@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06220: (2016-06-09 )
MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWKGCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASWSDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQKRSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYHSTQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHPAEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAIGNAYSPK
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........--20.-----.......30-.........40........50......-..60........70........80........------90--....----..--------.--..100.......110.......120--------...------...-.-.-------.130------.....-----------..140.....----..150.......160...---....170----.---.......180.......190.....------..200.......210.......220.......-230.-......240....---...250-----.......260...-....270.......280.--------......290.....-..300.......---310.......320.......330-........340------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNEG
Y
I
I
A
G
L
L
L
L
T
A
G
M
I
D
--
F
L
W
-----
T
T
L
W
LESG--A
G
P
I
T
R
C
L
S
A
W
L
W
K
G
C
R
KISG
D
H
A
K
V
L
-
S
MA
G
P
L
L
L
C
L
T
L
V
I
W
I
S
L
F
WS
G
W
V
L
I
YSSD
P
H
------
S
---
L
M
E
T----QS--------K--EPASWS
D
R
I
Y
F
S
G
Y
V
M
F
T
LGNGD----------LAP------NGG-
L
-
W
-------
K
L
V
T
------
I
I
ETA-----------Q
G
L
L
T
I
T
F
S
V
----
T
Y
L
I
S
V
L
S
A
V
N
Q
K
R
S
F
A
Q
---
S
V
L
SLG-----H---D
G
T
E
I
V
H
NAWNGKDFHD
I
D
F
L
L
V
AA------SS
E
L
G
K
L
TAQHNA
F
P
I
L
H
F
YHSTQHQES
S
I
I
A
-
V
A
V
L
-
D
E
A
L
T
I
F
KYGIPE---QYQP
N
Q
-----
L
H
I
K
E
A
R
S
S
I
K
N
Y
-
L
D
T
V
H
T
A
YIH
P
A
EQAPPE--------P
D
I
S
K
L
Q
Q
SGIPAL-SKQ
T
F
Q
I
A
V
N
S
I
---
K
E
R
R
Q
L
L
L
G
I
I
Q
AGARKWP
V
Q
E
--
Q
AIGNAYSPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
67.57
21%
-68
- C6 -
3F3K
3
SHB17_YEAST
A:
[3-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
P
R
C
I
I
V
R
H
G
-------------
Q
T
E
W
S
K
S
G
QY
T
G
L
T
D
L
P
L
T
------------
P
Y
G
E
G
Q
M
L
R
T
G
E
S
V
F
R
N
Q
-----
F
L
N
P
D
N
I
T
Y
I
F
T
S
P
R
L
------
R
---
A
R
Q
T
----
V
D
--------
L
V
L
K
P
L
S
D
E
Q
R
A
K
I
R
V
V
V
D
D
D
L
R
E
W
E
----------
Y
G
D
------
Y
E
G
M
L
-
T
-------
R
E
I
I
------
E
L
R
K
S
-----------
R
G
L
---------------------
D
K
E
R
P
W
--------
N
I
W
-----
R
---
D
G
C
E
------
N
G
E
T
T
Q
Q
I
G
L
R
L
S
R
A
------
I
A
R
I
Q
N
L
H
R
K
H
Q
S
------------
E
G
R
A
S
D
I
M
V
F
A
H
-
G
H
A
L
R
Y
F
A
A
I
W
F
G
---
L
G
V
Q
K
K
-----
C
E
T
I
E
E
I
Q
N
V
K
S
Y
D
D
D
T
V
P
Y
V
K
L
E
S
Y
R
H
L
V
D
N
--------
P
-
C
F
L
L
D
A
G
G
I
G
V
L
-
S
Y
A
H
H
N
I
------------------------
D
E
P
A
L
E
--
L
A
G
P
F
V
S
P
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
63.22
16%
-83
- C5 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKIK
G
D
I
T
V
E
N
V
H
F
T
Y
PSRPDVPILRG
M
N
L
R
V
N
AGQT
V
A
L
V
G
S
SGCG
K
S
T
I
I
S
L
L
L
RYYDVL
K
G
K
I
T
I
DGVDVRDIN
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
NCT
I
E
E
N
I
S
L
G
KEGIT
R
E
E
M
V
A
A
C
K
M
A
NA
E
K
F
I
K
T
L
PNGYNTLVGDR
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
RNPK
I
L
L
L
D
EATSALDAES
E
G
I
V
Q
Q
A
L
D
K
A
A
KG
R
T
T
I
I
I
A
HRLSTIRNAD
L
I
I
S
C
K
NGQVV
E
V
G
D
H
R
A
L
M
A
Q
QG
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
--
Y
L
L
-----
N
T
C
A
Y
R
M
G
--
L
A
L
I
I
T
--
D
P
P
T
M
Q
P
M
R
V
L
R
V
M
Y
A
I
T
I
-
S
T
S
T
L
G
F
A
T
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
K
I
------
S
---
K
I
D
S
----
L
S
--------
L
--
A
----
G
E
K
K
K
L
Y
G
K
V
I
F
K
--
N
V
R
----------
F
A
Y
------
P
E
R
-----------------------
P
E
I
-----------
E
I
L
K
G
L
S
F
S
V
----------------
E
P
G
Q
T
L
---
A
L
V
G
P
S
-----
G
---
C
G
K
S
T
V
V
A
L
L
E
R
F
-
Y
D
T
L
G
G
E
I
F
I
D
------
G
S
E
I
K
T
L
N
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
D
C
S
I
A
E
-
N
I
I
----------
Y
G
L
D
-------
P
S
S
-----
V
T
M
A
Q
V
E
E
A
A
R
L
--------
A
N
I
H
N
F
I
A
E
L
P
E
--------
G
F
E
T
R
V
G
D
R
G
T
Q
L
S
-
G
G
Q
K
Q
R
I
A
I
A
R
A
---
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
--
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
60.03
11%
-115
- C2 -
2P67
5
ARGK_ECOLI
A:
[2-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SL
I
N
E
A
T
L
A
E
S
I
R
R
L
R
Q
G
E
R
A
--
T
L
A
-----
Q
A
M
T
L
V
E
S
--
R
H
P
R
H
Q
A
L
S
T
Q
L
L
D
A
I
M
P
Y
C
G
-
N
T
L
R
L
-
G
V
T
G
T
P
G
------
A
G
K
S
T
F
L
E
A
F
G
M
L
L
I
R
E
G
L
------
K
---
V
A
V
I
----
A
V
--------
D
--
P
S
---
N
D
L
A
R
A
E
A
A
F
I
R
P
V
P
S
G
A
----------
S
Q
R
------
A
R
E
-
L
-
M
-------
L
L
C
E
A
A
GYD
V
V
I
V
E
T
-----------
V
G
V
G
Q
S
E
T
E
V
----
A
R
M
V
D
C
F
I
S
L
Q
I
A
Q
G
I
K
K
---
G
L
M
E
V
A
---------------------------
D
L
I
V
I
N
K
------
D
D
G
D
N
H
T
N
V
A
I
A
R
H
M
Y
E
S
A
L
H
I
L
R
R
K
Y
D
E
---------------
W
Q
P
R
V
L
T
---
C
S
A
L
E
K
-----
R
G
I
D
E
I
W
H
A
I
I
D
F
-
K
T
A
L
T
A
S
---
G
R
L
Q
Q
V
R
Q
--------
Q
Q
S
V
E
W
L
R
K
Q
T
E
E
E
-
V
L
N
H
L
F
A
N
E
D
F
D
---
R
Y
Y
R
Q
T
L
L
A
V
K
N
N
T
L
S
P
R
T
G
L
R
--
Q
L
S
E
F
I
Q
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
58.65
10%
-95
* C6 *
1B0P
1
POR_DESAF
A:
[1-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G
K
K
M
M
T
T
D
G
N
T
A
T
A
H
V
A
Y
A
M
--
S
E
V
-----
A
A
I
Y
P
I
T
P
--
S
S
T
M
G
E
E
A
D
D
W
A
A
Q
G
R
K
N
I
F
G
Q
T
L
T
I
R
-
E
--------------------------
M
Q
S
E
A
------
G
---
A
A
G
A
----
V
H
--------
G
--
A
L
A
A
--------
G
A
L
T
T
T
F
T
A
S
---------------------
Q
G
-
L
-
L
-------
L
M
I
P
------
N
M
Y
K
I
-----------
S
G
E
-
L
L
P
G
V
F
----
H
V
T
A
R
A
I
A
A
H
A
L
S
I
F
G
D
H
---
Q
D
I
Y
A
A
-----
R
---
Q
T
G
F
A
M
L
A
S
S
S
V
Q
E
A
H
D
M
A
L
V
A
H
L
A
------
A
I
E
S
N
--------
V
P
F
M
H
F
F
D
G
------------------------
F
R
T
S
H
---
E
I
Q
K
I
E
-----
V
L
---
D
Y
A
D
M
A
S
L
-
V
N
Q
K
A
L
A
E
F
R
A
K
S
M
N
P
E
H
--------
P
---------
H
V
R
G
-
T
A
Q
N
P
D
I
Y
F
Q
G
R
---
E
A
A
N
P
Y
Y
L
K
V
P
G
I
V
A
E
Y
M
Q
K
V
A
--
S
L
T
G
R
S
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
56.77
12%
-120
- C5 -
3ZGY
-
?
A:
[19-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
P
V
T
V
I
G
L
G
L
M
G
Q
A
L
A
G
--
A
F
L
G
A
GHP
T
T
V
W
N
R
T
A
--
A
P
L
V
A
--------
R
G
A
K
S
-
A
G
S
V
A
E
A
V
-
A
A
------------------
S
P
L
V
V
V
C
V
S
D
Y
D
------
A
---
V
H
A
L
----
L
D
--------
P
--
L
D
G
T
-----
A
L
Q
G
R
T
L
V
N
L
T
S
G
T
----------
S
A
Q
------
A
R
E
-
R
-
A
-------
A
W
A
D
------
G
----------------------
R
G
A
----
D
Y
L
D
G
A
I
L
A
G
P
A
A
I
G
T
A
D
---
A
V
V
L
L
S
G
P
RSA
F
---
D
P
H
A
S
A
L
G
G
L
G
A
G
T
T
Y
L
G
A
D
H
G
L
A
S
------
L
Y
D
A
A
G
L
V
M
M
W
S
I
L
N
--
G
F
L
Q
G
A
A
L
L
G
T
A
G
V
D
-
A
T
T
F
-
A
P
F
I
T
Q
G
I
G
T
V
A
D
---
W
L
P
G
Y
A
-----
R
Q
I
D
D
G
A
Y
P
A
D
D
A
-
A
I
D
T
H
L
A
T
M
E
H
L
I
H
E
S
E
F
--------
L
G
V
N
-------------------
A
E
L
P
---
R
F
I
K
A
L
A
D
R
A
V
A
D
G
--
H
G
G
S
G
Y
--
P
A
L
I
E
Q
F
R
T
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
56.59
13%
-114
- C4 -
2BG9
-
?
C:
[1-484]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
E
E
E
--
R
L
I
-----
N
D
L
L
I
V
N
K
--
Y
N
K
H
V
R
P
V
K
H
N
N
E
V
V
N
I
A
L
S
L
T
L
S
N
L
I
-
S
L
K
E
T
D
E
-
T
L
T
T
N
V
W
M
D
H
A
W
Y
D
H
R
L
T
W
N
A
S
E
Y
------
S
---
D
I
S
I
----
L
R
--------
L
--
R
----
P
E
L
I
W
I
P
D
I
V
L
Q
N
N
N
D
G
Q
YNVAYF
C
N
V
L
V
R
P
------
N
G
Y
-
V
T
W
-------
L
P
P
A
------
I
F
R
S
S
CPINVLYFPFD
W
Q
N
C
S
L
K
F
T
A
LNYN
A
N
E
I
S
M
D
L
I
I
D
P
E
A
F
T
E
N
GEW
E
I
I
H
K
P
-----
A
---
K
K
N
I
Y
G
D
K
F
P
N
G
T
N
Y
Q
D
V
T
F
Y
L
I
I
R
R
K
P
LFY
V
I
N
F
I
T
P
C
V
L
I
S
F
L
A
A
L
A
F
Y
L
P
A
E
S
G
E
K
M
S
T
A
-
I
C
V
L
--
L
A
Q
A
V
F
L
L
L
T
S
Q
---
R
L
P
E
T
A
L
A
V
PL
I
G
K
Y
L
M
F
I
M
S
L
V
T
-
G
V
V
V
N
C
G
I
V
L
N
F
H
F
R
T
P
S
THS
G
I
D
S
T
N
Y
I
V
K
Q
I
K
E
K
N
A
Y
D
-
E
E
V
G
N
W
N
L
V
G
Q
T
---
I
D
R
L
S
M
F
I
I
T
P
V
M
V
L
G
T
I
F
I
F
V
--
M
G
N
F
N
R
P
P
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
52.49
20%
-136
- C7 -
4LP8
8
IRK10_MAGMG
A:
[41-145]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
-
T
V
S
W
P
V
F
I
T
-
L
I
T
G
L
Y
L
V
T
N
A
L
F
A
L
A
Y
L
A
C
G
D
------
V
---
I
E
-------
N
--------
A
--
R
P
G
S
F
T
D
A
F
F
F
S
V
Q
T
M
A
T
I
G
Y
G
K
----------
L
I
P
------
I
G
P
-
L
-
A
-------
N
T
L
V
------
T
L
E
A
L
-----------
C
G
M
L
G
L
A
V
A
A
----
R
L
I
Y
A
R
F
T
R
P
T
A
G
V
L
F
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
52.17
18%
-106
- C3 -
4QOY
-
?
C:
[5-886]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNDVD
P
I
E
T
R
D
W
L
Q
A
I
E
S
V
I
R
E
EG
V
E
R
A
Q
Y
L
I
D
Q
L
L
A
E
A
R
KGGVNVAAGTGISNYINTIPVEEQPEYPGN
L
E
L
E
R
R
I
R
S
A
I
R
W
N
A
I
M
T
V
L
R
A
S
K
K
DLEL
G
G
H
M
A
S
F
Q
S
S
A
T
I
Y
D
V
C
F
N
HFFRARNEQDGGDLVYFQGHI
S
P
G
V
Y
A
R
A
F
L
E
GRLT
Q
E
Q
L
D
N
FRQEVHGNGLSSYPHPKLMPEFWQFPTVSMG
L
G
P
I
G
A
I
Y
Q
A
K
F
L
K
Y
L
E
H
R
GLKDTSK
Q
T
V
Y
A
F
L
G
D
G
E
M
D
E
P
E
S
K
G
A
I
T
I
A
T
R
E
K
L
D
N
L
V
F
V
-----
I
N
C
N
L
Q
R
L
--
D
G
P
V
T
---------
G
N
G
K
I
I
N
E
L
E
G
I
F
-
E
G
A
G
---
W
N
V
I
K
V
M
W
----
G
S
R
W
D
E
L
L
R
K
D
T
S
------
G
---
K
L
I
Q
----
L
M
--------
N
--
E
T
V
-------
D
G
D
Y
Q
T
F
K
S
K
D
G
A
----------
Y
V
R
------
E
H
F
-
F
-
G
-------
K
Y
P
E
------
T
A
A
L
V
-----------
A
D
-----
W
T
D
----
E
Q
I
W
A
L
N
R
G
G
H
D
P
K
K
I
Y
A
---
A
F
K
K
A
Q
-----
E
TKG
K
A
T
V
I
L
A
H
T
I
K
G
Y
G
M
G
D
A
A
I
A
H
Q
V
K
------
K
M
N
M
D
G
V
R
H
I
R
D
R
F
N
------------------
V
P
V
S
-
D
A
D
I
E
K
L
P
Y
I
T
F
P
---
E
G
S
E
E
H
-----
T
Y
L
H
A
Q
R
Q
K
L
H
G
Y
-
L
P
S
R
Q
P
N
F
T
E
K
L
E
-
L
P
S
L
--------
Q
D
F
G
A
L
L
E
E
Q
S
K
E
I
S
T
T
I
A
F
V
R
A
L
N
V
M
L
K
N
K
S
I
K
D
R
L
V
P
I
I
A
D
E
A
R
T
F
G
M
E
G
L
F
R
Q
I
G
-
I
Y
S
P
N
GKEDEKGQILQEGIN
E
L
G
A
G
C
S
W
L
A
A
A
T
SYSTNN
L
P
M
I
P
F
Y
I
Y
YSMFGFQRI
G
D
L
C
W
A
A
G
D
Q
Q
A
R
G
F
L
I
GGTSGRTTLNGEGLQHEDGH
S
H
I
Q
S
L
T
IPN
C
I
S
Y
D
P
AY
A
Y
E
V
A
V
I
M
H
D
G
L
E
R
M
YGEKQEN
V
Y
Y
Y
I
T
T
L
NEN
Y
H
M
P
A
M
PEGA
E
E
G
I
R
K
GIYKL
E
T
I
E
G
SK
G
K
V
Q
L
L
G
S
G
SI
L
R
H
V
R
E
A
A
E
I
L
A
KDYG
V
G
S
D
V
Y
S
V
TS
F
T
E
L
A
R
D
G
Q
D
C
E
R
W
N
M
L
H
PLET
P
R
V
P
Y
I
A
Q
V
M
ND
A
P
A
V
A
S
T
DYM
K
L
F
A
E
Q
VRTYVPAD
D
Y
R
V
L
GTD
G
F
G
R
S
D
S
R
E
N
L
R
H
H
F
EVD
A
S
Y
V
V
V
A
A
L
G
E
L
A
K
R
GEID
K
K
V
V
A
D
A
I
A
K
F
NIDADKVNPRLA
41
HHSearch
48.36
14%
-138
- C7 -
3SYA
5
?
A:
[38-152]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
D
L
K
W
R
F
N
L
L
-
I
F
V
M
V
Y
T
V
T
W
L
F
F
G
M
I
W
W
L
I
A
Y
I
R
GDMD
H
---
I
E
D
P
SWTP
C
V
--------
T
--
N
L
N
G
F
V
S
A
F
L
F
S
I
E
T
E
T
T
I
G
Y
G
Y
RV--------
I
T
D
------
K
C
P
-
E
-
G
-------
I
I
L
L
------
L
I
Q
S
V
-----------
L
G
S
I
V
N
A
F
M
V
----
G
C
M
F
V
K
I
S
Q
P
K
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
47.31
16%
-116
- C7 -
2QKS
5
KCNJ3_MOUSE
A:
[36-137]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
V
-
D
L
K
W
R
W
F
F
V
-
S
L
A
V
L
F
L
L
L
N
T
A
F
A
T
L
Y
M
L
G
S
A
------
P
---
I
-------
A
N
--------
Q
--
F
P
A
G
F
G
G
A
F
F
F
S
V
E
T
L
A
T
V
G
Y
G
D
----------
M
H
P
------
Q
T
V
-
Y
-
A
-------
H
W
I
A
------
T
L
E
I
F
-----------
V
G
M
S
S
I
A
L
A
T
----
G
C
A
F
I
K
M
S
Q
P
K
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
44.46
19%
-85
- C7 -
1P7B
4
?
A:
[66-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
A
L
F
V
V
N
N
T
L
F
A
L
L
Y
Q
L
G
D
A
------
P
---
I
-------
A
N
--------
Q
--
S
P
P
G
F
V
G
A
F
F
F
S
V
E
T
L
A
T
V
G
Y
G
D
----------
M
H
P
------
Q
T
V
-
Y
-
A
-------
H
A
I
A
------
T
L
E
I
F
-----------
V
G
M
S
G
I
A
L
S
T
----
G
L
V
F
A
R
F
A
R
P
R
A
K
I
M
F
A
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
43.73
22%
-138
- C7 -
3OUF
6
?
A:
[31-93]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
P
I
D
A
L
Y
F
S
V
V
T
L
T
T
V
G
Y
G
D
----------
F
S
P
------
Q
T
D
-
F
-
G
-------
K
I
F
T
------
I
L
Y
I
F
-----------
I
G
I
G
L
V
F
G
F
I
----
H
K
L
A
V
N
V
Q
L
P
S
I
L
S
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
42.84
20%
-168
- C7 -
4BW5
4
KCNKA_HUMAN
A:
[201-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
A
L
E
S
I
Y
F
V
V
V
T
L
T
T
V
G
F
G
D
----------
F
V
A
------
G
G
N
-
A
-
G
INYR
E
W
Y
K
P
L
V
------
W
F
W
I
L
-----------
V
G
L
A
Y
F
A
A
V
L
----
S
M
I
G
D
W
L
R
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
41.43
22%
-194
- C7 -
4WFE
5
KCNK4_HUMAN
A:
[223-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
K
L
E
A
I
Y
F
V
I
V
T
L
T
T
V
G
F
G
D
----------
Y
V
A
GA
D
P
R
Q
D
S
P
-
A
-
Y
-------
Q
P
L
V
------
W
F
W
I
L
-----------
L
G
L
A
Y
F
A
S
V
L
----
T
T
I
G
N
W
L
R
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
40.94
27%
-169
- C1 -
1LMM
-
TXP1_PSACA
A:
[1-40]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
I
P
K
W
--
K
G
C
V
N
R
H
G
D
C
-------------
C
E
G
L
E
C
W
K
R
R
--
R
S
F
E
V
C
V
P
K
T
P
K
------
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
38.85
16%
-127
- C7 -
5A6E
-
KCNT1_CHICK
B:
[256-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
C
L
V
F
T
G
T
C
G
I
Q
H
L
E
R
-------------------
A
--------
G
--
E
K
L
S
L
F
K
S
F
Y
F
C
I
V
T
F
S
T
V
G
Y
G
D
----------
V
T
P
------
K
I
W
-
P
-
S
-------
Q
L
L
V
------
V
I
M
I
C
-----------
V
A
L
V
V
L
P
L
Q
F
----
E
E
L
V
Y
L
W
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
38.83
13%
-151
- C7 -
3SPC
5
KCJ12_CHICK
A:
[40-155]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
D
I
R
W
R
Y
M
L
L
-
L
F
S
L
A
F
L
V
S
W
L
L
F
G
L
I
F
W
L
I
A
L
------
I
H
GD
L
E
N
P
----
G
G
DDTFKPCV
L
--
Q
V
N
G
F
V
A
A
F
L
F
S
I
E
T
Q
T
T
I
G
Y
G
F
RC--------
V
T
E
------
E
C
P
-
L
-
A
-------
V
F
M
V
------
V
V
Q
S
I
-----------
V
G
C
I
I
D
S
F
M
I
----
G
A
I
M
A
K
M
A
R
P
K
K
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
38.74
14%
-87
- C7 -
3EFF
-
?
K:
[37-117]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
V
L
L
A
G
S
Y
L
A
V
L
A
E
R
------
G
---
A
-------
P
G
--------
A
--
Q
L
I
T
Y
P
R
A
L
W
W
S
V
E
T
A
T
T
V
G
Y
G
D
----------
L
Y
P
------
V
T
L
-
W
-
G
-------
R
L
V
A
------
V
V
V
M
V
-----------
A
G
I
T
S
F
G
L
V
T
----
A
A
L
A
T
W
F
V
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
37.83
39%
-124
- C7 -
1TMO
-
TORA_SHEMA
A:
[98-143]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
G
H
K
S
N
T
H
Q
R
G
D
F
R
F
-
V
R
V
T
W
D
K
A
L
T
L
F
K
H
S
L
D
E
V
Q
T
Q
Y
G
P
S
G
-----
L
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
35.92
26%
-131
- C7 -
3LDC
4
MTHK_METTH
A:
[27-80]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
W
T
V
S
L
Y
W
T
F
V
T
I
A
T
V
G
Y
G
D
----------
Y
S
P
------
H
T
P
-
L
-
G
-------
M
Y
F
T
------
C
T
L
I
V
-----------
L
G
I
G
T
F
A
V
A
V
----
E
R
L
L
E
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------