@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04580: (2016-06-07 )
MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVIGQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKVLPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNMGFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQFYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLTQAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGRAGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTISENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRSSKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY
Atome Classification :
(72 SA)
.......-..10.......-.20........30........--40-.-.--.......50........60...-..----..------------------.---------70--.---.---------.------------------......80........90.....-.----.----.-100-......-...110......-.-120-........130-----....-..-.---140...-....150......-.160-........170.--..----.-------..--.--------..180.......190.......-------------200.......----210---....--....220..-.-.-.-.----.----230.....-.----------.240-.-......250.......260---..---.....270.......280.......290.......300.......310.......320----..------.......330.......340.......-350........360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
T
F
QD-FNL
S
S
D
L
M
K
A
I
-
N
RMGFEEATPIQ
A
Q
T
I
PLGLS--N--K-D--VIGQAQTGTGKTAAFGI
P
L
V
E
K-IN----PE------------------S---------P---
N
---
I
---------
Q
------------------
A
I
V
IAPT
R
E
L
A
I
Q
V
S
E
E
L
Y
K
IGQ-D----K----R-
A
---
K
V
L
P
IY-G
G
Q
D
I
G
R
Q
I
R
A
L-K-K-N-P
N
I
I
VGT
P
G
R
L
-----
L
D
H
I-NR-
R
---
T
I
R
LNN-
V
N
T
V
V
MD
E
A
D
E
M
L
-NM-G-
F
I
D
D
I
E
S
I
L
--
S
--NV----P-------SE--H--------
Q
T
L
L
F
SATM
P
A
P
I
K
R
I
A
E
R
FMT-------------EPE
H
V
K
V
K
A
K
----EM----
T
V
S
N
--
I
Q
Q
F
Y
L
E
V
Q
-
E
-
R
-
K
-
K
----
F
----
D
T
L
T
R
L
L
D-I----------QSP
E
-
L
-
A
I
V
FG
R
T
K
R
R
V
D
E
L
A
E
A
LN---LR---GYAAEGIH
G
D
L
T
Q
A
K
R
M
V
A
L
R
K
FKEG
A
I
E
V
L
V
ATDVAARGLDISG
V
T
H
V
Y
NFDVPQ------D
P
------
E
S
Y
V
H
R
IGRTGRAGKT
G
M
A
M
T
F
ITP
R
E
-
K
-
S
M
L
R
A
I
E
Q
T
T
K
R
K
M
D
RMKEP
T
L
D
E
A
LEG
Q
Q
Q
V
T
V
E
R
L
R
T
T
ISENN
L
N
F
Y
M
T
A
A
A
E
L
L
EDH
D
A
V
T
V
V
A
A
A
I
K
MATKEPDDT
P
V
R
LTDEAP
M
V
S
K
R
Y
K
N
QRSSKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY
1
PsiBlast_PDB
81.22
47%
-124
- C2 -
1HV8
5
H669_METJA
A:
[7-356]
---
N
F
N
E
-
L
N
L
S
D
N
I
L
N
A
I
-
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
--
D
--
E
Y
N
--
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
-
V
N
-----
E
------------------
N
---------
N
---
G
---
I
---------
E
------------------
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
-
N
----
K
----
N
-
L
---
K
I
A
K
I
Y
-
G
G
K
A
I
Y
P
Q
I
K
A
L
-
K
---
N
-
A
N
I
V
V
G
T
P
G
R
I
-----
L
D
H
I
-
N
R
-
G
---
T
L
N
L
K
N
-
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
M
-
G
-
F
I
K
D
V
E
K
I
L
--
N
--
A
C
----
N
-------
K
D
--
K
--------
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
-------------
D
Y
S
F
I
K
A
K
I
N
------------
A
N
--
I
E
Q
S
Y
V
E
V
N
-
E
-
N
-
E
-
R
----
F
----
E
A
L
C
R
L
L
-------------
K
N
K
E
-
F
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
---
D
I
---
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
-
Y
-
K
K
L
R
Y
I
E
R
A
---------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
80.48
41%
-119
- C2 -
4PXA
5
DDX3X_HUMAN
A:
[65-444]
--
E
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
---
Y
---
P
---------
I
------------------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
--
Q
D
----
T
MPPK---
G
V
--
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
R
V
----
G
S
----
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
T---------
G
K
D
S
-
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
K
D
L
L
D
L
---------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
80.42
41%
-132
- C2 -
2I4I
1
DDX3X_HUMAN
A:
[15-391]
--
E
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
---------
Q
---
Y
---
P
---------
I
------------------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
--
Q
D
TMPP
K
-------
G
V
--
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
------------
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
A
T
----------
G
K
D
S
-
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
K
D
L
------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.76
40%
-134
- C2 -
2I4I
1
DDX3X_HUMAN
A:
[16-383]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
QD
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
------------
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
79.29
48%
-118
- C2 -
1HV8
5
H669_METJA
A:
[6-364]
--
M
N
F
N
E
-
L
N
L
S
D
N
I
L
N
A
I
-
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
--
D
E-
Y
-
N
--
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
-
V
N
----
E
-------------------
N
---------
N
---
G
---
I
---------
E
------------------
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
-
N
----
K
----
N
-
L
---
K
I
A
K
I
Y
-
G
G
K
A
I
Y
P
Q
I
K
-
A
-
L
-
K
-
N
-
A
N
I
V
V
G
T
P
G
R
I
-----
L
D
H
I
-
N
R
-
G
---
T
L
N
L
K
N
-
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
M
-
G
-
F
I
K
D
V
E
K
I
L
--
N
--
A
C
----
N
-------
K
D
--
K
--------
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
-------------
D
Y
S
F
I
K
A
K
------------
I
N
A
N
--
I
E
Q
S
Y
V
E
V
N
-
E
-
N
-
E
-
R
----
F
----
E
A
L
C
R
L
L
K
-
N
-----------
K
E
F
-
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
---
D
I
---
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
-
Y
-
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
L
-------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.67
40%
-121
- C2 -
4PXA
5
DDX3X_HUMAN
A:
[66-433]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
QD
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
R
V
----
G
S
----
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
76.38
36%
-144
- C2 -
2VSO
1
IF4A_YEAST
B:
[24-386]
----
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
-
D
--
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
D
----
T
S
------------------
V
---------
K
---
A
---
P
---------
Q
------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
----
M
----
D
-
I
---
K
V
H
A
C
I
-
G
----------
L
-
R
---
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
---
R
F
R
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
--
L
L
----
P
-------
P
T
--
T
--------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
-------------
N
P
V
R
I
L
V
K
K
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
S
V
T
-
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
76.12
36%
-144
- C2 -
2VSO
1
IF4A_YEAST
A:
[24-386]
----
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
-
D
--
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
D
----
T
S
------------------
V
---------
K
---
A
---
P
---------
Q
------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
----
M
----
D
-
I
---
K
V
H
A
C
I
-
G
----------
L
-
R
---
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
---
R
F
R
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
--
L
L
----
P
-------
P
T
--
T
--------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
-------------
N
P
V
R
I
L
V
K
K
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
S
V
T
-
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
75.89
35%
-140
- C2 -
5ANR
-
DDX6_HUMAN
B:
[95-458]
-
G
N
E
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
-
L
D
----
L
K
------------------
K
---------
D
---
N
---
I
---------
Q
------------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
-
H
----
M
G---
G
-
A
---
K
V
M
A
T
T
-
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
-----
L
D
L
I
-
K
K
-
G
---
V
A
K
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
--
L
--
T
L
----
P
-------
K
N
--
R
--------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
-------------
K
P
Y
E
I
N
L
M
E
E
-----
L
----
T
L
K
G
--
V
T
Q
Y
Y
A
Y
V
T
-
E
-
R
-
Q
-
K
----
V
----
H
C
L
N
T
L
F
S
-
R
----------
L
Q
I
N
-
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.73
40%
-124
- C2 -
5E7I
-
DDX3X_HUMAN
B:
[181-548]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
L
R
A
MKERK
Q
Y
P
I
------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
E
Q
D
--
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
R
V
----
G
S
----
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
--------
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
75.59
40%
-119
- C2 -
5E7M
1
DDX3X_HUMAN
A:
[49-416]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
L
R
A
M
KR
R
K
Q
Y
P
I------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
EQ
D
--
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
R
V
----
G
S
----
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.42
40%
-117
- C2 -
5E7J
1
DDX3X_HUMAN
A:
[49-416]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
L
R
A
M
KKQYPI--------
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
EQ
D
--
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
Y
I
F
L
A
V
G
R
V
----
G
S
----
T
S
E
N
--
I
T
Q
K
V
V
W
V
E
-
E
-
S
-
D
-
K
----
R
----
S
F
L
L
D
L
L
N
-
A
----------
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
---
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.11
36%
-142
- C2 -
5ANR
-
DDX6_HUMAN
B:
[98-451]
----
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
-
L
D
----
L
K
------------------
K
---------
D
---
N
---
I
---------
Q
------------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
-
H
----
M
----
G
G
A
---
K
V
M
A
T
T
-
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
-----
L
D
L
I
-
K
K
-
G
---
V
A
K
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
--
L
--
T
L
----
P
-------
K
N
--
R
--------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
-------------
K
P
Y
E
I
N
L
-
M
E
----
E
L
----
T
L
K
G
--
V
T
Q
Y
Y
A
Y
V
T
-
E
-
R
-
Q
-
K
----
V
----
H
C
L
N
T
L
F
S
-
R
----------
L
Q
I
N
-
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.11
39%
-114
- C2 -
2HYI
3
IF4A3_HUMAN
C:
[36-413]
V
T
P
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
-
L
D
----
I
Q
------------------
V
---------
R
---
E
---
T
---------
Q
------------------
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
----
M
----
N
-
V
---
Q
C
H
A
C
I
-
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
---
S
L
R
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
--
R
--
Y
L
----
P
-------
P
A
--
T
--------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
-------------
D
P
I
R
I
L
V
K
R
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
F
V
A
V
E
R
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
T
I
T
-
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
---------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
75.09
36%
-133
- C2 -
4CT4
2
DDX6_HUMAN
D:
[7-360]
----
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
-
L
D
----
L
K
------------------
K
---------
D
---
N
---
I
---------
Q
------------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
-
H
----
M
----
G
G
A
---
K
V
M
A
T
T
-
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
-----
L
D
L
I
-
K
K
-
G
---
V
A
K
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
--
L
--
T
L
----
P
-------
K
N
--
R
--------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
-------------
K
P
Y
E
I
N
L
-
M
E
----
E
L
----
T
L
K
G
--
V
T
Q
Y
Y
A
Y
V
T
-
E
-
R
-
Q
-
K
----
V
----
H
C
L
N
T
L
F
S
-
R
----------
L
Q
I
N
-
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
75.00
32%
-131
- C2 -
3EWS
1
DD19B_HUMAN
A:
[63-442]
---
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
E
----
P
A
------------------
N
---------
K
---
Y
---
P
---------
Q
------------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-------
K
----
F
-
Y
---
P
E
L
K
L
A
-
Y
A
V
R
G
N
K
L
E
R
G
Q
-
K
-
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
---
F
I
D
P
K
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
--
M
L
----
P
-------
R
N
--
C
--------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
-------------
D
P
N
V
I
K
L
K
R
E
----
E
E
----
T
L
D
T
--
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
T
I
A
-
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
T
D
D
L
D
-------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.76
36%
-139
- C2 -
4CT4
3
DDX6_HUMAN
B:
[7-360]
----
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
-
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
-
L
D
----
L
K
------------------
K
---------
D
---
N
---
I
---------
Q
------------------
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
-
H
----
M
----
G
G
A
---
K
V
M
A
T
T
-
G
G
T
N
L
R
D
D
I
M
R
L
-
D
-
D
-
T
-
V
H
V
V
I
A
T
P
G
R
I
-----
L
D
L
I
-
K
K
-
G
---
V
A
K
V
D
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
Q
-
D
-
F
V
Q
I
M
E
D
I
I
--
L
--
T
L
----
P
-------
K
N
--
R
--------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
-------------
K
P
Y
E
I
N
L
-
M
E
----
E
L
----
T
L
K
G
--
V
T
Q
Y
Y
A
Y
V
T
-
E
-
R
-
Q
-
K
----
V
----
H
C
L
N
T
L
F
S
-
R
----------
L
Q
I
N
-
Q
-
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
---
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.67
39%
-114
- C2 -
3EX7
4
IF4A3_HUMAN
C:
[36-413]
V
T
P
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
-
L
D
----
I
Q
------------------
V
---------
R
---
E
---
T
---------
Q
------------------
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
----
M
----
N
-
V
---
Q
C
H
A
C
I
-
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
---
S
L
R
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
--
R
--
Y
L
----
P
-------
P
A
--
T
--------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
-------------
D
P
I
R
I
L
V
K
R
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
F
V
A
V
E
R
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
T
I
T
-
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
P
M
N
V
A
D
L
I
L
E
---------------------------------------------------------------------------------------------------------------------
116
HHSearch
74.41
40%
-136
- C2 -
3EIQ
-
IF4A1_HUMAN
A:
[32-399]
--
D
S
F
D
D
-
M
N
L
S
E
S
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
--
G
--
Y
-
D
--
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
Q
-
I
E
----
L
D
------------------
L
---------
K
---
A
---
T
---------
Q
------------------
A
L
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
-
Y
----
M
----
G
-
A
---
S
C
H
A
C
I
-
G
G
T
N
V
R
A
E
V
Q
K
L
-
Q
M
E
-
A
-
P
H
I
I
V
G
T
P
G
R
V
-----
F
D
M
L
-
N
R
-
R
---
Y
L
S
P
K
Y
-
I
K
M
F
V
L
D
E
A
D
E
M
L
-
S
R
-
G
-
F
K
D
Q
I
Y
D
I
F
--
Q
--
K
L
----
N
-------
S
N
--
T
--------
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
M
R
-------------
D
P
I
R
I
L
V
K
K
E
----
E
L
----
T
L
E
G
--
I
R
Q
F
Y
I
N
V
E
-
R
E
E
-
W
-
K
----
L
----
D
T
L
C
D
L
Y
E
-
T
----------
L
T
I
T
-
Q
-
A
V
I
F
I
N
T
R
R
K
V
D
W
L
T
E
K
M
H
---
A
R
---
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
T
------
N
R
------
E
N
Y
I
H
R
I
G
R
G
-------
V
A
I
N
M
V
T
E
E
D
-
K
-
R
T
L
R
D
I
E
T
F
Y
N
T
S
I
E
E
M
P
------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.34
42%
-126
- C2 -
4KBF
1
?
B:
[1-364]
--
M
E
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
I
K
D
----
E
P
----
V
T
Y
E
--
E
E
A
V
P
A
P
V
----
R
-
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
S
P
D
-
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
-
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
-------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
74.07
43%
-106
- C2 -
4KBF
3
?
A:
[1-362]
--
M
E
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
QER---------------
G
---------
R
---
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
-----------
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
I
K
D
----
E
P
----
V
T
Y
E
----
E
E
A
V
P
A
P
-
V
-
R
-
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
S
P
D
-
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
-
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
---------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
74.03
36%
-140
- C2 -
2VSX
1
IF4A_YEAST
B:
[24-386]
----
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
-
D
--
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
D
----
T
S
------------------
V
---------
K
---
A
---
P
---------
Q
------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
----
M
----
D
-
I
---
K
V
H
A
C
I
-
G
----------
L
-
R
---
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
---
R
F
R
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
--
L
L
----
P
-------
P
T
--
T
--------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
-------------
N
P
V
R
I
L
V
K
K
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
S
V
T
-
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
73.80
36%
-140
- C2 -
2VSX
1
IF4A_YEAST
A:
[24-386]
----
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
-
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
-
D
--
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
D
----
T
S
------------------
V
---------
K
---
A
---
P
---------
Q
------------------
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
----
M
----
D
-
I
---
K
V
H
A
C
I
-
G
----------
L
-
R
---
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
-
R
---
R
F
R
T
D
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
--
L
L
----
P
-------
P
T
--
T
--------
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
-------------
N
P
V
R
I
L
V
K
K
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
Y
V
N
V
E
-
E
-
E
-
E
Y
K
----
Y
----
E
C
L
T
D
L
Y
D
-
S
----------
I
S
V
T
-
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
---
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
L
-------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.66
39%
-115
- C2 -
2J0S
3
IF4A3_HUMAN
A:
[35-402]
V
T
P
T
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
-
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
-
L
D
----
I
Q
------------------
V
---------
R
---
E
---
T
---------
Q
------------------
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
----
M
----
N
-
V
---
Q
C
H
A
C
I
-
G
G
T
N
V
G
E
D
I
R
K
L
-
D
-
Y
-
G
-
Q
H
V
V
A
G
T
P
G
R
V
-----
F
D
M
I
-
R
R
-
R
---
S
L
R
T
R
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
K
-
G
-
F
K
E
Q
I
Y
D
V
Y
--
R
--
Y
L
----
P
-------
P
A
--
T
--------
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
-------------
D
P
I
R
I
L
V
K
R
D
----
E
L
----
T
L
E
G
--
I
K
Q
F
F
V
A
V
E
R
E
-
E
-
W
-
K
----
F
----
D
T
L
C
D
L
Y
D
-
T
----------
L
T
I
T
-
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
---
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
M
-------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.35
42%
-109
- C2 -
4KBF
3
?
A:
[1-364]
--
M
E
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
I
K
D
----
E
P
----
V
T
Y
E
--
E
E
A
V
P
A
P
V
----
R
-
G
-
R
----
L
----
E
V
L
S
D
L
L
Y
-
V
----------
A
S
P
D
-
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
---
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
-
R
D
V
E
A
L
E
R
A
V
G
R
R
F
K
R
V
-------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
72.79
32%
-142
- C2 -
4LJY
4
PRP5_YEAST
A:
[50-436]
--
T
K
W
S
Q
-
L
G
L
S
T
D
T
M
V
L
I
T
E
K
L
H
F
G
S
L
T
P
I
Q
S
Q
A
L
P
A
I
M
S
--
G
--
R
-
D
--
V
I
G
I
S
K
T
G
S
G
K
T
I
S
Y
L
L
P
L
L
R
Q
-
V
K
----
A
Q
------------------
R
PLSKHE---
T
---
G
---
P
---------
M
------------------
G
L
I
L
A
P
T
R
E
L
A
L
Q
I
H
E
E
V
T
K
F
T
E
-
A
D---
T
----
S
-
I
---
R
S
V
C
C
T
-
G
G
S
E
M
K
K
Q
I
T
D
L
-
K
-
R
-
G
-
T
E
I
V
V
A
T
P
G
R
F
-----
I
D
I
L
-
T
L
-
N
DGK
L
L
S
T
K
R
-
I
T
F
V
V
M
D
E
A
D
R
L
F
-
D
L
-
G
-
F
E
P
Q
I
T
Q
I
M
--
K
--
T
V
----
R
-------
P
D
--
K
--------
Q
C
V
L
F
S
A
T
F
P
N
K
L
R
S
F
A
V
R
V
L
H
-------------
S
P
I
S
I
T
I
N
S
K
----
G
M
----
V
N
E
N
--
V
K
Q
K
F
R
I
C
H
S
E
-
D
-
E
-
K
----
F
----
D
N
L
V
Q
L
I
H
-
E
R
S
E
F
F
D
E
V
Q
S--
D
A
-
K
-
A
I
I
F
V
S
S
Q
N
I
C
D
F
I
S
K
K
L
L
---
N
A
---
G
I
V
T
C
A
I
H
A
G
K
P
Y
Q
E
R
L
M
N
L
E
K
F
K
R
E
K
N
S
I
L
L
C
T
E
V
L
S
R
G
L
N
V
P
E
V
S
L
V
I
I
Y
N
A
V
K
------
T
F
------
A
Q
Y
V
H
T
T
G
R
T
A
R
G
S
R
S
G
T
A
I
T
L
L
L
H
D
E
-
L
-
S
G
A
Y
I
L
S
-----------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
72.44
40%
-107
- C2 -
2DB3
3
VASA1_DROME
A:
[56-408]
--
Q
H
F
T
S
-
A
D
L
R
D
I
I
I
D
N
V
-
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
-
L
L
----
E
D
------------------
P
H
E
L
E
L
----
G
---
R
---
P
---------
Q
------------------
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
----
S
----
Y
-
L
---
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
-
R
-
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
-
T
---
F
I
T
F
E
D
-
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
S
E
D
M
R
R
I
M
--
T
--
H
V
----
T
MR-----
P
E
--
H
--------
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
-------------
N
Y
V
F
V
A
I
G
I
V
----
G
G
----
A
C
S
D
--
V
K
Q
T
I
Y
E
V
N
-
K
-
Y
-
A
-
K
----
R
----
S
K
L
I
E
I
L
S
------------
E
Q
A
D
-
G
-
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
---
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
71.23
32%
-121
- C2 -
3FHT
6
DD19B_HUMAN
B:
[26-400]
---
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
E
----
P
A
------------------
N
---------
K
---
Y
---
P
---------
Q
------------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-------
K
----
F
-
Y
---
P
E
L
K
L
A
-
Y
A
V
R
G
N
-------
K
-
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
---
F
I
D
P
K
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
--
M
L
----
P
-------
R
N
--
C
--------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
-------------
D
P
N
V
I
K
L
K
R
E
----
E
E
----
T
L
D
T
--
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
T
I
A
-
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.98
38%
-136
- C2 -
4BRW
2
DHH1_YEAST
A:
[2-355]
---
T
F
E
D
-
F
Y
L
K
R
E
L
L
M
G
I
-
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
-
V
K
----
P
K
------------------
L
---------
N
---
K
---
I
---------
Q
------------------
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
-
H
----
C
----
G
-
I
---
S
C
M
V
T
T
-
G
G
T
N
L
R
D
D
I
L
R
L
-
N
-
E
-
T
-
V
H
I
L
V
G
T
P
G
R
V
-----
L
D
L
A
-
S
R
-
K
---
V
A
D
L
S
D
-
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
R
-
D
-
F
K
T
I
I
E
Q
I
L
--
S
--
F
L
----
P
-------
P
T
--
H
--------
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
-------------
K
P
Y
E
I
N
L
-
M
E
----
E
L
----
T
L
K
G
--
I
T
Q
Y
Y
A
F
V
E
-
E
-
R
-
Q
-
K
----
L
----
H
C
L
N
T
L
F
S
-
K
----------
L
Q
I
N
-
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
---
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
-
R
-
F
N
L
Y
K
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
70.87
37%
-109
- C2 -
4D25
4
?
A:
[50-421]
--
E
S
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
-
D
--
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
-
L
L
----
Q
D
------------------
P
KD
L
I
S
E
NG
C
A
---
Q
---
P
---------
Q
------------------
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
----
S
----
V
-
L
---
K
V
A
V
A
Y
-
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
-
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
-----
H
D
F
V
-
E
R
-
N
---
R
V
S
F
G
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
--
L
--
H
P
TMVE
T
-------
T
K
--
R
--------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
-------------
N
Y
L
F
V
A
V
G
I
V
----
G
G
----
A
S
T
D
--
V
E
Q
I
F
I
E
V
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
K
Q
L
I
E
-
E
----------
N
D
G
K
-
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
D
L
-
A
L
V
A
D
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.27
37%
-110
- C2 -
4D25
4
?
A:
[51-404]
---
S
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
-
D
--
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
-
L
L
----
Q
D
------------------
P
---------
K
---
D
---
L
I
S
E
NG
C
A
Q
P
Q
------------------
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
----
S
----
V
-
L
---
K
V
A
V
A
Y
-
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
-
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
-----
H
D
F
V
-
E
R
-
N
---
R
V
S
F
G
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
--
L
--
H
P
----
T
MVET---
T
K
--
R
--------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
-------------
N
Y
L
F
V
A
V
G
I
V
----
G
G
----
A
S
T
D
--
V
E
Q
I
F
I
E
V
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
K
Q
L
I
E
-
E
----------
N
D
G
K
-
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
70.18
32%
-118
- C2 -
3G0H
4
DD19B_HUMAN
A:
[42-416]
---
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
E
----
P
A
------------------
N
---------
K
---
Y
---
P
---------
Q
------------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-------
K
----
F
-
Y
---
P
E
L
K
L
A
-
Y
A
V
R
G
N
K
L
E
R
G
Q
-
K
-
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
---
F
I
D
P
K
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
--
M
L
----
P
-------
R
N
--
C
--------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
-------------
D
P
N
V
I
K
L
K
R
E
----
E
E
----
T
L
D
T
--
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
T
I
A
-
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
70.03
32%
-119
- C2 -
3FHT
4
DD19B_HUMAN
A:
[26-399]
---
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
E
----
P
A
------------------
N
---------
K
---
Y
---
P
---------
Q
------------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-------
K
----
F
-
Y
---
P
E
L
K
L
A
-
Y
A
V
R
G
N
K
L
E
R
G
Q
-
K
-
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K
---
F
I
D
P
K
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
--
M
L
----
P
-------
R
N
--
C
--------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
-------------
D
P
N
V
I
K
L
K
R
E
----
E
E
----
T
L
D
T
--
I
K
Q
Y
Y
V
L
C
S
-
S
-
R
D
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
T
I
A
-
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
69.84
33%
-120
- C2 -
3FHT
4
DD19B_HUMAN
A:
[24-399]
-
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
-
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
E
----
P
A
------------------
N
---------
K
---
Y
---
P
---------
Q
------------------
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
-
F
----
Y
----
P
E
L
---
K
L
A
Y
A
V
-
R
G
N
K
L
---
E
R
G
Q
-
K
-
I
-
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
-
L
K--
F
I
D
P
K
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
--
M
L
----
P
-------
R
N
--
C
--------
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
-------------
D
P
N
V
I
K
L
K
R
E
----
E
E
----
T
L
D
T
--
I
K
Q
Y
Y
V
L
C
S
-
S
R
D
-
E
-
K
----
F
----
Q
A
L
C
N
L
Y
G
-
A
----------
I
T
I
A
-
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
---
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
------
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
-
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
69.61
37%
-110
- C2 -
4D26
4
?
A:
[51-404]
---
S
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
-
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
-
D
--
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
-
L
L
----
Q
D
------------------
P
---------
K
---
D
---
L
I
S
E
NG
C
A
Q
P
Q
------------------
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
----
S
----
V
-
L
---
K
V
A
V
A
Y
-
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
-
R
-
G
-
C
H
I
L
V
A
T
P
G
R
L
-----
H
D
F
V
-
E
R
-
N
---
R
V
S
F
G
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
M
-
G
-
F
M
P
S
I
E
K
M
M
--
L
--
H
P
----
T
MVET---
T
K
--
R
--------
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
-------------
N
Y
L
F
V
A
V
G
I
V
----
G
G
----
A
S
T
D
--
V
E
Q
I
F
I
E
V
T
-
K
-
Y
-
E
-
K
----
R
----
N
S
L
K
Q
L
I
E
-
E
----------
N
D
G
K
-
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
---
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
68.28
35%
-115
- C2 -
5ELX
7
?
A:
[3-364]
---
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
N
----
P
E
------------------
D
---------
A
---
S
---
P
---------
Q
------------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
----
K
----
I
-
T
---
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
--------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
---
L
M
Q
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
--
F
L
----
P
-------
K
D
--
T
--------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
-------------
N
A
N
T
L
E
L
Q
T
N
----
E
V
----
N
V
D
A
--
I
K
Q
L
Y
M
D
C
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
L
----------
M
T
I
G
-
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.28
35%
-112
- C2 -
3PEY
11
DBP5_YEAST
A:
[4-367]
-
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
N
----
P
E
------------------
D
---------
A
---
S
---
P
---------
Q
------------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
----
K
----
I
-
T
---
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
--------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
---
L
M
Q
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
--
F
L
----
P
-------
K
D
--
T
--------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
-------------
N
A
N
T
L
E
L
Q
T
N
----
E
V
----
N
V
D
A
--
I
K
Q
L
Y
M
D
C
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
L
----------
M
T
I
G
-
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.06
35%
-115
- C2 -
3PEW
9
DBP5_YEAST
A:
[4-367]
-
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
N
----
P
E
------------------
D
---------
A
---
S
---
P
---------
Q
------------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
----
K
----
I
-
T
---
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
--------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
---
L
M
Q
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
--
F
L
----
P
-------
K
D
--
T
--------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
-------------
N
A
N
T
L
E
L
Q
T
N
----
E
V
----
N
V
D
A
--
I
K
Q
L
Y
M
D
C
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
V
----------
M
T
I
G
-
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
65.65
35%
-119
- C2 -
3RRN
2
DBP5_YEAST
A:
[3-367]
M
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
N
----
P
E
------------------
D
---------
A
---
S
---
P
---------
Q
------------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
----
K
----
I
-
T
---
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
--------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
---
L
M
Q
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
--
F
L
----
P
-------
K
D
--
T
--------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
-------------
N
A
N
T
L
E
L
Q
--------------
D
A
--
I
K
Q
L
Y
M
D
C
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
V
----------
M
T
I
G
-
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
64.71
35%
-125
- C2 -
3RRM
1
DBP5_YEAST
A:
[11-367]
---------
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
N
----
P
E
------------------
D
---------
A
---
S
---
P
---------
Q
------------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
----
K
----
I
-
T
---
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
--------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
---
L
M
Q
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
--
F
L
----
P
-------
K
D
--
T
--------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
-------------
N
A
N
T
L
E
L
--------
V
----
N
V
D
A
--
I
K
Q
L
Y
M
D
C
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
V
----------
M
T
I
G
-
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
S
A
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
64.54
35%
-113
- C2 -
3I5X
3
MS116_YEAST
A:
[78-459]
---------
V
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
-
D
--
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
-
L
I
----
N
T
KFDS--------------
Q
---------
Y
---
M
---
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
N---
Y
----
G
-
L
KKY
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
N
K
-
L
-
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
S--
N
K
F
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
S
--
G
--
I
L
----
N
E
K
NSKSA
D
N
--
I
--------
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
-------------
K
K
E
C
L
F
L
D
T
V
DKNE
P
E
----
A
H
E
R
--
I
D
Q
S
V
V
I
S
E
-
K
F
A
-
N
-
S
----
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
---
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
D
----------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
63.25
34%
-110
- C2 -
3SQW
3
MS116_YEAST
A:
[27-409]
---------
V
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
-
D
--
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
-
L
I
----
N
T
KFDS--------------
Q
---------
Y
---
M
---
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
----
N
YGLK
K
-
Y
---
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
N
K
-
L
-
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
S--
N
K
F
F
R
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
S
--
G
--
I
L
----
N
E
K
NSKSA
D
N
--
I
--------
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
-------------
K
K
E
C
L
F
L
D
T
V
----
D
K
NEPE
A
H
E
R
--
I
D
Q
S
V
V
I
S
E
K
F
-
A
-
N
-
S
I
F
A
A
V
----
E
H
I
K
K
Q
I
K
E
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
---
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
---------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
62.21
35%
-104
- C2 -
3PEY
11
DBP5_YEAST
A:
[4-377]
-
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
-
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
N
----
P
E
------------------
D
---------
A
---
S
---
P
---------
Q
------------------
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
----
T
----
K
-
I
---
T
S
Q
L
I
V
-
P
D
S
F
E
----
K
N
K
-
Q
-
I
-
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
-
K
---
L
M
Q
L
Q
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
--
F
L
----
P
-------
K
D
--
T
--------
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
-------------
N
A
N
T
L
E
L
Q
T
N
----
E
V
----
N
V
D
A
--
I
K
Q
L
Y
M
D
C
K
N
E
-
A
-
D
-
K
----
F
----
D
V
L
T
E
L
Y
G
-
L
----------
M
T
I
G
-
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
---
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
-
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
-----------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.28
33%
-106
- C2 -
3I62
4
MS116_YEAST
A:
[79-458]
----------
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
----
T
K
------------------
F
---------
D
---
S
QYM
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
NYGL
K
----
K
-
Y
---
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
-
N
-
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
---
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
---
S
--
G
I
----
L
-------
N
E
--
K
NSKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
KK
E
C
L
F
L
D
TVDKN
E
P
E
A
H
E
R
I
D
Q
----
S
V
----
V
I
S
E
K
F
A
N
S
I
F
A
A
V
E
-
H
-
I
-
K
-
K
-------------
Q
I
K
E
-
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
59.13
33%
-106
- C2 -
3I5X
3
MS116_YEAST
A:
[79-458]
----------
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
----
T
K
------------------
F
---------
D
---
S
QYM
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
NYGL
K
----
K
-
Y
---
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
-
N
-
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
---
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
---
S
--
G
I
----
L
-------
N
E
--
K
NSKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
KK
E
C
L
F
L
D
TVDKN
E
P
E
A
H
E
R
I
D
Q
----
S
V
----
V
I
S
E
K
F
A
N
S
I
F
A
A
V
E
-
H
-
I
-
K
-
K
-------------
Q
I
K
E
-
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
58.41
33%
-104
- C2 -
3I61
4
MS116_YEAST
A:
[79-458]
----------
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
----
T
K
------------------
F
---------
D
---
S
QYM
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
NYGL
K
----
K
-
Y
---
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
-
N
-
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
---
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
---
S
--
G
I
----
L
-------
N
E
--
K
NSKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
KK
E
C
L
F
L
D
TVDKN
E
P
E
A
H
E
R
I
D
Q
----
S
V
----
V
I
S
E
K
F
A
N
S
I
F
A
A
V
E
-
H
-
I
-
K
-
K
-------------
Q
I
K
E
-
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.38
33%
-103
- C2 -
3I5Y
3
MS116_YEAST
A:
[79-458]
----------
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
----
T
K
------------------
F
---------
D
---
S
QYM
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
NYGL
K
----
K
-
Y
---
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
-
N
-
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
---
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
---
S
--
G
I
----
L
-------
N
E
--
K
NSKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
KK
E
C
L
F
L
D
TVDKN
E
P
E
A
H
E
R
I
D
Q
----
S
V
----
V
I
S
E
K
F
A
N
S
I
F
A
A
V
E
-
H
-
I
-
K
-
K
-------------
Q
I
K
E
-
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.34
33%
-101
- C2 -
3SQX
3
MS116_YEAST
A:
[28-407]
----------
L
D
K
E
I
H
K
A
I
-
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
----
T
K
------------------
F
---------
D
---
S
QYM
V
---------
K
------------------
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
NYGL
K
----
K
-
Y
---
A
C
V
S
L
V
-
G
G
T
D
F
R
A
A
M
N
K
M
-
N
-
K
L
R
-
P
N
I
V
I
A
T
P
G
R
L
-----
I
D
V
L
-
E
K
-
Y
---
S
N
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
I
-
G
-
F
R
D
D
L
E
T
I
---
S
--
G
I
----
L
-------
N
E
--
K
NSKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
KK
E
C
L
F
L
D
TVDKN
E
P
E
A
H
E
R
I
D
Q
----
S
V
----
V
I
S
E
K
F
A
N
S
I
F
A
A
V
E
-
H
-
I
-
K
-
K
-------------
Q
I
K
E
-
R
----------
D
S
N
Y
-
K
-
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
F
K
K
---
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
R
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.21
44%
-143
- C2 -
3NBF
2
?
D:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
56.62
45%
-140
- C2 -
2GXS
3
?
A:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
55.90
45%
-137
- C2 -
2GXQ
2
?
A:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
55.68
34%
-150
- C2 -
1T6N
1
DX39B_HUMAN
A:
[16-220]
----
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
-
D
--
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
-
L
E
----
P
V
------------------
T
---------
G
---
Q
---
V
---------
S
------------------
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
-
Y
M---
P
----
N
-
V
---
K
V
A
V
F
F
-
G
G
L
S
I
K
K
D
E
E
V
L
-
K
-
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
-
K
---
S
L
N
L
K
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
--
R
--
M
T
----
P
-------
H
E
--
K
--------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
-------------
D
P
M
E
I
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
55.42
44%
-135
- C2 -
3NBF
2
?
A:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
55.14
45%
-137
- C2 -
2GXS
4
?
B:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
55.09
44%
-144
- C2 -
3MWL
2
?
B:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
54.75
44%
-136
- C2 -
3NBF
4
?
C:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RG
R
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
54.03
34%
-149
- C2 -
1T6N
1
DX39B_HUMAN
B:
[16-220]
----
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
-
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
-
D
--
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
-
L
E
----
P
V
------------------
T
---------
G
---
Q
---
V
---------
S
------------------
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
-
Y
M---
P
----
N
-
V
---
K
V
A
V
F
F
-
G
G
L
S
I
K
K
D
E
E
V
L
-
K
-
K
-
N
C
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
-
K
---
S
L
N
L
K
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
L
-
D
-
M
R
R
D
V
Q
E
I
F
--
R
--
M
T
----
P
-------
H
E
--
K
--------
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
-------------
D
P
M
E
I
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
53.73
36%
-147
- C2 -
4PX9
1
DDX3X_HUMAN
C:
[66-284]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
LRAMKENGRYGRRKQYPI
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
QD
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
53.62
36%
-148
- C2 -
4PX9
1
DDX3X_HUMAN
A:
[66-284]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
LRAMKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
QD
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
53.42
36%
-147
- C2 -
4PX9
1
DDX3X_HUMAN
B:
[66-284]
---
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
-
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
Y
----
S
D
------------------
G
---------
P
---
G
---
E
---------
A
LRAMKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
----
S
----
R
-
V
---
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
-
R
-
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
-
G
---
K
I
G
L
D
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
QD
T
M
----
P
-------
P
K
GV
R
--------
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
-------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
53.34
44%
-135
- C2 -
3MWK
2
?
B:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
53.12
37%
-145
- C2 -
3FE2
3
DDX5_HUMAN
A:
[28-239]
-
V
L
N
F
Y
E
-
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
-
D
--
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
-
I
N
-----
H
------------------
Q
---------
P
---
F
---
L
---------
E
RGDGPI------------
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
-
A
----
C
----
R
-
L
---
K
S
T
C
I
Y
-
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
-
R
-
G
-
V
E
I
C
I
A
T
P
G
R
L
-----
I
D
F
L
-
E
C
-
G
---
K
T
N
L
R
R
-
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
K
I
V
--
D
--
Q
I
----
R
-------
P
D
--
R
--------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
-------------
D
Y
I
H
I
N
I
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
53.07
44%
-130
- C2 -
3NBF
2
?
B:
[3-205]
----
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
-
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
----
P
S
------------------
Q
---------
E
RGR
K
---
P
---------
R
------------------
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
-------
P
----
H
-
L
---
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
-
R
-
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
-
G
---
V
L
D
L
S
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
--
A
T
----
P
-------
P
S
--
R
--------
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
-------------
N
P
V
L
I
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
52.57
37%
-161
- C2 -
3IUY
2
DDX53_HUMAN
A:
[18-228]
-
T
C
R
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
-
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
--
G
--
I
-
D
--
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
-
L
D
-----------------------------------------------------NGPG--------------
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
K
Y
S
Y
------
K
----
G
-
L
---
K
S
I
C
I
Y
-
G
------
Q
I
E
D
I
-
S
-
K
-
G
-
V
D
I
I
I
A
T
P
G
R
L
-----
N
D
L
Q
-
M
N
-
N
---
S
V
N
L
R
S
-
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
M
-
E
-
F
E
P
Q
I
R
K
I
L
--
L
--
D
V
----
R
-------
P
D
--
R
--------
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
-------------
D
P
M
I
V
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
52.49
37%
-140
- C2 -
3FE2
4
DDX5_HUMAN
B:
[28-239]
-
V
L
N
F
Y
E
-
A
N
F
P
A
N
V
M
D
V
I
-
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
-
D
--
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
-
I
N
-----
H
------------------
Q
---------
P
---
F
---
L
---------
E
RGDGPI------------
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
-
A
----
C
----
R
-
L
---
K
S
T
C
I
Y
-
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
-
R
-
G
-
V
E
I
C
I
A
T
P
G
R
L
-----
I
D
F
L
-
E
C
-
G
---
K
T
N
L
R
R
-
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
M
-
G
-
F
E
P
Q
I
R
K
I
V
--
D
--
Q
I
----
R
-------
P
D
--
R
--------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
-------------
D
Y
I
H
I
N
I
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.13
37%
-155
- C2 -
3IUY
2
DDX53_HUMAN
B:
[18-228]
-
T
C
R
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
-
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
--
G
--
I
-
D
--
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
-
L
D
----
S
------------------------------------------------NGPG--------------
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
K
Y
S
Y
------
K
----
G
-
L
---
K
S
I
C
I
Y
-
G
------------------
V
D
I
I
I
A
T
P
G
R
L
-----
N
D
L
Q
-
M
N
-
N
---
S
V
N
L
R
S
-
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
M
-
E
-
F
E
P
Q
I
R
K
I
L
--
L
--
D
V
----
R
-------
P
D
--
R
--------
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
-------------
D
P
M
I
V
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
51.03
33%
-157
- C2 -
2OXC
1
DDX20_HUMAN
B:
[26-228]
----
F
E
S
-
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
-
D
--
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
V
----
L
E
------------------
N
---------
L
---
S
---
T
---------
Q
------------------
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
----
M
----
E
-
G
---
L
E
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
-
C
--
H
I
A
V
G
S
P
G
R
I
KQLIE
L
D
Y
L
-
N
P
-
G
---
S
I
R
L
------
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
--
S
L
----
P
-------
A
S
--
K
--------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
-------------
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
50.26
33%
-152
- C2 -
2OXC
1
DDX20_HUMAN
A:
[26-228]
----
F
E
S
-
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
-
D
--
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
V
----
L
E
------------------
N
---------
L
---
S
---
T
---------
Q
------------------
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
----
M
----
E
-
G
---
L
E
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
-
C
--
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
Y
L
-
N
P
-
G
---
S
I
R
L
------
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
--
S
L
----
P
-------
A
S
--
K
--------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
-------------
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
50.24
33%
-152
- C2 -
3B7G
1
DDX20_HUMAN
A:
[26-228]
----
F
E
S
-
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
-
D
--
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
V
----
L
E
------------------
N
---------
L
---
S
---
T
---------
Q
------------------
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
----
M
----
E
-
G
---
L
E
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
-
C
--
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
Y
L
-
N
P
-
G
---
S
I
R
L
------
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
--
S
L
----
P
-------
A
S
--
K
--------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
-------------
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
50.04
38%
-135
- C2 -
3BER
4
DDX47_HUMAN
A:
[42-249]
-
T
K
T
F
K
D
-
L
G
V
T
D
V
L
C
E
A
C
-
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
--
G
--
R
-
D
--
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
-
L
L
----
E
T
------------------
P
---------
Q
---
R
---
L
---------
F
------------------
A
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
-
S
----
I
----
G
-
V
---
Q
S
A
V
I
V
-
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
-
K
-
K
-
P
H
I
I
I
A
T
P
G
R
L
-----
I
D
H
L
E
N
T
-
K
---
G
F
N
L
R
A
-
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
M
-
D
-
F
E
T
E
V
D
K
I
L
--
K
--
V
I
----
P
-------
R
D
--
R
--------
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
-------------
N
P
V
K
C
A
V
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
49.21
39%
-133
- C2 -
2PL3
6
DDX10_HUMAN
A:
[27-234]
----
F
S
D
-
F
P
L
S
K
K
T
L
K
G
L
-
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
-
D
--
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
-
L
Y
R
L
QW
T
S
------------------
T
---------
D
---
G
---
L
---------
G
------------------
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
-
N
----
H
----
D
-
F
---
S
A
G
L
I
I
-
G
G
--
L
K
H
E
A
E
R
I
-
N
---
N
-
I
N
I
L
V
C
T
P
G
R
L
-----
L
Q
H
M
-
D
E
-
T
V--
S
F
H
A
T
D
-
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
M
-
G
-
F
A
D
T
M
N
A
V
I
--
E
--
N
L
----
P
-------
K
K
--
R
--------
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
-------------
N
P
E
Y
V
W
V
H
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
49.02
33%
-154
- C2 -
3B7G
1
DDX20_HUMAN
B:
[26-228]
----
F
E
S
-
L
L
L
S
R
P
V
L
E
G
L
-
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
-
D
--
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
V
----
L
E
------------------
N
---------
L
---
S
---
T
---------
Q
------------------
I
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
----
M
----
E
-
G
---
L
E
C
H
V
F
I
G
G
T
P
L
S
Q
D
K
T
R
L
-
K
-
K
-
C
--
H
I
A
V
G
S
P
G
R
I
KQLIE
L
D
Y
L
-
N
P
-
G
---
S
I
R
L
------
F
I
L
D
E
A
D
K
L
L
-
E
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
--
S
L
----
P
-------
A
S
--
K
--------
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
-------------
D
P
T
F
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------