@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05650: (2016-06-09 )
MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPADAVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPLSAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQDFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVYNVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTLFISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPSKKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYKSIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTITQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNGGSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQANQQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTGIFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEVDGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYMIASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEEVHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGLVILPLFIPAIIATFGEGNWWPFGRKKGKE
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------.........10...-------..-----...20........30.....---...40........50........60........70---........80........90........100.......110.........120.......130.......140..---------------------------.....150----.......----.160......--------.170....-----.-------------..180..--.....190....-----...200.......-210.--.....------------.220.......230.......240---.......250....-.-..260.......270.......280.......290--..---.---...--...300.-......310.....--..320.......330----......-.----.----340-----.-------....-....350.......360-----.......370..-......380...---------...-----.390.......400.---------------..-------.-.-..410..--.....420..--.....430.......440-..--...-----------...450.......460-----.......470......------.480..--.....490-.......500.-.---.-.------..----..510-....--------.-..520........530.......540....----..----------------.550......--.560......-.570..-.--------------.-----.-------..----..580.......590.......600-.-----.....----------.----------.610.......620-........630......---.640........650.......660.......670.......680.......--690....-...700..-----------.....710......--.---720.-......730.......--740.......750.-.....--.--760..----..--...770....---....780........790........800-.--.---...-....810........820.......830.--.---.---..---..840--.......850.---......860.......870.......880...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------MR
A
I
I
K
F
K
W
A
I
A
A
I
-------
V
L
-----
A
L
T
V
V
L
S
L
FSP
N
L
T
E
L
ANQK---GQAQL
P
A
D
A
V
S
E
R
A
N
A
I
L
K
QAGEDNN
S
I
S
V
V
F
TLD---
N
A
I
K
KETE
N
Q
L
R
I
I
I
D
K
I
K
KID
G
V
E
E
V
TSPL
S
A
E
K
E
V
K
D
--
Q
L
MSKDK
K
T
V
L
M
P
V
T
ITGS
D
K
K
A
E
K
I
A
D
E
I
Y
Q
IV---------------------------
P
D
D
L
T
A
Y
-----
I
T
G
A
S
L
I
----
N
Q
D
FAHSSEE--------GLKKT
E
V
I
-----
T
-------------
V
C
L
I
I
G
L
--
L
L
I
V
F
R
S
V
V
T
P
F
-----
I
P
I
V
V
V
G
F
S
Y
L
I
S
-
Q
S
I
L
--
G
I
L
V
Y
------------NVDFP
I
S
T
F
T
Q
T
F
L
V
A
I
L
F
GI
G
T
D
---
Y
C
I
L
L
L
T
R
F
R
E
E
L
A-N-GHDKK
E
A
A
L
I
A
Y
RTGG
K
T
L
F
I
S
G
F
A
V
L
I
G
F
S
A
L
----
G
F
---
A
---
K
F
A
--
I
F
Q
S
A
V
G
-
V
A
V
G
V
G
I
L
M
I
I
L
Y
T
--
L
L
P
L
F
M
V
T
L
G
E
K
LF-----WP
S
K
K
V
-L----S----H-------S-------DN
K
L
-
W
A
F
LGRHSVA
R
P
F
L
F
I
V
-----
I
T
V
V
I
TL
P
-
F
I
L
-TYDDQISFDS
T
A
---------
E
I
S
-----
S
D
Y
K
S
I
K
A
L
E
A
I
K
DG---------------FG-------E-G-
K
A
F
P
I
N
V
--
V
V
KGDKDLTT--ADTIPYL
G
N
I
S
K
A
I
E
K
V
--
D
H--VDS-----------
V
M
T
ITQPTGK
K
I
K
D
L
Y
-----IDNQLGSVSD
G
L
D
K
T
V
------
K
G
I
A
D
V
--
Q
S
G
L
T
D
I
E
-
N
G
L
N
Q
M
AG-QT-G---S-A------SN----GGSGG-SLG
D
--------
A
-
A
D
G
-
L
G
K
I
N
Q
Q
L
Q
L
V
S
K
Q
I
S
QTG
N
T
A
Q
T
V
Q
----
Q
L
----------------
T
A
I
SGQ
L
G
Q
I
--
Q
T
G
L
E
Q
A
N
Q
Q
-LS--GQ-Q--------------A-----Q-------A
G
----
T
L
T
E
S
L
K
K
L
S
E
G
V
K
S
A
NEG
L
T
K
VS--D-----GIT
A
S
----------
S
----------
D
I
L
E
D
MSKSPTV-R-DTGIFI
P
D
Q
V
MK
D
K
D
F
K
---
K
S
-
I
D
QYSFADGK
G
V
Q
L
S
V
V
LDSNPYS
E
Q
A
I
T
T
I
N
Q
I
K
K
A
V
ANEVDGTPLEN--
A
Q
I
V
Y
GG-VTSMN
A
D
L
-----------
K
E
LSTTDFS
R
T
M
V
I
--
M
---
I
I
G
L
-
F
I
V
L
T
I
L
F
R
S
M
I
M
P
I
Y
--
M
I
A
S
L
L
L
T
Y
YTSI
S
-
I
T
E
L
I
--
F
--VNGLG----NA--G
V
S
W
-
A
V
P
F
F
---
S
F
V
I
L
I
-ALGVD
Y
S
I
F
-
L
L
D
R
F
K
E
E
V
H
---
L
--
G
---
I
E
Q
-
G
V
V
R
S
M
-
S
K
M
G
S
V
I
I
T
A
A
I
I
L
A
G
T
F
A
A
MM--P---
S
---
G
V
---
N
T
L
M
Q
--
V
A
S
V
I
I
I
G
L
L
L
---
Y
G
L
V
I
L
P
L
F
I
P
A
I
I
A
TFGEG
N
W
WPFGRKKGKE
38
Fugue
75.37
17%
-107
- C2 -
4MT1
-
?
A:
[2-1040]
--------------------------------------------------------------------------------------------------------------------------------------------A
K
F
F
I
D
R
P
I
F
A
W
V
I
S
I
F
I
I
A
A
G
I
F
G
I
K
S
L
PVSQYPS
V
A
-----
A
P
T
I
T
L
H
A
I
Y
P
G
A
S
A
Q
V
M
E
G
SV
L
S
V
I
E
R
N
M
N
G
V
E
G
L
D
Y
M
S
T
S
A
D
S
S
G
S
G
S
V
S
L
T
F
T
P
D
TD
E
N
L
A
Q
V
E
V
Q
N
K
L
S
-------------
E
V
L
S
T
L
P
A
T
V
Q
Q
Y
G
--
V
T
V
S
K
A
R
S
N
F
L
M
I
V
M
L
S
S
D
V
Q
S
T
E
E
M
N
D
Y
A
Q
R
N
V
VPELQRIEGVG
Q
V
R
L
FGAQRAM
R
I
W
V
D
P
K
K
L
Q
N
Y
NLS
F
A
D
V
G
S
A
L
S
----
A
Q
N
I
Q
I
S
A
G
S
I
GSLPAVR
G
Q
T
V
T
A
T
V
-----
T
A
Q
GQLGT
A
E
E
F
G
N
V
I
L
R
A
N
T
DG
S
N
I
Y
L
K
D
V
A
K
V
G
-----
L
G
M
E
D
Y
S
S
S
T
R
L
N
G
V
N
T
T
--
G
M
A
V
M
L
S
NSGNA
M
A
T
A
K
A
V
K
E
R
L
A
V
L
E
K
Y
F
P
Q
G
M
S
W
K
T
P
Y
D
T
S
K
F
V
E
I
S
I
E
K
V
I
H
T
L
I
-
E
-
A
M
V
L
V
F
V
V
M
Y
L
F
L
Q
N
I
R
Y
T
L
I
P
T
I
V
V
P
I
S
L
L
G
-----
G
F
---
A
---
F
I
S
--
Y
M
G
M
S
I
N
-
V
L
T
M
F
A
M
I
L
V
I
G
I
V
--
V
D
D
A
I
V
V
V
E
N
V
E
R
I
M
A
G
EG
L
P
P
K
E
A
-
T
----
K
----
K
-------
A
-------
M
G
Q
I
S
G
A
V
I
G
I
T
A
V
L
I
S
V
F
V
P
L
AMFSG
A
A
G
N
I
Y
K
Q
-
F
A
L
-
T
M
A
S
S
I
A
F
S
A
F
L
---------
A
L
T
LT
P
A
L
C
A
T
G
F
F
G
W
F
N
K
K
F
D
S
---------------
W
T
-------
H
-
G
-
Y
E
G
R
V
A
K
--
V
L
R
K
----
T
F
--
R
M
M
V
V
Y
I
G
L
A
V
V
G
V
F
L
F
--
M
R
--
L
P
T
S
F
L
PTEDQG
F
V
M
V
S
V
Q
L
P
A
G
--
A
T
K
E
R
-----
T
D
A
T
L
A
Q
V
T
Q
L
A
-
K
S
I
------
P
E
I
E
N
I
I
T
V
S
G
F
S
F
S
G
-
S
G
Q
N
M
A
M
G
-
F
A
-
I
---
F
-
K
------
D
W
----
N
E
R
T
A
-
S
G
S
D
--------
A
-
V
A
V
-
A
G
K
L
T
G
M
M
M
G
T
L
K
D
G
F
G
I
A
V
V
P
P
P
I
L
----
E
L
G
S
G
L
S
I
N
L
Q
D
RNNTG
H
T
A
L
L
A
K
R
N
E
L
--
I
Q
K
M
R
A
S
G
L
F
-
D
P
--
S
T
-
V
--------------
R
-----
A
-------
G
G
----
L
E
D
S
P
Q
L
K
I
D
I
N
R
A
A
A
A
A
Q
G
I
S
F
A
--
D
-----
I
R
T
A
L
----------
A
----------
S
A
L
S
S
-
S
Y
V
S
D
F
-
P
-
N
Q
G
R
L
Q
R
V
M
V
Q
A
D
E
D
A
R
MQP
A
D
-
I
L
N
L
T
V
P
N
K
S
G
V
A
V
P
L
S
T
I
A
T
V
S
W
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N
G
T
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Q
S
V
R
F
N
G
Y
P
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M
K
L
S
A
S
P
A
T
G
VS
T
G
Q
A
M
E
A
-
V
Q
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M
V
D
E
L
GGG
Y
S
F
E
W
G
G
Q
S
S
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A
K
G
G
S
Q
T
L
I
L
--
Y
G
L
A
V
A
A
V
-
F
L
V
L
A
A
L
Y
E
S
W
S
I
P
L
A
--
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
T
G
R
N
--
L
--
F
E
G
L
L
----
G
S
--
V
P
S
F
-
A
N
D
I
Y
F
Q
V
G
F
V
T
V
M
-
G
L
S
A
K
N
A
I
L
-
I
I
E
F
A
K
D
L
Q
A
---
Q
--
G
KS
A
V
E
A
-
A
L
E
A
A
R
-
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
L
Y
I
--
A
---
A
---
G
A
---
S
S
A
S
Q
--
R
A
I
G
T
T
V
F
W
G
M
---
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
----------
25
HHSearch
70.46
14%
-144
- C2 -
4MT1
-
?
A:
[317-1040]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
M
S
W
K
-----
T
P
Y
---
D
----
T
S
K
F
V
E
I
S
I
E
--------
K
V
I
H
T
L
I
E
-----
A
-------------
M
V
L
V
F
V
V
--
M
Y
L
F
L
Q
N
I
R
Y
T
L
-----
I
P
T
I
V
V
P
I
S
L
L
G
G
-
F
A
F
I
--
S
Y
M
G
M
------------
S
----
I
N
V
L
T
-
M
F
A
M
I
L
V
I
G
I
V
V
D
---
D
A
I
V
V
V
E
N
V
E
R
I
M
A
G
E
-
G
L
P
P
K
E
A
T
K
K
A
M
G
Q
I
S
G
A
V
I
G
I
T
A
V
L
I
S
V
F
V
P
L
----
A
M
---
F
SG
A
A
G
N
--
I
Y
K
Q
F
A
L
T
M
A
S
S
I
A
F
S
A
F
L
A
L
T
--
L
T
P
A
L
C
A
T
-----------------G
F
F
G
W
F
N
K
K
F
-
D
-------
S
-------
W
T
H
G
-
Y
E
G
R
V
A
K
V
L
R
K
T
F
R
M
M
V
-----
V
Y
I
G
L
A
V
V
G
V
F
L
-
F
M
R
L
P
T
-----
S
---------
F
L
P
-----
T
E
D
-----------------------------------------
Q
G
F
V
M
V
--
S
V
Q
L
P
A
G
A
T
K
--
E
R
T
D
A
T
L
A
Q
V
T
Q
L
A
K
S
I
--
P
E
--
I
E
N
-----------
I
I
T
V
S
G
F
S
F
S
G
S
----------
G
Q
N
M
A
M
G
F
A
I
F
K
D
W
N
ERTASG
S
D
A
V
A
V
--
A
G
K
L
T
G
M
M
M
G
T
L
K
D
G
F
G
I
A
V
-
V
P
P
P
I
-
L
------
E
L
G----
S
G
L
S
I
N
L
Q
D
--------
R
N
N
T
G
-
H
T
A
L
L
A
K
R
N
E
L
I
Q
K
M
R
A
S
G
L
--------------------------------
F
D
P
S
T
V
--
R
A
G
G
-------
L
E
--
D
S
P
Q
--------------
L
-----
K
I
D
I
N
R
A
A
A
A
----
A
Q
G
I
S
F
A
D
I
R
T
A
L
A
S
A
L
S
S
S
Y
V
S
D
F
P
N
-----
Q
G
R
L
Q
----------
R
V
M
V
Q
A
D
EDAR
M
Q
P
A
D
I
L
N
L
T
V
P
-
N
-
K
S
G
V
A
V
P
L
S
T
I
A
T
V
S
W
E
---
N
G
-
T
E
Q
S
V
R
F
N
G
Y
P
S
-
M
K
L
S
A
S
P
A
T
G
-
V
S
T
G
Q
A
M
E
A
V
Q
K
M
V
D
E
-----
L
G
G
G
--
Y
S
F
E
W
G
G
-
Q
S
S
E
E
A
K
---------------
G
G
S
Q
T
L
I
L
Y
G
L
--
A
---
V
A
A
V
-
F
L
V
L
A
A
L
Y
E
S
W
S
I
P
L
A
--
V
I
L
V
I
P
L
G
L
I
G
A
A
A
-
G
V
T
G
R
--
N
L
F
E
G
L
L
G
SVPS
F
A
---
N
D
I
--
Y
F
Q
V
---
G
F
V
T
V
M
-
G
L
S
A
K
N
A
I
L
-
I
I
E
F
A
K
D
L
Q
A
---
Q
--
G
K--
S
A
V
E
A
A
L
E
A
A
-
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
L
Y
--
I
---
A
AGA
S
S
---
A
S
Q
R
A
--
I
G
T
T
V
F
W
G
M
L
V
---
G
T
L
L
-
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
-----------
24
HHSearch
68.50
14%
-139
- C2 -
3W9I
3
MEXB_PSEAE
A:
[318-1030]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
G
M
K
V
V
-----
Y
P
Y
D
T
T
-------
P
V
V
S
A
S
I
H
--------
E
V
V
K
T
L
G
E
-----
A
-------------
I
L
L
V
F
L
V
--
M
Y
L
F
L
Q
N
F
R
A
T
L
-----
I
P
T
I
A
V
P
V
V
L
L
G
T
-
F
G
V
L
--
A
A
F
G
F
------------
S
----
I
N
T
L
T
-
M
F
G
M
V
L
A
I
G
L
L
V
D
---
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
-
G
L
S
P
R
E
A
A
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
L
P
M
----
A
F
FGG
S
---
T
G
V
--
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
--
L
T
P
A
L
C
A
T
M
L
K
P
--------------------F
F
--
G
W
F
N
R
M
F
L
S
-------
T
T
H
G
-
Y
E
R
G
V
A
S
I
L
K
H
R
A
P
Y
L
L
-----
I
Y
V
V
I
V
A
G
M
I
W
M
-
F
T
R
I
P
T
-----
A
---------
F
L
P
-----
D
E
D
---
Q
G
V
L
F
A
Q
V
Q
---------------
T
P
-------
P
-
G
-----------------
S
S
A
--
E
R
T
Q
V
V
V
D
S
M
R
E
Y
L
L
E
K
ES
S
S
--
V
S
S
-----------
V
F
T
V
T
G
F
N
F
A
G
----------
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
W
E
ERPGGE
N
S
V
F
E
L
--
A
K
R
A
Q
M
H
F
-
F
S
F
K
D
A
M
V
-
F
A
F
A
---
P
-
P
SVLEL-
G
N
----
A
T
G
F
D
L
F
L
Q
D
Q-------
A
-
G
V
G
-
H
E
V
L
L
Q
A
R
N
K
F
L
M
L
A
A
Q
N
P
----------------------------------
A
L
Q
R
V
--
R
P
N
G
M
------
S
D
--
E
P
-
Q
--------------
Y
-----
K
L
E
I
D
D
E
K
A
S
----
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
-----
R
G
R
V
K
----------
R
V
Y
L
Q
G
R
PDAR
M
N
P
D
D
L
S
K
W
Y
V
R
-
N
-
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
---
Y
G
-
S
P
K
L
E
R
Y
N
G
V
P
A
-
M
E
I
L
G
E
P
A
P
G
-
L
S
S
G
D
A
M
A
A
V
E
E
I
V
K
-----
Q
L
P
K
G
--
V
G
Y
S
W
T
G
-
L
S
Y
E
E
---------------
R
L
S
G
-
Q
A
P
A
L
Y
A
L
--
S
---
L
L
V
V
-
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
--
V
M
L
V
V
P
L
G
V
I
G
A
L
L
-
A
T
S
M
---------
R
G
----
L
S
---
N
D
V
--
F
F
Q
V
---
G
L
L
T
T
I
-
G
L
S
A
K
N
A
I
L
-
I
V
E
F
A
K
E
L
H
E
---
Q
--
G
K--
G
I
V
E
A
A
I
E
A
C
-
R
M
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
L
A
--
I
---
S
---
T
G
A
G
S
G
S
Q
H
A
--
I
G
T
G
V
I
G
G
M
V
T
---
A
T
V
L
-
A
I
F
W
V
P
L
F
Y
V
A
V
S
T
L
------------
23
HHSearch
67.45
12%
-147
- C2 -
4K0J
1
?
A:
[313-1018]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
V
K
V
V
-----
P
Y
I
D
R
-------
S
N
L
V
D
A
T
V
H
--------
T
V
G
K
T
L
M
E
-----
G
-------------
M
F
L
V
S
L
V
--
L
L
L
F
L
G
S
P
R
A
A
I
-----
I
V
A
V
T
I
P
L
S
L
L
M
A
-
F
I
L
M
--
H
H
F
K
I
------------
P
----
A
N
L
L
S
-
L
--
G
A
I
D
F
G
I
I
V
D
---
G
A
I
V
V
M
E
N
I
L
R
R
R
----------
D
I
M
Q
S
V
L
Q
V
A
R
P
I
F
F
G
M
I
V
I
I
T
A
Y
L
P
L
----
F
A
FQR
I
---
E
Y
K
--
L
F
S
P
M
A
F
A
V
G
F
A
L
F
G
A
L
L
V
A
L
L
--
L
I
P
G
L
A
--------------------
A
----
L
----
V
-------
W
-------
L
A
P
R
-
Y
E
S
V
L
N
R
---
S
T
R
T
A
I
G
-----
I
A
V
A
T
L
V
G
V
M
I
L
-
G
A
T
I
-----
G
R
D
---------
F
L
P
-----
Y
L
D
E
-----------------------------------------
G
S
I
W
L
--
Q
V
T
L
P
P
G
I
S
L
--
E
K
A
G
Q
M
A
D
N
L
R
A
A
T
M
E
F
--
P
E
--
V
E
H
-----------
V
V
T
Q
V
G
R
N
D
E
G
T
D
--
P
-----
F
S
P
S
H
I
E
T
A
V
T
L
H
P
Y
S
TWTSG-
R
D
K
Q
Q
L
--
I
E
A
M
A
T
R
F
-
R
D
L
P
G
T
Q
V
-
G
F
-
S
---
Q
-
P
M
I
D
G
V
L
D
K
L
AGA
H
S
D
L
V
V
K
V
Y
-----------
G
N
D
-
F
A
E
T
R
Q
V
A
T
A
I
T
R
L
L
K
T
V
P
G
----------------------------------
A
Q
D
V
--
I
I
D
Q
-------
E
P
--
P
L
P
Q
--------------
V
-----
R
I
D
V
D
R
A
A
A
A
----
R
L
G
I
N
V
A
D
V
M
A
L
I
Q
T
G
I
G
G
S
P
V
T
Q
V
F
V
-----
E
D
R
S
Y
----------
N
V
V
A
R
F
I
GSSR
N
D
P
E
A
I
G
N
L
T
L
T
-
A
-
A
N
G
A
H
V
A
L
A
Q
V
A
H
I
R
L
A
---
E
G
-
E
T
T
I
T
R
E
M
N
K
R
H
-
L
T
V
R
L
N
L
R
--
G
R
D
L
S
T
F
L
E
E
A
R
M
R
I
D
K
E
V
P
-
Y
D
R
T
H
--
I
Q
V
A
W
G
G
-
Q
F
E
N
---------------
Q
Q
R
A
Q
A
R
L
A
V
I
L
P
M
--
V
---
L
A
L
M
-
F
V
L
L
F
-------
Q
P
A
L
--
I
L
M
A
V
P
L
A
T
L
G
G
L
V
-
A
L
H
L
---------
R
G
----
M
T
---
L
N
V
--
S
S
A
V
---
G
F
I
A
L
F
-
G
V
A
V
L
N
A
I
I
-
M
I
A
N
L
-----------------
K
E
A
V
V
R
G
A
-
G
E
R
M
R
P
V
L
M
T
A
T
V
A
A
L
G
L
I
P
A
A
--
L
---
A
HGL
G
S
---
D
V
Q
R
P
--
L
A
T
V
V
V
G
G
L
I
T
---
A
T
A
L
-
T
L
V
L
L
P
A
L
Y
Y
L
I
E
T
R
------------
26
HHSearch
65.40
13%
-148
- C2 -
4DX5
9
ACRB_ECOLI
A:
[318-1038]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
G
L
K
I
V
-----
Y
P
Y
D
T
T
-------
P
F
V
K
I
S
I
H
--------
E
V
V
K
T
L
V
E
-----
A
-------------
I
I
L
V
F
L
V
--
M
Y
L
F
L
Q
N
F
R
A
T
L
-----
I
P
T
I
A
V
P
V
V
L
L
G
T
-
F
A
V
L
--
A
A
F
G
F
------------
S
----
I
N
T
L
T
-
M
F
G
M
V
L
A
I
G
L
L
V
D
---
D
A
I
V
V
V
E
N
V
E
R
V
M
A
-
E
E
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
FGG
S
---
T
G
A
--
I
Y
R
Q
F
S
I
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
--
L
T
P
A
L
C
A
T
M
L
K
P
I
A
-----
K
G
D
H
G
E
-
G
----
K
KG
F
F
G
-------
W
F
N
R
M
F
E
K
S
T
H
H
-
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
-----
L
Y
L
I
I
V
V
G
M
A
Y
L
-
F
V
R
L
P
S
S
F
L
P
D
E
DQG
V
F
M
T
M
V
Q
L
P
-----
A
G
A
T
Q
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
TKEKNNVE
S
V
F
A
V
N
GFGFA
G
R
G
Q
N
T
G
I
A
F
V
--
S
L
K
D
W
A
D
R
P
G
EE
N
K
V
E
A
I
T
M
R
A
T
R
A
F
S
Q
I
--
K
D
--
A
M
V
-----------
F
A
-
F
N
L
P
A
I
V
E
L
G
----------
T
-
A
T
G
F
D
F
E
L
I
D
---------------------------------------------------------------
Q
----------
A
-
G
L
G
-
H
E
K
L
T
Q
A
R
N
Q
L
L
A
E
A
A
K
H
P
D
---------------------------------
M
L
T
S
V
--
R
P
N
G
L
E
D
----
T
P
--
Q
F
-
K
--------------
I
D
I
D
Q
E
K
-------
A
Q
----
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
-----
R
G
R
V
K
K
V
Y
V
M
S
EAKY
R
----------
M
L
P
D
D
I
G
D
W
Y
V
R
-
A
-
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
---
Y
G
-
S
P
R
L
E
R
Y
N
G
L
P
S
-
M
E
I
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
-
Q
L
A
S
----
K
L
P
T
G
--
V
G
Y
D
W
T
G
-
M
S
Y
Q
---------------
E
R
L
S
G
N
Q
A
P
S
L
Y
A
I
--
S
---
L
I
V
V
-
F
L
C
L
A
A
L
Y
E
S
W
S
I
P
F
S
--
V
M
L
V
V
P
L
G
V
I
G
A
L
L
-
A
A
T
F
---------
R
G
----
L
T
---
N
D
V
--
Y
F
Q
V
---
G
L
L
T
T
I
-
G
L
S
A
K
N
A
I
L
-
I
V
E
F
A
K
D
L
M
D
---
K
E-
G
K--
G
L
I
E
A
T
L
D
A
V
-
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
--
I
---
S
---
T
G
AG
S
G
A
Q
N
A
--
V
G
T
G
V
M
G
G
M
V
T
---
A
T
V
L
-
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
N
E
------
27
HHSearch
61.50
13%
-164
- C2 -
3AQP
-
SECDF_THET8
A:
[252-726]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
L
K
-----
V
A
E
I
R
A
I
----
G
P
T
L
G
Q
D
A
I
Q
--------
A
G
I
R
S
A
L
I
-----
G
-------------
T
L
A
I
F
L
L
--
I
F
A
Y
Y
G
-
P
H
L
G
L
-----
V
A
S
L
G
L
L
Y
T
S
A
L
I
-
L
G
L
L
--
S
G
L
G
A
------------
T
----
L
T
L
P
G
-
I
A
G
L
V
L
T
L
G
A
A
V
D
---
G
N
V
L
S
F
E
R
I
K
E
E
L
R
-
A
-
G
K
K
L
R
Q
A
I
P
E
G
F
R
H
S
T
L
T
I
M
D
V
N
I
A
H
L
L
A
A
A
A
L
----
Y
Q
---
Y
---
A
T
G
--
P
V
R
G
F
A
V
I
L
A
I
G
V
V
A
S
V
F
S
N
L
V
--
F
S
R
H
L
L
E
R
L
A
D
R
G
E
-----
I
R
P
P
M
W
-------------------
L
-------
V
D
-----
P
R
F
N
F
M
-
G
P
A
R
Y
V
T
A
-----
A
T
L
L
L
A
A
L
-
A
A
G
V
V
F
A
K
G
F
N
Y
S
I
---------------------------------
D
---------------
F
T
-------
G
-
G
---
T
A
Y
T
L
--
R
A
E
P
--
N
V
---------
E
V
E
T
L
R
R
F
L
E
E
K
--
G
F
--
P
G
K
-----------
E
A
V
I
T
Q
--------------------------------------------------------------------------------------------
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--------------
R
-------------------------------
E
--
F
L
V
K
L
P
P
--
L
S
D
E
---
R
R
L
E
L
E
R
L
F
A
S
E
L
K
----------
A
T
V
L
A
-
S
E
T
V
G
P
A
I
-----------
G
E
E
L
R
R
N
A
V
M
A
V
L
V
--
G
---
L
G
L
I
-
L
L
Y
V
A
F
R
F
-
D
W
T
F
G
V
A
--
S
I
L
A
V
A
H
D
V
A
I
V
A
G
-
M
Y
S
L
---------
L
G
----
L
E
---
F
S
I
--
P
T
I
A
---
A
L
L
T
I
V
-
G
Y
S
I
N
D
S
I
V
-
V
S
D
R
I
R
E
N
Q
K
---
L
LR
H
L--
P
Y
A
E
L
V
N
R
S
I
-
N
Q
T
L
S
R
T
V
M
T
S
L
T
T
L
L
P
I
L
A
L
L
--
F
---
L
---
G
G
---
S
V
L
R
D
--
F
A
L
A
I
F
V
G
I
F
V
---
G
T
Y
S
-
S
I
Y
V
V
S
A
L
V
V
A
W
K
N
R
------------
35
Fugue
58.54
11%
-121
- C2 -
1IWG
-
ACRB_ECOLI
A:
[7-1036]
DRP
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
LPVAQYPTIA
P
P
A
V
T
I
S
A
S
Y
P
GAD
A
K
T
V
Q
D
TVT
Q
V
I
E
Q
N
MNGIDNLM
Y
M
S
S
N
S
D
STG
T
V
Q
I
T
L
T
F
E
SGTD
A
D
I
A
Q
V
Q
V
Q
N
K
L
Q
L
A
MPLLP
Q
E
V
Q
Q
Q
G
V
S
V
E
K
S
SSSFLMVV
G
V
I
N
T
DGTMT
Q
E
D
I
S
D
Y
V
A
A
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
-------
Q
L
FGSQY
A
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
---
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
G
T
P
P
V
K
G
Q
Q
L
N
--
A
S
I
I
---
A
Q
T
R
L
T
S
T
E
E
F
G
K
I
L
L
K
V
N
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
YD
I
I
A
E
F
N
G
Q
P
A
S
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
---------------------------
A
K
M
E
P
F
F
-----
P
S
G
L
K
I
V
Y
P
YD
T
T
P
F
V
K
I
S
I
H
--------
E
V
V
K
T
L
V
E
-----
A
-------------
I
I
L
V
F
L
V
--
M
Y
L
F
L
Q
N
F
R
A
T
L
-----
I
P
T
I
A
V
P
V
V
L
L
G
T
-
F
A
V
L
--
A
A
F
G
F
------------
S
I
N
-----
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
---
D
A
I
V
V
V
E
N
V
E
R
V
M
A
E
E
-
G
L
P
P
K
E
A
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
AFFG
G
S
---
T
---
G
A
I
--
Y
R
Q
F
S
I
T
-
I
V
S
A
M
A
L
S
V
L
V
A
L
I
--
L
T
P
A
L
C
A
T
M
---
L
K
-----
F
G
W
F
N
R
-
M
----
F
----
E
-------
K
-------
S
T
H
H
-
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
-----
L
Y
L
I
I
V
V
G
-
M
A
Y
-
L
F
V
R
L
----
P
S
S
---------
F
L
P
-----
D
E
D
Q
G
-----------------------------------------
V
F
M
T
--
M
V
Q
L
P
A
G
A
T
Q
--
E
R
T
Q
K
V
L
N
E
V
T
H
Y
Y
L
T
K
--
E
K
NN
V
E
S
-----------
V
F
A
V
N
G
---------
F
-----
G
F
A
G
R
G
Q
N
T
G
I
A
F
V
S
L
------
K
D
W
A
D
R
--
P
G
E
E
N
K
V
E
-
A
I
T
M
R
A
T
R
-
A
F
-
S
---
Q
-
I
------
K
D
----
A
M
V
F
A
-
F
N
L
P
--------
A
-
I
V
E
-
L
G
T
A
T
G
F
D
F
E
L
I
D
Q
A
G
L
G
H
E
K
L
T
Q
A
R
----
N
Q
----------------
L
L
A
E
A
A
K
H
P
M
--
L
T
S
V
R
P
N
G
L
E
--------------------------------------
D
----
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
--
T
-----
T
L
G
A
A
WG--------
G
----------
S
Y
V
N
D
F
I
D
R
G
R
V
-
K
-
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
---
G
D
-
W
-
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
M
E
I
L
G
Q
A
A
P
G
K
S
--
T
G
E
A
M
E
L
-
M
E
Q
L
A
S
K
L
-----------
P
T
G
V
G
Y
D
W
S
G
N
Q
A
P
--
S
---
L
Y
A
I
-
S
L
I
V
V
F
L
C
---
L
A
A
L
Y
--
E
S
W
S
I
P
F
S
V
M
L
V
V
P
-
L
G
V
I
G
--
A
--
L
L
A
A
T
----
F
R
--
G
L
T
N
D
V
Y
F
Q
V
---
G
L
L
T
T
I
-
G
L
S
A
K
N
A
I
L
-
I
V
E
F
A
K
D
L
M
D
KEG
K
--
G
---
L
I
E
-
A
T
L
D
A
V
-
R
M
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
L
V
IS
T
---
G
---
A
G
---
S
G
A
Q
N
--
A
V
G
T
G
V
M
G
G
M
V
---
T
A
T
V
L
A
I
F
F
V
P
V
F
--------
F
V
V
V
R
R
R
F
S
R
K
11
PsiBlast_PDB
52.09
25%
-195
- C2 -
4MT1
-
?
A:
[858-1036]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
S
S
E
E
--------
A
K
G
G
S
Q
T
L
I
L
Y
G
L
A
-------------
V
A
A
V
F
L
V
--
L
A
A
L
Y
E
S
W
S
I
P
L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
T
-
G
R
N
L
F
E
G
L
L
G
S
------------
V
P
S
F
A
N
D
I
Y
F
Q
V
G
F
V
T
V
M
-
G
L
S
A
K
---
N
A
I
L
I
I
E
F
A
K
D
L
Q
A
-
Q
-
G
K
S
A
V
E
A
A
L
E
A
A
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
L
----
Y
I
---
A
---
A
G
A
S
S
A
S
Q
R
A
I
G
-
T
T
V
F
W
G
M
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
50.43
16%
-179
- C2 -
4DX5
6
ACRB_ECOLI
A:
[193-503]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
----
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
-
G
GTPPV
K
G
Q
Q
L
----------
N
A
S
I
I
A
Q
TRL-
T
S
T
E
E
F
G
K
I
L
L
K
V
N
-
Q
D
G
S
R
V
L
L
R
D
V
A
K
I
E
L
G
---
G
E
N
Y
D
I
I
A
E
F
N
G
Q
P
A
-
S
G
L
G
I
K
L
A
T
-
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
-
P
F
F
P
S
G
--
L
K
I
V
Y
P
Y
-
D
T
T
---
P
F
-----------
V
K
I
S
I
H
E
V
V
K
T
L
V
E
--
A
---
I
I
L
V
-
F
L
V
M
Y
L
F
L
Q
N
F
R
A
T
L
I
--
P
T
I
A
V
P
V
V
L
L
G
T
F
A
-
V
L
A
A
---------
F
G
----
F
S
---
I
N
T
--
L
T
M
F
---
G
M
V
L
A
I
-
G
L
L
V
D
D
A
I
V
-
V
V
E
N
V
E
R
V
M
A
---
E
E-
G
L--
P
P
K
E
A
T
R
K
S
M
-
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
A
--
F
FGG
S
---
T
G
---
A
I
Y
R
Q
--
F
S
I
T
I
V
S
A
M
A
L
---
S
V
L
V
-
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
--------
33
HHSearch
45.09
14%
-200
- C2 -
3AQP
-
SECDF_THET8
A:
[253-439]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
K
V
A
E
-
I
R
A
I
G
P
T
L
-----------
G
Q
D
A
I
Q
A
G
I
R
S
A
L
I
--
G
---
T
L
A
I
-
F
L
L
I
F
A
Y
Y
G
-
P
H
L
G
L
V
--
A
S
L
G
L
L
Y
T
S
A
L
I
L
G
-
L
L
S
G
---------
L
G
----
A
T
---
L
T
L
--
P
G
I
A
---
G
L
V
L
T
L
-
G
A
A
V
D
G
N
V
L
-
S
F
E
R
I
K
E
E
L
R
---
A
--
G
K--
K
L
R
Q
A
I
P
E
G
F
-
R
H
S
T
L
T
I
M
D
V
N
I
A
H
L
L
A
A
A
A
L
Y
--
Q
---
Y
---
A
T
---
G
P
V
R
G
--
F
A
V
I
L
A
I
G
V
V
A
---
S
V
F
S
-
N
L
V
F
S
R
H
L
L
E
R
L
A
D
R
G
E
I
R
P
-------
12
PsiBlast_PDB
44.52
25%
-232
- C2 -
4K0E
-
?
A:
[857-1009]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
I
L
P
M
---
V
L
A
L
M
F
V
L
L
F
G
E
F
K
N
L
R
Q
P
A
L
--
I
L
M
A
V
P
L
A
T
L
G
G
L
V
-
A
L
H
L
-------
R
G
M
-----
T
L
--
N
V
S
S
-
A
V
G
F
I
---
A
L
F
G
V
A
-
V
L
N
A
I
I
M
I
A
-
N
L
--------------
S
---
L
K
E
-
A
V
V
R
G
A
G
E
R
M
R
P
V
L
M
T
A
T
V
A
A
L
G
L
I
P
A
A
L
--
A
---
H
---
G
L
---
G
S
D
V
Q
R
P
L
A
T
V
V
V
G
G
L
I
T
A
T
A
L
T
L
V
L
L
P
-------------------------
6
PsiBlast_PDB
41.54
24%
-23
- C- -
3K8V
-
?
A:
[44-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
A
A
G
L
A
I
S
D
-
R
M
T
A
Q
I
K
G
-
L
T
-
Q
---
A
-
Q
------
R
N
----
A
N
D
G
I
-
S
L
A
Q
--------
T
-
A
E
G
A
L
G
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
----
D
R
----------------
D
A
L
Q
A
E
V
T
Q
L
--
Q
S
E
I
Q
R
V
A
E
Q
-
T
S
FN
G
Q
-
K
LLDGSFN
G
V
Q
F
QIG
A
-----
N
-------
A
G
----
E
T
I
G
V
S
K
I
M
N
A
Q
T
A
S
L
G
G
S
L
T
R
T
T
--
S
-----
T
I
D
A
T
-------------------------
D
L
T
K
-----
Y
-
D
T
A
M
A
A
G
D
L
T
I
N
G
V
D
V
G
---
K
--
I
D
A
A
S
T
A
Q
E
R
A
A
Q
L
T
E
A
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
39.89
25%
-223
- C2 -
4K0J
-
?
A:
[857-1009]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
A
V
I
L
P
M
---
V
L
A
L
M
F
V
L
L
F
-------
Q
P
A
L
--
I
L
M
A
V
P
L
A
T
L
G
G
L
V
-
A
L
H
L
-------
R
G
M
-----
T
L
--
N
V
S
S
-
A
V
G
F
I
---
A
L
F
G
V
A
-
V
L
N
A
I
I
M
I
A
-
N
L
-------------------
K
E
-
A
V
V
R
G
A
G
E
R
M
R
P
V
L
M
T
A
T
V
A
A
L
G
L
I
P
A
A
L
--
A
---
H
---
G
L
---
G
S
D
V
Q
R
P
L
A
T
V
V
V
G
G
L
I
T
A
T
A
L
T
L
V
L
L
P
-------------------------
7
PsiBlast_PDB
38.08
24%
-12
- C2 -
3K8W
-
?
A:
[44-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
A
A
G
L
A
I
S
D
-
R
M
T
A
Q
I
K
G
-
L
T
-
Q
---
A
-
Q
------
R
N
----
A
N
D
G
I
-
S
L
A
Q
--------
T
-
A
E
G
A
L
G
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
----
D
R
----------------
D
A
L
Q
A
E
V
T
Q
L
--
Q
S
E
I
Q
R
V
A
E
Q
-
T
S
FN
G
Q
-
K
LLDGSFN
G
V
Q
F
Q
IG
A
-----
N
-------
A
G
----
E
T
I
G
V
S
K
I
M
N
A
Q
T
A
S
L
G
G
S
L
T
R
T
T
--
S
-----
T
I
D
A
T
-------------------------
D
L
T
K
-----
Y
-
D
T
A
M
A
A
G
D
L
T
I
N
G
V
D
V
G
---
K
--
I
D
A
A
S
T
A
Q
E
R
A
A
Q
L
T
E
A
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
34.19
25%
-17
- C- -
2ZBI
-
?
A:
[62-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
Q
---
A
-
Q
------
R
N
----
A
N
D
G
I
-
S
L
A
Q
--------
T
-
A
E
G
A
L
G
E
I
S
N
N
L
Q
R
I
R
E
L
A
V
Q
A
S
N
G
T
N
T
Q
T
----
D
R
----------------
D
A
L
Q
A
E
V
T
Q
L
--
Q
S
E
I
Q
R
V
A
E
Q
-
T
S
FN
G
Q
-
K
LLDGSFN
G
V
Q
F
Q
I
G
A
-----
N
-------
A
G
----
E
T
I
G
V
S
K
I
M
N
A
Q
T
A
S
L
G
G
S
L
T
R
T
T
--
S
-----
T
I
D
A
T
-------------------------
D
L
T
K
Y
D
T
A
-
M
-
A
A
G
----
D
L
T
I
N
G
V
D
V
G
---
K
--
I
D
A
A
S
T
A
Q
E
R
A
A
Q
L
T
E
A
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
33.51
19%
-71
- C2 -
3JA6
-
MCP2_THEMA
G:
[223-503]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
M
K
D
-----------
V
Q
T
E
T
F
S
V
A
E
S
I
E
E
I
S
KANEE
I
T
N
Q
L
L
G
I
S
K
E
M
D
N
I
S
------
T
R
I
E
S
I
--
S
A
S
V
Q
E
T
T
-
A
G
S
E
E
I
S
S
-
A
T
-
K
---
N
I
A
------
D
S
----
A
Q
Q
A
A
-
S
F
A
D
QSTQLAKE
A
-
G
D
A
-
L
K
K
V
I
E
V
T
R
M
I
S
N
S
A
K
D
V
E
R
V
V
E
S
F
Q
KGAE
E
I
----------------
T
S
F
V
E
T
I
N
A
I
AE
Q
T
N
L
L
A
L
N
A
A
-
I
E
--
A
A
-
R
--------------
A
G----
E
-------
A
G
RGFA
V
V
A
D
E
I
R
K
L
A
E
E
S
Q
Q
A
S
E
N
V
R
R
V
V
--
N
-----
E
I
R
S
I
----------
A
----------
E
D
A
G
K
V
S
S
E
I
T
A
-
R
V
E
E
G
T
K
L
A
D
E
A
--
D
E
K
L
N
---
S
I
-
V
G
A
V
E
R
I
N
E
M
L
Q
N
I
A
A
A
I
------
E
E
Q
T
A
A
V
D
E
I
T
T
A
M
T
E
N
A
-----
K
N
--
A
E
E
I
T
N
S
-
V
K
E
V
N
A
R
L
-----------
Q
E
I
S
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
32.83
19%
-60
- C2 -
2CH7
2
MCP2_THEMA
A:
[3-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--
M
K
D
-----------
V
Q
T
E
T
F
S
V
A
E
S
I
E
E
I
S
K
A
N
E
E
I
T
N
Q
L
L
G
I
S
K
E
M
D
N
I
S
------
T
R
I
E
S
I
--
S
A
S
V
Q
E
T
T
-
A
G
S
E
E
I
S
S
-
A
T
-
K
---
N
I
A
------
D
S
----
A
Q
Q
A
A
-
S
F
A
D
Q
S
T
Q
L
A
K
E
A
-
G
D
A
-
L
K
K
V
I
E
V
T
R
M
I
S
N
S
A
K
D
V
E
R
V
V
E
S
F
Q
K
G
AE
E
I
----------------
T
S
F
V
E
T
I
N
A
I
A
E
Q
T
N
L
L
A
L
N
A
A
-
I
E
--
A
A
-
R
--------------
A
G----
E
-------
A
G
R
G
F
A
V
V
A
D
E
I
R
K
L
A
E
E
S
Q
Q
A
S
E
N
V
R
R
V
V
--
N
-----
E
I
R
S
I
----------
A
----------
E
D
A
G
K
V
S
S
E
I
T
A
-
R
V
E
E
G
T
K
L
A
D
E
A
--
D
E
K
L
N
---
S
I
-
V
G
A
V
E
R
I
N
E
M
L
Q
N
I
A
A
A
I
------
E
E
Q
T
A
A
V
D
E
I
T
T
A
M
T
E
N
A
-----
K
N
--
A
E
E
I
T
N
S
-
V
K
E
V
N
A
R
L
-----------
Q
E
I
S
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
32.01
26%
-109
- C1 -
4R04
-
TOXA_PEPDI
A:
[923-1088]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
E
H
I
T
K
E
I
S
T
I
K
N
S
I
I
T
D
V
N
G
--------
Q
L
D
H
T
S
Q
V
N
T
L
N
A
A
F
-----------
F
I
Q
S
L
I
D
Y
S
S
N
K
--------------
D
V
L
N
D
L
S
T
S
V
K
V
Q
L
Y
A
Q
L
F
S
T
G
L
N
T
I
Y
D
S
I
Q
-
L
V
N
L
I
S
N
A
--
V
N
D
T
I
----
N
V
L
P
T
I
T
E
-
G
I
P
I
V
---
S
-
T
I
L
D
-
G
I
N
L
G
A
A
I
K
E
L
L
D
E
H
D
P
L
L
K
---
K
--
E
---
L
E
---------
A
K
V
G
V
L
A
I
N
M
S
L
S
I
A
A
T
V
A
S
I
V
--
G
---
I
---
G
---------------------------------------------------------
5
PsiBlast_PDB
28.32
28%
-184
- C2 -
3WXW
-
ADR2_HUMAN
A:
[151-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
C
F
---
I
Y
L
I
V
I
C
V
L
G
I
A
A
I
I
V
S
Q
W
D
M
F
A
T
P
Q
Y
---
R
--
G
---
V
R
A
-
G
V
F
L
G
L
-
G
L
S
G
I
I
P
T
L
H
Y
V
I
S
E
G
F
L
K
A
A
T
--
I
--------
I
---
G
W
L
M
L
--
M
A
S
L
Y
I
T
G
A
A
L
---
Y
A
A
R
I
P
E
R
F
F
P
G
--------------------
43
Fugue
27.36
11%
-11
- C2 -
3G9G
-
SYP1_YEAST
A:
[1-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
Q
R
T
K
Y
A
D
---------
S
I
L
-----
T
T
K
S
P
Y
E
A
T
E
T
I
R
I
R
---------------
L
S
-------
Q
-
V
-
K
L
L
N
K
D
F
Y
L
L
F
K
E
L
A
N
L
K
R
--
N
Y
A
Q
Q
L
R
K
I
I
A
E
N
E
D
I
T
--
K
I
--
L
N
A
-----------
Q
M
I
E
S
N
V
L
T
P
Q
E
M
S
A
F
-----
R
F
N
S
L
G
E
L
R
N
V
W
D
T
V
I
------
E
E
L
K
S
D
--
L
K
S
S
T
E
Y
Y
-
N
T
L
D
Q
Q
V
--
V
R
-
E
---
L
-
K
------
E
S
----
V
E
N
N
T
-
S
W
R
E
--------
S
-
K
D
L
-
H
S
K
L
S
K
N
A
A
S
I
E
H
Y
S
K
N
N
E
N
S
S
H
L
E
E
----
A
R
----------------
R
Q
W
D
Q
Q
S
P
Y
L
--
F
E
L
F
E
T
I
D
Y
N
R
L
D
--
T
L
-
K
--------------
N
-----
C
-------
M
L
----
R
F
Q
T
S
F
S
D
Y
L
L
N
T
T
K
E
C
E
T
V
M
T
K
F
--
L
-----
A
F
E
P
Q
----------
S
----------
E
I
D
R
F
A
K
D
A
S
Q
Y
-
N
-
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------