@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2041: (2015-12-12 )
MMVLERERFMTESDIKVIKRDGRLVSFDKYKIYTALLKASNKVIKMSPLVEAKLEMIADHVIAEIYNRFKDNIKIYEIQNIVEHKLLEANEYAIAQEYINYRTQRDFERSQATDINFSIGKLINKDQTVVNENANKDSDVFNTQRDLTAGIVGKSIGLKMLPSHVANAHQKGDIHYHDLDYSPYTPMTNCCLIDFKGMLANGFKIGNAEVESPKSIQTATAQISQIIANVASSQYGGCTADRIDEFLAPYAQLNYQKHLKDAKEWVIEDKQEDYARAKTQKDIYDAMQSLEYEINTLFTSNGQTPFTSLGFGLGTNWFEREIQKAILKIRIQGLGSEHRTAIFPKLIFTLKKGLNLEEDSPNYDIKQLALECATKRMYPDVLSYDKIIDLTGSFKAPMGCRSFLQGWRDANGQDVTSGRMNLGVVTVNLPRVAMESNGDMDKFWEIFNERMSIARDALVYRVERVKEAIPANAPILYQYGAFGERLGKYDNVDRLFNHRRATVSLGYIGLYEVASVFYGGDWEDNHQAKAFTVDIVRKMKQLCADWSDEYDYHFSVYSTPSESLTDRFCRLDTEKFGIVTDITDKEYYTNSFHYDVRKNPTPFEKLDFEKIYPETGASGGFIHYCEYPVLQQNPKALEAVWDYAYDRVGYLGTNTPIDKCYQCQFEGDFTPTDRGFTCPNCGNSDPKTVDVVKRTCGYLGNPQARPMVNGRHKEISARVKHMNGSSIKNQGN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200..-.....210.......220.......230.-.-.....240.......250.......260.......270.......280.....-----..290.......---------300-------.-.-------......310-....--..------.-320.......330-....-------------...340.......350.........360.......370...-....380.......------390.-----.------.---.--.--...-.400........410--......-..--------420----------..---......430....---------------------.-------------------.--------------------.-440.-..----....450-........460.......470.--...--.--..480.......490......--.500.......510.......520---------------------------------.--------------------------.-------------------------------------.-.------.....530.......540.......550.......560.......570.......--580.----......-----..590.......600........610........620.......630---...-----.....640..-.-----....650.......660..-.....670.......680.......690.......700.......710.......720.......730-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
V
L
E
R
E
RFM
T
E
S
D
I
K
V
I
KRDG
R
L
V
S
F
D
K
Y
K
I
Y
T
A
L
L
K
ASN
K
V
I
K
MS
P
L
V
E
A
K
L
E
M
I
A
D
H
V
I
A
E
I
Y
N
R
F
KDN
I
K
I
Y
E
I
Q
N
I
V
E
H
K
LLEA
N
E
Y
A
I
A
Q
E
Y
I
N
Y
R
T
Q
RDFERSQATDIN
F
S
I
G
K
LINKD
Q
T
V
VNENANKDSDVFNT
Q
R
D
L
T
A
G
I
VGKS
I
G
L
K
M
L
P
S
H
V
ANAHQKGD
I
H
Y
HDLDYSPYTPMT
N
C
C
L
I
D
F
K
G
M
LAN
G
F
K
-IGNAEVESPKS
I
Q
T
A
T
A
Q
I
S
Q
I
I
A
N
V
A
SS-Q-YGGC
T
A
D
R
I
D
E
F
L
A
P
Y
A
Q
L
N
Y
Q
K
H
L
K
D
A
K
E
W
V
IEDK
Q
E
D
Y
A
R
A
K
T
Q
K
D
I
Y
D
A
M
-----
Q
S
L
E
Y
E
I
N
T
L
F
T---------SN--------G-Q-------TPFTSLGFG-LG
T
N
--
W
F
------
E
-
R
E
I
Q
K
A
I
L
K
I
R
IQ-GLGS-------------E
H
R
T
A
I
F
P
K
L
I
F
T
L
--
K
KGLNLEEDSPN
Y
D
I
K
Q
L
A
L
E
C
A
T
K
-RMY
P
D
VLSYD
K
I
I
D------L--T-----G------S---F--K--A
P
M
-
G
C
-
R
S
F
L
Q
G
W
RDA-N--GQDVTS-G
R
--------
M
N
-----------
L
G
---
V
V
T
VNL
P
R
V
AMES---------------------N-------------------G--------------------
D
-
M
D
K
F
-
W
E
----
I
F
N
E
R
M
--
S
I
A
R
D
A
L
V
Y
R
V
E
R
V
K
E
AIPANA--
P
I
L
--
Y
--QYG
A
F
G
E
RLGKYD
N
V
D
R
L
F
NH--R
R
A
T
V
SL
G
Y
I
G
L
Y
E
V
A
S
V
FYGG-----------------------------------D--------------------------W-------------------------------------E-D------NHQA
K
A
F
T
V
D
I
V
R
K
M
K
Q
L
C
ADWSDE
Y
D
Y
H
F
S
V
YSTP
S
E
S
L
T
D
R
F
C
RLDTEKF
G
I
V
--
T
--D----ITDKEY-----YTNS
F
H
Y
DVRKNP-TPFEKL
D
F
E
K
I-YPETGASGG
F
I
H
YCEYPVLQ----QN
P
-----
K
A
L
E
A
V
W
D
Y
A
-
Y
-----
D
RVGYLGTNT
P
I
D
K
C
Y
Q
C
Q
-FEGDFTPTDRGFTCPNCGNSDP
K
T
V
D
V
V
K
R
T
C
GYLGNPQARPMVNGR
H
K
E
I
S
A
R
V
KHMNGSSIKNQGN-
4
PsiBlast_PDB
92.48
52%
-77
- C3 -
1H78
2
NRDD_BPT4
A:
[26-587]
----------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
------------------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
--
T
-----
G
------
S
---
S
V
P
V
--
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
YIGT-----------------
Q
-------------------
F
--------------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
-
N
I
L
V
G
R
-----------------------------------
D
-------------------------------------------------------------------------------
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
-
H
F
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
F
T
---------------------------
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
-----------------------------
72
Fugue
92.40
53%
-74
- C3 -
1H7A
2
NRDD_BPT4
A:
[27-589]
-----------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
-
D
A
L
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
--------
G
-
Q
-------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
--
T
-----
G
------
S
---
S
--
V
P
V
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
---------------------
Y
IGTQ---------------
F
--------------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
I
L
V
-------------------------------------------------------------------------------------------------------------------
G
R
D
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
H
F
I
-
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
F
T
C
G
-
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
R
G
---------------------------
5
PsiBlast_PDB
92.09
52%
-76
- C3 -
1HK8
3
NRDD_BPT4
A:
[26-586]
----------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
--------
G
-
Q
-------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
--
T
-----
G
------
S
---
S
V
P
V
--
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
YIGT-----------------
Q
-------------------
F
--------------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
-
N
I
L
V
G
R
-----------------------------------
D
-------------------------------------------------------------------------------
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
-
H
F
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
F
T
C
G
-
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
------------------------------
45
HHSearch
91.96
53%
-77
- C3 -
1H7B
1
NRDD_BPT4
A:
[26-587]
----------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
-
A
D
A
L
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
--------
G
-
Q
-------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
T
G
S
-----
S
------
V
---
P
--
V
--
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
---------------------
Y
-------------------
I
GTQF----------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
N
-
I
L
V
G
------------------------------------------------------------------------------------------------------------------
R
D
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
H
F
I
-
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
-----------------------------
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
-----------------------------
3
PsiBlast_PDB
91.96
52%
-75
- C3 -
1H7B
1
NRDD_BPT4
A:
[26-587]
----------------------------------------------------------------------------------------------------------------------------------------
D
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
--------
G
-
Q
-------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
--
T
-----
G
------
S
---
S
V
P
V
--
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
YIGT-----------------
Q
-------------------
F
--------------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
-
N
I
L
V
G
R
-----------------------------------
D
-------------------------------------------------------------------------------
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
-
H
F
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
-----------------------------
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
-----------------------------
1
PsiBlast_PDB
91.80
52%
-75
- C3 -
1H79
3
NRDD_BPT4
A:
[27-585]
-----------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
--------
G
-
Q
-------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
--
T
-----
G
------
S
---
S
V
P
V
--
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
YIGT-----------------
Q
-------------------
F
--------------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
-
N
I
L
V
G
R
-----------------------------------
D
-------------------------------------------------------------------------------
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
-
H
F
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
F
T
C
G
-
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
-------------------------------
2
PsiBlast_PDB
91.36
52%
-72
- C3 -
1H7A
2
NRDD_BPT4
A:
[27-589]
-----------------------------------------------------------------------------------------------------------------------------------------
S
R
V
F
P
T
Q
R
D
L
M
A
G
I
V
S
K
H
I
A
K
N
M
V
P
S
F
I
M
K
A
H
E
S
G
I
I
H
V
H
D
I
D
Y
S
P
A
L
P
F
T
N
C
C
L
V
D
L
K
G
M
L
E
N
G
F
K
-
L
G
N
A
Q
I
E
T
P
K
S
I
G
V
A
T
A
I
M
A
Q
I
T
A
Q
V
A
S
H
-
Q
-
Y
G
G
T
T
F
A
N
V
D
K
V
L
S
P
Y
V
K
R
T
Y
A
K
H
I
E
D
A
E
K
W
Q
I
A
D
A
L
-
N
Y
A
Q
S
K
T
E
K
D
V
Y
D
A
F
-----
Q
A
Y
E
Y
E
V
N
T
L
F
S
---------
S
N
--------
G
-
Q
-------
T
P
F
V
T
I
T
F
G
-
T
G
T
D
--
W
T
------
E
-
R
M
I
Q
K
A
I
L
K
N
R
I
K
-
G
L
G
R
-------------
D
G
I
T
P
I
F
P
K
L
V
M
F
V
--
E
E
G
V
N
L
Y
K
D
D
P
N
Y
D
I
K
Q
L
A
L
E
C
A
S
K
-
R
M
Y
P
D
I
I
S
A
K
N
N
K
A
------
I
--
T
-----
G
------
S
---
S
V
P
V
--
S
P
M
-
G
C
-
R
S
F
L
S
V
W
K
D
S
-
T
--
G
N
E
I
L
D
-
G
R
--------
N
N
-----------
L
G
---
V
V
T
L
N
L
P
R
I
A
L
D
S
YIGT-----------------
Q
-------------------
F
--------------------
N
-
E
Q
K
F
-
V
E
----
L
F
N
E
R
M
--
D
L
C
F
E
A
L
M
C
R
I
S
S
L
K
G
V
K
A
T
V
A
--
P
I
L
--
Y
--
Q
E
G
A
F
G
V
R
L
K
P
D
D
D
I
I
E
L
F
K
N
--
G
R
S
S
V
S
L
G
Y
I
G
I
H
E
L
-
N
I
L
V
G
R
-----------------------------------
D
-------------------------------------------------------------------------------
I
G
R
E
I
L
T
K
M
N
A
H
L
K
Q
W
T
E
R
T
G
F
A
F
S
L
Y
S
T
P
A
E
N
L
C
Y
R
F
C
K
L
D
T
E
K
Y
G
S
V
--
K
--
D
----
V
T
D
K
G
W
-----
Y
T
N
S
F
H
V
S
V
E
E
N
I
-
T
P
F
E
K
I
S
R
E
A
P
-
Y
-
H
F
I
A
T
G
G
H
I
S
Y
V
E
L
P
D
M
K
----
N
N
L
-----
K
G
L
E
A
V
W
D
Y
A
-
A
-----
Q
H
L
D
Y
F
G
V
N
M
P
V
D
K
C
F
T
C
G
-
S
T
H
E
M
T
P
T
E
N
G
F
V
C
S
I
C
G
E
T
D
P
K
K
M
N
T
I
R
R
T
C
A
Y
L
G
N
P
N
E
R
G
---------------------------
6
PsiBlast_PDB
65.04
21%
-65
- C3 -
4COI
4
?
A:
[96-623]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
V
I
Q
F
V
M
-
F
A
S
N
-
Q
-
S
S
G
A
V
G
------
L
P
D
F
F
V
W
M
W
Y
F
V
K
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-------
I
E
Q
H
F
-----
Q
I
L
T
Y
S
L
N
Q
P
I
R
---------
T
T
----------
Q
-------
S
P
Y
T
N
F
T
Y
--
L
D
R
N
--
Y
I
K
A
I
F
EG
E
-
R
Y
P
D
G
S
L
I
T
D
H
V
E
-
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
M
F
T
F
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
L
D
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
W
Y
I
S
----
D
S
I
D
A
------
V
--
A
-----
S
------
C
---
C
--
R
-------------------------
E
K
L
K
-
G
R
--------
M
N
SIGGSDLNIGS
F
K
---
V
I
T
V
N
L
P
R
I
A
L
E
S
---------------------
G
-------------------
G
--------------------
D
-
R
E
K
Y
-
L
Q
----
I
L
R
H
R
V
--
Q
L
I
K
K
A
L
A
A
V
R
E
I
I
K
E
R
I
S
E
G
L
--
L
P
L
--
Y
--
E
N
G
L
M
------------
L
L
N
R
--
Q
Y
G
T
I
--
G
V
T
G
V
W
E
S
A
S
I
M
-
G
L
-----------------------------------
T
--------------------------
T
-------------------------------------
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
Y
G
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
V
T
L
A
Q
K
D
R
F
L
F
G
-------
E
----
K
Q
P
F
E
I
-----
Y
S
N
Q
W
-
V
P
L
M
A
N
T
-
D
V
L
N
R
I
R
Y
S
G
K
-
W
D
K
K
V
S
G
G
A
I
L
H
I
N
L
G
E
S
F
K
----
T
E
E
-----
E
S
F
N
M
V
K
M
I
A
-
D
-----
M
G
V
M
Y
F
A
F
N
T
K
I
S
V
C
E
D
G
H
A
F
Y
G
E
--------
R
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
V
P
V
S
A
F
N
K
E
R
R
E
I
E
Y
P
------------------
9
PsiBlast_PDB
64.82
21%
-70
- C3 -
4COL
5
?
A:
[96-623]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
V
I
Q
F
V
M
-
F
A
S
N
-
Q
-
S
S
G
A
V
G
------
L
P
D
F
F
V
W
M
W
Y
F
V
K
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-------
I
E
Q
H
F
-----
Q
I
L
T
Y
S
L
N
Q
P
I
R
---------
T
T
----------
Q
-------
S
P
Y
T
N
F
T
Y
--
L
D
R
N
--
Y
I
K
A
I
F
EG
E
-
R
Y
P
D
G
S
L
I
T
D
H
V
E
-
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
M
F
T
F
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
L
D
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
W
Y
I
S
----
D
S
I
D
A
------
V
--
A
-----
S
----------------------------------------
K
L
K
-
G
R
--------
M
N
SIGGSDLNIGS
F
K
---
V
I
T
V
N
L
P
R
I
A
L
E
S
---------------------
G
-------------------
G
--------------------
D
-
R
E
K
Y
-
L
Q
----
I
L
R
H
R
V
--
Q
L
I
K
K
A
L
A
A
V
R
E
I
I
K
E
R
I
S
E
G
L
--
L
P
L
--
Y
--
E
N
G
L
M
------------
L
L
N
R
--
Q
Y
G
T
I
--
G
V
T
G
V
W
E
S
A
S
I
M
-
G
L
-----------------------------------
T
--------------------------
T
-------------------------------------
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
Y
G
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
V
T
L
A
Q
K
D
R
F
L
F
G
-------
E
----
K
Q
P
F
E
I
-----
Y
S
N
Q
W
-
V
P
L
M
A
N
T
-
D
V
L
N
R
I
R
Y
S
G
K
-
W
D
K
K
V
S
G
G
A
I
L
H
I
N
L
---------
T
E
E
-----
E
S
F
N
M
V
K
M
I
A
-
D
-----
M
G
V
M
Y
F
A
F
N
T
K
I
S
V
C
E
D
G
H
A
F
Y
G
E
--------
R
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
V
P
V
S
A
F
N
---------------------------
8
PsiBlast_PDB
64.18
21%
-69
- C3 -
4COJ
5
?
A:
[96-623]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
V
I
Q
F
V
M
-
F
A
S
N
-
Q
-
S
S
G
A
V
G
------
L
P
D
F
F
V
W
M
W
Y
F
V
K
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-------
I
E
Q
H
F
-----
Q
I
L
T
Y
S
L
N
Q
P
I
R
---------
T
T
----------
Q
-------
S
P
Y
T
N
F
T
Y
--
L
D
R
N
--
Y
I
K
A
I
F
EG
E
-
R
Y
P
D
G
S
L
I
T
D
H
V
E
-
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
M
F
T
F
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
L
D
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
W
Y
I
S
----
D
S
I
D
A
------
V
--
A
-----
S
------
C
---
C
----------------------------
E
K
L
K
-
G
R
--------
M
N
SIGGSDLNIGS
F
K
---
V
I
T
V
N
L
P
R
I
A
L
E
S
---------------------
G
-------------------
G
--------------------
D
-
R
E
K
Y
-
L
Q
----
I
L
R
H
R
V
--
Q
L
I
K
K
A
L
A
A
V
R
E
I
I
K
E
R
I
S
E
G
L
--
L
P
L
--
Y
--
E
N
G
L
M
------------
L
L
N
R
--
Q
Y
G
T
I
--
G
V
T
G
V
W
E
S
A
S
I
M
-
G
L
-----------------------------------
T
--------------------------
T
-------------------------------------
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
Y
G
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
V
T
L
A
Q
K
D
R
F
L
F
G
-------
E
----
K
Q
P
F
E
I
-----
Y
S
N
Q
W
-
V
P
L
M
A
N
T
-
D
V
L
N
R
I
R
Y
S
G
K
-
W
D
K
K
V
S
G
G
A
I
L
H
I
N
L
----
K
----
T
E
E
-----
E
S
F
N
M
V
K
M
I
A
-
D
-----
M
G
V
M
Y
F
A
F
N
T
K
I
S
V
C
E
D
G
H
A
F
Y
G
E
--------
R
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
V
P
V
S
A
F
N
K
E
R
------------------------
7
PsiBlast_PDB
61.82
21%
-70
- C3 -
4CON
1
?
A:
[96-588]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
V
I
Q
F
V
M
-
F
A
S
N
-
Q
-
S
S
G
A
V
G
------
L
P
D
F
F
V
W
M
W
Y
F
V
K
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-------
I
E
Q
H
F
-----
Q
I
L
T
Y
S
L
N
Q
P
------------
T
----------
Q
-------
S
P
Y
T
N
F
T
Y
--
L
D
R
N
--
Y
I
K
A
I
F
EG
E
-
R
Y
P
D
G
S
L
I
T
D
H
V
E
-
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
M
F
T
F
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
L
D
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
W
Y
I
S
----
D
S
I
D
A
------
V
--
A
---------------------------------------------
E
K
L
K
-
G
R
--------
M
N
SIGGSDLNIGS
F
K
---
V
I
T
V
N
L
P
R
I
A
L
E
S
---------------------
G
-------------------
G
--------------------
D
-
R
E
K
Y
-
L
Q
----
I
L
R
H
R
V
--
Q
L
I
K
K
A
L
A
A
V
R
E
I
I
K
E
R
I
S
E
G
L
--
L
P
L
--
Y
--
E
N
G
L
M
------------
L
L
N
R
--
Q
Y
G
T
I
--
G
V
T
G
V
W
E
S
A
S
I
M
-
G
L
-----------------------------------
T
--------------------------
T
-------------------------------------
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
Y
G
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
V
T
L
A
Q
K
D
R
F
L
F
G
-------
E
----
K
Q
P
F
E
I
-----
Y
S
N
Q
W
-
V
P
L
M
A
N
T
-
D
V
L
N
R
I
R
Y
S
G
K
-
W
D
K
K
V
S
G
G
A
I
L
H
I
N
-----
K
----
T
E
E
-----
E
S
F
N
M
V
K
M
I
A
-
D
-----
M
G
V
M
Y
F
A
F
N
--------------------------------------------------------------------------------
46
HHSearch
47.40
14%
-46
- C3 -
1R9D
1
?
A:
[252-786]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
G
E
G
A
K
S
F
Y
E
A
C
Q
L
F
W
F
I
H
A
I
I
N
I
E
-
S
N
G
H
S
I
S
P
A
R
F
D
Q
Y
M
Y
P
Y
Y
E
N
D
K
---------------------
N
I
T
D
K
F
A
Q
E
L
I
-----
D
C
I
W
I
K
L
N
D
I
N
K
V
--------
R
D
--------
E
I
S
T
K
H
F
GGY
P
M
Y
Q
N
L
I
V
G
G
Q
N
S
E
GK
D
A
------
T
-
N
K
V
S
Y
M
A
L
E
A
A
V
H
-
V
-------------------
K
L
P
Q
P
S
L
S
V
R
I
--
W
N
K
---
T
P
D
E
----
F
L
L
R
A
A
E
L
T
R
E
G
L
G
L
P
A
Y
Y
N
D
E
V
I
I
P
A
L
V
S
R
G
L
--
T
-----
L
------
E
D
A
R
D
--
Y
--
G
I
I
-
G
C
-
V
E
P
Q
K
P
----------
G
K
---
T
E
--------
G
W
-----------
H
D
---
S
A
F
F
N
L
A
R
I
V
E
L
T
---------------------
I
-------------------
N
SGFDKNKQIGPKTQNFEEMK
S
-
F
D
E
F
-
M
K
A
Y
K
A
Q
M
E
Y
F
V
--
K
H
M
C
C
A
D
N
C
I
D
I
A
H
A
E
R
A
P
L
----
P
F
L
--
S
S
M
V
D
N
C
I
G
----
K
G
K
S
L
---
Q
D
G
GA
E
Y
N
F
S
G
P
Q
G
V
G
V
A
N
I
G
D
S
L
V
A
V
-----------------------------------
K
K
-------------------------
I
VFDENKIT
P
S
E
L
K
K
T
L
N
N
DFKNS
E
E
I
Q
A
L
L
K
N
APKFG
N
-
D
------
I
D
E
V
D
N
L
A
R
E
G
A
L
V
Y
C
R
E
V
N
K
Y
T
N
P
R
G
G
N
F
Q
P
G
L
Y
P
S
S
I
--
N
V
Y
F
G
S
L
T
G
A
T
P
D
G
--
R
KS
G
QPLA
D
G
V
S
P
S
-----
R
G
C
D
V
S
G
--------
P
T
A
A
C
N
S
V
S
K
L
D
H
F
I
-
A
S
N
G
T
L
F
N
Q
K
F
H
P
S
A
LKG
D
N
G
L
-----
M
N
L
S
S
L
I
R
S
Y
F
D
-----
Q
K
G
F
H
V
Q
F
N
V
I
---
D
K
K
-
I
-
L
L
A
A
Q
-------
K
N
P
E
K
Y
Q
D
------
L
I
V
R
V
A
G
Y
S
A
Q
F
-
I
-
S
L
D
K
S
I
Q
N
D
I
I
A
R
T
E
H
V
M
----------
48
HHSearch
45.78
13%
-34
* C3 *
2F3O
2
?
A:
[242-775]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
A
E
K
P
E
T
F
W
E
A
V
Q
F
V
W
L
V
Q
S
A
L
H
Q
E
N
Y
-
E
Q
A
I
S
M
G
R
I
D
Q
Y
L
Y
P
F
F
K
K
D
I
G
E
G
------------------
R
I
N
R
E
L
A
F
D
I
L
-----
A
N
L
W
I
K
T
N
E
I
V
P
AFD
S
L
L
E
Q
Y
F
S
--------
G
-
Q
-------
A
T
N
Q
A
V
T
I
G
-
G
C
D
I
YG
N
D
------
A
T
N
E
L
T
Y
L
M
L
E
V
T
D
R
-
L
------------------
R
L
R
Q
-
P
N
V
H
V
R
I
--
N
K
G
---
S
P
E
S
----
F
L
K
R
L
A
E
A
I
S
S
G
C
N
N
L
A
L
F
F
D
D
A
A
V
K
A
L
K
---
N
--
A
-----
E
VD
D
R
D
A
L
---
N
--
Y
--
T
T
D
-
G
C
-
V
--------------
E
I
A
P
F
-
G
N
SF------
T
S
-----------
S
D
---
A
A
L
I
N
V
A
K
A
L
E
Y
A
---------------------
L
N
E
GVDLQFGYEFGAKTEKP
K
--------------------
F
-
L
E
D
L
-
L
E
K
L
R
E
Q
V
S
H
I
V
--
K
L
V
V
R
G
S
N
----
V
L
S
Y
A
N
A
E
V
K
PT
P
L
L
S
L
C
--
V
E
D
C
F
E
K
G
----
V
D
V
---
S
R
G
GA
R
Y
N
F
T
G
I
Q
A
V
G
I
A
D
V
G
D
S
L
V
A
I
E
G
A
L
N
A
GYS
M
D
D
I
V
E
A
C
R
K
NFVGY
E
K
L
H
K
L
L
L
Q
SP
K
--------------------------
Y
-------------------------------------
G
N
D
------
D
D
A
A
D
K
Y
T
K
M
V
L
E
W
Y
C
E
E
V
N
R
H
R
N
F
R
G
G
K
F
A
A
G
C
Y
P
M
T
T
-------
N
--
V
G
F
G
F
F
--
T
--
S
----
A
L
P
S
G
R
KSGEP
L
N
P
G
V
S
P
S
T
G
M
D
R
E
G
V
T
A
V
I
N
S
A
S
K
L
S
Y
E
N
-
L
P
N
G
A
S
L
T
I
N
L
S
S
D
V
LGE-
K
G
D
-----
A
V
I
E
A
L
I
K
S
S
M
E
-----
L
G
V
M
H
V
Q
F
N
I
L
K
E
--------
D
L
---
L
R
K
-
A
Q
Q
E
P
E
K
Y
---
R
W
---
L
L
V
R
V
A
G
W
S
A
Y
F
V
--
E
L
S
R
P
V
Q
E
E
V
I
R
R
I
S
C
R
I
----------
10
PsiBlast_PDB
43.60
21%
5
- C3 -
4U3E
6
?
A:
[116-643]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
V
A
D
E
F
V
E
A
Q
I
N
G
A
V
Y
L
H
D
R
H
H
A
A
L
M
P
Y
--
C
F
A
Y
T
L
K
P
I
V
E
K
G
L
P
F
I
K
T
I
K
S
E
P
A
K
H
L
S
T
F
I
Q
H
V
I
Q
F
V
M
-
F
A
S
N
-
Q
-
S
S
G
A
V
G
------
L
P
D
F
F
V
W
M
W
Y
F
V
K
K
D
L
K
E
G
I
I
P
R
D
K
L
D
W
Y
-------
I
E
Q
H
F
-----
Q
I
L
T
Y
S
L
N
Q
P
I
R
---------
T
T
----------
Q
-------
S
P
Y
T
N
F
T
Y
--
L
D
R
N
--
Y
I
K
A
I
F
EG
E
-
R
Y
P
D
G
S
L
I
T
D
H
V
E
-
D
I
I
A
L
Q
K
H
Y
W
E
W
V
S
R
E
R
E
R
Q
M
F
T
F
P
V
L
T
A
S
L
L
Y
K
D
G
K
F
L
D
E
D
S
A
R
F
-
I
N
K
I
N
M
K
W
Q
D
T
-
N
W
Y
I
S
----
D
S
I
D
A
------
V
--
A
-----
S
------
C
--------------------------------
E
K
L
K
-
G
R
M
N
SIGGSD
L
N
-----------
I
G
SF
K
V
I
T
V
N
L
P
R
I
A
L
E
S
---------------------
G
-------------------
G
--------------------
D
-
R
E
K
Y
-
L
Q
----
I
L
R
H
R
V
--
Q
L
I
K
K
A
L
A
A
V
R
E
I
I
K
E
R
I
S
E
G
L
--
L
P
L
--
Y
--
E
N
G
L
------------
M
L
L
N
R
--
Q
Y
G
T
I
--
G
V
T
G
V
W
E
S
A
S
I
-
M
G
L
-----------------------------------
T
--------------------------
T
-------------------------------------
E
-
D
ID
G
L
K
Y
T
E
E
G
E
V
F
V
D
N
V
L
D
T
I
R
E
E
A
E
K
G
Y
H
E
Y
G
F
T
F
N
I
E
Q
V
P
A
E
K
A
A
V
T
L
A
Q
K
D
R
F
L
F
G
-------
E
----
K
Q
P
F
E
I
-----
Y
S
N
Q
W
-
V
P
L
M
A
N
T
-
D
V
L
N
R
I
R
Y
S
G
K
-
W
D
K
K
V
S
G
G
A
I
L
H
I
N
L
G
E
S
F
K
----
T
E
E
-----
E
S
F
N
M
V
K
M
I
A
-
D
-----
M
G
V
M
Y
F
A
F
N
T
K
I
S
V
C
E
D
G
H
A
F
Y
G
E
--------
R
C
P
V
C
G
K
A
K
---
V
D
E
Y
M
R
I
V
G
Y
L
V
P
V
S
A
F
N
K
E
R
R
E
I
E
Y
P
R
R
Q
F
Y
D
S
L
T
I
R
-------
47
HHSearch
43.22
12%
-41
- C3 -
1H16
9
PFLB_ECOLI
A:
[233-757]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
E
M
A
A
K
-
Y
G
Y
D
I
S
G
P
A
T
N
A
Q
E
A
I
Q
W
T
Y
F
G
Y
L
A
A
V
K
S
Q
N
-
G
A
A
M
S
F
G
R
T
S
T
F
L
D
V
Y
I
E
R
D
L
K
A
G
------------------
K
I
T
E
Q
E
A
Q
E
M
V
-----
D
H
L
V
M
K
L
R
M
V
R
F
L
--------
R
T
P
E
Y
D
E
L
F
S
G
-
D
-------
P
I
W
A
T
E
S
I
G
G
M
G
L
D
GR
T
L
------
V
-
T
K
N
S
F
R
F
L
N
T
L
Y
T
M
G
-------------------
P
S
P
E
P
N
M
T
I
L
W
--
S
E
K
---
L
P
L
N
----
F
K
K
F
A
A
K
V
S
I
D
-
T
S
S
L
Q
Y
E
N
D
D
L
M
R
P
D
-----
F
--
N
-----
N
------
D
---
D
--
Y
--
A
I
A
-
C
C
-
V
S
P
M
I
V
--------
G
K
Q
--------------
M
Q
-----------
F
F
---
G
A
R
A
N
L
A
K
T
M
L
Y
A
I
N
GGVDEKLKMQVGPKSEPIK
G
DV-----------------
L
--------------------
N
-
Y
D
E
V
-
M
E
----
R
M
D
H
F
M
--
D
W
L
A
K
Q
Y
I
T
A
L
N
I
I
H
Y
M
H
D
K
Y
S
YE
A
S
L
--
M
----
A
L
H
D
------
R
D
----
V
I
R
--
T
---
M
A
C
G
I
A
G
L
S
V
A
A
D
S
L
S
A
I
-----------------------------------
K
Y
A
K
V
K
P
I
R
D
EDGLAI
D
F
E
I
E
G
E
Y
P
Q
F
G
-------------------------------------
N
-
N
------
D
P
R
V
D
D
L
A
V
D
L
V
E
R
F
M
K
K
I
Q
K
L
H
T
Y
R
D
A
I
P
T
Q
S
V
L
T
I
T
S
--
N
V
V
Y
G
K
K
T
G
N
T
P
D
G
RR
A
--
G
APFG
P
G
A
N
P
M
-----
H
G
R
D
Q
K
--------
G
A
V
A
S
L
T
S
V
A
K
L
P
F
A
Y
-
A
K
D
G
I
S
Y
T
F
S
I
V
P
N
A
L---
G
K
D
D
E
V
R
K
T
N
L
A
G
L
M
D
G
Y
F
H
HEASI
E
G
G
Q
H
L
N
V
N
V
M
---
N
R
E
M
L
-
L
D
A
M
E
--------
N
P
E
K
Y
P
Q
------
L
T
I
R
V
S
G
Y
A
V
R
F
-
N
-
S
L
T
K
E
Q
Q
Q
D
V
I
T
R
T
F
T
Q
S
M
---------
58
HHSearch
41.56
22%
-134
- C3 -
2XAP
-
RIR1_ECOLI
A:
[4-64]
-------------
N
L
L
V
T
K
R
D
G
S
T
E
R
I
N
L
D
K
I
H
R
V
L
D
W
A
A
E
G
L
H
N
---
V
---
S
I
S
Q
V
E
L
R
S
H
I
Q
F
Y
----
D
G
I
K
T
S
D
I
H
E
T
I
I
K
A
A
A
D
L
I
S
R
D
A
P
D
Y
Q
Y
L
A
A
R
L
A
I
F
H
L
R
K
K
A
Y
G
Q
F
E
P
P
A
L
Y
D
H
V
V
K
M
V
E
M
G
K
Y
D
N
H
L
L
E
D
Y
T
E
E
E
F
K
Q
M
D
T
F
I
D
H
D
R
D
M
T
F
S
Y
A
A
V
K
Q
L
E
G
K
Y
L
V
Q
N
R
V
T
G
E
I
Y
E
S
A
Q
F
L
Y
I
L
V
A
A
C
L
F
S
N
Y
-
P
R
E
T
R
L
Q
Y
V
K
R
F
Y
D
A
V
S
T
F
K
I
S
L
P
T
P
I
M
S
-
G
-
V
R
T
P
T
R
Q
F
S
S
C
V
L
I
E
C
G
D
S
L
D
S
I
N
A
T
S
S
A
I
V
K
Y
V
S
Q
R
A
G
I
G
I
N
A
G
R
I
R
A
L
G
S
P
-----
F
H
T
G
C
I
P
F
Y
K
H
F
---------
Q
T
--------
A
-
V
-------
K
S
C
S
Q
G
G
V
R
-
G
G
A
A
--
T
L
------
F
-
Y
P
M
W
H
L
E
V
E
S
L
L
V
-
L
K
N
N
-------------
R
G
V
E
G
N
R
V
R
H
M
D
Y
G
--
V
Q
I
N
K
L
M
Y
T
R
L
L
K
G
E
D
I
T
L
F
S
P
S
D
V
-
P
G
L
Y
D
A
F
F
A
D
Q
E
E
F
------
E
--
R
-----
L
------
Y
---
T
--
K
--
Y
E
K
-
D
D
-
S
I
R
K
Q
R
V
K
A
V
-
E
--
L
F
S
L
M
M
-
Q
E
--------
R
A
-----------
S
T
---
G
R
I
Y
I
Q
N
V
D
H
C
N
T
---------------------
H
-------------------
S
--------------------
P
-
F
D
P
A
-
I
A
----
P
V
R
Q
S
N
--
L
C
L
E
I
A
L
P
T
K
P
L
N
D
V
N
D
E
N
G
E
I
--
A
L
C
--
T
--
L
S
A
F
N
L
G
A
I
N
N
L
D
E
L
E
E
L
A
I
L
--
A
V
R
A
L
D
A
L
L
D
Y
Q
D
Y
P
I
P
A
A
K
R
G
-----------------------------------
A
--------------------------
M
-------------------------------------
G
-
R
------
R
T
L
G
I
G
V
I
N
F
A
Y
Y
L
A
K
H
G
K
R
Y
S
D
G
S
A
N
N
L
T
H
K
T
F
E
A
I
Q
Y
Y
L
L
K
A
S
N
E
L
A
K
E
Q
G
A
C
--
P
--
W
----
F
N
E
T
T
Y
-----
A
K
G
I
L
P
I
D
T
Y
K
K
D
-
L
D
T
I
A
N
E
P
L
H
Y
-
D
W
E
A
L
R
E
S
I
K
T
H
G
L
R
N
S
T
L
S
----
A
L
M
-----
P
S
E
T
S
S
Q
I
S
N
-
A
-----
T
N
G
I
E
P
P
R
G
Y
V
S
I
K
A
S
K
D
G
-
I
L
R
Q
V
V
P
D
Y
E
H
L
H
D
A
Y
E
L
L
W
E
M
P
G
N
D
G
Y
L
Q
L
V
G
I
M
Q
K
F
I
D
Q
S
I
S
A
N
T
N
Y
D
P
S
R
F
P
S
G
K
V
P
M
Q
Q
L
L
K
D
L
-
78
Fugue
40.33
18%
-20
- C1 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
-----------
Q
S
Q
L
K
L
L
V
T
R
G
K
E
Q
G
Y
L
T
Y
A
E
V
N
D
H
L
P
E
D
---
I
V
D
S
D
Q
I
E
D
I
I
Q
M
I
N
D
M
G
I
-
Q
V
M
G
R
T
T
D
P
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
---
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
------------------------------------------------------------
L
S
D
L
I
T
G
F
-------
V
D
D
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
T
-
I
-----
K
A
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
F
R
L
V
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
VEQC
K
M
P
K
K
N
F
I
T
L
F
T
---------
G
N
--------
E
-
T
-------
S
D
-----------
T
--
W
F
------
N
-
A
A
I
A
M
-------
N
-
K
P
W
S
-------------
E
K
L
H
D
V
S
E
E
V
H
R
A
L
--
Q
K
L
Q
Q
I
E
E
E
T
G
---------------------
L
T
I
E
Q
V
K
D
------
I
--
N
-----
R
------
R
---
M
--
S
I
-
G
E
A
-
K
A
-
R
R
A
K
K
E
M
V
E
A
-
N
--
L
R
L
V
I
S
-
I
A
--------
K
K
-----------
Y
T
---
N
R
G
L
Q
F
L
D
L
I
Q
E
G
---------------------
N
-------------------
I
--------------------
G
-
L
M
K
A
-
V
D
----
K
F
E
Y
R
R
GY
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
--
R
T
I
--
R
--
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
L
Q
--
E
M
------------------
G
R
-----------------------------------
E
--------------------------
P
-------------------------------------
T
-
P
------
E
E
L
A
E
R
M
L
M
---------------------------
P
E
D
K
I
R
K
V
L
K
I
A
K
E
P
I
S
M
E
--
T
--
P
----
I
G
D
D
E
--------
D
S
H
L
G
D
F
I
E
D
T
-
T
L
E
---------------------------
L
P
----
L
D
S
-----
A
T
T
E
S
L
R
A
A
T
-
H
-----
D
V
L
A
G
L
--
T
A
R
E
A
K
V
L
R
M
R
-
F
G
I
D
M
-------------
N
T
D
Y
T
L
E
E
V
G
K
Q
------
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
H
P
S
R
S
E
V
L
R
S
F
L
D
60
HHSearch
37.72
13%
-49
- C3 -
1PEQ
-
RIR3_SALTY
A:
[348-510]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
F
F
Q
T
L
A
E
I
Q
F
E
-
S
G
Y
P
Y
I
M
F
E
D
T
V
N
R
------
A
--
N
PIA--
G
------
R
---
I
--
N
--
M
S
N
L
C
S
-
E
I
L
Q
V
N
S
A
S
R
Y
D
DN
L
D
Y
T
H
I
G
H
D
--------
I
S
-----------
C
N
---
L
G
S
L
N
I
A
H
V
M
D
S
-----------------------------------------------------------------------
P
----
D
I
G
R
T
V
--
E
T
A
I
R
G
L
T
A
V
S
D
M
S
--
H
I
---
R
--
S
V
---
P
--
S
---
I
A
-
A
--------
G
N
A
A
S
--
H
--
A
I
G
L
G
Q
M
N
L
H
G
Y
L
A
-
R
E
G
I
-----------------------------------
A
----------------------------------------------------------------
Y
-
G
------
S
P
E
A
L
D
F
T
N
L
Y
F
Y
T
I
T
W
H
A
V
H
T
S
M
R
L
A
R
E
R
G
K
T
F
A
G
F
A
Q
S
R
Y
A
S
G
D
Y
F
T
Q
Y
L
Q
D
D
--
W
--
Q
----
P
K
T
A
K
V
-----
R
A
L
F
A
R
S
G
I
T
L
P
T
-
R
E
M
W
L
K
L
R
D
D
V
-
M
R
Y
G
I
Y
N
Q
N
L
Q
A
V
P
P
T
G
S
I
S
----
Y
I
N
-----
H
A
T
S
S
I
H
P
I
V
-
A
-----
K
I
E
I
R
K
E
G
K
T
G
R
V
Y
Y
P
A
P
F
-
M
T
N
E
N
L
D
M
Y
Q
D
A
Y
D
I
G
P
E
K
I
I
D
T
Y
A
E
A
T
R
H
V
D
Q
G
L
S
L
T
L
F
F
P
D
T
A
T
T
R
D
I
N
K
A
Q
I
Y
A
W
R
K
G
I
K
S
L
Y
Y
I
-
51
HHSearch
37.44
17%
-63
- C3 -
3K8T
2
RIR1_YEAST
A:
[386-549]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
L
W
Y
S
I
L
E
A
Q
T
E
-
T
G
T
P
F
V
V
Y
K
D
A
C
N
R
------
K
--
S
NQKNL
G
------
V
---
I
--
K
--
S
S
N
-
L
C
C
E
I
V
E
Y
-----------
S
A
P
D
-
E
T
--------
A
V
-----------
C
N
---
L
A
S
V
A
L
P
A
F
I
E
-----------------------------------------------------------------K
T
S
T
Y
N
F
K
----
K
L
H
E
I
A
--
K
V
V
T
R
N
L
N
R
V
I
D
R
N
------
Y
Y
--
P
V
------
E
------------
E
A
R
K
S
N
M
R
--
H
R
-
P
I
A
L
G
V
Q
G
L
A
D
T
F
M
-
L
L
R
L
-----------------------------------
P
--------------------------
F
---------------------------------------
D
------
S
E
E
A
R
L
L
N
I
Q
I
F
E
T
I
Y
H
A
S
M
E
A
S
C
E
L
A
Q
K
D
G
P
Y
E
T
F
Q
G
S
P
A
S
Q
G
I
L
Q
F
D
M
W
D
Q
K
P
--
Y
--
G
----
M
W
D
W
D
T
-----
L
R
K
D
I
M
K
H
G
V
R
N
S
-
L
T
M
A
P
M
P
T
A
S
T
-
S
Q
I
L
G
Y
N
E
C
F
E
P
V
T
S
N
M
Y
Q
V
----
V
N
P
-----
Y
L
L
R
D
L
V
D
L
G
-
I
-----
W
D
E
G
M
K
Q
Y
L
I
T
Q
N
G
S
I
Q
G
L
-
P
N
V
P
Q
E
L
K
D
L
Y
K
T
V
W
E
I
S
Q
K
T
I
I
N
M
A
A
D
R
S
V
Y
I
D
Q
S
H
S
L
N
L
F
L
R
A
P
T
M
G
K
L
T
S
M
H
F
Y
G
W
K
K
G
L
K
T
G
M
Y
-
56
HHSearch
37.18
11%
-65
- C3 -
2WGH
1
RIR1_HUMAN
A:
[314-473]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
L
W
Y
A
I
I
E
S
Q
T
E
-
T
G
T
P
Y
M
L
Y
K
D
S
C
N
R
------
K
--
S
-----
N
QQNLG-
T
---
I
--
K
--
C
S
N
L
C
T
-
E
I
V
E
Y
T
S
---------
K
D
---
E
V
--------
A
V
-----------
C
N
---
L
A
S
L
A
L
N
M
Y
V
T
S
E
---------------------
H
--------------------------------------------
T
Y
D
F
K
----
K
L
A
E
V
T
--
K
V
V
V
R
N
L
N
K
I
I
D
I
------
N
Y
Y
--
P
V
------
P
------------
E
A
C
L
S
N
K
R
--
H
R
-
P
I
G
I
G
V
Q
G
L
A
D
A
F
I
-
L
M
R
Y
-----------------------------------
P
----------------------------------------------------------------
F
-
E
------
S
A
E
A
Q
L
L
N
K
Q
I
F
E
T
I
Y
Y
G
A
L
E
A
S
C
D
L
A
K
E
Q
G
P
Y
E
T
Y
E
G
S
P
V
S
K
G
I
L
Q
Y
D
M
W
N
V
T
P
--
T
--
D
----
L
W
D
W
K
V
-----
L
K
E
K
I
A
K
Y
G
I
R
N
S
-
L
L
I
A
P
M
P
T
A
S
T
-
A
Q
I
L
G
N
N
E
S
I
E
P
Y
T
S
N
I
Y
Q
I
----
V
N
P
-----
H
L
L
K
D
L
T
E
R
G
-
L
-----
G
S
I
Q
S
I
P
E
I
P
D
D
L
K
Q
L
Y
K
T
-
V
W
E
I
S
Q
K
T
V
L
K
M
A
A
E
R
G
A
F
I
D
Q
S
Q
S
L
N
I
H
I
A
E
P
N
Y
G
K
L
T
S
M
H
F
Y
G
W
K
Q
G
L
K
T
G
M
Y
Y
L
R
T
R
---------