@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2033: (2015-12-12 )
MKKITKMVISSVLATVLMTACSQSSQNGQSDVKHIGILQYVEHPSLTATRKGFIKELAKEGYKDGKNIKIEYKNAQGDQSNIQSISEKLIKDNKLVLGIATPAAQSLTTVSTETPILFTAVTDPVSAELVKSMKKPEGLATGTSDMSPIKKQVSLLRKVMPKVKRVGIMYTTSERNSEVQVKQAKKIFQEAGIKTSVKGISSTNDVQDTAKSLMSKTEVIFVPTDNIIASSVTLLGNLSKELKVPVVGGSADMVPSGLLFSYGADYEALGRQTARQAVKILKGKDVAKVPSEYPQNLKVVVNEDMAKELGIDVSSIKNNK
Atome Classification :
(20 SA)
--------.........10........20........30........40--.-...--....50........60........70..-......80........90.--.....-..100-..---.-..-....-110.........120.......130.......140.......150.......160........170.--.-.--....180.......190-.----..-----...--.--.----200----....--.....210..---.---..---..220.......230.......240-.--.......------.250-----.-----.--.---.---.-.-.260.......270.......280..-.....290.......300......-----------------.310...-....320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------M
K
K
I
T
K
M
V
I
S
S
V
L
A
T
V
L
M
T
A
CSQSSQNGQ
S
D
V
K
H
I
G
I
L
Q
Y
V--E-HPS--L
T
A
T
R
K
G
F
I
K
E
L
A
KEGYKDG
K
N
I
K
I
E
Y
K-NAQGD
Q
S
N
I
Q
S
I
S
E
K
L
IKD--N
K
L
V
L
-
G
IA---TP---A-AQ-
S
L
T
T-V--STET
P
I
L
F
T
AVTDP
V
S
A
E
L
V
K
S
MKKPEGLATGTS
D
M
S
P
I
K
K
Q
V
S
L
L
R
K
V
M
-
P
K
V
K
RV
G
I
M
Y
TTS--E-R--NS
E
V
Q
V
K
Q
A
K
K
I
F
Q
EA--G----I
K
-----
T
SV--K--G----I------SSTN--
D
V
Q
D
T
A
K
S
L
M---S---KT---
E
V
I
F
VPTD
N
I
I
A
S
S
V
T
L
L
GNL
S
K
---E--LKV
P
V
VG------GSAD-----M-----V--P---S---G-
L
-
L
FSYGA
D
Y
E
A
L
G
R
Q
T
A
R
Q
A
V
K
I
LKGK-
D
V
A
KV
P
S
EYPQ
N
L
K
V
V
V
N
E
D
M
A
K
E
-----------------LGI
D
V
S
S
-IKNNK-
1
PsiBlast_PDB
96.39
40%
-66
- C2 -
3LFT
1
?
A:
[5-283]
------------------------------------------
I
G
V
L
Q
F
V
--
S
-
H
P
S
--
L
D
L
I
Y
K
G
I
Q
D
G
L
A
E
E
G
Y
K
D
D
Q
-
V
K
I
D
F
M
-
N
S
E
G
D
Q
S
K
V
A
T
M
S
K
Q
L
V
A
N
G-
N
D
L
V
V
-
G
I
A
---
T
P
---
A
-
A
Q
-
G
L
A
S
-
A
--
T
K
D
L
P
V
I
M
A
A
I
T
D
P
I
G
A
N
L
V
K
D
L
K
K
P
G
G
N
V
T
G
V
S
D
H
N
P
A
Q
Q
Q
V
E
L
I
K
A
L
T
-
P
N
V
K
T
I
G
A
L
Y
S
S
S
--
E
-
D
--
N
S
K
T
Q
V
E
E
F
K
A
Y
A
E
K
A
--
G
----
L
T
-----
V
E
T
--
F
--
A
----
V
------
P
S
T
N
--
E
I
A
S
T
V
T
V
M
T
---
S
---
K
V
---
D
A
I
W
V
P
I
D
N
T
I
A
S
G
F
P
T
V
V
S
S
N
Q
---
S
--
S
K
K
P
I
Y
P
------
S
A
T
A
-----
M
-----
V
--
E
---
V
---
G
-
G
-
L
A
S
V
V
I
D
Q
H
D
L
G
V
A
T
G
K
M
I
V
Q
V
L
K
G
A
-
K
P
A
D
T
P
V
N
V
F
S
T
G
K
S
V
I
N
K
K
I
A
Q
E
-----------------
L
G
I
T
I
P
E
-
S
V
L
K
E
-
21
HHSearch
95.50
39%
-59
- C2 -
3LFT
1
?
A:
[2-289]
---------------------------------------
N
A
K
I
G
V
L
Q
F
V
--
S
-
H
P
S
--
L
D
L
I
Y
K
G
I
Q
D
G
L
A
E
E
G
Y
K
D
D
-
Q
V
K
I
D
F
M
-
N
S
E
G
D
Q
S
K
V
A
T
M
S
K
Q
L
V
A
N
G-
N
D
L
V
V
-
G
I
A
---
T
P
---
A
-
A
Q
-
G
L
A
S
-
A
--
T
K
D
L
P
V
I
M
A
A
I
T
D
P
I
G
A
N
L
V
K
D
L
K
K
P
G
G
N
V
T
G
V
S
D
H
N
P
A
Q
Q
Q
V
E
L
I
K
A
L
T
-
P
N
V
K
T
I
G
A
L
Y
S
S
S
--
E
-
D
--
N
S
K
T
Q
V
E
E
F
K
A
Y
A
E
K
A
--
G
----
L
T
-----
V
E
T
--
F
--
A
----
V
------
P
S
T
N
--
E
I
A
S
T
V
T
V
M
T
---
S
---
K
V
---
D
A
I
W
V
P
I
D
N
T
I
A
S
G
F
P
T
V
V
S
S
N
Q
---
S
--
S
K
K
P
I
Y
P
------
S
A
T
A
-----
M
-----
V
--
E
---
V
---
G
-
G
-
L
A
S
V
V
I
D
Q
H
D
L
G
V
A
T
G
K
M
I
V
Q
V
L
K
G
A
-
K
P
A
D
T
P
V
N
V
F
S
T
G
K
S
V
I
N
K
K
I
A
Q
E
-----------------
L
G
I
T
I
P
E
-
S
V
L
K
E
-
2
PsiBlast_PDB
94.98
36%
-67
- C2 -
3LKV
6
?
A:
[11-290]
------------------------------------------
V
A
V
S
Q
I
V
--
E
-
H
P
A
--
L
D
A
T
R
Q
G
L
L
D
G
L
K
A
K
G
Y
E
E
G
K
N
L
E
F
D
Y
K
-
T
A
Q
G
N
P
A
I
A
V
Q
I
A
R
Q
F
V
G
E
--
N
P
D
V
L
V
G
I
A
---
T
P
---
T
-
A
Q
-
A
L
V
S
-
A
--
T
K
T
I
P
I
V
F
T
A
V
T
D
P
V
G
A
K
L
V
K
Q
L
E
Q
P
G
K
N
V
T
G
L
S
D
L
S
P
V
E
Q
H
V
E
L
I
K
E
I
L
-
P
N
V
K
S
I
G
V
V
Y
N
P
G
--
E
-
A
--
N
A
V
S
L
M
E
L
L
K
L
S
A
A
K
H
--
G
----
I
K
-----
L
V
E
--
A
--
T
----
A
------
L
K
S
A
--
D
V
Q
S
A
T
Q
A
I
A
---
E
---
K
S
---
D
V
I
Y
A
L
I
D
N
T
V
A
S
A
I
E
G
M
I
V
A
A
N
---
Q
--
A
K
T
P
V
F
G
------
A
A
T
S
-----
Y
-----
V
--
E
---
R
---
G
-
A
-
I
A
S
L
G
F
D
Y
Y
Q
I
G
V
Q
T
A
D
Y
V
A
A
I
L
E
G
K
-
E
P
G
S
L
D
V
Q
V
A
K
G
S
D
L
V
I
N
K
T
A
A
E
Q
-----------------
L
G
I
T
I
P
E
-
A
V
L
A
R
-
20
HHSearch
93.85
34%
-62
- C2 -
3LKV
6
?
A:
[7-296]
--------------------------------------
K
T
A
K
V
A
V
S
Q
I
V
--
E
-
H
P
A
--
L
D
A
T
R
Q
G
L
L
D
G
L
K
A
K
G
Y
E
E
G
K
N
L
E
F
D
Y
K
-
T
A
Q
G
N
P
A
I
A
V
Q
I
A
R
Q
F
V
G
E
N-
P
D
V
L
V
-
G
I
A
---
T
P
---
T
-
A
Q
-
A
L
V
S
-
A
--
T
K
T
I
P
I
V
F
T
A
V
T
D
P
V
G
A
K
L
V
K
Q
L
E
Q
P
G
K
N
V
T
G
L
S
D
L
S
P
V
E
Q
H
V
E
L
I
K
E
I
L
-
P
N
V
K
S
I
G
V
V
Y
N
P
G
--
E
-
A
--
N
A
V
S
L
M
E
L
L
K
L
S
A
A
K
H
--
G
----
I
K
-----
L
V
E
--
A
--
T
----
A
------
L
K
S
A
--
D
V
Q
S
A
T
Q
A
I
A
---
E
---
K
S
---
D
V
I
Y
A
L
I
D
N
T
V
A
S
A
I
E
G
M
I
V
A
A
N
---
Q
--
A
K
T
P
V
F
G
------
A
A
T
S
-----
Y
-----
V
--
E
---
R
---
G
-
A
-
I
A
S
L
G
F
D
Y
Y
Q
I
G
V
Q
T
A
D
Y
V
A
A
I
L
E
G
K
-
E
P
G
S
L
D
V
Q
V
A
K
G
S
D
L
V
I
N
K
T
A
A
E
Q
-----------------
L
G
I
T
I
P
E
-
A
V
L
A
R
-
43
HHSearch
63.34
18%
-51
- C2 -
3C3K
1
?
A:
[7-263]
--------------------------------------
K
T
G
M
L
L
V
M
V
S
N
--
I
A
N
P
F
--
C
A
A
V
V
K
G
I
E
K
T
A
E
K
N
G
Y
R
------
I
L
L
C
-
N
T
E
S
D
L
A
R
S
R
S
C
L
T
L
L
S
G
K
M-
V
D
G
V
I
-
T
M
D
---
A
L
---
S
-
E
L
P
E
L
Q
N
-
I
--
I
G
A
F
P
W
V
Q
C
A
E
Y
D
P
-
L
---------
S
T
V
S
S
V
S
I
D
D
V
A
A
S
E
Y
V
V
D
Q
L
V
K
S
---
G
K
K
R
I
A
L
I
N
H
D
L
--
A
Y
Q
--
Y
A
Q
H
R
E
S
G
Y
L
N
R
L
K
F
H
--
G
----
L
D
-----
Y
S
R
--
I
--
S
----
Y
A
EN---
L
D
Y
M
--
A
G
K
L
A
T
F
S
L
L
KSA
V
---
K
P
---
D
A
I
F
A
I
S
D
V
L
A
A
G
A
I
Q
A
L
T
E
S
G
L
---
S
IP
Q
D
V
A
V
V
G
------
F
D
G
V
-----
D
-----
I
--
S
---
Q
I
TV
P
-
A
-
L
T
T
V
Q
Q
P
S
E
Q
I
G
M
K
A
V
S
L
L
L
E
Q
I
H
S
D
-
V
H
H
L
L
P
W
K
F
V
R
R
Q
S
S
E
---------------------------------------
39
HHSearch
62.61
15%
-48
- C2 -
3ROT
1
?
A:
[3-273]
---------------------------------------
R
D
K
Y
Y
L
I
T
H
G
--
S
Q
D
P
Y
--
W
T
S
L
F
Q
G
A
K
K
A
A
E
E
L
K
V
D
----
L
Q
I
L
A
P
-
P
G
A
N
D
V
P
K
Q
V
Q
F
I
E
S
A
L
A
T
Y-
P
S
G
I
A
-
T
T
I
---
P
S
DT-
A
-
F
S
-
K
S
L
Q
-
R
A
N
K
L
N
I
P
V
I
A
V
D
T
R
P
K
D
K
T
------
K
N
P
Y
L
V
F
L
G
S
D
N
L
L
A
G
K
K
L
G
E
K
A
L
E
L
T
-
P
S
A
K
R
A
L
V
L
N
P
Q
P
G-
H
-
I
--
G
L
E
K
R
A
Y
G
I
K
T
I
L
Q
D
K
--
G
----
I
F
-----
F
E
E
--
L
--
D
V---
G
------
T
D
P
N
--
Q
V
Q
S
R
V
K
S
Y
F
---
K
I
H
P
E
T
---
N
I
I
F
C
L
T
S
Q
A
L
D
P
L
G
Q
M
L
L
H
P
D
R
YDF
N
--
Y
Q
P
Q
V
Y
S
------
F
D
K
T
-----
P
N
T
V
S
L
I
--
H
---
K
---
K
-
L
V
N
Y
V
M
D
Q
Q
P
F
L
M
G
Y
L
S
I
T
Q
L
V
L
M
N
R
Y
Q
L
N
P
V
N
I
N
T
A
M
----------------------------------------------
28
HHSearch
61.15
12%
-58
- C2 -
2O20
3
?
A:
[62-313]
--------------------------------------
R
T
T
T
V
G
V
I
L
P
T
--
I
T
S
T
Y
--
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
K
Y
N
------
M
I
L
A
-
N
S
D
N
D
V
E
K
E
E
K
V
L
E
T
F
L
S
K
Q-
V
D
G
I
V
-
Y
M
G
---
S
S
---
L
-
D
E
-
K
I
R
T
-
S
L
K
N
S
R
T
P
V
V
L
V
G
T
I
-
D
G
D
---------
K
E
I
P
S
V
N
I
D
Y
H
L
A
A
Y
Q
S
T
K
K
L
I
D
S
---
G
N
K
K
I
A
Y
I
M
G
S
L
--
K
D
V
--
E
N
T
E
R
M
V
G
Y
Q
E
A
L
L
E
A
--
N
----
I
E
-----
F
D
E
--
N
--
L
VFEG
N
------
Y
S
Y
E
--
Q
G
K
A
L
A
E
R
L
L
---
E
R
--
G
A
---
T
S
A
V
V
S
H
D
T
V
A
V
G
L
L
S
A
M
M
D
K
G
V
---
K
VP
E
D
F
E
I
I
S
------
G
A
N
S
-----
P
-----
I
--
T
---
Q
YTY
P
-
T
-
L
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
K
E
-
D
V
E
Q
N
Q
L
V
L
D
H
E
I
F
S
R
R
S
T
K
-----------------------------------
27
HHSearch
61.13
12%
-55
- C2 -
3H5O
2
?
A:
[63-313]
----------------------------------------
R
T
V
L
V
L
I
P
S
--
L
A
N
T
V
--
F
L
E
T
L
T
G
I
E
T
V
L
D
A
A
G
Y
Q
------
M
L
I
G
-
N
S
H
Y
D
A
G
Q
E
L
Q
L
L
R
A
Y
L
Q
H
R-
P
D
G
V
L
-
I
T
G
---
L
S
---
H
-
A
E
-
P
F
E
R
-
I
L
S
Q
H
A
L
P
V
V
Y
M
M
D
-
L
A
D
----------
D
G
R
C
C
V
G
F
S
Q
E
D
A
G
A
A
I
T
R
H
L
L
S
R
---
G
K
R
R
I
G
F
L
G
A
Q
L
--
D
-
E
--
R
V
M
K
R
L
D
G
Y
R
A
A
L
D
A
A
--
D
----
C
R
DAGL
E
W
L
D
--
P
--
Q
----
P
------
S
S
M
Q
--
M
G
A
D
M
L
D
R
A
L
---
A
E
RP
D
C
---
D
A
L
F
C
C
N
D
D
L
A
I
G
A
L
A
R
S
Q
Q
L
G
I
---
A
VP
E
R
L
A
I
A
G
------
F
N
D
L
-----
Q
-----
P
AA
W
---
C
---
T
P
P
-
L
T
T
V
A
T
P
R
R
D
I
G
V
H
A
A
K
A
L
L
Q
L
I
D
G
E
-
E
P
A
S
R
R
A
D
L
G
F
R
L
M
L
R
R
S
S
E
G
----------------------------------
37
HHSearch
60.62
15%
-52
* C2 *
2DRI
1
RBSB_ECOLI
A:
[2-257]
----------------------------------------
D
T
I
A
L
V
V
S
T
--
L
N
N
P
F
--
F
V
S
L
K
D
G
A
Q
K
E
A
D
K
L
G
Y
N
------
L
V
V
L
-
D
S
Q
N
N
P
A
K
E
L
A
N
V
Q
D
L
T
V
R
G-
T
K
I
L
L
-
I
N
P
---
T
D
SD-
A
-
V
G
-
N
A
V
K
-
M
A
N
Q
A
N
I
P
V
I
T
L
D
R
Q
A
T
K
G
---------
E
V
V
S
H
I
A
S
D
N
V
L
G
G
K
I
A
G
D
Y
I
A
K
K
A
-
G
E
G
A
K
V
I
E
L
Q
G
I
A
G-
T
-
S
--
A
A
R
E
R
G
E
G
F
Q
Q
A
V
A
A
H
--
K
----
F
N
-----
V
L
A
--
S
--
Q
P
A--
D
------
F
D
R
I
--
K
G
L
N
V
M
Q
N
L
L
T
A
H
P
---
D
V
---
Q
A
V
F
A
Q
N
D
E
M
A
L
G
A
L
R
A
L
Q
T
A
G
K
------
S
D
V
M
V
V
G
------
F
D
G
T
-----
P
D
G
E
K
A
V
--
N
---
D
---
G
-
K
L
A
A
T
I
A
Q
L
P
D
Q
I
G
A
K
G
V
E
T
A
D
K
V
L
K
G
E
-
K
V
Q
A
K
Y
P
V
D
L
K
L
V
V
K
Q
---------------------------------------
30
HHSearch
59.22
13%
-53
- C2 -
2QU7
1
?
A:
[7-261]
--------------------------------------
R
S
N
I
I
A
F
I
V
P
D
--
Q
-
N
P
F
--
F
T
E
V
L
T
E
I
S
H
E
C
Q
K
H
H
L
H
------
V
A
V
A
-
S
S
E
E
N
E
D
K
Q
Q
D
L
I
E
T
F
V
S
Q
N-
V
S
A
I
I
-
L
V
P
---
V
K
---
S
-
K
F
-
Q
M
K
R
-
E
--
W
L
K
I
P
I
M
T
L
D
R
E
-
L
E
S
---------
T
S
L
P
S
I
T
V
D
N
E
E
A
A
Y
I
A
T
K
R
V
L
E
S
---
T
C
K
E
V
G
L
L
L
A
N
P
--
N
I
S
--
T
T
I
G
R
K
N
G
Y
N
K
A
I
S
E
F
--
D
----
L
N
-----
V
N
P
SL
I
HY
S
----
D
QQLG
T
N
A
Q
I
Y
--
S
G
Y
E
A
T
K
T
L
L
---
S
K
--
G
I
---
K
G
I
V
A
T
N
H
L
L
L
L
G
A
L
Q
A
I
K
E
S
E
K
---
E
IK
K
D
V
I
I
V
G
------
F
D
D
S
-----
Y
-----
W
--
N
E
I
Y
T
---
P
-
K
-
L
T
V
I
S
Q
P
V
K
E
M
G
Q
V
A
A
K
M
I
Y
K
L
I
K
G
K
-
D
V
T
S
I
K
L
S
T
K
L
I
I
R
E
S
C
S
F
N
-----------------------------------
35
HHSearch
58.89
15%
-52
- C2 -
3D02
4
?
A:
[4-265]
---------------------------------------
E
K
T
V
V
N
I
S
K
V
--
D
G
M
P
W
--
F
N
R
M
G
E
G
V
V
Q
A
G
K
E
F
N
L
N
----
A
S
-
Q
V
G
-
P
S
S
T
D
A
P
Q
Q
V
K
I
I
E
D
L
I
A
R
K-
V
D
A
I
T
-
I
V
P
---
N
D
AN-
V
-
L
E
-
P
V
F
K
-
K
A
R
D
A
G
I
V
V
L
T
N
E
S
P
G
Q
P
S
---------
A
N
W
D
V
E
I
I
D
N
E
K
F
A
A
E
Y
V
E
H
M
A
K
R
M
-
G
G
K
G
G
Y
V
I
Y
V
G
S
L
--
T
V
P
--
Q
H
N
L
W
A
D
L
L
V
K
Y
Q
K
E
H
YP
D
----
M
H
-----
E
V
T
--
R
R-
M
PV--
A
------
E
S
V
D
--
D
S
R
R
T
T
L
D
L
M
K
T
Y
P
---
D
L
---
K
A
V
V
S
F
G
S
N
G
P
I
G
A
G
R
A
V
K
E
K
R
A
---
K
--
N
K
V
A
V
Y
G
------
M
M
I
P
SQA
A
S
L
-----
I
--
K
---
S
---
G
-
D
I
T
E
G
I
T
Y
D
P
A
T
A
G
Y
A
L
A
A
V
A
S
T
L
L
N
G
K
-
T
I
E
P
G
F
E
L
K
E
L
G
K
A
E
V
D
S
D
K
H
I
I
R
-----------------
F
H
K
V
L
L
V
-
N
K
D
N
I
-
47
Fugue
58.31
12%
-24
- C2 -
1JX6
2
LUXP_VIBHA
A:
[4-341]
GYWG
Y
Q
E
F
L
D
E
F
P
E
Q
R
N
L
T
N
A
L
S
E
A
V
R
A
Q
P
V
P
L
S
K
P
T
Q
R
P
I
K
I
S
V
V
Y
P
G
--
Q
-
Q
V
S
D
Y
W
V
R
N
I
A
S
F
E
K
R
L
Y
K
L
N
I
N
--
Y
Q
L
N
Q
V
F
T
-
R
P
N
A
D
I
K
Q
Q
S
L
S
L
M
E
A
L
K
S
KS
D
Y
L
I
F
-
T
L
D
---
T
T
---
R
-
H
R
-
K
F
V
E
-
H
--
V
L
D
S
T
N
T
K
L
I
L
Q
N
I
T
T
P
V
R
E
W
D
K
H
Q
P
F
-
L
Y
V
G
F
D
H
A
E
G
S
R
E
L
A
T
E
F
G
K
F
F
-
P
K
H
T
Y
Y
S
V
L
Y
F
S
E
--
G
-
Y
--
I
S
D
V
R
G
D
T
F
I
H
Q
V
N
R
D
--
N
NFE-
L
Q
-----
S
A
Y
--
Y
--
T
----
K
------
A
T
K
Q
--
S
G
Y
D
A
A
K
A
S
L
---
A
---
K
H
PDV
D
F
I
Y
A
C
S
T
D
V
A
L
G
A
V
D
A
L
A
E
L
G
R
---
E
---
D
I
M
I
N
G
W
GGG
S
A
E
L
D
A
-----
I
-----
Q
--
K
---
G
---
D
-
L
-
D
I
T
V
M
R
M
N
D
D
T
G
I
A
M
A
E
A
I
K
W
D
L
E
D
K
----
P
V
P
T
V
Y
S
G
D
F
E
I
V
T
K
A
D
S
P
E
R
-----------------
I
E
A
L
K
K
R
A
F
R
Y
S
D
-
22
HHSearch
58.06
12%
-47
- C2 -
3EGC
-
?
A:
[66-320]
--------------------------------------
R
S
N
V
V
G
L
I
V
S
D
--
I
E
N
V
F
--
F
A
E
V
A
S
G
V
E
S
E
A
R
H
K
G
Y
S
------
V
L
L
A
-
N
T
A
E
D
I
V
R
E
R
E
A
V
G
Q
F
F
E
R
R-
V
D
G
L
I
-
L
A
P
---
S
E
---
G
-
E
H
-
D
Y
L
R
-
T
E
L
P
K
T
F
P
I
V
A
V
N
R
E
L
R
I
----------
P
G
C
G
A
V
L
S
E
N
V
R
G
A
R
T
A
V
E
Y
L
I
A
R
---
G
H
T
R
I
G
A
I
V
G
S
A
--
G
L
M
--
T
S
R
E
R
L
K
G
F
R
A
A
M
S
A
A
--
G
----
L
P
-----
V
R
Q
--
E
--
W
IAA--------------
N
G
R
D
G
A
I
K
V
L
T
G-
D
---
R
P
---
T
A
L
L
T
S
S
H
R
I
T
E
G
A
M
Q
A
L
N
V
L
G
L
---
R
YG
P
D
V
E
I
V
S
------
F
D
N
L
-----
P
-----
W
--
M
A
F
L
D
---
P
-
P
-
L
P
V
V
E
Q
P
T
R
R
I
G
Q
E
A
M
R
M
L
I
H
M
I
E
G
T
-
G
N
A
T
E
M
R
L
Q
T
R
F
V
T
H
----------------------------------------
50
Fugue
57.91
12%
-38
- C2 -
1TJY
1
LSRB_SALTY
A:
[1-316]
-------------------------------------
G
S
A
E
R
I
A
F
I
P
K
L
--
V
-
G
V
G
--
F
F
T
S
G
G
N
G
A
Q
E
A
G
K
A
L
-----
G
I
D
V
T
Y
D
G
P
T
E
P
S
V
S
G
Q
V
Q
L
V
N
N
F
V
N
Q
--
G
Y
D
A
I
-
I
V
S
AVS
P
D
---
G
-
L
C
-
P
A
L
K
-
R
--
A
M
Q
R
G
V
K
I
L
T
W
D
S
D
T
K
P
E
C
R
-----
S
Y
Y
I
N
Q
G
T
P
K
Q
L
G
S
M
L
V
E
M
A
A
H
Q
V
D
K
E
K
A
K
V
A
F
F
Y
S
S
P
T
--
V
-
T
--
D
Q
N
Q
W
V
K
E
A
K
A
K
I
S
Q
E
--
H
PGWE
I
V
-----
T
T
Q
--
F
--
G
----
Y
------
N
D
A
T
--
K
S
L
Q
T
A
E
G
I
I
---
K
---
A
Y
PDL
D
A
I
I
A
P
D
A
N
A
L
P
A
A
A
Q
A
A
E
N
L
K
R
---
N
---
N
L
A
I
V
G
F
S
T
PNV
M
R
P
Y
-----
V
-----
Q
--
R
---
G
---
T
-
V
-
K
E
F
G
L
W
D
V
V
Q
Q
G
K
I
S
V
Y
V
A
N
A
L
L
K
N
M
-
P
M
N
V
G
D
S
L
D
I
P
G
I
G
K
V
T
V
S
P
N
S
E
Q
GYHYEAKG
N
G
I
V
L
L
P
E
R
V
I
F
N
K
D
N
-
I
D
K
Y
D
F
26
HHSearch
57.45
12%
-53
- C2 -
2FEP
2
CCPA_BACSU
A:
[16-269]
---------------------------------------
T
T
T
V
G
V
I
I
P
D
--
I
S
S
I
F
--
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
------
I
I
L
S
-
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q-
V
D
G
I
V
-
F
M
G
---
G
N
---
I
T
D
E
-
H
V
A
E
F
K
--
R
S
P
V
P
I
V
L
A
A
S
V
-
E
E
Q
---------
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
---
G
H
T
D
I
A
F
V
S
G
P
M
--
A
-
E
PI
N
R
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
----
L
P
-----
F
N
E
QF
V
A
E
G
----
D
------
Y
T
Y
D
--
S
G
L
E
A
L
Q
H
L
M
S
LD
K
---
K
P
---
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
---
S
IP
E
D
L
D
I
I
G
------
F
D
N
T
-----
R
-----
L
--
S
LMV
R
---
P
-
Q
-
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
-
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
-----------------------------------
45
HHSearch
56.93
13%
-52
- C2 -
3CTP
2
?
A:
[60-305]
---------------------------------------
S
K
T
I
G
L
M
V
P
N
I-
S
-
N
P
F
--
F
N
Q
M
A
S
V
I
E
E
Y
A
K
N
K
G
Y
T
------
L
F
L
C
-
N
T
D
D
D
K
E
K
E
K
T
Y
L
E
V
L
Q
S
H
R-
V
A
G
I
I
-
A
S
R
---
S
Q
---
C
-
E
D
-
E
Y
A
-----
N
I
D
I
P
V
V
A
F
E
N
H
-
I
L
----------
D
N
I
I
T
I
S
S
D
N
Y
N
G
G
R
M
A
F
D
H
L
Y
E
K
---
G
C
R
K
I
L
H
I
K
G
P
E
--
V
-
F
E
-
A
T
E
L
R
Y
K
G
F
L
D
G
A
R
A
K
--
D
----
L
E
-----
I
D
F
--
I
--
E
----
F
QHD---
F
Q
V
K
--
M
L
E
E
D
I
N
S
M
K
DI-
V
---
N
Y
---
D
G
I
F
V
F
N
D
I
A
A
A
T
V
M
R
A
L
K
K
R
G
V
---
S
IP
Q
E
V
Q
I
I
G
------
F
D
N
S
-----
F
-----
I
--
G
E
L
L
Y
---
P
-
S
-
L
T
T
I
N
Q
P
I
E
A
L
A
Y
T
I
I
E
L
L
I
K
I
I
N
G
E
-
G
V
L
I
E
D
Y
I
M
E
V
K
L
I
E
R
E
T
T
I
S
----------------------------------
41
HHSearch
55.77
12%
-45
- C2 -
1QPZ
1
PURR_ECOLI
A:
[56-312]
-------------------------------------
N
H
T
K
S
I
G
L
L
A
T
S
--
S
E
A
A
Y
--
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
------
L
I
L
G
-
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R-
V
D
G
L
L
-
V
M
C
---
S
E
YP
E
P
-
L
L
-
A
M
L
E
-
E
--
Y
R
H
I
P
M
V
V
M
D
W
G
E
A
K
A
---------
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
---
G
H
R
E
I
G
V
I
P
G
P
L
--
E
R
N
--
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
--
M
----
I
K
-----
V
P
E
--
S
W
I
V
Q
G
--
D
------
F
E
P
E
--
S
G
Y
R
A
M
Q
Q
I
L
---
S
QPH
R
P
---
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
---
R
VP
Q
D
V
S
L
I
G
------
Y
D
N
V
-----
R
-----
N
--
A
RY-
F
---
T
P
A
-
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
-
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
P
F
-----------------
R
D
Y
R
----------
38
HHSearch
52.75
13%
-38
- C2 -
3BRS
-
?
A:
[5-266]
---------------------------------------
Q
Y
Y
M
I
C
I
P
K
V
LD
D
S
S
D
F
--
W
S
V
L
V
E
G
A
Q
M
A
A
K
E
Y
E
I
K
----
L
E
F
M
A
P
-
E
K
E
E
D
Y
L
V
Q
N
E
L
I
E
E
A
I
K
R
K-
P
D
V
I
L
-
L
A
A
---
A
D
YE-
K
-
T
Y
-
D
A
A
K
-
E
IK
D
A
G
I
K
L
I
V
I
D
S
G
M
K
Q
D
---------
I
A
D
I
T
V
A
T
D
N
I
Q
A
G
I
R
I
G
A
V
T
K
N
L
V
-
R
K
S
G
K
I
G
V
I
S
F
V
K
--
N
S
K
--
T
A
M
D
R
E
E
G
L
K
I
G
L
S
D
D
--
S
----
N
K
-----
I
E
A
--
I
--
Y
Y
C--
D
------
S
N
Y
D
--
K
A
Y
D
G
T
V
E
L
L
---
T
K
Y
P
D
I
---
S
V
M
V
G
L
N
Q
Y
S
A
T
G
A
A
R
A
I
K
D
M
S
L
---
E
--
A
K
V
K
L
V
C
------
I
D
S
S
-----
M
-----
E
Q-----
E
---
G
-
I
F
E
A
M
V
V
Q
K
P
F
N
I
G
Y
L
G
V
E
K
A
L
K
L
L
K
K
E
-
Y
V
P
K
Q
L
D
S
G
C
A
L
I
T
K
D
---------------------------------------
4
PsiBlast_PDB
42.33
22%
-50
- C3 -
1YK1
2
ANPRC_HUMAN
A:
[198-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
L
V
Y
S
D
D
KL
E
-
R
--
N
C
Y
F
T
L
E
G
V
H
E
V
F
Q
E
E
--
G
----
L
H
-----
T
S
I
--
Y
--
S
----
F
------
D
E
T
K
DL
D
L
E
D
I
V
R
N
I
Q
---
A
---
S
E
---
R
V
V
I
M
C
A
S
S
D
T
I
R
S
I
M
L
V
A
H
R
H
G
---
M
--
T
S
G
D
Y
A
F
------
F
N
I
E
-----
L
-----
F
--
N
---
S
---
S
-
S
-
Y
G
D
G
S
W
K
R
G
D
K
H
D
F
E
A
K
Q
A
Y
S
S
L
Q
T
V
-
T
L
L
R
T
V
K
P
E
F
E
K
F
S
M
E
V
K
S
S
V
E
K
Q
-----------------
G
L
N
M
E
D
Y
-
V
N
M
F
V
-
6
PsiBlast_PDB
42.23
22%
-52
- C3 -
1JDP
2
ANPRC_HUMAN
A:
[156-232]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
A
L
V
Y
S
D
D
KL
E
-
R
--
N
C
Y
F
T
L
E
G
V
H
E
V
F
Q
E
E
--
G
----
L
H
-----
T
S
I
--
Y
--
S
----
F
------
D
E
T
K
DL
D
L
E
D
I
V
R
N
I
Q
---
A
---
S
E
---
R
V
V
I
M
C
A
S
S
D
T
I
R
S
I
M
L
V
A
H
R
H
G
---
M
--
T
S
G
D
Y
A
F
------
F
N
I
E
-----
L
-----
F
--
N
---
S
---
S
-
S
-
Y
G
D
G
S
W
K
R
G
D
K
H
D
F
E
A
K
Q
A
Y
S
S
L
Q
T
V
-
T
L
L
R
T
V
K
P
E
F
E
K
F
S
M
E
V
K
S
S
V
E
K
Q
-----------------
G
L
N
M
E
D
Y
-
V
N
M
F
V
-