@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu04860: (2016-06-08 )
MSDFLNKRFWKYRGKRIRPYMRNNVKLAGAIIFVPVFLLSMFLFWREQLIHFDLSQVIKNFEWNVPLIIKSVLCSVLIAVGSIVASYFLLFDSYKKILHRQKIAKMIFSNKFYEKENVKVRKIFSNETDSKEKITYFPRMYYQVKNNHIYIRIAMDMSRFQNRFLDLGKDLENGLFCDLVDKQMEEGFVCFKLLYDVKKNRISIDDAVAENGVLPLMKHISWQFDKLPHMLIAGGTGGGKTYFMLTIIKACVGLGADVRILDPKNADLADLEEVLPKKVYSQKNGILMCLRKSVDGMMERMDEMKQMSNYKTGENYAYLGLKPVFIFFDEYVAFMDLLDMKERNEALSYMKQLVMLGRQAGYFLVLGAQRPDAKYLADGIRDQFSFRVSLGLMSDTGYGMMFGDVEKAYVNKKETGRGYANVGTGSVLEFYSPIVPKGYDFMSSIKNALVGVEGAQATAVASGSVSDQTASGEGVSEANG
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60.......------.70..-......80........-90........100.......110.......120.......-130.......140.......150....-...160.......170........180.---......190.----......200.......--------210..---------..-------.----------..220.....---.------...230.......240----.......250--..----.....--260-.-------------------...-.-----...---270..--..--.---..280-----..--.---.----...---..290-------------........300....--..---------.------310....-------.-----------------------------..320.----------------------------..-------------------....330.......340---.---.....-..350.....--..360.......370..-----.----....380--...-...-..390.......400--........-410...---..-...420--..-.....430.......440....-----..-..450.......460....-...470..-------.....480------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
D
F
L
N
K
R
F
W
K
YRG
K
R
I
R
P
Y
MRNN
V
K
L
A
G
A
I
I
F
V
P
V
F
L
L
S
M
F
L
F
W
R
E
Q
L
I
H
F
D
L
S
Q
V
I
K
NFEWN
V
P
L
I
------
I
K
S
V
L
-
C
S
V
L
I
A
V
G
S
I
V
A
S
Y
F
L
-
L
F
D
S
Y
K
K
I
L
H
R
Q
K
I
A
K
M
I
F
SNKFYEKEN
V
K
V
R
K
I
FSNETD-SKE
K
I
T
YF
P
R
M
Y
Y
Q
VKN
N
H
I
Y
I
R
I
AM
D
-
M
S
R
F
Q
N
R
F
L
D
L
G
K
D
-LENG
L
F
C
D
L
V
D
K
Q
---
M
E
E
G
F
V
C
F
K
L
----
L
Y
D
V
KKNRISI
D
D
A
V
A--------EN
G
V
L
---------
P
L
-------
M
----------
K
H
I
--
S
W
Q
F
D---K------LP
H
M
L
I
AGGTGG
G
K
T
Y
----
F
M
L
T
I
I
K
A
C
V--GL----GA
D
V
R
--
I
L--D-------------------PKN-A-----
D
L
A
---
D
L
E
E
V
--
L
P
--
K
---
K
V
Y-------SQ--K---N----
G
I
L
---
M
C
L
R
--------------
K
S
V
D
G
M
M
E
R
M
D
E
M
K
Q
--
M
S---------N------YKTGE
N
Y
-------
A
-----------------------------
Y
LG
L
K
P
----------------------------
V
F
-------------------
I
F
F
D
E
Y
V
A
F
M
D
L
L
D
M
-
K
---
E
---
R
N
E
A
L
-
S
Y
M
K
Q
L
V
M
L
G--RQA
G
Y
F
L
V
L
GAQRP
D
A
K
-----
Y
----
L
A
D
G
I
R
---
D
Q
F
-
S
F
R
-
V
S
L
G
LMSDTGYG
M
M
---FG
D
V
E
K
A
Y
-VN-KKE---TG-RGYANV--GT-
G
S
V
L
E
F
YSPIVPK
G
Y
D
-
F
M
S
S
I
-----
K
N
-
A
L
VGVEGA
Q
A
T
A
V
ASGSVS-DQTASGEG-------VSEANG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
78.72
17%
-115
- C2 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
----
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
------
V
K
V
S
R
-
I
S
N
L
-----------------------
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
-
N
E
-------------
D
R
Q
M
V
R
F
S
E
V
L
S
-
S
P
E
Y
D
E
H
K
S
T
V
--------------------------
P
L
A
L
----
G
H
D
I
G
G
R
P
I
I
T
D
------------------------------------------------------
L
A
---
K
------
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
----
G
V
N
A
M
L
L
S
I
L
F
K
S
T
----
P
S
E
A
R
--
L
I
M
I
D
-------------------
P
K
M
-
L
-----
E
L
S
---
I
Y
E
G
I
PH
L
L
--
C
---
P
V
V
-------
T
D
--
M
---
K
----
E
A
A
---
N
A
L
R
--------------
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
--
M
G
---------
V
------
R
N
L
A
G
F
N
-------
R
-----------------------------
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQL
S
T
L
P
T
I
V
-------------------
V
V
V
D
E
F
A
D
M
M
M
I
--------
V
---
G
K
K
V
E
-
E
L
I
A
R
I
A
Q
K
A
--
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-----
V
----
I
T
G
L
I
K
---
A
N
I
-
P
T
R
-
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
---
L
D
Q
----------------
G
-
G
A
E
Q
L
L
--
G
H
-
G
D
M
L
Y
L
-----
P
P
G
T
G
-
L
P
I
R
V
-----
H
G
-
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
-
A
P
D
Y
I
E
D
I
-------
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.41
25%
0
- C- -
4NH0
1
?
A:
[274-559]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
N
R
L
R
V
P
I
G
L
D
--------
A
D
G
-
R
---------
P
L
-------
E
----------
L
D
I
KE
S
A
Q
G
G
---
M
------
G
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
----
L
L
R
T
L
V
L
A
-
L
--
A
M
----
T
H
S
P
E
--
V
L
--
N
F
V
L
V
D
FKGGATFLGMEGLR
H
V
S
-
A
-----
I
I
T
---
N
L
E
E
E
--
L
P
L
V
D
---
R
M
Y
-------
D
A
--
L
---
H
----
G
---------------------------
E
M
V
R
R
Q
E
H
L
R
H
--
S
G
---------
N
------
Y
A
S
L
R
D
Y
E
K
A
R
M
E
G
A
-----------------------------
P
L
P
P
M
P
T
---------------------------
L
F
-------------------
I
V
L
D
E
---
F
S
E
L
L
S
A
-
K
---
P
---
D
F
A
E
L
-
F
V
M
--
I
G
R
L
G
--
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
E
G
-----
K
----
L
R
-
G
L
D
---
T
H
L
-
S
Y
R
-
I
G
L
R
T
F
S
A
M
E
S
R
V
V
---
L
G
-
V
P
D
A
Y
-
E
L
-
P
P
S
---
P
G
-
N
G
Y
L
K
F
--
A
T
-
E
P
L
V
R
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
77.42
19%
-139
- C2 -
2IUT
3
FTSK_PSEAE
A:
[120-464]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
F
E
I
Q
P
A
-
A
G
V
K
V
S
R
I
S
N
L
A
K
D
-
L
A
R
S
L
A
V
I
S
V
R
V
V
EVI
P
G
K
T
T
V
G
I
E
I
----
P
N
E
-
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
--
H
K
S
T
V
---------
P
L
ALGHDIG
G
----------
R
P
I
--
I
T
D
L
A
---
K
------
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
----
G
V
N
A
M
L
L
S
I
L
--
F
K
STPS
E
A
R
L
I
--
M
I
--
D
-------------------
P
K
M
-
L
-----
E
L
S
---
I
Y
E
G
I
--
P
H
LL
C
---
P
V
V
-------
T
D
--
M
---
K
----
E
A
A
---
N
A
L
R
--------------
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
--
M
----------
G
------
V
R
N
L
A
G
F
-------
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQ
L
S
T
L
P
T
----------------------------
I
V
-------------------
V
V
V
D
E
F
A
D
M
M
M
I
V
-----------
G
K
K
V
E
-
E
L
I
A
R
I
A
Q
K
A
--
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-----
V
----
I
T
G
L
I
K
---
A
N
I
-
P
T
R
-
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
---
L
D
Q
G
G
A
E
---
Q
-
L
L
G
---
H
G
-
D
M
L
Y
L
P
--
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
------
D
E
V
-----
H
R
-
V
V
E
A
W
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
77.17
17%
-133
- C2 -
2IUS
-
FTSK_ECOLI
A:
[890-1238]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
F
E
L
N
L
A
-
P
G
V
K
A
A
R
I
S
N
L
S
R
D
-
L
A
R
S
L
S
T
V
A
V
R
V
V
EVI
P
G
K
P
Y
V
G
L
E
L
----
P
N
K
-
K
R
Q
T
V
Y
L
R
E
V
L
D
N
A
K
F
R
D
NP
S
P
L
T
V
---------
V
L
-------
G
KDIAG-----
E
P
V
--
V
A
D
L
A
---
K
------
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
----
G
V
N
A
M
I
L
S
M
L
--
Y
K
AQPE
D
V
R
F
I
--
M
I
--
D
-------------------
P
K
M
-
L
-----
E
L
S
---
V
Y
E
G
I
--
P
H
LL
T
---
E
V
V
-------
T
D
--
M
---
K
----
D
A
A
---
N
A
L
R
--------------
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
A
--
L
----------
G
------
V
R
N
L
A
G
Y
-------
N
E
K
I
A
E
A
D
R
M
MRPIPDPYWH
P
V
--------
L
K
K
E
P
Y
----------------------------
I
V
-------------------
V
L
V
D
E
F
A
D
L
M
M
T
V
-----------
G
K
K
V
E
-
E
L
I
A
R
L
A
Q
K
A
--
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
-----
V
----
I
T
G
L
I
K
---
A
N
I
-
P
T
R
-
I
A
F
T
V
S
S
K
I
D
S
R
T
I
---
L
D
Q
A
G
A
---
E
S
-
L
L
G
---
M
G
-
D
M
L
Y
S
G
--
P
N
S
T
L
P
V
R
V
H
G
A
F
V
R
D
------
Q
E
V
-----
H
A
-
V
V
Q
D
W
K
A
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
66.94
15%
-144
* C2 *
4LYA
1
?
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
L
P
P
R
L
A
R
P
A
S
V
T
A-------
E
A
N
A
F
---------
P
I
-------
G
L
K
D
E
PELQ
S
Q
S
D
Y
--
F
Y
Q
W
L
---
E
------
D
G
N
I
G
I
F
G
S
A
G
Y
G
K
S
T
----
T
M
M
T
L
L
L
S
F
A
--
G
A
Y
NPA
Q
L
H
Y
Y
--
I
F
--
D
-------------------
F
G
N
-
S
-----
A
L
L
---
P
L
R
Q
L
--
P
H
T-
A
---
D
Y
F
R
L-----
D
D
--
E
---
K
----
K
I
E
---
K
F
I
K
--------------
F
M
K
E
E
M
E
Q
R
K
Q
R
F
M
E
--
K
----------
E
------
V
S
T
I
K
L
Y
-------
N
A
L
S--------------------------
E
E
K
L
P
I
----------------------------
I
I
-------------------
V
A
L
D
N
F
D
V
V
K
E
E
M
------------
P
D
F
E
-
T
Q
L
I
Q
Y
A
R
D
G
--
Q
S
L
G
I
F
F
I
M
T
A
T
R
V
--
S
-----
G
----
I
R
P
P
L
M
---
N
N
L
-
K
T
K
-
I
V
H
Y
F
I
D
S
S
E
K
F
S
L
---
I
G
R
T
P
Y
---
D
V
-
D
P
I
---
P
G
-
R
A
L
I
K
K
--
D
N
---
A
A
L
T
Q
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.21
23%
-161
- C2 -
2IUS
-
FTSK_ECOLI
A:
[983-1182]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
----
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
----
P
E
D
V
R
F
I
M
I
--
D
-------------------
P
K
M
-
L
-----
E
L
S
VYE
G
I
P
H
L
--
L
T
--
E
---
V
V
T
-------
D
M
--
K
D
A
A
N
----
A
L
R
---
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
A
L
GV
R
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
--
M
M
---------
R
PIPDPY
W
-----
H
-------
P
-----------------------------
V
L
K
K
E
P
Y
---------------------------
I
V
-------------------
V
L
V
D
E
F
A
D
L
M
--
M
T
V
-
G
---
K
---
K
V
E
E
L
---
I
A
R
L
A
Q
K
A
--
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
-----
V
----
I
T
G
L
I
K
---
A
N
I
-
P
T
R
-
I
A
F
T
V
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
63.07
19%
-88
- C2 -
4NH0
5
?
A:
[246-1147]
SANMT
L
T
S
L
L
HIDNPYNLD
P
A
V
L
W
RPRPQRNRLRVPIGLDADG
R
P
L
E
L
D
IKESAQGGMGP
H
G
L
C
I
G
A
TGSG
K
S
E
L
L
R
T
L
V
L
A
L
A
M
T
H
SPEV
L
N
F
V
L
V
D
FKGGATFLGMEGLRHVS
A
I
I
T
NLEEELP
L
V
D
R
M
Y
D
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
S
GNYAS
L
R
D
Y
E
K
A
R
M
E
G
A
P
L
P
P
M
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
K
------
P
D
F
A
E
L
F
V
M
I
G
R
L
G
R
S
L
-
G
V
H
L
L
L
A
S
------
Q
R
L
E
E
G
K
L
R
G
L
D
T
H
L
S
Y
R
I
G
L
R
------
T
F
S
A
M
-
E
S
R
V
V
----------
L
-
G
V
P
D
A
Y
E
L
P
P
S
P
G
N
G
Y
L
K
F
A
T
E
----
P
L
V
R
F
K
A
A
Y
V
S
G
P
V
-
D
E
E
S
E
S
L
F
D
V
V
V
R
Q
L
A
G
H
G
P
------
E
-
P
H
Q
I
W
L
P
P
L
D
V
P
P
T
-
L
D
E
L
L
--
P
P
L
S
P
S
---
A
A
H
G
Y
T
A
---------
D
G
W
E
W
R
G
R
L
H
A
V
V
G
--------
L
V
D
R
P
---------
F
D
-------
Q
----------
R
R
D
--
P
Y
W
L
D
LSG
G
------
A
G
H
V
G
V
A
G
G
P
Q
T
G
K
S
T
----
M
L
R
T
L
I
T
S
L
A
--
L
L
H
TPQ
E
V
Q
F
Y
--
C
L
--
D
-------------------
F
G
G
-
G
-----
T
L
A
---
G
L
A
E
---
L
P
HV
G
---
S
V
A
-------
T
R
LD
A
---
D
----
R
I
R
---
R
T
V
A
--------------
E
V
S
A
L
L
E
Q
R
E
Q
E
F
T
E
R
G
I
D
---------
S
------
M
A
T
Y
R
R
L
-------
R
-----------------------------
A
T
G
E
Y
A
----------------------------
G
D
-------------------
G
F
G
D
V
F
L
V
V
D
N
W
L
T
L
-
R
---
Q
---
D
Y
E
A
L
E
D
S
I
T
Q
L
A
A
R
G
--
L
G
Y
G
I
H
V
V
L
S
S
N
K
--
W
S
-----
E
----
F
R
T
S
I
R
---
D
L
L
-
G
T
K
-
L
E
L
R
L
G
D
P
Y
E
S
E
V
------
D
R
K
K
A
A
N
V
P
-
E
N
R
---
P
G
-
R
G
L
------------------
T
R
D
G
Y
H
-
F
L
T
A
L
PRIDG
D
T
-
S
A
E
T
L
T
E
G
I
A
T
T
V
K
T
I
R
E
A
-
W
H
G
P
T
A
P
P
-------
V
R
M
L
P
N
VLPAAQLPSAAESGTRIPIGIDEDSL
S
P
V
Y
L
D
FNTDP
H
F
L
V
F
G
D
T
ECG
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
Y
TPQQ
A
R
L
I
F
IDYSRSLLDVATTEHQIGYAAS
S
T
A
A
S
S
L
V
R
D
I
K
G
A
M
E
A
R
LPPPDLT
P
E
Q
L
R
S
RSW
W
T
G
A
E
L
F
L
V
V
D
DYEMVATSDNPLRPLAELLPQARDIG
L
H
L
I
I
A
R
S
MGGAGRALYE
P
I
I
Q
R
I
K
E
M
A
S
P
G
L
V
M
S
GNKDEGILLGN
V
K
P
H
KLPQG
R
G
Y
F
V
E
RRS
G
T
R
L
I
Q
T
A
Y
R
E
S
3
PsiBlast_PDB
61.59
23%
-162
- C2 -
2IUT
2
FTSK_PSEAE
A:
[205-411]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
I
--
I
T
D
L
A
---
K
------
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
--
P
S
----
E
A
R
L
I
--
M
I
--
D
-------------------
P
K
M
-
L
-----
E
L
S
----
I
Y
E
G
--
I
P
--
H
LLC
P
V
V
-------
T
D
--
M
---
K
----
E
A
A
---
N
A
L
R
--------------
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
--
M
G
VRN
L
A
G
F
N
R
K
------
V
K
D
A
E
E
A
-------
G
-----------------------------
T
P
L
T
D
P
----------------------------
L
F
RRESPDDEPPQL
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
--
K
---
K
---
V
E
E
L
I
-
A
R
I
A
Q
---
K
A
--
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-----
V
----
I
T
G
L
I
K
---
A
N
I
-
P
T
R
-
I
A
F
Q
V
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.70
23%
-152
- C2 -
2IUU
1
FTSK_PSEAE
A:
[205-411]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
I
--
I
T
D
L
A
---
K
------
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
--
P
S
----
E
A
R
L
I
--
M
I
--
D
-------------------
P
K
M
-
L
-----
E
L
S
----
I
Y
E
G
--
I
P
--
H
LLC
P
V
V
-------
T
D
--
M
---
K
----
E
A
A
---
N
A
L
R
--------------
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
--
M
G
VRN
L
A
G
F
N
R
K
------
V
K
D
A
E
E
A
-------
G
-----------------------------
T
P
L
T
D
P
----------------------------
L
F
RRESPDD
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
--
K
---
K
---
V
E
E
L
I
-
A
R
I
A
Q
---
K
A
--
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-----
V
----
I
T
G
L
I
K
---
A
N
I
-
P
T
R
-
I
A
F
Q
V
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
59.64
18%
-137
- C2 -
4LYA
2
?
A:
[348-558]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
V
--
A
I
N
M
R
---
T
------
D
P
H
C
L
I
V
G
Q
S
R
K
G
K
T
N
----
V
V
K
V
I
L
E
S
L
L
--
V
Q
E---
P
E
S
I
G
--
L
L
--
D
-------------------
G
I
D
-
R
-----
G
L
A
---
G
Y
A
N
R
--
D
D
--
I
---
T
Y
I
-------
E
A
--
K
---
E
----
R
L
A
---
Q
W
L
N
--------------
E
A
D
A
V
L
Q
Q
R
E
R
E
Y
I
Q
--
A
V
---------
N
-----------------------------------------------------
W
P
P
----------------------------
V
V
-------------------
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
-----------
S
I
M
Q
-
G
R
I
A
N
M
M
K
Q
Y
--
S
H
L
G
F
H
V
F
V
A
G
N
A
N
E
F
V
-----
K
GFD
A
L
T
A
E
L
K
---
Q
I
----
R
-
Q
A
I
-
L
V
T
K
K
S
E
Q
S
L
---
F
A
L
P
F
T
R
N
-
E
Q
-
E
I
E
---
P
G
-
F
G
Y
F
V
V
--
G
G
--
K
D
Q
K
I
Q
I
P
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
59.56
21%
0
- C- -
4NH0
1
?
A:
[289-569]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
L
--
E
L
D
I
K
---
E
SAQGGM
G
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
----
L
L
R
T
L
V
L
A
L
A
--
M
T
H
SPE
V
L
N
F
V
--
L
V
--
D
-------------------
F
K
G
G
A
-----
T
F
L
---
G
M
E
G
L
--
R
H
V-
S
---
A
I
I
-------
T
N
--
L
---
E
EELP
L
V
D
---
R
M
Y
D
--------------
A
L
H
G
E
M
V
R
R
Q
E
H
L
R
H
--
S
G
---------
N
------
Y
A
S
L
R
D
Y
-------
E
K
A
R
M
E
G
A
P
---------------------
L
P
P
M
P
T
----------------------------
L
F
-------------------
I
V
L
D
E
F
S
E
L
L
S
A
K
------------
P
D
F
A
-
E
L
F
V
M
I
G
R
L
G
--
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
E
G
-----
K
----
L
-
R
G
L
D
---
T
H
L
-
S
Y
R
-
I
G
L
R
T
F
S
A
M
E
S
R
V
V
---
L
G
V
P
D
A
Y
E
-
L
P
-
P
-
S
---
P
G
-
N
G
Y
L
K
F
--
A
T
-
E
P
L
V
R
F
K
A
A
Y
V
S
G
P
V
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
55.94
17%
-132
- C2 -
4NH0
2
?
A:
[932-1147]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
--
Y
L
D
F
N
---
T
------
D
P
H
F
L
V
F
G
D
T
E
C
G
K
S
N
----
L
L
R
L
I
T
A
G
I
I
--
E
R
Y
TPQ
Q
A
R
L
I
--
F
I
--
D
-------------------
Y
S
R
-
S
------
L
L
---
D
V
A
T
T
--
E
H
Q-
I
---
G
Y
A
-------
A
S
--
S
---
T
----
A
A
S
---
S
L
V
R
--------------
D
I
K
G
A
M
E
A
R
L
P
P
P
D
L
--
T
-----------------
P
E
Q
L
R
S
R
-------
S
-----------------------------
W
W
T
G
A
E
----------------------------
L
F
-------------------
L
V
V
D
D
Y
E
M
V
A
T
S
-------------
D
N
P
L
-
R
P
L
A
E
L
L
P
Q
A
--
R
D
I
G
L
H
L
I
I
A
R
S
M
G
G
A
G
RALYE
P
----
I
I
Q
R
I
K
---
E
M
A
-
S
P
G
-
L
V
M
S
--
G
N
K
D
E
G
I
L
---
L
G
N
V
K
----
P
H
-
K
L
P
---
Q
G
-
R
G
Y
F
V
E
--
R
R
-
S
G
T
R
L
I
Q
T
A
Y
R
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
53.02
10%
-145
- C2 -
4KFU
6
?
A:
[3-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
D
D
I
V
V
L
V
G
R
K
K
S
G
K
S
Y
----
L
I
K
H
Y
F
I
P
V
L
--
K
A
----
H
K
I
S
Y
--
I
I
--
D
-------------------
D
H
N
-
L
LRSGS
E
Y
S
---
K
F
G
Y
N
--
A
T
S
L
S
---
D
I
V
S
KQ
Y
V
V
V
Y
D
--
R
---
A
----
K
N
D
---
D
F
F
------------------
E
K
L
W
Q
A
S
K
------------------------------
L
-------
H
-----------------------------
S
K
K
Y
G
T
----------------------------
T
V
-------------------
L
I
I
D
E
A
Y
Y
H
F
K
Y
K
------------
Q
K
V
T
-
P
A
I
D
E
A
L
H
A
N
--
R
H
A
G
L
G
L
I
L
S
T
Q
R
V
--
Y
-----
D
----
L
M
P
I
V
Y
---
K
Q
A
-
D
L
I
-
I
M
F
Y
T
R
E
P
N
E
L
R
W
I
S
K
Y
I
S
A
E
A
A
E
K
-
V
K
-
T
L
K
---
Q
Y
-
H
F
L
I
Y
D
--
V
N
S
Q
T
I
K
I
H
K
P
I
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
51.27
18%
-160
- C2 -
1XWI
2
VPS4B_HUMAN
A:
[45-189]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
G
I
L
L
F
G
P
P
G
T
G
K
S
Y
----
L
A
K
A
V
A
T
E
A
N
--
N
------
S
T
F
F
--
S
I
--
S
-------------------
S
S
D
--------
L
-----------
V
S
------
K
W
L
---------------
G
----
E
S
E
---
K
L
V
K
--------------
N
L
F
Q
L
A
--------------------------------------------------------------------------
R
E
N
K
P
----------------------------
S
I
-------------------
I
F
I
D
E
I
D
S
L
C
G
S
R
S
E
-
N
---
E
SEA
A
R
R
I
K
-
T
E
F
L
V
Q
M
Q
G
V
GV
D
N
D
G
I
L
V
L
G
A
T
N
I
P
--
W
-----
V
----
L
D
S
A
I
R
---
R
R
F
-
E
K
R
-
I
Y
I
P
L
P
E
P
H
A
R
A
A
M
---
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
50.39
11%
-74
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[1-490]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
W
D
T
K
F
L
K
K
G
Y
T
----------
F
D
D
V
L
L
I
P
A
E
S
H
V
L
P
N
E
V
D
L
K
-
T
K
L
A
D
N
L
T
L
N
I
P
I
I
T
A
AMDT
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
R
S
E
N
G
V
I
I
D
P
F
F
L
T
--
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
T
L
A
N
R
K
L
V
G
I
I
T
N
R
D
M
R
-
F
I
S
D
Y
N
A
P
I
S
E
H
M
T
S
E
H
L
V
T
A
A
V
G
T
D
---
L
E
T
A
E
R
I
L
H
E
H
RIE
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
--------
I
K
D
I
E
---------
K
V
-------
I
----------
E
F
P
--
H
A
A
K
D
---
E
------
F
G
R
L
L
V
A
A
A
V
G
V
T
S
D
------
T
F
E
R
A
E
A
L
F
--
E
A
----
G
A
D
A
I
--
V
I
--
D
-------------------
T
A
H
-
G
-----
H
S
A
---
G
V
L
R
K
--
I
A
--
E
---
I
R
A
-------
H
F
--
P
---
N
----
R
T
L
---
I
A
G
N
--------------
I
A
T
A
E
G
A
R
A
L
Y
D
-------------------------
A
G
V
D
V
-------
V
-----------------------------
K
V
G
I
G
P
----------------------------
G
S
-------------------
I
C
T
T
R
V
V
A
--------
G
---
V
---
G
V
P
Q
V
-
T
A
I
Y
D
A
A
A
V
A
--
R
E
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
-----
D
----
I
V
K
A
L
A
A
GG
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
---
Q
G
R
K
Y
K
T
Y
-
R
G
M
G
S
I
---
A
A
M
K
K
N
K
L
V
PE
G
I
-
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
-----
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
H
E
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
PHDVQI
T
N
E
A
P
N
YS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
50.37
18%
-182
- C2 -
4LCB
1
?
A:
[129-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
------
P
R
G
I
L
L
Y
G
P
P
G
N
G
K
T
M
----
L
A
A
A
V
A
N
E
I
D
---------
S
Y
F
I
--
H
V
--
D
-------------------
A
A
S
--------
I
-----------
M
S
--
K
-----
G
-------
E
A
--
E
---
K
----
N
V
A
---
K
I
F
N
--------------
T
A
R
----
E
Y
----------------------------------------
S
-----------------------------
K
K
D
N
K
P
----------------------------
A
I
-------------------
I
F
V
D
E
I
D
A
L
L
-----V
R
---
V
---
R
N
Q
F
L
-
K
E
M
D
G
I
M
--------
M
V
Y
V
I
G
A
T
N
K
P
--
W
-----
R
----
L
D
E
P
F
L
---
R
R
F
-
Q
K
R
-
I
Y
V
P
L
P
D
F
N
Q
R
L
A
L
---
F
K
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
49.18
17%
-162
- C2 -
3EIE
2
VPS4_YEAST
A:
[51-199]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
G
I
L
L
Y
G
P
P
G
T
G
K
S
Y
----
L
A
K
A
V
A
T
E
A
N
--
S
-------
T
F
F
--
S
V
--
S
-------------------
S
S
D
--------
L
-----------
V
---------
S
-------
K
W
--
M
---
G
----
E
S
E
---
K
L
V
K
--------------
Q
L
F
A
M
A
--------------------------------------------------------------------------
R
E
N
K
P
----------------------------
S
I
-------------------
I
F
I
D
Q
V
D
A
L
T
G
T
---------EA-
S
R
R
I
K
-
T
E
L
L
V
Q
M
N
G
V
GN
D
S
Q
G
V
L
V
L
G
A
T
N
I
P
--
W
-----
Q
----
L
D
S
A
I
R
---
R
R
F
-
E
R
R
-
I
Y
I
P
L
P
D
L
A
A
R
T
T
M
---
F
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
48.97
16%
-177
- C2 -
2ZAN
2
VPS4B_MOUSE
A:
[167-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
R
G
I
L
L
F
G
P
P
G
T
G
K
S
Y
----
L
A
K
A
V
A
T
E
A
N
--
N
------
S
T
F
F
--
S
I
--
S
-------------------
S
S
-----------------------------------------------------
S
E
---
K
L
V
K
--------------
N
L
F
Q
----------
L
--
A
--------------------------------------------------------------
R
E
N
K
P
----------------------------
S
I
-------------------
I
F
I
D
E
I
D
S
L
C
G
S
R
S
E
-
N
ESE
A
---
A
R
R
I
K
-
T
E
F
L
V
Q
M
Q
G
V
GV
D
N
D
G
I
L
V
L
G
A
T
N
I
P
--
W
-----
V
----
L
D
S
A
I
R
---
R
R
F
-
E
K
R
-
I
Y
I
P
L
P
E
A
H
A
R
A
A
M
---
F
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
47.99
13%
-117
- C2 -
4KFU
6
?
A:
[2-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
P
------
D
D
I
V
V
L
V
G
R
K
K
S
G
K
S
Y
----
L
I
K
H
Y
F
I
P
V
L
--
K
A
----
H
K
I
S
Y
--
I
I
--
D
-------------------
D
H
N
-
L
-----
L
R
S
---
G
S
E
Y
S
--
K
F
--
G
---
Y
N
A
-------
T
S
--
L
---
S
----
D
I
V
S
KQ
Y
V
V
V
--------------
Y
D
R
A
K
N
D
D
F
F
E
K
L
W
Q
--
A
S
---------
K
------
L
H
S
K
K
Y
------------------------------------------
G
T
----------------------------
T
V
-------------------
L
I
I
D
E
A
Y
Y
H
F
------
K
---
Y
---
K
Q
K
V
T
-
P
A
I
D
E
A
L
H
A
N
--
R
H
A
G
L
G
L
I
L
S
T
Q
R
V
Y
D
-----------
L
M
P
I
V
Y
---
K
Q
A
-
D
L
I
-
I
M
F
Y
T
R
E
P
N
E
L
R
W
I
---
S
K
Y
I
S
A
E
A
-
A
E
-
K
V
K
T
LK
Q
Y
-
H
F
L
I
Y
D
--
V
N
-
S
Q
T
I
K
I
H
K
P
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.72
28%
-229
- C3 -
1R0X
2
CFTR_MOUSE
A:
[3-85]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
I
I
M
E
N
V
T
A
F
---
W
E
E
G
F
G
--
E
L
----
L
E
K
-------------------------
S
F
S
H
L
C
L
V
GN
P
V
-------
L
----------
K
N
I
--
N
L
N
I
E
---
K
------
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
----
L
L
M
L
I
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------