@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2061: (2015-12-13 )
MKLQKPKGTQDILPGESAKWQYVENVIRNLFKQYHYDEIRTPMFEHYEVISRSVGDTTDIVTKEMYDFHDKGDRHITLRPEGTAPVVRSYVENKLFAPEVQKPTKMYYIGSMFRYERPQAGRLREFHQVGVECFGSNNPATDVETIAMGHHLFEDLGIKNVKLHLNSLGNPESRQAYRQALIDYLTPIREQLSKDSQRRLNENPLRVLDSKEPEDKLAVENAPSILDYLDESSQAHFDAVCHMLDALNIPYIIDTNMVRGLDYYNHTIFEFITEIEDNELTICAGGRYDGLVSYFGGPETPAFGFGLGLERLLLILDKQGISLPIENTIDLYIAVLGSEANLAALDLAQSIRHQGFKVERDYLGRKIKAQFKSADTFNAKVIMTLGSSEVDSKEVGLKNNQTRQEVKVSFENIKTDFSSVLKQLGL
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70-........80........90...-.....100.......110.......120.......130.......140.......150......-.-160.......170.......180.......190.......200.......210.......220..--.......230.......240.......250.......260.......270....---...---280.......290.......300.......310.......320.......330.......340.......350..--....----.360.......370.......380.......390.......400.......410.......420....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKLQKPKGTQDILPGES
A
K
W
Q
Y
V
E
N
V
I
R
N
L
F
K
Q
Y
H
Y
D
E
IR
T
P
M
F
E
H
Y
E
V
I
S
R
SVGD
T
T
D
I
V
T
K
E
M
Y
DFHDK-GD
R
H
I
T
LRPEG
T
A
P
V
V
R
S
Y
V
ENK-LFAPEVQK
P
T
K
M
Y
Y
I
G
S
M
FRYERPQAG
R
L
R
E
F
H
Q
V
G
V
E
C
FGSNNPAT
D
V
E
T
I
A
M
G
H
H
L
F
E
D
LGI-
K
-
N
V
K
L
H
LNSLG
N
P
E
S
R
Q
A
Y
R
Q
A
L
I
D
Y
L
T
P
I
R
E
Q
L
S
K
D
S
Q
R
RLNENP
L
R
VLDSKEPEDKLAVE--N
A
--
P
S
I
L
D
Y
LDESSQ
A
H
F
D
A
V
C
H
M
L
D
ALNI
P
Y
I
IDT
N
M
VR
G
L
D
Y
Y
N
H
T
I
F
E
F
I
T
EIE---DN
E
---
L
T
I
C
AGGRYD
G
L
V
S
YFGGPETPA
F
G
F
G
L
G
L
E
R
L
L
L
I
L
DKQGISLPIENT
I
D
L
Y
I
A
V
LGSEA
N
L
A
A
L
D
L
A
Q
S
I
R
HQ--G
F
K
V
----
E
R
D
YLG
R
K
I
K
A
Q
FKSADTFN
A
K
V
I
M
T
LGSSEVD
S
K
EVGLKNNQ
T
R
Q
E
V
K
V
S
F
E
N
I
K
T
D
F
S
S
V
L
K
QLGL
41
HHSearch
92.87
47%
-107
- C1 -
1QE0
-
SYH_STAAU
A:
[1-419]
-
M
I
K
I
P
R
G
T
Q
D
I
L
P
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
S
T
D
L
F
A
R
-----------
E
M
Y
T
F
K
D
K
-
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
S
Y
I
E
H
K
M
Q
G
N
P
N
--
Q
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
-------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
E
N
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
-
K
-
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
L
H
T
D
P
M
R
I
L
--------------
T
A
--
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
D
L
G
I
P
Y
T
E
D
P
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
P
NYD
G
A
I
---
T
T
L
C
G
G
G
R
Y
N
G
L
L
E
L
L
D
G
P
S
E
T
G
I
G
F
A
L
S
I
E
R
L
L
L
A
L
E
E
E
G
I
E
L
D
I
E
E
N
L
D
L
F
I
V
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
I
K
A
----
D
K
D
Y
L
Q
R
K
I
K
G
Q
M
K
Q
A
D
R
L
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
N
K
I
D
V
K
N
M
T
T
G
E
S
E
T
I
E
L
D
A
L
V
E
Y
F
K
K
-------
33
PsiBlast_CBE
91.75
42%
-111
- C1 -
4E51
1
SYH_BURTA
B:
[31-428]
-
K
L
T
G
V
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
------
D
I
V
E
K
E
M
Y
S
F
V
D
A
L
N
G
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
-
M
L
---
Y
D
G
P
K
R
L
W
Y
I
G
P
M
F
R
H
E
R
-----
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
-
T
-
G
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
------
Q
R
R
L
Y
T
N
P
L
R
V
L
----
P
A
L
Q
E
I
V
R
--
N
A
--
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
-----------
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
L
-
V
P
E
Q
E
G
V
D
V
Y
V
V
H
Q
G
D
A
A
R
E
Q
A
F
I
V
A
E
R
L
R
D
T
--
G
L
D
V
I
L
HC
S
A
D
G
A
G
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
S
V
Q
Q
S
V
P
V
E
S
L
T
E
F
L
I
N
A
M
V
A
-----
1
PsiBlast_PDB
89.95
48%
-110
- C1 -
1QE0
-
SYH_STAAU
A:
[5-403]
-----
P
R
G
T
Q
D
I
L
P
E
D
S
K
K
W
R
Y
I
E
N
Q
L
D
E
L
M
T
F
Y
N
Y
K
E
I
R
T
P
I
F
E
S
T
D
L
F
A
R
-----------
E
M
Y
T
F
K
D
K
-
G
D
R
S
I
T
L
R
P
E
G
T
A
A
V
V
R
S
Y
I
E
H
K
-
M
Q
G
N
P
N
Q
-
P
I
K
L
Y
Y
N
G
P
M
F
R
Y
-------
Y
R
Q
F
N
Q
F
G
V
E
A
I
G
A
E
N
P
S
V
D
A
E
V
L
A
M
V
M
H
I
Y
Q
S
F
G
L
-
K
-
H
L
K
L
V
I
N
S
V
G
D
M
A
S
R
K
E
Y
N
E
A
L
V
K
H
F
E
P
V
I
H
E
F
C
S
D
C
Q
S
R
L
H
T
D
P
M
R
I
L
--------------
T
A
--
P
R
I
T
D
F
L
N
E
E
S
K
A
Y
Y
E
Q
V
K
A
Y
L
D
D
L
G
I
P
Y
T
E
D
P
N
L
V
R
G
L
D
Y
Y
T
H
T
A
F
E
L
M
M
D
N
P
---
N
Y
D
GAI
T
T
L
C
G
G
G
R
Y
N
G
L
L
E
L
L
D
G
P
S
E
T
G
I
G
F
A
L
S
I
E
R
L
L
L
A
L
E
E
E
G
I
E
L
D
I
E
E
N
L
D
L
F
I
V
T
M
G
D
Q
A
D
R
Y
A
V
K
L
L
N
H
L
R
H
N
--
G
I
K
A
----
D
K
D
Y
L
Q
R
K
I
K
G
Q
M
K
Q
A
D
R
L
G
A
K
F
T
I
V
I
G
D
Q
E
L
E
N
N
K
I
D
V
K
N
M
T
T
G
E
S
E
T
I
E
L
D
A
L
V
E
Y
F
K
K
-------
6
PsiBlast_PDB
89.69
42%
-98
- C1 -
4E51
1
SYH_BURTA
A:
[31-428]
-
K
L
T
G
V
K
G
M
N
D
I
L
P
Q
D
A
G
L
W
E
F
F
E
A
T
V
K
S
L
L
R
A
Y
G
Y
Q
N
I
R
T
P
I
V
E
H
T
P
L
F
T
R
G
I
G
E
V
T
D
I
V
E
K
E
M
Y
S
F
V
D
A
L
N
G
E
N
L
T
L
R
P
E
N
T
A
A
V
V
R
A
A
I
E
H
N
-
M
L
---
Y
D
G
P
K
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
---
R
Y
R
Q
F
H
Q
V
G
V
E
A
L
G
F
A
G
P
D
A
D
A
E
I
V
M
M
C
Q
R
L
W
E
D
L
G
L
-
T
-
G
I
K
L
E
I
N
S
L
G
L
A
E
E
R
A
A
H
R
V
E
L
I
K
Y
L
E
Q
H
A
D
K
L
D
D
D
A
Q
R
R
L
Y
T
N
P
L
R
V
L
D
T
K
N
P
A
L
Q
E
I
V
R
--
N
A
--
P
K
L
I
D
F
L
G
D
V
S
R
A
H
F
E
G
L
Q
R
L
L
K
A
N
N
V
P
F
T
I
N
P
R
L
V
R
G
L
D
Y
Y
N
L
T
V
F
E
W
V
T
D
K
----------
G
T
V
A
A
G
G
R
Y
D
P
L
I
E
Q
L
G
G
K
P
T
A
A
C
G
W
A
M
G
I
E
R
I
L
E
L
L
K
E
E
H
L
-
V
P
E
Q
E
G
V
D
V
Y
V
V
H
Q
G
D
A
A
R
E
Q
A
F
I
V
A
E
R
L
R
D
T
--
G
L
D
V
I
L
HC
S
A
D
G
A
G
A
S
F
K
S
Q
M
K
R
A
D
A
S
G
A
A
F
A
V
I
F
G
E
D
E
V
T
N
G
T
A
S
V
K
P
L
S
V
Q
Q
S
V
P
V
E
S
L
T
E
F
L
I
N
A
M
V
A
-----
42
HHSearch
89.55
39%
-93
- C1 -
1H4V
1
SYH_THET2
B:
[2-420]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
------
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
W
P
--
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
----
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
--
E
L
GV
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
------------
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
37
PsiBlast_CBE
89.12
38%
-94
- C1 -
1ADJ
2
SYH_THET8
D:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
7
PsiBlast_PDB
88.92
38%
-91
- C1 -
1ADJ
2
SYH_THET8
A:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
29
PsiBlast_CBE
88.89
41%
-101
- C1 -
1HTT
2
SYH_ECOLI
B:
[4-422]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
----------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
40
HHSearch
88.86
42%
-95
- C1 -
1HTT
2
SYH_ECOLI
A:
[3-422]
-
N
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
-
Y
N
--
Q
E
Q
R
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
-
S
E
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
-------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
38
PsiBlast_CBE
88.79
38%
-94
- C1 -
1ADJ
2
SYH_THET8
C:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
35
PsiBlast_CBE
88.75
38%
-90
- C1 -
1ADY
2
SYH_THET8
C:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
2
PsiBlast_PDB
88.53
41%
-96
- C1 -
1KMM
1
SYH_ECOLI
A:
[5-423]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
L
V
A
F
L
E
Q
H
---------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
34
PsiBlast_CBE
88.48
38%
-88
- C1 -
1ADY
2
SYH_THET8
D:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
24
PsiBlast_CBE
88.41
41%
-97
- C1 -
1KMM
1
SYH_ECOLI
D:
[5-423]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
---------------------------------------------------------------
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
39
PsiBlast_CBE
88.27
38%
-93
- C1 -
1ADJ
2
SYH_THET8
B:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
27
PsiBlast_CBE
88.03
41%
-98
- C1 -
1HTT
2
SYH_ECOLI
D:
[4-422]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
----------------------------------------------------------------
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
9
PsiBlast_PDB
88.02
38%
-96
- C1 -
1H4V
1
SYH_THET2
B:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
------
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
----
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
------------
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
32
PsiBlast_CBE
87.98
41%
-94
- C1 -
2EL9
1
SYH_ECOLI
B:
[12-430]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
-------------------------------------------------
A
L
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
S
L
---
G
S
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
31
PsiBlast_CBE
87.76
41%
-95
- C1 -
2EL9
1
SYH_ECOLI
C:
[12-430]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
Y
R
D
A
-------------------------------------------------
G
D
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-----------
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
36
PsiBlast_CBE
87.60
38%
-87
- C1 -
1ADY
2
SYH_THET8
B:
[2-412]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
G
V
G
A
A
T
D
I
V
R
K
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
E
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
EL
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----
4
PsiBlast_PDB
87.48
41%
-95
- C1 -
1HTT
2
SYH_ECOLI
A:
[4-422]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
-------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
L
P
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
28
PsiBlast_CBE
87.27
41%
-97
- C1 -
1HTT
2
SYH_ECOLI
C:
[4-422]
--
I
Q
A
I
R
G
M
N
D
Y
L
P
G
E
T
A
I
W
Q
R
I
E
G
T
L
K
N
V
L
G
S
Y
G
Y
S
E
I
R
L
P
I
V
E
Q
T
P
L
F
K
R
A
I
G
E
V
T
D
V
V
E
K
E
M
Y
T
F
E
D
R
-
N
G
D
S
L
T
L
R
P
E
G
T
A
G
C
V
R
A
G
I
E
H
G
-
L
L
Y
N
Q
E
Q
R
---
L
W
Y
I
G
P
M
F
R
H
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
L
G
C
E
V
F
G
L
Q
G
P
D
I
D
A
E
L
I
M
L
T
A
R
W
W
R
A
L
G
I
S
E
-
H
V
T
L
E
L
N
S
I
G
S
L
E
A
R
A
N
-------------------------------------------------------
Y
L
D
E
E
S
R
E
H
F
A
G
L
C
K
L
L
E
S
A
G
I
A
Y
T
V
N
Q
R
L
V
R
G
L
D
Y
Y
N
R
T
V
F
E
W
V
T
N
-------
Q
---
G
T
V
C
A
G
G
R
Y
D
G
L
V
E
Q
L
G
G
R
A
T
P
A
V
G
F
A
M
G
L
E
R
L
V
L
L
V
Q
A
V
N
P
E
F
K
A
D
P
V
V
D
I
Y
L
V
A
S
G
A
D
T
Q
S
A
A
M
A
L
A
E
R
L
R
D
E
LP
G
V
K
L
----
M
T
N
H
G
G
G
N
F
K
K
Q
F
A
R
A
D
K
W
G
A
R
V
A
V
V
L
G
E
S
E
V
A
N
G
T
A
V
V
K
D
L
R
S
G
E
Q
T
A
V
A
Q
D
S
V
A
A
H
L
R
T
L
L
G
----
10
PsiBlast_PDB
86.53
38%
-92
- C1 -
4RDX
2
SYH_THET2
A:
[4-414]
-
T
A
R
A
V
R
G
T
K
D
L
F
G
K
E
L
R
M
H
Q
R
I
V
A
T
A
R
K
V
L
E
A
A
G
A
L
E
L
V
T
P
I
F
E
E
T
Q
V
F
E
K
-----------
E
M
F
T
F
Q
D
R
-
G
G
R
S
L
T
L
R
P
E
G
T
A
A
M
V
R
A
Y
L
E
H
G
-
M
K
V
--
W
P
Q
P
V
R
L
W
M
A
G
P
M
F
R
A
E
R
P
Q
K
G
R
Y
R
Q
F
H
Q
V
N
Y
E
A
L
G
S
E
N
P
I
L
D
A
E
A
V
V
L
L
Y
E
C
L
K
E
L
G
L
-
R
-
R
L
K
V
K
L
S
S
V
G
D
P
E
D
R
A
R
Y
N
A
Y
L
R
E
V
L
S
P
H
R
E
A
L
S
E
D
S
K
E
R
L
E
L
N
P
M
R
I
L
D
S
K
S
E
R
D
Q
A
L
L
K
E
L
G
V
--
R
P
M
L
D
F
L
G
E
E
A
R
A
H
L
K
E
V
E
R
H
L
E
R
L
S
V
P
Y
E
L
E
P
A
L
V
R
G
L
D
Y
Y
V
R
T
A
F
E
V
H
H
E
E
I
---
G
A
Q
---
S
A
L
G
G
G
G
R
Y
D
G
L
S
E
L
L
G
G
P
R
V
P
G
V
G
F
A
F
G
V
E
R
V
A
L
A
L
E
A
E
G
F
G
L
P
E
E
K
G
P
D
L
Y
L
I
P
L
T
E
E
A
V
A
E
A
F
Y
L
A
E
A
L
R
P
R
---
L
R
A
----
E
Y
A
L
A
P
R
K
P
A
K
G
L
E
E
A
L
K
R
G
A
A
F
A
G
F
L
G
E
D
E
L
R
A
G
E
V
T
L
K
R
L
A
T
G
E
Q
V
R
L
S
R
E
E
V
P
G
Y
L
L
Q
A
L
G
----