@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03200: (2016-06-05 )
MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPTIRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGLDIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQAYLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYTAIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGEDWYGYFMRRLAERPSNIAFAFKGMTKK
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50.....-...60-...-......70........80...--------------....------.90-----..------.......100-----...-------..-------.----...110.......120.......130.......140..-----....-----.150---.--........160.......170.------.------.------..------..180.......190---------..----------....-----------...200.......210..--..--...---------------220.......230.......240.......250.......260..--.--...--.270...--.--...280.......290.......300.---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------MIT
R
D
F
F
L
F
LSKS
G
F
L
N
K
M
A
R
N
WGSRVAA
G
K
I
IGGNDFNSSI
P
T
I
R
Q
LNSQG
L
S
V
T
-
V
D
H
L
--
G
E
F
-
V
N
S
A
E
V
A
R
E
R
T
E
E
C
I
Q
T
I
A
T
I
--------------
A
D
Q
E
------
L
N------S
H
------
V
S
L
K
M
T
SL-------GLD-------
I
D
-------
M
----
D
L
V
Y
E
N
M
T
K
I
L
Q
T
A
EK
H
K
I
M
V
T
I
DMEDE
V
R
C
Q
K
T
L
D
I
F
-----
K
D
F
R
-----
K
K
-----
Y
--
E
H
V
S
T
V
L
Q
A
Y
L
Y
RTEKDI
D
D
L
D
------
S
------
L
------
N
P
------
F
L
R
L
V
K
G
A
YKESE-----------KV----------AFPE-----------KSD
V
D
E
N
Y
K
K
I
I
R
K
Q
L
LN--GH--
Y
T
A
---------------
I
ATHD
D
K
M
I
D
F
T
K
Q
L
A
K
EHGIAND
K
F
E
F
Q
M
L
YGMRS
Q
T
Q
L
S
L
V
KE--G--Y
N
M
--
R
V
Y
L
PYG--E--
D
W
Y
G
Y
F
M
R
R
L
AERPS
N
I
A
F
A
FKGMTKK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.05
26%
0
- C- -
4NMF
6
?
A:
[117-441]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
-
V
D
V
L
--
G
E
A
-
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLPGKG
G
D
P
G
------
L
D
WGHAPK
V
N
------
I
A
V
K
P
T
A
L
F
CLANPQ
D
F
E
-------
G
S
-------
V
----
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
-----
R
R
L
K
L
E
Y
--
R
D
-----
Y
--
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
------
A
W
A
K
E
H
K
V
------
Q
I
------
S
V
R
L
V
K
G
A
Y
W
D
Y
E
-----------
T
V
K
A
K
Q
N
DWEVP
V
W
T
I
-----------
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
F
A
---------------
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
A
E
P
V
R
K
G
I
L
K
V
--
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.79
42%
-100
- C2 -
4H6Q
3
?
A:
[33-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
-
L
D
L
L
--
G
E
F
-
I
D
S
P
A
K
C
T
E
F
A
D
D
V
I
K
L
I
E
A
A
--------------
H
A
A
G
------
I
K
------
P
Y
------
V
S
I
K
L
S
S
V
-------
G
Q
G
-------
K
D
-------
E
NGE-
D
L
G
L
T
N
A
R
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
-----
R
T
L
V
-----
G
E
-----
F
GA
E
H
V
G
T
V
L
Q
S
Y
L
Y
R
S
L
G
D
R
A
S
L
D
------
D
------
L
------
R
P
------
N
I
R
M
V
K
G
A
Y
L
E
P
A
-----------
T
V
----------
A
Y
P
D
-----------
K
A
D
V
D
Q
N
Y
R
R
L
V
F
Q
H
L
K
A
--
G
N
--
Y
T
N
---------------
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
E
--
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
W
Y
A
Y
F
S
R
R
I
A
E
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
75.72
42%
-98
- C2 -
4H6R
2
?
C:
[33-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
-
L
D
L
L
--
G
E
F
-
I
D
S
P
A
K
C
T
E
F
A
D
D
V
I
K
L
I
E
A
A
--------------
H
A
A
G
------
I
K
------
P
Y
------
V
S
I
K
L
S
S
V
-------
G
Q
G
-------
K
D
-------
E
NGE-
D
L
G
L
T
N
A
R
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
-----
R
T
L
V
-----
G
E
-----
F
GA
E
H
V
G
T
V
L
Q
S
Y
L
Y
R
S
L
G
D
R
A
S
L
D
------
D
------
L
------
R
P
------
N
I
R
M
V
K
G
A
Y
L
E
P
A
-----------
T
V
----------
A
Y
P
D
-----------
K
A
D
V
D
Q
N
Y
R
R
L
V
F
Q
H
L
K
A
--
G
N
--
Y
T
N
---------------
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
E
--
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
W
Y
A
Y
F
S
R
R
I
A
E
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.28
42%
-103
- C2 -
4H6Q
2
?
C:
[33-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
-
L
D
L
L
--
G
E
F
-
I
D
S
P
A
K
C
T
E
F
A
D
D
V
I
K
L
I
E
A
A
--------------
H
A
A
G
------
I
K
------
P
Y
------
V
S
I
K
L
S
S
V
-------
G
Q
G
-------
K
D
-------
E
NGE-
D
L
G
L
T
N
A
R
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
-----
R
T
L
V
-----
G
E
-----
F
GA
E
H
V
G
T
V
L
Q
S
Y
L
Y
R
S
L
G
D
R
A
S
L
D
------
D
------
L
------
R
P
------
N
I
R
M
V
K
G
A
Y
L
E
P
A
-----------
T
V
----------
A
Y
P
D
-----------
K
A
D
V
D
Q
N
Y
R
R
L
V
F
Q
H
L
K
A
--
G
N
--
Y
T
N
---------------
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
E
--
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
W
Y
A
Y
F
S
R
R
I
A
E
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
75.20
41%
-101
- C2 -
4H6Q
3
?
A:
[19-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
E
Q
L
A
R
Q
K
-
M
W
N
L
A
E
R
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
-
L
D
L
L
--
G
E
F
-
I
D
S
P
A
K
C
T
E
F
A
D
D
V
I
K
L
I
E
A
A
--------------
H
A
A
G
------
I
K
------
P
Y
------
V
S
I
K
L
S
S
V
-------
G
Q
G
-------
K
D
ENG----
E
----
D
L
G
L
T
N
A
R
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
-----
R
T
L
V
-----
G
E
-----
F
GA
E
H
V
G
T
V
L
Q
S
Y
L
Y
R
S
L
G
D
R
A
S
L
D
------
D
------
L
------
R
P
------
N
I
R
M
V
K
G
A
Y
L
E
P
A
-----------
T
V
----------
A
Y
P
D
-----------
K
A
D
V
D
Q
N
Y
R
R
L
V
F
Q
H
L
K
A
--
G
N
--
Y
T
N
---------------
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
E
--
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
W
Y
A
Y
F
S
R
R
I
A
E
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.91
42%
-99
- C2 -
4H6R
1
?
A:
[33-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
R
F
V
A
G
E
S
I
E
S
A
I
Q
A
V
Q
A
L
E
R
D
G
I
A
G
N
-
L
D
L
L
--
G
E
F
-
I
D
S
P
A
K
C
T
E
F
A
D
D
V
I
K
L
I
E
A
A
--------------
H
A
A
G
------
I
K
------
P
Y
------
V
S
I
K
L
S
S
V
-------
G
Q
G
-------
K
D
-------
E
NGE-
D
L
G
L
T
N
A
R
R
I
I
A
K
A
K
E
Y
G
G
F
I
C
L
D
M
E
D
H
T
R
V
D
V
T
L
E
Q
F
-----
R
T
L
V
-----
G
E
-----
F
GA
E
H
V
G
T
V
L
Q
S
Y
L
Y
R
S
L
G
D
R
A
S
L
D
------
D
------
L
------
R
P
------
N
I
R
M
V
K
G
A
Y
L
E
P
A
-----------
T
V
----------
A
Y
P
D
-----------
K
A
D
V
D
Q
N
Y
R
R
L
V
F
Q
H
L
K
A
--
G
N
--
Y
T
N
---------------
V
A
T
H
D
E
R
I
I
D
D
V
K
R
F
V
L
A
H
G
I
G
K
D
A
F
E
F
Q
M
L
Y
G
I
R
R
D
L
Q
K
Q
L
A
A
E
--
G
--
Y
R
V
--
R
V
Y
L
P
Y
G
--
R
--
D
W
Y
A
Y
F
S
R
R
I
A
E
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.89
40%
-114
- C2 -
2G37
3
?
A:
[54-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
V
A
G
E
T
L
E
E
A
L
K
A
A
E
A
L
E
R
E
G
V
H
A
I
-
L
D
L
L
--
G
E
M
-
V
R
T
E
E
E
A
R
A
F
Q
R
G
L
L
E
L
V
W
A
L
--------------
A
G
K
P
------
W
P
------
K
Y
------
I
S
L
K
L
T
Q
L
-------
G
L
D
-------
L
S
-------
E
----
D
L
A
L
A
L
L
R
E
V
L
R
E
A
E
P
R
G
V
F
V
R
L
D
M
E
D
S
P
R
V
E
A
T
L
R
L
Y
-----
R
A
L
R
-----
E
E
G----
F
--
S
Q
V
G
I
V
L
Q
S
Y
L
Y
R
T
E
K
D
L
L
D
L
L
------
P
------
Y
------
R
P
------
N
L
R
L
V
K
G
A
Y
R
E
P
K
-----------
E
V
----------
A
F
P
D
-----------
K
R
L
I
D
A
E
Y
L
H
L
G
K
L
A
L
K
E
--
G
L
--
Y
V
A
---------------
F
A
T
H
D
P
R
I
I
A
E
L
K
R
Y
T
E
A
M
G
I
P
R
S
R
F
E
F
Q
F
L
Y
G
V
R
P
E
E
Q
R
R
L
A
R
E
--
G
--
Y
T
V
--
R
A
Y
V
P
Y
G
--
R
--
D
W
Y
P
Y
L
T
R
R
I
A
E
R
P
E
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.82
40%
-114
- C2 -
2G37
3
?
B:
[54-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
V
A
G
E
T
L
E
E
A
L
K
A
A
E
A
L
E
R
E
G
V
H
A
I
-
L
D
L
L
--
G
E
M
-
V
R
T
E
E
E
A
R
A
F
Q
R
G
L
L
E
L
V
W
A
L
--------------
A
G
K
P
------
W
P
------
K
Y
------
I
S
L
K
L
T
Q
L
-------
G
L
D
-------
L
S
-------
E
----
D
L
A
L
A
L
L
R
E
V
L
R
E
A
E
P
R
G
V
F
V
R
L
D
M
E
D
S
P
R
V
E
A
T
L
R
L
Y
-----
R
A
L
R
-----
E
E
G----
F
--
S
Q
V
G
I
V
L
Q
S
Y
L
Y
R
T
E
K
D
L
L
D
L
L
------
P
------
Y
------
R
P
------
N
L
R
L
V
K
G
A
Y
R
E
P
K
-----------
E
V
----------
A
F
P
D
-----------
K
R
L
I
D
A
E
Y
L
H
L
G
K
L
A
L
K
E
--
G
L
--
Y
V
A
---------------
F
A
T
H
D
P
R
I
I
A
E
L
K
R
Y
T
E
A
M
G
I
P
R
S
R
F
E
F
Q
F
L
Y
G
V
R
P
E
E
Q
R
R
L
A
R
E
--
G
--
Y
T
V
--
R
A
Y
V
P
Y
G
--
R
--
D
W
Y
P
Y
L
T
R
R
I
A
E
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.59
26%
-114
- C2 -
4NME
4
?
A:
[117-441]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
-
V
D
V
L
--
G
E
A
-
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLPGKG
G
D
P
G
------
L
D
WGHAPK
V
N
------
I
A
V
K
P
T
A
L
F
CLANPQ
D
F
E
-------
G
S
-------
V
----
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
-----
R
R
L
K
L
E
Y
--
R
D
-----
Y
--
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
------
A
W
A
K
E
H
K
V
------
Q
I
------
S
V
R
L
V
K
G
A
Y
W
D
Y
E
-----------
T
V
K
A
K
Q
N
DWEVP
V
W
T
I
-----------
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
F
A
---------------
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
---
V
R
K
G
I
L
K
V
--
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.28
26%
-106
- C2 -
4NMB
2
?
A:
[117-443]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
-
V
D
V
L
--
G
E
A
-
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLPGKG
G
D
P
G
------
L
D
WGHAPK
V
N
------
I
A
V
K
P
T
A
L
F
CLANPQ
D
F
E
-------
G
S
-------
V
----
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
-----
R
R
L
K
L
E
Y
--
R
D
-----
Y
--
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
------
A
W
A
K
E
H
K
V
------
Q
I
------
S
V
R
L
V
K
G
A
Y
W
D
Y
E
-----------
T
V
K
A
K
Q
N
DWEVP
V
W
T
I
-----------
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
F
A
---------------
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
A
E
P
V
R
K
G
I
L
K
V
--
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
MV
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.08
26%
-115
- C2 -
4NMD
4
?
A:
[117-439]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
-
V
D
V
L
--
G
E
A
-
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLPGKG
G
D
P
G
------
L
D
WGHAPK
V
N
------
I
A
V
K
P
T
A
L
F
CLANPQ
D
F
E
-------
G
S
-------
V
----
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
-----
R
R
L
K
L
E
Y
--
R
D
-----
Y
--
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
------
A
W
A
K
E
H
K
V
------
Q
I
------
S
V
R
L
V
K
G
A
Y
W
D
Y
E
-----------
T
V
K
A
K
Q
N
DWEVP
V
W
T
I
-----------
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
F
A
---------------
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
A
E
P
V
R
K
G
I
L
K
V
--
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.90
26%
-107
- C2 -
4NM9
5
?
A:
[117-439]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
-
V
D
V
L
--
G
E
A
-
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLPGKG
G
D
P
G
------
L
D
WGHAPK
V
N
------
I
A
V
K
P
T
A
L
F
CLANPQ
D
F
E
-------
G
S
-------
V
----
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
-----
R
R
L
K
L
E
Y
--
R
D
-----
Y
--
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
------
A
W
A
K
E
H
K
V
------
Q
I
------
S
V
R
L
V
K
G
A
Y
W
D
Y
E
-----------
T
V
K
A
K
Q
N
DWEVP
V
W
T
I
-----------
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
F
A
---------------
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
A
E
P
V
R
K
G
I
L
K
V
--
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.82
26%
-108
- C2 -
4NMA
7
?
A:
[117-441]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
K
N
L
E
K
L
R
K
D
G
F
A
A
V
-
V
D
V
L
--
G
E
A
-
T
L
S
E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
QGSWKGLPGKG
G
D
P
G
------
L
D
WGHAPK
V
N
------
I
A
V
K
P
T
A
L
F
CLANPQ
D
F
E
-------
G
S
-------
V
----
V
A
I
L
D
R
M
R
R
I
F
K
K
V
M
E
L
N
G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
-----
R
R
L
K
L
E
Y
--
R
D
-----
Y
--
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
------
A
W
A
K
E
H
K
V
------
Q
I
------
S
V
R
L
V
K
G
A
Y
W
D
Y
E
-----------
T
V
K
A
K
Q
N
DWEVP
V
W
T
I
-----------
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
--
H
Q
I
C
H
F
A
---------------
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
A
E
P
V
R
K
G
I
L
K
V
--
A
--
G
R
I
--
R
L
Y
A
P
Y
G
--
N
MV
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
62.44
28%
-90
- C2 -
4Q71
7
?
A:
[3-990]
MPNIPPPFTAPYAPD
D
A
E
I
A
A
R
L
L
P
A
S
HLS
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
KRLGG
V
E
D
M
L
R
E
F
ALS
T
K
E
G
L
A
L
M
V
L
A
E
A
L
L
R
VPD
A
R
T
A
D
Q
F
I
E
DKLGEGD
F
I
H
H
E
T
K
S
T
A
F
L
V
NASAWAR
V
I
Q
P
GETPDG
T
I
G
R
L
V
K
R
LG
A
P
A
V
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
G
Q
K
T
R
Y
----------------------------
S
-
F
D
M
L
--
G
E
G
-
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
--------------
G
K
A
A
------
G
N
------
H
A
LPD
R
P
G
I
S
V
K
L
S
A
L
H
PRFEAI
S
R
A
-------
R
V
-------
M
----
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
-----
A
A
T
L
A
DPSL
K
G
-----
W
--
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
------
A
------
L
------
A
R
A
H
D
R
K
L
M
V
R
L
V
K
G
A
Y
W
D
T
E
-----------
I
K
----------
R
A
Q
E
R
GLDGYPVFTR
K
A
M
T
D
L
N
Y
V
A
C
A
S
K
L
L
A
L
--
R
P
R
I
F
P
Q
---------------
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
----
G
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
H
A
D
--
I
A
Y
--
R
T
Y
A
P
V
G
S
H
R
--
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
A
Q
A
A
D
Y
R
VP
V
P
A
L
L
QR
P
A
D
A
I
VRPQAAAHPRIPLPCDLFAPE
R
R
N
S
R
G
V
E
FGA
R
T
A
L
D
Q
L
L
T
D
V
K
A
EI
A
D
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
F
A
G
W
S
R
TP
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
E
S
R
S
A
H
F
I
A
L
L
Q
R
EGGKT
L
D
D
A
L
S
E
L
R
E
A
A
D
F
C
R
Y
Y
A
A
Q
G
R
K
L
FG
S
E
T
A
M
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
I
S
P
WNFPL
A
I
F
L
G
Q
V
T
A
A
L
M
A
G
N
S
V
V
A
K
P
A
EQT
P
R
I
A
R
E
A
V
A
L
L
H
E
A
GIPKSA
L
Y
L
V
T
G
D
G
R
I
G
A
A
L
T
A
HPDIA
G
V
V
F
T
G
S
T
E
V
A
R
S
I
N
R
A
L
A
A
KDGPI
V
P
L
I
A
E
T
G
G
I
N
A
M
I
A
D
ATAL
P
E
Q
V
A
D
W
V
V
T
S
A
FRSAGQRCSALR
L
L
F
V
Q
EDV
A
D
R
M
I
E
M
V
A
G
A
A
R
E
LKIGDPSDVATHVGPVID
V
E
A
K
Q
R
L
D
A
H
I
A
R
M
K
T
E
ARLH
F
A
G
P
A
P
EGCFV
A
P
H
I
F
E
L
TEAGQLTEEVFGP
I
L
H
V
V
R
Y
R
PEN
L
E
R
V
L
R
A
I
E
R
T
GYGL
T
L
G
V
H
S
RI
D
D
S
I
E
A
I
I
D
R
VQVG
N
I
Y
V
NRNMIGAVVGVQP
F
G
G
N
GLSGTGPKAGGPH
Y
L
A
R
F
A
T
E
Q
T
V
T
I
NTAAA
39
HHSearch
52.81
26%
-80
- C2 -
3HAZ
7
?
A:
[151-472]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
A
V
R
T
A
T
-
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
R
S
G
Q
K
T
R
Y
S
-
F
D
M
L
--
G
E
G
-
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
--------------
G
K
A
A
GNHALP
D
R
------
P
G
------
I
S
V
K
L
S
A
L
-------
H
P
R
-------
F
E
AIS----
R
A
R
V
M
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
-----
A
A
T
L
-----
A
D
PSLKG
W
--
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
A
L
A
R
A
H
D
------
R
------
K
L
------
M
V
R
L
V
K
G
A
Y
W
D
T
E
I
K
R
A
Q
E
R
GLDG
Y
P
----------
V
F
T
R
-----------
K
A
M
T
D
L
N
Y
V
A
C
A
S
K
L
L
A
L
RP
R
I
--
F
P
Q
---------------
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
G
----
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
--
H
AD
I
A
Y
--
R
T
Y
A
P
V
G
--
S
HR
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
49.45
23%
-81
- C2 -
3HAZ
7
?
A:
[155-469]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
R
S
G
Q
K
T
R
Y
S
-
F
D
M
L
--
G
E
G
-
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
--------------
G
K
A
A
------
G
N
------
H
A
LPD
R
P
G
I
S
V
K
L
S
A
L
-------
H
P
R
-------
F
E
AIS
R
A
R
V
M
----
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
-----
K
G
-----
W
--
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
------
A
------
L
A
R
A
H
D
R
K
L
------
M
V
R
L
V
K
G
A
Y
W
D
T
E
------------
I
----------
K
R
A
Q
-----------
E
R
G
L
D
-
G
Y
P
V
F
T
R
K
A
M
T
D
--
L
N
--
Y
V
A
C
A
S
K
L
L
A
L
RPR
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
----
G
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
--
H
--
A
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
--
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
49.17
23%
-82
- C2 -
4Q73
4
?
A:
[155-475]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
--
G
Q
K
T
R
Y
S
-
F
D
M
L
--
G
E
G
-
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
--------------
G
K
A
A
------
G
N
------
H
A
LPD
R
P
G
I
S
V
K
L
S
A
L
-------
H
P
R
-------
F
E
AIS
R
A
R
V
M
----
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
-----
K
G
-----
W
--
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
------
A
------
L
A
R
A
H
D
R
K
L
------
M
V
R
L
V
K
G
A
Y
W
D
T
E
------------
I
----------
K
R
A
Q
-----------
E
R
G
L
D
-
G
Y
P
V
F
T
R
K
A
M
T
D
--
L
N
--
Y
V
A
C
A
S
K
L
L
A
L
RPR
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
----
G
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
--
H
--
A
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
--
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.10
23%
-82
- C2 -
4Q72
4
?
A:
[155-475]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
--
G
Q
K
T
R
Y
S
-
F
D
M
L
--
G
E
G
-
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
--------------
G
K
A
A
------
G
N
------
H
A
LPD
R
P
G
I
S
V
K
L
S
A
L
-------
H
P
R
-------
F
E
AIS
R
A
R
V
M
----
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
-----
K
G
-----
W
--
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
------
A
------
L
A
R
A
H
D
R
K
L
------
M
V
R
L
V
K
G
A
Y
W
D
T
E
------------
I
----------
K
R
A
Q
-----------
E
R
G
L
D
-
G
Y
P
V
F
T
R
K
A
M
T
D
--
L
N
--
Y
V
A
C
A
S
K
L
L
A
L
RPR
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
----
G
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
--
H
--
A
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
--
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
48.74
23%
-82
- C2 -
4Q71
5
?
A:
[155-475]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
Q
A
L
E
R
G
K
P
--
G
Q
K
T
R
Y
S
-
F
D
M
L
--
G
E
G
-
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
--------------
G
K
A
A
------
G
N
------
H
A
LPD
R
P
G
I
S
V
K
L
S
A
L
-------
H
P
R
-------
F
E
AIS
R
A
R
V
M
----
V
E
L
V
P
Q
L
L
D
L
A
Q
R
A
K
A
H
D
L
N
F
T
V
D
A
E
E
A
D
R
L
E
L
S
L
D
V
I
A
A
T
L
A
D
P
S
L
-----
K
G
-----
W
--
D
G
F
G
L
A
I
Q
A
Y
Q
K
R
A
S
A
V
I
D
Y
V
D
------
A
------
L
A
R
A
H
D
R
K
L
------
M
V
R
L
V
K
G
A
Y
W
D
T
E
------------
I
----------
K
R
A
Q
-----------
E
R
G
L
D
-
G
Y
P
V
F
T
R
K
A
M
T
D
--
L
N
--
Y
V
A
C
A
S
K
L
L
A
L
RPR
I
F
P
Q
F
A
T
H
N
A
L
T
V
A
T
V
L
E
M
A
E
----
G
S
S
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
--
H
--
A
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
--
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
33.53
16%
-191
- C2 -
3KWS
2
?
A:
[71-170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
N
G
R
N
I
K
V
S
A
I
C
A
G
FK
G
F
I
L
S
T
D
P
A
I
R
K
E
C
M
D
T
M
K
E
I
I
A
A
A
--------------
G
E
L
G
------
S
T
-------
G
------
V
I
I
V
P
A
F
N
-------
G
Q
V
PALPHT
M
E
T
-------
R
----
D
F
L
C
E
Q
F
N
E
M
G
T
F
A
A
Q
H
G
T
S
V
I
F
E
P
L
N
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------