@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu03660: (2016-06-06 )
MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQKYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMALEYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDIDKDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLADVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFRKWLDQ
Atome Classification :
(20 SA)
.........10........20--.....-..------.30----.----.----.---.....---40--..---.......50........60...-.....70........80.....--...90...-.....100.......110.......120-..--------......130---------........140.......150........160--........170.......180..-.....---190--------...-...------.200----.--------...--...210---------------..---.....220-........230.......240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MERAGICHSDGF
D
L
A
Y
R
IEGE--G
A
P
I
L
-
V
I------GSA----V----Y----Y---
P
R
L
F
S
---
S
---
D
I
---
K
QK
Y
Q
W
V
F
VDHRGFA
K
P
K
R
E
L
R-AE
D
S
R
L
D
A
V
L
A
D
I
E
R
M
R
T
F
L
QL--E
D
V
T
I
LGH-SG
H
A
F
M
A
L
E
Y
A
R
T
Y
P
K
Q
V
R
K
V
A
L
FNTA--PD--------
N
S
E
E
R
Q
R
K
----------
S
E
S
F
F
M
E
T
A
S
L
E
R
K
K
R
F
E
K
D
-
I
E
NL
P
Q
DID-K--
D
P
E
R
R
F
V
H
M
C
I
R
A
E
A
K
S
F
Y
Q
ERP-H
A
A
A
L
---
W
D
G
--------VFT-NM
P
------
I
I
D
E
----
L
--------WG
N
--
T
F
A
R
I
D
---------------
L
L
---
Q
R
L
A
DV-R-M
P
V
Y
I
GLG
R
Y
D
Y
L
VA
P
V
S
L
W
D
A
V
D
G
L
Y
P
H
V
D
K
V
I
F
EKSGHQPMLEE
P
E
A
F
D
Q
S
F
R
K
W
LDQ
6
PsiBlast_PDB
83.40
22%
-99
- C1 -
1X2E
1
PIP_SERMA
A:
[22-306]
--------
G
D
G
H
R
I
Y
W
E
L
S
G
N
PN
G
K
P
A
V
-
F
I
H
G
GPGG
G
I
S
----
P
----
H
----
H
---
R
Q
L
F
D
------------
P
E
R
Y
K
V
L
L
F
D
Q
R
G
C
G
R
S
R
P
H
A
S
-
L
D
N
N
T
T
W
H
L
V
A
D
I
E
R
L
R
E
M
A
G
V
--
E
Q
W
L
V
F
G
G
-
S
W
G
S
T
L
A
L
A
Y
A
Q
T
H
P
E
R
V
S
E
M
V
L
R
G
I
F
--------------
T
L
R
K
Q
R
----------
L
H
W
Y
Y
Q
D
G
A
S
R
F
F
P
E
K
W
E
R
V
-
L
S
I
L
S
D
D
E
R
-
K
--
D
V
I
A
A
Y
R
Q
R
L
T
S
A
D
P
Q
-
V
Q
L
E
A
A
-
K
L
W
S
V
---
W
E
G
E
-------
T
V
T
-
L
L
P
SRE
S
A
S
F
G
E
D
----
D
--------
F
A
L
--
A
F
A
R
I
E
N
H
Y
F
T
H
L
GFLESDD
Q
L
L
---
R
N
V
P
L
I
-
R
H
I
P
A
V
I
V
H
G
R
Y
D
M
A
C
Q
V
Q
N
A
W
D
L
A
K
A
-
W
P
E
A
E
L
H
I
V
E
G
A
G
H
S
--
Y
D
E
P
G
I
L
H
Q
--------
5
PsiBlast_PDB
83.33
22%
-100
- C1 -
1X2B
1
PIP_SERMA
A:
[22-306]
--------
G
D
G
H
R
I
Y
W
E
L
S
G
N
PN
G
K
P
A
V
-
F
I
H
G
GPGG
G
I
S
----
P
----
H
----
H
---
R
Q
L
F
D
------------
P
E
R
Y
K
V
L
L
F
D
Q
R
G
C
G
R
S
R
P
H
A
S
-
L
D
N
N
T
T
W
H
L
V
A
D
I
E
R
L
R
E
M
A
G
V
--
E
Q
W
L
V
F
G
G
-
S
W
G
S
T
L
A
L
A
Y
A
Q
T
H
P
E
R
V
S
E
M
V
L
R
G
I
F
--------------
T
L
R
K
Q
R
----------
L
H
W
Y
Y
Q
D
G
A
S
R
F
F
P
E
K
W
E
R
V
-
L
S
I
L
S
D
D
E
R
-
K
--
D
V
I
A
A
Y
R
Q
R
L
T
S
A
D
P
Q
-
V
Q
L
E
A
A
-
K
L
W
S
V
---
W
E
G
E
-------
T
V
T
-
L
L
P
SRE
S
A
S
F
G
E
D
----
D
--------
F
A
L
--
A
F
A
R
I
E
N
H
Y
F
T
H
LGFLESDD
Q
L
L
---
R
N
V
P
L
I
-
R
H
I
P
A
V
I
V
H
G
R
Y
D
M
A
C
Q
V
Q
N
A
W
D
L
A
K
A
-
W
P
E
A
E
L
H
I
V
E
G
A
G
H
S
--
Y
D
E
P
G
I
L
H
Q
--------
4
PsiBlast_PDB
82.62
22%
-97
- C1 -
1WM1
1
PIP_SERMA
A:
[22-306]
--------
G
D
G
H
R
I
Y
W
E
L
S
G
N
PN
G
K
P
A
V
-
F
I
H
G
GPGG
G
I
S
----
P
----
H
----
H
---
R
Q
L
F
D
------------
P
E
R
Y
K
V
L
L
F
D
Q
R
G
C
G
R
S
R
P
H
A
S
-
L
D
N
N
T
T
W
H
L
V
A
D
I
E
R
L
R
E
M
A
G
V
--
E
Q
W
L
V
F
G
G
-
S
W
G
S
T
L
A
L
A
Y
A
Q
T
H
P
E
R
V
S
E
M
V
L
R
G
I
F
--------------
T
L
R
K
Q
R
----------
L
H
W
Y
Y
Q
D
G
A
S
R
F
F
P
E
K
W
E
R
V
-
L
S
I
L
S
D
D
E
R
-
K
--
D
V
I
A
A
Y
R
Q
R
L
T
S
A
D
P
Q
-
V
Q
L
E
A
A
-
K
L
W
S
V
---
W
E
G
E
-------
T
V
T
-
L
L
P
SR
E
S
A
S
F
G
E
D
----
D
--------
F
A
L
--
A
F
A
R
I
E
N
H
Y
F
T
H
L
GFLESDD
Q
L
L
---
R
N
V
P
L
I
-
R
H
I
P
A
V
I
V
H
G
R
Y
D
M
A
C
Q
V
Q
N
A
W
D
L
A
K
A
-
W
P
E
A
E
L
H
I
V
E
G
A
G
H
S
--
Y
D
E
P
G
I
L
H
Q
--------
3
PsiBlast_PDB
81.17
22%
-101
- C1 -
1QTR
-
PIP_SERMA
A:
[22-306]
--------
G
D
G
H
R
I
Y
W
E
L
S
G
N
PN
G
K
P
A
V
-
F
I
H
G
GPG
G
G
I
S
----
P
----
H
----
H
---
R
Q
L
F
D
------------
P
E
R
Y
K
V
L
L
F
D
Q
R
G
C
G
R
S
R
P
H
A
S
-
L
D
N
N
T
T
W
H
L
V
A
D
I
E
R
L
R
E
M
A
G
V
--
E
Q
W
L
V
F
G
G
-
S
W
G
S
T
L
A
L
A
Y
A
Q
T
H
P
E
R
V
S
E
M
V
L
R
G
I
F
--------------
T
L
R
K
Q
R
----------
L
H
W
Y
Y
Q
D
G
A
S
R
F
F
P
E
K
W
E
R
V
-
L
S
I
L
S
D
D
E
R
-
K
--
D
V
I
A
A
Y
R
Q
R
L
T
S
A
D
P
Q
-
V
Q
L
E
A
A
-
K
L
W
S
V
---
W
E
G
E
-------
T
V
T
-
L
L
P
SRESAS
F
G
E
D
----
D
--------
F
A
L
--
A
F
A
R
I
E
N
H
Y
F
T
H
L
GFLESDD
Q
L
L
---
R
N
V
P
L
I
-
R
H
I
P
A
V
I
V
H
G
R
Y
D
M
A
C
Q
V
Q
N
A
W
D
L
A
K
A
-
W
P
E
A
E
L
H
I
V
E
G
A
G
H
S
--
Y
D
E
P
G
I
L
H
Q
--------
9
PsiBlast_PDB
80.96
21%
-106
- C1 -
4UHE
4
?
A:
[16-268]
-----------
I
E
L
A
F
E
D
T
G
T
--
G
L
P
V
L
-
L
V
------
H
G
F
----
P
----
L
----
D
---
R
T
M
W
K
---
A
Q
R
E
E
L
---
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
--
S
Q
V
I
-
P
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
--
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
AR
P
D
--------
S
P
E
A
K
E
N
R
R
R
V
A
E
R
V
R
R
E
G
P
G
F
I
A
E
--
E
M
I
P
R
L
C
C
E
S
T
-
F
R
N
H
P
E
V
I
E
-
K
------------
I
R
Q
M
I
L
S
A
P
P
E
G
V
-
A
A
A
A
L
----------------------------------------------
G
--
M
A
E
R
P
D
---------------
S
T
---
D
L
L
P
A
L
-
S
-
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
-
E
A
M
A
R
T
I
P
Q
S
Q
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
8
PsiBlast_PDB
80.96
21%
-104
- C1 -
4UHD
6
?
A:
[16-268]
-----------
I
E
L
A
F
E
D
T
G
T
--
G
L
P
V
L
-
L
V
------
H
G
F
----
P
----
L
----
D
---
R
T
M
W
K
---
A
Q
R
E
E
L
---
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
--
S
Q
V
I
-
P
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
--
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
AR
P
D
--------
S
P
E
A
K
E
N
R
R
R
V
A
E
R
V
R
R
E
G
P
G
F
I
A
E
--
E
M
I
P
R
L
C
C
E
S
T
-
F
R
N
H
P
E
V
I
E
-
K
------------
I
R
Q
M
I
L
S
A
P
P
E
G
V
-
A
A
A
A
L
----------------------------------------------
G
--
M
A
E
R
P
D
---------------
S
T
---
D
L
L
P
A
L
-
S
-
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
-
E
A
M
A
R
T
I
P
Q
S
Q
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
11
PsiBlast_PDB
80.64
21%
-105
- C1 -
4UHH
3
?
A:
[16-268]
-----------
I
E
L
A
F
E
D
T
G
T
--
G
L
P
V
L
-
L
V
------
H
G
F
----
P
----
L
----
D
---
R
T
M
W
K
---
A
Q
R
E
E
L
---
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
--
S
Q
V
I
-
P
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
--
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
AR
P
D
--------
S
P
E
A
K
E
N
R
R
R
V
A
E
R
V
R
R
E
G
P
G
F
I
A
E
--
E
M
I
P
R
L
C
C
E
S
T
-
F
R
N
H
P
E
V
I
E
-
K
------------
I
R
Q
M
I
L
S
A
P
P
E
G
V
-
A
A
A
A
L
----------------------------------------------
G
--
M
A
E
R
P
D
---------------
S
T
---
D
L
L
P
A
L
-
S
-
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
-
E
A
M
A
R
T
I
P
Q
S
Q
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
20
PsiBlast_PDB
80.04
21%
-121
- C1 -
3E3A
1
BPOC_MYCTU
A:
[33-288]
-----------
I
N
L
A
Y
D
D
N
G
T
--
G
D
P
V
V
-
F
I
A
G
R---
G
G
A
GR--
T
----
W
----
H
---
P
H
Q
V
P
---
A
---
F
L
---
A
A
G
Y
R
C
I
T
F
D
N
R
G
I
G
A
T
E
N
----
A
E
G
F
T
T
Q
T
M
V
A
D
T
A
A
L
I
E
T
L
D
I
--
A
P
A
R
V
V
G
V
-
S
M
G
A
F
I
A
Q
E
L
M
V
V
A
P
E
L
V
S
S
A
V
L
M
A
T
---------------
R
G
R
L
D
R
----------
A
R
Q
F
F
N
K
A
----
E
A
E
L
Y
D
S
G
-
V
Q
L
P
P
T
----
Y
--
D
A
R
A
R
L
L
E
N
F
S
R
---
K
T
L
N
D
D
V
---
A
V
G
D
---
W
I
A
--------
M
F
S
-
M
W
P
------
I
K
S
T
P
G
L
R
C
--------
Q
L
D
--
C
A
P
Q
T
N
---------------
R
L
---
P
A
Y
R
N
I
-
A
-
A
P
V
L
V
-
I
G
F
A
D
D
V
V
T
P
P
Y
L
G
R
E
V
A
D
A
L
P
N
G
R
Y
L
Q
I
P
D
A
G
H
L
G
F
F
E
R
P
E
A
V
N
T
A
M
L
K
F
F
--
7
PsiBlast_PDB
79.87
21%
-107
- C1 -
4UHC
2
?
A:
[16-268]
-----------
I
E
L
A
F
E
D
T
G
T
--
G
L
P
V
L
-
L
V
------
H
G
F
----
P
----
L
----
D
---
R
T
M
W
K
---
A
Q
R
E
E
L
---
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
--
S
Q
V
I
-
P
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
--
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
AR
P
D
--------
S
P
E
A
K
E
N
R
R
R
V
A
E
R
V
R
R
E
G
P
G
F
I
A
E
--
E
M
I
P
R
L
C
C
E
S
T
-
F
R
N
H
P
E
V
I
E
-
K
------------
I
R
Q
M
I
L
S
A
P
P
E
G
V
-
A
A
A
A
L
----------------------------------------------
G
--
M
A
E
R
P
D
---------------
S
T
---
D
L
L
P
A
L
-
S
-
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
-
E
A
M
A
R
T
I
P
Q
S
Q
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
10
PsiBlast_PDB
78.82
21%
-106
- C1 -
4UHF
3
?
A:
[16-268]
-----------
I
E
L
A
F
E
D
T
G
T
--
G
L
P
V
L
-
L
V
------
H
G
F
----
P
----
L
----
D
---
R
T
M
W
K
---
A
Q
R
E
E
L
---
C
D
E
F
R
V
I
V
P
D
L
R
G
F
G
E
--
S
Q
V
I
-
P
G
V
A
T
M
E
A
M
A
D
D
L
A
G
L
C
N
H
L
G
L
--
T
G
K
I
V
L
G
G
L
S
M
G
G
Y
V
A
F
A
F
A
R
K
Y
R
D
R
L
A
G
L
I
L
C
D
T
R
AR
P
D
--------
S
P
E
A
K
E
N
R
R
R
V
A
E
R
V
R
R
E
G
P
G
F
I
A
E
--
E
M
I
P
R
L
C
C
E
S
T
-
F
R
N
H
P
E
V
I
E
-
K
------------
I
R
Q
M
I
L
S
A
P
P
E
G
V
-
A
A
A
A
L
----------------------------------------------
G
--
M
A
E
R
P
D
---------------
S
T
---
D
L
L
P
A
L
-
S
-
C
P
T
L
V
L
V
G
Q
F
D
A
I
S
P
P
E
E
M
-
E
A
M
A
R
T
I
P
Q
S
Q
F
V
V
I
P
D
A
G
H
L
P
P
M
E
Q
P
E
R
V
T
Q
A
I
R
E
W
L
--
14
PsiBlast_PDB
75.27
19%
-98
- C1 -
4IO0
2
?
A:
[26-304]
---------
N
G
V
N
L
H
Y
I
S
K
G
Q
--
G
E
L
M
L
-
F
L
------
H
G
F
----
P
----
D
----
F
---
S
H
I
W
R
---
H
---
Q
I
D
E
F
S
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
G
-
L
E
S
Y
E
I
D
V
L
V
E
D
I
R
Q
V
I
E
G
L
G
Y
--
S
S
C
T
L
V
V
H
-
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
A
F
N
G
P
--
H
P
--------
Y
T
A
M
R
E
L
R
----------
T
N
K
--
N
Q
Q
K
A
S
E
Y
M
K
W
F
Q
K
---
Q
E
V
Q
D
Y
M
E
-
R
--
D
N
F
S
G
L
R
K
L
V
I
D
P
G
V
K
K
G
Y
L
T
A
D
-
D
V
Q
A
Y
M
N
S
W
E
N
G
S
V
L
S
M
L
S
Y
Y
R
-
N
L
K
------
I
F
T
E
---------------
E
--
D
L
R
R
K
S
---------------
L
F
---
P
L
E
E
E
V
L
N
-
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
N
L
-
D
G
I
E
E
Y
V
P
N
I
S
V
H
R
L
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
N
K
34
HHSearch
74.92
20%
-82
- C1 -
3OOS
6
?
A:
[2-278]
M
W
T
T
N
I
I
K
T
P
R
G
K
F
E
Y
F
L
K
G
E
--
G
P
P
L
C
-
V
T
------
H
L
Y
----
S
E
Y
N
D
N
----
G
---
N
-
T
F
A
---
N
---
P
F
---
T
D
H
Y
S
V
Y
L
V
N
L
K
G
C
G
N
S
D
S
A
K
N
-
D
S
E
Y
S
M
T
E
T
I
K
D
L
E
A
I
R
E
A
L
Y
I
--
N
K
W
G
F
A
G
H
-
S
A
G
G
M
L
A
L
V
Y
A
T
E
A
Q
E
S
L
T
K
I
I
V
G
G
A
A
--
A
S
--------
K
E
Y
A
S
H
K
D
----------
S
-
I
Y
C
S
K
N
V
--
K
F
-
N
R
I
V
S
I
-
M
N
A
L
N
D
D
S
T
V
Q
--
E
E
R
K
A
L
S
R
E
W
A
L
M
---
S
F
Y
S
E
E
K
L
E
E
A
L
K
---
L
P
N
--------
S
G
K
-
T
V
G
------
N
R
L
N
----
Y
--------
F
R
Q
V-
E
Y
K
D
Y
D
---------------
V
R
---
Q
K
L
K
F
V
-
K
-
I
P
S
F
I
Y
C
G
K
H
D
V
Q
C
P
Y
I
-
F
S
C
E
I
A
N
L
I
P
N
A
T
L
T
K
F
E
E
S
N
H
N
P
F
V
E
E
I
D
K
F
N
Q
F
V
N
D
T
L
--
17
PsiBlast_PDB
73.62
19%
-94
- C1 -
4INZ
2
?
A:
[26-304]
---------
N
G
V
N
L
H
Y
I
S
K
G
Q
--
G
E
L
M
L
-
F
L
------
H
G
F
----
P
----
D
----
F
---
S
H
I
W
R
---
H
---
Q
I
D
E
F
S
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
G
-
L
E
S
Y
E
I
D
V
L
V
E
D
I
R
Q
V
I
E
G
L
G
Y
--
S
S
C
T
L
V
V
H
-
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
A
F
N
G
P
--
H
P
--------
Y
T
F
M
R
E
L
R
----------
T
N
K
--
N
Q
Q
K
A
S
E
Y
A
K
W
F
Q
K
---
Q
E
V
Q
D
Y
M
E
-
R
--
D
N
F
S
G
L
R
K
L
V
I
D
P
G
V
K
K
G
Y
L
T
A
D
-
D
V
Q
A
Y
M
N
S
W
E
N
G
S
V
L
S
M
L
S
Y
Y
R
-
N
L
K
------
I
F
T
E
---------------
E
--
D
L
R
R
K
S
---------------
L
F
---
P
L
E
E
E
V
L
N
-
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
N
L
-
D
G
I
E
E
Y
V
P
N
I
S
V
H
R
L
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
N
K
38
HHSearch
73.03
19%
-109
- C1 -
3OM8
2
?
A:
[9-265]
-----
L
A
T
S
D
G
A
S
L
A
Y
R
L
D
G
A
A-
E
K
P
L
L
A
L
S
------
N
S
I
----
G
TTLH
M
----
W
---
D
A
Q
-
L
---
P
---
A
L
---
T
R
H
F
R
V
L
R
Y
D
A
R
G
H
G
A
S
S
V
P
P
---
G
P
Y
T
L
A
R
L
G
E
D
V
L
E
L
L
D
A
L
E
V
--
R
R
A
H
F
L
G
L
-
S
L
G
G
I
V
G
Q
W
L
A
L
H
A
P
Q
R
I
E
R
L
V
L
A
N
T
S
--
A
W
--------
L
G
P
A
A
Q
W
-----------
D
E
R
I
A
-
A
V
--
L
Q
-
A
E
D
M
S
E
T
-
A
A
G
F
L
G
N
W
F
-
P
--
P
---
A
L
L
E
R
-
A
E
P
V
V
E
R
F
R
-
A
M
L
-
M
A
------
T
--------------
N
R
H
------
G
L
A
G
----
S
--------
F
-
A
--
A
V
R
D
T
D
---------------
L
R
---
A
Q
L
A
R
I
-
E
-
R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
A
-
S
H
G
E
L
I
A
A
S
I
A
G
A
R
L
V
T
L
P
-
A
V
H
L
S
N
V
E
F
P
Q
A
F
E
G
A
V
L
S
F
L
G
-
48
HHSearch
72.93
17%
-99
- C1 -
4PW0
6
?
A:
[17-282]
----
Q
Y
I
E
V
N
G
T
R
Y
A
Y
R
S
L
G
A
PS
D
I
P
L
I
-
C
F
------
Q
H
F
TGTL
D
----
N
----
W
---
D
P
L
I
T
---
N
---
G
L
---
S
K
G
R
Q
L
I
I
F
D
N
K
G
V
G
L
S
S
G
T
T
----
P
D
N
V
A
A
M
T
A
D
A
L
E
F
I
T
A
L
G
I
--
R
Y
F
D
V
L
G
F
-
S
L
G
G
F
I
V
Q
Y
M
A
H
I
Q
P
D
M
I
R
K
I
I
I
V
G
A
A
--
P
Q
--------
G
V
K
V
L
H
T
F
----------
P
-
D
L
I
A
R
A
M
Q
L
E
P
K
E
R
F
L
F
I
F
F
E
Q
S
E
H
--
S
-
R
--
S
K
G
L
A
T
L
G
R
L
Y
E
----
R
T
T
D
R
D
Q
-
D
-
A
-
S
---
A
Q
A
--------
I
G
A
-
Q
L
T
------
A
----------------
I
T
---
N
W
G
K
K
T
---------------
P
S
---
F
E
I
T
S
I
-
Q
-
H
P
V
F
V
V
Q
G
S
N
D
E
M
M
D
T
Y
-
N
S
Y
E
L
F
K
Q
L
P
D
A
I
L
S
L
Y
P
D
A
A
H
G
S
F
Y
Q
Y
P
E
L
F
V
S
Q
T
E
Y
F
L
D
S
41
HHSearch
72.04
18%
-113
- C1 -
1IUP
3
?
A:
[6-272]
--
I
G
K
S
I
L
A
A
G
V
L
T
N
Y
H
D
V
G
E
--
G
Q
P
V
I
-
L
I
------
H
G
S
----
G
----
P
GVS
A
Y
A
N
-
W
R
L
T
I
---
P
---
A
L
---
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
P
E
--
N
Y
N
Y
S
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
--
E
K
A
H
I
V
G
N
-
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
S
E
R
V
D
R
M
V
L
M
G
A
A
--
G
T
--------
R
F
D
V
T
E
G
L
----------
N
-
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
-
F
A
-
Y
D
R
S
L
V
-
T
--
D
E
L
A
R
L
R
Y
---
E
----
A
S
I
Q
P
G
F
---
Q
E
S
---
F
S
S
--------
M
----
F
P
------
E
P
R
Q
----
R
--------
W
I
D
--
A
L
A
--
S
---------------
S
D
---
E
D
I
K
T
L
-
P
-
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
-
S
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
E
Q
T
D
R
F
N
R
L
V
V
E
F
F
N
E
16
PsiBlast_PDB
71.97
19%
-93
- C1 -
4O08
5
?
A:
[43-321]
---------
N
G
V
N
L
H
Y
I
S
K
G
Q
--
G
E
L
M
L
-
F
L
------
H
G
F
----
P
----
D
----
F
---
S
H
I
W
R
---
H
---
Q
I
D
E
F
S
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
G
-
L
E
S
Y
E
I
D
V
L
V
E
D
I
R
Q
V
I
E
G
L
G
Y
--
S
S
C
T
L
V
V
H
-
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
A
F
N
-
G
--
P
H
P
Y
T
F
M
R
E
L
R
T
N
K
N
Q
Q
K
----------
A
S
E
Y
M
K
W
F
Q
K
Q
E
V
Q
D
Y
M
E
R
D
-
N
F
S
G
L
R
K
L
V
-
I
--
D
P
G
V
K
K
G
Y
L
T
A
D
-
D
V
Q
A
Y
M
N
S
W
E
-
N
G
S
V
L
S
--
M
L
S
--------
Y
Y
R
-
N
L
K
------
I
F
T
E
---------------
E
--
D
L
R
R
K
S
---------------
L
F
---
P
L
E
E
E
V
L
N
-
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
N
L
-
D
G
I
E
E
Y
V
P
N
I
S
V
H
R
L
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
N
K
12
PsiBlast_PDB
71.88
23%
-112
- C1 -
1M33
3
BIOH_ECOLI
A:
[3-245]
------------
N
I
W
W
Q
T
K
G
Q
--
G
N
V
H
L
-
V
L
L
H
G
W
--
G
L
N
----
A
----
E
----
V
---
W
R
C
I
D
---
E
---
E
L
---
S
S
H
F
T
L
H
L
V
D
L
P
G
F
G
R
----------
S
R
G
F
G
A
L
S
L
A
D
M
A
E
A
V
L
Q
Q
AP
D
K
A
I
W
L
G
W
-
S
L
G
G
L
V
A
S
Q
I
A
L
T
H
P
E
R
V
R
A
L
V
T
V
A
S
S
--
P
C
--------
F
S
A
R
D
E
W
P
----------
G
---------------
I
K
P
D
-
V
L
A
G
F
Q
Q
Q
L
-
S
--
D
D
Q
Q
R
T
V
E
R
F
L
A
L
Q
T
M
G
T
E
T
A
R
Q
-
D
A
R
A
L
---
K
K
T
--------
V
L
A
L
P
M
P
------
E
V
D
V
----
L
--------
N
G
G
L
E
I
L
K
T
V
D
---------------
L
R
---
Q
P
L
Q
N
V
-
S
-
M
P
F
L
R
L
Y
G
Y
L
D
G
L
V
-
P
R
K
V
V
P
M
L
D
K
L
W
P
H
S
E
S
Y
I
F
A
K
A
A
H
A
P
F
I
S
H
P
A
E
F
----------
52
HHSearch
71.01
17%
-112
- C1 -
4LXH
2
?
A:
[8-275]
----
K
F
I
D
C
D
G
I
R
T
H
Y
I
E
M
G
E
--
G
D
P
L
V
-
L
V
------
H
G
G
----
G
----
A
----
G
ADG
R
S
N
F
A
DN
F
P
---
I
F
---
A
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
P
A
G
F
A
Y
T
Q
A
A
R
T
D
H
L
I
S
F
I
K
A
L
G
L
--
S
K
I
C
L
I
G
N
-
A
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
--
V
N
--------
I
S
P
D
D
M
V
A
----------
N
R
D
D
L
A
A
V
--
M
S
Y
D
-
G
S
E
E
G
-
M
R
K
I
I
A
A
L
T
-
H
S
Y
Q
P
T
D
D
I
V
H
Y
R
H
E
----
A
S
L
R
P
---
T
T
T
A
A
---
Y
K
A
-------------
T
----------
M
----
G
--------
W
A
K
--
Q
N
G
L
Y
Y
---------------
S
P
---
E
Q
L
A
S
L
-
T
-
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
-
D
Q
I
L
A
I
P
Q
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
G
K
1
PsiBlast_PDB
70.86
26%
-82
- C1 -
1AZW
-
PIP_XANCI
A:
[60-307]
-----------------------------------------------------------------------------
K
Y
R
I
V
L
F
D
Q
R
G
S
G
R
S
T
P
H
A
D
-
L
V
D
N
T
T
W
D
L
V
A
D
I
E
R
L
R
T
H
L
G
V
--
D
R
W
Q
V
F
G
G
-
S
W
G
S
T
L
A
L
A
Y
A
Q
T
H
P
Q
Q
V
T
E
L
V
L
R
G
I
--------------
F
L
L
R
R
F
E
----------
L
E
W
F
Y
Q
E
G
A
S
R
L
F
P
D
A
W
E
H
Y
-
L
N
A
I
P
P
V
E
R
-
A
--
D
L
M
S
A
F
-
H
R
R
L
T
S
D
D
E
A
T
R
L
A
A
A
-
K
A
W
S
V
---
W
E
G
--------
A
T
S
-
F
L
H
------
V
D
E
D
----
F
V
T
G
H
E
D
A
H
F
A
L
--
A
F
A
R
I
E
N
H
Y
F
V
N
GGFFEVED
Q
L
L
R
D
A
H
R
I
A
D
I
----
P
G
V
I
V
H
G
R
Y
D
V
V
C
P
L
Q
S
A
W
D
-
L
H
K
A
W
P
K
A
Q
L
Q
I
S
P
A
S
G
H
S
A
F
--
E
P
E
N
V
D
A
L
V
R
-----