@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2056: (2015-12-12 )
MDTKHLIASEIQKVVPDMEQSTILSLLETPKNSSMGDLAFPAFSLAKTLRKAPQIIASDIAEQIKSDQFEKVEAVGPYVNFFLDKAAISSQVLKQVLSDGSAYATQNIGEGRNVAIDMSSPNIAKPFSIGHLRSTVIGDSLANIFDKIGYHPVKINHLGDWGKQFGMLIVAYKKWGNEEAVRAHPIDELLKLYVRINAEAETDPSVDEEAREWFRKLEANDPEATELWQWFRDESLLEFNRLYDQMNVTFDSYNGEAFYNDKMDEVLELLESKNLLVESKGAQVVNLEKYGIEHPALIKKSDGATLYITRDLAAALYRKRTYDFAKSIYVVGNEQSAHFKQLKAVLKEMDYDWSDDMTHVPFGLVTKGGAKLSTRKGNVILLEPTVAEAINRAASQIEAKNPNLADKDKVAQAVGVGAIKFYDLKTDRTNGYDFDLEAMVSFEGETGPYVQYAHARIQSILRKANFNPSNSDNYSLNDVESWEIIKLIQDFPRIIVRAADNFEPSIIAKFAINLAQCFNKYYAHTRILDEDAEISSRLALCYATATVLKESLRLLGVDAPNEM
Atome Classification :
(20 SA)
------------------------------------------------------------------.......----------..10.......---.20-........30.........40.-........50----..-----.......60....---.--..-.-70......-..80........90........100.......110.......120.......130.......140.......150.......160.......170....----------...180---------.........190-.......200------..-------......210.......---220.......230.......240.....------...250.--......--..--260..--....-...270.......-----.-----280---.........290--.---.-.--.....-.300.......310.....--------.------------.320----------------------------.----------------.-----------------...-----------..330.......340.......350-..-.-------------------.----.-...360.-..-.--...--370.........380.........390.....----.---.400---.----.-...-..--410.---------......420.......430.......440.-.....--.450.......460..-----.--..------.----.----470--.----.--------....---...480.......490.......-------500.......---510.......520-------.-..-------....-530------.-.--------..-..-------...540.......550.......560.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------MD
T
K
H
L
I
----------
A
S
E
I
Q
K
VVPD
M
---
E
Q
S
-
T
I
L
S
L
L
ETP-KNSSMGDLA
F
-
P
-
A
F
S
L
A
K
T
L
R
-----K
A
-----
P
Q
I
I
A
S
D
I
A
E
Q
I
K
---S--D
Q
-
F
-
E
K
V
E
AVG
P
-
Y
V
N
F
F
L
D
K
A
A
I
S
S
Q
V
L
K
Q
V
L
SDGS
A
Y
A
TQNIGEG
R
N
V
A
I
DMSSPNIAKPFSI
G
H
L
R
S
T
V
I
G
D
S
L
A
N
I
F
D
K
IGY
H
P
V
K
I
NHL
G
D
W
G
K
QF
G
M
L
I
V
A
Y
K
KWG----------N
E
E
A-----------VRAH
P
I
D
E
L
L
K
L
-
Y
V
R
INAEAE-------TD-------PSV
D
E
E
A
R
E
W
F
R
K
LEA---NDP
E
A
T
E
L
W
Q
W
F
R
D
E
S
L
L
E
F
N
R
-
L
Y
D
Q
M------
N
V
T
F
--D--SYNG
E
A
--
F
Y--N--D
K
--
M
D
E
V
-
L
E
L
L
-ESK
N
L
L
V
E-----S-----K-----G
A
Q
V
V
N
L
E
KY----G---I-E--HP
A
L
I
-KKSDG
A
T
L
Y
I
T
R
D
L
A
A
A
L
Y
--------
R
------------
K
R
T
Y
----------------------------
D
----------------
F
-----------------
A
K
S
-----------
I
Y
V
VGNEQS
A
H
F
K
Q
L
K
A
V
L
K
EMD-Y-DW-S-------------------D----D-MTHVP
F
G
-
L
V-T--KGG--
A
--
K
L
STRKG
N
V
I
--
L
LEP
T
V
A
E
A
I
N
R
A
A
S
Q
I----E---AKNP---N----L-A
D
K
-
D
K
--
V
A
Q
A
---------VGV
G
A
I
K
F
Y
D
LKTDRTNGYDF
D
L
E
A
M
V
SFE-GETGP--
Y
V
Q
Y
A
H
A
R
I
Q
S
I
L
R
KA-----N--FN------P----S----N----S----D--------NYSL---NDV
E
S
W
E
I
I
K
L
I
Q
D
F
P
R
I
I
V
R
AA-------DNF
E
P
S
I
I
A
K
---
F
A
I
N
L
A
Q
C
F
N
K
Y
Y
-------
A
-HT-------RILD-E--------D-
A
--------
E
I
-
S
S
-------
R
L
A
L
C
Y
A
T
A
T
V
L
K
E
S
L
R
LLGVDAPNEM
2
PsiBlast_PDB
96.94
35%
-90
- C2 -
1F7U
1
SYRC_YEAST
A:
[36-607]
---------------------------------------------------------------------
R
N
Y
I
----------
S
Q
E
L
S
K
I
-
S
G
V
---
D
S
S
-
L
I
F
P
A
L
E
W
T
-
N
T
M
E
R
G
D
L
L
I
-
P
-
I
P
R
L
-
R
I
K
G
-----
A
N
-----
P
K
D
L
A
V
Q
W
A
E
K
F
P
---
C
--
G
D
-
F
L
E
K
V
E
A
N
G
P
-
F
I
Q
F
F
F
N
P
Q
F
L
A
K
L
V
I
P
D
I
L
T
R
K
E
D
Y
G
S
C
K
L
V
E
N
K
K
V
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
G
K
Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
K
D
I
E
E
E
GDSIP
L
E
-------
Q
S
T
N
G
K
A
R
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
K
I
W
K
R
F
R
E
F
S
I
E
K
Y
I
D
-
T
Y
A
R
L
------
N
I
K
Y
--
D
--
V
Y
S
G
E
S
Q-
V
S
--
K
--
E
S
--
M
L
K
A
-
I
D
L
F
-
K
E
K
G
L
T
H
E
-----
D
-----
K
-----
G
A
V
L
I
D
L
T
K
F
----
N
---
K
-
K
L-
G
K
A
I
V
-
Q
K
S
D
G
T
T
L
Y
L
T
R
D
V
G
A
A
M
D
--------
R
------------
Y
E
K
Y
----------------------------
H
----------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
S
Q
Q
D
L
H
A
A
Q
F
F
E
I
L
K
Q
M
G
-
F
-
E
W
-
A
-------------------
K
----
D
-
L
Q
H
V
N
F
G
-
M
V
-
Q
----------
G
M
S
T
R
K
G
T
V
V
--
F
L
D
-
N
I
L
E
E
T
K
E
K
M
H
E
V
----
M
---
K
K
N
E
---
N
K
Y
A
Q
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
I
S
A
V
M
I
Q
D
M
Q
G
K
R
I
N
N
Y
E
F
K
W
E
R
M
L
S
F
E
-
G
D
T
G
P
--
Y
L
Q
Y
A
H
S
R
L
R
S
V
E
R
N
A
-----
S
--
G
I
------
T
----
Q
E
K
W
I
N
----
A
----
D
--------
F
S
L
L
---
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
R
N
A
I
-------
K
T
H
E
P
T
T
V
V
T
---
Y
L
F
K
L
T
H
Q
V
S
S
C
Y
-------
D
-
V
L
-------
W
V
A
G
-
Q
--------
T
-
E
--------
E
L
A
T
A
-------
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
P
V
E
R
M
3
PsiBlast_PDB
96.29
35%
-90
- C2 -
1F7V
-
SYRC_YEAST
A:
[36-607]
---------------------------------------------------------------------
R
N
Y
I
----------
S
Q
E
L
S
K
I
-
S
G
V
---
D
S
S
-
L
I
F
P
A
L
E
W
T
-
N
T
M
E
R
G
D
L
L
I
-
P
-
I
P
R
L
-
R
I
K
G
-----
A
N
-----
P
K
D
L
A
V
Q
W
A
E
K
F
P
---
C
--
G
D
-
F
L
E
K
V
E
A
N
G
P
-
F
I
Q
F
F
F
N
P
Q
F
L
A
K
L
V
I
P
D
I
L
T
R
K
E
D
Y
G
S
C
K
L
V
E
N
K
K
V
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
G
K
Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
K
D
I
E
E
E
GDSIP
L
E
-------
Q
S
T
N
G
K
A
R
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
K
I
W
K
R
F
R
E
F
S
I
E
K
Y
I
D
-
T
Y
A
R
L
------
N
I
K
Y
--
D
--
V
Y
S
G
E
S
Q-
V
S
--
K
--
E
S
--
M
L
K
A
-
I
D
L
F
-
K
E
K
G
L
T
H
E
-----
D
-----
K
-----
G
A
V
L
I
D
L
T
K
F
----
N
---
K
-
K
L-
G
K
A
I
V
-
Q
K
S
D
G
T
T
L
Y
L
T
R
D
V
G
A
A
M
D
--------
R
------------
Y
E
K
Y
----------------------------
H
----------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
S
Q
Q
D
L
H
A
A
Q
F
F
E
I
L
K
Q
M
G
-
F
-
E
W
-
A
-------------------
K
----
D
-
L
Q
H
V
N
F
G
-
M
V
-
Q
----------
G
M
S
T
R
K
G
T
V
V
--
F
L
D
-
N
I
L
E
E
T
K
E
K
M
H
E
V
----
M
---
K
K
N
E
---
N
K
Y
A
Q
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
I
S
A
V
M
I
Q
D
M
Q
G
K
R
I
N
N
Y
E
F
K
W
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F
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-
G
D
T
G
P
--
Y
L
Q
Y
A
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R
L
R
S
V
E
R
N
A
-----
S
--
G
I
------
T
----
Q
E
K
W
I
N
----
A
----
D
--------
F
S
L
L
---
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
R
N
A
I
-------
K
T
H
E
P
T
T
V
V
T
---
Y
L
F
K
L
T
H
Q
V
S
S
C
Y
-------
D
-
V
L
-------
W
V
A
G
-
Q
--------
T
-
E
--------
E
L
A
T
A
-------
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
P
V
E
R
M
43
Fugue
96.27
36%
-87
- C2 -
1F7U
1
SYRC_YEAST
A:
[2-607]
---------------------------------------A
S
T
A
N
M
I
S
Q
L
K
K
LSIAEPAVAKDSHPD
V
N
I
V
D
L
M
----------
R
N
Y
I
S
Q
E
L
S
K
I
SGV
D
S
S
-
L
I
F
P
A
L
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W
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T
M
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D
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G
-----
A
N
-----
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A
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Q
W
A
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---
C
--
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P
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F
F
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A
K
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Y
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K
L
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K
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A
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L
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Y
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D
W
G
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Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
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E
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GDSIP
L
E
-------
Q
S
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A
R
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R
M
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---
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D
-
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------
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A
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D
L
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----
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K
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L
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D
--------
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------------
Y
E
K
Y
-----------------------------H---------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
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Q
Q
D
L
H
A
A
Q
F
F
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M
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F--
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A
-------------------
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----
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-
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Q
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G
-
M
V
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Q
----------
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M
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T
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--
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L
D
N
I
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E
T
K
E
K
M
H
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V
M
----
K
KN
E
N
K
Y
A
---
Q
----
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
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A
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M
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K
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N
Y
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A
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--
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I
------
T
----
Q
----
E
----
K
W
I
N
A
D
--------
F
S
L
L
---
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
R
N
A
I
-------
K
T
H
E
P
T
T
V
V
T
---
Y
L
F
K
L
T
H
Q
V
S
S
C
Y
-------
D
----------------VLWVAGQT
E
-
E
--------
L
A
-
T
A
-------
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
P
V
E
R
M
21
HHSearch
96.07
36%
-86
- C2 -
1F7U
1
SYRC_YEAST
A:
[30-607]
-------------------------------------------------------------------
N
I
V
D
L
M
----------
R
N
Y
I
S
Q
E
L
S
K
I
SGV
D
S
S
-
L
I
F
P
A
L
E
W
T
-
N
T
M
E
R
G
D
L
L
I
-
P
-
I
P
R
L
-
R
I
K
G
-----
A
N
-----
P
K
D
L
A
V
Q
W
A
E
K
F
P
C--
G
--
D
F
-
L
-
E
K
V
E
A
N
G
P
-
F
I
Q
F
F
F
N
P
Q
F
L
A
K
L
V
I
P
D
I
L
T
R
K
E
D
Y
G
S
C
K
L
V
E
N
K
K
V
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
G
K
Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
K
D
I
E
-------
E
E
GDSIPLE
Q
S
T
N
G
K
A
R
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
K
I
W
K
R
F
R
E
F
S
I
E
K
Y
I
D
-
T
Y
A
R
L
------
N
I
K
Y
--
D
--
V
Y
S
G
E
S
--
Q
V
--
S
K
-
E
S
--
M
L
K
A
-
I
D
L
F
-
K
E
K
G
L
T
H
E
-----
D
-----
K
-----
G
A
V
L
I
D
L
T
K
F
----
N
---
K
K
L
--
G
K
A
I
V
-
Q
K
S
D
G
T
T
L
Y
L
T
R
D
V
G
A
A
M
D
--------
R
------------
Y
E
K
Y
----------------------------
H
----------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
S
Q
Q
D
L
H
A
A
Q
F
F
E
I
L
K
Q
M
G
-
F
-
E
W
-
A
-------------------
K
----
D
-
L
Q
H
V
N
F
G
-
M
V
-
Q
----------
G
M
S
T
R
K
G
T
V
V
--
F
L
D
N
I
L
E
E
T
K
E
K
M
H
E
V
M
----
K
---
K
N
E
N
K
Y
A
Q
----
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
I
S
A
V
M
I
Q
D
M
Q
G
K
R
I
N
N
Y
E
F
K
W
E
R
M
L
S
F
E
-
G
D
T
G
P
--
Y
L
Q
Y
A
H
S
R
L
R
S
V
E
R
N
A
-----
S
--
G
I
------
T
----
Q
----
E
K
W
I
N
A
----
D
--------
F
S
L
L
---
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
R
N
A
I
-------
K
T
H
E
P
T
T
V
V
T
---
Y
L
F
K
L
T
H
Q
V
S
S
C
Y
-------
D
-
V
L
-------
W
V
A
G
-
Q
--------
T
E
E
--------
L
A
-
T
A
-------
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
P
V
E
R
M
1
PsiBlast_PDB
94.81
35%
-89
- C2 -
1BS2
1
SYRC_YEAST
A:
[36-607]
---------------------------------------------------------------------
R
N
Y
I
----------
S
Q
E
L
S
K
I
-
S
G
V
---
D
S
S
-
L
I
F
P
A
L
E
W
T
-
N
T
M
E
R
G
D
L
L
I
-
P
-
I
P
R
L
-
R
I
K
G
-----
A
N
-----
P
K
D
L
A
V
Q
W
A
E
K
F
P
---
C
--
G
D
-
F
L
E
K
V
E
A
N
G
P
-
F
I
Q
F
F
F
N
P
Q
F
L
A
K
L
V
I
P
D
I
L
T
R
K
E
D
Y
G
S
C
K
L
V
E
N
K
K
V
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
G
K
Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
K
D
I
E
E
E
GDSIP
L
E
-------
Q
S
T
N
G
K
A
R
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
K
I
W
K
R
F
R
E
F
S
I
E
K
Y
I
D
-
T
Y
A
R
L
------
N
I
K
Y
--
D
--
V
Y
S
G
E
S
Q-
V
S
--
K
--
E
S
--
M
L
K
A
-
I
D
L
F
-
K
E
K
G
L
T
H
E
-----
D
-----
K
-----
G
A
V
L
I
D
L
T
K
F
----
N
---
K
-
K
L-
G
K
A
I
V
-
Q
K
S
D
G
T
T
L
Y
L
T
R
D
V
G
A
A
M
D
--------
R
------------
Y
E
K
Y
----------------------------
H
----------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
S
Q
Q
D
L
H
A
A
Q
F
F
E
I
L
K
Q
M
G
-
F
-
E
W
-
A
-------------------
K
----
D
-
L
Q
H
V
N
F
G
-
M
V
-
Q
----------
G
M
S
T
R
K
G
T
V
V
--
F
L
D
-
N
I
L
E
E
T
K
E
K
M
H
E
V
----
M
---
K
K
N
E
---
N
KYAQ
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
I
S
A
V
M
I
Q
D
M
Q
G
K
R
I
N
N
Y
E
F
K
W
E
R
M
L
S
F
E
-
G
D
T
G
P
--
Y
L
Q
Y
A
H
S
R
L
R
S
V
E
R
N
A
-----
S
--
G
I
------
T
----
Q
E
K
W
I
N
----
A
----
D
--------
F
S
L
L
---
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
R
N
A
I
-------
K
T
H
E
P
T
T
V
V
T
---
Y
L
F
K
L
T
H
Q
V
S
S
C
Y
-------
D
-
V
L
-------
W
V
A
G
-
Q
--------
T
-
E
--------
E
L
A
T
A
-------
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
P
V
E
R
M
5
PsiBlast_PDB
93.90
29%
-88
- C2 -
4Q2T
2
SYRC_HUMAN
A:
[28-607]
---------------------------------------------------------------------
Q
E
V
F
----------
G
H
A
I
K
A
A
Y
P
D
L
---
E
N
P
----
P
L
L
V
T
P
S
Q
Q
A
K
F
G
D
Y
Q
C
N
S
-
A
M
G
I
S
Q
M
L
K
-----
T
K
EQKVN
P
R
E
I
A
E
N
I
T
K
H
L
P
---
D
--
N
E
C
I
-
E
K
V
E
I
A
G
P
G
F
I
N
V
H
L
R
K
D
F
V
S
E
Q
-
L
T
S
L
L
V
N
G
V
Q
L
P
A
--
L
G
E
N
K
K
V
I
V
D
F
S
S
P
N
I
A
K
E
M
H
V
G
H
L
R
S
T
I
I
G
E
S
I
S
R
L
F
E
F
A
G
Y
D
V
L
R
L
N
H
V
G
D
W
G
T
Q
F
G
M
L
I
A
H
L
Q
D
K
F
----------
P
D
Y
L
-----------
T
V
S
P
P
I
G
D
L
Q
V
F
-
Y
K
E
S
K
K
R
F
D
-------
T
E
-------
E
E
F
K
K
R
A
Y
Q
C
V
V
L
L
Q
G
---
K
N
P
D
I
T
K
A
W
K
L
I
C
D
V
S
R
Q
E
L
N
K
-
I
Y
D
A
L
------
D
V
S
L
--
I
--
E
-
R
G
E
S
--
F
Y
--
Q
--
D
R
--
M
N
D
I
-
V
K
E
F
-
E
D
R
G
F
V
Q
V
-----
D
-----
D
-----
G
R
K
I
V
F
V
P
------
G
---
C
-
S
--
I
P
L
T
I
-
V
K
S
D
G
G
Y
T
Y
D
T
S
D
L
A
A
I
K
Q
--------
R
------------
L
F
E
E
----------------------------
K
----------------
A
-----------------
D
M
I
-----------
I
Y
V
V
D
N
G
Q
S
V
H
F
Q
T
I
F
A
A
A
Q
M
I
----
G
W
-
Y
-------------------
D
PKV
T
R
-
V
F
H
A
G
F
G
-
V
V
-
L
G
-
E
D
K
--
K
--
K
F
K
T
R
S
G
E
T
V
--
R
L
M
D
L
L
G
E
G
L
K
R
S
M
D
K
L
----
K
---
E
K
-------------
E
R
-
D
K
--
V
L
T
A
EELN
A
A
Q
T
S
V
A
Y
G
C
I
K
Y
A
D
L
S
R
N
R
L
N
D
Y
I
F
S
F
D
K
M
L
D
D
R
-
G
N
T
A
A
--
Y
L
L
Y
A
F
T
R
I
R
S
I
A
R
L
A
-----
N
--
I
D
E
E
M
L
Q
K
A
----
A
----
R
----
E
----
T
--------
K
I
L
L
---
D
H
E
K
E
W
K
L
G
R
C
I
L
R
F
P
E
I
L
Q
K
I
L
-------
D
D
L
F
L
H
T
L
C
D
---
Y
I
Y
E
L
A
T
A
F
T
E
F
Y
-------
D
-
S
C
-------
Y
C
V
E
-
K
--------
D
-
R
--------
Q
T
-
G
K
ILKVN
M
W
R
M
L
L
C
E
A
V
A
A
V
M
A
K
G
F
D
I
L
G
I
K
P
V
Q
R
M
6
PsiBlast_PDB
90.35
29%
-90
- C2 -
4Q2Y
-
SYRC_HUMAN
A:
[28-607]
---------------------------------------------------------------------
Q
E
V
F
----------
G
H
----
A
Y
P
D
L
---
E
N
P
----
P
L
L
V
T
P
S
Q
---
F
G
D
Y
Q
C
N
S
-
A
M
G
I
S
Q
M
---------------------
I
T
K
H
L
P
---
D
--
N
E
C------
I
A
G
P
G
F
I
N
V
H
L
R
K
D
F
V
S
E
Q
-
L
T
S
L
L
V
N
G
V
Q
L
P
A
--
L
G
E
N
K
K
V
I
V
D
F
S
S
P
N
I
A
K
E
M
H
V
G
H
L
R
S
T
I
I
G
E
S
I
S
R
L
F
E
F
A
G
Y
D
V
L
R
L
N
H
V
G
D
W
G
T
Q
F
G
M
L
I
A
H
L
Q
D
K
F
----------
P
D
Y
L
-----------
T
V
S
P
P
I
G
D
L
Q
V
F
-
Y
K
E
S
K
K
R
F
D
-------
T
E
-------
E
E
F
K
K
R
A
Y
Q
C
V
V
L
L
Q
G
---
K
N
P
D
I
T
K
A
W
K
L
I
C
D
V
S
R
Q
E
L
N
K
-
I
Y
D
A
L
------
D
V
S
L
--
I
--
E
-
R
G
E
S
--
F
Y
--
Q
--
D
R
--
M
N
D
I
-
V
K
E
F
-
E
D
R
G
F
V
Q
V
-----
D
-----
D
-----
G
R
K
I
V
F
V
P
------
G
---
C
-
S
--
I
P
L
T
I
-
V
K
S
D
G
G
Y
T
Y
D
T
S
D
L
A
A
I
K
Q
--------
R
------------
L
F
E
E
----------------------------
K
----------------
A
-----------------
D
M
I
-----------
I
Y
V
V
D
N
G
Q
S
V
H
F
Q
T
I
F
A
A
A
Q
M
I
----
G
W
-
Y
-------------------
D
PKV
T
R
-
V
F
H
A
G
F
G
-
V
V
-
L
G
-
E
D
K
--
K
--
K
F
K
T
R
S
G
E
T
V
--
R
L
M
D
L
L
G
E
G
L
K
R
S
M
D
K
L
----
K
---
E
K
-------------
E
R
-
D
K
--
V
L
T
A
EELN
A
A
Q
T
S
V
A
Y
G
C
I
K
Y
A
D
L
S
R
N
R
L
N
D
Y
I
F
S
F
D
K
M
L
D
D
R
-
G
N
T
A
A
--
Y
L
L
Y
A
F
T
R
I
R
S
I
A
R
L
A
-----
N
--
I
D
E
E
M
L
Q
K
A
----
A
----
R
----
E
----
T
--------
K
I
L
L
---
D
H
E
K
E
W
K
L
G
R
C
I
L
R
F
P
E
I
L
Q
K
I
L
-------
D
D
L
F
L
H
T
L
C
D
---
Y
I
Y
E
L
A
T
A
F
T
E
F
Y
-------
D
-
S
C
-------
Y
C
V
E
-
K
--------
D
-
R
------------
K
ILKVN
M
W
R
M
L
L
C
E
A
V
A
A
V
M
A
K
G
F
D
I
L
G
I
K
P
V
Q
R
M
8
PsiBlast_PDB
90.24
31%
-81
- C2 -
2ZUE
2
SYR_PYRHO
A:
[28-629]
-------------------------------------------------------------------------------------------------------
I
E
L
K
E
T
P
--
D
P
K
L
G
D
F
G
T
-
P
I
A
F
K
L
A
K
L
L
K
-----
R
P
-----
P
I
E
I
A
E
K
I
V
E
K
L
K
L
NL
P
--
E
G
-
I
-
K
D
V
K
A
V
N
G
-
Y
I
N
V
F
I
D
Y
P
H
F
A
R
I
L
I
N
D
I
L
A
K
G
D
R
F
G
S
S
E
I
G
K
G
K
K
V
I
V
E
H
T
S
V
N
P
T
K
P
L
H
M
G
H
A
R
N
A
I
L
G
D
V
M
A
R
I
L
R
F
L
G
Y
E
V
E
V
Q
N
Y
I
D
D
L
G
I
Q
F
A
Q
V
Y
W
G
Y
L
R
L
K
E
E
F
E
R
I
M
N
E
L
R
E
R
G
-----------
L
K
D
N
P
I
D
H
A
L
G
L
L
Y
V
E
V
N
R
R
L
E
-------
D
N
-------
P
E
L
E
N
E
I
R
D
I
M
K
K
L
E
S
---
G
E
L
Y
G
R
K
L
A
E
E
V
V
R
A
Q
M
V
T
T
Y
K
-
L
----------
G
V
K
Y
--
D
--
L
L
V
W
E
S
D
-
I
V
--
R
--
R
K
--
L
F
E
I
A
L
E
L
L
S
K
N
E
N
F
Y
I
P
-----
S
DGKY-
R
-----
G
A
F
V
M
D
L
R
K
L
FP--
D
---
M
-
K
--
N
P
I
L
V
L
R
R
S
D
G
T
A
T
Y
T
G
K
D
I
A
Y
H
L
W
--------
K
------------
F
G
K
I
----------------------------
D
----------------
V
D
L
L
Y
K
E
WDST
T
W
T
T
A
PD
G
K
S
M
P
NKFGNAN
I
V
I
N
V
I
G
A
E
Q
K
H
P
Q
L
A
I
K
Y
A
L
Q
L
L
G
-
F
E
D
A
-
A
-------------------
A
----
N
-
L
Y
H
L
A
Y
E
-
H
V
-
E
--
R
P
E
--
G
--
K
F
S
G
R
K
G
T
W
V
GF
T
V
D
E
V
I
Q
E
A
V
K
R
A
R
E
L
I
----
E
---
E
K
N
P
---
A
----
L
-
S
D
E
-
E
K
A
E
V
A
E
K
---------
V
G
I
G
A
I
R
Y
N
L
I
K
Y
S
P
D
K
K
I
I
F
R
W
E
D
V
L
N
F
E
-
G
E
S
A
P
--
Y
I
Q
Y
A
H
A
R
C
S
S
I
L
R
K
A
E
E
E
GI
K
--
V
D
------
P
E
T
L
F
K
----
N
----
A
----
D
--------
F
T
K
L
---
S
E
R
E
R
-
E
L
V
I
M
L
S
K
F
P
R
I
V
E
Q
A
G
-------
K
D
V
K
P
H
L
I
A
W
---
F
A
N
E
L
A
S
L
F
N
K
F
Y
-------
M
D
H
P
-------
V
L
K
A
-
E
--------
E
-
G
--------
V
R
-
E
A
-------
R
L
L
L
V
M
A
V
E
Q
V
L
K
N
A
L
Y
L
M
G
I
E
A
P
E
R
M
9
PsiBlast_PDB
90.14
31%
-81
- C2 -
2ZUF
-
SYR_PYRHO
A:
[28-629]
-------------------------------------------------------------------------------------------------------
I
E
L
K
E
T
P
--
D
P
K
L
G
D
F
G
T
-
P
I
A
F
K
L
A
K
L
L
K
-----
R
P
-----
P
I
E
I
A
E
K
I
V
E
K
L
K
L
N
L
P
--
E
G
-
I
-
K
D
V
K
A
V
N
G
-
Y
I
N
V
F
I
D
Y
P
H
F
A
R
I
L
I
N
D
I
L
A
K
G
D
R
F
G
S
S
E
I
G
K
G
K
K
V
I
V
E
H
T
S
V
N
P
T
K
P
L
H
M
G
H
A
R
N
A
I
L
G
D
V
M
A
R
I
L
R
F
L
G
Y
E
V
E
V
Q
N
Y
I
D
D
L
G
I
Q
F
A
Q
V
Y
W
G
Y
L
R
L
K
E
E
F
E
R
I
M
N
E
L
R
E
R
G
-----------
L
K
D
N
P
I
D
H
A
L
G
L
L
Y
V
E
V
N
R
R
L
E
-------
D
N
-------
P
E
L
E
N
E
I
R
D
I
M
K
K
L
E
S
---
G
E
L
Y
G
R
K
L
A
E
E
V
V
R
A
Q
M
V
T
T
Y
K
-
L
----------
G
V
K
Y
--
D
--
L
L
V
W
E
S
D
-
I
V
--
R
--
R
K
--
L
F
E
I
A
L
E
L
L
S
K
N
E
N
F
Y
I
P
-----
S
DGKY-
R
-----
G
A
F
V
M
D
L
R
K
L
FP--
D
---
M
-
K
--
N
P
I
L
V
L
R
R
S
D
G
T
A
T
Y
T
G
K
D
I
A
Y
H
L
W
--------
K
------------
F
G
K
I
----------------------------
D
----------------
V
D
L
L
Y
K
E
WDST
T
W
T
T
A
PD
G
K
S
M
P
NKFGNAN
I
V
I
N
V
I
G
A
E
Q
K
H
P
Q
L
A
I
K
Y
A
L
Q
L
L
G
-
F
E
D
A
-
A
-------------------
A
----
N
-
L
Y
H
L
A
Y
E
-
H
V
-
E
--
R
P
E
--
G
--
K
F
S
G
R
K
G
T
W
V
GF
T
V
D
E
V
I
Q
E
A
V
K
R
A
R
E
L
I
----
E
---
E
K
N
P
---
A
----
L
-
S
D
E
-
E
K
A
E
V
A
E
K
---------
V
G
I
G
A
I
R
Y
N
L
I
K
Y
S
P
D
K
K
I
I
F
R
W
E
D
V
L
N
F
E
-
G
E
S
A
P
--
Y
I
Q
Y
A
H
A
R
C
S
S
I
L
R
K
A
E
E
E
GI
K
--
V
D
------
P
E
T
L
F
K
----
N
----
A
----
D
--------
F
T
K
L
---
S
E
R
E
R
-
E
L
V
I
M
L
S
K
F
P
R
I
V
E
Q
A
G
-------
K
D
V
K
P
H
L
I
A
W
---
F
A
N
E
L
A
S
L
F
N
K
F
Y
-------
M
D
H
P
-------
V
L
K
A
-
E
--------
E
-
G
--------
V
R
-
E
A
-------
R
L
L
L
V
M
A
V
E
Q
V
L
K
N
A
L
Y
L
M
G
I
E
A
P
E
R
M
46
Fugue
90.13
30%
-82
- C2 -
4R3Z
-
SYRC_HUMAN
B:
[17-675]
DV
L
V
S
E
C
S
A
R
L
L
Q
Q
E
E
E
I
K
S
L
T
A
E
I
D
R
LKNCGCLGASPNLE
Q
L
Q
E
E
N
L
K
L
K
Y
R
L
N
I
L
R
K
S
L
Q
A
E
R
N
K
P
T
K
N
M
I
N
I
I
S
R
L
Q
E
V
F
G
H
A
I
K
A
A
Y
P
D
L
---
E
N
P
-
P
L
L
--
V
T
P
S
-
Q
Q
A
K
F
G
D
Y
Q
C
-
N
S
A
M
G
I
S
Q
M
L
K
TKE
Q
K
V
N
-----
P
R
E
I
A
E
N
I
T
K
H
L
P
---
D
--
N
E
C
I
-
E
K
V
E
I
A
G
P
G
F
I
N
V
H
L
R
K
D
F
V
S
-
E
Q
L
T
S
L
L
V
N
G
V
Q
L
P
--
A
L
G
E
N
K
K
V
I
V
D
F
S
S
P
N
I
A
K
E
M
H
V
G
H
L
R
S
T
I
I
G
E
S
I
S
R
L
F
E
F
A
G
Y
D
V
L
R
L
N
H
V
G
D
W
G
T
Q
F
G
M
L
I
A
H
L
Q
D
K
F
----------
P
D
Y
L
-----------
T
V
S
P
P
I
G
D
L
Q
V
F
-
Y
K
E
S
K
K
R
F
D
-------
T
E
-------
E
E
F
K
K
R
A
Y
Q
C
V
V
L
L
Q
G
---
K
N
P
D
I
T
K
A
W
K
L
I
C
D
V
S
R
Q
E
L
N
K
-
I
Y
D
A
L
------
D
V
S
L
--
I
--
E
-
R
G
E
S
--
F
Y
--
Q
--
D
R
--
M
N
D
I
-
V
K
E
F
-
E
D
R
G
F
V
Q
V
-----
D
-----
D
-----
G
R
K
I
V
F
V
P
------
G
---
C
-
S
--
I
P
L
T
I
-
V
K
S
D
G
G
Y
T
Y
D
T
S
D
L
A
A
I
K
Q
--------
R
------------
L
F
E
E
----------------------------
K
----------------
A
-----------------
D
M
I
-----------
I
Y
V
V
D
N
G
Q
S
V
H
F
Q
T
I
F
A
A
A
Q
M
I
G
W
Y
-
D
P
-
K
-------------------
V
----
T
R
V
F
H
A
G
F
G
-
V
V
-
L
G
-
E
D
K
--
K
--
K
F
K
T
R
S
G
E
T
V
--
R
L
M
D
L
L
G
E
G
L
K
R
S
M
D
K
L
K
E
KE
R
---
D
K
V
L
---
T
----
A
-
E
E
L
-
N
A
--
A
Q
T
S
---------
V
A
Y
G
C
I
K
Y
A
D
L
S
H
N
R
L
N
D
Y
I
F
S
F
D
K
M
L
D
D
R
-
G
N
T
A
A
--
Y
L
L
Y
A
F
T
R
I
R
S
I
A
R
L
A
-----
N
--
I
D
E
E
M
L
Q
K
A
----
A
----
R
----
E
----
T
--------
K
I
L
L
---
D
H
E
K
E
W
K
L
G
R
C
I
L
R
F
P
E
I
L
Q
K
I
L
-------
D
D
L
F
L
H
T
L
C
D
---
Y
I
Y
E
L
A
T
A
F
T
E
F
Y
-------
D
-
S
C
-------
Y
C
V
E
-
K
--------
D
-
R
--------
Q
T
-
G
K
ILKVN
M
W
R
M
L
L
C
E
A
V
A
A
V
M
A
K
G
F
D
I
L
G
I
K
P
V
Q
R
M
7
PsiBlast_PDB
89.71
29%
-86
- C2 -
4R3Z
-
SYRC_HUMAN
B:
[96-675]
---------------------------------------------------------------------
Q
E
V
F
----------
G
H
A
I
K
A
A
Y
P
D
L
---
E
N
P
----
P
L
L
V
T
P
S
Q
Q
A
K
F
G
D
Y
Q
C
N
S
-
A
M
G
I
S
Q
M
L
K
-----
T
K
E
Q
K
V
N
P
R
E
I
A
E
N
I
T
K
H
L
P
---
D
--
N
E
C
I
-
E
K
V
E
I
A
G
P
G
F
I
N
V
H
L
R
K
D
F
V
S
E
Q
-
L
T
S
L
L
V
N
G
V
Q
L
P
A
--
L
G
E
N
K
K
V
I
V
D
F
S
S
P
N
I
A
K
E
M
H
V
G
H
L
R
S
T
I
I
G
E
S
I
S
R
L
F
E
F
A
G
Y
D
V
L
R
L
N
H
V
G
D
W
G
T
Q
F
G
M
L
I
A
H
L
Q
D
K
F
----------
P
D
Y
L
-----------
T
V
S
P
P
I
G
D
L
Q
V
F
-
Y
K
E
S
K
K
R
F
D
-------
T
E
-------
E
E
F
K
K
R
A
Y
Q
C
V
V
L
L
Q
G
---
K
N
P
D
I
T
K
A
W
K
L
I
C
D
V
S
R
Q
E
L
N
K
-
I
Y
D
A
L
------
D
V
S
L
--
I
--
E
-
R
G
E
S
--
F
Y
--
Q
--
D
R
--
M
N
D
I
-
V
K
E
F
-
E
D
R
G
F
V
Q
V
-----
D
-----
D
-----
G
R
K
I
V
F
V
P
------
G
---
C
-
S
--
I
P
L
T
I
-
V
K
S
D
G
G
Y
T
Y
D
T
S
D
L
A
A
I
K
Q
--------
R
------------
L
F
E
E
----------------------------
K
----------------
A
-----------------
D
M
I
-----------
I
Y
V
V
D
N
G
Q
S
V
H
F
Q
T
I
F
A
A
A
Q
M
I
----
G
W
-
Y
-------------------
D
PKVT
R
-
V
F
H
A
G
F
G
-
V
V
-
L
G
-
E
D
K
--
K
--
K
F
K
T
R
S
G
E
T
V
--
R
L
M
D
L
L
G
E
G
L
K
R
S
M
D
K
L
----
K
---
E
K
-------------
E
R
-
D
K
--
V
L
T
A
E
E
L
N
A
A
Q
T
S
V
A
Y
G
C
I
K
Y
A
D
L
S
H
N
R
L
N
D
Y
I
F
S
F
D
K
M
L
D
D
R
-
G
N
T
A
A
--
Y
L
L
Y
A
F
T
R
I
R
S
I
A
R
L
A
-----
N
--
I
D
E
E
M
L
Q
K
A
----
A
----
R
----
E
----
T
--------
K
I
L
L
---
D
H
E
K
E
W
K
L
G
R
C
I
L
R
F
P
E
I
L
Q
K
I
L
-------
D
D
L
F
L
H
T
L
C
D
---
Y
I
Y
E
L
A
T
A
F
T
E
F
Y
-------
D
-
S
C
-------
Y
C
V
E
-
K
--------
D
-
R
--------
Q
T
-
G
K
ILKVN
M
W
R
M
L
L
C
E
A
V
A
A
V
M
A
K
G
F
D
I
L
G
I
K
P
V
Q
R
M
4
PsiBlast_PDB
89.69
33%
-82
- C2 -
4OBY
1
SYR_ECOLI
A:
[27-577]
-------------------------------------------------------------------------------------------
P
Q
V
---
R
Q
S
-
A
K
V
Q
F
G
D
Y
Q
-
A
N
G
M
M
----------
A
V
A
K
K
L
G
-----
M
A
-----
P
R
Q
L
A
E
Q
V
L
T
H
L
D
---
L
--
N
G
-
I
A
S
K
V
E
I
A
G
P
G
F
I
N
I
F
L
D
P
A
F
L
A
E
H
V
Q
Q
A
L
A
S
D
R
L
G
V
A
T
P
---
E
K
Q
T
I
V
V
D
Y
S
A
P
N
V
A
K
E
M
H
V
G
H
L
R
S
T
I
I
G
D
A
A
V
R
T
L
E
F
L
G
H
K
V
I
R
A
N
H
V
G
D
W
G
T
Q
F
G
M
L
I
A
W
L
E
K
Q
Q
-------------------------------
D
-
L
E
G
F
-
Y
R
D
A
K
K
H
Y
D
----------------
E
E
F
A
E
R
A
R
N
Y
V
V
K
L
Q
S
---
G
D
E
Y
F
R
E
M
W
R
K
L
V
D
I
T
M
T
Q
N
Q
I
-
T
Y
D
R
L
------
N
V
T
L
TR
D
--
D
V
M
G
E
S
--
L
Y
--
N
--
P
M
--
L
P
G
I
-
V
A
D
L
-
K
A
K
G
L
A
V
E
-----
S
-----
E
-----
G
A
T
V
V
F
L
D
E
F
KNKE
G
---
E
-
P
--
M
G
V
I
I
-
Q
K
K
D
G
G
Y
L
Y
T
T
T
D
I
A
C
A
K
Y
--------
R
------------
Y
E
T
L
----------------------------
H
----------------
A
-----------------
D
R
V
-----------
L
Y
Y
I
D
S
R
Q
H
Q
H
L
M
Q
A
W
A
I
V
R
K
A
G
-
Y
V
P
E
-
S
-------------------
V
----
P
-
L
E
H
H
M
F
G
M
M
L
-
G
--
K
D
G
--
K
--
P
F
K
T
R
A
G
G
T
V
--
K
L
A
D
L
L
D
E
A
L
E
R
A
R
R
L
V
----
A
---
E
K
N
P
---
D
----
M
P
A
D
E
L
E
K
--
L
A
N
A
---------
V
G
I
G
A
V
K
Y
A
D
L
S
K
N
R
T
T
D
Y
I
F
D
W
D
N
M
L
A
F
E
-
G
N
T
A
P
--
Y
M
Q
Y
A
Y
T
R
V
L
S
V
F
R
K
A
-----
E
--
I
D
------
E
----
E
----
Q
----
L
----
A
--------
A
A
P
V
I
I
R
E
D
R
E
A
Q
L
A
A
R
L
L
Q
-
F
E
E
T
L
T
V
V
A
-------
R
E
G
T
P
H
V
M
C
A
---
Y
L
Y
D
L
A
G
L
F
S
G
F
Y
-------
E
-
H
C
-------
P
I
L
S
A
E
--------
N
-
E
--------
E
V
R
N
S
-------
R
L
K
L
A
Q
L
T
A
K
T
L
K
L
G
L
D
T
L
G
I
E
T
V
E
R
-
22
HHSearch
88.64
30%
-80
- C2 -
2ZUE
2
SYR_PYRHO
A:
[3-629]
------------------------------------------------------------------
M
E
I
R
E
S
V
----------
K
E
R
I
E
E
I
I
K
E
I
---
A
P
Q
W
E
G
E
I
E
L
K
E
T
-
P
D
P
K
L
G
D
F
G
T
-
P
I
A
F
K
L
A
K
L
L
K
-----
R
P
-----
P
I
E
I
A
E
K
I
V
E
K
L
K
L
--
N
LP
E
G
-
I
-
K
D
V
K
A
V
N
G
-
Y
I
N
V
F
I
D
Y
P
H
F
A
R
I
L
I
N
D
I
L
A
K
G
D
R
F
G
S
S
E
I
G
K
G
K
K
V
I
V
E
H
T
S
V
N
P
T
K
P
L
H
M
G
H
A
R
N
A
I
L
G
D
V
M
A
R
I
L
R
F
L
G
Y
E
V
E
V
Q
N
Y
I
D
D
L
G
I
Q
F
A
Q
V
Y
W
G
Y
L
R
L
K
----------
E
E
F
E
R
I
M
N
E
L
R
E
R
GL
K
D
N
P
I
D
H
A
L
G
L
L
-
Y
V
E
V
N
R
R
L
E
-------
D
N
-------
P
E
L
E
N
E
I
R
D
I
M
K
K
L
E
S
---
G
E
L
----
Y
G
R
K
L
A
E
E
V
V
R
A
Q
M
V
-
T
T
Y
K
L
------
G
V
K
Y
--
D
--
L
L
V
W
E
S
--
D
I
--
V
R
R
K
L
--
F
E
I
A
-
L
E
L
L
-
S
K
N
E
N
F
Y
I
-----
P
SDGKY
R
-----
G
A
F
V
M
D
L
R
K
L
F---
P
---
D
-
M
KN
P
I
L
V
L
-
R
R
S
D
G
T
A
T
Y
T
G
K
D
I
A
Y
H
L
W
--------
K
------------
F
G
K
I
DVD
L
L
Y
K
E
WDST
T
W
T
T
A
PD
G
K
S
M
P
NKFG
N
----------------
A
-----------------
N
I
V
-----------
I
N
V
I
G
A
E
Q
K
H
P
Q
L
A
I
K
Y
A
L
Q
L
L
G
-
F
-
E
D
A
A
-------------------
A
----
N
-
L
Y
H
L
A
Y
E
-
H
V
-
E
--
R
P
E
--
G
--
K
F
S
G
R
K
G
T
W
V
GF
T
V
D
E
V
I
Q
E
A
V
K
R
A
R
E
L
I
----
E
---
E
K
N
P
AL-
S
----
D
-
E
E
K
-
A
E
--
V
A
E
K
---------
V
G
I
G
A
I
R
Y
N
L
I
K
Y
S
P
D
K
K
I
I
F
R
W
E
D
V
L
N
F
E
-
G
E
S
A
P
--
Y
I
Q
Y
A
H
A
R
C
S
S
I
L
R
K
A
-----
E
--
E
E
------
G
----
I
----
K
----
V
----
D
P
E
T
L
F
K
N
A
D
F
T
K
---
L
S
E
R
E
R
E
L
V
I
M
L
S
K
F
P
R
I
V
E
Q
A
G
-------
K
D
V
K
P
H
L
I
A
W
---
F
A
N
E
L
A
S
L
F
N
K
F
Y
-------
M
-
D
H
-------
P
V
L
K
-
A
--------
E
E
G
--------
V
R
-
E
A
-------
R
L
L
L
V
M
A
V
E
Q
V
L
K
N
A
L
Y
L
M
G
I
E
A
P
E
R
M
23
HHSearch
81.33
27%
-73
- C2 -
1IQ0
-
SYR_THET8
A:
[2-592]
--------------------------------------------------------------------
L
R
R
A
L
----------
E
E
A
I
A
Q
A
L
K
E
M
---
G
V
P
--
V
R
L
K
V
A
R
A
-
P
K
D
K
P
G
D
Y
G
V
-
P
-
L
F
A
L
A
K
E
L
R
-----
K
P
-----
P
Q
A
I
A
Q
E
L
K
D
R
L
P
L--
P
--
E
F
-
V
-
E
E
A
V
P
V
G
G
-
Y
L
N
F
R
L
R
T
E
A
L
L
R
E
A
L
R
----
P
K
A
P
F
P
----
R
R
P
G
V
V
L
V
E
H
T
S
V
N
P
N
K
E
L
H
V
G
H
L
R
N
I
A
L
G
D
A
I
A
R
I
L
A
Y
A
G
R
E
V
L
V
L
N
Y
I
D
D
T
G
R
Q
A
A
E
T
L
F
A
L
R
H
Y
G
----------
L
T
W
D
-----------
G
K
E
K
Y
D
H
F
A
G
R
A
-
Y
V
R
L
H
Q
D
P
E
-------
Y
--------
E
R
L
Q
P
A
I
E
E
V
L
H
A
L
E
R
---
G
E
L
-----
R
E
E
-
V
N
R
I
L
L
A
Q
M
A
-
T
M
H
A
L
------
N
A
R
Y
--
D
--
L
L
V
W
E
S
--
D
I
V
R
A
--
G
L
--
L
Q
K
A
-
L
A
L
L
-
E
Q
S
P
H
V
F
R
P
REGK
Y
-----
A
-----
G
A
L
V
M
D
A
S
P
V
----
I
PGL
E
-
D
--
P
F
F
V
L
-
L
R
S
N
G
T
A
T
Y
Y
A
K
D
I
A
F
Q
F
W
--------
K
------------
M
G
I
L
EG
L
R
F
R
P
YENPYYPG
L
R
T
S
A
PEGEAYTP
K
----------------
A
-----------------
E
E
T
-----------
I
N
V
V
D
V
R
Q
S
H
P
Q
A
L
V
R
A
A
L
A
L
A
G
-
Y
-
P
A
L
A
-------------------
E
----
K
-
A
H
H
L
A
Y
E
-
T
V
-
L
--
L
E
G
--
R
--
Q
M
S
G
----
A
V
--
S
V
D
E
V
L
E
E
A
T
R
R
A
R
A
I
V
----
E
---
E
K
N
P
---
D
----
H
-
P
D
K
-
E
E
--
A
A
R
M
---------
V
A
L
G
A
I
R
F
S
M
V
K
T
E
P
K
K
Q
I
D
F
R
Y
Q
E
A
L
S
F
E
-
G
D
T
G
P
--
Y
V
Q
Y
A
H
A
R
A
H
S
I
L
R
K
A
-----
G
--
E
W
------
G
----
A
----
P
---------
D
--------
L
-
S
Q
---
A
T
P
Y
E
R
A
L
A
L
D
L
L
D
F
E
E
A
V
L
E
A
A
-------
E
E
R
T
P
H
V
L
A
Q
---
Y
L
L
D
L
A
A
S
W
N
A
Y
Y
-------
N
-
A
R
ENGQPAT
P
V
L
T
-
A
--------
P
E
G
--------
L
R
-
E
L
-------
R
L
S
L
V
Q
S
L
Q
R
T
L
A
T
G
L
D
L
L
G
I
P
A
P
E
V
M
44
Fugue
79.99
26%
-70
- C2 -
1IQ0
-
SYR_THET8
A:
[1-592]
-------------------------------------------------------------------
M
L
R
R
A
L
----------
E
E
A
I
A
Q
A
L
K
E
M
---
G
V
P
-
V
R
L
K
V
-
A
R
A
-
P
K
D
K
P
G
D
Y
G
V
-
P
-
L
F
A
L
A
K
E
L
R
-----
K
P
-----
P
Q
A
I
A
Q
E
L
K
D
R
L
P
L--
P
--
E
F
-
V
-
E
E
A
V
P
V
G
G
-
Y
L
N
F
R
L
R
T
E
A
L
L
R
E
A
L
R
P
K
A
P
F
P
R
--------
R
P
G
V
V
L
V
E
H
T
S
V
N
P
N
K
E
L
H
V
G
H
L
R
N
I
A
L
G
D
A
I
A
R
I
L
A
Y
A
G
R
E
V
L
V
L
N
Y
I
D
D
T
G
R
Q
A
A
E
T
L
F
A
L
R
H
Y
G
----------
L
T
W
D
-----------
G
K
E
K
Y
D
H
F
A
G
R
A
-
Y
V
R
L
H
Q
D
P
E
-------
Y
--------
E
R
L
Q
P
A
I
E
E
V
L
H
A
L
E
R
---
G
E
L
------
R
E
E
V
N
R
I
L
L
A
Q
M
A
-
T
M
H
A
L
------
N
A
R
Y
--
D
--
L
L
V
W
E
S
--
D
I
--
V
--
R
A
G
L
L
Q
K
A
-
L
A
L
L
-
E
Q
S
P
H
V
F
R
P
REGK
Y
-----
A
-----
G
A
L
V
M
D
A
S
P
V
IPG-
L
---
E
-
D
--
P
F
F
V
L
-
L
R
S
N
G
T
A
T
Y
Y
A
K
D
I
A
F
Q
F
W
--------
K
M
GILEG
L
R
F
R
P
Y
E
N
P
Y
----------------------------
Y
PG
L
R
T
S
A
PEGEAYTPK
A
-----------------
E
E
T
-----------
I
N
V
V
D
V
R
Q
S
H
P
Q
A
L
V
R
A
A
L
A
L
A
G
-
Y
-
P
A
-
L
A
------------------
E
----
K
-
A
H
H
L
A
Y
E
-
T
V
-
L
--
L
E
G
--
R
--
Q
----
M
S
G
A
V
--
S
V
D
E
V
L
E
E
A
T
R
R
A
R
A
I
V
----
E
---
E
K
N
P
---
D
----
H
-
P
D
K
-
E
E
--
A
A
R
M
---------
V
A
L
G
A
I
R
F
S
M
V
K
T
E
P
K
K
Q
I
D
F
R
Y
Q
E
A
L
S
F
E
-
G
D
T
G
P
--
Y
V
Q
Y
A
H
A
R
A
H
S
I
L
R
K
A
-----
G
----------
E
----
W
----
G
----
A
----
P
--------
D
L
S
Q
---
A
T
P
Y
E
R
A
L
A
L
D
L
L
D
F
E
E
A
V
L
E
A
A
-------
E
E
R
T
P
H
V
L
A
Q
---
Y
L
L
D
L
A
A
S
W
N
A
Y
Y
-------
N
-
A
R
-------
E
N
G
Q
-
P
--------
A
-
T
PVLTAPE
G
L
R
-
E
L
-------
R
L
S
L
V
Q
S
L
Q
R
T
L
A
T
G
L
D
L
L
G
I
P
A
P
E
V
M
10
PsiBlast_PDB
78.71
26%
-72
- C2 -
1IQ0
-
SYR_THET8
A:
[10-592]
--------------------------------------------------------------------------------------
I
A
Q
A
L
K
E
M
---
G
V
P
-
V
R
L
K
V
A
R
A
P
-
K
D
K
P
-
G
D
Y
G
V
-
P
-
L
F
A
L
A
K
E
L
R
-----
K
P
-----
P
Q
A
I
A
Q
E
L
K
D
R
L
P
---
L
--
P
E
-
F
V
E
E
A
V
P
V
G
G
-
Y
L
N
F
R
L
R
T
E
A
L
----
L
R
E
A
L
R
P
K
A
P
F
P
R
R
P
----
G
V
V
L
V
E
H
T
S
V
N
P
N
K
E
L
H
V
G
H
L
R
N
I
A
L
G
D
A
I
A
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I
L
A
Y
A
G
R
E
V
L
V
L
N
Y
I
D
D
T
G
R
Q
A
A
E
T
L
F
A
L
R
H
Y
G
LTWDGKEK
Y
-
D
H
F
A
-----------
G
R
A
----------
Y
V
R
L
H
Q
D
P
E
-------
Y
E
RL
Q
----
P
A
I
E
----
E
V
L
H
A
L
E
----------------
R
G
E
L
R
E
E
V
N
R
I
L
L
A
Q
M
A
T
M
H
A
L
N
A
R
Y
--
D
L
L
V
W
E
S
D
I
--
V
R
--
A
--
G
L
--
L
Q
K
A
-
L
A
L
L
-
E
Q
S
P
H
V
F
R
-----
P
-----
R
EGKYA
G
A
L
V
M
D
A
S
P
V
IP--
G
---
L
-
E
--
D
P
F
F
V
L
L
R
S
N
G
T
A
T
Y
Y
A
K
D
I
A
F
Q
F
W
K
M
GILEG
L
R
------------
F
R
P
Y
----------------------------
E
NP--------------
Y
-----------------
Y
P
G
-----------
L
R
T
S
A
P
E
G
E
A
Y
T
P
K
A
E
E
T
I
N
V
V
D
-
V
-
R
Q
-
S
HPQ
A
L
V
R
A
A
L
A
L
A
GY
P
A
L
A
E
----
K
-
A
H
H
L
A
Y
E
-
T
V
-
L
--
L
E
G
--
R
--
Q
M
S
G
----
A
V
--
S
V
D
E
V
L
E
E
A
T
R
R
A
R
A
I
V
----
E
---
E
K
N
P
---
D
----
H
-
P
D
K
-
E
E
--
A
A
R
M
---------
V
A
L
G
A
I
R
F
S
M
V
K
T
E
P
K
K
Q
I
D
F
R
Y
Q
E
A
L
S
F
E
-
G
D
T
G
P
--
Y
V
Q
Y
A
H
A
R
A
H
S
I
L
R
K
A
-----
G
EW
G
A
------
P
----
D
----
L
----
S
----
Q
--------
A
T
P
Y
---
E
R
A
L
A
L
D
L
L
----
D
F
E
E
A
V
L
E
A
A
-------
E
E
R
T
P
H
V
L
A
Q
---
Y
L
L
D
L
A
A
S
W
N
A
Y
Y
N
ARENGQ
P
-
A
T
-------
P
V
L
T
-
A
--------
P
-
E
--------
G
L
-
R
E
L
------
R
L
S
L
V
Q
S
L
Q
R
T
L
A
T
G
L
D
L
L
G
I
P
A
P
E
V
M
45
Fugue
71.82
40%
-88
- C2 -
1BS2
1
SYRC_YEAST
A:
[136-483]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
C
K
L
V
E
N
K
K
V
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
G
K
Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
K
D
I
E
E
E
GDSIP
L
E
-------
Q
S
T
N
G
K
A
R
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
K
I
W
K
R
F
R
E
F
S
I
E
K
Y
I
D
-
T
Y
A
R
L
------
N
I
K
Y
--
D
--
V
Y
S
G
E
S
Q-
V
S
--
K
--
E
S
--
M
L
K
A
-
I
D
L
F
-
K
E
K
G
L
T
H
E
-----
D
-----
K
-----
G
A
V
L
I
D
L
T
K
F
----
N
---
K
-
K
L-
G
K
A
I
V
-
Q
K
S
D
G
T
T
L
Y
L
T
R
D
V
G
A
A
M
D
--------
R
------------
Y
E
K
Y
----------------------------
H
----------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
S
Q
Q
D
L
H
A
A
Q
F
F
E
I
L
K
Q
M
G
-
F
-
E
W
-
A
-------------------
K
----
D
-
L
Q
H
V
N
F
G
-
M
V
-
Q
--
G
--------
M
S
T
R
K
G
T
V
V
--
F
L
D
N
I
L
E
E
T
K
E
K
M
H
E
V
M
----
K
---
K
N
E
N
KYA
Q
----
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
I
S
A
V
M
I
Q
D
M
Q
G
K
R
I
N
N
Y
E
F
K
W
E
R
M
L
S
F
E
-
G
D
T
G
P
--
Y
L
Q
Y
A
H
S
R
L
R
S
V
E
R
N
A
-----
S
--
G
I
------
T
----
Q
----
E
----
K
----
W
--------
I
N
A
D
---
F
S
L
L
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
-------
R
N
A
I
K
T
H
E
P
T
---
T
V
V
T
Y
L
F
K
L
T
H
Q
V
-------
S
-
S
C
-------
Y
D
V
L
-
W
--------
V
-
A
--------
G
Q
-
T
E
-------
E
L
A
T
A
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
47
Fugue
71.51
40%
-85
- C2 -
1F7U
1
SYRC_YEAST
A:
[136-483]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
C
K
L
V
E
N
K
K
V
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
G
K
Q
F
G
L
L
A
V
G
F
E
R
Y
G
----------
N
E
E
A
-----------
L
V
K
D
P
I
H
H
L
F
D
V
-
Y
V
R
I
N
K
D
I
E
E
E
GDSIP
L
E
-------
Q
S
T
N
G
K
A
R
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
K
I
W
K
R
F
R
E
F
S
I
E
K
Y
I
D
-
T
Y
A
R
L
------
N
I
K
Y
--
D
--
V
Y
S
G
E
S
QV
S
K
-----
E
S
--
M
L
K
A
-
I
D
L
F
-
K
E
K
G
L
T
H
E
-----
D
K----------
G
A
V
L
I
D
L
T
K
F
----
N
---
K
K
L
--
G
K
A
I
V
-
Q
K
S
D
G
T
T
L
Y
L
T
R
D
V
G
A
A
M
D
--------
R
------------
Y
E
K
Y
-----------------------------H---------------
F
-----------------
D
K
M
-----------
I
Y
V
I
A
S
Q
Q
D
L
H
A
A
Q
F
F
E
I
L
K
Q
M
G
F--
E
W
-
A
-------------------
K
----
D
-
L
Q
H
V
N
F
G
-
M
V
-
Q
----------
G
M
S
T
R
K
G
T
V
V
--
F
L
D
N
I
L
E
E
T
K
E
K
M
H
E
V
M
----
K
---
K
N
E
N
---
K
Y
A
Q
-
I
-
E
H
P
-
E
E
--
V
A
D
L
---------
V
G
I
S
A
V
M
I
Q
D
M
Q
G
K
R
I
N
N
Y
E
F
K
W
E
R
M
L
S
F
E
-
G
D
T
G
P
--
Y
L
Q
Y
A
H
S
R
L
R
S
V
E
R
N
A
-----
S
--
G
I
------
T
----
Q
----
E
----
K
----
W
--------
I
N
A
D
---
F
S
L
L
K
E
P
A
A
K
L
L
I
R
L
L
G
Q
Y
P
D
V
L
-------
R
N
A
I
K
T
H
E
P
T
---
T
V
V
T
Y
L
F
K
L
T
H
Q
V
-------
S
-
S
C
-------
Y
D
V
L
-
W
--------
V
-
A
--------
G
Q
-
T
E
-------
E
L
A
T
A
R
L
A
L
Y
G
A
A
R
Q
V
L
Y
N
G
M
R
L
L
G
L
T
24
HHSearch
71.47
22%
-77
* C2 *
3FNR
5
SYR_CAMJE
A:
[3-454]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
K
T
F
L
N
E
L
A
-
N
Q
A
L
T
N
P
N
D
F
T
K
G
-
E
K
K
Q
E
S
F
L
L
E
Y
V
S
A
N
P
T
G
P
L
H
I
G
H
A
R
G
A
V
F
G
D
T
L
T
R
L
A
R
H
L
G
Y
K
F
N
T
E
Y
Y
V
N
D
A
G
N
Q
I
Y
L
L
G
L
S
I
L
L
S
V
----------
K
E
S
I
-----------
L
-
H
E
N
V
E
Y
P
E
Q
Y
-
Y
K
---------------
G
-------
E
Y
I
V
D
L
A
K
E
A
F
E
K
F
G
K
EFF
S
E
E
N
I
P
S
L
A
D
W
A
K
D
K
M
L
V
L
I
K
Q
-
N
L
E
Q
A
------
K
I
K
I
--
D
--
S
Y
V
S
E
R
--
S
Y
--
Y
--
D
A
--
L
N
A
T
-
L
E
S
L
-
K
E
H
K
G
I
Y
E
-----
Q
-----
E
-----
G
K
I
W
L
A
S
S
Q
K
----
G
---
D
-
E
--
K
D
R
V
I
-
I
R
E
D
G
R
G
T
Y
L
A
A
D
I
V
Y
H
K
D
--------
K
------------
M
S
R
-----------------------------
G
----------------
Y
-----------------
G
K
C
-----------
I
N
I
W
G
A
D
H
H
G
Y
I
P
R
M
K
A
A
M
E
F
L
G
-
F
-
D
S
-
N
------------------------
N
-
L
E
I
I
L
A
Q
-
M
V
S
L
L
-
K
D
G
EP
Y
--
K
M
---
A
G
N
F
I
--
L
M
S
D
V
V
D
-------------------------------------------
E
---------
I
G
S
D
A
L
R
Y
I
F
L
S
K
K
C
D
T
H
L
E
F
D
I
S
D
L
Q
K
E
D
S
S
N
P
V
Y
--
Y
I
N
Y
A
H
A
R
I
H
Q
V
F
A
K
A
-----
G
--
K
K
------
I
----
D
----
D
----
V
MK--
A
--------
D
L
Q
S
---
L
N
Q
D
G
V
N
L
L
F
E
A
L
N
L
K
A
V
L
N
D
A
F
-------
E
A
R
A
L
Q
K
I
P
D
---
Y
L
K
N
L
A
A
N
F
H
K
F
Y
-------
N
-
E
N
-------
K
V
V
G
-
S
--------
A
----------
N
E
-
N
D
-------
L
L
K
L
F
S
L
V
A
L
S
I
K
T
A
F
S
L
M
G
I
E
A
K
N
K
M
11
PsiBlast_PDB
66.86
24%
-73
- C2 -
3FNR
5
SYR_CAMJE
A:
[34-454]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Y
V
S
A
N
P
T
G
P
L
H
I
G
H
A
R
G
A
V
F
G
D
T
L
T
R
L
A
R
H
L
G
Y
K
F
N
T
E
Y
Y
V
N
D
A
G
N
Q
I
Y
L
L
G
L
S
I
L
L
S
V
----------
K
E
S
I
-----------
L
--
H
E
N
V
E
Y
P
E
Q
-
Y
Y
K
----
G
E
-------
Y
I
-------
V
D
L
A
K
E
A
F
E
K
F
G
K
E
F
F
---
S
E
E
N
I
P
S
L
A
D
W
A
K
D
K
M
L
V
L
I
K
Q
-
N
L
E
Q
A
------
K
I
K
I
--
D
--
S
Y
V
S
E
R
--
S
Y
--
Y
--
D
A
--
L
N
A
T
-
L
E
S
L
-
K
E
H
K
G
I
Y
E
-----
Q
-----
E
-----
G
K
I
W
L
A
S
S
Q
K
----
G
---
D
-
E
--
K
D
R
V
I
-
I
R
E
D
G
R
G
T
Y
L
A
A
D
I
---
V
Y
--------
H
K
D
----------
K
M
S
R
----------------------------
G
----------------
Y
-----------------
G
K
C
-----------
I
N
I
W
G
A
D
H
H
G
Y
I
P
R
M
K
A
A
M
E
F
L
G
-
F
-
D
--
S
-------------------
N
----
N
-
L
E
I
I
L
A
Q
-
M
V
-
S
L
L
K
D
G
--
E
PY
K
M
---
A
G
N
F
I
--
L
M
S
D
V
V
D
E
----------------------------------------------------
I
G
S
D
A
L
R
Y
I
F
L
S
K
K
C
D
T
H
L
E
F
D
I
S
D
L
Q
K
-
E
-
D
S
S
N
P
V
Y
Y
I
N
Y
A
H
A
R
I
H
Q
V
F
A
K
A
---------------------------------------------
G
K
K
I
---
D
D
V
M
K
A
D
L
Q
S
L
N
Q
D
G
V
N
L
L
F
E
A
L
N
L
K
A
V
L
N
D
A
F
E
A
R
A
L
Q
K
I
P
D
Y
L
K
N
L
A
A
N
F
H
K
F
Y
-------
N
-
E
N
-------
K
V
V
G
-
S
--------
A
-
N
--------
E
--
N
D
-------
L
L
K
L
F
S
L
V
A
L
S
I
K
T
A
F
S
L
M
G
I
E
A
K
N
K
M