@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04270: (2016-06-07 )
MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPAEYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFLMSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYNMNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNGFLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGRYSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGYMSGTQTHSFDNLLPLLAERKLFNENIIQ
Atome Classification :
(20 SA)
.........10........20........30........40..--....-----..50...-.-----------.-...60--.....------.--------...70........80.----..-----.....90........100-------..--------.---.....110..------.------.------..-.120.......130---........140.-----......150.-......160-.--.----.-.-------------------..------..170--.--.--.----.----------.----------....180.----.....-.-190------------..---.-----.------...200.......---.210-..---.--..----.-----.220......----------.----------230---.---.---.-....240......--.250----..-------.------.-.---..----260--....---.....-----270...------.--.....280.....--..290.......300.-----......310.......320........330.------.--..--...340......--.350...-....360-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
H
V
L
I
A
V
I
L
F
F
L
S
IGLSAGCAEAGNKTQNQSATEVNASPLQ
P
--
A
E
Y
F
-----
I
Y
H
NLMN-D-----------K-G
L
I
K---TDFSD------Q--------
P
S
Y
L
S
E
S
L
G
L
W
M
E
F
L
L----SK-----NDAP
H
F
Q
D
Q
Y
Q
H
L
T
D
S
F
--------
L
M--------S---N
H
L
V
T
W
K
IQN------G------Q------AS-GT
N
A
L
I
D
D
M
R
I
M
L
----
S
L
D
Q
A
A
A
KWGR
S
-----
D
Y
A
Q
T
A
R
D
IG-TS
L
K
T
YNM--N--N----
G
-
F
-------------------
F
T
------DFY----D--S--Q----A----------A----------SK
D
V
T
L
S
Y----VM
P
D
A
-
L
-
A
V
L
------------
K
K---N-----G------IIDE-ETEQRNA
N
---
V
L
Y
S-AP---L--KN----G-----FLPKTYSSET----------K----------
E
Y
T---Y---D---S-E
I
N
L
I
D
Q
L
Y
A
AWH--LPEG----
D
E
-------
K
------
A
-
S
---
V
L
----
A
----
D
W
I
K
---
Q
E
F
Q
K-----N--G
K
L
------
Y
--
G
R
YSAYTKEPAVQ--YESPS
V
Y
A
L
A
V
L
F
L
TK-----QHEN
S
S
V
I
K
A
I
Y
D
RMNDF-EIHD
P
V
K
S
YYGG------Y--MS--GTQTH
S
F
D
N
L
L
P
--
L
L
A
E
R
K
L-FNENIIQ-----------------------
7
HHSearch
72.81
24%
-66
- C4 -
3REN
12
?
A:
[20-349]
-------------------------------------
H
M
E
E
K
M
--
L
F
D
F
-----
I
E
K
D
L
S
K
S
G
-----------
Y
-
G
I
Y
T
---
N
Y
I
D
K
------
S
SEGDITKG
H
S
V
L
S
E
S
E
G
L
M
M
L
Y
S
V
----
N
A
-----
N
N
K
E
L
F
D
E
H
F
D
I
V
K
E
M
R
--------
L
---------
K
---
N
G
L
I
S
W
R
K
E
G
------
D
------
E
------
N
S
-
P
S
S
A
T
I
D
E
L
R
I
I
K
----
A
L
L
L
A
N
N
R
W
N
S
F
-----
Y
Y
K
F
Y
A
I
N
I
A
-
N
S
L
L
K
H
A
E
--
E
--
N
----
E
-
T
-------------------
L
V
------
D
Y
I
----
D
--
N
--
Y
----
G
----------
K
----------
G
N
T
T
T
L
C
Y
----
L
D
L
P
T
-
M
-
K
L
L
------------
S
Q
---
V
-----
D
------
K
K
W
E
-
G
I
Y
E
K
S
N
S
---
I
I
E
N
-
G
K
---
I
SE
E
V
----
P
-----
L
Y
R
K
V
F
Y
E
E
T
----------
Q
----------
K
Y
D
---
E
---
E
---
E
-
N
V
D
F
L
L
S
T
I
V
I
L
N
--
R
I
E
A
----
G
E
-------
N
------
E
-
E
---
S
S
----
I
----
K
W
I
K
---
E
K
F
K
K
-----
D
--
G
F
L
------
V
--
A
T
Y
N
G
K
N
G
D
A
T
S
Q
--
I
E
S
P
S
I
Y
S
N
V
A
L
I
A
N
Y
-----
I
-
G
D
K
E
L
F
N
K
A
I
D
K
L
K
Y
Y
-
Q
I
K
N
K
D
S
V
L
Y
G
G
------
F
--
G
D
EK
T
N
S
V
Y
S
F
D
N
L
N
A
--
L
L
A
F
Q
K
Y
-
K
-----------------------------
1
PsiBlast_PDB
72.14
24%
-61
- C4 -
3REN
13
?
A:
[14-347]
--------------------
L
V
P
R
G
S
H
M
E
E
K
M
L
F
D
F
I
E
K
D
L
S
K
--
S
G
Y
G
-----
I
Y
T
N
Y
I
D
-
K
-----------
S
-
S
--
E
---
G
D
I
T
K
------
G
--------
H
S
V
L
S
E
S
E
G
L
M
M
L
Y
S
V
----
N
A
-----
N
N
K
E
L
F
-
D
E
H
F
D
I
V
K
E
M
--------
R
L
--------
K
---
N
G
L
I
S
W
R
K
E
G
------
D
------
E
------
N
S
-
P
S
S
A
T
I
D
E
L
R
I
I
K
----
A
L
L
L
A
N
N
R
W
N
S
F
-----
Y
Y
K
F
Y
A
I
N
I
A
-
N
S
L
L
K
H
A
E
--
E
--
N
----
E
-
T
-------------------
L
V
------
D
Y
I
----
D
--
N
--
Y
----
G
----------
K
----------
G
N
T
T
T
L
C
Y
----
L
D
L
P
T
-
M
-
K
L
L
S
Q
V
DK
K
W
E
G
I
Y
E
K
S
---
N
-----
S
------
I
I
E
-------
N
G
K
---
I
S
E
E
-
V
P
---
L
---------------
Y
R
K
V
F
Y
E
E
T
----------
Q
----------
K
Y
D
---
E
---
E
---
E
-
N
V
D
F
L
L
S
T
I
V
I
L
N
--
R
I
E
A
----
G
E
-------
N
------
E
-
E
---
S
S
----
I
----
K
W
I
K
---
E
K
F
K
K
-----
D
--
G
F
L
------
V
--
A
T
Y
N
G
K
N
G
D
A
T
S
Q
--
I
E
S
P
S
I
Y
S
N
V
A
L
I
A
N
Y
-----
I
G
D
K
E
L
F
N
K
A
I
-
D
K
L
K
Y
Y
-
Q
I
K
N
K
D
S
V
L
Y
G
G
------
F
GD
E
K
--
T
N
S
V
Y
S
F
D
N
L
N
A
--
L
L
A
F
Q
K
--------------------------------
13
HHSearch
58.22
17%
-76
- C4 -
4Q2B
5
?
A:
[3-327]
---------------------------------------
A
W
P
A
--
W
E
R
F
-----
K
A
E
L
V
S
V
-
D
-----------
G
-
R
V
I
D
---
P
S
D
E
R
---------------
L
I
T
T
S
E
G
Q
S
Y
A
L
F
F
A
L
----
V
G
-----
N
D
R
Q
T
F
A
Q
L
L
R
W
T
S
N
N
L
--------
A
E
G-------
D
LA-
R
H
L
P
A
W
L
W
G
R
------
D
GQQQWQ
V
------
L
D
-
A
N
N
A
S
D
A
D
L
W
I
A
Y
----
S
L
L
E
A
G
R
L
W
D
Q
P
-----
A
Y
T
Q
L
G
Q
H
L
L
-
W
R
I
A
A
Q
T
V
--
R
--
K
LP--
G
L
G
V
------------------
M
L
------
L
P
G
----
D
--
Y
--
G
FED-
A
----------
Q
----------
G
T
R
L
N
P
S
Y
----
L
P
L
Q
L
-
L
-
D
R
F
------------
S
D
---
V
-----
D
------
P
L
W
G
-
E
L
A
A
N
T
R
R
---
L
W
L
A
-
S
----
S
--
P
K
----
G
-----
F
A
P
D
W
L
L
W
T
P
A---------
G
KPAADTKHGN
A
G
D
---
Y
--------------
D
A
I
R
V
Y
L
W
--
V
G
M
L
----
A
E
-------
G
AAQ---
R
-
R
---
E
L
V
A
H
Y
A
----
P
M
A
----
A
L
T
Q
R
-----
Q
--
G
L
P
------
P
--
E
H
L
D
A
R
S
G
E
A
R
-
G
--
H
G
P
A
G
F
S
A
A
L
L
P
L
L
A
A
-----
S
-
P
E
H
---
V
A
G
L
A
A
Q
R
Q
R
-
L
R
E
Q
P
--------------------
V
E
A
K
A
Y
Y
S
Q
V
L
A
--
L
F
G
Q
G
F
D
-------------------------------
9
HHSearch
56.38
19%
-56
- C4 -
1KWF
1
GUNA_CLOTH
A:
[20-352]
--------------------------------
Q
S
E
V
T
A
M
L
K
A
E
--
W
E
D
W
-----
K
S
K
R
I
T
S
-
N
-----------
G
A
G
G
Y
K
R
V
Q
R
D
A
S
T
------
N
--------
Y
D
T
V
S
Q
G
M
G
Y
G
L
L
L
A
V
----
C
F
-----
N
E
Q
A
L
F
D
D
L
Y
R
Y
V
K
S
H
F
--------
N
---------
G
---
N
G
L
M
H
W
H
I
D
A
------
N
------
N
NVTSHD
G
G
-
D
G
A
A
T
D
A
D
E
D
I
A
L
----
A
L
I
F
A
D
K
L
W
G
S
S
GAI--
N
Y
G
Q
E
A
R
T
L
I
-
N
N
L
Y
N
H
C
V
--
E
--
H
----
G
-
S
-------------------
Y
V
L-----
K
P
G
----
D
--
R
--
W
----
G
----------
G
----------
S
S
V
T
N
P
S
Y
----
F
A
P
A
W
-
Y
-
K
V
Y
------------
A
Q
---
Y
-----
T
GD----
T
R
W
N
-
Q
V
A
D
K
C
Y
Q
---
I
V
E
E
-
V
K
K
Y
-
N
N-
G
T
----
G
-----
L
V
P
D
W
C
T
A
S
G
TPASGQS---
Y
----------
D
Y
K
---
Y
--------------
D
A
T
R
Y
G
W
R
--
T
A
V
D
Y
S
W
F
G
D
-------
Q
------
R
-
A
K
--
A
N
----
C
----
D
M
L
T
---
K
F
F
A
R
-----
D
GA
K
G
I
------
V
--
D
G
Y
T
-
I
Q
G
S
K
I
S
N
--
N
H
N
A
S
F
I
G
P
V
A
A
A
S
M
T
-----
G
-
Y
D
L
N
F
A
K
E
L
Y
R
----
E
-
T
V
A
V
K
-----------------
D
--
S
E
Y
Y
G
Y
Y
G
N
S
L
R
--
L
L
T
L
L
Y
I
-------------------------------
11
HHSearch
55.12
16%
-78
- C4 -
1WU4
2
REOX_BACHD
A:
[24-372]
-------------------------------
S
E
A
E
I
Q
E
R
V
K
D
T
--
W
E
Q
L
FGDNP
K
I
Y
Y
E
V
G
D
D
L
----------
G
-
Y
L
L
D
---
T
-
G
--------
N
--------
L
D
V
R
T
E
G
M
S
Y
G
M
M
M
A
V
----
Q
M
-----
D
R
K
D
I
F
D
R
I
W
N
W
T
M
K
N
M
--------
Y
M
T-------
E
GVH
A
G
Y
F
A
W
S
C
Q
P
------
D
GT----
K
------
N
S
-
W
G
P
A
P
D
G
E
E
Y
F
A
L
----
A
L
F
F
A
S
H
R
W
G
D
G
DEQPF
N
Y
S
E
Q
A
R
K
L
L
-
H
T
C
V
H
N
G
E
--
G
--
G
----
P
-
G
-------------------
H
P
------
M
W
N
----
R
--
D
--
N
----
K
LIKFIP----
E
----------
V
E
F
S
D
P
S
Y
----
H
L
P
H
F
-
Y
-
E
L
F
------------
S
L
---
W
ANEED
R
------
V
F
W
K
-
E
A
A
E
A
S
R
E
---
Y
L
K
I
-
A
C
---
H
P-
E
T
----
G
-----
L
A
P
E
Y
A
Y
Y
D
G
----------
T
-----------
P
N
---
D
EKG
Y
---
G
-
H
F
F
-
S
D
S
Y
R
V
A
A
N
--
I
G
L
D
A
E
W
F
G
G
-------
S
E
W
S
A
E
E
I
-
N
---
K
I
----
Q
----
A
F
F
A
---
D
K
E
----------
P
E
D
------
Y
--
R
R
Y
K
-
I
D
G
E
P
F
E
E
KS
L
H
P
V
G
L
I
A
T
N
A
M
G
S
L
A
-----
S
-
V
D
G
P
Y
A
K
A
N
V
D
L
F
W
N
T
-
P
V
R
T
G
----------------------
N
R
R
Y
Y
D
N
C
L
Y
--
L
F
A
M
L
A
L
-------------------------------
14
HHSearch
54.08
16%
-78
- C4 -
1WZZ
1
GUNA_KOMHA
A:
[15-329]
-----------------------------------
A
P
D
A
V
A
Q
Q
--
W
A
I
F
-----
R
A
K
Y
L
R
P
-
S
-----------
G
-
R
V
V
D
---
T
G
N
--------
G
--------
G
E
S
H
S
E
G
Q
G
Y
G
M
L
F
A
A
----
S
A
-----
G
D
L
A
S
F
Q
S
M
W
M
W
A
R
T
N
L
--------
Q
H
T-------
N
---
D
K
L
F
S
W
R
F
L
K
------
G
HQPP--
V
------
P
D
-
K
N
N
A
T
D
G
D
L
L
I
A
L
----
A
L
G
R
A
G
K
R
F
Q
R
P
-----
D
Y
I
Q
D
A
M
A
I
Y
-
G
D
V
L
N
L
M
T
--
M
K
-
A
----
G
-
P
-------------------
Y
V
------
V
L
M
PGAV
G
--
F
--
T
K---
K
----------
D
----------
S
V
I
L
N
L
S
Y
----
Y
V
M
P
S
-
L
L
Q
A
F
------------
D
L
T--
A
-----
D
------
P
R
W
R
-
Q
V
M
E
D
G
I
R
---
L
V
S
A
-
G
R
---
F
G-
Q
W
----
R
-----
L
P
P
D
W
L
A
V
N
R
AT--------
G
----------
A
L
S
---
I
---
A
SGW
P
-
P
R
F
S
Y
D
A
I
R
V
P
L
Y
--
F
Y
W
A
----
H
M
-------
L
A
P
N
V
--
L
-
A
---
D
F
----
T
----
R
F
W
N
---
N
F
--
G
-----
A
--
N
A
L
------
P
--
G
W
V
D
L
T
T
G
A
-
R
S
P
--
Y
N
A
P
P
G
Y
L
A
V
A
E
---
C
-----
T
-
G
L
D
S
-----
A
G
E
---
L
-
P
T
L
----------------------
D
H
A
P
D
Y
Y
S
A
A
L
T
--
L
L
V
Y
I
A
R
-
A
-----------------------------
8
HHSearch
50.95
13%
-75
- C4 -
5CD2
4
?
A:
[25-352]
---------------------------------------
E
W
G
Q
--
W
E
S
F
-----
K
Q
H
Y
I
E
--
N
-----------
G
-
R
V
V
D
---
N
S
D
P
R
---------------
L
I
T
T
S
E
G
Q
S
Y
A
L
F
F
A
L
----
I
A
-----
N
D
K
K
T
F
D
E
L
L
G
W
T
E
L
H
L
--------
A
G
G-------
D
LT-
A
Q
L
P
A
W
L
W
G
T
QP----
D
GSQG--
I
------
L
D
-
S
N
S
A
A
D
S
D
L
W
I
A
Y
----
S
L
L
E
A
G
R
L
W
D
N
H
-----
Y
Y
Q
S
L
G
H
L
L
A
-
S
R
I
L
R
D
E
T
--
I
--
K
V
S
G-
L
-
G
-------------------
T
V
L
L
P---
G
K
V
----
G
--
F
--
V
LG--
K
----------
N
----------
H
V
R
L
N
P
S
Y
----
V
P
L
Q
L
-
L
-
T
R
M
------------
N
T
---
V
-----
F
PS----
Y
Q
W
E
-
E
I
Y
Q
S
S
A
K
---
L
L
K
E
-
T
M
------
P
K
----
G
-----
Y
S
P
D
W
V
E
W
D
K
TQFKKDSKAQ
S
----------
V
G
S
---
Y
--------------
N
A
I
R
V
Y
L
W
--
A
G
M
L
----
P
D
SD
P
N
K
A
L
L
------
L
-
G
---
K
M
----
K
----
P
L
L
----
R
V
I
E
R
-----
N
--
K
G
M
------
P
--
E
T
I
N
V
L
T
G
K
G
K
-
N
--
Q
G
G
V
G
M
N
A
A
I
L
P
L
L
S
S
-----
L
-
D
S
N
T
N
V
A
E
Y
E
K
K
I
Q
A
E
-
L
P
K
----------------------
I
E
S
D
Y
Y
Y
N
S
V
L
T
--
L
F
G
L
G
W
Y
-
Q
-----------------------------
10
HHSearch
50.35
16%
-57
- C4 -
1V5D
-
?
A:
[24-377]
--------------------------------
Q
E
S
L
N
A
S
V
R
S
Y
--
Y
D
N
W
-----
K
K
K
Y
L
K
N
-
D
LSSLPG
G
Y
Y
V
K
G
-
E
I
T
G
---
D
A
D
G
F
------
K
--------
P
L
G
T
S
E
G
Q
G
Y
G
M
I
I
T
V
----
L
M
AGYDS
N
A
Q
K
I
Y
D
G
L
F
K
T
A
R
T
F
K
--------
S
S
Q-------
N
---
P
N
L
M
G
W
V
V
A
D
------
S
------
K
KAQ---
G
H
-
F
D
S
A
T
D
G
D
L
D
I
A
Y
----
S
L
L
L
A
H
K
Q
W
G
S
N
GTV--
N
Y
L
K
E
A
Q
D
M
I
T
K
G
I
K
A
S
N
V
--
T
--
N
----
N
-
N
-------------------
Q
L
------
N
L
G
----
D
--
W
--
D
----
S
K---------
S
----------
S
L
D
T
R
P
S
D
----
W
M
M
S
H
-
L
-
R
A
F
------------
Y
E
---
F
-----
T
GD----
K
T
W
L
-
T
V
I
N
N
L
Y
D
---
V
Y
T
Q
-
F
S
N
K
Y
S
P-
N
T
----
G
-----
L
I
S
D
F
V
V
K
N
P
PQPAP-----
K
----------
D
F
L
---
D
ESE
Y
---
T
-
N
A
Y
Y
Y
N
A
S
R
V
P
L
R
--
I
V
M
D
Y
A
M
Y
G
E
-------
K
R
S
K
V
I
-
S
-
D
---
K
V
----
S
----
S
W
I
Q
---
N
K
T
N
G
-----
N
P-
S
K
I
------
V
--
D
G
Y
Q
-
L
N
G
S
N
I
G
S
--
Y
P
T
A
V
F
V
S
P
F
I
A
A
S
I
T
-----
S
----
S
N
N
Q
K
W
V
N
S
G
W
D
W
-
M
-
K
N
K
----------------------
R
E
R
Y
F
S
D
S
Y
N
--
L
L
T
M
L
F
I
-------------------------------
12
HHSearch
49.95
15%
-55
- C4 -
3QXF
-
GUN_ECOLI
A:
[24-344]
---------------------------------------
T
W
P
A
--
W
E
Q
F
-----
K
K
D
Y
I
S
Q
-
E
-----------
G
-
R
V
I
D
---
P
S
D
A
R
---------------
K
I
T
T
S
E
G
Q
S
Y
G
M
F
S
A
L
----
A
A
-----
N
D
R
A
A
F
D
N
I
L
D
W
T
Q
N
N
L
--------
A
Q
G-------
S
LK-
E
R
L
P
A
W
L
W
G
K
------
K
ENSKWE
V
------
L
D
-
S
N
S
A
S
D
G
D
V
W
M
A
W
----
S
L
L
E
A
G
R
L
W
K
E
Q
-----
R
Y
T
D
I
G
S
A
L
L
-
K
R
I
A
R
E
E
V
--
V
--
T
V
PGL
G
-
S
-------------------
M
L
L
P----
G
K
V
----
G
--
F
--
A
E---
D
----------
N
----------
S
W
R
F
N
P
S
Y
----
L
P
P
T
L
-
A
-
Q
Y
F
------------
T
R
---
F
-----
G
------
A
P
W
T
-
T
L
R
E
T
N
Q
R
---
L
L
L
E
-
T
A
------
P
K
----
G
-----
F
S
P
D
W
V
R
Y
E
K
----------
D
K---------
G
W
Q
---
L
KAE
K
---
T
-
L
I
S
S
Y
D
A
I
R
V
Y
M
W
--
V
G
M
M
----
P
D
-------
S
------
D
-
P
Q
K
A
R
M
----
L
----
N
R
F
K
P
M
A
T
F
T
E
K
-----
N
--
G
Y
P
------
P
--
E
K
V
D
V
A
T
G
K
A
Q
G
---
K
G
P
V
G
F
S
A
A
M
L
P
F
L
Q
------
N
-
R
D
----
A
Q
A
V
Q
R
Q
R
V
A
-
D
N
F
----------------------
P
G
S
D
A
Y
Y
N
Y
V
L
T
--
L
F
G
Q
G
W
D
-------------------------------
33
Fugue
47.93
17%
-82
- C3 -
4MND
4
DIPPS_ARCFU
A:
[40-457]
---
L
M
K
A
V
I
L
A
---
A
G
L
G
G
G
V
P
K
P
L
V
R
V
G
G
C
E
I
I
L
R
T
M
K
L
L
S
P
HV
S
E
F
I
-----
I
V
A
S
--------------------------
R
Y
A
D
------
D
--------
I
D
A
F
L
K
D
K
G
F
N
Y
K
I
V
R
H
DRP
E
K
-----
G
N
G
Y
S
L
L
V
A
K
N
H
V
E
D
R
F
--------
I
L
--------
T
M
G-
D
H
V
Y
S
Q
Q
F
I
E
------
K
------
A
------
V
R
-
G
E
G
V
I
A
D
R
E
P
R
F
V
----
D
I
G
E
A
T
-
K
I
R
V
E
-----
D
--
G
R
V
A
K
I
G
-
K
D
L
R
E
F
D
C
--
V
--
D
T---
G
-
F
-------------------
F
V
L
D
D
S
I
F
E
H
A
----
E
--
K
--
L
----
R
----------
D
----------
R
E
E
I
P
L
S
E
----
I
V
K
L
A
R
L
-
P
V
T
------------
Y
V
---
D
-----
G
E
L
W
M
--
D
V
D
T
-
K
E
D
V
R
R
A
N
R
--
A
L
V
S
-
A
A
---
V
--
G
D
----
G
-----
F
I
S
R
K
I
N
R
K
I
----------
S
----------
T
R
I
---
S
---
A
---
A
-
I
V
N
K
V
N
P
N
Q
M
T
L
I
--
S
F
L
V
----
G
A
-------
F
------
S
-
A
---
L
A
----
S
FFS
I
P
L
A
G
---
L
L
Y
Q
F
-----
S
--
S
I
L
D
G
C
D
G
E
I
--
A
R
A
S
L
K
M
S
K
K
G
G
Y
--
V
D
S
I
L
D
R
F
V
D
F
L
F
L
A
I
I
A
L
L
Y
P
K
T
A
T
V
A
M
F
A
I
F
G
S
V
M
V
S
-
Y
T
S
E
K
Y
K
A
E
F
G
E
SIRVLN
Y
--
I
P
--
G
K
R
D
E
R
I
F
L
I
M
I
--
F
C
L
L
S
A
I
-
S
L
Q
W
I
F
W
M
F
L
F
V
A
A
I
S
L
T
R
V
V
V
T
L
L
A
V
L
V
S
36
Fugue
47.87
17%
-49
- C2 -
4JY3
7
?
A:
[10-379]
K
T
R
R
A
E
V
A
G
G
G
F
A
G
L
T
A
A
I
A
L
K
Q
N
G
W
D
V
R
L
H
E
K
S
S
-
E
L
R
A
F
G
A
--
G
I
Y
L
-----
W
H
N
G
L
R
V
-
L
-----------
E
-
G
L
G
A
---
L
D
D
V
L
------
Q
--------
G
S
H
T
P
P
T
Y
E
T
W
M
---------------
H
N
K
S
V
S
K
E
T
F
N
G
L
P
W
R
I
--------
M
T
--------
R
---
S
H
L
H
D
A
L
V
N
R
------
A
------
R
------
A
L
-
G
V
D
I
S
V
N
S
E
A
V
A
A
D
PV
G
R
L
T
L
Q
T
G
E
V
L
E
A
-----
D
L
I
V
G
A
D
G
V
G
-
S
K
V
R
D
S
I
-----------------------------------------
G
F
K
----
Q
--
D
--
R
----
W
----------
V
----------
S
K
D
G
L
I
R
L
----
I
V
P
R
M
-
K
-
K
E
L
------------
G
H
GEW
D
-----
N
------
T
I
D
M
W
N
F
W
P
R
V
Q
R
---
I
L
Y
S
-
P
C
---
N
--
E
N
E
L
Y
L
G
-----
L
M
A
P
A
A
D
P
R
G
----------
S
----------
S
V
P
---
I
---
D
---
L
-
E
V
W
V
E
M
F
P
F
L
E
P
C
--
L
I
E
A
----
A
K
-------
L
------
K
-
T
---------
A
----
R
Y
D
K
---
Y
E
T
T
K
L
DSWT
R
--
G
K
V
------
A
L
V
G
-
D
A
A
H
A
M
C
P
A
L
A
--
Q
G
A
G
C
A
M
V
N
A
F
S
L
S
Q
D
-----
L
E
E
G
S
S
V
E
D
A
L
V
A
W
E
T
R
I
R
P
I
T
D
R
C
Q
A
L
S
G
D
------
Y
--
A
A
--
N
R
S
L
S
K
G
N
M
F
T
P
AA
L
E
A
A
R
Y
D
-
P
L
R
R
V
Y
S
WPQ--------------------
15
HHSearch
47.79
14%
-51
- C4 -
1H12
1
?
A:
[54-399]
-----------------------------------------
T
E
--
N
G
V
Y
-----
K
A
H
Y
I
K
-----------------
A
I
N
---
P
D
E
--------
G
--------
D
D
I
R
T
E
G
Q
S
W
G
M
T
A
A
V
----
M
L
-----
N
K
Q
E
E
F
D
N
L
W
R
F
A
K
A
Y
Q
--------
K
N
PDNHPDAK
K
---
Q
G
V
Y
A
W
K
L
K
L
------
N
------
Q
NG
F
V
Y
K
V
D
-
E
G
P
A
P
D
G
E
E
Y
F
A
F
----
A
L
L
N
A
S
A
R
W
G
N
S
GEF--
N
Y
Y
N
D
A
I
T
M
L
-
N
T
I
K
N
K
L
M
--
E
--
N
----
Q
---------------------
I
I
------
R
F
S
----
P
--
Y
--
I
--------------------------
D
N
L
T
D
P
S
Y
----
H
I
P
A
F
-
Y
-
D
Y
F
------------
A
N
---
N
-----
V
TN
Q
A
D
K
N
Y
W
R
-
Q
V
A
T
K
S
R
T
---
L
L
K
N
-
H
F
---
T
K
-
V
S
----
G
SPHWN
L
P
T
F
L
S
R
L
D
G
----------
S
PVIGY-----
I
F
N
GQA
N
---
P
---
G
-
Q
W
Y
E
F
D
A
W
R
V
I
M
N
--
V
G
L
D
A
H
L
M
G
A
-------
Q
A
W
H
K
S
A
V
-
N
---
K
A
----
L
----
G
F
L
S
---
Y
A
K
T
N
-----
N
SK
N
C
Y
------
E
--
Q
V
Y
S
-
Y
G
G
A
Q
N
R
G
--
C
A
G
E
G
Q
K
A
A
N
A
V
A
L
L
A
-----
S
-
T
N
A
G
Q
A
N
E
F
F
N
E
F
W
S
L
-
S
Q
P
T
G
----------------------
D
Y
R
Y
Y
N
G
S
L
Y
--
M
L
A
M
L
H
V
S
G
N
F
K
F
-------------------------
21
HHSearch
45.91
14%
-120
- C4 -
3WKG
2
CEEP_RHOMR
A:
[86-244]
--------------------------------------------------------------------------------------------------------------------------------------
M
A
E
R
A
Y
R
Y
F
V
R
H
F
--------
V
D
--------
A
E--
H
G
G
V
Y
W
M
V
A
A
------
D
GR----
P
------
L
D
-
T
R
K
H
V
Y
A
Q
S
F
A
I
Y
----
A
L
S
E
W
H
R
A
T
G
G
E
-----
A
A
L
A
L
A
R
S
I
Y
-
D
L
I
E
T
H
C
A
--
D
RV
H
----
G
-
G
-------------------
Y
V
------
E
A
C
----
D
RA
W
--
R
----
P
LE--------
D
ARLSAKDAPE
P
R
S
M
N
T
H
L
----
H
V
L
E
A
-
Y
-
A
N
L
------------
Y
R
---
V
-----
W
PE----
T
E
L
A
-
A
R
L
Q
A
L
I
E
---
L
F
L
R
-
A
I
---
Y
HP
A
T
----
G
-----
H
L
I
L
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
44.53
10%
-100
- C4 -
2SQC
4
SQHC_ALIAD
A:
[37-307]
L
S
N
V
T
M
E
A
E
Y
V
L
L
C
H
I
L
D
----------------
R
V
D
R
D
R
M
E
K
--
I
R
R
Y
-----
L
L
H
E
Q
R
E
-
D
-----------
G
-
T
W
A
L
---
Y
P
G
G
P
------
P
--------
D
L
D
T
T
I
E
A
Y
V
A
L
K
Y
I
G
----
M
S
-----
R
D
E
E
P
M
Q
K
A
L
R
F
I
Q
S
Q
------------------------------------------------------
G
-
G
I
E
S
S
R
V
F
T
R
M
W
L
----
A
L
------
V
G
E
Y
-----
P
W
E
K
V
P
---
M
-
V
P
P
E
I
M
F
L
--
G
--
K
----
R
-
M
-------------------
P
L
------
N
I
Y
----
E
--
F
--
G
----
S
----------
W
----------
A
R
A
T
V
V
A
L
----
S
I
V
M
S
-
R
-
Q
P
V
------------
F
P
---
L
------------------
P
E
R
A
R
V
P
---
E
L
Y
E
-
T
D
---
V
--
P
-------------
P
R
R
R
G
A
K
G
----------
G
----------
G
G
W
---
I
---
F
---
D
-
A
L
D
R
A
L
H
G
Y
Q
K
L
S
--
V
H
P
F
----
R
R
-------
A
------
A
E
I
---
R
A
----
L
----
D
W
L
L
---
E
R
Q
A
G
-----
D
--
G
S
W
------
G
--
G
I
---------------
Q
P
P
W
F
Y
A
L
I
A
L
K
I
L
-----
D
M
T
Q
H
P
A
F
I
K
G
W
E
G
L
E
L
Y
-
G
V
E
L
D
----
Y
G
G
------
W
--
M
F
--
Q
A
S
-------------------------------------------------
18
HHSearch
43.31
9%
-103
- C4 -
3WKG
3
CEEP_RHOMR
A:
[19-159]
----------------------------------------------------------------------------------------------------------------------------------
V
H
E
E
L
T
E
N
I
L
K
F
W
A
T
R
T
--------
H
D
P-------
V
---
H
G
G
F
V
G
R
V
G
P
------
D
GR----
P
------
H
P
E
A
P
R
G
A
I
L
N
A
R
I
L
W
----
T
F
A
A
A
Y
R
Q
L
G
T
P
-----
L
Y
R
E
M
A
E
R
A
Y
-
R
Y
F
V
R
H
F
V
--
D
--
A
EH--
G
-
G
-------------------
V
Y
------
W
M
V
----
A
--
A
--
D
----
G
----------
R
----------
P
L
D
T
R
K
H
V
Y
A
Q
S
F
A
I
Y
A
-
L
-
S
E
W
------------
H
R
---
A
-----
T
GG----
E
A
A
L
-
A
L
A
R
S
I
Y
D
---
L
I
E
T
-
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.40
52%
-101
- C5 -
2Z4T
2
?
A:
[198-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
--
S
N
T
A
H
S
F
D
N
L
V
P
--
I
L
K
E
L
N
S
-
F
N
----------------------------
31
Fugue
35.36
11%
-38
- C4 -
1H12
1
?
A:
[1-403]
A
F
N
N
N
P
S
S
V
G
A
Y
S
S
G
T
Y
R
N
L
A
Q
E
M
G
K
T
N
I
Q
Q
K
V
N
S
T
F
D
N
M
F
G
Y
--
N
N
T
Q
-----
Q
L
Y
Y
P
Y
T
-
E
-----------
N
-
G
V
Y
K
---
A
H
Y
I
K
AINPDE
G
--------
D
D
I
R
T
E
G
Q
S
W
G
M
T
A
A
V
----
M
L
-----
N
K
Q
E
E
F
D
N
L
W
R
F
A
K
A
Y
Q
KNPDNHPD
A
K
--------
K
---
Q
G
V
Y
A
W
K
L
K
L
N
QNG
F
V
Y
------
K
------
V
D
-
E
G
P
A
P
D
G
E
E
Y
F
A
F
----
A
L
L
N
A
S
A
R
W
G
N
S
GEF--
N
Y
Y
N
D
A
I
T
M
L
-
N
T
I
K
N
K
L
M
--
E
--
N
----
Q
-
I
IRFSPYIDNLTDPSYHI
P
A
F
Y
------
D
Y
F
----
A
--
N
N
V
T
----
N
----------
Q
----------
A
D
K
N
Y
W
R
Q
----
V
A
T
K
S
-
R
-
T
L
L
------------
K
N
---
H
-----
F
------
T
K
V
S
-
G
S
P
H
W
N
L
P
TFL
S
R
L
D
-
G
S
---
P
--
V
I
----
G
-----
Y
I
F
N
G
Q
A
N
P
G
----------
Q
----------
W
Y
E
---
F
---
D
---
A
W
R
V
I
M
N
V
G
L
D
A
H
L
M
GA
Q
A
W
H
----
K
S
-------
A
------
V
-
N
---
K
A
----
L
----
G
F
L
S
---
Y
A
K
T
N
-----
N
--
S
K
N
------
C
--
Y
E
Q
V
Y
S
Y
G
G
A
Q
N
R
--
G
C
A
G
E
G
Q
K
A
A
N
A
V
A
L
L
-----
A
S
T
N
A
G
Q
A
N
E
F
F
N
E
F
W
S
L
-
S
Q
P
T
G
D
Y
R
Y
Y
N
G
------
S
--
L
Y
--
M
L
A
M
L
H
V
S
G
N
F
K
--
F
Y
N
N
T
---------------------------------
23
HHSearch
34.40
12%
-92
- C4 -
4WU0
-
?
A:
[42-181]
----------------------------------------------------------------------------------------------------------------------------------
K
D
K
K
Y
L
D
F
I
I
K
T
M
D
-
T
F
--------
I
N
E-------
D
---
G
T
I
N
G
Y
K
L
E
--------------------------
E
Y
N
I
D
H
L
N
N
G
K
----
I
L
I
T
L
F
K
E
T
G
K
E
-----
K
Y
R
K
A
L
I
N
L
R
-
K
Q
I
D
N
H
P
R
--
T
--
K
E---
N
-
V
-------------------
F
W
------
H
K
N
----
I
--
Y
-------
P
----------
H
----------
Q
I
W
L
D
G
L
Y
----
M
G
A
T
F
-
Y
-
A
K
Y
------------
V
K
---
E
-----
F
GE----
E
K
E
F
-
D
D
I
T
H
Q
F
I
---
I
T
E
K
-
N
L
---
K
DN
K
T
----
G
-----
L
L
Y
H
A
Y
D
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
32.71
11%
-93
- C4 -
3VW5
-
CEEP_RUMAL
A:
[71-229]
-------------------------------------------------------------------------------------------------------------------------------------
D
N
A
K
H
A
Y
E
F
I
K
N
N
C
--------
I
D
Y-------
E
---
Y
G
G
V
Y
W
M
M
D
F
------
E
GK----
P
------
A
D
-
T
M
K
H
T
Y
N
I
A
F
A
I
Y
----
A
L
S
S
Y
Y
R
A
S
G
D
K
-----
E
A
L
A
L
A
Y
R
L
F
-
E
D
I
E
K
N
T
L
--
Y
--
E
----
Y
-
G
-------------------
Y
R
------
E
A
F
----
D
--
R
--
Q
WRLV
D
NEALSENGLK
A
----------
D
K
T
M
N
A
I
L
----
H
L
I
E
A
-
Y
-
T
E
L
------------
Y
K
---
A
-----
D
GN----
E
K
V
A
-
D
R
L
K
F
Q
L
G
---
Q
M
R
D
-
I
V
---
Y
TP
D
T
----
N
-----
A
L
K
V
F
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
31.66
12%
-100
- C4 -
3PMM
5
?
A:
[110-220]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
T
M
A
P
F
L
----
T
L
A
Y
R
F
E
E
T
G
R
M
-----
A
Y
L
P
W
L
E
S
W
A
-
E
W
A
M
H
E
M
P
RT
E
--
Q
----
G
-
G
-------------------
M
Q
------
H
M
T
----
L
--
A
EE
N
----
H
----------
Q
----------
Q
M
W
D
D
T
L
M
----
M
T
V
L
P
-
L
-
A
K
I
------------
G
K
---
L
-----
L
NR----
P
Q
Y
V
-
E
E
A
T
Y
Q
F
L
---
L
H
V
Q
N
L
M
---
D
R-
E
T
----
G
-----
L
W
F
H
G
W
N
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------