@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05620: (2016-06-09 )
MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKSIHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWTYWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWFALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVFAFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSESPFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLTQRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRKTRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIYKVRKAKHQ
Atome Classification :
(20 SA)
----------------------.........10......--..20.....-----...30........-40........50........60.-.......---70.......-.80........---90..-..-..---..100...----------..-.-.110--........120....----...-----130-.----...---------.--....----140----..---.......150.......160.......170.....-------..180.....--..-190.........200-..--.....---210-.-....----..220.......230.......--240.......-250.......260--........---------------270-.-.---....-.280------...------..--..290.......300.......310.......320.......330.......340.......350....-.-.-.360..---.....--370.----......380........390.......400..-....----.410.......420.......430----------......----...440.-----......450......--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------MTDDMTKDNI
N
Q
Q
T
L
Q
R
--
G
LKNR
H
I
Q
L
-----
I
A
IGGAI
G
T
G
L
F
L-GSG
K
S
I
H
FA
G
P
S
I
L
F
A
Y
M
I
T
G
I
I
-
C
F
L
I
M
R
S
---
L
G
E
L
L
L
SNL-
N
Y
H
S
F
V
D
F
V
Q
D
---
Y
L
G
D
-
M
A
-
A
F
---
I
T
G
W
T
Y
W
F
----------
C
W
-
I
-
S
I
A
---
M
A
D
L
T
A
V
G
L
Y
T
Q
YWL----PGV-----
P
---
Q
----
W
V
P
---------
G
--
L
I
A
L
----
I
------
I
L
---
L
I
M
N
L
A
T
V
K
L
F
G
E
L
E
F
W
F
A
L
I
K
V
I
A
I
L
A
L
I
V
I
G
L
V
-------
M
I
F
KGFSTSS--
G
V
-
S
--
S
F
T
N
L
W
SHGGLF-PN--G
M
H
G
F
---
I
L
S
-
F
-
Q
M
V
V
----
F
A
F
V
G
I
E
L
V
GLTAGETE
N
P
E
K
V
--
I
P
K
A
INNI
P
V
-
R
V
L
L
F
Y
I
G
A
L
L
V
---
I
M
SIYPWD---------------IIN-P-S---ES
P
F
-
V
Q
V
F
------
V
A
V
------
G
I
--
V
G
A
A
S
I
I
N
F
V
V
LT
S
A
A
S
A
C
N
S
A
V
F
S
T
S
R
M
V
Y
S
L
A
KDHNA
P
E
S
M
A
K
L
T
Q
RKVPR
N
A
L
F
F
S
A
I
V
I
L
I
G
V
T
L
-
N
-Y-IMP
E
G
V
---
F
T
L
I
T
--
S
I
S
T
----
V
C
F
I
Y
I
W
-
G
I
T
V
I
C
H
M
KYRKTRPELAKTNKFK-LPL
Y
----
P
F
T
N
Y
L
I
L
A
F
L
A
F
V
L
V
V
L
A
LAQ------------D
T
R
V
S
L
----
F
V
T
P
V
W
F
-----
I
L
L
I
V
I
Y
K
V
R
KAKHQ--------
11
Fugue
86.06
19%
-178
- C2 -
3GIA
7
Y609_METJA
A:
[3-435]
-----------------------------------
L
K
N
K
--
K
L
S
L
W
E
A
V
S
-----
M
A
V
G
V
M
I
G
A
S
I
F
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
---
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
---
A
I
G
D
N
I
I
-
T
G
---
A
L
S
I
L
L
W
M
----------
S
Y
-
V
-
I
S
I
---
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
NAPI
N
T
F
-----
N
---
I
----
A
I
T
---------
E
--
I
G
I
V
----
A
------
F
F
---
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
-------
T
I
H
P
S
Y
V
I
P
D
------------------
L
A
-
P
S
--
A
V
S
G
M
---
I
F
A
-
S
-
A
I
F
F
----
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
--
V
P
R
A
I
F
I
S
I
L
-
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
---------------
E
L
I
K
A
-
S
---
E
N
A
L
-
A
V
A
A
------
K
P
F
------
L
G
--
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
-
N
------------
M
E
G
V
A
--
S
I
T
S
----
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
-----
G
R
K
E
-
I
V
I
F
----
S
F
I
V
V
L
G
V
F
L
L
L
L
Y
Y
Q
W
I
T
N
R
F
------------
V
F
Y
G
I
I
----
A
T
F
I
G
V
L
-----
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
NNMYVKS-
2
PsiBlast_PDB
85.31
24%
-172
- C2 -
3GIA
6
Y609_METJA
A:
[3-362]
------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
-
G
P
---
I
A
F
I
H
K
---
A
I
G
D
----
N
I
---
I
T
G
A
L
S
I
L
----------
L
W
-
M
-
S
Y
V
---
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
-----
N
---
A
----
P
I
N
T
F
N
I
A
I
T
E
I
G
--
I
V
A
F
----
F
------
T
A
---
L
--
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
-------
T
I
H
P
S
Y
V
I
P
D
------------------
L
A
-
P
S
--
A
V
S
G
M
---
I
F
A
-
S
-
A
I
F
F
----
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
--
V
P
R
A
I
F
I
S
I
L
-
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
--------------
L
I
K
-
A
-
S
---
E
N
A
L
A
V
A
A
K
------
P
F
L
------
G
N
--
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
-
N
-
M
----
E
G
V
-------
A
--
S
I
T
S
----
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
---------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.05
24%
-170
- C2 -
3GI9
-
Y609_METJA
C:
[3-362]
------------------------------------------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
S
N
A
-
G
P
---
I
A
F
I
H
K
---
A
I
G
D
----
N
I
---
I
T
G
A
L
S
I
L
----------
L
W
-
M
-
S
Y
V
---
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
---------
A
----
P
I
N
T
F
N
I
A
I
T
E
I
G
--
I
V
A
F
----
F
------
T
A
---
L
--
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
-------
T
I
H
P
S
Y
V
I
P
D
------------------
L
A
-
P
S
--
A
V
S
G
M
---
I
F
A
-
S
-
A
I
F
F
----
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
--
V
P
R
A
I
F
I
S
I
L
-
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E
--------------
L
I
K
-
A
-
S
---
E
N
A
L
A
V
A
A
K
------
P
F
L
------
G
N
--
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
-
N
-
M
----
E
G
V
-------
A
--
S
I
T
S
----
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.88
22%
-165
- C2 -
3L1L
2
ADIC_ECO57
A:
[15-386]
-----------------------------------------------
V
T
L
-----
M
V
S
G
A
I
M
G
S
G
V
F
L
-
L
P
A
N
L
A
S
T
G
G
I
A
I
-
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
---
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
---
C
F
G
P
-
F
L
-
G
Y
---
Q
T
N
V
L
Y
W
L
A
---------
C
W
-
I
G
N
I
A
---
M
V
-
V
I
G
V
G
-
Y
L
S
Y
F
F
----
P
I
L
-----
K
---
D
P
---
W
V
L
---------
T
--
I
T
C
V
----
V
------
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
-------
W
-
F
R
G
----------
E
--
T
Y
M
A
-----------------
A
---
I
Q
S
T
L
-
N
V
T
L
----
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
--
V
P
I
A
T
I
G
G
V
L
-
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
A
---------------
A
L
R
-
V
-
S
---
A
S
P
F
-
G
D
A
A
R
-----
M
A
L
------
G
D
--
T
-
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
-
S
-
S
-
I
S
P
N
A
T
KE-
F
G
L
V
S
--
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
------------------------------------------------------------------------------------------------
23
HHSearch
79.91
15%
-171
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-402]
-------------------------------------
A
H
--
K
V
G
L
I
P
V
T
L
-----
M
V
S
G
A
I
M
G
S
G
V
F
L
-
L
P
A
N
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
---
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
---
C
F
G
P
-
F
L
-
G
Y
---
Q
T
N
V
L
Y
W
L
----------
A
C
-
W
-
I
G
N
---
I
A
M
V
V
I
G
V
G
Y
L
S
Y
F
F
----
P
I
L
K----
D
---
P
W
V
L
-
T
I
T
---------
C
--
V
V
V
L
----
W
------
I
F
---
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
-------
W
F
----
R
G
-------
E
--
T
Y
M
A
----------------
A
I
---
Q
S
T
-
L
-
N
V
T
L
----
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
--
V
P
I
A
T
I
G
G
V
L
-
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
A
---------------
A
L
R
-
V
-
S
---
A
S
P
F
-
G
D
A
A
------
R
M
A
------
L
G
--
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
-
S
-
I
S
P
N
A
T
K
E
---
F
G
L
V
S
--
S
V
S
V
----
I
F
T
L
V
P
Y
-
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
--
K
A
R
P
A
Y
---------
L
A
V
T
T
I
A
F
L
Y
C
I
W
A
V
----------------------------------------------------------------
3
PsiBlast_PDB
79.83
25%
-167
- C2 -
3GI8
-
Y609_METJA
C:
[3-362]
------------------------------------------
L
K
N
K
K
L
S
L
WEAVS
M
A
V
G
V
M
I
G
A
S
I
F
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
YTK
L
G
A
K
I
V
S
N
A
-
G
P
---
I
A
F
I
H
K
---
A
I
G
D
----
N
I
---
I
T
G
A
L
S
I
L
----------
L
W
-
M
-
S
Y
V
---
I
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
----
P
L
I
-----
N
---
A
----
P
I
N
TFNIAITEI
G
--
I
V
A
F
----
F
------
T
A
---
L
--
N
F
F
G
S
K
A
V
G
R
A
E
F
F
------
I
V
L
V
A
L
L
I
L
G
L
--------
F
I
F
A
G
L
I
T
I
H
--
P
S
-
Y
--
V
I
P
D
L
A
-------
P
S
--
A
V
S
G
M
---
I
F
A
-
S
-
A
I
F
F
----
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
--
V
P
R
A
I
F
I
S
I
L
-
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
E--------------
L
I
K
-
A
-
S
---
E
N
A
L
A
V
A
A
K
------
P
F
L
------
G
N
--
L
G
F
L
-
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
-
N
-
M
----
E
G
V
-------
A
--
S
I
T
S
----
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
---------------------------------------------------------------------------------------------------------
21
HHSearch
78.48
20%
-168
- C2 -
3GIA
6
Y609_METJA
A:
[3-370]
-----------------------------------
L
K
N
K
--
K
L
S
L
W
E
A
V
S
-----
M
A
V
G
V
M
I
G
A
S
I
F
S
-
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
---
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
---
A
I
G
D
-
N
I
I
T
G
---
A
L
S
I
L
L
W
M
----------
S
Y
-
V
-
I
S
I
---
A
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
----
N
A
P
I----
N
T
F
N
I
----
A
I
T
---------
E
--
I
G
I
V
----
A
------
F
F
---
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
I
-------
T
I
----------------
H
P
S
Y
V
I
--
P
D
L
A
-
P
S
--
A
V
S
G
M
---
I
F
A
-
S
-
A
I
F
F
----
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
--
V
P
R
A
I
F
I
S
I
L
-
I
V
M
F
V
Y
V
G
V
A
I
S
---
A
I
G
N
L
P
I
D
---------------
E
L
I
K
A
-
S
---
E
N
A
L
-
A
V
A
A
------
K
P
F
------
L
G
--
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
P
E
F
F
E
R
K
V
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
---------
F
N
---
M
E
G
V
A
--
S
I
T
S
----
A
V
F
M
V
I
Y
-
L
F
V
I
L
S
H
Y
I
L
I
D
E
V
G
-------------------------------------------------------------------------------------------------
12
Fugue
78.24
16%
-200
- C2 -
4DJK
-
GADC_ECOLI
A:
[12-501]
-------------------------
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
--
V
M
A
V
Y
E
Y
P
T
-----
F
A
T
S
G
--------------------
F
S
L
V
F
F
L
L
L
G
G
I
-
L
W
F
I
P
V
G
---
L
C
A
A
E
M
A
T
V
-
D
G
W
G
V
F
A
W
V
S
N
---
T
L
G
P
-
R
W
-
G
F
---
A
A
I
S
F
G
Y
L
----------
Q
I
-
A
-
I
G
F
---
I
P
M
L
Y
F
V
L
G
A
L
S
Y
-
I
----
L
K
W
-----
P
---
A
----
L
N
E
---------
D
P
I
T
K
T
I
----
A
------
A
L
---
I
I
L
W
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
-------
L
I
A
L
A
A
I
Y
L
H
--
T
--------------
F
F
P
-
D
F
--
S
K
V
G
T
---
L
V
V
-
F
-
V
A
F
I
----
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
--
Y
P
L
A
M
L
L
L
M
V
-
A
A
I
C
L
S
S
V
G
G
L
S
---
I
A
M
V
I
P
G
N
---------------
E
I
N
-
L
-
S
----
A
G
V
-
M
Q
T
F
------
T
V
L
M
SHVAP
E
I
--
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
-
L
-
T
-
N
T
G
G
G
N
N
M
S
F
L
I
A
L
--
A
L
T
V
----
V
I
Y
L
C
A
Y
-
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
L
K
R
--
T
F
N
-
I
P
G
G
----
K
-
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
LPPDNIQGDS
T
D
M
Y
V
E
----
L
L
V
V
S
F
L
-----
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
LHPRARSP
7
PsiBlast_PDB
77.77
21%
-154
- C2 -
3LRC
-
ADIC_ECO57
A:
[15-386]
-----------------------------------------------
V
T
L
-----
M
V
S
G
N
I
M
G
S
G
V
F
L
-
L
P
A
N
L
A
S
T
G
G
I
A
I
-
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
---
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
---
C
F
G
P
-
F
L
-
G
Y
---
Q
T
N
V
L
Y
W
L
A
---------
C
W
-
I
G
N
I
A
---
M
V
-
V
I
G
V
G
-
Y
L
S
Y
F
F
----
P
I
L
-----
K
---
D
PL
V
L
T
I
T
---------
C
--
V
V
V
L
----
W
------
I
F
---
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
-------
W
-
F
R
G
----------
E
--
T
Y
M
A
A
W
N
V
S
G
L
------
G
T
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
----
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
--
V
P
I
A
T
I
G
G
V
L
-
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
------------------------------------------------------
T
-
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
-
S
-
S
-
I
S
P
N
A
T
KE-
F
G
L
V
S
--
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.22
21%
-153
- C2 -
3LRB
-
ADIC_ECO57
A:
[15-386]
-----------------------------------------------
V
T
L
-----
M
V
S
G
N
I
M
G
S
G
V
F
L
-
L
P
A
N
L
A
S
T
G
G
I
A
I
-
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
---
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
---
C
F
G
P
-
F
L
-
G
Y
---
Q
T
N
V
L
Y
W
L
A
---------
C
W
-
I
G
N
I
A
---
M
V
-
V
I
G
V
G
-
Y
L
S
Y
F
F
----
P
I
L
-----
K
---
D
PL
V
L
T
I
T
---------
C
--
V
V
V
L
----
W
------
I
F
---
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
-------
W
-
F
R
G
----------
E
--
T
Y
M
A
A
W
N
V
S
G
L
------
G
T
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
----
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
--
V
P
I
A
T
I
G
G
V
L
-
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
------------------------------------------------------
T
-
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
-
S
-
S
-
I
S
P
N
A
T
KE-
F
G
L
V
S
--
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.17
22%
-186
- C2 -
3OB6
1
ADIC_ECOLI
A:
[76-386]
------------------------------------------------------------------------------------------------------------------------
Y
A
R
R
---
C
F
G
P
-
F
L
-
G
Y
---
Q
T
N
V
L
Y
W
L
A
---------
C
W
-
I
-
G
A
I
---
A
M
V
V
I
G
V
G
-
Y
L
S
Y
F
F
----
P
I
L
-----
K
---
D
P
L
V
L
T
I
T
---------
C
--
V
V
V
L
----
W
------
I
F
---
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
F
-------
W
-
F
R
G
----------
E
--
T
Y
M
A
A
W
N
V
S
G
L
------
G
T
F
G
A
---
I
Q
S
T
L
-
N
V
T
L
----
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
--
V
P
I
A
T
I
G
G
V
L
-
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
A
---------------
A
L
R
-
V
-
S
---
A
S
P
F
-
G
D
A
A
R
-----
M
A
L
------
G
D
--
T
-
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
-
F
Q
L
-
S
-
S
-
I
S
P
-------
G
L
V
S
--
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
A
------------------------------------------------------------------------------------------------
22
HHSearch
71.56
15%
-202
- C2 -
4DJK
-
GADC_ECOLI
A:
[12-457]
-----------------------------------------
Q
L
T
L
L
G
F
F
A
-----
I
T
A
S
M
V
M
--
A
V
Y
E
-
Y
P
--
T
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
---
A
A
E
M
A
T
V
D
G
W---
G
V
F
A
W
V
S
N
---
T
L
G
P
-
R
W
-
G
F
---
A
A
I
S
F
G
Y
L
----------
Q
I
-
A
-
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
Y
I
L
K
W
-----
P
A
L
NEDP
I
T
---
K
----
T
I
A
---------
A
--
L
I
I
L
----
W
------
A
L
---
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
L
L
P
A
F
I
L
I
A
L
A
A
-------
I
Y
L
H
----------------------
T
F
F
P
-
D
F
--
S
K
V
G
T
---
L
V
V
-
F
-
V
A
F
I
----
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
--
Y
P
L
A
M
L
L
L
M
V
-
A
A
I
C
L
S
S
V
G
G
L
S
---
I
A
M
V
I
P
G
N
---------------
E
I
N
-
L
-
S
A
G
V
M
Q
T
F
-
T
V
L
M
------
S
H
V
------
A
P
EI
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
-
L
T
N
-
T
G
G
G
N
N
---
M
S
F
L
I
A
L
A
L
T
V
----
V
I
Y
L
C
A
Y
-
F
M
L
F
I
G
Y
I
V
L
V
L
K
H
P
D
--
L
K
R
T
F
N
-
I
P
G
G
K
G
V
K
L
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
F
L
P
----------------------------------------------------------
8
PsiBlast_PDB
68.08
21%
-184
- C2 -
3NCY
-
ADIC_SALTY
A:
[76-402]
------------------------------------------------------------------------------------------------------------------------
Y
A
R
R
---
C
F
G
P
-
F
L
-
G
Y
---
Q
T
N
V
L
Y
W
L
A
---------
C
W
-
I
G
N
I
A
---
M
V
-
V
I
G
V
G
-
Y
L
S
Y
F
F
----
P
I
L
-----
K
---
D
------
P
---------
L
--
V
L
T
L
----
T
C
V
A
V
L
W
I
F
---
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
V
P
I
V
G
I
A
V
F
G
W
F
-------
W
-
F
K
G
----------
E
-------
W
N
V
S
G
M
---
N
--
T
F
G
A
I
---
Q
S
T
-
L
-
N
V
T
L
----
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
--
V
P
I
A
T
I
G
G
V
L
-
I
A
A
V
C
Y
V
L
S
T
T
A
---
I
M
G
M
I
P
N
A
---------------
A
L
R
-
V
-
S
---
A
S
P
F
-
G
D
A
A
R-----
M
A
L
------
G
D
--
T
-
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
P
P
I
F
A
R
-----
T
P
V
A
G
L
L
I
V
G
V
L
M
T
I
-
F
Q
F
-
S
-
S
-
M
S
P
N
A
A
K
E
-
F
G
L
V
S
--
S
V
S
V
I
F
T
L
V
P
Y
L
Y
T
C
A
A
L
L
L
L
G
H
G
H
F
G
K
A
R
P
L
---------------------
Y
L
L
I
T
F
V
A
F
V
Y
C
I
W
A
V
-----------------------------------------------------------
19
Fugue
60.44
16%
-156
- C2 -
5DFM
10
MALE_ECOLI
A:
[1-527]
KIEEG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
-----
A
A
----------
T
-
G
D
G
P
D
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
------------
L
A
E
I
T
P
D
K
A
-
F
Q
D
K
L
Y
P
F
T
W
D
A
V
R
Y
N
G
K
-
L
I
-
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
KDLLPNPPK
T
W
-
E
-
E
I
P
---
A
L
D
K
E
L
K
S
A
L
--
M
F
N
----
L
Q
E
-----
P
---
Y
----
F
T
W
---------
P
--
L
I
A
A
D
G
G
Y
A
------
F
K
---
Y
E
N
G
K
Y
D
I
K
D
V
G
-
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
NADTD
Y
S
I
A
E
A
A
F
N
K
G
E
--
T
A
-
M
--
T
I
N
G
P
W
A
W
S
N
I
D
-
T
S
--
K
V
N
Y
G
---
V
T
V
-
L
-
P
T
F
K
GQPS
K
P
F
V
G
V
L
S
A
G
I
N
A
-
A
S
P
N
K
E
L
A
--
K
E
F
L
E
N
Y
L
L
T
-
D
E
G
L
E
A
V
N
K
D
K
P
---
L
G
A
V
A
L
K
S
---------------
Y
E
E
-
E
L
A
---
K
D
P
R
-
I
A
A
T
------
M
E
N
------
A
Q
--
K
G
E
I
-
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
T
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
M
Q
Q
P
K
R
N
F
D
L
Y
K
L
I
T
D
K
Q
I
D
F
Q
V
A
D
-
L
-
I
Q
D
E
Q
S
---
S
F
V
S
V
--
R
I
Y
G
----
Q
F
K
C
F
V
P
-
K
S
T
I
Q
E
Q
L
D
K
I
K
N
L
K
E
L
A
K
N
K
I
F
K
F
L
S
E
Y
----
N
Y
Y
G
Y
F
K
V
Q
Q
H
Q
F
I
L
N
L
E
N
A
Q
R
------------
E
A
S
L
A
V
D
D
F
Y
F
I
N
G
R
I
Y
K
T
N
HD
I
L
I
L
Q
A
H
H
V
Y
Q
M
Q
K
P
TLQLLQA-
18
Fugue
56.59
14%
-144
- C2 -
4KPP
4
?
A:
[2-396]
-------------------------
D
F
T
K
E
K
F
Q
L
L
A
I
S
S
--
L
T
L
P
W
L
I
S
L
-----
A
F
N
Y
H
H
P
A
L
T
Q
T
L
-
L
S
G
L
A
V
V
S
A
S
F
L
I
S
W
A
A
E
T
A
E
M
D
----
V
P
R
S
---
F
S
L
A
I
V
A
L
L
-
A
V
L
P
E
Y
A
-
V
D
G
---
Y
F
A
W
-
K
A
-
G
S
---
V
G
G
E
Y
V
H
Y
----------
A
T
-
A
-
N
M
T
---
G
A
N
R
L
L
I
G
I
----------------------------
G
W
---------
S
--
L
V
A
F
----
I
------
A
F
---
R
T
L
K
S
K
E
V
E
L
D
D
G
I
R
L
E
I
F
F
L
F
L
A
T
L
Y
A
-------------------------------------------
F
-
T
L
--
P
L
K
G
H
---
I
S
P
-
F
-
D
A
L
V
----
F
V
S
L
Y
A
I
Y
I
Y
L
S
T
K
A
E
R
E
E
V
E
V
G
G
V
P
A
Y
L
C
S
L
K
T
-
E
T
R
R
L
S
V
V
V
L
F
L
---
F
A
G
F
T
I
L
M
---------------
S
V
E
-
A
-
F
---
S
E
G
L
-
L
E
T
A
------
R
I
A
------
G
I
--
D
E
F
L
A
V
Q
W
I
A
P
L
A
S
E
S
P
E
L
I
V
A
I
Y
F
V
R
R
--------
F
R
V
S
A
S
M
N
A
L
I
S
S
K
V
N
Q
W
T
L
L
I
G
T
I
A
I
I
Y
S
I
S
A
-
F
-
K
-
L
Q
S
L
P
L
D
--
A
R
Q
S
E
--
E
V
L
L
----
T
A
A
Q
S
L
F
-
A
V
A
I
L
L
D
L
K
I
S
W
K
E
A
S
A
L
F
L
L
F
I
V
-
Q
L
L
F
----
P
G
V
E
V
R
Y
I
I
S
A
I
Y
I
I
L
S
L
P
I
L
F
------------
A
K
R
K
E
I
----
V
E
S
F
R
T
V
-----
K
R
L
I
S
L
E
----------------
9
PsiBlast_PDB
43.09
25%
-172
- C2 -
4DJI
-
GADC_ECOLI
A:
[202-342]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
---
L
V
V
-
F
-
V
A
F
I
----
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
--
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
---
A
M
V
I
-
P
G
N
---------------
E
I
N
-
L
-
S
---
A
G
-
V
-
M
Q
T
F
T
V
L
M
S
H
V
A
P
------
E
I
--
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.97
25%
-179
- C2 -
4DJK
-
GADC_ECOLI
A:
[202-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
---
L
V
V
-
F
-
V
A
F
I
----
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
--
Y
P
L
A
M
L
L
L
M
V
A
A
I
C
L
S
S
V
G
G
L
S
I
---
A
M
V
I
-
P
G
N
---------------
E
I
N
-
L
-
S
---
A
G
-
V
-
M
Q
T
F
T
V
L
M
SH
V
A
P
------
E
I
--
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
P
A
A
F
A
K
M
N
K
N
G
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
40.91
12%
-129
- C2 -
3DH4
3
?
A:
[50-349]
----------------------------------
N
K
A
G
K
--
S
L
P
W
W
A
V
G
A
-----
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
-
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
-
L
I
I
V
G
K
Y
---
F
L
P
I
F
I
E
K
--
G
I
Y
T
I
P
E
F
V
E
K
---
R
F
N
K
-
K
L
-
K
T
---
I
L
A
V
F
W
I
S
----------
L
Y
I
F
-
V
N
L
---
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
----
G
-
I
-----
P
---
L
----
M
Y
S
I--------
L
--
G
L
A
L
----
F
------
A
L
---
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
-------
F
I
G
G
T
D
G
W
F
A
GV
S
K
M
V
DA
A
P
G
H
F
E
M
I
L
D
Q
S
N
P
Q
YM
N
L
P
G
I
AVL
I
G
G
-
L
W
V
A
N
L
----
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
-
S
E
--
A
Q
K
G
I
V
F
A
A
F
-
L
K
L
I
V
P
F
L
V
V
L
P
GIA
A
Y
V
I
T
S
D
P
QLMASLGDIAATNLP
S
A
A
-
N
-
A
---
D
K
A
Y
-
P
W
L
T
-------
Q
F
------
L
P
--
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
38.41
22%
-128
- C1 -
1AFO
-
GLPA_HUMAN
A:
[92-100]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
G
I
R
R
L
I
K
---------
14
Fugue
30.38
16%
-107
- C2 -
3F5H
-
?
A:
[12-65]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
D
D
L
D
A
E
A
L
I
R
M
A
L
G
P
R
N
T
M
T
S
S
N
E
Q
L
V
D
A
L
R
A
S
L
K
E
N
E
E
L
R
K
E
S
R
R
R
A
D
R
R
Q
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