@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06310: (2016-06-10 )
MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPGAVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVIVIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVTIIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIVAIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEHIGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQAIVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPEALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRKVSEKAAANPVTQQQPDILP
Atome Classification :
(20 SA)
.........10........-----20........30........40........50....-....60........70-........80.....--..-.90.......-.-100...---....110.----......120--.-.-----.----.---.---....130.-------......140.......150......-----.--160...-...-----.170..--.....---180.-.......190.-..-..--...200--....-....210.......220.......230.......-240--.......250.....---..--------260--------------...-.---.---.---------------..270......--.--280.......290.......300.......310......-----.320.......330.......340.......350..---......360-....--------....370------------......-----..380....------...390......--------.-----400---.......----.410......-.420.......430.......440.......450.......460.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNQ
S
Q
S
G
L
K
K
E
L
K
T
RH
M
T
M
-----
I
S
I
A
G
V
IGA
G
L
F
VGSG
S
V
I
HSTG
P
G
A
V
V
S
Y
A
L
A
G
L
L
-
V
I
F
I
M
R
M
LGEMSAVNP-TSG
S
F
S
Q
Y
A
H
DAIGP--WA-G
F
T
I
G
W
L
Y
W
F
-
F
-
W
V
I
V
I
A
---
I
E
A
IAG
A
G
----
I
I
Q
Y
W
FH----D-
I
-----
P
----
L
---
W
---
L
T
S
L
I
L
T
I
-------
V
L
T
L
T
N
V
Y
S
V
KSFG
E
F
E
Y
W
F
S
L
I
K
V
-----
V
--
T
I
I
A
F
L
-
I
V
G
-----
F
A
F
I
F
G--FAPGS---EP-V-GFSNLTGKG-G-FF-
P
E
--
G
I
S
S
V
---
L
L
G
I
-
V
V
V
I
F
S
FMG
T
E
I
V
A
I
AAGETSN
P
I
E
S
V
T
K
A
T
R
S
V
-
V
W
R
--
I
I
V
F
Y
V
G
S
I
A
I
V
V
A
L---LP--------WN---------------SAN-I---L---E---------------
S
P
F
V
A
V
L
E
HIG--V--
P
A
A
A
Q
I
M
N
F
I
V
L
T
A
V
L
S
C
L
NS
G
L
Y
T
T
S
R
M
L
Y
S
L
A
ERNEA-----
P
R
R
F
M
K
LSKKGVP
V
Q
A
I
V
A
G
T
F
F
S
Y
I
A
V
V
M
N
Y-FSP---
D
T
V
F
L
F
L
V--NSS
G
--------
A
I
A
L
L
V
-------------
Y
L
V
I
A
V
-----
S
Q
L
K
M
R
K
K
L
------EKTNP
E
A
L
K
I
K
M
--------
W
-----
L
F
----
P
F
L
T
Y
L
T
----
I
I
A
I
C
G
I
L
V
S
-
M
A
F
I
D
S
M
R
D
E
L
L
L
T
G
V
I
T
G
I
V
L
I
S
Y
L
V
F
R
K
RKVSEKAAANPVTQQQPDILP
25
Fugue
90.01
17%
-168
- C1 -
3GIA
7
Y609_METJA
A:
[3-435]
------
L
K
N
K
K
L
S
L
W
E
A
V
S
-----
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N-
I
I
-
T
G
A
L
S
I
L
L
W
M
-
S
-
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
----
Y
F
L
P
L
I
N
APIN
T
-
F
-----
N
----
I
---
A
---
I
T
E
I
G
I
V
A
-------
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
-----
L
--
I
L
G
L
F
I
-
F
A
G
-----
L
I
T
I
H
----
P
S
Y
V
---
I
P
-
D
-------------
L
A
-
P
S
--
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
-
I
L
I
--
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
---
L
P
--------
I
D
---------------
E
L
I
-
K
A
--
S
---
E
---------------
N
A
L
A
V
A
A
K
P
F
L
--
G
--
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
-----
P
E
F
F
E
R
K
V
W
F
K
S
T
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
N
-----------
M
E
G
V
A
--
S
I
T
S
--------
A
V
F
M
V
I
-------------
Y
L
F
V
I
L
-----
S
H
Y
I
L
I
D
E
V
------
G
G
R
-----------------
K
-----
E
I
----
V
I
F
S
F
I
V
----
V
L
G
V
F
L
L
L
L
Y
-
Y
Q
W
I
T
N
R
F
V
F
Y
G
I
I
A
T
F
I
G
V
L
I
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
N
M
Y
V
K
S
--------
1
PsiBlast_PDB
88.57
26%
-142
- C1 -
3OB6
1
ADIC_ECOLI
A:
[15-334]
----------------
V
T
L
-----
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
-
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
-
W
I
G
A
I
A
---
M
V
V
I
-
G
V
G
----
Y
L
S
Y
F
F
-------------
P
----
I
---
L
---
K
D
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
------
A
V
-----
A
--
T
V
L
A
L
I
P
I
V
G
-----
I
A
-
V
F
G
WF
W
F
R
G
E
---
T
Y
-
M
-
A
A
W
N
V
S
G
L
G
-
T
-
F
---
G
--
A
I
Q
S
T
---
L
----
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
-
V
L
I
--
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
---
I
P
--------
N
A
---------------
A
L
R
-
V
---
S
---
A
---------------
S
P
F
G
D
A
A
R
M
A
L
--
G
--
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
-----
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
88.24
20%
-155
- C1 -
3L1L
2
ADIC_ECO57
A:
[7-380]
--------
A
H
K
V
G
L
I
P
V
T
L
-----
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
L
A
S
-
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
-
A
-
C
W
I
G
N
I
---
A
M
V
V
I
G
V
G
----
Y
L
S
Y
F
F
P
----
I
-
L
K----
D
----
P
---
W
V
L
T
I
T
C
V
V
V
L
W
-------
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
V
A
T
V
L
A
L
-----
I
--
P
I
V
G
I
A
-
V
F
G
-----
W
F
W
F
R
G
-------------
E
-
T
Y
M
A
------------------
A
I
---
Q
S
T
L
-
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
-
V
L
I
--
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
---
I
P
--------
N
A
---------------
A
L
R
-
V
---
S
---
A
---------------
S
P
F
G
D
A
A
R
M
A
L
--
G
--
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
-----
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
I
V
G
I
L
M
T
I
F
Q
L
S
S
I
S
P
N
A
---
T
K
E
F
G
L
V
S
--
S
V
S
V
--------
I
F
T
L
V
P
-------------
Y
L
Y
T
C
A
-----
A
L
L
L
L
G
H
G
H
------
F
--------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.90
25%
-150
- C1 -
3L1L
2
ADIC_ECO57
A:
[15-328]
----------------
V
T
L
-----
M
V
S
G
A
I
M
G
S
G
V
F
L
L
P
A
N
-
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
-
W
I
G
N
I
A
---
M
V
V
I
-
G
V
G
----
Y
L
S
Y
F
F
P
----
I
-
L
-----
K
D
P
W
V
L
---
T
---
I
T
C
V
V
V
L
W
-------
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
------
A
V
-----
A
--
T
V
L
A
L
I
P
I
V
G
-----
I
A
-
V
F
G
W
F
W
F
R
G
E
---
T
Y
-
M
-
A
------------------
A
I
Q
S
T
---
L
----
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
-
V
L
I
--
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
---
I
P
--------
N
A
---------------
A
L
R
-
V
---
S
---
A
---------------
S
P
F
G
D
A
A
R
M
A
L
--
G
--
D
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
-----
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
85.57
19%
-202
- C1 -
4DJK
-
GADC_ECOLI
A:
[12-457]
----------
Q
L
T
L
L
G
F
F
A
-----
I
T
A
S
M
V
M
A
--
V
Y
E
Y
P
--
T
F
A
T
S
G
F
S
L
V
F
F
L
L
L
G
G
I
L
W
F
I
P
V
G
L
C
A
A
E
M
A
T
V
D
G
W---
G
V
F
A
W
V
S
N
T
L
G
P
--
R
W
-
G
F
A
A
I
S
F
G
Y
L
-
Q
-
I
A
I
G
F
I
P
M
L
Y
F
V
L
G
A
L
S
----
Y
I
L
K
W
-
P
----
A
-
L
NEDP
I
T
----
K
---
T
---
I
A
A
L
I
I
L
W
-------
A
L
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
-----
L
--
L
P
A
F
I
L
-
I
A
L
-----
A
A
I
Y
L
H
-------------------------
T
-
F
F
P
D
F
--
S
K
V
G
T
---
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
-
M
V
A
--
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
---
I
P
--------
G
N
---------------
E
I
N
-
L
---
S
A
G
V
M
---------------
Q
T
F
T
V
L
M
S
H
V
A
--
P
EI
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
-----
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
N
T
G
G
---
G
N
N
M
S
F
L
I
A
L
A
L
T
V
--------
V
I
Y
L
C
A
-------------
Y
F
M
L
F
I
-----
G
Y
I
V
L
V
L
K
H
------
P
D
-
L
--
K
R
T
F
N
I
--------
P
-----
G
G
K
G
V
K
L
V
V
A
I
V
G
----
L
L
T
S
I
M
A
F
I
V
-
S
F
L
P
-----------------------------------------------
14
HHSearch
85.48
19%
-162
- C1 -
3GIA
6
Y609_METJA
A:
[3-370]
------
L
K
N
K
K
L
S
L
W
E
A
V
S
-----
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
--
N
I
I
T
G
A
L
S
I
L
L
W
M
-
S
-
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
----
Y
F
L
P
L
I
N
----
A
P
I
-----
N
----
T
F
N
I
A
---
I
T
E
I
G
I
V
A
-------
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
-----
L
--
I
L
G
L
F
I
-
F
A
G
-----
L
I
T
I
H
-----------------
P
S
Y
---
V
I
-
P
D
L
A
-
P
S
--
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
-
I
L
I
--
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
---
L
P
--------
I
D
---------------
E
L
I
K
A
---
S
---
E
---------------
N
A
L
A
V
A
A
K
P
F
L
--
G
--
N
L
G
F
L
L
I
S
I
G
A
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
-----
P
E
F
F
E
R
K
V
W
F
K
S
T
-
E
G
L
Y
I
T
S
A
L
G
V
L
F
A
L
L
F
----------
N
M
E
G
V
A
--
S
I
T
S
--------
A
V
F
M
V
I
-------------
Y
L
F
V
I
L
-----
S
H
Y
I
L
I
D
E
V
------
G
--------------------------------------------------------------------------------------------------------
27
Fugue
82.48
16%
-173
- C1 -
4DJK
-
GADC_ECOLI
A:
[12-501]
-
Q
L
T
L
L
G
F
F
A
I
T
A
S
M
V
M
A
V
-----
Y
E
Y
P
T
F
A
T
S
G
--------------
F
S
L
V
F
F
L
L
L
G
G
I
-
L
W
F
I
P
V
G
L
C
A
A
E
M
A
T
V
-
D
G
W
G
V
F
A
W
V
S
N
T
L
G
P
--
R
W
-
G
F
A
A
I
S
F
G
Y
L
-
Q
-
I
A
I
G
F
I
---
P
M
L
Y
F
V
L
G
----
A
L
S
Y
I
L
K
----
W
-
P
-----
A
----
L
-------------------------
N
E
D
P
I
T
K
T
I
A
A
L
I
I
L
W
A
L
A
L
T
Q
-----
F
GG
T
K
Y
T
A
R
-
I
A
K
-----
V
G
F
F
A
G
I-
L
L
P
A
F
---
I
L
-
I
-
A
L
A
A
I
Y
L
H
T
-
F
-
F
P
-
D
F
--
S
K
V
G
T
---
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
-
M
V
A
--
A
I
C
L
S
S
V
G
G
L
S
I
A
M
V
---
I
P
--------
G
N
---------------
E
I
N
-
L
SA
G
V
---
M
---------------
Q
T
F
T
V
L
M
S
H
V
A
PE
I
--
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
-----
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
L
T
-
N
T
G
GG
N
N
M
S
F
L
I
A
L
--
A
L
T
V
--------
V
I
Y
L
C
A
-------------
Y
F
M
L
F
I
-----
G
Y
I
V
L
V
L
K
-------
H
P
D
L
K
R
T
F
N
I
P
G
--------
G
-----
K
-----
G
V
K
L
V
V
A
----
I
V
G
L
L
T
S
I
M
A
-
F
I
V
S
F
L
P
P
D
N
I
Q
G
D
S
T
D
M
Y
V
E
L
L
V
V
S
F
L
V
V
L
A
L
P
F
I
L
Y
A
V
H
F
F
L
H
P
R
A
R
S
P
2
PsiBlast_PDB
79.65
26%
-138
- C1 -
3LRB
-
ADIC_ECO57
A:
[15-328]
----------------
V
T
L
-----
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
-
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
-
W
I
G
N
I
A
---
M
V
V
I
-
G
V
G
----
Y
L
S
Y
F
F
-------------
P
----
I
---
L
---
K
D
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
------
A
V
-----
A
--
T
V
L
A
L
I
P
I
V
G
-----
I
A
-
V
F
G
W
F
W
F
R
G
E
---
T
Y
-
M
-
A
A
W
N
V
S
G
L
G
-
T
-
F
---
G
--
A
I
Q
S
T
---
L
----
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
-
V
L
I
--
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
---
I
P
--------
N
-------------------------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
-----
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.17
26%
-134
- C1 -
3LRC
-
ADIC_ECO57
A:
[15-328]
----------------
V
T
L
-----
M
V
S
G
N
I
M
G
S
G
V
F
L
L
P
A
N
-
L
A
S
T
G
G
I
A
I
Y
G
W
L
V
T
I
I
G
-
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
P
-
S
P
G
G
S
Y
A
Y
A
R
R
C
F
G
P
--
F
L
-
G
Y
Q
T
N
V
L
Y
W
L
A
C
-
W
I
G
N
I
A
---
M
V
V
I
-
G
V
G
----
Y
L
S
Y
F
F
-------------
P
----
I
---
L
---
K
D
P
L
V
L
T
I
T
C
V
V
V
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
------
A
V
-----
A
--
T
V
L
A
L
I
P
I
V
G
-----
I
A
-
V
F
G
WF
W
F
R
G
E
---
T
Y
-
M
-
A
A
W
N
V
S
G
L
G
-
T
-
F
---
G
--
A
I
Q
S
T
---
L
----
N
V
T
L
W
S
F
I
G
V
E
S
A
S
V
A
A
G
V
V
K
N
P
K
R
N
V
P
I
A
T
I
G
G
-
V
L
I
--
A
A
V
C
Y
V
L
S
T
T
A
I
M
G
M
---
I
P
--------
N
-------------------------------------------------------------
T
A
G
A
I
V
S
F
C
A
A
A
G
C
L
G
S
L
G
G
W
T
L
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
F
-----
P
P
I
F
A
R
V
N
K
A
G
T
P
V
A
G
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.97
21%
-150
- C1 -
3GIA
5
Y609_METJA
A:
[3-314]
-----------
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
-
G
-
A
L
S
I
L
L
W
M
-
S
-
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
N
A
P
I
N
----
T
-
F
-----
N
----
I
---
A
---
I
T
E
I
G
I
V
A
-------
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
-------------
L
-
I
L
G
-----
L
F
I
F
A
G
--
L
I
T
I
H
---
P
S
-
Y
-
V
I
P
D
L
A
---------
P
S
--
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
-
I
L
I
--
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
---
L
P
I
D
E
L
I
K
A
S
E
N
---------------
A
L
A
-
V
---
A
---
A
---------------
K
P
F
L
G
N
L
G
F
L
L
--
I
--
S
I
G
A
-------
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
-----
P
E
F
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.72
21%
-151
- C1 -
3GI8
-
Y609_METJA
C:
[2-314]
----------
E
L
K
N
K
K
L
S
L
WEAVS
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
NI
I
T
-
G
-
A
L
S
I
L
L
W
M
-
S
-
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
YFLP
L
I
N
A
P
I
N
----
T
-
F
-----
N
----
I
---
A
---
I
T
E
I
G
I
V
A
-------
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
-----------
I
--
V
L
V
A
L
L
-
I
L
G
-----
L
F
I
F
A
G
--
L
I
T
I
H
---
P
S
-
Y
-
V
I
P
D
L
A
---------
P
S
--
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
-
I
L
I
--
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
---
L
P
IDELIKAS
E
N
---------------
A
L
A
-
V
---
A
---
A
---------------
K
P
F
L
G
N
L
G
F
L
L
--
I
--
S
I
G
A
-------
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
-----
P
E
F
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.61
21%
-145
- C1 -
3GI9
-
Y609_METJA
C:
[2-314]
----------
E
L
K
N
K
K
L
S
L
W
E
A
V
S
M
A
V
G
V
M
I
G
A
S
I
F
S
I
F
G
V
G
A
K
I
A
G
R
N
L
P
E
T
F
I
L
S
G
I
Y
-
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
V
-
S
N
A
G
P
I
A
F
I
H
K
A
I
G
D
N
I
I
T
-
G
-
A
L
S
I
L
L
W
M
-
S
-
Y
V
I
S
I
A
---
L
F
A
K
G
F
A
G
Y
F
L
P
L
I
-
A
P
I
N
----
T
-
F
-----
N
----
I
---
A
---
I
T
E
I
G
I
V
A
-------
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
F
I
V
L
V
K
L
-------------
L
-
I
L
G
-----
L
F
I
F
A
G
--
L
I
T
I
H
---
P
S
-
Y
-
V
I
P
D
L
A
---------
P
S
--
A
V
S
G
M
---
I
F
A
S
-
A
I
F
F
L
S
Y
M
G
F
G
V
I
T
N
A
S
E
H
I
E
N
P
K
K
N
V
P
R
A
I
F
I
S
-
I
L
I
--
V
M
F
V
Y
V
G
V
A
I
S
A
I
G
N
---
L
P
I
D
E
L
I
K
A
S
E
N
---------------
A
L
A
-
V
---
A
---
A
---------------
K
P
F
L
G
N
L
G
F
L
L
--
I
--
S
I
G
A
-------
L
F
S
I
S
S
A
M
N
A
T
I
Y
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
L
-----
P
E
F
F
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.67
24%
-191
- C1 -
4DJI
-
GADC_ECOLI
A:
[142-434]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
A
G
I
--
L
L
P
A
F
I
-
L
I
A
-----
L
A
A
I
Y
L
--
H
S
G
------
A
-
I
-
E
M
D
S
K
T
------
F
F
-
P
D
---
F
S
K
V
GT-
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
--
I
C
L
S
S
V
G
G
L
S
I
A
M
-
V
---
I
P
--------
G
N
---------------
E
I
N
-
L
SA
G
V
---
M
---------------
Q
T
F
T
V
L
M
S
H
V
A
PE
I
--
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
-----
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
---------------
L
T
--
N
T
G
G
GN
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
-----
K
H
P
D
L
K
R
T
F
------
N
I
P
G
G
K
G
V
K
L
---------------------------------
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
---------------------------------------------
6
PsiBlast_PDB
67.10
24%
-193
- C1 -
4DJK
-
GADC_ECOLI
A:
[142-454]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
Q
F
G
G
T
K
Y
T
A
R
I
A
K
V
G
F
F
AG
I
--
L
L
P
A
F
I
-
L
I
A
-----
L
A
A
I
Y
L
--
H
-----------------
T
------
F
F
-
P
D
---
F
S
K
V
GT-
L
V
V
F
-
V
A
F
I
L
S
Y
M
G
V
E
A
S
A
T
H
V
N
E
M
S
N
P
G
R
D
Y
P
L
A
M
L
L
L
M
V
A
A
--
I
C
L
S
S
V
G
G
L
S
I
A
M
-
V
---
I
P
--------
G
N
---------------
E
I
N
-
L
SA
G
V
---
M
---------------
Q
T
F
T
V
L
M
S
H
V
A
PE
I
--
E
W
T
V
R
V
I
S
A
L
L
L
L
G
V
L
A
E
I
A
S
W
I
V
G
P
S
R
G
M
Y
V
T
A
Q
K
N
L
L
-----
P
A
A
F
A
K
M
N
K
N
G
V
P
V
T
L
V
I
S
Q
L
V
I
T
S
I
A
L
I
I
---------------
L
T
--
N
T
G
G
G
N
N
M
S
F
L
I
A
L
A
L
T
V
V
I
Y
L
C
A
Y
F
M
L
F
I
G
Y
I
V
L
V
L
-----
K
H
P
D
L
K
R
T
F
------
N
I
P
G
G
K
G
V
K
L
---------------------------------
V
V
A
I
V
G
L
L
T
S
I
M
A
F
I
V
S
---------------------------------------------
28
Fugue
56.78
13%
-131
- C1 -
3DH4
4
?
A:
[52-518]
A
G
K
S
L
P
W
-------
W
A
V
G
A
-----
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
-
L
A
I
A
S
Y
E
W
M
S
A
I
-
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
-
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
--
K
L
-
K
T
I
L
A
V
F
W
I
S
-
L
-
Y
I
F
V
N
L
---
T
S
V
L
Y
L
G
G
----
L
A
L
E
T
I
L
----
G
-
I
-----
P
----
L
---
M
---
Y
S
I
L
G
L
A
L
-------
F
A
L
V
Y
S
I
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
-----
T
--
T
Y
M
A
V
S
-
F
I
G
GTDG
W
F
A
G
V
S
K
--
M
V
D
A
A
---
P
G
-
H
-
F
E
M
I
L
D
Q
S
N
-
P
-
Q
Y
-
M
N
LP
G
I
A
V
L
---
I
G
G
L
-
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
E
A
Q
K
G
I
V
F
A
-
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
---
I
T
--------
S
D
---------------
P
Q
L
-
M
---
A
---
S
L
GDIAATNLPSAANA
D
K
A
Y
P
W
L
T
Q
F
L
--
P
--
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
SPDSG
D
H
K
L
V
N
V
G
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
M
L
G
G
-------
I
---
G
Q
A
F
Q
Y
I
Q
--
E
Y
T
G
LV------
S
P
G
I
L
A
-------------
V
F
L
L
G
L
FWKKT
T
S
K
G
A
I
I
G
V
------
V
A
S
I
P
F
A
L
F
L
K
F
--------
M
PLSMP
F
M
----
D
Q
M
L
Y
T
L
----
L
F
T
M
V
V
I
A
F
T
-
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
-
12
PsiBlast_PDB
47.42
29%
-168
- C1 -
5CI7
4
ULK1_HUMAN
A:
[101-193]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
D
L
A
D
Y
L
H
A
-
M
R
T
-
L
S
E
---
D
T
I
R
L
F
L
Q
--
Q
I
A
G
--------
A
M
R
L
L
H
-------------
S
K
G
I
I
H
-----
R
D
L
K
P
Q
N
I
L
L
S
N
PAG
R
R
A
N
P
N
S
I
R
V
K
I
--------
A
-----
D
F
----
G
F
A
R
Y
L
Q
SNMM
A
A
T
L
C
G
S
P
M
Y
-
M
A
-------------------------------------------------
10
PsiBlast_PDB
47.42
29%
-161
- C1 -
4WNO
1
ULK1_HUMAN
A:
[101-193]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
D
L
A
D
Y
L
H
A
-
M
R
T
-
L
S
E
---
D
T
I
R
L
F
L
Q
--
Q
I
A
G
--------
A
M
R
L
L
H
-------------
S
K
G
I
I
H
-----
R
D
L
K
P
Q
N
I
L
L
S
N
PAG
R
R
A
N
P
N
S
I
R
V
K
I
--------
A
-----
D
F
----
G
F
A
R
Y
L
Q
SNMM
A
A
T
L
C
G
S
P
M
Y
-
M
A
-------------------------------------------------
11
PsiBlast_PDB
47.03
29%
-163
- C1 -
4WNP
3
ULK1_HUMAN
A:
[101-193]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
D
L
A
D
Y
L
H
A
-
M
R
T
-
L
S
E
---
D
T
I
R
L
F
L
Q
--
Q
I
A
G
--------
A
M
R
L
L
H
-------------
S
K
G
I
I
H
-----
R
D
L
K
P
Q
N
I
L
L
S
N
PAG
R
R
A
N
P
N
S
I
R
V
K
I
--------
A
-----
D
F
----
G
F
A
R
Y
L
Q
SNMM
A
A
T
L
C
G
S
P
M
Y
-
M
A
-------------------------------------------------
17
HHSearch
45.49
10%
-118
- C1 -
3DH4
3
?
A:
[51-358]
------
K
A
G
K
S
L
P
W
W
A
V
G
A
-----
S
L
I
A
A
N
I
S
A
E
Q
F
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
-
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
K
--
G
I
Y
T
I
P
E
F
V
E
K
R
F
N
K
--
K
L
-
K
T
I
L
A
V
F
W
I
S
-
L
Y
I
F
V
N
L
T
---
S
V
L
Y
L
G
G
L
----
A
L
E
T
I
L
G
----
I
-
P
-----
L
----
M
---
Y
---
S
I
L
G
L
A
L
F
-------
A
L
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
-----
L
--
G
G
F
M
T
T
-
Y
M
A
-----
V
S
F
I
G
G
--
T
D
G
W
F
AGV
S
K
M
V
D
A
A
P
G
H
F
E
M
I
L
D
-
Q
S
N
P
Q
YM
N
L
P
G
I
AVL
I
G
G
L
W
V
A
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
A
K
S
V
S
-
E
A
Q
K
G
I
V
F
A
-
A
F
L
--
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
YVI
T
S
--------
D
P
QLMASLGDIAATNLP
S
A
A
-
N
---
A
---
D
---------------
K
A
Y
P
W
L
T
-
Q
F
L
--
P
--
V
G
V
K
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
-----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
40.05
27%
-186
- C1 -
4AJT
-
ZPI_MOUSE
A:
[160-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
F
N
L
S
K
K
Y
-
F
D
I
---
E
Y
V
S
I
N
F
Q
--
N
S
S
Q
--------
A
R
G
L
I
N
-------------
H
C
I
V
K
E
-----
T
E
G
K
I
P
K
L
F
------
D
E
I
N
P
E
T
K
L
I
L
V
D
Y
V
L
F
K
G
K
W
-----
L
T
----
P
F
-----------------------------------------------------------------------