@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu05780: (2016-06-09 )
MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRKWNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENIFQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGHINLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARALKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQKKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ
Atome Classification :
(22 SA)
--.........10..-.-.-....20........30........40........50.....----...-60..----------------....--------------------.---------------.------------70----........80........90----.--------.....----..100---...-.-..-..110........---------120.--...----..-------.------------.130-----------------.------..-...-.140-------------..--------.-....150.....----..160.-..-.....170......----..180.--.--.--.-------....190....---------------------------------------...200.......210.......220...---------------.----------------------------...230..-.-.----...240....-.-.---.--250....-----------...260---........270.......280-------------------........290-.....-..300-----------......------.310.......320...-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
E
I
S
D
I
IYG
Q
H
H
I
-
D
-
G
-
V
L
E
E
L
I
K
SA
P
V
Q
R
L
K
G
I
Y
QGG
A
S
F
L
V
NRKWN
V
T
R
Y
EHS
I
G
V
----
M
L
L
-
I
K
K
L----------------G
G
T
I
--------------------
E
---------------
E
------------
Q
I
----
A
G
L
L
H
D
V
S
H
T
A
F
S
H
V
V
D
V
V
F
----E--------N
Q
A
E
D
----
Y
H
E
N
----
I
F
Q
-
Q
-
V
I
-
V
HS-E
I
P
D
I
L
Q
KH---------G-Y
H
--
T
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E
----
L
L-------S------------DDS
R
-----------------
W
------
T
L
-LEQ-P
A
P
E
-------------LC--------A-DRTD
Y
T
L
R
D
M
Y
R
----YGHI-
N
-
L
H
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A
Q
T
F
L
D
-
H
L
I
VRN----GRMF-P--D--
S
--
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-------
E
A
A
E
W
F
V
S
V
Y
Y
---------------------------------------
K
E
V
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F
L
N
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G
Y
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L
A
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A
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H---------------D----------------------------VI
S
A
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D
L
L
-
K
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T
----
D
Q
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L
N
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RA-S-K---
N
--
E
E
V
L
S
L
L
-----------
T
SIHP----G
I
Q
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DDI
Q
Y
D
F
H
Q
KK
K
M
R
--------------------LIDP
S
I
F
LD
D
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-WIKSS-
G
V
S
E
K
-----------
V
R
K
M
G
E
------
A
A
Y
Q
K
AKK
G
V
Y
I
K
I
LKQ-----------
38
HHSearch
85.06
24%
-119
- C3 -
4MZ7
7
SAMH1_HUMAN
A:
[29-363]
--
K
V
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
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F
Q
R
L
R
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L
G
G
G
Y
Y
V
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H
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H
S
L
G
V
----
G
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L
-
A
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C
L
----------------
V
H
A
L
G
E
K
Q
PELQIS
E
R
D
V
L
-----
C
---------------
V
------------
Q
I
----
A
G
L
C
H
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L
G
H
G
P
F
S
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M
F
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F
----
I
PLARPEVK
W
T
H
E
Q
----
G
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M
----
M
F
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-
H
-
L
I
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S
N
-
G
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L
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--
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PLELWPYKGRPENK
S
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Y
------
E
I
-
V
S
N
-
K
R
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-------------
I
D
--------
V
-
D
K
W
D
Y
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D
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H
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----
L
G
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N
-
N
F
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DNE
L
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--
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-------
G
N
L
Y
D
M
F
H
T
R
N
---------------------------------------
S
L
H
R
R
A
Y
Q
H
K
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G
N
I
I
D
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M
I
T
D
A
F
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D
Y
I
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I
T
G
A
GG
K
K
Y
R
IST
A
----------------------------
I
D
D
M
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A
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K
L
-
T
----
D
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---
P
KL
K
D
A
R
E
I
L
-----------
K
Q
I
E
Y
----------------------------------------------------------------------------------------------------------------------
39
HHSearch
84.46
24%
-118
- C3 -
5AO0
4
SAMH1_HUMAN
A:
[99-458]
---
V
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
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L
R
Y
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L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
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S
L
G
V
----
G
Y
L
-
A
G
C
L
----------------
V
H
A
L
--------------------
G
E
K
Q
PELQIS
E
R
D
V
L
C
V
------------
Q
I
----
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
----
I
P
L
A
RPE
V
K
W
T
H
E
Q
----
G
S
V
M
----
M
F
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-
H
-
L
I
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N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
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E
D
I
C
F
I
K
-------
E
------------
Q
I
V
G
PLWPYKGRPENK
S
F
L
--
Y
------
E
I
-
V
S
N
-
K
R
N
G
-------------
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
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-
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A
R
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C
E
V
DN
E
L
R
I
C
-
A
--
R
--
D
KE
V
-------
G
N
L
Y
D
M
F
H
T
R
N
---------------------------------------
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
D
Y
I
E
I
T
G
A
GG
K
K
Y
R
IST
A
----------------------------
I
D
D
M
E
A
Y
T
K
L
-
T
----
D
N
I
F
L
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L
Y
S
-
T
-
D
---
P
KL
K
D
A
R
E
I
L
-----------
K
Q
I
E
Y
----------------------------------------------------------------------------------------------------------------------
36
HHSearch
83.78
26%
-122
- C3 -
2HEK
13
?
A:
[3-349]
--
K
E
F
S
D
P
L
Y
G
F
V
R
V
-
G
-
E
-
A
G
L
R
L
I
D
S
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P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
-
T
E
R
I
----------------
C
E
S
L
--------------------
K
VKE
K
E
L
---------
V
------------
K
L
----
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
V
L
L
----
P
R
E
------
R
S
H
E
D
----
F
T
E
R
----
V
------
I
-
K
E
T
-
E
I
Y
E
I
L
K
Q
----------
D
-
Y
S
--
H
E
D
I
E
R
-
L
V
-------
R
------------
I
T
L
G
-----------------
K
PED
E
E
E
K
L
L
S
E
I
-
I
T
G
E
-------------
F
G
--------
S
-
D
R
M
D
Y
L
R
R
D
A
Y
F
----
C
G
V
S
Y
G
-
F
F
-
D
Y
D
R
L
I
S
-
T
L
R
V
Y
E
----
N
K
V
V
-
V
--
D
--
E
--
S
G
L
-----
R
A
L
E
N
F
L
I
S
R
Y
---------------------------------------
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
L
I
S
Q
---------------
E
D---------------------------
F
T
D
I
N
N
F
L
R
L
-
N
----
D
A
F
V
I
S
E
L
F
K
-
R
-
K
---
A
----
F
R
E
D
F
-----------
E
R
I
F
Q
RKHF
K
T
L
L
S
T
--
E
N
Y
E
K
F
S
E
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K
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R
L
L
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FPQEK
V
R
F
D
E
V
E
K
E
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G
G
N
I
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V
L
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K
A
H
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L
S
P
L
-----------
I
A
S
L
K
P
------
I
---------------------------
26
Fugue
82.99
25%
-111
- C3 -
2HEK
13
?
A:
[1-369]
M
I
K
E
F
S
D
P
L
Y
G
F
V
R
V
-
G
-
E
-
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
-
T
E
R
I
----------------
C
E
S
L
--------------------
K
---------------
V
KE
K
E
L
V
------
K
L
----
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
V
L
L
----
P
--------
R
E
R
S
------
H
E
D
----
F
T
E
-
R
-
V
I
-
K
E
T
-
E
I
Y
E
I
L
K
Q
D
YS
H
E
D
I
E
R
L
V
-
R
I
--
T
L
G
----
K
P
-------
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------------
D
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-----------------
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L
-
S
E
I
-
I
T
G
E
-------------
F
G
--------
S
-
D
R
M
D
Y
L
R
R
D
A
Y
F
C
GVS
Y
G
F
F
-
D
-
Y
----
D
R
L
I
S
-
T
L
R
V
Y
E
----
N
K
V
V
-
V
DE
S
--
G
--
L
-------
R
A
L
E
N
F
L
I
S
R
Y
---------------------------------------
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
L
I
S
Q
E--------------
D
----------------------------
F
T
D
I
N
N
F
L
-
R
L
N
----
D
A
F
V
I
S
E
L
F
K
R
K
-
A
---
F
--
R
E
D
F
E
R
I
FQRKHFKTLLS
T
E
N
Y
E
----
K
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F
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Q
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Y
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G
N
I
Y
V
L
S
S
-
E
G
L
K
K
-----------
A
H
E
L
S
P
------
L
I
A
S
L
K
P
I
K
L
Y
R
I
Y
V
D
R
QL
W
E
K
A
R
S
E
L
K
40
HHSearch
80.26
23%
-116
- C3 -
2Q14
6
?
A:
[7-313]
--
K
I
I
N
D
P
V
F
G
F
I
N
I
-
P
-
K
G
L
L
Y
D
I
V
R
H
P
L
L
Q
R
L
T
R
I
K
Q
V
G
L
S
S
V
V
Y
P
G
A
Q
H
T
R
F
Q
H
S
L
G
A
----
F
Y
L
-
M
S
E
A
----------------
I
T
Q
L
T
S
K
G
N
F
I
F
D
S
E
A
E
-------
A
---------------
V
------------
Q
A
----
A
I
L
L
H
D
I
G
H
G
P
F
S
H
V
L
E
D
T
I
----
V
QG------
V
S
H
E
E
----
I
S
L
M
----
L
M
E
-
R
-
M
N
-----------
K
E
M
---------
N
-
G
Q
--
L
S
L
----
A
I
-------
Q
------------
I
F
K
D
EYP--------------
K
------
R
F
-
L
H
Q
L
V
S
G
Q
-------------
L
D
--------
M
-
D
R
L
D
Y
L
R
R
D
S
F
Y
----
T
G
V
T
-
E
G
N
I
-
G
S
A
R
I
I
K
-
M
L
D
V
A
D
----
D
R
L
V
-
I
--
E
--
S
KG
I
-------
Y
S
I
E
N
F
L
T
A
R
R
---------------------------------------
L
M
Y
W
Q
V
Y
L
H
K
T
S
V
A
Y
E
R
M
L
I
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T
L
L
R
A
K
E
L
---------------
A
S
Q
G
V
E
L
F
A
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P
A
L
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F
F
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Y
N
DIN
H
T
E
F
H
N
N
P
D
C
L
E
N
F
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Q
L
-
D
----
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D
I
W
T
A
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K
V
-
W
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NHP
D
--
K
V
L
S
T
L
S
-----------
L
G
M
I
N
----------------------------------------------------------------------------------------------------------------------
37
HHSearch
78.34
23%
-109
- C3 -
4LRL
5
?
A:
[38-355]
--
K
V
F
R
D
P
V
H
N
Y
I
H
V
-
Q
H
Q
-
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
----
Y
E
I
-
T
R
R
I
----------------
C
E
I
F
Q
R
NYSVERLGENGWNDDE
R
L
I
---------------
T
------------
L
C
----
A
A
L
L
H
D
V
G
H
G
P
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S
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T
F
E
H
I
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----
D
--------
T
N
H
E
A
----
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T
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Q
----
I
I
T
-
S
-
P
---
E
T
-
E
V
Y
Q
I
L
N
R
V
---------
S
A
D
F
--
P
E
K
----
V
A
-------
S
------------
V
I
T
K
-----------------
Q
YPN
P
--
Q
V
-
V
Q
M
-
I
S
S
Q
-------------
I
D
--------
A
-
D
R
M
D
Y
L
L
R
D
A
Y
F
----
T
G
T
E
-
Y
G
T
F
-
D
L
T
R
I
L
R
-
V
I
R
P
Y
K
----
G
G
I
A
-
F
--
A
MN
G
--
M
-------
H
A
V
E
D
Y
I
V
S
R
Y
---------------------------------------
Q
M
Y
V
Q
V
Y
F
H
P
V
S
R
G
M
E
V
I
L
D
H
L
L
H
R
A
K
E
L
---------------
F
E
NPE
F
D
Y
D
LQASLL
V
P
F
F
K
G--------
D
F
T
L
Q
E
Y
L
K
L
-
D
----
D
G
V
L
S
T
Y
F
T
Q
-
W
-
M
DVP
D
--
S
I
L
G
D
L
A
-----------
K
R
F
L
M
----------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.92
25%
-127
- C3 -
4QG4
6
SAMH1_HUMAN
A:
[42-259]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
H
D
L
G
A
G
P
F
S
H
M
F
D
G
R
F
----
I
--------
P
L
A
R
P
E
V
K
W
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPLE----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.23
24%
-112
- C3 -
4ZWE
6
SAMH1_HUMAN
A:
[6-223]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPLE----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.88
24%
-122
- C3 -
4TNY
6
SAMH1_HUMAN
A:
[6-223]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPLE----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
69.53
21%
-89
- C3 -
2Q14
6
?
A:
[5-407]
E
R
K
I
I
N
D
P
V
F
G
F
I
N
I
P
K
-
G
-
L
L
Y
D
I
V
R
H
P
L
L
Q
R
L
T
R
I
K
Q
V
G
L
S
S
V
V
Y
P
G
A
Q
H
T
R
F
Q
H
S
L
G
A
----
F
Y
L
M
S
E
A
I
----------------
T
Q
L
T
--------------------
S
---------------
K
G
N
F
I
F
D
S
E
A
E
A
V
Q
A
----
A
I
L
L
H
D
I
G
H
G
P
F
S
H
V
L
E
D
T
I
----
V
--------
Q
G
V
S
------
H
E
E
----
I
S
L
M
L
M
E
R
M
N
K
E
M
N
------
G
Q
---------
L
-
S
L
--
A
I
Q
----
I
F
-------
K
------------
D
E
Y
P
-----------------
K
------
R
F
-
L
H
Q
-
L
V
S
G
-------------
Q
L
--------
D
M
D
R
L
D
Y
L
R
R
D
S
F
Y
----
T
G
V
T
-
E
-
G
N
I
G
S
A
R
I
I
K
M
L
D
V
A
D
D
----
R
L
V
I
E
S
--
K
--
G
--
I
-------
Y
S
I
E
N
F
L
T
A
R
R
L
M
Y
W
QVYLH
K
T
S
V
A
Y
E
R
M
L
I
S
T
L
L
R
A
K
E
L
A
S
Q
G
V
E
L
F
A
S
P
A
L
H
F
F
L
Y
N
D
I
N
H
T
E
F
H
N
N
P
D
C
L
E
N
F
I
Q
L
---------------
D
----------------------------
D
N
D
I
W
T
A
L
-
K
-
V
W
SNH
P
D
K
V
L
S
T
L
S
L
-
G
M
I
---
N
--
R
N
I
F
K
V
E
-----------
N
S
A
E
P
----
I
G
E
D
R
I
K
E
L
T
L
Q
I
S
Q
Q
L
G
I
T
--------------------
L
S
E
A
N
Y
F
V
S
T
P
-
S
I
E
K
N
M
Y
D
P
A
D
DS
I
D
I
I
Y
KDG
T
I
K
N
I
A
E
ASDMLN
I
S
L
L
S
K
K
V
K
K
Y
Y
L
C
Y
Q
R
-----------
18
PsiBlast_PDB
69.16
24%
-118
- C3 -
4TNR
6
SAMH1_HUMAN
D:
[6-223]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
GYLA
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQISERDVLCV-
Q
I
----
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
IPLA
R
--------
P
E
V
K
W
----
T
H
E
Q
GSVM
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
FIKEQIVGPLE----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
SFLYEIVSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.73
24%
-118
- C3 -
4TNX
6
SAMH1_HUMAN
A:
[6-223]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPLE----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.81
25%
-123
- C3 -
5AO0
4
SAMH1_HUMAN
A:
[100-343]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGP------
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.74
24%
-114
- C3 -
4TNP
6
SAMH1_HUMAN
A:
[6-223]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPL-----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.11
24%
-117
- C3 -
4TNQ
6
SAMH1_HUMAN
A:
[6-223]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPLES---
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.21
25%
-94
- C3 -
2O6I
3
?
A:
[44-311]
----
V
H
N
Y
I
H
V
Q
H
Q
------
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
----
Y
E
I
-
T
R
R
I
C
E
I
F
Q
R
NYSVERLGEN
G
W
N
D
--------------------
D
---------------
E
------------
R
L
I
T
L
C
A
A
L
L
H
D
V
G
H
G
P
Y
S
H
T
F
E
H
I
F
----
D
--------
T
N
--------
H
E
A
----
I
T
V
-
Q
-
I
I
-
T
S
P
-
E
T
-
E
V
Y
Q
I
L
---------
N
-
R
V
--
S
A
D
----
F
P
-------
E
------------
K
V
A
S
-----------------
V
------
I
T
-
K
Q
Y
-
P
N
P
Q
-------------
V
V
Q
M
I
SSQID
A
-
D
R
M
D
Y
L
L
R
D
A
Y
F
----
T
G
------
T
-
E
Y
G
T
F
D
L
-
T
R
I
L
R
V
----
I
R
P
Y
-
K
--
G
--
G
--
I
AFAMNG
M
H
A
V
E
D
Y
I
V
S
R
Y
---------------------------------------
Q
M
Y
V
Q
V
Y
F
H
P
V
--------
S
R
G
M
E
V
I
L
D
H
---------------
L
----------------------------
L
H
R
A
K
E
L
F
-
E
-
N
----
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.84
25%
-94
- C3 -
4LRL
4
?
A:
[44-300]
----
V
H
N
Y
I
H
V
Q
H
Q
------
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
----
Y
E
I
-
T
R
R
I
C
E
I
F
Q
R
NYSVERLGEN
G
W
N
D
--------------------
D
---------------
E
------------
R
L
I
T
L
C
A
A
L
L
H
D
V
G
H
G
P
Y
S
H
T
F
E
H
I
F
----
D
--------
T
N
--------
H
E
A
----
I
T
V
-
Q
-
I
I
-
T
S
P
-
E
T
-
E
V
Y
Q
I
L
---------
N
-
R
V
--
S
A
D
----
F
P
-------
E
------------
K
V
A
S
-----------------
V
------
I
T
-
K
Q
Y
-
P
N
P
Q
-------------
V
V
Q
M
I
SSQID
A
-
D
R
M
D
Y
L
L
R
D
A
Y
F
----
T
G
------
T
-
E
Y
G
T
F
D
L
-
T
R
I
L
R
V
----
I
R
P
Y
-
K
--
G
--
G
--
I
A
F
A
MNG
M
H
A
V
E
D
Y
I
V
S
R
Y
---------------------------------------
Q
M
Y
V
Q
V
Y
F
H
P
V
--------
S
R
G
M
E
V
I
L
D
H
---------------
L
----------------------------
L
H
R
A
K
E
L
F
-
E
-
N
----
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.72
25%
-123
- C3 -
5AO2
3
SAMH1_HUMAN
A:
[26-268]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
A
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
----
D
I
-------
C
F
I
K
E
Q
I
VGPL-----
L
-----------------
W
------
P
Y
-
K
G
R
-
P
E
N
K
S
F
L
Y
E
I
VSNKRNG
I
D
--------
V
-
D
K
W
D
Y
F
A
R
D
C
H
H
----
L
G
I
Q
-
N
-
N
F
-
D
Y
K
R
F
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.32
25%
-95
- C3 -
3IRH
3
?
A:
[44-299]
----
V
H
N
Y
I
H
V
Q
H
Q
------
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
----
Y
E
I
-
T
R
R
I
C
E
I
F
Q
R
NYSVERLGEN
G
W
N
D
--------------------
D
---------------
E
------------
R
L
I
T
L
C
A
A
L
L
H
D
V
G
H
G
P
Y
S
H
T
F
E
H
I
F
----
D
--------
T
N
--------
H
E
A
----
I
T
V
-
Q
-
I
I
-
T
S
P
-
E
T
-
E
V
Y
Q
I
L
---------
N
-
R
V
--
S
A
D
----
F
P
-------
E
------------
K
V
A
S
-----------------
V
------
I
T
-
K
Q
Y
-
P
N
P
Q
-------------
V
V
Q
M
I
SSQID
A
-
D
R
M
D
Y
L
L
R
D
A
Y
F
----
T
G
------
T
-
E
Y
G
T
F
D
L
-
T
R
I
L
R
V
----
I
R
P
Y
-
K
--
G
--
G
--
I
A
F
A
MNG
M
H
A
V
E
D
Y
I
V
S
R
Y
---------------------------------------
Q
M
Y
V
Q
V
Y
F
H
P
V
--------
S
R
G
M
E
V
I
L
D
H
---------------
L
----------------------------
L
H
R
A
K
E
L
F
-
E
-
N
----
P
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.43
30%
-136
- C3 -
4MZ7
6
SAMH1_HUMAN
A:
[31-182]
----
I
N
D
P
I
H
G
H
I
E
L
-
H
-
P
-
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
-
V
H
A
L
----------------
G
E
K
Q
--------------------
P
---------------
E
LQIS
E
R
D
V
L
C
V
-
Q
I
----
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
G
R
F
IPLA
R
--------
P
E
V
K
W
----
T
H
E
Q
G
S
V
M
M
F
E
-
H
-
L
I
-
N
S
N
-
G
I
K
P
V
M
E
Q
Y
---------
G
-
L
I
--
P
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.94
33%
-109
- C3 -
2HEK
12
?
A:
[4-174]
---
E
F
S
D
P
L
Y
G
F
V
R
V
-
G
-
E
-
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
-
T
E
R
I
----------------
C
E
S
L
--------------------
K
VKE
K
E
L
---------
V
------------
K
L
----
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
V
L
L
----
P
--------
R
--
E
R
----
S
H
E
D
----
F
T
E
-
R
-
V
I
-
K
E
T
-
E
I
Y
E
I
L
K
Q
D
---------
Y
-
S
H
E
D
I
E
R
----
L
V
R
I
T
L
GKP
E
------------
D
E
E
E
-----------------
K
------
L
L
-
S
E
I
-
I
T
G
E
-------------
F
G
--------
S
-
D
R
M
D
Y
L
R
R
D
A
Y
F
----
C
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
58.61
33%
-112
- C3 -
2HEK
14
?
B:
[4-174]
---
E
F
S
D
P
L
Y
G
F
V
R
V
-
G
-
E
-
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
----
Y
H
I
-
T
E
R
I
----------------
C
E
S
L
--------------------
K
VKEKEL---------
V
------------
K
L
----
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
V
L
L
----
P
--------
R
--
E
R
----
S
H
E
D
----
F
T
E
-
R
-
V
I
-
K
E
T
-
E
I
Y
E
I
L
K
Q
D
---------
Y
-
S
H
ED
I
E
R
----
L
V
RITLGKP
E
------------
D
E
E
E
-----------------
K
------
L
L
-
S
E
I
-
I
T
G
E
-------------
F
G
--------
S
-
D
R
M
D
Y
L
R
R
D
A
Y
F
----
C
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------