@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06500: (2016-06-10 )
MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGMFDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGVAEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLGEELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIPPIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKKGEGVTFGGAALS
Atome Classification :
(20 SA)
.........10........20........30....-....--40........--50-.........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210--...-.....220.......230.......-240.......250.......260.......270.......280.......290.......300.......310.......320-.......330.......340.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
E
A
Y
KNAGVD
I
E
A
G
Y
E
A
V
K
R
M
K
K
H
V
E
R
T
K
R
LGVM-GSLG--GFGGMF
D
L
S
E--L--SYQK
P
V
L
I
SGTDGVG
T
K
L
K
L
A
F
SMDKHDTI
G
V
D
A
V
A
M
C
V
N
D
V
L
A
QGAE
P
L
F
F
L
D
Y
L
AVGKAD
P
V
K
I
E
Q
I
V
Q
G
V
A
E
G
C
E
QSG
S
A
L
VGGETAEMPGLYTADEYDIAGFSVGVAEKDEIVTGEKIEEG
H
L
L
I
G
LSSSGLHSN
G
F
S
L
V
R
K
V
LLDDAELDLDTT
Y
-
E
--
P
F
E
-
R
P
L
G
E
E
L
LE
P
T
R
I
Y
V
K
P
V
L
A
A
V
KSG-KID
G
M
A
H
VTGG
G
F
I
E
N
I
P
R
MLPEGLSAEIDHGSWPI
P
P
I
F
S
F
L
Q
E
Y
GKL
K
E
E
D
M
F
N
V
F
N
MGI
G
F
V
L
A
V
K
E
E
H
L
T
D
V
I
G
T
L
E
SH-G
E
K
A
Y
L
I
G
R
VKKGE
G
V
T
F-GGAALS
2
PsiBlast_PDB
92.64
64%
-124
- C3 -
2Z01
-
PUR5_GEOKA
A:
[17-342]
----------------
Q
A
V
A
L
M
K
E
H
V
Q
K
T
M
R
P
E
V
L
-
G
-------
G
G
L
F
D
L
S
A
--
L
--
G
Y
R
Q
P
V
L
I
S
G
T
D
G
V
G
T
K
L
K
L
A
F
L
L
D
R
H
D
T
I
G
I
D
C
V
A
M
C
V
N
D
I
I
V
Q
G
A
E
P
L
F
F
L
D
Y
I
A
C
G
K
A
V
P
E
K
I
A
A
I
V
K
G
V
A
D
G
C
V
E
A
G
C
A
L
I
G
G
E
T
A
E
--------
E
Y
D
L
A
G
F
A
V
G
V
A
E
K
E
R
L
I
T
G
E
T
I
Q
A
G
D
A
L
V
G
L
P
S
S
G
L
H
S
N
G
Y
S
L
V
R
R
I
V
F
E
Q
A
K
L
S
L
D
E
I
Y
-
E
--
P
L
D
-
V
P
L
G
E
E
L
L
K
P
T
R
I
Y
A
K
L
L
R
S
V
R
E
R
F
-
T
I
K
G
M
A
H
I
T
G
G
G
L
I
E
N
I
P
R
M
L
P
P
G
I
G
A
R
I
Q
L
G
S
W
P
I
L
P
I
F
D
F
L
R
E
K
G
S
L
E
E
E
E
M
F
S
V
F
N
M
G
I
G
L
V
L
A
V
S
P
E
T
A
A
P
L
V
E
W
L
S
E
R
-
G
E
P
A
Y
I
I
G
E
V
A
K
G
A
G
V
S
F
-
A
G
----
38
HHSearch
92.17
64%
-127
- C3 -
2Z01
-
PUR5_GEOKA
A:
[17-340]
----------------
Q
A
V
A
L
M
K
E
H
V
Q
K
T
M
R
P
E
V
L
-
G
-------
G
G
L
F
D
L
S
A
--
L
--
G
Y
R
Q
P
V
L
I
S
G
T
D
G
V
G
T
K
L
K
L
A
F
L
L
D
R
H
D
T
I
G
I
D
C
V
A
M
C
V
N
D
I
I
V
Q
G
A
E
P
L
F
F
L
D
Y
I
A
C
G
K
A
V
P
E
K
I
A
A
I
V
K
G
V
A
D
G
C
V
E
A
G
C
A
L
I
G
G
E
T
A
E
--------
E
Y
D
L
A
G
F
A
V
G
V
A
E
K
E
R
L
I
T
G
E
T
I
Q
A
G
D
A
L
V
G
L
P
S
S
G
L
H
S
N
G
Y
S
L
V
R
R
I
V
F
E
Q
A
K
L
S
L
D
E
I
Y
E
P
--
L
D
--
V
P
L
G
E
E
L
L
K
P
T
R
I
Y
A
K
L
L
R
S
V
R
E
R
F
-
T
I
K
G
M
A
H
I
T
G
G
G
L
I
E
N
I
P
R
M
L
P
P
G
I
G
A
R
I
Q
L
G
S
W
P
I
L
P
I
F
D
F
L
R
E
K
G
S
L
E
E
E
E
M
F
S
V
F
N
M
G
I
G
L
V
L
A
V
S
P
E
T
A
A
P
L
V
E
W
L
S
E
R
-
G
E
P
A
Y
I
I
G
E
V
A
K
G
A
G
V
S
F
-------
1
PsiBlast_PDB
92.11
69%
-115
- C3 -
2BTU
-
PUR5_BACAN
A:
[13-341]
------------
E
A
G
Y
E
A
V
S
R
M
K
K
H
V
Q
T
T
M
R
K
E
V
L
-
G
-----
G
F
G
G
M
F
D
L
S
K
--
F
--
A
L
E
E
P
V
L
V
S
G
T
D
G
V
G
T
K
L
M
L
A
F
M
A
D
K
H
D
T
I
G
I
D
A
V
A
M
C
V
N
D
I
V
V
Q
G
A
E
P
L
F
F
L
D
Y
I
A
C
G
K
A
E
P
S
K
I
E
N
I
V
K
G
I
S
E
G
C
R
Q
A
G
C
A
L
I
G
G
E
T
A
E
M
P
G
M
Y
S
T
E
E
Y
D
L
A
G
F
T
V
G
I
V
D
K
K
K
I
V
T
G
E
K
I
E
A
G
H
V
L
I
G
L
A
S
S
G
I
H
S
N
G
Y
S
L
V
R
K
V
L
L
E
D
G
E
L
----
I
Y
-
G
--
R
L
E
-
L
P
L
G
E
E
L
L
K
P
T
K
I
Y
V
K
P
I
L
E
L
L
K
N
H
-
E
V
Y
G
M
A
H
I
T
G
G
G
F
I
E
N
I
P
R
M
L
P
E
G
I
G
A
E
I
E
L
G
S
W
K
I
Q
P
I
F
S
L
L
Q
E
V
G
K
L
E
E
K
E
M
F
N
I
F
N
M
G
I
G
M
V
V
A
V
K
E
E
D
A
K
D
I
V
R
L
L
E
E
Q
-
G
E
T
A
R
I
I
G
R
T
V
Q
G
A
G
V
T
F
N------
40
HHSearch
90.26
68%
-113
- C3 -
2BTU
-
PUR5_BACAN
A:
[13-341]
------------
E
A
G
Y
E
A
V
S
R
M
K
K
H
V
Q
T
T
M
R
K
E
V
L
G-
G
F
G
G
M
F
D
L
S
K
F
A
L
E
E
---------
P
V
L
V
S
G
T
D
G
V
G
T
K
L
M
L
A
F
M
A
D
K
H
D
T
I
G
I
D
A
V
A
M
C
V
N
D
I
V
V
Q
G
A
E
P
L
F
F
L
D
Y
I
A
C
G
K
A
E
P
S
K
I
E
N
I
V
K
G
I
S
E
G
C
R
Q
A
G
C
A
L
I
G
G
E
T
A
E
M
P
G
M
Y
S
T
E
E
Y
D
L
A
G
F
T
V
G
I
V
D
K
K
K
I
V
T
G
E
K
I
E
A
G
H
V
L
I
G
L
A
S
S
G
I
H
S
N
G
Y
S
L
V
R
K
V
L
L
E
D
G
E
L
----
I
Y
-
G
R-
L
E
--
L
P
L
G
E
E
L
L
K
P
T
K
I
Y
V
K
P
I
L
E
L
L
K
N
H
-
E
V
Y
G
M
A
H
I
T
G
G
G
F
I
E
N
I
P
R
M
L
P
E
G
I
G
A
E
I
E
L
G
S
W
K
I
Q
P
I
F
S
L
L
Q
E
V
G
K
L
E
E
K
E
M
F
N
I
F
N
M
G
I
G
M
V
V
A
V
K
E
E
D
A
K
D
I
V
R
L
L
E
E
Q
-
G
E
T
A
R
I
I
G
R
T
V
Q
G
A
G
V
T
F
-
N
-----
22
PsiBlast_CBE
85.81
51%
-104
- C3 -
1CLI
1
PUR5_ECOLI
C:
[6-337]
-
S
L
S
Y
K
D
A
G
V
D
I
D
A
G
N
A
L
V
G
R
I
K
G
V
V
K
K
T
R
R
P
E
V
M
-
G
G
L
G
--
G
F
G
A
L
C
A
L
P
Q
-----
K
Y
R
E
P
V
L
V
S
G
T
D
G
V
G
T
K
L
R
L
A
M
D
L
K
R
H
D
T
I
G
I
D
L
V
A
M
C
V
N
D
L
V
V
Q
G
A
E
P
L
F
F
L
D
Y
Y
A
T
G
K
L
D
V
D
T
A
S
A
V
I
S
G
I
A
E
G
C
L
Q
S
G
C
S
L
V
G
G
E
T
A
E
M
P
G
M
Y
H
G
E
D
Y
D
V
A
G
F
C
V
G
V
V
E
K
S
E
I
I
D
G
S
K
V
S
D
G
D
V
L
I
A
L
G
S
S
G
P
H
S
N
G
Y
S
L
V
R
K
I
-
L
E
V
S
G
C
D
P
Q
T
T
--
E
--
L
D
G
-
K
P
L
A
D
H
L
L
A
P
T
R
I
Y
V
K
S
V
L
E
L
I
E
K
V
-
D
V
H
A
I
A
H
L
T
G
G
G
F
W
E
N
I
P
R
V
L
P
D
N
T
Q
A
V
I
D
E
S
S
W
Q
W
P
E
V
F
N
W
L
Q
T
A
G
N
V
E
H
H
E
M
Y
R
T
F
N
C
G
V
G
M
I
I
A
L
P
A
P
E
V
D
K
A
L
A
L
L
N
A
N
-
G
E
N
A
W
K
I
G
I
I
K
A
S
D
-----------
23
PsiBlast_CBE
84.78
51%
-114
- C3 -
1CLI
1
PUR5_ECOLI
B:
[21-337]
----------------
A
L
V
G
R
I
K
G
V
V
K
K
T
R
R
P
E
V
M
-
G
G
L
G
--
G
F
G
A
L
C
A
L
P
Q
-----
K
Y
R
E
P
V
L
V
S
G
T
D
G
V
G
T
K
L
R
L
A
M
D
L
K
R
H
D
T
I
G
I
D
L
V
A
M
C
V
N
D
L
V
V
Q
G
A
E
P
L
F
F
L
D
Y
Y
A
T
G
K
L
D
V
D
T
A
S
A
V
I
S
G
I
A
E
G
C
L
Q
S
G
C
S
L
V
G
G
E
T
A
E
M
P
G
M
Y
H
G
E
D
Y
D
V
A
G
F
C
V
G
V
V
E
K
S
E
I
I
D
G
S
K
V
S
D
G
D
V
L
I
A
L
G
S
S
G
P
H
S
N
G
Y
S
L
V
R
K
I
-
L
E
V
S
G
C
D
P
Q
T
T
--
E
--
L
D
G
-
K
P
L
A
D
H
L
L
A
P
T
R
I
Y
V
K
S
V
L
E
L
I
E
K
V
-
D
V
H
A
I
A
H
L
T
G
G
G
F
W
E
N
I
P
R
V
L
P
D
N
T
Q
A
V
I
D
E
S
S
W
Q
W
P
E
V
F
N
W
L
Q
T
A
G
N
V
E
H
H
E
M
Y
R
T
F
N
C
G
V
G
M
I
I
A
L
P
A
P
E
V
D
K
A
L
A
L
L
N
A
N
-
G
E
N
A
W
K
I
G
I
I
K
A
S
D
-----------
3
PsiBlast_PDB
84.52
51%
-105
- C3 -
1CLI
1
PUR5_ECOLI
A:
[6-337]
-
S
L
S
Y
K
D
A
G
V
D
I
D
A
G
N
A
L
V
G
R
I
K
G
V
V
K
K
T
R
R
P
E
V
M
-
G
G
L
G
--
G
F
G
A
L
C
A
L
P
Q
-----
K
Y
R
E
P
V
L
V
S
G
T
D
G
V
G
T
K
L
R
L
A
M
D
L
K
R
H
D
T
I
G
I
D
L
V
A
M
C
V
N
D
L
V
V
Q
G
A
E
P
L
F
F
L
D
Y
Y
A
T
G
K
L
D
V
D
T
A
S
A
V
I
S
G
I
A
E
G
C
L
Q
S
G
C
S
L
V
G
G
E
T
A
E
M
P
G
M
Y
H
G
E
D
Y
D
V
A
G
F
C
V
G
V
V
E
K
S
E
I
I
D
G
S
K
V
S
D
G
D
V
L
I
A
L
G
S
S
G
P
H
S
N
G
Y
S
L
V
R
K
I
-
L
E
V
S
G
C
D
P
Q
T
T
--
E
--
L
D
G
-
K
P
L
A
D
H
L
L
A
P
T
R
I
Y
V
K
S
V
L
E
L
I
E
K
V
-
D
V
H
A
I
A
H
L
T
G
G
G
F
W
E
N
I
P
R
V
L
P
D
N
T
Q
A
V
I
D
E
S
S
W
Q
W
P
E
V
F
N
W
L
Q
T
A
G
N
V
E
H
H
E
M
Y
R
T
F
N
C
G
V
G
M
I
I
A
L
P
A
P
E
V
D
K
A
L
A
L
L
N
A
N
-
G
E
N
A
W
K
I
G
I
I
K
A
S
D
-----------
39
HHSearch
84.22
51%
-109
* C3 *
3P4E
4
PUR5_VIBCH
A:
[21-342]
------------
D
A
G
N
A
L
V
E
R
I
K
G
A
V
K
R
T
R
R
P
E
V
M
-
G
--------
A
L
C
E
L
P
T
--
K
---
Y
K
H
P
V
L
V
S
G
T
D
G
V
G
T
K
L
R
L
A
L
D
M
K
K
H
D
T
I
G
I
D
L
V
A
M
C
V
N
D
L
I
V
Q
G
A
E
P
L
F
F
L
D
Y
Y
A
T
G
K
L
D
V
D
T
A
A
E
V
I
S
G
I
A
D
G
C
L
Q
A
G
C
A
L
I
G
G
E
T
A
E
M
P
G
M
Y
E
G
E
D
Y
D
V
A
G
F
C
V
G
V
V
E
K
E
E
I
I
D
G
S
K
V
Q
V
G
D
A
L
I
A
V
G
S
S
G
P
H
S
N
G
Y
S
L
V
R
K
I
L
E
V
S
K
A
-
D
K
N
E
R
L
----
A
G
--
K
T
I
G
E
H
L
L
A
P
T
K
I
Y
I
K
S
G
L
K
L
I
A
E
H
-
D
I
H
A
I
S
H
I
T
G
G
G
F
W
E
N
I
P
R
V
L
P
E
G
T
K
A
V
I
D
G
K
S
W
E
W
P
V
I
F
Q
W
L
Q
E
K
G
N
V
T
T
H
E
M
Y
R
T
F
N
C
G
V
G
L
I
I
A
L
P
K
D
Q
A
N
A
A
V
A
L
L
Q
A
E
-
G
E
T
A
W
V
I
G
E
I
A
A
A
N
S
N
---------
21
PsiBlast_CBE
83.87
51%
-107
- C3 -
1CLI
1
PUR5_ECOLI
D:
[21-337]
----------------
A
L
V
G
R
I
K
G
V
V
K
K
T
R
R
P
E
V
M
-
G
G
L
G
--
G
F
G
A
L
C
A
L
P
Q
-----
K
Y
R
E
P
V
L
V
S
G
T
D
G
V
G
T
K
L
R
L
A
M
D
L
K
R
H
D
T
I
G
I
D
L
V
A
M
C
V
N
D
L
V
V
Q
G
A
E
P
L
F
F
L
D
Y
Y
A
T
G
K
L
D
V
D
T
A
S
A
V
I
S
G
I
A
E
G
C
L
Q
S
G
C
S
L
V
G
G
E
T
A
E
M
P
G
M
Y
H
G
E
D
Y
D
V
A
G
F
C
V
G
V
V
E
K
S
E
I
I
D
G
S
K
V
S
D
G
D
V
L
I
A
L
G
S
S
G
P
H
S
N
G
Y
S
L
V
R
K
I
-
L
E
V
S
G
C
D
P
Q
T
T
--
E
--
L
D
G
-
K
P
L
A
D
H
L
L
A
P
T
R
I
Y
V
K
S
V
L
E
L
I
E
K
V
-
D
V
H
A
I
A
H
L
T
G
G
G
F
W
E
N
I
P
R
V
L
P
D
N
T
Q
A
V
I
D
E
S
S
W
Q
W
P
E
V
F
N
W
L
Q
T
A
G
N
V
E
H
H
E
M
Y
R
T
F
N
C
G
V
G
M
I
I
A
L
P
A
P
E
V
D
K
A
L
A
L
L
N
A
N
-
G
E
N
A
W
K
I
G
I
I
K
A
S
D
-----------
41
HHSearch
83.05
43%
-102
- C3 -
3M84
13
?
A:
[5-347]
A
G
L
K
Y
E
D
A
G
V
N
I
E
A
G
N
Q
A
V
E
R
M
K
Q
H
V
K
K
T
F
T
Q
D
V
L
-
T
G
L
G
--
S
F
G
S
L
Y
S
L
K
N
I
I
N
--
N
Y
D
D
P
V
L
V
Q
S
I
D
G
V
G
T
K
T
K
V
A
V
M
C
G
K
F
E
N
L
G
Y
D
L
F
S
A
A
T
N
D
I
V
V
M
G
A
K
P
I
T
F
L
D
Y
V
A
H
D
K
L
D
P
A
I
M
E
E
L
V
K
G
M
S
K
A
C
A
E
C
G
V
S
L
V
G
G
E
T
A
E
M
P
G
V
Y
Q
A
G
E
I
D
M
V
G
V
I
T
G
I
V
D
R
K
R
I
I
N
G
E
N
I
K
E
G
D
I
V
F
G
L
S
S
S
G
L
H
T
N
G
Y
S
F
A
R
K
L
F
F
D
V
A
G
N
K
H
T
D
T
Y
-
P
EL
E
G
--
K
T
I
G
D
V
L
L
E
P
H
I
N
Y
T
N
I
I
H
D
F
L
D
N
G
V
D
I
K
G
M
A
H
I
T
G
G
G
F
I
E
N
I
P
R
V
L
P
Q
G
L
G
A
Q
I
D
K
D
S
F
A
T
P
A
I
F
K
L
M
Q
R
I
G
D
I
S
E
F
E
M
Y
R
S
F
N
M
G
I
G
M
T
I
I
A
S
Q
D
Q
F
D
K
M
Q
E
L
A
K
K
H
T
N
T
K
L
Y
Q
I
G
K
I
T
N
S
G
K
V
---------
4
PsiBlast_PDB
82.97
51%
-111
- C3 -
3P4E
4
PUR5_VIBCH
A:
[21-336]
------------
D
A
G
N
A
L
V
E
R
I
K
G
A
V
K
R
T
R
R
P
E
V
M
-
G
--------
A
L
C
E
L
P
T
-----
K
Y
K
H
P
V
L
V
S
G
T
D
G
V
G
T
K
L
R
L
A
L
D
M
K
K
H
D
T
I
G
I
D
L
V
A
M
C
V
N
D
L
I
V
Q
G
A
E
P
L
F
F
L
D
Y
Y
A
T
G
K
L
D
V
D
T
A
A
E
V
I
S
G
I
A
D
G
C
L
Q
A
G
C
A
L
I
G
G
E
T
A
E
M
P
G
M
Y
E
G
E
D
Y
D
V
A
G
F
C
V
G
V
V
E
K
E
E
I
I
D
G
S
K
V
Q
V
G
D
A
L
I
A
V
G
S
S
G
P
H
S
N
G
Y
S
L
V
R
K
I
L
----
E
V
S
K
A
D
K
N
-
E
--
R
L
A
G
K
T
I
G
E
H
L
L
A
P
T
K
I
Y
I
K
S
G
L
K
L
I
A
E
H
-
D
I
H
A
I
S
H
I
T
G
G
G
F
W
E
N
I
P
R
V
L
P
E
G
T
K
A
V
I
D
G
K
S
W
E
W
P
V
I
F
Q
W
L
Q
E
K
G
N
V
T
T
H
E
M
Y
R
T
F
N
C
G
V
G
L
I
I
A
L
P
K
D
Q
A
N
A
A
V
A
L
L
Q
A
E
-
G
E
T
A
W
V
I
G
E
I
---------------
7
PsiBlast_PDB
82.46
42%
-107
- C3 -
3M84
13
?
A:
[9-341]
----
Y
E
D
A
G
V
N
I
E
A
G
N
Q
A
V
E
R
M
K
Q
H
V
K
K
T
F
T
Q
D
V
L
-
T
G
L
G
--
S
F
G
S
L
Y
S
L
K
N
--
I
I
N
N
Y
D
D
P
V
L
V
Q
S
I
D
G
V
G
T
K
T
K
V
A
V
M
C
G
K
F
E
N
L
G
Y
D
L
F
S
A
A
T
N
D
I
V
V
M
G
A
K
P
I
T
F
L
D
Y
V
A
H
D
K
L
D
P
A
I
M
E
E
L
V
K
G
M
S
K
A
C
A
E
C
G
V
S
L
V
G
G
E
T
A
E
M
P
G
V
Y
Q
A
G
E
I
D
M
V
G
V
I
T
G
I
V
D
R
K
R
I
I
N
G
E
N
I
K
E
G
D
I
V
F
G
L
S
S
S
G
L
H
T
N
G
Y
S
F
A
R
K
L
F
F
D
V
A
G
N
K
H
T
D
T
Y
-
P
--
E
L
E
G
K
T
I
G
D
V
L
L
E
P
H
I
N
Y
T
N
I
I
H
D
F
L
D
N
G
V
D
I
K
G
M
A
H
I
T
G
G
G
F
I
E
N
I
P
R
V
L
P
Q
G
L
G
A
Q
I
D
K
D
S
F
A
T
P
A
I
F
K
L
M
Q
R
I
G
D
I
S
E
F
E
M
Y
R
S
F
N
M
G
I
G
M
T
I
I
A
S
Q
D
Q
F
D
K
M
Q
E
L
A
K
K
H
T
N
T
K
L
Y
Q
I
G
K
I
---------------
8
PsiBlast_PDB
82.20
42%
-106
- C3 -
3QTY
6
?
A:
[9-341]
----
Y
E
D
A
G
V
N
I
E
A
G
N
Q
A
V
E
R
M
K
Q
H
V
K
K
T
F
T
Q
D
V
L
-
T
G
L
G
--
S
F
G
S
L
Y
S
L
K
N
--
I
I
N
N
Y
D
D
P
V
L
V
Q
S
I
D
G
V
G
T
K
T
K
V
A
V
M
C
G
K
F
E
N
L
G
Y
D
L
F
S
A
A
T
N
D
I
V
V
M
G
A
K
P
I
T
F
L
D
Y
V
A
H
D
K
L
D
P
A
I
M
E
E
L
V
K
G
M
S
K
A
C
A
E
C
G
V
S
L
V
G
G
E
T
A
E
M
P
G
V
Y
Q
A
G
E
I
D
M
V
G
V
I
T
G
I
V
D
R
K
R
I
I
N
G
E
N
I
K
E
G
D
I
V
F
G
L
S
S
S
G
L
H
T
N
G
Y
S
F
A
R
K
L
F
F
D
V
A
G
N
K
H
T
D
T
Y
-
P
--
E
L
E
G
K
T
I
G
D
V
L
L
E
P
H
I
N
Y
T
N
I
I
H
D
F
L
D
N
G
V
D
I
K
G
M
A
H
I
T
G
G
G
F
I
E
N
I
P
R
V
L
P
Q
G
L
G
A
Q
I
D
K
D
S
F
A
T
P
A
I
F
K
L
M
Q
R
I
G
D
I
S
E
F
E
M
Y
R
S
F
N
M
G
I
G
M
T
I
I
A
S
Q
D
Q
F
D
K
M
Q
E
L
A
K
K
H
T
N
T
K
L
Y
Q
I
G
K
I
---------------
28
PsiBlast_CBE
79.54
44%
-116
- C3 -
5AVM
2
?
E:
[53-332]
------------------------------------------------------------
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
---
A
G
Q
D
L
S
A
P
V
-
P
--
E
L
G
-
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
G
------
F
L
V
G
R
V
V
P
G
E
G
V
R
L
-------
25
PsiBlast_CBE
78.50
44%
-125
- C3 -
5AVM
3
?
H:
[51-332]
----------------------------------------------------------
L
E
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
---
A
G
Q
D
L
S
A
P
V
-
P
--
E
L
G
-
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
G
------
F
L
V
G
R
V
V
P
G
E
G
V
R
L
-------
37
HHSearch
78.10
46%
-118
- C3 -
5AVM
3
?
A:
[53-330]
------------------------------------------------------------
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
A
G
Q
---
D
L
S
A
P
V
-
P
E-
L
G
--
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
------
G
F
L
V
G
R
V
V
P
G
E
G
V
---------
27
PsiBlast_CBE
77.94
44%
-123
- C3 -
5AVM
1
?
F:
[51-332]
----------------------------------------------------------
L
E
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
---
A
G
Q
D
L
S
A
P
V
-
P
--
E
L
G
-
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
G
------
F
L
V
G
R
V
V
P
G
E
G
V
R
L
-------
26
PsiBlast_CBE
77.90
44%
-116
- C3 -
5AVM
3
?
G:
[53-332]
------------------------------------------------------------
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
---
A
G
Q
D
L
S
A
P
V
-
P
--
E
L
G
-
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
G
------
F
L
V
G
R
V
V
P
G
E
G
V
R
L
-------
29
PsiBlast_CBE
77.73
44%
-119
- C3 -
5AVM
3
?
D:
[51-332]
----------------------------------------------------------
L
E
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
---
A
G
Q
D
L
S
A
P
V
-
P
--
E
L
G
-
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
G
------
F
L
V
G
R
V
V
P
G
E
G
V
R
L
-------
6
PsiBlast_PDB
77.68
44%
-118
- C3 -
5AVM
3
?
A:
[53-332]
------------------------------------------------------------
E
P
V
L
V
A
T
T
D
G
V
G
T
K
T
L
L
A
L
E
A
G
D
V
S
G
L
G
F
D
L
V
N
H
S
V
N
D
L
L
A
Q
G
A
E
P
L
F
F
L
D
Y
L
A
A
S
H
L
D
E
G
V
L
A
A
L
L
A
S
L
A
E
A
C
R
A
H
G
I
P
L
L
G
G
E
T
A
E
M
P
G
V
Y
R
E
G
A
W
D
I
A
G
T
L
V
G
V
V
E
R
S
R
I
L
G
P
E
R
V
R
E
G
D
A
L
L
A
L
P
S
S
G
P
H
T
N
G
Y
S
L
I
R
K
V
V
---
A
G
Q
D
L
S
A
P
V
-
P
--
E
L
G
-
E
S
L
K
E
A
L
L
R
P
H
R
A
Y
L
K
E
F
R
L
L
W
E
A
G
V
E
L
H
A
A
A
H
I
T
G
G
G
L
P
E
N
L
P
R
A
L
P
P
G
L
G
A
E
V
R
R
G
S
W
P
I
P
P
V
F
P
Y
L
Q
R
L
G
G
I
P
E
E
E
M
Y
R
V
F
N
M
G
L
G
M
V
L
V
L
P
Q
E
A
A
E
E
A
L
K
L
V
E
G
------
F
L
V
G
R
V
V
P
G
E
G
V
R
L
-------