L
I
E
N
-
S
-
S
----------------------
28
HHSearch
47.28
20%
-59
- C6 -
2OML
5
RLUE_ECOLI
A:
[8-173]
-----------------------------------------------------------------------------------------------
N
Q
P
T
R
V
I
L
-
F
N
K
P
Y
D
V
L
P
Q
---
F
T
D
E
A
G
--
R
K-
T
L
K
E
F
I
P
V
--------
Q
G
--
V
Y
A
--
A
G
R
L
D
R
D
S
E
G
L
L
V
-
L
T
N
N
G
A
L
Q
A
R
L
T
Q
P
G
K
--
R
T
G
K
I
Y
Y
V
Q
V
E
G
I
P
T
Q
D
----
A
L
E
A
L
R
N
G
V
T
L
N
D
G
---
P
--
T
---
L
--
P
A
G
A
E
-----
L
V
D
E
PAW
L
W
P
R
NPP
I
R
-
R
K
S
-
I
P
T
S
W
L
K
I
T
L
Y
E
G
R
N
R
Q
V
R
R
M
-
T
A
H
V
G
F
P
T
L
R
L
I
R
Y
-
A
----------
M
G
---------------
D
----------
Y
---------------
S
L
----------
D
N
L
A
N
G
E
W
R
E
V
T
D
--------------------------------------
44
Fugue
46.33
13%
-60
- C6 -
1KSK
1
RSUA_ECOLI
A:
[1-234]
--------------------G
S
H
M
R
L
D
K
F
I
A
Q
Q
L
G
V
S
R
A
I
A
G
R
E
I
R
----
G
N
R
V
T
V
D
-
G
E
I
V
R
N
A
A
F
K
L
L
--------
P
E
H
D
V
A
Y
D
G
N
P
L
----
A
Q
Q
H
G
P
R
Y
F
M
L
N
K
P
Q
G
Y
V
C
S
---
T
D
D
P
D
H
--
P
--
T
V
L
Y
F
L
D
E
P
V
A
-----
W
K
--
L
H
A
--
A
G
R
L
D
I
D
T
T
G
L
V
L
M
T
D
D
G
Q
W
S
H
R
I
T
S
P
R
---
H
H
C
E
K
T
Y
L
V
T
L
E
S
P
V
A
D
D
-------------
T
A
E
Q
F
A
K
G
V
Q
L
H
-
N
-
E
--
K
D
L
T
K
-----
P
A
V
L
-----
E
V
---
I
T
P
-------
T
Q
V
R
L
T
I
S
E
G
R
Y
H
Q
V
K
-
R
M
F
A
A
V
G
N
H
-----------------------------------------------------------------------------
V
V
E
L
H
R
E
R
I
G
-
G
I
T
---
L
D
A
D
L
A
-
P
-
G
E
Y
R
P
L
T
E
E
E
I
A
S
V
V
--------