@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2113: (2015-12-13 )
MKIVEGVSLHLIKNQQFKTNHLTFRFSGDFNNKTVARRSLVAQMLVTANAKYPKVQEFREKLASLYGASLSTKISTKGLVHIVDIDIVFVKNTFTLEQENIVEQIITFLEDMLFSPLISLEQYQTSIFDTEKKNLIQYLEADIEDNFYSSDLALKSLFYNNKTLRLPKYGTASLVESENSFTAYQEFQKMLKEDQLDIFVVGDFDDYRMIQAFNRMAFEPRHKVLAFDYTQTYENITRSQVEDKDVNQSIMQLAYHLPITYKDEDYFALIVFNGLFGAFAHSLLFTEIREKQGLAYTIGSQFDSFTGLFTIYAGIDKENRERFLKLINKQFNNIKMGRFSSTLLKQTKDILKMNYVLASDNPKVIVDHIYHEHYLDQFHTSALFIDKVDDVTKSDIVSVATKLKLQAFYFLEGN
Atome Classification :
(20 SA)
-----------------------.........10.......--.20......-..30---.---.-....--..40........50---........60.....--------...70........80........90-........100.......110.......120-----....-----------------...130........140-..-.-.-....150.......160........170.....------.----.180-.........190.----......200.....---..210---.-..-.---...220..-..-.--.--.------230-.----.----.-.-.--..---..240...-----.-....250...-...-.260--........270.-.....-------.-----------280--....-----.....290.....-..300.--.----.----....310.--....---.---.320-.........330.-..--....---340.......350.....-.--.-360-.--.....--..-----------370..-.-.-.-.--.-380.......390--------.......400-...-.-.--.--.410..----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MKIVE
G
V
S
L
H
L
I
KNQQFK--TN
H
L
T
F
R
F
S-GDFN---N---
K
-
T
V
A
R
--
R
S
L
V
A
Q
M
L
V
TANAK---YP
K
V
Q
E
F
R
E
K
L
A
S
L
Y--------GASLS
T
K
ISTK
G
L
V
H
I
V
D
I
D
I
V
F
V
K-N
T
F
TL
E
Q
E
N
I
V
E
Q
I
I
T
F
L
E
D
M
L
F
S
P
L
I
S
L
E
Q
-----
Y
Q
T
S
-----------------IFD
T
E
-
K
K
N
L
I
Q
Y
L
E
A
--
D
I-E-D-NFYS
S
D
L
A
L
K
S
L
FYN-NK
T
L
RLPKYG
T
A
S
L
VES------E----NS---
F
T
A
Y
Q
E
F
Q
K
M
L
K
E----DQL
D
I
F
V
V
GDFD
D
Y
---
R
M
I
Q
A
---
F
-
N
R
-M---AFEPRH
K
V
-
L
A
-
F
--
D
--
Y
------
T
---
Q
----
T
----
Y
-
E
-
N
--
I
T
---
R
S
Q-VED
K
-----
D
-
V
N
Q
S
I
M
Q
L
A
Y
-HLP-
I
T
Y---KDE
D
Y
F
A
L
I
VFN-
G
L
F
G
A
-------
F
-----------
A
----
H
S
L
L
-----
F
T
E
I
R
E
KQG
L
A
Y
T
-IGSQF
D
--
S
----
F
----
T
G
L
F
T
I
YA--GID
K
---
E
---
N
R
---
E
R
F
L
K
L
I
N
K
QFNN-IK--MG
R
F
---
S
S
T
L
L
K
Q
T
K
D
I
L
K
M
N
Y
V
L-A--S-DN--
P
--
K
V
I
V
D
--
H
I
-----------
Y
H
E
H
Y
-
L
-
D
-
Q
-F--H-TS
A
L
F
I
DKVDDV
T
--------
K
S
D
I
V
S
V
A
T
K
-
L
K
L
-
Q
-
A
--
F
--
Y
F
L
EGN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.68
36%
-104
- C3 -
3D3Y
8
?
A:
[6-420]
-----------------------
V
Q
L
V
K
G
V
N
L
H
V
I
P
T
E
K
Y
K
--
T
V
R
L
L
V
R
F
N
-
T
R
L
N
---
H
---
E
-
T
I
T
K
--
R
T
L
L
S
S
L
M
E
T
N
S
L
N
---
Y
P
N
Q
V
K
L
S
E
R
L
A
E
L
Y
--------
G
A
S
F
G
I
G
V
S
K
K
G
N
Q
H
W
F
N
I
S
M
N
I
V
N
-
D
H
Y
-
L
Q
D
S
Q
V
L
A
E
A
V
D
F
L
K
E
I
I
F
A
P
N
I
Q
A
G
Q
-----
F
E
A
E
-----------------
T
F
Q
R
E
-
K
E
N
L
K
A
Y
L
E
S
--
I
V
-
E
-
D
-
K
Q
T
Y
A
S
L
A
L
Q
S
V
Y
F
N
Q
S
E
D
Q
K
I
P
S
F
G
T
V
A
A
L
A
E
------
E
----
T
A
---
A
S
L
A
A
Y
Y
Q
K
M
L
A
E
----
D
Q
V
D
I
F
V
L
G
D
V
N
E
A
---
E
L
V
P
L
---
F
-
K
Q
-
L
---
P
F
T
P
R
E
E
G
K
A
A
-
I
--
F
--
Y
------
N
---
Q
----
P
----
I
-
R
-
N
--
V
I
---
E
E
R
-
T
E
R
E
-----
V
-
L
A
Q
S
K
L
N
L
A
Y
-
N
T
D
-
I
Y
Y
---
G
D
S
Y
Y
F
A
L
Q
V
F
N
-
G
I
F
G
G
-------
F
-----------
P
----
H
S
K
L
-----
F
M
N
V
R
E
K
E
H
L
A
Y
Y
-
A
S
S
S
I
D
--
T
----
F
----
R
G
F
M
T
V
Q
T
--
G
I
D
G
---
K
---
N
R
---
N
Q
V
L
R
L
I
S
T
E
L
E
N
-
I
R
--
L
G
K
I
---
R
E
L
E
I
E
Q
T
K
A
M
L
K
N
Q
Y
I
L
-
A
--
L
-
D
N
--
A
--
G
A
W
L
E
--
K
E
-----------
Y
L
N
E
L
-
M
-
P
-
Q
-
T
--
M
L
T
A
E
E
W
I
A
R
I
N
A
V
T
--------
I
P
E
I
Q
E
V
A
K
R
-
L
E
L
-
Q
-
A
--
I
--
F
F
L
E
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
97.12
36%
-97
- C3 -
3D3Y
8
?
A:
[6-421]
-----------------------
V
Q
L
V
K
G
V
N
L
H
V
I
P
T
E
K
Y
K
--
T
V
R
L
L
V
R
F
N
-
T
R
L
N
---
H
---
E
-
T
I
T
K
--
R
T
L
L
S
S
L
M
E
T
N
S
L
N
---
Y
P
N
Q
V
K
L
S
E
R
L
A
E
L
Y
--------
G
A
S
F
G
I
G
V
S
K
K
G
N
Q
H
W
F
N
I
S
M
N
I
V
N
-
D
H
Y
L
Q
D
-
S
Q
V
L
A
E
A
V
D
F
L
K
E
I
I
F
A
P
-----
N
IQAGQ
F
E
A
E
-----------------
T
F
Q
R
E
-
K
E
N
L
K
A
Y
L
E
S
--
I
V
-
E
-
D
-
K
Q
T
Y
A
S
L
A
L
Q
S
V
Y
F
N
Q
S
E
D
Q
K
I
P
S
F
G
T
V
A
A
L
A
E
------
E
----
T
A
---
A
S
L
A
A
Y
Y
Q
K
M
L
A
E
----
D
Q
V
D
I
F
V
L
G
D
V
N
E
A
---
E
L
V
P
L
---
F
K
Q
L
-
P
---
F
T
P
R
E
E
G
K
-
A
A
-
I
--
F
--
Y
------
N
---
Q
----
P
----
I
-
R
-
N
--
V
I
---
E
E
R
-
T
E
R
E
-----
V
-
L
A
Q
S
K
L
N
L
A
Y
-
N
T
D
-
I
Y
Y
---
G
D
S
Y
Y
F
A
L
Q
V
F
N
-
G
I
F
G
G
-------
F
-----------
P
----
H
S
K
L
-----
F
M
N
V
R
E
K
E
H
L
A
Y
Y
-
A
S
S
S
I
D
--
T
----
F
----
R
G
F
M
T
V
Q
T
--
G
I
D
G
---
K
---
N
R
---
N
Q
V
L
R
L
I
S
T
E
L
E
N
-
I
R
--
L
G
K
I
---
R
E
L
E
I
E
Q
T
K
A
M
L
K
N
Q
Y
I
L
-
A
--
L
-
D
N
--
A
--
G
A
W
L
E
--
K
E
-----------
Y
L
N
E
L
-
M
-
P
Q
T
-
M
--
L
-
T
A
E
E
W
I
A
R
I
N
A
V
T
--------
I
P
E
I
Q
E
V
A
K
R
-
L
E
L
-
Q
-
A
--
I
--
F
F
L
E
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
72.08
20%
-81
- C3 -
3HDI
7
?
A:
[5-402]
-----------------------
M
T
L
D
N
G
V
R
I
I
T
E
K
M
S
T
V
R
--
S
V
S
I
G
I
W
V
G
-
T
G
S
R
---
Y
ESA
E
-
E
N
G
I
--
S
H
F
L
E
H
M
F
F
K
G
T
N
T
---
R
S
-
A
Q
E
I
A
E
F
F
D
S
I
---------
G
G
Q
V
N
A
F
T
S
K
E
----
Y
T
C
Y
Y
A
K
V
L
D
-
D
--------
H
A
G
Q
A
I
D
T
L
S
D
M
F
F
H
S
-----
T
-----
F
Q
K
E
-----------------
E
L
E
K
E
-
R
K
V
V
F
E
E
I
K
M
--
V
D
-
D
-
T
-
P
D
D
I
V
H
D
L
L
S
S
A
T
Y
G
-
K
H
S
L
G
Y
P
I
L
G
T
V
E
T
L
N
S
------
F
----
N
E
---
G
M
L
R
H
Y
M
D
R
F
Y
T
G
----
D
Y
V
V
I
S
V
A
G
N
V
H
D
----
E
L
I
D
K
---
I
K
E
T
-
F
---
S
Q
V
K
P
T
T
Y
-
N
Y
-
Q
-----
G
------
E
---
K
----
P
----
M
-
F
-
L
--
P
N
---
R
-
I
-
V
R
K
K
-----
E
-
T
E
Q
A
H
L
C
L
G
Y
-
P
G
L
--
P
I
---
G
D
K
D
V
Y
A
L
V
L
L
N
-
N
V
L
G
G
-------
S
-----------
M
----
S
S
R
L
-----
F
Q
D
I
R
E
K
R
G
L
C
Y
S
-
V
F
S
Y
H
S
--
S
F
R--
D
----
S
G
M
L
T
I
Y
A
--
G
T
G
H
---
D
---
Q
L
---
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
---
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
-
S
--
L
-
E
S
--
T
--
N
S
R
M
S
--
R
N
-----------
G
K
N
E
L
-
L
L
K
-
K
-
H
--
R
-
S
L
D
E
M
I
E
Q
I
N
A
V
Q
--------
K
Q
D
V
S
R
L
A
K
I
-
L
L
S
-
A
S
P
--
S
--
I
S
L
I
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
70.82
17%
-73
- C3 -
3AMJ
-
?
B:
[7-403]
-----------------------
W
T
A
P
S
G
A
Q
V
Y
Y
V
E
N
R
T
L
P
--
M
L
D
V
Q
V
D
F
D
-
A
G
S
A
---
R
EPA
D
-
Q
V
G
V
--
A
S
M
T
A
S
L
M
D
A
G
T
G
S
G
KS
A
L
D
E
N
A
I
A
D
R
L
A
D
I
---------
G
A
R
L
G
G
G
A
E
A
D
----
R
A
S
F
S
L
R
V
L
S
-
S
P
------
A
E
R
N
S
A
L
T
I
L
R
D
I
L
A
H
P
-----
T
-----
F
P
A
P
-----------------
V
L
E
R
E
-
R
A
R
A
I
A
G
L
R
E
--
A
Q
-
T
-
Q
-
P
G
S
I
L
G
R
R
F
T
E
L
A
Y
G
-
K
H
P
Y
G
H
V
--
S
S
V
A
T
L
Q
K
------
I
----
S
R
---
D
Q
L
V
S
F
H
R
T
H
Y
V
A
----
R
T
A
V
V
T
L
V
G
D
I
T
R
A
---
E
A
E
T
I
---
A
Q
Q
L
-
T
---
A
D
L
P
A
G
A
T
-
L
P
-
P
--
L
--
P
------
D
---
P
----
A
----
M
-
P
-
R
--
A
T
---
V
E
R
-
I
-
A
N
-----
P
-
A
T
Q
A
H
I
A
I
G
M
-
P
T
L
-
K
-
R
---
G
D
P
D
F
F
P
L
V
V
G
N
-
Y
A
L
G
G
G------
G
-----------
F
----
E
S
R
L
-----
M
K
E
I
R
D
K
R
G
L
S
Y
G
-
A
Y
S
Y
F
S
--
P
Q
K--
S
----
M
G
L
F
Q
I
G
F
--
E
T
R
A
---
E
---
K
A
---
D
E
A
V
Q
V
A
N
D
T
L
D
A
-
F
L
--
R
E
G
P
---
T
D
A
E
L
Q
A
A
K
D
N
L
I
N
G
F
A
L
-
R
--
L
-
D
S
--
N
--
A
K
I
L
G
--
Q
V
-----------
A
V
I
G
Y
-
Y
-
G
-
L
P
L
--
D
-
Y
L
D
H
Y
T
E
R
V
Q
A
V
T
--------
V
E
Q
V
R
E
A
F
A
R
-
H
V
K
-
R
-
E
--
N
--
L
I
T
V
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
70.30
14%
-76
* C3 *
3AMI
-
?
A:
[36-437]
-----------------------
T
T
L
P
N
G
L
K
V
V
V
R
E
D
H
R
A
P
--
T
L
V
H
M
V
W
Y
R
-
V
G
S
M
---
D
ETT
G
-
T
T
G
V
--
A
H
A
L
E
H
M
M
F
K
G
T
K
D
---
V
G
-
P
G
E
F
S
K
R
V
A
A
M
---------
G
G
R
D
N
A
F
T
T
R
D
----
Y
T
A
Y
Y
Q
Q
V
P
S
-
S
--------
R
L
S
D
V
M
G
L
E
A
D
R
M
A
N
L
-----
V
-----
V
D
D
E
-----------------
L
F
K
K
E
-
I
Q
V
I
A
E
E
R
R
W
--
R
T
D
D
-
K
-
P
R
S
K
A
Y
E
A
L
M
A
A
S
Y
V
-
A
H
P
Y
R
V
P
V
I
G
W
M
N
D
I
Q
N
------
M
----
T
A
---
Q
D
V
R
D
W
Y
K
R
W
Y
G
P
----
N
N
A
T
V
V
V
V
G
D
V
E
H
E
---
A
V
F
R
L
---
A
E
Q
T
-
Y
---
G
K
L
A
R
V
E
A
-
P
A
R
K
--
Q
--
Q
------
G
---
E
----
P
----
Q
Q
A
-
G
--
V
R
---
R
V
T
-
V
-
K
A
-----
P
-
A
E
L
P
Y
L
A
L
A
W
-
H
V
P
-
A
I
V
DLD
K
S
R
D
A
Y
A
L
E
I
L
A
-
A
V
L
D
G
-------
Y
-----------
D
----
G
A
R
M
-----
T
R
Q
L
V
R
G
N
K
H
A
V
S
-
A
G
A
G
Y
D
--
S
LSRG
Q
----
Q
G
L
F
I
L
E
G
--
V
P
S
K
G--
V
---
T
I
---
A
Q
L
E
T
D
L
R
A
Q
V
R
D
-
I
A
--
A
K
G
V
---
T
E
A
E
L
S
R
V
K
S
Q
M
V
A
G
K
V
Y
-
E
--
Q
-
D
S
--
L
--
M
G
Q
A
T
--
Q
I
-----------
G
G
L
E
V
-
L
-
G
L
S
-
W
--
R
-
D
D
D
R
F
Y
Q
Q
L
R
S
V
T
--------
A
A
E
V
K
A
A
A
A
R
-
L
L
T
-
D
-
D
--
T
--
L
T
V
A
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
67.58
17%
-78
- C3 -
1HR6
1
MPPB_YEAST
B:
[10-426]
-----------------------
S
K
L
P
N
G
L
T
I
A
T
E
Y
I
P
N
T
S
--
S
A
T
V
G
I
F
V
D
-
A
G
S
R
---
A
ENV
K
-
N
N
G
T
--
A
H
F
L
E
H
L
A
F
K
G
T
Q
N
---
R
P
-
Q
Q
G
I
E
L
E
I
E
N
I
---------
G
S
H
L
N
A
Y
T
S
R
E
----
N
T
V
Y
Y
A
K
S
L
Q
-
E
--------
D
I
P
K
A
V
D
I
L
S
D
I
L
T
K
S
-----
V
-----
L
D
N
S
-----------------
A
I
E
R
E
-
R
D
V
I
I
R
E
S
E
E
--
V
D
-
K
-
M
-
Y
D
E
V
V
F
D
H
L
H
E
I
T
Y
K
-
D
Q
P
L
G
R
T
I
L
G
P
I
K
N
I
K
S
------
I
----
T
R
---
T
D
L
K
D
Y
I
T
K
N
Y
K
G
----
D
R
M
V
L
A
G
A
G
A
V
D
H
E
---
K
L
V
Q
Y
---
A
Q
K
Y
-
F
---
G
H
V
P
K
S
E
S
-
P
V
-
P
--
L
GS
P
------
R
GP
L
P
----
V
----
F
-
C
-
R
--
G
E
---
R
-
F
-
I
K
E
N
-----
T
-
L
P
T
T
H
I
A
I
A
L
-
E
G
V
--
S
W
---
S
A
P
D
Y
F
V
A
L
A
T
Q
-
A
I
V
G
N
W
D
RAIGT
G
TN---------
S
----
P
S
P
L
-----
A
V
A
A
S
Q
N
G
S
L
A
N
S
-
Y
M
S
F
S
T
--
S
Y
A--
D
----
S
G
L
W
G
M
Y
I
V
T
D
S
N
E
---
H
---
N
V
---
R
L
I
V
N
E
I
L
K
E
W
K
R
-
I
K
--
S
G
K
I
---
S
D
A
E
V
N
R
A
K
A
Q
L
K
A
A
L
L
L
-
S
--
L
-
D
G
--
S
--
T
A
I
V
E
--
D
I
-----------
G
R
Q
V
V
-
T
T
G
-
K
-
R
--
L
-
S
P
E
E
V
F
E
Q
V
D
K
I
T
--------
K
D
D
I
I
M
W
A
N
Y
-
R
L
Q
-
N
-
K
--
P
V
S
M
V
A
L
G
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
67.19
13%
-75
- C3 -
1HR6
1
MPPA_YEAST
A:
[9-416]
-----------------------
S
S
L
A
N
G
L
K
V
A
T
S
N
T
P
G
-
H
--
F
S
A
L
G
L
Y
I
D
-
A
G
S
R
---
F
EGR
N
-
L
K
G
C
--
T
H
I
L
D
R
L
A
F
K
S
T
E
H
---
V
E
-
G
R
A
M
A
E
T
L
E
L
L
---------
G
G
N
Y
Q
C
T
S
S
R
E
----
N
L
M
Y
Q
A
S
V
F
N
-
Q
--------
D
V
G
K
M
L
Q
L
M
S
E
T
V
R
F
P
-----
K
-----
I
T
E
Q
-----------------
E
L
Q
E
Q
-
K
L
S
A
E
Y
E
I
D
E
--
V
W
-
M
-
K
-
P
E
L
V
L
P
E
L
L
H
T
A
A
Y
S
-
G
E
T
L
G
S
P
L
I
C
P
R
G
L
I
P
S
------
I
----
S
K
---
Y
Y
L
L
D
Y
R
N
K
F
Y
T
P
----
E
N
T
V
A
A
F
V
G
-
V
P
H
E
---
K
A
L
E
L
---
T
G
K
Y
-
L
---
G
D
W
Q
S
T
H
P
-
P
I
-
T
--
K
K
-
V
------
A
---
Q
----
Y
----
T
-
G
-
G
--
E
S
C
I
P
P
A
P
-
V
F
G
N
-----
L
-
P
E
L
F
H
I
Q
I
G
F
-
E
G
L
-
P
-
I
---
D
H
P
D
I
Y
A
L
A
T
L
Q
-
T
L
L
G
G
-------
G
G
S
F
S
A
G
G
P
GKG
M
----
Y
S
R
L
-----
Y
T
H
V
L
N
Q
Y
Y
F
V
E
N
-
C
V
A
F
N
H
--
S
Y
S--
D
----
S
G
I
F
G
I
S
L
--
S
C
I
P
---
Q
---
A
A
---
P
Q
A
V
E
V
I
A
Q
Q
M
Y
N
T
F
A
NK
D
L
R
L
---
T
E
D
E
V
S
R
A
K
N
Q
L
K
S
S
L
L
M
-
N
--
L
-
E
S
--
K
--
L
V
E
L
E
--
D
M
-----------
G
R
Q
V
L
-
M
H
G
-
R
-
K
--
I
-
P
V
N
E
M
I
S
K
I
E
D
L
K
--------
P
D
D
I
S
R
V
A
E
M
-
I
F
T
-
G
-
N
--
V
--
N
N
A
G
N
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
63.39
15%
-74
- C3 -
3CX5
1
CYC1_YEAST (first)
A:
[4-409]
-----------------------
T
Q
L
S
N
G
I
V
V
A
T
E
H
N
P
S
A
H
--
T
A
S
V
G
V
V
F
G
-
S
G
A
A
---
N
ENP
Y
-
N
N
G
V
--
S
N
L
W
K
N
I
F
L
S
K
E
N
S
-----------
A
V
A
A
K
-
E
--------
G
L
A
L
S
S
N
I
S
R
D
----
F
Q
S
Y
I
V
S
S
L
P
-
G
--------
S
T
D
K
S
L
D
F
L
N
Q
S
F
I
Q
Q
K
--
A
N
L
-----
L
S
S
S
-----------------
N
F
E
A
T
-
K
K
S
V
L
K
Q
V
Q
D
--
F
E
-
D
-
N
D
H
P
N
R
V
L
E
H
L
H
S
T
A
F
Q
-
N
T
P
L
S
L
P
T
R
G
T
L
E
S
L
E
N
------
L
----
V
V
---
A
D
L
E
S
F
A
N
N
H
F
L
N
----
S
N
A
V
V
V
G
T
G
N
I
K
H
E
---
D
L
V
N
S
---
I
E
S
K
-
N
---
L
S
L
Q
T
G
T
K
-
P
V
-
L
--
K
--
K
------
K
---
A
----
A
----
F
-
L
-
G
--
S
E
---
V
R
L
-
R
-
D
D
-----
T
-
L
P
K
A
W
I
S
L
A
V
-
E
G
E
-
P
V
----
N
S
P
N
Y
F
V
A
K
L
A
A
-
Q
I
F
G
S
-------
Y
-----------
N
AFE
P
A
S
R
L
QGI
K
L
L
D
N
I
Q
E
Y
-
Q
L
C
D
N
-
F
N
H
F
S
L
--
S
YK--
D
----
S
G
L
W
G
F
S
T
--
A
T
R
N
---
V
T--
M
I
---
D
D
L
I
H
F
T
L
K
Q
W
N
R
-
L
T
---
I
S
V
---
T
D
T
E
V
E
R
A
K
S
L
L
K
L
Q
L
G
Q
-
L
--
Y
-
E
S
--
G
N
P
V
N
D
A
N
--
L
L
-----------
G
A
E
V
L
I
K
-
G
-
S
-
K
--
L
-
S
L
G
E
A
F
K
K
I
D
A
I
T
--------
V
K
D
V
K
A
W
A
G
K
-
R
L
W
-
D
-
Q
--
D
--
I
A
I
A
G
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
63.30
13%
-78
- C3 -
1PP9
2
QCR1_BOVIN
A:
[17-426]
-----------------------
S
Q
L
D
N
G
L
R
V
A
S
E
Q
S
S
-
Q
P
--
T
C
T
V
G
V
W
I
D
-
A
G
S
R
---
Y
ESE
K
-
N
N
G
A
--
G
Y
F
V
E
H
L
A
F
K
G
T
K
N
---
R
P
-
G
N
A
L
E
K
E
V
E
S
M
---------
G
A
H
L
N
A
Y
S
T
R
E
----
H
T
A
Y
Y
I
K
A
L
S
-
K
--------
D
L
P
K
A
V
E
L
L
A
D
I
V
Q
N
C
-----
S
-----
L
E
D
S
-----------------
Q
I
E
K
E
-
R
D
V
I
L
Q
E
L
Q
E
--
N
D
-
T
-
S
-
M
R
D
V
V
F
N
Y
L
H
A
T
A
F
Q
-
G
T
P
L
A
Q
S
V
E
G
P
S
E
N
V
R
K
------
L
----
S
R
---
A
D
L
T
E
Y
L
S
R
H
Y
K
A
----
P
R
M
V
L
A
A
A
G
G
L
E
H
R
---
Q
L
L
D
L
---
A
Q
K
H
-
F
---
S
G
L
S
G
T
Y
D
-
E
D
-
A
--
V
--
P
------
T
L
--
S
----
P
----
C
R
F
-
T
--
G
S
---
Q
I
C
-
H
R
E
D
-----
G
-
L
P
L
A
H
V
A
I
A
V
-
E
G
P
-
G
-
W
---
A
H
P
D
N
V
A
L
Q
V
A
N
-
A
I
I
G
H
-------
Y
D
CTYGGGAH--
L
----
S
S
P
L
-----
A
S
-
I
A
A
T
N
K
L
C
Q
S
-
F
Q
T
F
N
I
C
Y
A
----
D
----
T
G
L
L
G
A
H
F
--
V
C
D
H
---
M
---
S
I
---
D
D
M
M
F
V
L
Q
G
Q
W
M
R
-
L
C
---
T
S
A
---
T
E
S
E
V
L
R
G
K
N
L
L
R
N
A
L
V
S
-
H
--
L
-
D
G
--
T
--
T
P
V
C
E
--
D
I
-----------
G
R
S
L
L
T
Y
-
G
-
R
-
R
--
I
-
P
L
A
E
W
E
S
R
I
A
E
V
D
--------
A
R
V
V
R
E
V
C
S
K
-
Y
F
Y
-
D
-
Q
C
P
A
--
V
A
G
F
G
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.95
25%
-86
- C3 -
3HDI
7
?
A:
[97-388]
------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
I
D
T
L
S
D
M
F
F
H
-----
S
T
-----
F
Q
K
E
-----------------
E
L
E
K
E
-
R
K
V
V
F
E
E
I
K
M
V
D
D
T
-
P
-
D
-
D
I
V
H
-
D
L
-
L
S
S
A
T
Y
G
-
K
H
S
L
G
Y
P
I
L
G
T
V
E
T
L
N
S
------
F
----
N
E
---
G
M
L
R
H
Y
M
D
R
F
Y
T
G
----
D
Y
V
V
I
S
V
A
G
N
V
H
D
E
L
I
D
K
I
K
E
T
---
F
-
S
Q
-
V
---------
K
P
-
T
T
-
Y
--
N
--
Y
------
Q
---
G
----
E
----
K
-
P
-
M
--
F
L
---
P
N
R
I
V
R
K
K
-----
E
-
T
E
Q
A
H
L
C
L
G
Y
P
G
L
P
-
I
-----
G
D
K
D
V
Y
A
L
V
L
L
N
-
N
V
L
G
G
-------
S
-----------
M
----
S
S
R
L
-----
F
Q
D
I
R
E
K
R
G
L
C
Y
S
-
V
F
S
Y
H
S
--
S
----
F
RD--
S
G
M
L
T
I
Y
A
--
G
T
G
H
---
D
---
Q
L
---
D
D
L
V
Y
S
I
Q
E
T
T
S
A
-
L
A
--
E
K
G
L
---
T
E
K
E
L
E
N
G
K
E
Q
L
K
G
S
L
M
L
-
S
LE
S
-
T
N
--
S
--
R
M
S
R
N
--
G
------------
K
N
E
L
L
-
L
-
K
-
K
-
H
--
R
-
S
L
D
E
M
I
E
Q
I
N
A
V
Q
--------
K
Q
D
V
S
R
L
A
K
I
-
L
L
S
-
A
-
S
--
P
--
S
I
S
L
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
61.23
12%
-84
- C3 -
3CWW
5
IDE_HUMAN
A:
[38-447]
-----------------------
L
E
L
A
N
G
I
K
V
L
L
I
S
D
P
T
T
D
--
K
S
S
A
A
L
D
V
H
-
I
G
S
L
---
S
DPP
N
-
I
A
G
L
--
S
H
F
L
Q
H
M
L
F
L
G
T
K
K
---
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
H
---------
A
G
S
S
N
A
F
T
S
G
E
----
H
T
N
Y
Y
F
D
V
S
H
-
E
--------
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
S
P
-----
L
-----
F
D
E
S
-----------------
A
K
D
R
E
-
V
N
A
V
D
S
E
H
E
K
--
N
V
-
M
-
N
-
D
A
W
R
L
F
Q
L
E
K
A
T
G
N
P
-
K
H
P
F
S
K
F
G
T
G
N
K
Y
T
L
E
T
R
P
N
Q
E
G
I
D---
V
R
---
Q
E
L
L
K
F
H
S
A
Y
Y
S
S
----
N
L
M
A
V
V
V
L
G
R
E
S
L
D
---
D
L
T
N
L
---
V
V
K
L
-
F
---
S
E
V
E
N
K
N
V
-
P
L
-
P
--
E
--
F
------
P
E--
H
----
P
----
F
-
Q
-
E
EH
L
K
---
Q
L
Y
-
K
I
V
P
-----
I
-
K
D
I
R
N
L
Y
V
T
F
-
P
I
P
-
D
L
Q
---
K
Y
Y
K
S
N
P
G
H
Y
L
G
-
H
L
I
G
H
-------
E
-----------
G
----
P
G
S
L
-----
L
S
E
L
K
S
K
-
G
W
V
N
T
-
L
V
G
G
Q
K
--
A
G
A
R-
G
----
F
M
F
F
I
I
N
V
--
D
L
T
E
---
E
G
L
L
H
V
---
E
D
I
I
L
H
M
F
Q
Y
I
Q
K
-
L
R
--
A
E
G
P
---
Q
E
W
V
F
Q
E
L
K
D
L
N
A
V
A
F
R
F
K
D
--
K
-
E
R
--
P
--
R
G
Y
T
S
--
K
I
-----------
A
G
I
L
H
-
Y
-
Y
-
P
-
L
--
E
-
E
V
L
T
A
E
Y
L
L
E
E
F
R
--------
P
D
L
I
E
M
V
L
D
K
-
L
R
P
-
E
-
N
--
V
--
R
V
A
I
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
57.05
12%
-72
- C3 -
2FGE
3
PREP1_ARATH
A:
[42-471]
------------------------
H
K
K
T
G
C
E
V
M
S
V
S
N
E
D
E
N
--
K
V
F
-
G
V
V
F
R
-
T
P
-
P
---
K
---
D
-
S
T
G
I
--
P
H
I
L
Q
H
S
V
L
C
G
S
R
K
---
Y
P
V
K
E
P
F
V
E
L
L
K
G
S
L
--------
H
T
F
L
N
A
F
T
Y
P
D
----
R
T
C
Y
P
V
A
S
T
N
T
K
--------
D
F
Y
N
L
V
D
V
Y
L
D
A
V
F
F
P
-----
K
-----
C
V
D
D
A
H
T
F
Q
Q
E
G
W
H
Y
E
L
NDPS
E
D
I
S
Y
-
K
G
V
V
F
N
E
M
K
G
--
V
Y
-
S
-
Q
-
P
D
N
I
L
G
R
I
A
Q
Q
A
L
S
P
-
E
N
T
Y
G
V
D
S
G
G
D
P
K
D
I
P
N
------
L
----
T
F
---
E
E
F
K
E
F
H
R
Q
Y
Y
H
P
----
S
N
A
R
I
W
F
Y
G
D
D
D
P
V
---
H
R
L
R
V
---
L
S
E
Y
-
L
---
D
M
F
E
A
S
P
S
-
P
N
-
S
S
K
I
--
K
------
F
Q
--
K
----
L
----
F
-
S
-
E
--
P
V
---
R
L
V
-
E
K
Y
P
AGRDG
D
L
K
K
K
H
M
L
C
V
N
W
-
L
L
S
-
E
K
P
L--
D
L
Q
T
Q
L
A
L
G
F
L
D
-
H
L
M
L
G
-------
T
-----------
P
----
A
S
P
L
-----
R
K
I
L
L
E
S
-
G
L
G
E
A
L
V
S
S
G
L
S
DE
L
----
L
----
Q
P
Q
F
G
I
G
L
K
-
G
V
S
E
---
E
---
N
V
---
Q
K
V
E
E
L
I
M
D
T
L
K
K
-
L
A
--
E
E
G
F
---
D
N
D
A
V
E
A
S
M
N
T
I
E
F
S
L
R
E
-
N
--
N
-
T
G
SF
P
--
R
G
L
S
L
M
L
Q
S
-----------
I
S
K
W
I
-
Y
-
D
M
D
-
P
--
F
-
E
P
L
K
Y
T
E
P
L
K
A
L
K
T
R
I
A
E
EGS
K
A
V
F
S
P
L
I
E
K
-
L
I
L
-
N
-
N
--
S
--
H
R
V
T
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
56.53
13%
-101
- C- -
1PP9
1
QCR2_BOVIN
B:
[27-429]
-----------------------
T
R
L
P
N
G
L
V
I
A
S
L
E
N
Y
-
A
P
--
A
S
R
I
G
L
F
I
K
-
A
G
S
R
---
Y
ENS
N
-
N
L
G
T
--
S
H
L
L
R
L
A
S
S
L
T
T
K
G
---
A
S
-
S
F
K
I
T
R
G
I
E
A
V
---------
G
G
K
L
S
V
T
S
T
R
E
----
N
M
A
Y
T
V
E
C
L
R
-
D
--------
D
V
D
I
L
M
E
F
L
L
N
V
T
T
A
P
-----
E
-----
F
R
R
W
-----------------
E
V
A
A
L
-
Q
P
Q
L
R
I
D
K
A
V
--
A
L
-
Q
-
N
-
P
Q
A
H
V
I
E
N
L
H
A
A
A
Y
R
--
N
A
L
A
N
S
L
Y
C
P
D
Y
R
I
G
K
------
V
----
T
P
---
V
E
L
H
D
Y
V
Q
N
H
F
T
S
----
A
R
M
A
L
I
G
L
G
-
V
S
H
P
---
V
L
-
K
Q
---
V
A
E
Q
-
F
---
L
N
I
R
G
G
L
G
-
L
S
-
G
-----
A
------
K
---
A
----
K
----
Y
-
H
-
G
--
G
E
---
I
-
R
-
E
-
Q
N
-----
G
-
D
S
L
V
H
A
A
L
V
A
-
E
S
A
-
A
-
I
---
G
S
A
E
A
N
A
F
S
V
L
Q
-
H
V
L
G
A
-------
G
PHVKRGSN---
A
----
T
S
S
L
-----
Y
Q
A
V
A
K
G
V
H
Q
P
F
D
-
V
S
A
F
N
A
S
Y
S
----
D
----
S
G
L
F
G
F
Y
T
--
I
S
Q
A
---
A
---
S
A
---
G
D
V
I
K
A
A
Y
N
Q
V
K
T
-
I
A
--
Q
G
N
L
---
S
N
P
D
V
Q
A
A
K
N
K
L
K
A
G
Y
L
M
-
S
--
V
-
E
S
--
S
--
E
G
F
L
D
--
E
V
-----------
G
S
Q
A
L
-
A
-
A
G
S
-
Y
--
T
-
P
P
S
T
V
L
Q
Q
I
D
A
V
A
--------
D
A
D
V
I
N
A
A
K
K
-
F
V
S
G
R
-
K
--
S
--
M
A
A
S
G
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
55.93
10%
-83
- C3 -
1Q2L
3
PTRA_ECOLI
A:
[24-431]
-----------------------
I
R
L
D
N
G
M
V
V
L
L
V
S
D
P
Q
A
V
--
K
S
L
S
A
L
V
V
P
-
V
G
S
L
---
E
DPE
A
-
Y
Q
G
L
--
A
H
Y
L
E
H
M
S
L
M
G
S
K
K
---
Y
P
Q
A
D
S
L
A
E
Y
L
K
M
H
---------
G
G
S
H
N
A
S
T
A
P
Y
----
R
T
A
F
Y
L
E
V
E
N
-
D
--------
A
L
P
G
A
V
D
R
L
A
D
A
I
A
E
P
-----
L
-----
L
D
K
K
-----------------
Y
A
E
R
E
-
R
N
A
V
N
A
E
L
T
M
--
A
R
-
T
-
R
-
D
G
M
R
M
A
Q
V
S
A
E
T
I
N
P
-
A
H
P
G
S
K
F
S
G
G
N
L
E
T
L
S
D
------
K
PGNP
V
Q
---
Q
A
L
K
D
F
H
E
K
Y
Y
S
A
----
N
L
M
K
A
V
I
Y
S
N
K
P
L
P
---
E
L
A
K
M
---
A
A
D
T
-
F
---
G
R
V
P
N
K
E
S
-
K
K
-
P
--
E
IT
V
------
P
---
V
----
V
----
T
-
D
A
Q
--
K
G
---
I
I
I
-
H
Y
V
P
-----
A
-
L
P
R
K
V
L
R
V
E
F
-
R
I
D
-
N
N
S
---
A
K
F
R
S
K
T
D
E
L
I
T
-
Y
L
I
G
N
-------
R
-----------
S
----
P
G
T
L
-----
S
D
W
L
Q
K
-
Q
G
L
V
E
G
-
I
S
A
N
S
D
--
P
IVNG
N
----
S
G
V
L
A
I
S
A
--
S
L
T
D
K
G
L
A
---
N
R
---
D
Q
V
V
A
A
I
F
S
Y
L
N
L
-
L
R
--
E
K
G
I
---
D
K
Q
Y
F
D
E
L
A
N
V
L
D
I
D
F
R
Y
-
P
--
S
I
T
R
--
D
--
M
D
Y
V
E
--
W
L
-----------
A
D
T
M
I
-
R
-
V
-
P
-
V
--
E
-
H
T
L
D
A
V
N
I
A
D
R
Y
D
--------
A
K
A
V
K
E
R
L
A
M
-
M
T
P
-
Q
-
N
--
A
--
R
I
W
Y
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.71
25%
-103
- C3 -
3AMJ
-
?
B:
[228-393]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
---
R
A
T
-
V
E
R
I
-----
A
-
N
P
A
T
Q
A
H
I
A
I
-
G
M
P
T
L
K
R
---
G
D
P
D
F
F
P
L
V
V
G
N
Y
A
L
G
G
G
-------
G
-----------
F
----
E
S
R
L
-----
M
K
E
I
R
D
K
R
G
L
S
Y
G
-
A
Y
S
Y
F
S
--
P
Q
K--
S
----
M
G
L
F
Q
I
G
F
--
E
T
R
A
---
E
---
K
A
---
D
E
A
V
Q
V
A
N
D
T
L
D
A
-
F
L
--
R
E
G
P
---
T
D
A
E
L
Q
A
A
K
D
N
L
I
N
G
F
A
L
-
R
--
L
-
D
S
--
N
--
A
K
I
L
G
--
Q
V
A
V
I
G
Y
Y
GLPLD
Y
L
D
H
Y
-
T
-
E
-
R
-
V
--
Q
---
A
V
T
V
E
Q
V
R
E
A
F
--------
A
R
H
V
K
R
E
N
L
I
-
T
V
V
-
V
-
G
--
G
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
54.67
11%
-62
- C3 -
1BGY
-
QCR2_BOVIN
B:
[21-439]
--------------------------
P
Q
----------
D
L
E
--
F
T
R
L
P
N
G
L
V
-
I
A
S
L
---
E
---
N
-
Y
A
P
A
--
S
R
I
G
L
F
I
K
A
G
S
R
Y
E
---
N
S
N
N
L
G
T
S
H
L
L
R
L
A
S
SLTTKGAS
S
F
K
I
T
R
G
I
E
A
V
G
G
K
L
S
V
T
S
T
R
E
N
M
A
-
Y
T
V
E
C
L
R
D
D
V
-
D
I
L
M
E
F
L
L
N
V
T
T
A
P
-----
E
-----
F
R
R
W
-----------------
E
V
A
A
L
-
Q
P
Q
L
R
I
D
K
A
V
--
A
L
-
Q
-
N
-
P
Q
A
H
V
I
E
N
L
H
A
A
A
Y
--
R
N
A
L
A
N
S
L
Y
C
P
D
Y
R
I
G
K
------
V
----
T
P
---
V
E
L
H
D
Y
V
Q
N
H
F
T
S
----
A
R
M
A
L
I
G
-
L
G
V
S
H
P
---
V
L
K
Q
V
---
A
-
E
Q
-
F
L
N
I
R
G
G
------
L
G
-
L
--
S
--
G
------
A
---
K
----
A
----
K
-
Y
-
H
--
G
G
---
E
I
R
-
E
Q
N
------
G
-
D
S
L
V
H
A
A
L
V
A
-
E
S
A
--
A
I
---
G
S
A
E
A
N
A
F
S
V
L
Q
-
H
V
L
G
A
-------
G
PHVKRGSNA-------
T
S
S
L
-----
Y
Q
A
V
A
K
G
V
H
Q
P
F
D
-
V
S
A
F
N
A
--
S
----
Y
SD--
S
G
L
F
G
F
Y
T
--
I
S
Q
A
---
A
---
S
A
---
G
D
V
I
K
A
A
Y
N
Q
V
K
T
-
I
A
--
Q
G
N
L
---
S
N
P
D
V
Q
A
A
K
N
K
L
K
A
G
Y
L
M
-
S
--
V
-
E
S
--
S
--
E
G
F
L
D
--
E
V
-----------
G
S
Q
A
L
-
A
A
G
-
S
-
Y
--
T
-
P
P
S
T
V
L
Q
Q
I
D
A
V
A
--------
D
A
D
V
I
N
A
A
K
K
F
V
S
G
-
R
-
K
--
S
--
M
A
A
S
G
N
LGHTPFIDEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
54.63
14%
-79
- C3 -
2G47
2
IDE_HUMAN
A:
[16-987]
-PAIK
R
I
G
N
H
ITKSPEDK
R
E
Y
R
G
L
E
L
A
N
G
I
K
V
L
L
I
S
D
P
T
T
D
--
K
S
S
A
A
L
D
V
H
I
G
S
L
S
---
D
---
P
-
P
N
I
A
G
L
S
H
F
C
Q
H
M
L
F
L
G
T
K
K
---
Y
P
K
E
N
E
Y
S
Q
F
L
S
E
-
H
--------
A
G
S
S
N
A
F
T
S
G
E
H
T
N
Y
Y
F
D
V
S
-------------
H
E
H
L
E
G
A
L
D
R
F
A
Q
F
F
L
C
P
L
F
D
----------
E
S
-----------------
C
K
D
R
E
-
V
N
A
V
D
S
E
H
E
K
--
N
V
-
M
-
N
-
D
A
W
R
L
F
Q
L
E
K
A
T
G
N
P
-
K
H
P
F
S
K
F
G
T
G
N
K
Y
T
L
E
T
------
R
----
P
N
Q
E
G
I
D
V
R
Q
E
L
L
K
F
H
S
A
YYSS
N
L
M
A
V
C
V
L
G
R
E
S
L
D
---
D
L
T
N
L
---
V
-
V
K
-
L
---
F
S
E
V
E
N
K
N
-
V
P
-
L
--
P
--
E
------
F
---
P
----
E
HPFQ
E
-
E
-
H
--
L
K
---
Q
L
Y
-
K
I
V
P
-----
I
-
K
D
I
R
N
L
Y
V
T
F
-
P
I
P
-
D
L
Q
---
K
Y
Y
K
S
N
P
G
H
Y
L
G
-
H
L
I
G
H
-------
E
-----------
G
----
P
G
S
L
-----
L
S
E
L
K
S
K
-
G
W
V
N
T
-
L
V
G
G
Q
K
--
E
----
G
ARG-
F
M
F
F
I
I
N
V
--
D
L
T
E
---
E
---
G
L
---
L
H
V
E
D
I
I
L
H
M
F
Q
Y
-
I
Q
--
K
L
R
A
E
GP
Q
E
W
V
F
Q
E
C
K
D
L
N
A
V
A
F
R
F
-
K
--
D
K
E
R
--
P
--
R
G
Y
T
S
--
K
I
-----------
A
G
I
L
H
-
Y
-
Y
-
P
-
L
--
E
-
E
V
L
T
A
E
Y
L
L
E
E
F
R
--------
P
D
L
I
E
M
V
L
D
K
-
L
R
P
-
E
-
N
--
V
--
R
V
A
I
V
S
KSFEGKTDRTEEWYG
T
Q
Y
K
Q
E
A
IP
D
E
V
I
K
K
W
Q
N
ADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAM
S
K
L
W
F
K
Q
DDKFFLP
K
A
C
L
N
F
E
F
F
S
PFAYVD
P
L
H
C
N
M
A
Y
L
Y
L
E
L
L
K
D
S
L
N
E
Y
A
Y
A
A
E
L
A
G
L
S
Y
D
L
Q
N
T
IY
G
M
Y
L
S
V
K
G
YNDK
Q
P
I
L
L
K
K
I
I
E
K
M
A
T
F
E
I
D
E
K
R
F
E
I
I
K
E
A
Y
M
R
S
L
N
N
FRAEQ
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
TE
V
A
W
T
K
D
E
L
K
E
A
L
D
D
VT
L
P
R
L
K
A
F
I
P
Q
L
L
S
R
L
H
I
E
A
L
L
H
G
NIT
K
Q
A
A
L
G
I
M
Q
M
V
E
D
T
L
I
E
H
AH
T
K
P
L
L
PSQL
V
R
Y
R
E
VQLPDR
G
W
F
V
Y
Q
Q
R
N
EVHN
N
C
G
I
E
I
Y
YQTDMQS
T
S
E
N
M
F
L
E
L
F
C
Q
I
I
S
E
P
C
F
N
T
LRTKEQLGY
I
V
F
S
G
P
R
R
A
NGI
Q
G
L
R
F
I
I
Q
S
EKP
P
H
Y
L
E
S
R
V
E
A
F
L
I
T
M
E
K
S
I
E
D
MT
E
E
A
F
Q
K
H
I
Q
A
L
A
I
R
R
L
DKPKK
L
S
A
E
C
A
K
Y
W
G
E
I
I
S
QQYNFD
R
D
N
T
E
V
A
Y
L
K
T
LT
K
E
D
I
I
K
F
Y
K
E
MLAVDAPR
R
H
K
V
S
V
H
V
L
A
REMDSCPVVGNLSQAPAL
P
Q
P
E
V
I
QN
M
T
E
F
K
R
G
L
P
L
F
P
L
VKPH
I
N
F
M
A
41
HHSearch
53.09
12%
-70
- C3 -
3CWW
2
IDE_HUMAN
A:
[524-917]
-------------------------
D
T
A
M
S
K
L
W
F
K
Q
D
D
K
F
F
LP
K
A
N
L
N
F
E
F
F
-
S
P
F
A
YVD
P
---
L
-
H
S
N
M
--
A
Y
L
Y
L
E
L
L
K
D
S
L
N
E
---
Y
----
A
Y
A
A
E
---
L
A
--------
G
L
S
Y
D
L
Q
N
T
I
Y
----
G
M
Y
L
S
V
K
G
Y
N
-
D
--------
K
Q
P
I
L
L
K
K
I
I
E
K
M
A
T
F
-----
E
-----
I
D
E
A
-----------------
R
F
E
I
I
-
K
E
A
Y
M
R
S
L
N
N
--
F
R
-
A
E
Q
-
P
H
Q
H
A
M
Y
Y
L
R
L
L
M
T
--
E
V
A
W
T
K
--
D
E
L
K
E
A
L
A
D
------
V
----
T
L
---
P
R
L
K
A
F
I
P
Q
L
L
S
R
----
L
H
I
E
A
L
L
H
G
N
I
T
K
Q
---
A
A
L
G
I
M
Q
M
V
E
D
T
-
L
---
I
E
H
A
H
T
K
P
-
L
L
-
P
--
S
--
Q
L
A
A
Y
R
E
V
---
Q
----
L
----
P
-
D
-
R
--
G
W
---
F
V
Y
Q
Q
R
N
E
-----
V
-
H
N
N
S
G
I
E
I
Y
Y
-
Q
T
D
-
M
-
Q
---
S
T
S
E
N
M
F
L
E
L
F
A
-
Q
I
I
--------------------------
S
E
P
A
-----
F
N
T
L
R
T
K
E
Q
L
G
Y
I
-
V
F
S
G
P
R
--
R
----
A
NGI
Q
G
L
R
F
I
I
Q
S
--
E
K
P
P
---
H
---
Y
L
---
E
S
R
V
E
A
F
L
I
T
M
E
K
-
S
I
---
E
D
M
---
T
E
E
A
F
Q
K
H
I
Q
A
L
A
I
R
R
L
D
-
K
--
P
-
K
K
--
L
--
S
A
E
S
A
--
K
Y
-----------
W
G
E
I
I
-
S
-
Q
-
Q
-
Y
NF
D
-
R
D
N
T
E
V
A
Y
L
K
T
L
T
--------
K
A
D
I
I
K
F
Y
K
E
-
M
L
A
-
V
-
D
--
A
--
P
R
R
H
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
51.74
9%
-73
- C3 -
1Q2L
6
PTRA_ECOLI
A:
[1-937]
ETGWQPIQETIRKSDKDN
R
Q
Y
Q
A
I
R
L
D
N
G
M
V
V
L
L
V
S
D
P
Q
A
V
--
K
S
L
S
A
L
V
V
P
V
G
S
L
E
---
D
---
P
-
E
A
Y
Q
G
L
A
H
Y
L
E
H
M
S
L
M
G
S
K
K
---
Y
P
Q
A
D
S
L
A
E
Y
L
K
M
-
H
--------
G
G
S
H
N
A
S
T
A
P
Y
R
T
A
F
Y
L
E
V
-------------
E
N
D
A
L
P
G
A
V
D
R
L
A
D
A
I
A
E
P
L
L
D
K
K
Y
---------------------------
A
E
R
E
-
R
N
A
V
N
A
E
L
T
M
--
A
R
-
T
-
R
-
D
G
M
R
M
A
Q
V
S
A
E
T
I
N
P
-
A
H
P
G
S
K
F
S
G
G
N
L
E
T
L
S
D
------
K
----
P
G
---
N
P
V
Q
Q
A
L
K
D
F
H
E
K
YYSA
N
L
M
K
A
V
I
Y
S
N
K
P
L
P
---
E
L
A
K
M
---
A
-
A
D
-
T
---
F
G
R
V
P
N
K
E
-
S
K
-
K
--
P
--
E
------
I
---
T
VPVV
T
----
D
-
A
-
Q
--
K
G
---
I
I
I
-
H
Y
V
P
-----
A
-
L
P
R
K
V
L
R
V
E
F
-
R
I
D
--
N
N
---
S
A
K
F
R
S
K
T
D
E
L
I
-
T
Y
L
I
G
-------
N
-----------
R
----
S
P
G
T
-----
L
S
D
W
L
Q
K
Q
G
L
V
E
G
-
I
S
A
N
S
D
--
P
----
I
VNGN
S
G
V
L
A
I
S
A
--
S
L
T
D
---
K
---
G
L
A
N
R
D
Q
V
V
A
A
I
F
S
Y
L
N
L
-
L
R
--
E
K
G
I
---
D
K
Q
Y
F
D
E
L
A
N
V
L
D
I
D
F
R
Y
-
P
--
S
-
I
T
--
R
D
-
M
D
Y
V
E
--
W
L
-----------
A
D
T
M
I
-
R
-
V
-
P
-
V
--
E
-
H
T
L
D
A
V
N
I
A
D
R
Y
D
--------
A
K
A
V
K
E
R
L
A
M
-
M
T
P
-
Q
-
N
--
A
--
R
I
W
Y
I
S
PKEPHNKTAYFVD
A
P
Y
Q
V
D
KIS
A
Q
T
F
A
D
W
Q
K
K
A
A
D
I
A
L
S
L
P
ELNPYIPDDF
S
L
I
K
S
EKKYDHPELIVDESN
L
R
V
V
Y
A
P
S
RYFASEP
K
A
D
V
S
L
I
LRNPKAMDS
A
R
N
Q
V
M
F
A
L
N
D
Y
L
A
G
L
A
L
D
Q
L
S
N
Q
A
S
V
G
G
I
S
F
S
T
N
A
N
N
G
L
M
V
N
A
N
GYTQR
L
P
Q
L
F
Q
A
L
L
E
G
Y
F
S
Y
T
A
TE
D
Q
L
E
Q
A
K
S
W
Y
N
Q
M
M
D
S
A
E
KGK
A
F
E
Q
A
I
MPAQMLSQV
P
Y
F
S
R
D
E
R
R
K
I
LPSIT
L
K
E
V
L
A
Y
R
D
A
L
K
SG
A
R
P
E
F
M
V
I
G
NMT
E
A
Q
A
T
T
L
A
R
D
V
Q
K
Q
L
GADGS
E
W
C
R
N
K
D
V
V
VD
K
K
Q
S
V
I
F
E
K
A
G
NST
D
S
A
L
A
A
V
F
V
P
T
GYD
E
Y
T
S
S
A
Y
S
S
L
L
G
Q
I
V
Q
PWFYNQLRTEEQLGYA
V
F
A
F
P
M
S
V
GR
Q
W
G
M
G
F
L
L
Q
S
NDKQ
P
S
F
L
W
E
R
Y
K
A
F
F
P
T
A
E
A
K
L
R
A
MK
P
D
E
F
A
Q
I
Q
Q
A
V
I
T
Q
M
L
QAPQT
L
G
E
E
A
S
K
L
S
K
D
F
D
R
GNMRFD
S
R
D
K
I
V
A
Q
I
K
L
LT
P
Q
K
L
A
D
F
F
H
Q
A
VVEPQ
G
M
A
I
L
S
Q
I
SGSQNGKA
E
Y
V
H
P
E
G
W
K
V
W
EN
V
S
A
L
Q
Q
T
M
P
L
M
S
EK--------------------------
37
HHSearch
47.08
12%
-66
- C3 -
3CX5
-
QCR2_YEAST
B:
[1-320]
-----------------------------
L
T
V
S
-
A
R
D
A
P
T
K
--
I
S
T
L
A
V
K
V
H
-
G
G
S
R
---
Y
---
A
T
K
D
G
V
--
A
H
L
L
N
R
F
N
F
Q
N
T
N
T
---
R
S
-
A
L
K
L
V
R
E
S
E
L
L
---------
G
G
T
F
K
S
T
L
D
R
E
----
Y
I
T
L
K
A
T
F
L
K
-
D
--------
D
L
P
Y
Y
V
N
A
L
A
D
V
L
Y
K
T
-----
A
-----
F
K
P
H
-----------------
E
L
T
E
S
V
L
P
A
A
R
Y
D
Y
A
V
--
A
E
-
Q
-
C
-
P
V
K
S
A
E
D
Q
L
Y
A
I
T
F
R
--
K
G
L
G
N
P
L
L
Y
--
D
G
V
E
R
------
V
----
S
L
---
Q
D
I
K
D
F
A
D
K
V
Y
T
K
----
E
N
L
E
V
S
G
-
E
N
V
V
E
A
---
D
L
K
R
F
---
V
D
E
S
L
L
---
S
T
L
P
A
G
K
S
-
L
V
-
S
--
K
S
-
E
------
P
---
K
----
F
----
F
-
L
-
G
--
E
E
----
N
R
-
V
R
-
F
-----
I
--
G
D
S
V
A
A
I
G
I
-
P
V
N
-
K
-------
A
S
L
A
Q
Y
E
V
L
A
-
N
Y
L
T
S
--------------------------
A
L
---------
S
E
L
S
G
L
I
S
S
-
A
K
L
D
K
F
--
T
----
D
----
G
G
L
F
T
L
F
V
--
R
D
Q
--------
D
S
---
A
V
V
S
S
N
I
K
K
I
V
A
D
-
L
K
--
K
-------
G
K
D
L
S
P
A
I
N
Y
T
K
L
K
N
A
V
-
Q
--
N
-
E
S
--
V
--
S
S
P
I
E
--
L
N
-----------
F
D
A
V
K
-
D
-
F
-
K
-
L
--
G
-
K
F
N
Y
V
A
V
G
D
V
S
N
L
--------
P
Y
L
D
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------