@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2089: (2015-12-13 )
MTTLITTFQERFGDWTQSLIEHLQLSLLTLILATLIAIPLGIIISHYKKISHVVLQITGIFQTIPSLALLGLFIPFMGIGTVPAVVALIIYALFPILQNTVTVLMQIDANLIEAATAFGMTRWERLKKFELALSMPVIISGIRTASVMIIGTATLASLIGAGGLGSFILLGIDRNNPSLILIGAISSAVLAIIFSGLIGLLEKARLRTIAVSGILLLAGLGLSYAPKWMPGTNTATITVAGKLGTEPDILINMYKELIEDQTDIKVKLKPNFGKTTFLYQALKSGDIDLYPEFTGTITSSLLKNPPKVSNNPKQVYNLAKNGILKQDKLSLLSPMAYQNTYAVAVKKDYAEANQLKNISDLKKLDKLKAGFTLEFKDREDGSIGLQKHYGLNLDISTLEPALRYQAINSKDVNIIDAYSTDSELIQYQLQILKDDKHLFPPYQGAPLLRQDTIKKYPQVKKALNKLAGHITEKEMQEMNYQVAVKHKSAATVAKQYLKAHHIIK
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230...-....240.......250.......260--.....--..270.......280.......290-.-....-...300.......310.......320.......330.......340.......350.......360.-.-..-...370..------..-...-.-380.......390------...-.-..-...400-.........410.......420.......430.......440.......450.......460.......470.......480.......490.......500..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
T
L
I
T
T
F
Q
E
R
F
G
D
W
T
Q
S
L
I
E
H
L
Q
L
S
L
L
T
L
I
L
A
T
L
I
A
I
P
L
G
I
I
I
S
H
Y
K
K
I
S
H
V
V
L
Q
I
T
G
I
F
Q
T
I
P
S
L
A
L
L
G
L
F
I
P
F
MGI
G
T
V
P
A
V
V
A
L
I
I
Y
A
L
F
P
I
L
Q
N
T
V
T
V
L
M
QI
D
A
N
L
I
E
A
A
T
A
F
G
M
T
R
W
E
R
L
K
K
F
E
L
A
LS
M
P
V
I
I
SGI
R
T
A
S
V
M
I
I
G
T
A
T
L
A
S
L
I
GAGGL
G
S
F
I
L
L
G
IDRNNP
S
L
I
L
I
G
A
I
S
S
A
V
L
A
I
I
F
S
G
L
I
G
L
L
E
K
AR
L
R
T
I
A
V
S
G
I
L
L
L
A
GLGLSYAPKWMPGT
N
T
A
-
T
I
T
V
AGKLGTE
P
D
I
L
I
N
M
Y
K
E
L
IEDQT--
D
I
K
V
K
--
L
KPNFG
K
T
T
F
L
Y
Q
A
L
KSGD
I
D
LY-P-
E
-
F
T
G
T
-
I
T
S
S
L
LKNPPKVSN
N
P
K
Q
V
Y
N
L
A
KNGIL
K
Q
D
K
L
S
L
LSPMAYQ
N
T
Y
A
V
A
V
K
K
D
Y
A
E
A
N
QLK
N
I
S
D
L
K
K
-
L
-
D
K
-LKAG
F
-
T
L
------
E
F
-KDR-E-DGSIGLQKHYG--------L
N
L
-
D
-
I
S
-TLE
P
---
A
L
R
Y
QAINSKD
V
N
I
I
D
AYST
D
S
E
L
I
Q
Y
Q
L
Q
I
LKDDKHLFPPYQGAPL
L
R
Q
D
T
I
K
K
Y
P
Q
V
K
K
A
L
N
K
L
A
G
HI
T
E
K
E
M
Q
EM
N
Y
Q
V
A
V
KH
K
S
A
A
T
V
A
K
Q
Y
L
K
A
HHIIK
1
PsiBlast_PDB
89.95
34%
-43
- C2 -
3PPN
-
OPUCC_BACSU
A:
[32-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
--
24
PsiBlast_CBE
87.98
34%
-46
- C2 -
3PPO
1
OPUCC_BACSU
B:
[40-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
21
PsiBlast_CBE
87.80
34%
-46
- C2 -
3PPR
1
OPUCC_BACSU
B:
[41-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
23
PsiBlast_CBE
87.21
34%
-47
- C2 -
3PPP
1
OPUCC_BACSU
B:
[40-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
5
PsiBlast_PDB
87.08
34%
-45
- C2 -
3PPR
1
OPUCC_BACSU
A:
[41-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
2
PsiBlast_PDB
86.82
34%
-45
- C2 -
3PPO
1
OPUCC_BACSU
A:
[40-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
4
PsiBlast_PDB
86.51
34%
-46
- C2 -
3PPQ
1
OPUCC_BACSU
A:
[41-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
3
PsiBlast_PDB
85.84
34%
-45
- C2 -
3PPP
1
OPUCC_BACSU
A:
[40-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
12
PsiBlast_PDB
85.81
31%
-45
- C2 -
3R6U
1
OPUBC_BACSU
A:
[12-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q
T
I
K
I
G
A
Q
S
M
S
E
S
E
I
I
A
S
M
L
G
Q
L
I
E
H
H
T
--
D
L
K
T
T
--
T
I
K
N
L
G
S
N
A
V
Q
Q
Q
A
L
M
N
G
E
I
D
I
A
-
A
T
R
-
Y
T
G
D
-
A
L
T
G
T
L
R
M
E
P
E
--
K
D
P
D
K
A
L
A
L
T
Q
R
E
F
K
K
R
Y
D
L
K
W
Y
D
S
Y
G
F
D
N
T
Y
A
F
T
V
S
K
E
L
A
D
Q
Y
H
L
E
T
V
S
D
V
K
K
-
W
A
P
Q
-
L
K
L
G
V
D
N
Y
------
W
M
-
K
L
K
-
G
-
N
G
Y
Q
D
F
T
K
T
Y
G
--------
M
T
F
-
G
-
G
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
S
G
K
M
D
I
V
L
A
Y
S
T
D
G
R
I
K
S
Y
G
L
K
M
L
K
D
D
K
Q
F
F
P
P
Y
D
C
S
P
V
V
P
E
K
V
L
K
E
H
P
E
L
E
G
I
I
K
K
M
L
G
K
I
D
T
A
T
M
Q
E
L
N
Y
E
V
D
G
N
L
K
E
P
S
V
V
A
K
E
Y
L
E
K
H
R
Y
F
E
22
PsiBlast_CBE
85.75
34%
-46
- C2 -
3PPQ
1
OPUCC_BACSU
B:
[41-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
K
I
G
A
Q
S
M
T
E
S
E
I
V
A
N
M
I
A
Q
L
I
E
H
D
T
--
D
L
N
T
A
--
L
V
K
N
L
G
S
N
Y
V
Q
H
Q
A
M
L
G
G
D
I
D
I
S
-
A
T
R
-
Y
S
G
T
D
L
T
S
T
L
G
K
E
A
E
K
---
D
P
K
K
A
L
N
I
V
Q
N
E
F
Q
K
R
F
S
Y
K
W
F
D
S
Y
G
F
D
N
T
Y
A
F
T
V
T
K
K
F
A
E
K
E
H
I
N
T
V
S
D
L
K
K
N
A
-
S
Q
-
Y
K
L
G
V
-
D
N
------
A
W
L
K
R
K
-
G
-
D
G
Y
K
G
F
V
S
T
Y
G
--------
F
E
F
-
G
-
T
T
Y
P
M
Q
I
---
G
L
V
Y
D
A
V
K
N
G
K
M
D
A
V
L
A
Y
S
T
D
G
R
I
K
A
Y
D
L
K
I
L
K
D
D
K
R
F
F
P
P
Y
D
C
S
P
V
I
P
E
K
V
L
K
E
H
P
E
L
E
G
V
I
N
K
L
I
G
Q
I
D
T
E
T
M
Q
E
L
N
Y
E
V
D
G
K
L
K
E
P
S
V
V
A
K
E
F
L
E
K
H
H
Y
F
D
34
HHSearch
85.01
31%
-47
- C2 -
3R6U
1
OPUBC_BACSU
A:
[12-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
T
I
K
I
G
A
Q
S
M
S
E
S
E
I
I
A
S
M
L
G
Q
L
I
E
H
H
T
--
D
L
K
T
T
--
T
I
K
N
L
G
S
N
A
V
Q
Q
Q
A
L
M
N
G
E
I
D
I
A
-
A
-
T
R
Y
T
G
D
-
A
L
T
G
T
L
R
M
E
-
P
-
E
K
D
P
D
K
A
L
A
L
T
Q
R
E
F
K
K
R
Y
D
L
K
W
Y
D
S
Y
G
F
D
N
T
Y
A
F
T
V
S
K
E
L
A
D
Q
Y
H
L
E
T
V
S
D
V
K
K
-
W
A
P
Q
-
L
K
L
G
V
-
D
N
------
Y
W
-
M
K
L
K
G
-
N
G
Y
Q
D
F
T
K
T
Y
G
--------
M
T
F
-
G
G
T
Y
-
P
M
Q
I
---
G
L
V
Y
D
A
V
K
S
G
K
M
D
I
V
L
A
Y
S
T
D
G
R
I
K
S
Y
G
L
K
M
L
K
D
D
K
Q
F
F
P
P
Y
D
C
S
P
V
V
P
E
K
V
L
K
E
H
P
E
L
E
G
I
I
K
K
M
L
G
K
I
D
T
A
T
M
Q
E
L
N
Y
E
V
D
G
N
L
K
E
P
S
V
V
A
K
E
Y
L
E
K
H
R
Y
F
E
28
PsiBlast_CBE
84.81
33%
-44
- C2 -
1SW4
7
?
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
-
E
N
--
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
D
-
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
32
HHSearch
84.73
32%
-47
- C2 -
3O66
2
?
A:
[7-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
N
-
D
V
K
I
T
A
L
S
T
S
E
S
Q
I
I
S
H
M
L
R
L
L
I
E
H
D
T
H
G
K
I
K
P
T
--
L
V
N
N
L
G
S
S
T
I
Q
H
N
A
L
I
N
G
D
A
N
I
S
G
V
-
R
-
Y
N
G
T
-
D
L
T
G
A
L
K
E
A
P
I
--
K
D
P
K
K
A
M
I
A
T
Q
Q
G
F
K
K
K
F
D
Q
T
F
F
D
S
Y
G
F
A
N
T
Y
A
F
M
V
T
K
E
T
A
K
K
Y
H
L
E
T
V
S
D
L
A
K
-
H
S
K
D
-
L
R
L
G
M
-
D
S
------
S
W
-
M
N
--
G
-
D
G
Y
E
G
F
K
K
E
Y
G
--------
F
D
F
-
G
T
V
R
-
P
M
Q
I
---
G
L
V
Y
D
A
L
N
T
E
K
L
D
V
A
L
G
Y
S
T
D
G
R
I
A
A
Y
D
L
K
V
L
K
D
D
K
Q
F
F
P
P
Y
A
A
S
A
V
A
T
N
E
L
L
R
Q
H
P
E
L
K
T
T
I
N
K
L
T
G
K
I
S
T
S
E
M
Q
R
L
N
Y
E
A
D
G
K
G
K
E
P
A
V
V
A
E
E
F
L
K
K
H
H
Y
F
D
30
HHSearch
84.45
34%
-48
- C2 -
1SW5
4
?
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
E
N
---
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
-
K
E
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
-
K
D
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
6
PsiBlast_PDB
84.38
33%
-45
- C2 -
1SW4
7
?
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
-
E
N
--
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
D
-
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
50
Fugue
84.19
34%
-48
- C2 -
1SW5
4
?
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
E
N
---
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
F
A
-
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
-
D
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
8
PsiBlast_PDB
83.90
33%
-43
- C2 -
1SW2
1
?
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
-
E
N
--
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
D
-
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
7
PsiBlast_PDB
83.85
33%
-47
- C2 -
1SW5
4
?
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
-
E
N
--
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
D
-
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
9
PsiBlast_PDB
83.37
33%
-49
- C2 -
3MAM
9
?
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
-
E
N
--
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
A
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
D
-
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
14
PsiBlast_PDB
83.29
27%
-48
- C2 -
4NE4
2
?
A:
[6-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
Q
V
V
V
S
S
K
I
D
T
E
G
G
V
L
G
N
I
I
L
A
V
L
-
N
Q
N
--
K
I
E
T
T
--
D
R
I
Q
L
G
A
T
P
V
V
R
K
A
I
T
A
G
E
I
D
I
Y
-
P
-
E
-
Y
T
G
N
-
A
A
F
F
F
S
K
A
D
D
P
L
W
K
D
A
A
K
G
Y
E
E
A
K
T
L
D
Y
D
A
N
K
I
V
W
L
A
P
S
P
A
N
N
T
W
A
I
A
L
R
K
D
V
A
D
K
N
N
L
K
T
L
S
D
F
G
K
-
Y
----
V
A
G
G
G
-
T
V
V
L
A
A
S
S
E
F
-
V
N
S
-
A
-
A
A
L
P
A
F
Q
T
T
Y
G
F
T
M
K
PDQL
I
T
L
-
S
-
G
G
-
D
T
A
A
---
T
I
A
A
A
A
N
Q
T
N
N
A
N
A
A
M
V
Y
G
T
D
G
G
I
A
P
S
G
L
V
V
L
E
D
D
K
H
V
Q
P
V
Y
Q
P
A
P
I
I
R
E
E
V
L
K
K
H
P
N
I
E
E
L
L
K
P
V
F
E
K
L
D
L
A
T
L
Q
D
L
N
A
R
V
Q
V
G
G
E
Q
A
K
T
V
A
M
D
F
L
T
K
N
G
F
A
K
10
PsiBlast_PDB
82.89
32%
-45
- C2 -
1SW1
6
?
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
R
V
V
I
G
S
K
P
F
N
E
Q
Y
I
L
A
N
M
I
A
I
L
L
E
-
E
N
--
G
Y
K
A
E
--
V
K
E
G
L
G
G
T
L
V
N
Y
E
A
L
K
R
N
D
I
Q
L
Y
-
V
-
E
-
Y
T
G
T
-
A
Y
N
V
I
L
R
K
Q
P
P
E
L
W
D
Q
Q
Y
I
F
D
E
V
K
K
G
L
L
E
A
D
G
V
V
V
A
A
K
L
G
F
R
D
D
Y
A
L
A
V
R
A
D
W
A
E
E
N
G
V
E
K
I
S
D
L
A
E
-
F
A
D
Q
-
L
V
F
G
S
-
D
P
------
E
F
-
A
S
R
-
P
-
D
G
L
P
Q
I
K
K
V
Y
G
--------
F
E
F
K
E
-
V
K
-
Q
M
E
P
---
T
L
M
Y
E
A
I
K
N
K
Q
V
D
V
I
P
A
Y
T
T
D
S
R
V
D
L
F
N
L
K
I
L
E
D
D
K
G
A
L
P
P
Y
D
A
I
I
I
V
N
G
N
T
A
K
D
-
E
K
L
I
S
V
L
K
L
L
E
D
R
I
D
T
D
T
M
R
A
L
N
Y
Q
Y
D
V
E
K
K
D
A
R
E
I
A
M
S
F
L
K
E
Q
G
L
V
K
11
PsiBlast_PDB
82.54
33%
-45
- C2 -
3O66
2
?
A:
[19-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
S
Q
I
I
S
H
M
L
R
L
L
I
E
H
D
T
--
H
G
K
I
K
P
T
L
V
N
N
L
G
S
S
T
I
Q
H
N
A
L
I
N
G
D
A
N
I
S
-
G
V
R
-
Y
N
G
T
-
D
L
T
G
A
L
K
E
A
P
--
I
K
D
P
K
K
A
M
I
A
T
Q
Q
G
F
K
K
K
F
D
Q
T
F
F
D
S
Y
G
F
A
N
T
Y
A
F
M
V
T
K
E
T
A
K
K
Y
H
L
E
T
V
S
D
L
A
K
-
H
-
S
K
D
L
R
L
G
M
-
D
S
------
S
W
-
M
N
---G
D
G
Y
E
G
F
K
K
E
Y
G
--------
F
---
D
-
F
G
-
T
V
R
P
MQI
G
L
V
Y
D
A
L
N
T
E
K
L
D
V
A
L
G
Y
S
T
D
G
R
I
A
A
Y
D
L
K
V
L
K
D
D
K
Q
F
F
P
P
Y
A
A
S
A
V
A
T
N
E
L
L
R
Q
H
P
E
L
K
T
T
I
N
K
L
T
G
K
I
S
T
S
E
M
Q
R
L
N
Y
E
A
D
G
K
G
K
E
P
A
V
V
A
E
E
F
L
K
K
H
H
Y
F
D