@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04170: (2016-06-07 )
METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAMLQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKAMFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDTALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIMLGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVILMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVKVKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDEDGFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVKNGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS
Atome Classification :
(20 SA)
.........10........20...----.-----....30........40....-....50........60........70........80........90........100.....--.-.110----.-.--..---.-------..---120--...-......130..--------.....140-----.....-------..150------.........160........170.......180........-190---....--..---.200------.......210-----....--..----...220-........--230--....----------...240.......250.......260....--...--270.......280----.......290-..-..-..------.300--.......310....-....-320.......330..-.......340.......350.....-----..360.......370-....-.-----..380.......390.......400.......410.......420.......430.......440.......450..-----.--...---.460......-.470.-..-.--...480........490.......500.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
T
L
Q
H
L
I
LHDMP
N
S
E
E
I
E
A
V
KSG----D-----
H
T
L
T
Y
K
G
Y
R
K
R
I
N
Q
L
A
N
A
M
L
-
Q
K
G
IQKG
D
R
V
A
L
L
CKNGH
P
A
S
T
V
M
F
A
A
L
EI
G
A
V
V
V
P
V
S
W
Q
LK
P
Y
E
M
T
G
I
L
KASEP
K
A
M
FY
G
A
--
E
-
F
K
E
I
----
L
-
D
--
E
V
---
L
-------
P
E
---
L
----
S
S
L
-
C
V
T
METGTAYE--------TSA
E
F
E
A
L
-----FAGPD-------HLP--------ETEMVSPDD
T
-
A
L
L
M
F
TSGTTGNP
K
R
C
M
ITH-G
G
I
Y
R
Y
V
KK-SNS---
S
I
A
R
--MK---G
L
R
F
------
L
A
CHP
I
Y
H
-------
T
S
A
L
--
I
C
----
I
M
L
G-T-FA
E
T
T
F
V
F
--TKD--QD
P
V
----------
H
M
L
K
V
I
E
E
E
K
I
Q
T
V
M
A
L
P
V
F
Y
T
Y
L
L
E
A
W
E
K
--
H
Q
T--
D
L
S
S
L
V
I
L
M
TGGT----KV
P
S
S
L
I
S
R
Y
-
L
D-IG-IP------LAHG--YGSTE
A
W
G
-
I
STWT-PDMG-MDKAASAGKPV--A
G
-
V
K
V
K
VEDPLTGEELPQGEI
G
E
I
V
V
H-----T
P
F
L
FKGYED
N
P
E
A
T
-
A
K
V
L
-
Q
-----NGWFRTGDSGYVDED
G
F
I
F
I
TGRY
K
D
V
I
I
YGGDNV
Y
P
D
Q
V
E
E
V
I
Q
Q
I
P
G
I
L
E
T
A
VVGIPDPLYGEKP
K
A
F
I
VKNGGQ-----R--I
T
E
---
E
D
V
I
A
F
C
K
E
R
-
L
S
AYK-IP-
E
--
V
E
F
V
-
N
ELPK
N
N
L
G
K
V
K
K
D
V
L
R
NQAVHS
1
PsiBlast_PDB
90.71
33%
-117
- C1 -
3R44
2
FAC13_MYCTU
A:
[39-510]
----------------------
S
T
----
D
-----
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
-
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
--
P
-
S
A
P
V
----
I
-
D
--
A
I
---
R
-------
A
Q
---
A
----
D
P
P
-
G
T
V
T
D
W
I
G
A
D
S
--------
L
A
---
E
R
L
-----
R
S
A
A
A
-------
D
E
P
--------
A
V
E
-
C
G
G
D
D
N
-
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
-
E
S
V
H
S
A
A
S
S
-
W
A
S
---
T
I
D
V
--
R
Y
---
R
D
R
L
------
L
L
P
L
P
M
F
H
-------
V
A
A
L
--
T
T
----
V
I
F
S
-
A
-
M
R
G
V
T
L
I
S
--
M
P
Q
--
F
D
A
T
----------
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
R
Q
V
P
E
F
--
A
E
L
--
D
A
P
D
F
R
Y
F
I
T
G
G
A
----
P
M
P
E
A
L
I
K
I
Y
-
A
A
-
K
N
-
I
E
------
V
V
Q
G
--
Y
A
L
T
E
S
C
G
-
G
G
T
L
L
L
S
E
D
A
-
L
R
K
A
G
S
A
G
R
A
T
MF
T
D
-
V
A
V
R
G
D
D
G
V
I
R
E
---
H
G
E
-
G
E
V
V
I
K
-----
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
-
R
D
A
F
-
D
-----
N
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
N
E
--------
V
S
E
---
Q
Q
I
V
E
Y
C
G
T
R
-
L
A
R
Y
K
-
L
P
K
K
--
V
I
F
A
-
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
----
42
HHSearch
90.38
31%
-114
- C1 -
3R44
2
FAC13_MYCTU
A:
[16-512]
-
K
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
P
ST--
D
-----
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
-
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
--
P
-
S
A
P
V
----
I
-
D
--
A
I
---
R
-------
A
Q
---
A
----
D
P
P
-
G
T
-
V
--
T
D
W
I
G
---------
A
D
S
L
A
E
R
-----
L
R
S
A
A
-------
A
D
E
--------
P
A
V
E
C
G
G
D
D
N
-
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
-
E
S
V
H
S
A
A
S
S
-
W
A
S
---
T
I
D
V
--
R
Y
---
R
D
R
L
------
L
L
P
L
P
M
F
H
-------
V
A
A
L
--
T
T
----
V
I
F
S
-
A
-
M
R
G
V
T
L
I
S
--
M
P
Q
--
F
D
A
T
----------
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
R
Q
V
P
E
F
--
A
E
L
--
D
A
P
D
F
R
Y
F
I
T
G
G
A
----
P
M
P
E
A
L
I
K
I
Y
-
A
A
-
K
N
-
I
E
------
V
V
Q
G
--
Y
A
L
T
E
S
C
G
-
G
G
T
L
L
-
L
S
E
D
A
L
R
K
A
G
S
A
G
R
A
T
--
M
F
-
T
D
V
A
V
R
G
D
D
-
G
V
I
R
-
E
H
G
E
G
E
V
V
I
K
-----
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
-
R
D
A
F
-
D
-----
N
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
A
D
Q
N
------
E
--
V
S
E
---
Q
Q
I
V
E
Y
C
G
T
R
-
L
A
R
Y
K
-
L
P
-
K
K
-
V
I
F
A
-
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
--
5
PsiBlast_PDB
86.28
28%
-105
- C1 -
5BUS
2
MENE_BACSU
A:
[28-481]
----------------------------
D
-----
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
--
S
-
F
E
K
-----------------------
K
E
---
Y
----
E
H
I
-
V
Q
T
I
D
V
D
-----------------
E
L
M
-----
K
E
A
A
E
-------
E
I
E
--------
I
E
A
Y
M
Q
M
D
A
T
-
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
-
G
N
H
Y
F
S
A
V
S
-
S
A
L
---
N
L
G
I
--
T
E
---
Q
D
R
W
------
L
I
A
L
P
L
F
H
-------
I
S
G
L
--
S
A
----
L
F
K
S
-
V
-
I
Y
G
M
T
V
V
L
--
H
Q
R
--
F
S
V
S
----------
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
--
E
T
--
N
R
C
--
P
E
S
I
R
C
I
L
L
G
G
G
P
-----
A
P
L
P
L
L
E
E
C
-
R
E
-
K
G
-
F
P
------
V
F
Q
S
--
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
-
P
E
F
S
-
M
E
K
L
G
S
A
G
K
P
L
--
F
S
-
C
E
I
K
I
E
R
--
D
G
Q
V
C
E
P
Y
E
H
G
E
I
M
V
K
-----
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
-
E
A
S
F
-
Q
-----
N
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
--
K
V
P
H
A
Y
L
V
L
H
--
K
-----
P
--
V
S
A
---
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
-
I
P
-
A
--
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
-----
2
PsiBlast_PDB
84.75
29%
-98
- C1 -
4FUQ
7
?
A:
[14-495]
----------
D
D
P
H
K
L
A
I
E
T
A
-
A
G
----
D
-----
K
-
I
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
-
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
P
L
N
T
A
Y
T
L
H
E
L
D
Y
F
I
T
D
A
E
P
K
I
V
V
C
D
P
--
S
-
K
R
D
G
----
I
-
A
--
A
I
---
A
-------
A
K
---
V
----
G
A
T
-
V
E
T
L
----
G
P
D
--------
G
R
G
S
L
T
D
A
-----
A
A
G
A
S
-------
E
A
F
--------
A
T
I
D
R
G
A
D
D
L
-
A
A
I
L
Y
T
S
--
T
G
R
S
K
G
A
M
L
S
H
-
D
N
L
-------
A
S
N
---
S
L
T
L
--
V
D
---
Y
W
R
F
TPD
D
V
L
I
H
A
L
P
I
Y
H
-------
T
H
G
L
F-
V
A
----
S
N
V
T
-
L
-
F
A
R
G
S
M
I
F
--
L
P
K
--
F
D
P
D
----------
K
I
L
D
L
M
A
R
A
T
V
--
L
M
G
V
P
T
F
Y
T
R
L
L
Q
S
P
R
L
--
T
K
E
--
T
T
G
H
M
R
L
F
I
S
G
S
A
----
P
L
L
A
D
T
H
R
E
W
S
A
K
-
T
G
-
H
A
------
V
L
E
R
--
Y
G
M
T
E
T
-
N
-
M
N
T
S
N
-
P
Y
D
G
-
D
R
V
P
G
A
V
G
P
A
L
--
P
G
-
V
S
A
R
V
T
D
P
E
T
G
K
E
L
P
R
G
D
I
G
M
I
E
V
K
-----
G
P
N
V
F
K
G
Y
W
R
M
P
E
K
T
K
S
E
F
R
-
D
-----
D
G
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
P
G
V
V
E
S
A
V
I
G
V
P
H
A
D
F
G
E
G
V
T
A
V
V
V
R
D
K
G
A
-----
T
--
I
D
E
---
A
Q
V
L
H
G
L
D
G
Q
-
L
A
K
F
K
-
M
P
K
K
--
V
I
F
V
-
D
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
R
------
4
PsiBlast_PDB
84.13
28%
-102
- C1 -
5BUR
8
MENE_BACSU
A:
[28-481]
----------------------------
D
-----
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
--
S
-
F
E
K
-----------------------
K
E
---
Y
----
E
H
I
-
V
Q
T
I
D
V
D
-----------------
E
L
M
-----
K
E
A
A
E
-------
E
I
E
--------
I
E
A
Y
M
Q
M
D
A
T
-
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
-
G
N
H
Y
F
S
A
V
S
-
S
A
L
---
N
L
G
I
--
T
E
---
Q
D
R
W
------
L
I
A
L
P
L
F
H
-------
I
S
G
L
--
S
A
----
L
F
K
S
-
V
-
I
Y
G
M
T
V
V
L
--
H
Q
R
--
F
S
V
S
----------
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
--
E
T
--
N
R
C
--
P
E
S
I
R
C
I
L
L
G
G
G
P
-----
A
P
L
P
L
L
E
E
C
-
R
E
-
K
G
-
F
P
------
V
F
Q
S
--
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
-
P
E
F
S
-
M
E
K
L
G
S
A
G
K
P
L
--
F
S
-
C
E
I
K
I
E
R
--
D
G
Q
V
C
E
P
Y
E
H
G
E
I
M
V
K
-----
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
-
E
A
S
F
-
Q
-----
N
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
--
G
K
V
P
H
A
Y
L
V
L
H
--
K
-----
P
--
V
S
A
---
G
E
L
T
D
Y
C
K
E
R
-
L
A
K
Y
K
-
I
P
-
A
--
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
-----
10
PsiBlast_PDB
83.99
29%
-119
- C1 -
3G7S
-
?
A:
[62-522]
-----------------------------------------------
K
L
A
S
G
I
S
-
R
K
G
V
R
K
G
E
H
V
G
V
C
I
P
N
S
I
D
Y
V
M
T
I
Y
A
L
W
R
V
A
A
T
P
V
P
I
N
P
M
Y
K
S
F
E
L
E
H
I
L
N
D
S
E
A
T
T
L
V
V
H
S
--
M
-
L
Y
E
N
----
F
-
K
--
P
V
---
L
-------
E
K
---
T
----
G
V
E
-
R
V
F
V
V
G
G
---
E
--------
V
N
S
L
S
E
V
M
-----
D
S
G
S
E
-------
D
F
E
--------
N
V
K
V
N
P
E
E
D
V
-
A
L
I
P
Y
T
G
G
T
T
G
-
P
K
G
V
M
L
T
H
-
F
N
L
A
A
N
A
L
Q
-
L
A
V
---
A
T
G
L
--
S
H
---
M
D
T
I
------
V
G
C
M
P
M
F
H
-------
S
A
E
F
--
G
L
----
V
N
L
M
-
V
-
T
V
G
N
E
Y
V
V
--
M
G
M
--
F
N
Q
E
----------
M
L
A
E
N
I
E
K
Y
K
G
T
F
S
W
A
V
P
P
A
L
N
V
L
V
N
T
L
E
S
--
S
N
K
T
Y
D
W
S
Y
L
K
V
F
A
T
G
A
W
----
P
V
A
P
A
L
V
E
K
L
-
L
K
-
L
A
-
A
E
KCNNPR
L
R
H
N
Q
I
W
G
M
T
E
A
C
P
-
M
V
T
T
N
-
P
P
L
R
-
L
D
K
S
T
T
Q
G
V
P
M
--
S
D
-
I
E
L
K
V
I
S
L
E
D
G
R
E
L
G
V
G
E
S
G
E
I
V
I
R
-----
G
P
N
I
F
K
G
Y
W
K
R
E
K
E
N
-
Q
E
C
W
-
W
Y
D
EKG
R
K
F
F
R
T
G
D
V
G
F
I
D
E
E
G
F
L
H
F
Q
D
R
V
------------
P
F
E
L
E
A
L
L
M
K
H
E
A
V
M
D
V
A
V
I
G
K
P
D
------
P
K
A
F
I
V
L
K
P
E
Y
-----
R
GK
V
D
E
---
E
D
I
I
E
W
V
R
E
R
-
I
S
-----
R
-
E
--
V
E
F
V
-
E
E
L
P
-------------------
30
HHSearch
83.90
27%
-93
* C1 *
2D1S
3
LUCI_LUCCR
A:
[24-543]
--
S
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
A
F
T
NAVT
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
--
K
-
G
L
D
K
----
V
-
I
--
T
V
---
Q
-------
K
T
VTT
I
----
K
T
I
-
V
I
-
L
D
S
K
V
D
Y
R
--------
G
Y
Q
C
L
D
T
F
-----
I
K
R
N
T
PPGFQAS
S
F
K
--------
T
V
E
V
D
R
K
E
Q
V
-
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
-
E
N
I
V
T
R
F
S
H
-
A
R
D
PIY
G
N
Q
V
--
S
P
---
G
T
A
V
------
L
T
V
V
P
F
H
H
-------
G
F
G
M
--
F
T
----
T
L
G
Y
-
L
-
I
C
G
F
R
V
V
M
--
L
T
K
--
F
D
E
E
----------
T
F
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
L
L
--
N
K
Y
--
D
L
S
N
L
V
E
I
A
S
G
G
A
----
P
L
S
K
E
V
G
E
A
V
-
A
R
R
F
N
L
P
G
------
V
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
I
I
T
-
P
E
G
--
D
D
K
P
G
A
S
G
K
V
V
--
P
L
-
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
-
K
E
L
I
-
D
E----
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
V
V
V
L
E
S
G
K
-----
N
--
M
T
E
---
K
E
V
M
D
Y
V
A
S
Q
-
V
S
N
A
K
R
L
R
-
G
G
-
V
R
F
V
-
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
K
-
34
HHSearch
83.85
27%
-103
- C1 -
4WV3
1
?
A:
[12-517]
---
A
V
D
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
F
T
P
----
D
-----
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
--
E
-
F
L
P
L
----
I
-
E
--
S
I
---
R
-------
G
N
---
L
PML-
E
H
I
-
V
V
-
I
G
-----
G
---------
Y
L
S
F
N
D
W
-----
I
R
P
Q
P
-------
T
T
L
--------
E
A
A
Q
S
H
R
E
D
I
-
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
-
K
D
Y
P
L
T
A
Q
L
W
G
V
N
---
V
L
G
L
--
R
E
---
S
D
R
T
------
F
A
L
A
K
L
F
F
-------
T
F
G
T
--
G
G
----
N
L
I
F
-
P
W
Y
V
G
A
S
C
V
L
--
F
P
G
AA
R
V
A
S
----------
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
F
--
S
Q
H
--
D
L
S
S
L
R
L
C
V
S
A
S
E
----
A
L
P
A
A
L
W
Y
A
W
-
K
E
A
T
G
-
V
D
------
I
I
D
G
--
I
G
C
T
E
N
F
H
-
I
F
I
S
N
-
R
P
G
--
D
I
R
P
G
S
S
G
K
P
V
--
E
G
-
Y
E
L
K
L
V
D
D
E
-
G
K
T
V
P
A
G
E
I
G
N
V
L
L
R
-----
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
-
R
Q
T
F
-
Q
-----
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
I
P
S
--
E
--
A
L
I
---
R
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
-
R
P
-
R
W
-
I
E
F
V
-
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
--
11
PsiBlast_PDB
83.26
27%
-129
- C- -
3IPL
-
MENE_STAAN
A:
[17-477]
-------------------
A
I
T
D
G
----
Q
-----
E
S
Y
T
Y
Q
N
L
Y
C
E
A
S
L
L
A
K
R
L
---
K
A
Y
Q
Q
S
-
R
V
G
L
Y
I
D
N
S
I
Q
S
I
I
L
I
H
A
C
W
L
A
N
I
E
I
A
M
I
N
T
R
L
T
P
N
E
M
T
N
Q
M
R
S
I
D
V
Q
L
I
F
C
T
L
P
L
E
-
L
R
G
F
QIVS
L
-
D
--
D
-----------------------------------------------------------
E
S
P
S
-------
N
I
L
--------
N
T
S
F
-
N
L
D
D
I
-
A
S
I
M
F
T
S
G
T
T
G
P
Q
K
A
V
P
Q
T
F
-
R
N
H
Y
A
S
A
I
G
-
C
K
E
---
S
L
G
F
--
D
R
---
D
T
N
W
------
L
S
V
L
P
I
Y
H
-------
I
S
G
L
--
S
V
----
L
L
R
A
-
V
-
I
E
G
F
T
V
R
I
--
V
D
K
--
F
N
A
E
----------
Q
I
L
T
M
I
K
N
E
R
I
T
H
I
S
L
V
P
Q
T
L
N
W
L
M
Q
Q
G
L
H
--
E
P
Y
--
N
L
Q
K
I
L
L
---
G
G
A
----
K
L
S
A
T
M
I
E
T
A
-
L
Q
-
Y
N
-
L
P
------
I
Y
N
S
--
F
G
M
T
E
T
C
S
Q
F
L
T
A
T
-
P
E
M
L
-
H
A
R
P
D
T
V
G
M
P
S
--
A
N
-
V
D
V
K
I
K
N
P
N
-----
K
E
G
H
-
G
E
L
M
I
K
-----
G
A
N
V
M
N
G
Y
L
-
Y
P
T
D
L
-
T
G
T
F
-
E
-----
N
G
Y
F
N
T
G
D
I
A
E
I
D
H
E
G
Y
V
M
I
Y
D
R
R
K
D
L
I
I
S
G
G
E
N
I
Y
P
Y
Q
I
E
T
V
A
K
Q
F
P
G
I
S
D
A
V
C
V
G
H
P
D
D
T
W
G
Q
V
P
K
L
Y
F
V
S
E
S
D
---------
I
S
K
---
A
Q
L
I
A
Y
L
S
K
H
-
L
A
K
Y
K
-
V
P
-
K
H
-
F
E
K
V
-
D
T
L
P
-------------------
20
PsiBlast_PDB
83.17
28%
-123
- C1 -
1LCI
-
LUCI_PHOPY
A:
[50-536]
-----------------------------------
N
I
T
Y
A
E
Y
F
E
M
S
V
R
L
A
E
A
M
K
-
R
Y
G
L
N
T
N
H
R
I
V
V
C
S
E
N
S
L
Q
F
F
M
P
V
L
G
A
L
F
I
G
V
A
V
A
P
A
N
D
I
Y
N
E
R
E
L
L
N
S
M
N
I
S
Q
P
T
V
V
F
V
S
K
--
K
G
L
Q
K
I
----
L
-
N
V
Q
K
K
---
L
-------
P
I
---
I
----
Q
K
I
-
I
I
-
M
D
S
K
T
D
Y
Q
GFQS
M
Y
T
F
V
T
S
H
L
P
P
G
-----
F
N
E
Y
D
-------
F
V
P
--------
E
S
--
F
D
R
D
K
T
I
A
L
I
M
N
S
-----
L
P
K
G
V
A
L
P
H
R
T
A
C
V
R
F
S
H
A
-
R
D
P
---
I
F
G
N
QI
I
P
---
D
T
A
I
------
L
S
V
V
P
F
H
H
GFGM
F
T
T
L
G
Y
L
--
I
C
G
F
R
V
V
L
M
Y
-
R
-
F
E
E
E
L
F
-------------------------
L
R
S
L
Q
D
Y
K
I
Q
S
A
L
L
V
P
T
L
F
S
F
F
A
K
S
T
L
I
--
D
K
Y
--
D
L
S
N
L
H
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
K
R
F
-
H
L
-
P
G
-
I
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
L
I
T
-
P
E
-
G
----
P
G
A
V
G
K
V
V
--
P
F
-
F
E
A
K
V
V
D
L
D
T
G
K
T
L
G
V
N
Q
R
G
E
L
C
V
R
-----
G
P
M
I
M
S
G
Y
V
N
N
P
E
A
T
N
A
L
I
D
-
K
-----
D
G
W
L
H
S
G
D
I
A
Y
W
D
E
D
E
H
F
F
I
V
-----
L
I
K
Y
K
G
Y
Q
V
A
P
A
E
L
E
S
I
L
L
Q
H
P
N
I
F
D
A
G
V
A
G
L
P
D
D
D
A
G
E
L
P
A
A
V
V
V
L
E
H
G
K
-----
T
--
M
T
E
---
K
E
I
V
D
Y
V
A
S
Q
-
V
T
T
A
K
-
K
L
-
R
G
G
V
V
F
V
-
D
E
V
P
K
-----
L
D
A
R
K
I
R
------
41
HHSearch
82.52
26%
-101
- C1 -
4IZ6
2
ENTE_ECOLI
A:
[57-554]
---------------
S
D
S
I
A
V
I
D
G
----
E
-----
R
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
--
Q
-
H
A
L
F
----
S
-
G
--
D
D
F
--
L
-------
N
T
---
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
N
D
S
G
-----------
E
H
N
L
Q
D
A
-----
I
N
H
P
A
-------
E
D
F
--------
T
A
T
P
S
P
A
D
E
V
-
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
-
N
D
Y
Y
Y
S
V
R
R
-
S
V
E
---
I
C
Q
F
--
T
Q
---
Q
T
R
Y
------
L
C
A
I
P
A
A
H
-------
N
Y
A
M
--
S
S
PG--
S
L
G
V
-
F
-
L
A
G
G
T
V
V
L
--
A
A
D
--
P
S
A
T
----------
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
GE
S
R
A
--
Q
L
A
S
L
K
L
L
Q
V
G
G
A
----
R
L
S
A
T
L
A
A
R
I
-
P
A
E
I
G
-
C
Q
------
L
Q
Q
V
--
F
G
M
A
E
G
L
V
-
N
Y
T
R
L
-
D
D
S
A
-
E
K
I
I
H
T
Q
G
Y
P
M
C-
P
D
-
D
E
V
W
V
A
D
A
E
-
G
N
P
L
P
Q
G
E
V
G
R
L
M
T
R
-----
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
-
A
S
A
F
-
D
A----
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
E
P
---------
L
R
A
---
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
-
L
P
-
D
R
-
V
E
C
V
-
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
---
15
PsiBlast_PDB
82.41
27%
-104
- C1 -
4G37
4
LUCI_PHOPY
A:
[55-541]
-----------------------------------
N
I
T
Y
A
E
Y
F
E
M
S
V
R
L
A
E
A
M
K
-
R
Y
G
L
N
T
N
H
R
I
V
V
S
S
E
N
S
L
Q
F
F
M
P
V
L
G
A
L
F
I
G
V
A
V
A
P
A
N
D
C
Y
N
E
R
E
L
L
N
S
M
N
I
S
Q
P
T
V
V
F
V
S
K
--
K
G
L
Q
K
I
----
L
-
N
V
Q
K
K
---
L
-------
P
I
---
I
----
Q
K
I
-
I
I
-
M
D
S
K
T
D
Y
Q
GFQS
M
Y
T
F
V
T
S
H
L
P
P
G
-----
F
N
E
Y
D
-------
F
V
P
--------
E
S
--
F
D
R
D
K
T
I
A
L
I
M
N
S
S
-----
P
K
G
V
A
L
P
H
-
R
A
L
A
V
R
F
S
H
-
A
R
D
---
P
I
F
G
--
N
Q
IAP
D
T
A
I
------
L
S
V
V
P
F
H
H
-------
G
F
G
M
--
F
T
----
T
L
G
Y
-
L
-
I
S
G
F
R
V
V
L
--
M
Y
R
--
F
E
E
E
----------
L
F
L
R
S
L
Q
D
Y
K
I
Q
S
A
L
L
V
P
T
L
F
S
F
L
A
K
S
T
L
I
--
D
K
Y
--
D
L
S
N
L
H
E
I
A
S
G
G
A
PLS
K
E
V
G
E
A
V
A
K
R
F
-
H
L
-
P
G
-
I
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
L
I
T
-
P
K
-
G
-
D
D
K
P
G
A
V
G
K
V
V
--
P
F
-
F
E
A
K
V
V
D
L
D
T
G
K
T
L
G
V
N
Q
R
G
E
L
S
V
R
-----
G
P
M
I
M
S
G
Y
V
N
N
P
E
A
T
N
A
L
I
D
-
K
-----
D
G
W
L
H
S
G
D
I
A
Y
W
D
E
D
E
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
C
Q
V
A
P
A
E
L
E
S
I
L
L
Q
H
P
N
I
F
D
A
G
V
A
G
L
P
D
D
D
A
G
E
L
P
A
A
V
V
V
L
E
H
G
K
-----
T
--
M
T
E
---
K
E
I
V
D
Y
V
A
S
Q
-
V
T
T
A
K
-
K
L
-
R
G
G
V
V
F
V
-
D
E
V
P
K
G
L
--
K
L
D
A
R
K
I
R
------
43
HHSearch
82.01
28%
-102
- C1 -
1MDB
4
DHBE_BACSU
A:
[26-530]
--
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
C
G
----
N
-----
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
P
D
--
A
-
Y
S
G
F
----
D
Y
R
--
S
L
---
A
R
Q
V
Q
S
K
L
P
T
---
L
----
K
N
I
-
I
V
-
A
--
G
E
A
------------
E
E
F
L
P
L
-----
E
D
L
H
T
-------
E
P
V
--------
K
L
P
E
V
K
S
S
D
V
-
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
-
D
D
Y
I
Y
S
L
K
R
-
S
V
E
---
V
C
W
L
--
D
H
---
S
T
V
Y
------
L
A
A
L
P
M
A
H
-------
N
Y
P
L
--
S
S
P---
G
V
L
G
V
L
-
Y
A
G
G
R
V
V
L
--
S
P
S
--
P
S
P
D
----------
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
A
S
S
--
R
R
D
--
D
L
S
S
L
Q
V
L
Q
V
G
G
A
----
K
F
S
A
E
A
A
R
R
V
-
K
A
V
F
G
-
C
T
------
L
Q
Q
V
--
F
G
M
A
E
G
L
V
-
N
Y
T
R
L
-
D
D
P
E
-
E
I
I
V
N
T
Q
G
K
P
M
--
S
P
Y
D
E
S
R
V
W
D
D
H
-
D
R
D
V
K
P
G
E
T
G
H
L
L
T
R
-----
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
-
A
A
S
F
-
T
E----
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
--------
P
K
A
---
A
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
-
I
P
-
D
R
-
V
E
F
V
-
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
--
13
PsiBlast_PDB
81.81
28%
-101
- C1 -
4WV3
1
?
A:
[15-516]
------
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
F
T
P
----
D
-----
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
--
E
-
F
L
P
L
----
I
-
E
--
S
I
RGN
L
-------
P
M
---
L
----
E
H
I
-
V
V
I
G
---------------
G
Y
L
S
F
N
D
W
-----
I
R
P
Q
P
-------
T
T
L
--------
E
A
A
Q
S
H
R
E
D
I
-
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
---------
K
-
D
Y
P
---
L
T
A
Q
--
L
W
---
G
V
N
V
------
L
G
L
R
E
S
D
R
-------
T
F
A
L
AK
L
F
----
F
T
F
G
-
T
-
G
G
N
L
I
F
P
W
--
Y
V
G
--
A
S
C
V
L
F
PGAARV
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
F
--
S
Q
H
--
D
L
S
S
L
R
L
C
V
S
A
S
E
----
A
L
P
A
A
L
W
Y
A
W
-
K
E
A
T
G
-
V
D
------
I
I
D
G
--
I
G
C
T
E
N
F
H
-
I
F
I
-
S
-
N
R
P
G
-
D
I
R
P
G
S
S
G
K
P
V
--
E
G
-
Y
E
L
K
L
V
D
D
-
E
G
K
T
V
P
A
G
E
I
G
N
V
L
L
R
-----
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
-
R
Q
T
F
-
Q
-----
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
-----
I
--
P
S
E
A
L
I
R
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
-
R
P
-
R
W
-
I
E
F
V
-
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
---
7
PsiBlast_PDB
81.65
30%
-91
- C1 -
2D1R
2
LUCI_LUCCR
A:
[54-538]
-------------------------------------
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
------
K
K
G
----
L
-
D
--
K
V
---
I
--------
T
---
V
----
Q
K
T
-
V
T
T
I
K
T
I
V
I
L
D
--------
S
K
V
D
Y
R
G
Y
QCLDT
F
I
K
R
N
-------
T
P
P
GFQASSFK
T
V
E
V
D
R
K
E
Q
V
-
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
-
E
N
I
V
T
R
F
S
H
-
A
R
D
---
P
I
Y
G
--
N
Q
VSP
G
T
A
V
------
L
T
V
V
P
F
H
H
GFGMFTT
L
G
Y
L
--
I
C
GFRV
V
M
L
T
-
K
-
F
D
E
E
T
F
-------------------------
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
L
L
--
N
K
Y
--
D
L
S
N
L
V
E
I
A
S
G
G
A
PLSK
E
V
G
E
A
V
A
R
R
F
-
N
L
-
P
G
-
V
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
I
I
T
-
P
E
-
G
-
D
D
K
P
G
A
S
G
K
V
V
--
P
L
-
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
-
K
E
L
I
D
E
-----
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
V
V
V
L
E
S
G
K
-----
N
--
M
T
E
---
K
E
V
M
D
Y
V
A
S
Q
-
V
S
N
A
K
-
R
L
-
R
GG
V
R
F
V
-
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
------
8
PsiBlast_PDB
81.22
30%
-91
- C1 -
2D1S
3
LUCI_LUCCR
A:
[54-538]
-------------------------------------
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
------
K
K
G
----
L
-
D
--
K
V
---
I
--------
T
---
V
----
Q
K
T
-
V
T
T
I
K
T
I
V
I
L
D
--------
S
K
V
D
Y
R
G
Y
Q
C
L
D
T
F
I
K
R
N
-------
T
P
P
GFQAS
S
F
K
T
V
E
V
D
R
K
E
Q
V
-
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
-
E
N
I
V
T
R
F
S
H
-
A
R
D
---
P
I
Y
G
--
N
Q
VSP
G
T
A
V
------
L
T
V
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
--
I
C
GFRV
V
M
L
T
-
K
-
F
D
E
E
T
F
-------------------------
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
L
L
--
N
K
Y
--
D
L
S
N
L
V
E
I
A
S
G
G
A
PL
S
K
E
V
G
E
A
V
A
R
R
F
-
N
L
-
P
G
-
V
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
I
I
T
-
P
E
-
G
-
D
D
K
P
G
A
S
G
K
V
V
--
P
L
-
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
-
K
E
L
I
D
E
-----
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
V
V
V
L
E
S
G
K
-----
N
--
M
T
E
---
K
E
V
M
D
Y
V
A
S
Q
-
V
S
N
A
K
-
R
L
-
R
G
G
V
R
F
V
-
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
------
19
PsiBlast_PDB
80.95
28%
-109
- C1 -
1BA3
2
LUCI_PHOPY
A:
[50-536]
-----------------------------------
N
I
T
Y
A
E
Y
F
E
M
S
V
R
L
A
E
A
M
K
-
R
Y
G
L
N
T
N
H
R
I
V
V
C
S
E
N
S
L
Q
F
F
M
P
V
L
G
A
L
F
I
G
V
A
V
A
P
A
N
D
I
Y
N
E
R
E
L
L
N
S
M
N
I
S
Q
P
T
V
V
F
V
S
K
--
K
G
L
Q
K
I
----
L
-
N
V
Q
K
K
---
L
-------
P
I
---
I
----
Q
K
I
-
I
I
-
M
D
S
K
T
D
Y
Q
GFQS
M
Y
T
F
V
T
S
H
L
P
P
G
-----
F
N
E
Y
D
-------
F
V
P
--------
E
S
--
F
D
R
D
K
T
I
A
L
I
M
N
S
--
S
T
G
L
P
K
G
V
A
L
P
H
R
T
A
C
V
R
F
S
H
A
-
R
D
P
---
I
F
G
N
QI
I
P
---
D
T
A
I
------
L
S
V
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
--
I
C
G
F
R
V
V
L
M
Y
-
R
-
F
E
E
E
L
F
-------------------------
L
R
S
L
Q
D
Y
K
I
Q
S
A
L
L
V
P
T
L
F
S
F
F
A
K
S
T
L
I
--
D
K
Y
--
D
L
S
N
L
H
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
K
R
F
-
H
L
-
P
G
-
I
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
L
I
T
-
P
E
-
G
-
D
D
K
P
G
A
V
G
K
V
V
--
P
F
-
F
E
A
K
V
V
D
L
D
T
G
K
T
L
G
V
N
Q
R
G
E
L
C
V
R
-----
G
P
M
I
M
S
G
Y
V
N
N
P
E
A
T
N
A
L
I
D
-
K
-----
D
G
W
L
H
S
G
D
I
A
Y
W
D
E
D
E
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
A
P
A
E
L
E
S
I
L
L
Q
H
P
N
I
F
D
A
G
V
A
G
L
P
D
D
D
A
G
E
L
P
A
A
V
V
V
L
E
H
G
K
-----
T
--
M
T
E
---
K
E
I
V
D
Y
V
A
S
Q
-
V
T
T
A
K
-
K
L
-
R
G
G
V
V
F
V
-
D
E
V
P
K
G
L
T
G
K
L
D
A
R
K
I
R
------
9
PsiBlast_PDB
80.60
30%
-90
- C1 -
2D1T
3
LUCI_LUCCR
A:
[54-538]
-------------------------------------
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
------
K
K
G
----
L
-
D
--
K
V
---
I
--------
T
---
V
----
Q
K
T
-
V
T
T
I
K
T
I
V
I
L
D
--------
S
K
V
D
Y
R
G
Y
Q
C
L
D
T
F
I
K
R
N
-------
T
P
P
GYQAS
S
F
K
T
V
E
V
D
R
K
E
Q
V
-
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
-
E
N
I
V
T
R
F
S
H
-
A
R
D
---
P
I
Y
G
--
N
Q
VSP
G
T
A
V
------
L
T
V
V
P
F
H
H
G
F
G
M
F
T
T
L
G
Y
L
--
I
C
GFRV
V
M
L
T
-
K
-
F
D
E
E
T
F
-------------------------
L
K
T
L
Q
D
Y
K
C
T
N
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
L
L
--
N
K
Y
--
D
L
S
N
L
V
E
I
A
S
G
G
A
PL
S
K
E
V
G
E
A
V
A
R
R
F
-
N
L
-
P
G
-
V
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
I
I
T
-
P
E
-
G
-
D
D
K
P
G
A
S
G
K
V
V
--
P
L
-
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
-
K
E
L
I
D
E
-----
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
V
V
V
L
E
S
G
K
-----
N
--
M
T
E
---
K
E
V
M
D
Y
V
A
S
Q
-
V
S
N
A
K
-
R
L
-
R
G
G
V
R
F
V
-
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
------
6
PsiBlast_PDB
80.48
30%
-97
- C1 -
2D1Q
1
LUCI_LUCCR
A:
[54-538]
-------------------------------------
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
------
K
K
G
----
L
-
D
--
K
V
---
I
--------
T
---
V
----
Q
K
T
-
V
T
T
I
K
T
I
V
I
L
D
--------
S
K
V
D
Y
R
G
Y
QCLDT
F
I
K
R
N
-------
T
P
P
GFQASSFK
T
V
E
V
D
R
K
E
Q
V
-
A
L
I
M
N
S
S
----
L
P
K
G
V
Q
L
T
H
-
E
N
I
V
T
R
F
S
H
-
A
R
D
---
P
I
Y
G
--
N
Q
VSP
G
T
A
V
------
L
T
V
V
P
F
H
H
GFGMFTT
L
G
Y
L
--
I
C
GFRV
V
M
L
T
-
K
-
F
D
E
E
T
F
-------------------------
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
L
L
--
N
K
Y
--
D
L
S
N
L
V
E
I
A
S
G
G
A
PLSK
E
V
G
E
A
V
A
R
R
F
-
N
L
-
P
G
-
V
--------
R
Q
G
--
Y
G
L
T
E
T
T
S
-
A
I
I
I
T
-
P
E
-
G
-
D
D
K
P
G
A
S
G
K
V
V
--
P
L
-
F
K
A
K
V
I
D
L
D
T
K
K
S
L
G
P
N
R
R
G
E
V
C
V
K
-----
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
-
K
E
L
I
D
E
-----
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
V
V
V
L
E
S
G
K
-----
N
--
M
T
E
---
K
E
V
M
D
Y
V
A
S
Q
-
V
S
N
A
K
-
R
L
-
R
GG
V
R
F
V
-
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
------
32
HHSearch
80.20
24%
-109
- C1 -
3C5E
7
ACS2A_HUMAN
A:
[54-561]
------------
G
K
R
P
P
S
P
A
L
W
W
V
----
N
GKG
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
--
E
-
V
I
Q
E
----
V
-
D
--
T
V
---
A
-------
S
E
CPS
L
----
R
I
K
-
L
L
-
V
S
-
E
K
S
C
D
--------
G
W
L
N
F
K
K
L
-----
L
N
E
A
S
-------
T
T
H
--------
H
C
V
E
T
G
S
Q
E
A
-
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
-
S
S
L
G
L
K
A
K
M
-
D
A
G
---
W
T
G
L
--
Q
A
---
S
D
I
M
------
W
T
I
S
D
T
G
W
-------
I
L
N
I
--
L
C
----
S
L
M
E
-
P
W
A
L
G
A
C
T
F
V
H
L
L
P
K
--
F
D
P
L
----------
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
L
---
S
S
Y
--
K
F
P
H
L
Q
N
C
V
T
V
G
E
----
S
L
L
P
E
T
L
E
N
W
-
R
A
Q
T
G
-
L
D
------
I
R
E
S
--
Y
G
Q
T
E
T
G
L
-
T
C
M
V
S
-
K
T
-
M
-
K
I
K
P
G
Y
M
G
T
A
A
--
S
C
-
Y
D
V
Q
I
I
D
D
K
-
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
R
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
A
N
I
-
R
-----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
LSHD
P
E
--
Q
L
T
---
K
E
L
Q
Q
H
V
K
S
V
-
T
A
P
Y
K
-
Y
P
-
R
K
-
I
E
F
V
-
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
--