@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06330: (2016-06-10 )
MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLLEDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIMGNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYPLPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNVRADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQYLAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30......---------------.----------------.-------------40-------------.-........50........60-------------------------------..-..--....70.------.......80.....--...-90...-------------.-.--...100----..---......110..-----------...------------.-----------.120---........--.130.--------.-------.....140.......150...-----.--------...160.....--..170....-....-180-.......190.--.-...--..200-....--....210-..----.---.---...220.......230....---------...---------240-----.........250--........260..-..------...270.......280..---.....290.......300.....-..310.--......320--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
A
Y
Q
E
D
L
H
P
L
L
G
K
A
V
E
H
I
N
R
V
MVGKR
D
I
A
I
L
S
L
A
A
L
L
---------------A----------------K-------------G--------------
H
-
V
L
L
EDVPGV
G
K
T
M
M
V
R
A
L
A
K
-------------------------------
S
I-GA--D
F
K
R
I
Q
F------TPDLLPSDVT
G
V
S
I
--
Y
N
A
-
K
T
M
E
F
-------------E-Y--RPG
P
I
-----MG---
N
I
V
L
A
DEINRT-----------SP
K
------------
T
-----------
Q
S
-----
A
L
L
E
A
M
EE--G
S
V
T
V--------D-------G
H
T
M
QLAD
P
F
F
V
M
ATQNPVEY-----E--------GTYPL
P
E
A
Q
L
D
--
R
F
L
F
-
K
L
RM-GYPS-FNE-EL
D
V
L
S
LQEKS--H-
P
I
E
--
T
L
E
P
--
V
IAK--E
D
F
I
F
L
Q
-
R
E
----
V
---
Q
---NVRAD
D
S
I
K
E
Y
I
V
E
I
V
Q
K
TR---------QHP---------
S
-------
V
Q
LGVSPR
G
S
I
---
A
L
M
K
A
A
Q
A
Y
A
L
L
H-HR------DYVIPD
D
I
Q
Y
LAPFTLP
H
---
R
M
M
LHPEAKFEG
I
Q
A
E
A
I
V
R
E
I
M
-
S
A
VKVP--VQRSAVR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
88.81
41%
-138
- C1 -
2R44
12
?
A:
[11-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
Y
Y
R
N
K
I
K
E
V
I
D
E
V
G
K
V
V
V
G
Q
K
Y
M
I
N
R
L
L
I
G
I
C
---------------
T
----------------
G
-------------
G
--------------
H
-
I
L
L
E
G
V
P
G
L
A
K
T
L
S
V
N
T
L
A
K
-------------------------------
T
M
-
D
L
--
D
F
H
R
I
Q
F
------
T
P
D
L
L
P
S
D
L
I
G
T
M
I
--
Y
N
Q
-
H
K
G
N
F
-------------
E
-
V
--
K
K
G
P
V
-----
F
S
---
N
F
I
L
A
D
E
V
N
R
S
-----------
P
A
K
------------
V
-----------
Q
S
-----
A
L
L
E
C
M
Q
E
--
K
Q
V
T
I
--------
G
-------
D
T
T
Y
P
L
D
N
P
F
L
V
L
A
T
Q
N
P
V
E
Q
-----
E
--------
G
T
Y
P
L
P
E
A
Q
V
D
--
R
F
M
M
-
K
I
H
L
-
T
Y
L
D
-
K
E
S
-
E
L
E
V
M
R
R
V
S
N
M
--
N
-
F
N
Y
--
Q
V
Q
K
--
I
V
S
K
--
N
D
V
L
E
I
R
-
N
E
----
I
---
N
---
K
V
T
I
S
E
S
L
E
K
Y
I
I
E
L
V
F
A
T
R
---------
F
P
A
EYGL
E
A
E
A
S
Y
-------
I
L
Y
G
A
S
T
R
A
A
I
---
N
L
N
R
V
A
K
A
M
A
F
F
N
-
N
R
------
D
Y
V
L
P
E
D
I
K
E
V
A
Y
D
I
L
N
H
---
R
I
I
L
N
Y
E
A
E
A
E
G
I
S
T
R
Q
I
I
E
T
I
L
-
R
K
V
N
I
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.19
40%
-140
- C1 -
2R44
12
?
A:
[18-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
E
V
I
D
E
V
G
K
V
V
V
G
Q
K
Y
M
I
N
R
L
L
I
G
I
C
---------------
T
----------------
G
-------------
G
--------------
H
-
I
L
L
E
G
V
P
G
L
A
K
T
L
S
V
N
T
L
A
K
-------------------------------
T
M
-
D
L
--
D
F
H
R
I
Q
F
------
T
P
D
L
L
P
S
D
L
I
G
T
M
I
--
Y
N
Q
-
H
K
G
N
F
-------------
E
-
V
--
K
K
G
P
V
-----
F
S
---
N
F
I
L
A
D
E
V
N
R
S
-----------
P
A
K
------------
V
-----------
Q
S
-----
A
L
L
E
C
M
Q
E
--
K
Q
V
T
I
--------
G
-------
D
T
T
Y
P
L
D
N
P
F
L
V
L
A
T
Q
N
P
V
E
Q
-----
E
--------
G
T
Y
P
L
P
E
A
Q
V
D
--
R
F
M
M
-
K
I
H
L
-
T
Y
L
D
-
K
E
S
-
E
L
E
V
M
R
R
V
S
N
M
--
N
-
F
N
Y
--
Q
V
Q
K
--
I
V
S
K
--
N
D
V
L
E
I
R
-
N
E
----
I
---
N
---
K
V
T
I
S
E
S
L
E
K
Y
I
I
E
L
V
F
A
T
R
FPAEYGL
E
A
E
A
S
---------
Y
-------
I
L
Y
G
A
S
T
R
A
A
I
---
N
L
N
R
V
A
K
A
M
A
F
F
N
-
N
R
------
D
Y
V
L
P
E
D
I
K
E
V
A
Y
D
I
L
N
H
---
R
I
I
L
N
Y
E
A
E
A
E
G
I
S
T
R
Q
I
I
E
T
I
L
-
R
K
V
N
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Fugue
64.34
18%
-126
- C1 -
3NBX
2
RAVA_ECOLI
X:
[5-499]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
H
L
L
A
E
R
I
S
R
L
S
S
S
L
E
K
G
L
Y
E
R
S
H
A
I
R
L
C
L
L
A
A
L
---------------
S
----------------
G
-------------
E
--------------
S
-
V
F
L
L
G
P
P
G
I
A
K
S
L
I
A
R
R
L
K
F
-------------------------------
A
-------
F
Q
N
A
R
A
------
F
E
Y
L
M
T
R
F
S
T
P
E
E
V
--
F
G
P
-
L
S
E
R
L
-------------
T
-
S
--
G
Y
L
P
E
------
A
---
E
I
V
F
L
D
E
I
W
K
A
-----------
G
P
A
------------
I
-----------
L
N
-----
T
L
L
T
A
I
N
E
--
R
Q
F
R
N
--------
G
-------
A
H
V
E
K
I
P
M
R
L
L
V
A
A
S
N
E
L
P
E
A
-----
D
--------
S
S
L
---
E
A
L
Y
D
--
R
M
L
I
-
R
L
W
L
-
D
K
V
Q
-
D
K
A
-
N
F
R
S
M
L
T
S
Q
Q
D
--
E
-
N
D
N
--
P
V
P
D
AL
Q
V
T
D
--
E
E
Y
E
R
W
Q
-
K
E
----
I
---
G
---
E
I
T
L
P
D
H
V
F
E
L
I
F
M
L
R
Q
Q
L
D
---------
K
L
P
---------
D
-------
A
-
P
Y
V
S
D
R
R
W
K
---
K
A
I
R
L
L
Q
A
S
A
F
F
S
-
G
R
------
S
A
V
A
P
V
D
L
I
L
L
K
D
C
L
W
Y
D
------
A
Q
S
L
N
L
I
Q
Q
Q
I
D
V
L
M
T
G
H
A
W
-
Q
Q
Q
G
M
L
--
T
R
L
G
A
I
V
QRHLQLQQQQSDKTALTVIRLGGIFSRRQQYQLPVNVTASTLTLLLQKPLKLHDMEVVHISFERSALEQWLSKGGEIRGKLNGIGFAQKLNLEVDSAQHLVVRDVSLQGSTLALPGSLPGEIKQQLEELESDWRKQHALFSEQQKCLFIPGDWLGRIEASLQDVGAQIRQAQQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
60.46
22%
-128
- C1 -
3NBX
1
RAVA_ECOLI
X:
[5-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
H
L
L
A
E
R
I
S
R
L
S
S
S
L
E
K
G
L
Y
E
R
S
H
A
I
R
L
C
L
L
A
A
L
---------------
S
----------------
G
-------------
E
--------------
S
-
V
F
L
L
G
P
P
G
I
A
K
S
L
I
A
R
R
L
K
F
-------------------------------
A
F
-
Q
N
AR
A
F
E
Y
L
-
M
------
T
R
F
S
T
P
E
E
V
F
G
P
L
S
-----------E------------
R
-
L
--
T
S
G
Y
L
P----
E
A
---
E
I
V
F
L
D
E
I
W
K
A
-----------
G
P
A
------------
I
-----------
L
N
-----
T
L
L
T
A
I
N
E
--
R
Q
F
R
N
--------
G
-------
A
H
V
E
K
I
P
M
R
-
L
L
V
A
A
S
N
E
L
P
E
--------------
A
D
-
S
S
L
E
A
L
Y
D
--
R
M
L
I
-
R
L
W
L
-
D
K
V
Q
-
D
K
A
N
F
R
S
M
L
T
S
Q
Q
D
E
--
N
D
N
P
V
--
P
D
A
L
--
Q
V
T
D
--
E
E
Y
E
R
W
Q
-
K
E
----
I
---
G
---
E
I
T
L
P
D
H
V
F
E
L
I
F
M
L
R
Q
Q
L
D
---------
K
L
----------
P
-------
D
A
P
Y
V
S
D
R
R
W
K
---
K
A
I
R
L
L
Q
A
S
A
F
F
S
-
G
R
------
S
A
V
A
P
V
D
L
I
L
L
K
D
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
58.75
21%
-150
- C1 -
3F8T
-
?
A:
[202-485]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
P
L
T
T
F
A
R
A
I
A
P
-
L
P
G
A
E
E
V
G
K
M
L
A
L
Q
L
F
---------------
S
----------------
C
VGKNSE
R
------
L
--------------
H
-
V
L
L
A
G
Y
P
V
V
C
S
E
I
L
H
H
V
L
D
H
-------------------------------
L
A
-
P
R
--
G
V
Y
V
-
D
L
-------
R
R
T
E
L
T
D
L
T
A
V
L
K
--
E
D
----
R
G
W
-------------
A
-
L
--
R
A
G
A
A
V
L
A
--
D
G
---
G
I
L
A
V
D
H
L
E
G
A
-----------
P
E
P
------------
H
-----------
R
W
-----
A
L
M
E
A
M
D
K
--
G
T
V
T
V
--------
D
-------
G
I
--
A
L
N
A
R
C
A
V
L
A
A
I
N
P
G
E
-PSDPP
I
--------
A
R
I
D
L
D
Q
D
F
L
S
--
H
F
D
L
-
I
A
F
L
G-----------------------------------
V
P
S
Y
--
T
L
L
R
R
Y
L
-
L
Y
A
I
R
E
H
---
P
---
A
P
E
L
T
E
E
A
R
K
R
L
E
H
W
Y
E
T
R
R
---------
E
E
V
---------
E
E
R
L
G
M
G
L
P
T
L
P
V
T
R
R
Q
L
E
---
S
V
E
R
L
A
K
A
H
A
R
M
R
-
L
S
------
D
D
V
E
P
E
D
V
D
I
A
A
E
L
V
D
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Fugue
51.95
19%
-105
- C1 -
1G8P
-
BCHI_RHOCB
A:
[18-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
V
F
P
F
S
A
I
V
G
Q
E
D
M
K
L
A
L
L
L
T
A
V
D
---------------
P
----------------
G
I------------
G
--------------
G
-
V
L
V
F
G
D
R
G
T
G
K
S
T
A
V
R
A
L
A
A
L
L
P
E
I
E
A
VEGCPVSSPNVEMIPDWATVLST
N
V
I
-
R
K
--
P
T
P
V
V
D
L
------
P
L
G
V
S
E
D
R
V
V
G
A
L
D
--
I
E
R
-
A
I
S
K
G
-------------
E
-
K
A
F
E
P
G
L
L
-----
A
R
A
NR
G
Y
L
Y
I
D
E
C
N
L
L
-----------
E
D
H
------------
I
-----------
V
D
-----
L
L
L
D
V
A
Q
S
--
G
E
N
V
V
--------
E
RD-----
G
L
S
I
R
H
P
A
R
F
V
L
V
G
S
G
N
P
E
E
G
-----
D
------------
L
R
P
Q
L
L
D
--
R
F
G
L
-
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E
V
-
L
S
P
R
D
V
E
T
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R
V
E
V
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R
R
R
D
T
Y
--
D
-
A
D
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--
K
A
F
L
--
E
E
W
R
--
P
K
D
M
D
I
R
-
N
Q
----
I
---
L
---
E
A
R
E
R
L
P
K
V
E
A
P
N
T
A
L
Y
D
C
A
---------
A
L
C
---------
I
-------
A
L
G
S
D
G
L
R
G
E
L
---
T
L
L
R
S
A
R
A
L
A
A
L
E
-
G
A
------
T
A
V
G
R
D
H
L
K
R
V
A
T
M
A
L
S
H
---
R
L
R
V
A
R
T
V
E
E
T
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
51.68
20%
-108
- C1 -
4R7Y
3
MCM_SULSO
A:
[292-605]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
D
A
I
V
D
S
I
A
P
A
I
Y
G
Y
K
E
V
K
K
G
I
A
L
A
L
F
---------------
G
----------------
G
-------------
V
SRKLPDGTRLRG
D
I
H
-
V
L
L
V
G
D
P
G
V
A
K
S
Q
I
L
R
Y
V
A
N
-------------------------------
L
A
-
P
R
--
A
I
Y
T
S
G
K
--------
S
S
S
A
A
G
L
T
A
A
A
V
--
R
D
E
-
F
T
G
G
W
-------------
V
-
L
--
E
A
G
A
L
V
L
A
--
D
G
---
G
Y
A
L
I
D
E
L
D
K
M
-----------
S
D
R
------------
D
-----------
R
S
-----
V
I
H
E
A
L
E
Q
--
Q
T
I
S
I
S
K
------
A
-------
G
I
T
A
T
L
N
A
R
T
T
V
I
A
A
A
N
P
K
Q
G
-----
R
FNRMKNPF
E
Q
I
D
L
P
P
T
L
L
S
--
R
F
D
L
I
F
V
L
I
-
D
E
P
D
-
D
K
I
-
D
S
E
V
A
R
H
I
L
R
V
--
R
-
R
G
E
SE
V
V
A
P
--
K
I
P
H
--
E
I
L
R
K
Y
I
-
A
Y
----
A
---
R
K
N
I
H
P
V
I
S
E
E
A
M
E
E
I
E
K
Y
Y
V
R
M
R
---------
K
S
---------------------
P
I
T
A
R
Q
L
E
---
A
L
I
R
L
S
E
A
H
A
R
M
R
-
L
S
------
P
I
V
T
R
E
D
A
R
E
A
I
K
L
M
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
45.10
25%
-112
- C1 -
1SXJ
3
RFC2_YEAST
D:
[60-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
M
L
F
Y
G
P
P
G
T
G
K
T
S
T
I
L
A
L
T
K
-------------------------------
E
L
Y
G
P
--
D
L
M
K
S
R
I
------
L
-
E
L
N
A
S
D
E
R
G
I
S
I
--
V
R
E
-
K
V
K
N
F
A
R
L
T
V
S
K
P
S
K
H
D
L
E
-
N
--
Y
P
C
P
P
-----
Y
----
K
I
I
I
L
D
E
A
D
S
M
-----------
T
A
D
------------
A
-----------
Q
S
-----
A
L
R
R
T
M
E
------
T
Y
--------
S
-------
G
V
T
R
F
C
L
I
C
N
Y
V
T
R
I
I
D
P
L
----------------------
A
S
Q
C
S
--
K
F
R
F
-
K
-------------
A
L
D
A
------
S
--
N
-
A
I
D
--
R
L
R
-----------
F
I
----
S
E
----
Q
---
E
---
N
V
K
C
D
D
G
V
L
E
R
I
L
D
I
-----------------------------------
S
A
G
D
L
R
R
G
I
T
---
L
L
Q
S
A
S
K
G
A
Q
Y
L
G
-
D
G
------
K
N
I
T
S
T
Q
V
E
E
L
A
G
-
V
V
P
H
---
D
I
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
HHSearch
44.93
23%
-145
- C1 -
4LCB
1
?
A:
[98-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
D
I
V
G
L
D
D
V
K
E
A
L
K
E
A
I
I
Y
P
S
K
RPDLFPLG---
W
----------------
P
-------------
R
--------------
G
-
I
L
L
Y
G
P
P
G
N
G
K
T
M
L
A
A
A
V
A
N
-------------------------------
E
I
-
D
S
--
Y
F
I
H
V
D
A
------
A
S
I
M
S
K
----
G
E
A
E
K
N
V
A
K
-
I
F
N
T
A
R
------------
E
-
Y
--
S
K
K
D
N
-----
K
P
---
A
I
I
F
V
D
E
I
D
A
L
-----------
L
---------------V
R
V
--------
R
N
-----
Q
F
L
K
E
M
D
G
--
I
M
---------------------------
M
V
Y
V
I
G
A
T
N
K
P
W
------------------
R
L
D
E
P
F
L
R
--
R
F
Q
K
-
R
I
Y
V
-
P
L
P
D
-
F
N
Q
-
R
L
A
L
F
K
Y
Y
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
44.57
21%
-122
- C1 -
5C3C
1
?
A:
[26-211]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
P
Y
Y
R
A
V
Q
D
E
I
E
L
Y
R
A
G
Y
E
---------------
A
----------------
R
-------------
I
--------------
P
-
M
M
L
K
G
P
T
G
C
G
K
S
R
F
V
E
H
M
A
W
-------------------------------
K
L
-
N
R
--
P
L
I
T
I
A
C
------
N
E
D
M
T
A
S
D
L
V
G
R
--------------------------------
D
G
P
L
T
V
A
A
R
I
G
---
A
I
C
Y
L
D
E
I
V
E
A
-----------
R
Q
D
------------
T
-----------
I
V
-----
V
I
H
P
L
T
D
H
--
R
R
V
L
P
LEK-----
K
-------
G
E
L
V
E
A
H
P
D
F
Q
I
V
I
S
Y
N
P
--------------------
D
L
K
Q
S
T
K
Q
--
R
F
G
A
--
L
D
F
-
D
Y
P
K
-
P
D
I
-
E
A
E
I
V
S
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
43.82
18%
-82
- C1 -
4FDG
-
MCM_SULSO
B:
[295-600]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
I
R
D
R
I
I
S
S
I
A
P
S
I
Y
G
H
W
E
L
K
E
A
L
A
L
A
L
F
---------------
G
----------------
G
VPKVLEDTRIRGD
I
--------------
H
-
I
L
I
I
G
D
P
G
T
A
K
S
Q
M
L
Q
F
I
S
R
-------------------------------
V
A
-
P
R
--
A
V
Y
T
T
G
K
------
G
S
--
T
A
A
G
L
T
A
A
V
V
--
R
E
K
-
G
T
G
E
Y
-------------
Y
-
L
--
E
A
G
A
L
VLA--
D
G
---
G
I
A
V
I
D
E
I
D
K
M
-----------
R
D
E
------------
D
-----------
R
V
-----
A
I
H
E
A
M
E
Q
--
Q
T
V
S
I
AK------
A
-------
G
I
V
A
K
L
N
A
R
A
A
V
I
A
A
G
N
P
K
F
G
-----
R
YISERPVS
D
N
I
N
L
P
P
T
I
L
S
--
R
F
D
L
-
I
F
I
L
-
K
D
Q
P
-
G
E
Q
-
D
R
E
L
A
N
Y
I
L
D
V
--
H
-
S
G
K
--
S
T
K
N
--
I
I
D
I
--
D
T
L
R
K
Y
I
-
A
Y
----
A
RKY
V
---
T
P
K
I
T
S
E
A
K
N
L
I
T
D
F
F
V
E
M
R
---------
K
K
S
SETP-----
D
-------
S
P
I
L
I
T
P
R
Q
L
E
---
A
L
I
R
I
S
E
A
Y
A
K
M
A
-
L
K
------
A
E
V
T
R
E
D
A
E
R
A
I
N
I
M
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Fugue
42.72
19%
-102
- C1 -
1HQC
2
RUVB_THET8
A:
[5-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
R
P
K
T
L
D
E
Y
I
G
Q
--
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
R
K
E
P
L
-----------------------------------------------
E
--------------
H
-
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
-------------------------------
E
L
-
G
V
--
N
L
R
V
T
S
-----------------
G
P
A
I
--
E
K
P
-
G
D
L
A
A
-------------
I
-
L
--
A
N
S
L
E
-----
E
G
---
D
I
L
F
I
D
E
I
H
R
L
-----------
S
R
Q
------------
A
-----------
E
E
-----
H
L
Y
P
A
M
E
D
--
F
V
M
D
I
VIGQGPA
A
R
-------
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
P
G
L
I
---------------
T
A
P
L
L
----
S
--
R
F
G
I
-
V
E
H
L
-
E
Y
Y
T
-
P
E
E
-
L
A
Q
G
V
M
R
D
A
R
L
--
L
-
G
V
R
---------
I
T
E
--
E
A
A
L
E
I
G
-
R
R
----
S
---
R
---
G
------
T
M
R
V
A
K
R
L
F
R
R
V
R
---------
D
F
A
---------
Q
-------
V
A
----
G
E
E
V
I
---
T
R
E
R
A
L
E
A
L
A
A
L
G
L
D
E
------
L
G
L
E
K
R
D
R
E
I
L
E
V
L
I
L
R
F
GGG
P
V
G
L
A
T
L
A
T
A
L
S
E
D
P
G
T
L
E
E
V
H
E
-
P
Y
L
I
R
Q
GL
L
K
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
GYPPPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
41.61
18%
-110
- C1 -
1HQC
2
RUVB_THET8
A:
[9-238]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
D
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
---------------
A
A
K
A
R
KEP---------
L
-------------
E
--------------
H
-
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
-------------------------------
E
L
-
G
V
--
N
L
R
V
T
S
G
------
P
A
I
E
K
P
G
D
L
A
A
I
L
A
---------
N
--------------
S
-
L
--
E
---------
E
G
---
D
I
L
F
I
D
E
I
H
R
L
-----------
S
R
Q
------------
A
-----------
E
E
-----
H
L
Y
P
A
M
E
D
--
F
V
M
D
I
--------
V
IGQGPA
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
P
G
------------------
L
I
T
A
P
L
L
S
--
R
F
G
I
-
V
E
H
L
-
E
Y
Y
T
-
P
E
E
-
L
A
Q
G
V
M
R
D
A
--------------------------------
R
----
L
---
L
---
G
V
R
I
T
E
E
A
A
L
E
I
G
R
R
S
R
G
------------------------------------
T
M
R
V
A
K
---
R
L
F
R
R
V
R
D
F
A
Q
V
A
-
G
E
------
E
V
I
T
R
E
R
A
L
E
A
L
A
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
41.17
20%
-94
- C1 -
3H4M
1
PAN_METJA
A:
[15-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
----------------
P
-------------
K
--------------
G
-
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
-------------------------------
E
T
-
N
A
--
T
F
I
R
V
V
G
------
S
E
L
V
K
K
--
F
I
G
E
G
A
--
S
-
L
--
V
K
D
I
-------------
F
-
K
--
L
A
K
E
K
-----
A
P
---
S
I
I
F
I
D
E
I
D
A
I
AAKRTDALTGG
D
R
E
------------
V
-----------
Q
R
-----
T
L
M
Q
L
L
A
E
--
M
D
G
---------------------
F
D
A
R
G
D
V
K
I
I
G
A
T
N
R
P
D
------------------
I
L
D
P
A
I
L
R
PG
R
F
D
R
-
I
I
E
V
-
P
A
P
D
-
E
K
G
-
R
L
E
I
L
K
I
H
T
R
K
---------------------------------------
M
---
N
L
-
A
E
D
V
N
L
E
E
I
A
K
M
T
-----------------------------------
E
G
C
V
G
A
E
L
K
---
A
I
C
T
E
A
G
M
N
A
I
R
E
-
L
R
------
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
---
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Fugue
40.21
20%
-106
- C1 -
3VKG
7
?
A:
[47-3244]
E
I
D
S
L
K
E
TAWSAIIPA
F
D
H
A
Q
N
L
I
K
I
Y
L
K
G
N
A
I
I
T
D
L
H
SEAIK
D
R
H
W
K
I
L
K
K
R
L
NTNWIITELT
L
G
S
I
W
D
S
DLARN
E
N
I
Y
R
E
V
I
T
A
A
Q
G
E
I
A
L
E
E
F
L
K
G
V
R
E
F
W
T
TLELD
L
V
N
Y
QRK
C
K
L
V
R
G
W
D
D
L
F
N
K
L
A
E
H
L
N
S
I
S
A
M
KMSPYYKVF
E
E
E
A
N
H
W
D
D
R
L
N
K
V
R
S
L
L
D
V
W
I
D
V
Q
R
R
W
V
Y
LEGIFINQLL
P
A
E
S
T
R
F
K
S
I
N
S
E
F
I
A
I
L
K
K
V
S
G
A
PL
I
L
E
V
L
A
IER
I
Q
Q
T
M
E
R
L
S
D
L
L
G
K
V
Q
K
A
L
G
E
Y
L
E
R
Q
R
S
A
F
A
R
F
Y
F
V
G
D
E
D
L
L
E
I
I
G
N
S
KDIIKIQKHFRKMFAGLA
N
L
T
L
D
DEKTTII
G
M
S
S
AEG
E
T
V
T
F
K
K
P
I
S
IANGPK
I
H
E
W
L
T
M
V
E
S
E
M
K
S
T
L
A
T
L
L
S
E
S
L
Q
H
F
N
Q
VDVNDHS
K
Y
S
E
W
V
D
N
Y
P
T
Q
L
V
L
L
T
S
Q
I
V
W
S
T
Q
V
D
Q
A
L
GGGTLQ
Q
S
K
I
Q
E
Q
L
Q
S
I
E
Q
T
T
Q
M
I
L
N
N
L
A
D
S
VLQDLS
A
Q
K
R
K
K
F
E
H
L
I
T
E
L
V
H
Q
R
D
V
V
R
Q
L
Q
K
CKNLTGNKDF
D
W
L
Y
H
M
R
Y
Y
Y
D
ATQENVLHK
L
V
I
H
M
AN
A
T
F
Y
YGFEYLGIGERLVQT
P
L
T
D
R
C
Y
L
T
L
T
Q
A
L
E
S
R
M
G
G
N
P
F
G
P
A
GTG
K
T
E
T
V
K
A
L
G
S
Q
L
G
R
F
V
L
V
F
C
CDEGFD
L
Q
A
M
S
R
I
F
V
G
L
C
Q
C
G
A
W
G
C
F
D
EFNRLE
E
R
I
L
S
A
V
S
Q
Q
I
Q
T
I
Q
V
A
L
K
E
NSKEVELLN
I
S
L
H
QD
M
G
I
F
V
T
M
N
P
GYAGRSNLPDNLKKL
F
R
S
M
A
M
IKPD
R
E
M
I
A
Q
V
M
L
Y
S
Q
GFKT
A
E
V
L
A
G
K
I
V
P
L
F
K
L
C
Q
E
QLSAQSHYDFG
L
R
A
L
K
S
V
L
V
S
A
G
G
I
K
R
K
CQPPD
A
E
S
K
T
K
A
D
Q
I
Y
C
Q
Y
E
I
G
V
L
L
N
S
I
N
D
TMIPKLVADD
I
P
L
I
Q
S
L
L
L
D
V
F
PG
S
Q
L
Q
P
I
QM
D
Q
L
R
K
K
I
Q
E
I
A
K
Q
R
HLVTK
Q
E
W
V
E
K
I
L
Q
L
H
Q
I
L
N
I
NH
G
V
M
M
V
G
P
S
GGG
K
T
T
S
W
E
V
Y
L
E
A
I
E
Q
V
DN
I
K
S
E
A
H
V
M
DPKAITKDQLF
G
S
L
D
LTTR
E
W
T
D
G
L
F
T
A
T
L
R
R
I
I
D
NVRGEST
K
R
H
W
I
I
F
D
G
D
V
D
PEWVENLNSLLDDNK
L
L
T
L
PNGE
R
L
A
L
P
NN
V
R
V
M
F
E
V
QDLKYATLATISR
C
G
M
V
W
F
S
EEILT
T
Q
M
I
F
Q
N
Y
L
D
T
L
S
N
E
PFD
P
Q
E
K
E
Q
Q
K
R
N
E
N
AIP
A
G
L
K
V
Q
K
E
C
A
A
I
I
SQYFEPGG
L
V
H
K
V
L
E
D
A
G
Q
RPHIMDFT
R
L
R
V
L
N
S
F
F
S
L
M
N
R
S
I
V
N
V
I
E
Y
N
Q
L
HSDFPMS
P
E
N
Q
S
N
Y
I
T
N
R
L
L
Y
S
L
M
W
GLGGSMG
L
V
E
R
E
N
F
S
K
F
I
Q
T
I
AITPVPANTIPLLD
Y
S
V
S
IDDA
N
W
S
L
W
K
N
K
V
E
V
E
T
H
K
V
A
S
P
D
V
V
I
P
T
V
D
T
T
R
H
V
D
V
L
H
A
W
L
---------------
S
----------------
E
-------------
H
--------------
R
P
L
I
L
C
G
P
P
G
S
G
K
T
M
T
L
T
S
T
L
R
-------------------------------
A
F
--
P
--
D
F
E
V
V
S
L
N
F
S
SAT
T
P
E
L
L
L
K
T
F
D
H
H
C
E
--
Y
K
R
T
P
S
G
E
T
-------------
V
-
L
--
R
P
T
Q
L
G----
K
W
---
L
V
V
F
C
D
E
I
N
L
P
-----------
S
T
D
------------
K
-----------
Y
G
TQ
R
V
I
T
F
I
R
Q
M
V
E
KG
G
F
W
R
T
--------
S
-------
D
H
T
W
I
K
L
D
K
I
Q
F
V
G
A
C
N
P
P
T
D
-----
A
--------
G
R
V
Q
L
T
H
R
F
L
R
--
H
A
P
I
-
L
L
-
V
-
D
F
P
S
-
T
S
S
-
L
T
Q
I
Y
G
T
F
N
R
A
L
M
K
-
L
L
P
--
N
L
R
S
--
F
A
D
N
L
T
D
A
M
V
E
F
Y
-
S
E
----
S
---
Q
---
K
R
F
T
P
D
I
Q
A
H
Y
I
Y
S
P
R
E
L
S
R
---------
W
D
R
---------
A
-------
L
L
E
A
I
Q
T
M
D
G
C
T
L
E
G
L
V
R
L
W
A
H
E
A
L
R
L
-
F
Q
------
D
R
L
V
E
T
E
E
K
E
W
T
D
K
K
I
D
E
---
V
A
L
K
H
----
F
P
S
V
N
L
D
A
L
K
R
P
I
L
Y
S
N
W
L
T
P
--
V
N
R
S
D
L
R
E
Y
V
K
A
R
L
K
V
F
YPLVLF
N
E
V
L
D
H
I
L
R
I
D
R
V
F
R
Q
PQG
H
A
L
L
I
G
V
SGGG
K
S
V
L
S
R
F
V
A
W
M
N
G
L
S
I
Y
T
I
KYK
S
S
D
F
D
D
D
L
R
M
L
L
K
R
A
GCKE
E
K
I
C
F
I
F
D
ESNVLE
S
S
F
L
E
R
M
N
T
L
L
A
GGEVPGLFE
G
E
E
F
T
A
L
M
H
A
C
K
E
T
A
Q
R
N
GLILDS
E
E
E
L
Y
K
Y
F
T
S
Q
V
R
R
N
L
H
V
V
F
T
M
N
PASPDFHNS
P
A
L
F
N
R
C
VLDWFGEWS
P
E
A
L
F
Q
V
G
S
E
F
T
RNLDLENPQ
Y
I
A
P
P
V
F
I
Q
E
A
EILMAIPPS
H
R
D
A
V
V
S
S
L
V
Y
I
H
Q
T
I
G
E
A
N
I
R
L
L
K
R
QG
R
Q
N
Y
V
T
P
R
H
Y
L
D
F
I
N
Q
V
V
L
L
I
N
E
K
R
D
Q
L
E
E
E
Q
L
H
L
N
I
G
L
K
K
L
R
D
T
E
A
Q
V
K
D
L
Q
V
S
L
A
Q
K
N
R
E
L
D
V
K
N
E
Q
A
N
Q
K
L
K
Q
M
V
Q
D
Q
Q
A
A
E
I
K
Q
K
D
A
R
E
L
Q
V
Q
L
D
V
R
N
K
E
I
A
V
Q
K
V
K
A
Y
A
D
LP
L
R
E
E
V
E
Q
L
E
N
A
A
N
E
L
K
L
K
Q
D
E
I
V
A
T
I
T
A
L
E
K
S
I
A
T
Y
K
E
E
Y
A
T
L
I
R
E
T
E
Q
I
K
T
E
S
S
K
V
K
N
K
V
D
R
S
I
A
L
L
D
N
L
N
S
E
R
G
R
W
E
Q
Q
S
E
N
F
N
T
Q
M
S
T
V
V
G
D
V
V
L
A
S
A
F
L
A
YIGFFD
Q
N
F
R
T
D
L
M
R
K
W
M
I
R
L
D
S
V
GIKFKSDLS
V
P
S
F
L
SK
P
E
E
R
L
N
W
H
A
N
SLPSD
E
L
C
I
E
N
A
I
M
L
K
RFNRYPLVIDPSG
Q
A
M
E
F
L
M
N
Q
Y
A
DKKITKTSF
M
K
N
L
E
S
A
L
R
F
G
C
P
L
L
V
Q
DVES
F
M
I
F
L
F
T
RDPT
A
H
F
T
P
D
L
C
S
R
V
T
F
V
N
FTVT
P
S
S
L
Q
S
Q
C
L
H
E
A
L
K
T
ERP
D
T
H
K
K
R
S
DLLKIQGEFQVKLR
I
L
E
K
S
L
L
N
A
L
S
Q
A
SGNILDD
D
S
V
I
S
T
L
E
T
L
K
K
E
TT
E
I
A
L
K
V
E
E
T
E
T
V
M
Q
E
I
S
E
V
S
A
L
Y
N
P
M
A
L
S
C
S
R
V
Y
F
A
M
E
E
L
SQFHL
Y
Q
F
S
L
R
A
F
L
D
I
F
Y
N
L
L
NNNPNLVDKKD
P
N
E
R
L
V
Y
L
S
K
D
I
F
S
M
T
F
N
R
V
T
R
T
LLNDD
K
L
T
F
A
L
Q
L
T
I
I
S
V
KGTSNEIE
E
S
E
W
D
F
L
L
KGGDNLTSIKETIPQLDSLLS
T
T
Q
Q
K
W
L
I
C
L
R
Q
QVPSFSK
L
V
D
H
I
Q
Q
N
SSDWKQFFGKDQVGEPIIP
E
S
W
I
V
A
Q
A
Q
L
S
NQQS
T
I
V
S
N
F
R
K
I
L
L
M
K
A
FHSDR
V
L
Q
Y
S
H
S
F
V
C
S
V
FGEDFLNTLD
M
A
N
I
V
E
KEVKSS
S
P
L
L
LCSVPGYDA
S
S
K
V
D
D
L
A
L
Q
L
H
K
Q
Y
K
S
F
A
I
GSPEGFELAEK
S
I
Y
A
A
A
K
SG
T
W
V
L
L
K
NIHLAPQWL
V
Q
L
E
K
K
L
H
S
L
S
P
H
PS
F
R
L
F
M
T
S
E
IHPALP
A
N
L
L
R
M
S
N
V
F
S
Y
E
NPPG
V
K
A
N
L
L
H
T
F
I
G
IP
A
T
R
M
D
KQPAE
R
S
R
I
Y
F
L
L
A
W
F
H
A
I
I
Q
E
R
L
RYIPLGWTKFFEFN
D
A
D
L
R
G
A
L
D
S
I
D
Y
W
V
D
L
Y
SKGRSNIDPDKIP
W
I
A
V
R
T
I
L
G
STIYGGRIDN
E
F
D
M
R
L
L
Y
S
F
L
E
Q
L
F
TPSAFNPDFPLVPSIGL
S
V
P
E
G
TT
R
A
H
F
M
K
W
I
E
A
LPEISTPIWLGLPEN
A
E
S
L
L
L
S
N
K
A
R
K
M
I
N
D
L
Q
K
M
Q
S
S
E
E
DS
S
S
S
E
D
K
G
K
A
KP
L
F
R
C
F
E
R
E
I
S
T
G
G
K
L
V
K
K
I
T
N
D
L
A
N
L
LKW
Y
S
V
P
ETIS
L
S
V
W
I
S
D
F
S
K
R
M
Q
Q
L
S
E
I
S
E
SVWLGGLLN
P
E
A
Y
I
T
A
T
R
Q
S
A
S
Q
L
NGRLHASA
S
F
N
V
K
G
M
A
L
E
G
A
V
W
N
ND
Q
L
T
P
TDIL
S
T
P
I
S
I
A
T
L
T
W
K
DPIFNNSSS
K
L
S
V
P
V
Y
LNETRSELL
F
S
I
D
L
P
Y
DQSTS
K
Q
N
W
Y
Q
R
S
V
S
I
S
SWKSD
64
HHSearch
40.16
18%
-97
- C1 -
1OFH
4
HSLU_HAEIN
A:
[7-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
I
V
S
E
L
D
Q
H
I
I
G
Q
A
D
A
K
R
A
V
A
I
A
L
R
---------------
N
R
W
R
R
M
Q
LQEPLRHEVT
P
-------------
K
--------------
N
-
I
L
M
I
G
P
T
G
V
G
K
T
E
I
A
R
R
L
A
K
-------------------------------
L
A
-
N
A
--
P
F
I
K
V
E
A
------
T
K
F
T
E
V
G
Y
V
G
K
E
V
D
S
I
I
R
D
-
L
T
D
S
A
-------------
G
G
A
--
I
D
A
V
E
-----
Q
N
---
G
I
V
F
I
D
E
I
D
K
I
-----------
C
K
K
GEYSGA
D
V
S
R
E
G
V
-----------
Q
R
-----
D
L
L
P
L
V
E
G
--
S
T
V
S
T
--------
K
-------
H
G
M
V
-
K
T
D
H
I
L
F
I
A
S
G
A
F
Q
V
------
A
--------
R
P
S
D
L
I
P
E
L
Q
G
--
R
L
P
I
-
R
V
E
L
-
T
A
L
S
-
A
A
D
-
F
E
R
I
L
T
E
P
H
A
S
--
L
---------------
T
--
E
Q
Y
K
A
L
M
A
T
E
----
G
---
V
---
N
I
A
F
T
T
D
A
V
K
K
I
A
E
A
A
F
R
V
N
---------
E
-------------------
K
T
E
N
I
G
A
R
R
L
H
---
T
V
M
E
R
L
M
D
K
I
S
F
S
-
A
S
DMNG
Q
T
V
N
I
D
A
A
Y
V
A
D
A
L
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
39.30
21%
-89
- C1 -
4CR2
-
PRS4_YEAST
I:
[181-427]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
D
I
G
G
L
E
S
Q
I
Q
E
I
K
E
S
V
E
L
P
L
T
H
P
E
L
Y
E
E
M
GIK
P
----------------
P
-------------
K
--------------
G
-
V
I
L
Y
G
A
P
G
T
G
K
T
L
L
A
K
A
V
A
N
-------------------------------
Q
T
-
S
A
--
T
F
L
R
I
V
G
------
S
E
L
I
Q
K
--
Y
L
G
D
G
P
---
R
L
-
C
R
Q
I
F
-------------
K
----
V
A
G
E
N
-----
A
P
---
S
I
V
F
I
D
E
I
D
A
I
-----------
G
T
K
------------
R
YDSNSGGE
R
E
I
Q
R
-----
T
M
L
E
L
L
N
Q
--
L
D
G
---------------------
F
D
D
R
G
D
V
K
V
I
M
A
T
N
K
I
E
------------------
T
L
D
P
A
L
I
R
PG
R
I
D
R
-
K
I
L
F
-
E
N
P
D
-
L
S
T
-
K
K
K
I
L
G
I
H
T
S
K
---------------------------------------
M
---
N
L
S
-
E
D
V
N
L
E
T
L
V
T
T
-----------------------------------
K
D
D
L
S
G
A
D
I
Q
---
A
M
C
T
E
A
G
L
L
A
L
R
E
-
R
R
------
M
Q
V
T
A
E
D
F
K
Q
A
K
E
R
V
M
K
N
---
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
39.14
48%
-176
- C1 -
3WHK
1
PAN_PYRFU (first)
D:
[54-97]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
A
I
A
H
-------------------------------
E
V
-
N
A
--
T
F
I
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
39.06
48%
-177
- C1 -
3WHK
1
PAN_PYRFU (first)
C:
[54-98]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
A
I
A
H
-------------------------------
E
V
-
N
A
--
T
F
I
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
39.00
48%
-176
- C1 -
3WHK
1
PAN_PYRFU (first)
E:
[54-97]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
A
I
A
H
-------------------------------
E
V
-
N
A
--
T
F
I
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------