@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04520: (2016-06-07 )
MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQKLRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNSWDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTTMSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVMLDENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNVPAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDKAMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES
Atome Classification :
(20 SA)
------.....--------------....10........20..-...-----...30...---------------.....---40........50........60...-.---....70........80..-.-.--....90.----------------------.-------.-.....100.--...---...110.......-120.-......130..-----..-....140...--.-...--150.......160.....--..170..---.---.--------.-------..---180-..-----.---.----.....---190.......200...--....210......-.-220...-..-...-230.-------.--..--....-------240.......250.......260.......270.......280.......----290.......300--------.....-----...310.......-320.......330.......340.......350.......360.......370.......380-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------M
S
L
F
I--------------QN
D
Q
Q
R
Q
W
M
E
K
I
G
R
I
A
D
E
-
F
Q
Q
-----
T
AAEDDEQ---------------GRF
P
A
---
E
K
I
Q
K
L
R
DAG
Y
T
A
L
T
L
PASHGGG
G
I
-
S
---
V
Y
D
M
L
L
F
Q
E
R
LARGDAP
T
-
A
-
L
--
S
I
G
W
H
L
S
----------------------
V
-------
I
-GELGEGNSW--
D
E
D
---
V
F
A
F
V
A
K
E
VQNG
A
-
V
I
NR-AATEAKT-GSP-----TR-GGRPGTHAVK--K-D
G
K
--
W
A
VNGR
K
T
F
T
T
M
S
Q
A
L
D
Y
--
F
L
V
T
A
W
I---E---D--------K-------QT---T---
G
V
-----
F
---
L
----
I
HKDD---PGL
S
I
E
E
T
W
D
M
M
A
M
RA--TGSH
D
L
V
L
N
E
V
ML-
D
-
E
-
N
K
L
V
-
E
L
-
L
QG-P-RG-------A--KP--N
G
W
L
-------
L
H
I
P
A
I
Y
L
G
V
A
Q
A
A
R
D
Y
A
V
Q
F
A
SEYSPNSLNGPIKNVP
A
V
Q
Q
RTGEM
E
L
E
----
L
L
NA
R
H
F
L
F
H
I
A
---------
Q
L
YDD-----PVRRPH
L
T
S
E
LG
A
-
A
K
H
I
V
T
N
A
A
L
S
V
V
D
K
A
M
R
I
V
G
AKSLERT
N
P
L
Q
R
Y
Y
R
D
V
R
AGLHNPPM
D
D
A
V
I
H
K
L
A
A
E
A
FES------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.40
29%
-96
- C1 -
3MXL
-
?
A:
[14-372]
------------------------------
R
T
V
V
D
L
L
A
G
V
I
P
R
-
I
S
A
-----
E
A
A
D
R
D
R
T
---------------
G
T
F
P
V
---
E
A
F
E
Q
F
A
K
L
G
L
M
G
A
T
V
P
A
E
L
G
G
L
G
L
-
T
R--
L
Y
D
V
A
T
A
L
M
R
L
A
E
A
D
A
S
T
-
A
-
L
--
A
--
W
H
V
Q
----------------------
L
-------
S
-
R
G
L
T
L
T
Y
E
W
--
Q
H
G
T
P
P
V
R
A
M
A
E
R
L
L
R
A
M
A
-
E
G
E
A
-
A
V
C
G
A
L
K
-
D
A
P
--------
G
V
V
T
E
L
H
S
-
D
--
G
-
A
G
G
--
W
L
L
S
G
R
K
V
L
V
S
M
A
P
I
A
T
H
--
F
F
V
H
A
Q
R
---
R
---
D
--------
D
-------
D
G
---
S
----
V
-----
F
---
L
A
V
P
V
V
H
R
D
A
---
P
G
L
T
V
L
D
N
W
D
G
L
G
M
R
A
--
S
G
T
L
E
V
V
F
D
R
C
P
V
-
R
-
A
-
D
E
L
L
-
E
---
R
G
-
P
-
V
G
-------
A
--
R
R
--
D
A
V
L
A
G
Q
T
V
S
S
I
T
M
L
G
I
Y
A
G
I
A
Q
A
A
R
D
I
A
V
G
F
C
A
G
R
G
G
E
P
R
A
G
A
R
A
L
V
A
G
L
D
T
R
L
Y
A
L
R
T
T
V
G
A
A
L
T
N
A
D
A
A
S
V
D
L
S
---------
G
D
P
D
E
-----
R
G
R
R
--
M
M
T
P
F
Q
Y
-
A
K
M
T
V
N
E
L
A
P
A
V
V
D
D
C
L
S
L
V
G
G
L
A
Y
T
A
G
H
P
L
S
R
L
Y
R
D
V
R
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.58
23%
-118
- C1 -
4ZXV
-
?
A:
[27-383]
------------------------------
R
R
L
L
D
L
L
E
R
Y
L
P
A
-
L
E
A
-----
E
S
R
D
N
D
R
E
---------------
A
T
L
P
V
---
H
L
F
D
R
M
R
K
E
G
V
L
G
A
T
V
P
E
D
L
G
G
L
G
V
H
S
---
L
H
D
V
A
L
A
L
A
R
I
A
G
R
D
A
G
V
-
A
-
L
--
A
L
H
M
Q
F
S
R
G
L
T
L
D
F
E
W
R
HGAPST
R
P
L
A
E
D
L
-------
L
-
R
Q
M
G
A
G
------
E
A
---
V
I
C
G
A
V
K
D
V
R
G
T
T
-
V
L
T
R
-
A
------------------------------
T
-
D
G
S
--
Y
R
L
N
G
R
K
T
L
V
S
M
A
G
I
A
T
H
--
Y
V
V
S
T
R
L
---
E
---
E
--------
A
---------
P
V
R
L
---
A
A
-----
P
---
V
----
V
A
R
T
T
---
P
G
L
T
V
L
D
N
W
D
G
M
G
M
R
S
--
S
G
S
V
D
I
V
F
D
G
C
P
V
-
D
-
R
-
D
R
V
---
L
-
P
R
G
-
E
-
P
G
-------
V
--
R
D
--
D
A
A
L
A
G
Q
T
V
S
S
I
A
M
L
G
I
Y
V
G
I
A
E
A
A
R
R
I
A
L
T
E
L
R
R
R
G
---------
G
A
P
A
G
V
R
T
T
----
V
A
----
E
I
D
A
R
L
F
A
L
H
T
A
V
A
S
A
L
T
T
A
D
R
L
A
D
D
LSGD
L
A
A
R
G
R
A
M
M
T
P
F
Q
Y
-
A
K
L
L
V
N
R
H
S
V
G
V
V
D
D
C
L
M
L
V
G
G
A
G
Y
S
N
S
H
P
L
A
R
L
Y
R
D
V
R
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.79
25%
-77
- C1 -
1UKW
2
?
A:
[3-356]
---------
F
S
--------------
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
-----
V
A
Q
E
Y
D
E
K
---------------
E
E
V
P
W
---
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
-
K
---
M
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
I
Y
T
-
I
--
P
M
A
S
D
L
G
----------------------
I
-------
T
-
P
V
L
L
A
G
T
----
E
E
Q
---
K
E
R
F
L
R
P
L
T
E
K
P
A
-
L
A
A
F
-
A
L
S
E
P
G
N
-
G
S
D
-----
A
A
-
A
L
K
--
T
R
A
I
R
--
Q
-
G
D
H
--
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
--
V
V
V
F
A
T
V
---
N
P--
E
--------
L
-------
R
H
---
K
---
G
V
V
A
---
L
---
V
----
V
E
R
G
T
---
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
--
S
G
T
Y
E
L
V
F
E
D
V
K
V
-
P
V
E
-
N
R
L
G
-
E
E
-
G
E
G
-
F
-
K
I
-------
A
--
M
Q
T
L
N
K
T
R
-------
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
--
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
----
I
E
T
A
R
M
Y
T
Y
Y
A
A
---------
W
L
A
D
Q
-----
G
L
P
H
A
H
A
S
A
---
I
-
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.39
21%
-75
* C1 *
2JIF
9
ACDSB_HUMAN
A:
[24-402]
------
A
P
L
Q
T
--------------
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
-----
L
V
S
T
M
D
E
N
---------------
S
K
M
E
K
---
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
-
S
---
F
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
-
A
-
V
--
F
C
E
I
Q
N
T
----------------------
L
-------
I
-
N
T
-
L
I
R
K
H
G
--
T
E
E
---
Q
K
A
T
Y
L
P
Q
L
T
T
E
K
-
V
G
S
F
-
C
L
S
E
A
G
A
-
G
S
D
-----
S
F
-
A
--
L
K
T
R
A
D
K
--
E
-
G
D
Y
--
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
--
F
L
V
M
A
N
V
---
D
---
P
--------
T
IGY----
K
G
---
I
---
T
S
-----
F
---
L
----
V
D
R
D
T
---
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
--
S
S
T
C
P
L
T
F
E
N
V
K
V
-
P
-
E
-
A
N
I
L
-
G
Q
-
I
G
H
-
G
Y
K
Y
A
I
-----
G
--
S
L
--
N
E
G
R
-------
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
--
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
----
L
E
A
A
R
L
L
T
Y
N
A
A
---------
R
L
L
E
A
-----
G
K
---
P
F
I
K
E
A
S
M
-
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.33
23%
-120
- C1 -
4ZYJ
1
?
A:
[47-403]
------------------------------
R
R
L
L
D
L
L
E
R
Y
L
P
A
-
L
E
A
-----
E
S
R
D
N
D
R
E
---------------
A
T
L
P
V
---
H
L
F
D
R
M
R
K
E
G
V
L
G
A
T
V
P
E
D
L
G
G
L
G
V
H
S
---
L
H
D
V
A
L
A
L
A
R
I
A
G
R
D
A
G
V
-
A
-
L
--
A
L
H
M
Q
F
S
R
G
L
T
L
D
F
E
W
R
HGAPST
R
P
L
A
E
D
L
-------
L
-
R
Q
M
G
A
G
------
E
A
---
V
I
C
G
A
V
K
D
V
R
G
T
T
-
V
L
T
R
----------------------------------
D
G
S
--
Y
R
L
N
G
R
K
T
L
V
S
M
A
G
I
A
T
H
--
Y
V
V
S
T
R
L
---
E
---
E
--------
A
---------
P
V
R
L
---
A
A
-----
P
---
V
----
V
A
R
T
T
---
P
G
L
T
V
L
D
N
W
D
G
M
G
M
R
S
--
S
G
S
V
D
I
V
F
D
G
C
P
V
-
D
-
R
-
D
R
V
---
L
-
P
R
G
-
E
-
P
------------
D
--
D
A
A
L
A
G
Q
T
V
S
S
I
A
M
L
G
I
Y
V
G
I
A
E
A
A
R
R
I
A
L
T
E
L
R
R
R
G
---------
G
A
P
A
G
V
R
T
T
----
V
A
----
E
I
D
A
R
L
F
A
L
H
T
A
V
A
S
A
L
T
T
A
D
R
L
A
D
D
LSGD
L
A
A
R
G
R
A
M
M
T
P
F
Q
Y
-
A
K
L
L
V
N
R
H
S
V
G
V
V
D
D
C
L
M
L
V
G
G
A
G
Y
S
N
S
H
P
L
A
R
L
Y
R
D
V
R
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
72.96
21%
-81
- C1 -
2EBA
3
?
A:
[7-381]
-------
L
E
D
L
--------------
L
T
P
E
E
K
E
V
Q
K
A
A
R
R
F
L
E
K
E
A
L
P
-----
H
I
R
D
W
W
E
E
---------------
G
V
F
P
T
---
H
L
I
P
R
F
A
E
L
G
F
L
G
P
T
L
P
P
E
Y
G
G
A
G
V
-
S
---
S
A
A
Y
G
L
I
C
Y
E
L
E
R
V
D
S
G
L
-
R
-
S
--
F
V
S
V
Q
S
S
----------------------
L
-------
V
-
M
Y
-
P
I
Y
A
Y
G
--
S
E
E
---
Q
K
R
E
F
L
P
K
L
A
R
G
E
M
V
G
C
F
-
G
L
T
E
P
D
G
-
G
S
D
-----
P
Y
G
N
--
M
K
T
R
A
R
R
-----
D
T
--
W
V
L
N
G
T
K
M
W
I
T
N
G
N
L
A
H
L
--
A
V
I
W
A
K
D
-------------------------
E
---
V
---
L
G
-----
F
---
L
----
V
P
T
D
T
---
P
G
F
Q
A
R
E
V
K
R
K
M
S
L
R
A
--
S
V
T
S
E
L
V
L
E
E
V
R
V
-
P
-
E
-
S
L
R
L
-
P
K
-
A
-
L
-
G
L
K
A
P
L
-----
S
--
C
L
--
T
Q
A
R
-------
F
G
I
A
W
G
A
M
G
A
L
E
A
V
Y
E
E
A
V
A
F
A
K
S
R
S
T
--
F
G
E
P
L
A
K
K
Q
L
V
Q
A
K
L
A
E
M
L
A
W
----
H
T
E
G
L
L
L
A
W
R
L
A
---------
R
L
K
D
E
-----
G
K
---
L
T
P
A
Q
V
S
L
-
A
K
R
Q
N
V
W
K
A
L
Q
A
A
R
M
A
R
D
I
L
G
G
S
G
I
T
L
E
Y
H
A
I
R
H
M
L
N
L
E
T
V
Y
T
Y
E
G
T
H
D
V
H
T
L
V
L
G
R
E
I
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
72.62
21%
-70
- C1 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
-------
M
D
F
N
--------------
L
T
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
-----
T
V
T
E
R
D
H
K
---------------
G
I
Y
D
K
---
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
-
D
GGD
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
V
-
A
-
I
--
T
L
S
A
T
V
S
----------------------
L
-------
C
-
A
N
P
I
W
Q
F
G
T
--
E
A
Q
---
K
E
K
F
L
V
P
L
V
E
G
T
K
-
L
G
A
F
-
G
L
T
E
P
N
A
-
G
T
D
-----
A
S
-
G
Q
Q
--
T
I
A
T
K
--
N
D
D
G
T
--
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
--
Y
I
V
F
A
M
T
DKS
K
---
G
--------
N
-------
H
G
---
I
---
T
A
-----
F
---
I
----
L
E
D
G
T
---
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
--
S
Q
T
M
E
L
V
F
Q
D
V
K
V
-
P
-
A
-
E
N
M
L
G
E
E
-
G
K
G
-
F
-
K
I
-------
A
--
M
M
T
L
D
G
G
R
-------
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
--
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
----
I
E
A
A
R
N
L
V
Y
K
A
A
---------
C
K
K
Q
E
--------
G
K
P
F
T
V
D
A
A
I
-
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
72.43
25%
-64
- C1 -
2D29
2
?
A:
[2-386]
------
G
L
W
F
E
--------------
E
G
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
-----
G
A
A
E
R
D
R
T
---------------
G
A
F
P
W
---
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
-
S
---
T
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
L
-
A
-
L
--
T
V
A
S
H
N
S
----------------------
L
-------
A
-
T
G
-
H
I
L
L
A
G
--
S
E
A
---
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
-
G
L
T
E
P
G
S
-
G
S
D
-----
A
A
-
A
--
L
K
T
K
A
E
K
--
V
-
E
G
G
--
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
--
Y
V
V
M
A
R
T
---
D
---
P
--------
P
PSPERKH
Q
G
---
I
---
S
A
-----
F
---
A
----
F
F
R
P
E
---
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
--
S
D
T
A
Q
L
I
L
E
D
L
F
V
-
P
-
E
-
E
A
L
L
-
G
E
-
R
G
K
-
G
F
Y
D
V
L
-----
R
--
V
L
--
D
G
G
R
-------
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
--
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
----
L
E
A
A
R
L
L
Y
L
K
A
A
---------
E
L
K
D
A
-----
G
R
---
P
F
T
L
E
A
A
Q
-
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
71.75
18%
-76
- C1 -
2UXW
4
ACADV_HUMAN
A:
[21-607]
QSMS
F
A
V
G
M
F
K
GQLTTDQVFPYPSV
L
N
E
E
Q
T
Q
F
L
K
E
L
V
E
P
V
S
R
-
F
F
E
EVN--
D
P
A
K
N
D
A
L
---------------
E
M
V
E
E
---
T
T
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
-
C
---
N
T
Q
Y
A
R
L
V
E
I
V
G
M
H
D
L
G
V
-
G
-
I
--
T
L
G
A
H
Q
S
----------------------
I
-------
G
-
F
K
G
I
L
L
F
G
T
--
K
A
Q
---
K
E
K
Y
L
P
K
L
A
S
G
E
T
-
V
A
A
F
-
C
L
T
E
P
S
S
-
G
S
D
-----
A
A
-
S
I
R
T
S
A
V
P
S
P
--
C
-
G
K
Y
--
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
--
F
T
V
F
A
K
T
---
P
---
V
T
D
PATG
A
V
K
-------
E
K
---
I
---
T
A
-----
F
---
V
----
V
E
R
G
F
---
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
--
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
-
E
-
N
V
L
G
-
E
V
-
G
S
G
-
F
-
K
V
-------
A
--
M
H
I
L
N
N
G
R
-------
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
--
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
V
M
L
----
Q
Y
V
T
E
S
M
A
Y
M
V
S
---------
A
N
M
D
Q
-------
G
A
T
D
F
Q
I
E
A
A
I
-
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
S
G
L
GS
A
L
K
N
PFGSGLSLSGLVHPEL
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
V
V
E
A
K
L
I
K
HKKGIVNE
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
E
GHPT
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
SDPW
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
GGVVTSNPLGF
7
PsiBlast_PDB
70.84
27%
-84
- C1 -
4N5F
9
?
A:
[36-365]
-----------------------------------------------------
A
A
Q
W
D
H
D
---------------
A
H
L
P
D
---
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
-
D
---
Y
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
-
A
-
T
--
M
M
S
V
H
N
S
----------------------
V
G
C
G
P
I
L
G
F
-
G
T
P
A
Q
K
D
R
W
--
L
A
D
---
M
A
A
--------
G
R
-
V
I
G
A
F
C
L
T
E
P
H
A
-
G
S
E
-----
A
N
-
N
L
R
--
T
R
A
E
L
--
R
-
D
G
Q
--
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
--
A
I
V
F
A
M
T
---
D
PEA
G
--------
K
-------
R
G
---
I
---
S
A
-----
F
---
L
----
V
P
T
D
T
---
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
--
S
D
T
C
P
I
T
F
E
N
C
A
I
-
P
-
E
-
D
N
L
L
------
G
-
N
-
R
G
E
G
L
K
I
A
L
S
--
N
L
--
E
G
G
R
-------
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
--
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
----
I
N
A
A
R
L
L
V
H
H
A
A
---------
K
L
R
T
A
-----
G
L
--
P
C
L
-
S
E
A
S
Q
-
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
69.64
18%
-98
- C1 -
4HR3
1
?
A:
[7-410]
---------
F
A
--------------
P
S
A
R
A
A
E
L
I
A
A
V
R
E
F
I
D
A
E
V
M
P
-----
V
E
R
A
V
L
A
H
H
D
E
L
L
G
A
RAGT
T
A
E
L
W
H
V
P
P
E
L
D
S
L
K
A
K
A
R
A
A
G
L
W
N
L
F
L
P
D
P
E
L
G
G
G
L
-
S
---
N
S
E
Y
A
P
L
A
E
Q
M
G
R
S
L
F
A
P
-
T
-
V
F
N
C
N
A
P
D
S
G
----------------------
N
-------
M
-
E
--
V
L
H
R
Y
G
--
S
Q
E
---
Q
K
E
V
W
L
E
P
L
L
E
G
D
I
R
S
A
F
-
C
M
T
E
P
D
V
A
S
S
D
-----
A
T
-
N
--
M
A
A
T
A
V
V
--
E
-
G
D
E
--
V
V
I
N
G
R
K
W
W
S
T
G
V
G
H
P
D
C
KV
I
I
F
M
G
L
T
---
D
---
P
--------
N
AHRY---
A
R
---
H
---
S
M
-----
V
---
L
----
V
P
M
D
T
---
P
G
I
T
V
E
R
M
L
P
T
M
G
F
Y
D
EP
G
G
H
G
V
V
S
F
D
N
V
R
L
-
P
-
A
-
D
A
F
I
-
A
G
-
P
G
K
-
G
F
E
I
A
Q
-----
G
--
R
L
--
G
P
G
R
-------
V
H
H
A
M
R
L
I
G
L
A
E
V
A
L
E
H
A
C
R
R
G
L
D
R
T
A
--
F
G
K
P
L
V
N
L
G
G
N
R
E
R
I
A
D
A
R
I
A
----
I
N
Q
T
R
L
L
V
L
H
A
A
---------
W
L
L
D
T
-----
V
G
I
-
M
G
A
L
S
A
V
S
E
-
I
K
V
A
A
P
N
M
A
Q
Q
V
I
D
M
A
I
Q
I
H
G
G
G
G
L
S
N
D
F
P
L
A
A
A
W
V
N
A
R
A
L
R
L
A
D
G
P
D
E
V
H
R
G
V
V
A
R
I
E
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.75
24%
-72
- C1 -
4L1F
7
?
A:
[1-357]
------
M
D
F
N
L
--------------
T
E
D
Q
Q
M
-----
I
K
D
M
A
A
E
-
F
A
E
K
FLAP
T
V
E
E
R
D
K
A
---------------
H
I
W
D
R
---
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
-
D
---
V
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
-
G
-
I
--
T
L
S
A
N
V
S
----------------------
L
-------
C
-
A
T
P
I
Y
M
F
G
T
--
E
E
Q
---
K
Q
K
Y
L
A
P
I
A
E
G
T
H
-
V
G
A
F
-
G
L
T
E
P
S
A
-
G
T
D
-----
A
S
-
A
Q
Q
--
T
T
A
V
L
--
K
-
G
D
K
--
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
--
Y
V
V
F
A
M
T
---
D
---
K
--------
S
-------
Q
G
---
V
HG
I
S
A
-----
F
---
I
----
L
E
K
G
M
---
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
--
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
-
E
-
N
L
L
G
-
K
E
-
G
E
G
-
F
-
K
I
-------
A
--
M
E
T
L
D
G
G
R
-------
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
--
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
----
I
E
A
A
R
Y
L
V
Y
H
A
A
---------
M
L
K
N
E
-----
G
--
K
P
Y
--
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
68.66
20%
-74
- C1 -
4IV6
2
?
A:
[7-383]
-------------------------
L
T
A
E
E
E
T
I
V
K
T
V
H
D
F
V
E
K
Q
V
K
P
-----
V
V
R
E
L
E
H
A
---------------
N
T
Y
P
E
---
E
L
I
E
T
M
K
E
I
G
I
F
G
L
A
I
P
E
P
Y
G
F
G
A
V
-
S
---
M
P
C
Y
V
Q
V
A
E
E
L
A
R
G
W
M
S
L
-
A
-
G
--
A
M
G
G
H
T
V
----------------------
V
-------
S
-
K
L
--
L
L
L
F
G
--
T
E
E
---
Q
K
Q
K
Y
L
P
R
M
A
T
G
E
L
R
A
T
M
-
A
L
T
E
P
G
G
-
G
S
D
-----
L
Q
-
A
--
M
R
T
V
A
R
R
--
D
-
G
D
D
--
Y
V
I
N
G
S
K
T
W
I
S
N
A
R
R
S
D
L
--
V
A
L
M
C
K
T
---
D
---
P
DAQPA---
H
-------
K
G
---
V
---
S
I
-----
L
---
L
----
V
E
K
-
V
---
P
G
F
D
V
S
R
D
L
P
K
L
G
Y
K
G
--
V
E
S
C
E
L
N
F
T
D
A
R
V
-
P
-
V
-
S
S
L
L
-
G
D
D
E
G
R
-
G
F
A
Q
M
M
-----
K
--
G
L
--
E
V
G
R
-------
L
Q
V
A
A
R
A
T
G
V
A
R
A
A
F
E
D
A
L
R
Y
S
Q
E
R
E
S
--
F
G
K
P
I
W
Q
H
Q
S
V
G
N
M
L
A
D
M
G
T
K
----
L
Y
A
A
R
S
L
L
L
S
A
A
---------
E
K
F
D
A
-----
G
Q
---
R
C
D
M
E
A
G
M
-
A
K
L
F
A
S
E
T
A
M
Q
I
A
L
D
A
V
R
V
H
G
G
Y
G
Y
S
T
E
Y
D
V
E
R
Y
F
R
D
A
P
L
M
I
V
G
E
G
T
N
E
I
Q
R
N
V
I
A
K
Q
L
V
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
68.35
18%
-81
- C1 -
1SIQ
1
GCDH_HUMAN
A:
[10-384]
-------
L
E
E
Q
--------------
L
T
T
D
E
I
L
I
R
D
T
F
R
T
Y
C
Q
E
R
L
M
P
-----
R
I
L
L
A
N
R
N
---------------
E
V
F
H
R
---
E
I
I
S
E
M
G
E
L
G
V
L
G
P
T
I
K
-
G
Y
G
C
A
G
V
-
S
---
S
V
A
Y
G
L
L
A
R
E
L
E
R
V
D
S
G
Y
-
R
-
S
--
A
M
S
V
Q
S
S
----------------------
L
-------
V
-
M
H
-
P
I
Y
A
Y
G
--
S
E
E
---
Q
R
Q
K
Y
L
P
Q
L
A
K
G
E
L
L
G
C
F
-
G
L
T
E
P
N
S
-
G
S
D
-----
P
S
-
S
--
M
E
T
R
A
H
Y
NS
S
-
N
K
S
--
Y
T
L
N
G
T
K
T
W
I
T
N
S
P
M
A
D
L
--
F
V
V
W
A
R
C
---
E
---
D
----------------
G
C
---
I
---
R
G
-----
F
---
L
----
L
E
K
G
M
---
R
G
L
S
A
P
R
I
Q
G
K
F
S
L
R
A
--
S
A
T
G
M
I
I
M
D
G
V
E
V
-
P
-
E
-
E
N
V
L
-
P
G
-
A
S
S
-
L
-
G
G
P
F
-----
G
--
C
L
--
N
N
A
R
-------
Y
G
I
A
W
G
V
L
G
A
S
E
F
C
L
H
T
A
R
Q
Y
A
L
D
R
M
Q
--
F
G
V
P
L
A
R
N
Q
L
I
Q
K
K
L
A
D
M
L
T
E
----
I
T
L
G
L
H
A
C
L
Q
L
G
---------
R
L
K
D
Q
-----
D
K
---
A
A
P
E
M
V
S
L
-
L
K
R
N
N
C
G
K
A
L
D
I
A
R
Q
A
R
D
M
L
G
G
N
G
I
S
D
E
Y
H
V
I
R
H
A
M
N
L
E
A
V
N
T
Y
E
G
T
H
D
I
H
A
L
I
L
G
R
A
I
T
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
67.59
25%
-90
- C1 -
4KCF
2
?
A:
[40-398]
------------------------------
R
V
L
L
D
R
L
A
A
H
L
P
R
-
I
R
S
-----
T
A
A
E
H
D
R
D
---------------
G
T
F
P
T
---
D
T
F
D
A
L
R
K
D
G
L
M
G
A
T
V
P
A
E
L
G
G
L
G
V
-
D
R--
L
Y
D
V
A
V
A
L
L
A
V
A
R
A
D
A
S
T
-
A
-
L
--
A
L
--
H
M
Q
----------------------
L
-------
S
-
R
G
L
T
L
G
Y
E
W
R
H
G
D
E
---
R
A
R
T
L
A
E
R
I
L
R
G
M
-
V
-----
A
G
D
A
V
V
-
C
S
G
-----
I
K
-
D
H
H
T
A
V
T
T
L
R
--
P
-
D
G
A
G
G
W
L
L
S
G
R
K
T
L
V
S
M
A
P
V
G
T
H
--
F
V
I
N
A
R
T
---
D
---
G
--------
T
-------
D
G
---
P
---
P
R
-----
L
A
S
P
V
----
V
T
R
D
T
---
P
G
F
T
V
L
D
N
W
D
G
L
G
M
R
A
--
S
G
T
V
D
I
V
F
D
D
C
P
I
-
P
-
A
-
D
H
V
---
L
-
M
R
D
-
P
-
V
G
-------
A
--
R
N
--
D
A
V
L
A
G
Q
T
V
S
S
V
S
V
L
G
V
Y
V
G
V
A
Q
A
A
Y
D
T
A
V
A
A
L
E
R
R
P
E
P
P
Q
A
A
A
L
T
L
V
A
E
I
D
S
R
L
Y
A
L
R
A
T
A
G
S
A
L
T
A
A
D
A
L
S
A
D
L
S
---------
G
D
M
D
E
-------
R
G
R
Q
M
M
R
H
F
Q
C
-
A
K
L
A
V
N
R
L
A
P
E
I
V
S
D
C
L
S
L
V
G
G
A
S
Y
T
A
G
H
P
L
A
R
L
L
R
D
V
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
67.35
17%
-79
- C1 -
1RX0
8
ACAD8_HUMAN
A:
[15-393]
-------
P
S
M
G
--------------
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
-----
N
M
A
E
W
D
Q
K
---------------
E
L
F
P
V
---
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
-
S
---
R
L
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
T
-
T
-
A
--
Y
I
S
I
H
N
M
----------------------
C
-------
A
-
W
M
--
I
D
S
F
G
--
N
E
E
---
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
-
C
L
T
E
P
G
S
-
G
S
D
-----
A
A
-
S
--
L
L
T
S
A
K
K
--
Q
-
G
D
H
--
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
--
Y
V
V
M
C
R
T
---
G
---
G
PG------
P
-------
K
G
---
I
---
S
C
-----
I
---
V
----
V
E
K
G
T
---
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
--
Q
P
T
R
A
V
I
F
E
D
C
A
V
-
P
-
V
-
A
N
R
I
-
G
S
-
E
G
Q
-
G
F
L
I
A
V
-----
R
--
G
L
--
N
G
G
R
-------
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
--
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
----
L
V
A
A
R
L
M
V
R
N
A
A
---------
V
A
L
Q
E
-----
E
R
--
K
D
A
V
A
L
C
S
M
-
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
67.07
20%
-66
- C1 -
4P13
3
ACADM_HUMAN
A:
[2-383]
------
G
F
S
F
E
--------------
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
-----
V
A
A
E
Y
D
K
T
---------------
G
E
Y
P
V
---
P
L
I
R
R
A
W
E
L
G
L
M
N
T
H
I
P
E
N
C
G
G
L
G
L
-
G
---
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
T
G
V
-
Q
-
T
--
A
I
E
G
N
S
L
----------------------
G
-------
Q
-
M
P
--
I
I
I
A
G
--
N
D
Q
---
Q
K
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
-
C
V
T
E
P
G
A
-
G
S
D
-----
V
A
-
G
--
I
K
T
K
A
E
K
--
K
-
G
D
E
--
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
--
Y
F
L
L
A
R
S
---
D
---
P
--------
D
PKAPAN-
K
A
---
F
---
T
G
-----
F
---
I
----
V
E
A
D
T
---
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
--
S
D
T
R
G
I
V
F
E
D
V
K
V
-
P
-
K
-
E
N
V
L
-
I
G
-
D
G
A
-
G
F
K
V
A
M
-----
G
--
A
F
--
D
K
T
R
-------
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
--
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
M
A
M
E
----
V
E
L
A
R
M
S
Y
Q
R
A
A
---------
W
E
V
D
S
-----
G
R
---
R
N
T
Y
Y
A
S
I
-
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.68
24%
-89
- C1 -
2JIF
9
ACDSB_HUMAN
A:
[56-382]
---------------------------------------------------------
D
E
N
---------------
S
K
M
E
K
---
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
-
S
---
F
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
-
A
-
V
--
F
C
E
I
Q
N
T
----------------------
L
-------
I
-
N
T
L
I
R
K
H
G
T
--
E
E
Q
---
K
A
T
Y
L
P
-
Q
L
T
T
E
K
-
V
G
S
F
-
C
L
S
E
A
G
A
-
G
S
D
-----
S
F
-
A
L
K
--
T
R
A
D
K
--
E
-
G
D
Y
--
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
--
F
L
V
M
A
N
V
---
D
---
P
-----------------
T
---
I
---
G
Y
KG
I
T
S
F
---
L
----
V
D
R
D
T
---
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
--
S
S
T
C
P
L
T
F
E
N
V
K
V
-
P
-
E
A
N
I
L
G
-
Q
I
-
G
H
G
-
Y
-
K
Y
-------
A
I
G
S
L
--
N
E
G
R
-------
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
--
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
----
L
E
A
A
R
L
L
T
Y
N
A
A
---------
R
L
L
E
-------
A
G
K
P
F
I
-
K
E
A
S
M
-
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
66.41
22%
-71
- C1 -
4IRN
3
?
A:
[39-415]
----------
A
--------------
W
N
S
Q
Q
I
Q
F
R
K
K
V
I
Q
F
A
Q
Q
S
L
I
S
-----
D
L
I
K
N
D
K
E
---------------
E
I
F
N
R
---
D
A
W
Q
K
C
S
E
F
G
V
H
G
W
P
I
P
A
R
Y
G
G
Q
E
L
-
D
---
I
L
T
T
A
Y
A
L
Q
G
L
G
Y
G
C
K
D
N
-
G
-
L
--
I
F
A
M
N
A
H
----------------------
I
-------
W
A
C
E
M
P
L
L
T
F
G
--
T
E
E
---
Q
K
E
K
Y
L
P
L
L
C
R
G
G
W
I
A
S
H
-
A
A
T
E
P
Q
A
-
G
S
D
-----
I
Y
-
S
--
L
K
T
T
A
Q
K
--
D
-
G
D
K
--
Y
I
L
N
G
Y
K
H
Y
V
T
N
G
T
I
A
D
L
--
F
I
I
F
A
T
I
---
D
---
P
SLG-----
K
-------
E
G
---
L
---
T
T
-----
F
---
M
----
I
E
K
D
T
---
P
G
L
I
L
S
K
P
I
S
K
M
G
M
R
T
--
A
E
V
P
E
L
R
L
E
N
C
E
V
-
S
-
A
-
A
N
R
L
-
G
E
-
E
G
T
-
G
L
A
I
F
N
-----
H
--
S
M
--
E
W
E
R
-------
G
F
I
L
A
A
A
V
G
T
M
E
R
L
L
E
Q
S
I
R
Y
A
R
S
H
K
Q
--
F
G
Q
A
I
G
K
F
Q
L
V
A
N
K
L
V
E
M
K
L
R
----
L
E
N
A
K
A
Y
L
Y
K
V
A
---------
W
M
K
E
N
-----
K
Q
---
M
A
L
L
E
A
S
M
-
A
N
L
Y
I
S
E
A
W
V
Q
S
C
L
E
A
I
E
I
H
G
A
Y
G
Y
L
T
N
T
E
L
E
R
E
L
R
D
A
I
A
S
K
F
Y
S
G
T
S
E
I
Q
R
V
V
I
A
K
F
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.35
24%
-83
- C1 -
5AF7
3
?
A:
[23-360]
--------------------------------------------
F
A
S
-----
T
A
V
Q
T
D
L
T
---------------
E
Q
Y
P
W
---
D
N
V
A
Q
L
R
D
A
G
F
M
G
M
M
L
P
T
S
V
G
G
R
G
L
-
S
---
T
L
D
T
V
I
V
I
E
E
M
A
K
A
C
A
T
M
-
G
R
I
--
T
V
D
S
N
L
G
----------------------
A
-------
I
-
G
A
I
T
K
Y
G
S
----
E
E
---
Q
I
K
L
A
A
D
L
V
L
A
G
D
-
K
P
A
I
-
C
I
S
E
P
N
A
-
G
S
A
ASEMT
T
R
-
A
D
K
N
G
D
H
------------
Y
I
L
N
G
E
K
Y
W
I
T
G
G
G
V
S
K
L
--
H
L
I
F
A
R
V
---
F
---
D
DGV-----
E
-------
Q
G
---
I
---
G
A
-----
F
---
I
----
T
V
L
D
D
HGP
E
G
L
K
V
G
R
R
L
Y
A
M
G
V
R
G
--
I
P
E
T
H
L
E
F
H
D
L
K
I
-
H
-
K
-
S
M
M
I
-
T
F
-
P
D
G
L
K
-
R
G
F
A
A
L
M
--
S
--
A
Y
--
N
A
Q
R
-------
V
G
A
G
A
V
A
L
G
I
A
Q
C
A
F
E
E
G
V
A
Y
L
K
R
R
--
E
Q
F
G
R
P
L
A
E
F
Q
G
L
Q
W
M
V
A
D
M
S
V
Q
----
L
E
A
A
R
L
M
L
R
S
A
A
V
SG------
E
T
F
P
D
------------
I
N
K
A
A
Q
-
A
K
I
F
A
A
E
T
A
N
K
V
T
N
D
A
L
Q
F
F
G
S
S
G
Y
G
R
H
N
P
M
E
R
H
V
R
D
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------