@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu06660: (2016-06-10 )
MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFVTALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAADDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKLGLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEIDAVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWMIITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMSSISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTILDLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVYEIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK
Atome Classification :
(20 SA)
-----......-------------------...10........20........30...-----.....40--.....------...50......---...60---....-----------.....70.-----...-----....80........90........100-------------------.-...------..-------------------------------.110.......120..--------.....130-.....---------..140.......150--....-----.-.--.--160......----...170.......180....----------------------...190.......200..--...-.---.-210-----------......--..---.220.--------....----.-.-230----------.-..---.---.--..240---.-...---....-.250..-....--------.260-----..-.......270.......280.....-..290...--...--------.300.-------------......310---------.---------------....-....320-....--------.--.---------------...330....-...340--......-------..350---.......360---------------........----370------------------.......380------.--..-----...--.390---.......---------..400.....---..410--.........420---------------.-------------------.----......430.....---..440.......450---....--..-------.460-----.......470.--------------------......480-........490----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
S
I
E
I
I
-------------------
I
S
L
G
I
Y
F
I
A
M
L
L
I
G
W
Y
A
FKKTTDIND
Y
M
-----LGGRG
L
G
--
P
F
V
T
A
------
L
SAG-AADMS
G
---
W
M
L
M----GV
P
G
-----------
A
M
F
A
T
G
L
S
-----
T
L
W
-----
L
A
L
G
L
T
IGAYS
N
Y
L
L
L
A
P
R
L
R
A
Y
T
EAA-------------------D-D
A
I
------T
I
-------------------------------
P
D
F
F
D
K
R
F
Q
H
S
S
S
L
L
K
--------
I
V
S
A
L
I
I
M
-
I
F
F
T
L
---------YTSSGMVSG
G
R
L
F
E
S
--AFGA-----D-
Y
--
K
--
L
--
G
L
F
L
T
T
----
A
V
V
V
L
Y
T
L
F
G
G
F
L
A
V
S
L
T
D
F
----------------------
V
Q
G
A
I
M
F
A
A
L
V
L
V
P
I
V
A
F
--THV-G---G-V-------------APT
F
H
E--ID---AVN
P
H
--------
L
L
D
I
----F-K-G
A
S
----------
V
-
I
S
---
I
---
I
--
S
Y
L
-----
A
-
W
G
L
---GYYG-Q
P
H
I
I
V
-
R
F
M
A--------IK-------
D
I
-
K
DL
K
P
A
R
R
IG
M
S
W
M
I
I
T
V
L
G
S
V
L
T
G
-
L
I
G
V
A
Y
A
H
--KFG--------VAVKD-------------PE
M
I
F
I
I
-----------
F
---------------
S
K
I
L
-
F
H
P
L
I
---
T
G
F
L
--------
L
--
S
---------------
A
I
L
A
A
I
M
S
S
I
-
S
S
Q
L
L
---
V
T
A
S
A
V
-------
T
E
D
L
Y
---
R
S
F
F
R
RKAS----------------DK
E
L
V
M
I
G
----
R
L
S
------------------
V
L
V
I
A
V
I
A
V
L
------
L
--SL-----NPN--
S
T
-----
I
L
D
L
V
G
Y
---------
A
W
AGFG
S
A
F
G
---
P
A
I
----
L
L
S
L
Y
W
K
R
M
N
E
----------------
W
-------------------
G
----
A
L
A
A
M
I
V
G
A
A
T
V
L
I
---
W
I
TTGLAKSTG
V
Y
E
I
---
I
P
G
F
--
I
L
-------
S
M
I
A
-----
G
I
I
V
S
M
I
TKRP--------------------A
K
A
S
Y
R
L
F
--
G
V
M
E
K
L
L
KRKK----
15
HHSearch
92.47
20%
-165
- C2 -
2XQ2
3
SGLT_VIBPH
A:
[9-506]
------
S
F
I
D
I
-------------------
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
--------------------
L
P
--
W
W
A
V
G
------
A
S
L
I
-
A
A
N
I
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A
---
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Q
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I
----
G
M
S
G
-----------
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Y
S
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G
L
A
-----
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A
S
-----
Y
E
W
M
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A
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I
V
G
K
Y
F
L
P
I
F
I
E
K
-------------------------
G
I
Y
------
T
I
-------------------------------
P
E
F
V
E
K
R
F
-
N
-
K
-
K
L
K
--------
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
---------
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
--
I
L
G
I
-----
P
-
L
--
M
--
Y
--
S
I
L
G
L
A
----
L
F
A
L
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
----------------------
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
--
S
F
I
-
G
---
G
-
T
-------------
D
G
W
F
A
G
--
V
S
K
M
V
D
A
A
P
G
--------
H
F
E
M
ILDQ
S
N
P
Q
Y
M
N
----------
L
-
P
G
---
I
AVL
I
GG
L
W
V
-----
A
-
N
L
Y
---
Y
W
G
F
-
N
Q
Y
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Q
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L
A
--------
A
K
-------
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V
-
S
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A
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K
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F
A
A
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A
L
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V
L
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-
I
A
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Y
V
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--
D
P
Q
L
M
A
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L
GNL
P
S
A
A
N
-------------
A
D
K
A
Y
P
W
-----------
L
---------------
T
-
Q
F
-
L
P
V
G
V
---
K
G
V
V
--------
F
--
A
---------------
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
---
S
T
A
T
I
F
-------
T
M
D
I
Y
---
K
E
Y
I
S
P
D
S
G
----------------
D
H
K
L
V
N
V
G
----
R
T
A
------------------
A
V
V
A
L
I
I
A
A
L
------
I
--
A
P
-----
M
L
G
GI
G
Q
-----
C
F
Q
Y
I
Q
E
---------
Y
T
G
L
V
S
P
G
I
L
---
A
V
F
----
L
L
G
L
F
W
K
K
T
T
S
----------------
K
-------------------
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
---
L
K
F
M
P
L
-
S
M
P
F
M
D
Q
M
---
L
Y
T
L
--
L
F
-------
T
M
V
V
-----
I
A
F
T
S
L
S
T
S
I
N
--------------------
D
D
-----------------------
17
HHSearch
69.63
13%
-169
* C2 *
2JLN
2
?
A:
[23-456]
----------------------------------------------------------------
A
E
R
S
V
G
--
P
F
S
L
A
------
A
I
W
F
-
A
M
A
I
Q
V
---
A
I
F
I
----
A
A
G
Q
-------------
M
T
S
S
F
Q
-----
V
W
Q
-----
V
I
V
A
I
A
A
G
C
T
I
A
-
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
---------------------
G
-
I
------
N
F
-------------------------------
T
V
A
A
R
M
P
F
-
G
-
I
R
-
G
S
--------
L
I
P
I
T
L
K
A
-
L
L
S
L
F
---------
W
F
G
F
Q
T
W
L
G
A
L
A
L
D
E
--
I
T
R
L
L
TGFT
N
-
L
--
P
--
L
--
W
I
V
I
F
G
----
A
I
Q
V
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
----------------------
F
A
S
P
V
L
L
A
M
G
V
Y
M
V
Y
L
M
L
--
D
G
A
-
D
---
V
S
L
-------------
G
E
V
M
S
M
--
G
G
-------
E
----------------
N
-
P
-
G
M
P
----------
F
-
S
T
---
A
---
I
M
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-----
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G
W
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---
A
V
V
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-
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K
E
C
K
VDPNAS
R
E
G
Q
-------
T
K
-
A
D
A
R
Y
A
T
A
-
Q
W
L
G
M
V
P
A
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I
I
F
G
F
I
G
-
A
A
S
M
V
L
V
G
----
E
-----------
W
N
-------------
P
V
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A
I
T
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-----------
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---------------
V
G
G
--
V
S
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P
M
---
A
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L
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--------
Q
--
V
---------------
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
---
S
P
A
Y
T
L
-------
C
S
-
T
F
---
P
R
V
F
T
--------------------------
F
K
----
T
G
-------------------
V
I
V
S
A
V
V
G
L
L
------
M
--
M
P
-----
W
Q
F
--
A
G
-----
V
L
N
T
F
L
N
---------
L
L
A
S
A
L
G
P
L
A
---
G
I
M
----
I
S
D
Y
F
L
V
R
R
R
R
IS
L
H
D
L
Y
RTKGIYTYW
R
-------------------
G
VN
W
V
A
L
A
V
Y
A
V
A
L
A
V
S
F
L
---
T
P
D
---------
L
M
F
---
V
T
G
L
--
I
A
-------
A
L
L
L
-----
H
I
P
A
M
R
W
V
A
K
T
--------------------
F
P
L
F
S
--------------------
25
Fugue
68.37
20%
-114
- C2 -
3DH4
4
?
A:
[52-518]
----------------------------------------------------------------
A
G
K
S
L
P
--
W
W
A
V
G
------
A
S
L
I
-
A
A
N
I
S
A
---
E
Q
F
I
----
G
M
S
G
-----------
S
G
Y
S
I
G
L
A
-----
I
A
S
-----
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
F
I
E
------------------------
K
-
G
I
Y
------
T
I
-------------------------------
P
E
F
V
E
K
R
F
--
N
K
K
L
K
T
--------
I
L
A
V
F
W
I
S
-
L
Y
I
F
V
---------
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
--
I
L
G
I
-----
P
-
L
--
M
--
Y
--
S
I
L
G
L
A
----
L
F
A
L
V
Y
S
------
I
V
V
W
T
D
V
----------------------
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Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
--
S
F
I
-
G
GTD
G
-
W
-------------
F
A
G
V
S
K
--
M
V
---
D
A
A
P
G
--------
H
F
E
M
----
I
-
L
-
D
Q
S
NPQYMNLPGI
A
-
V
L
---
I
---
G
--
G
L
W
-----
V
-
A
N
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---
Y
Y
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Q
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L
A
--------
A
K
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S
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A
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K
G
I
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F
A
A
F
L
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L
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G
-
I
A
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Y
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I
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--
D
P
Q
--------
L
M
A
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L
GDIAATNLPSAAN
A
D
K
A
Y
P
W
-----------
L
---------------
T
Q
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L
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P
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G
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---
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G
V
V
--------
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A
---------------
A
L
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S
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L
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A
S
M
L
N
---
S
T
A
T
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M
D
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Y
---
K
E
Y
I
S
P
D
S
G
----------------
D
H
K
L
V
N
V
G
----
R
T
A
------------------
A
V
V
A
L
I
I
A
C
L
------
I
AP
M
L
-----
G
G
I
--
G
Q
-----
A
F
Q
Y
I
Q
E
---------
Y
T
G
L
V
S
P
G
I
L
---
A
V
F
----
L
L
G
L
F
W
K
K
T
T
S
----------------
K
-------------------
G
----
A
I
I
G
V
V
A
S
I
P
F
A
L
F
---
L
K
F
M
P
L
S
M
P
-
F
M
D
Q
M
---
L
Y
T
L
--
L
F
-------
T
M
V
V
-----
I
A
F
T
S
L
S
T
S
I
N
DDDPKGISVTSSMFVTD
R
S
F
N
I
A
A
Y
G
I
M
--
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
32
Fugue
64.53
18%
-176
- C1 -
5CA8
2
SEY1_CANAL
A:
[27-687]
-----
D
A
I
Q
I
I
DENKHFNTG
I
L
D
Y
I
N
K
T
S
P
A
D
V
G
N
N
Y
H
I
I
S
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F
G
S
Q
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G
K
S
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L
L
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L
F
NTNFD
V
M
G
I
W
L
A
Y
S
P
V
V
S
T
------
T
L
G
H
-
T
T
S
K
S
N
---
I
L
V
M
----
D
V
E
G
TDED
Q
D
F
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R
K
A
A
L
F
A
L
S
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S
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V
L
I
I
N
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W
E
TQVG
L
Y
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G
A
N
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G
L
L
K
T
V
F
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V
N
L
S
L
F
G
K
S
K
L
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THND
H
K
V
L
L
L
I
V
I
R
DHVGV
T
-
P
V
E
------
S
L
-------------------------------
A
K
T
F
T
L
D
L
Q
N
M
W
S
S
L
A
KPAELEHL
Q
F
A
D
F
F
D
V
-
T
F
H
A
L
N
HKVLQ
P
K
E
F
G
E
G
I
N
R
L
G
D
R
L
V
V
S
NE
L
F
K
P
-----
E
-
Y
--
H
--
H
--
D
V
P
I
D
G
----
W
T
M
Y
A
E
R
C
W
E
Q
I
E
T
N
K
D
L
D
L
----------------------
P
T
Q
Q
I
L
V
A
Q
F
K
C
D
E
I
V
E
S
--
V
F
Q
-
E
---
F
-
L
-------------
T
K
Y
Q
H
H
--
F
K
---
E
V
D
A
A
PDFEEL
G
A
L
F
A
D
----
L
-
R
-
Q
D
A
----------
F
-
E
D
---
Y
---
D
--
A
S
A
-----
S
R
Y
N
K
---
A
V
Y
E
-
Q
K
R
K
K
L
-
R
W
L
I
--------
N
D
-------
K
L
-
K
E
V
F
D
V
H
A
K
N
L
C
N
T
L
L
E
K
F
E
K
D
L
V
A
-
L
K
G
K
D
F
A
V
N
V
K
T
L
--------
S
T
K
L
V
-------------
E
D
V
N
F
Q
V
-----------
S
---------------
L
M
S
L
-
Q
G
D
L
S
---
L
D
E
I
--------
I
--
L
---------------
A
L
T
K
D
I
D
A
I
V
-
A
K
Q
Q
V
---
V
E
L
N
S
I
-------
V
N
K
S
V
---
K
K
L
S
A
S
L
S
K
----------------
S
I
Q
F
E
L
G
D
PNEE
T
W
D
------------------
N
V
L
Q
Q
F
K
G
V
Y
E
KFGGD
F
--
G
L
-----
G
T
S
--
S
T
Q
N
Q
Q
A
I
E
K
F
K
F
K
---------
S
W
C
Q
F
Y
D
V
T
H
---
K
L
I
S
R
E
K
L
L
A
L
L
Q
D
R
F
D
D
----------------
K
FRYDENG
L
P
K
L
Y
LN
E
Q
D
L
E
K
----
T
F
A
V
A
K
Q
H
A
L
Q
V
L
P
---
I
L
T
--
F
A
K
L
A
D
G
S
E
I
---
V
P
D
Y
--
D
I
FDSKLRE
Q
F
L
D
-----
H
C
F
A
E
I
I
T
E
Q
E
--------------------
K
L
E
V
L
A
K
F
K
K
E
V
D
A
K
Y
I
E
T
K
R
S
I
V-
27
Fugue
63.46
19%
-120
- C3 -
4K7J
4
?
A:
[26-375]
---------------------------------------------------
G
L
L
T
D
Y
-----------------------------
G
-
N
A
S
A
S
P
---
W
M
K
K
-----
L
Q
S
-----------
V
A
Q
G
S
G
E
T
-----
F
R
I
-----
L
Q
I
G
D
S
H
T
A
-
G
D
F
F
T
D
S
L
R
K
R
L
Q
K
T
W
G
-------------------
D
-
G
G
I
GWVYPA
N
V
-------------------------------
K
G
Q
R
M
A
A
V
R
H
N
G
N
W
Q
S
--------
L
T
S
R
-------------------
N
N
T
G
D
F
P
L
G
G
I
L
A
H
T
--
G
S
G
G
-----
S
-
M
--
T
--
L
--
T
A
S
D
G
I
----
A
S
K
Q
R
V
S
L
F
A
K
P
L
L
A
E
Q
T
L
T
----------------------
V
N
G
---------------------------------------------
N
T
--
V
S
---
A
N
G
G
G
--------
W
Q
V
L
----
D
-
T
-
G
A
A
----------
L
P
L
T
---
I
---
H
--
T
E
M
-----
P
-
W
D
I
---
G
F
I
N
-
I
E
N
--------------------------------
P
A
G
G
I
T
V
S
A
M
G
I
N
--
G
A
Q
L
T
Q
-
W
S
K
W
R
A
D
R
--
M
N
D
--------
L
A
Q
T
G
-------------
A
D
L
V
I
L
S
-----------
Y
G--------------
T
N
E
A
-
F
N
N
N
I
---
D
------------------------------------
I
A
D
T
-
E
Q
K
W
L
---
D
T
V
R
Q
I
-------
R
D
S
L
P
---
A
A
-------------------------------------
G
------------------
I
L
I
I
G
A
P
E
S
L
------
K
--
N
T
LGVC-
G
T
R
--
P
V
-----
R
L
T
E
V
Q
Q
---------
M
Q
R
R
V
A
R
Q
G
Q
------------
T
M
F
W
S
----------------------------------------------
W
Q
N
A
M
G
G
I
C
S
M
K
N
---
W
L
N
Q
G
W
A
A
K
D
G
V
H
----------------------------------
F
S
A
K
G
Y
--------------------
R
R
A
A
E
M
L
A
--
D
S
L
E
E
L
V
R
S
A
-----
34
Fugue
62.12
21%
-131
- C3 -
4B46
1
CETZ1_HALVD
A:
[1-367]
-----------------------------------
M
K
L
A
M
I
G
F
G
-
Q
A
G
G
K
V
V
D
K
F
V
E
Y
-----
D
R
E
R
N
A
G
--
I
V
R
A
A
------
V
A
V
N
-
S
A
K
A
D
L
---
L
G
L
K
----
N
I
P
K
-----------
D
Q
------------------------------
R
V
L
I
G
Q
S
R
V
K
G
H
G
-----------------------------------------------------------------------------------------------------------------------------------
V
G
A
-----
D
-
N
--
E
--
L
--
G
A
E
I
A
E
----
E
D
---------------
I
D
E
----------------------
V
Q
G
A
I
------------------------------------------------
D
---
S
I
P
V
H
--------
E
V
D
----------------------
A
-
F
L
---
V
---
V
--
S
G
L
-----
G
-
G
G
T
---
G
S
G
G
-
A
P
V
L
A
K
-
H
L
K
R
--------
I
Y
--------------
T
E
P
V
Y
G
L
G
I
L
P
----
G
S
D
E
G
G
-
I
Y
T
L
N
A
A
R
--
S
F
Q
--------
T
F
V
R
E
-------------
V
D
N
L
L
V
F
-----------
D
---------------
N
D
A
W
-
R
K
T
G
E
---
S
V
Q
G
--------
G
--
Y
---------------
D
E
I
N
E
E
I
V
N
R
-
F
G
V
L
F
GSV
V
D
S
S
E
I
-------
I
N
T
L
A
GG
G
V
S
T
V
G
Y
A
S
E
----------------
G
V
T
A
H
T
T
N
----
R
I
T
------------------
S
L
V
R
K
A
A
L
G
R
------
L
--
T
L
PCEIE
G
A
E
--
R
A
-----
L
L
V
L
A
G
P
---------
P
E
H
----------------------------------------------------------------------
L
N
R
K
G
I
E
R
G
R
K
W
I
---
E
E
Q
T
G
S
M
E
V
R
G
G
D
Y
P
---
I
P
G
A
---
E
-------
K
V
A
G
-----
V
I
L
L
S
G
V
T
N
V
P
--------------------
R
I
K
E
L
Q
Q
V
--
A
I
E
A
Q
D
---------
33
Fugue
61.99
13%
-137
- C2 -
4WGV
-
?
A:
[45-439]
---------------------------------------------------------------
V
G
Y
M
D
P
G
--
N
W
I
T
S
------
M
Q
G
G
-
A
Q
Y
G
Y
T
---
L
L
F
V
----
I
L
I
S
-----------
S
L
A
A
M
L
L
Q
-----
S
M
T
-----
V
R
L
G
I
A
T
G
----------------------------------------------------------------------------------
K
D
L
A
Q
M
T
R
H
F
L
S
K
P
V
A
--------
I
I
F
W
I
I
A
E
-
L
A
I
I
A
---------
T
D
I
A
E
V
I
G
S
A
I
A
L
D
L
--
I
F
G
I
-----
P
-
L
--
I
--
V
--
G
A
L
I
T
V
F
D
--
V
F
L
L
L
F
I
M
R
F
G
F
R
K
I
E
A
I
V
G
----------------------
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
S
--
P
Q
L
-
T
---
D
-
I
-------------
L
N
G
F
V
P
--
H
K
---
E
I
V
T
N
--------
Q
G
I
L
----
Y
-
I
-
A
L
G
----------
I
-
I
G
---
A
---
T
---
I
M
-----
P
-
H
N
L
---
Y
L
H
S
-
S
I
V
Q
S
R
-
K
Y
D
R
--------
H
D
-------
N
E
-
E
K
A
Q
A
I
K
Y
A
T
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
T
L
G
A
A
L
--
F
F
G
--------
T
K
T
N
D
-------------
L
G
G
F
Y
D
L
-----------
Y
---------------
H
A
L
K
-
T
E
P
V
L
GA
T
L
G
G
V
--------
M
--
S
---------------
T
L
F
A
V
A
L
L
A
S
-
G
Q
N
S
T
---
I
T
G
T
L
A
-------
G
Q
I
V
M
---
E
G
F
L
R
L
S
I
P
----------------
N
W
L
R
R
L
I
T
----
R
S
L
------------------
A
V
I
P
V
I
I
C
L
I
------
I
--
F
K
-----
G
N
S
--
E
K
-----
I
E
Q
L
L
V
F
---------
S
Q
V
F
L
S
I
A
L
-------------------------------------------------------------------------------------------
P
F
S
L
---
I
P
L
Q
--
L
A
-------
T
S
N
K
-----
K
L
M
G
P
F
I
N
K
T
W
--------------------
V
N
I
I
S
W
T
L
--
I
V
I
L
S
G
L
N
V
Y
-----
26
Fugue
60.32
17%
-115
- C3 -
4RKN
14
MCCA_WOLSU
A:
[43-702]
MQMT
K
E
A
R
E
I
I
A
HPKGTKESRGV-------
I
S
L
Q
D
Y
I
V
E
E
Q
A
M
Y
D
W
L
F
K
N
H
P
I
F
T
K
Y
-------
G
G
K
T
V
G
--
K
L
V
V
K
D
RGEEW
I
E
E
G
R
G
N
D
F
S
K
---
A
S
K
R
SGGE
G
F
S
S
-----------
M
M
Y
R
V
A
R
N
-----
S
T
L
-----
Q
Y
P
N
K
F
I
G
P
E
K
C
G
E
C
H
P
A
Q
Y
E
T
W
S
R
S
--------------------
R
-
H
A
T
------
T
I
RFPGEHPEVNNKLNDPVFDKDTASILPQGIT
P
D
V
V
Y
C
T
V
G
H
I
R
T
K
F
G
--------
F
F
D
A
W
L
L
R
-
G
T
Y
H
V
E
GGLLK---
N
G
T
G
Q
I
V
A
G
G
N
Q
W
Q
R
--
T
W
A
L
-----
N
-------------
L
S
P
----
E
V
A
K
K
I
K
K
W
V
P
D
F
P
V
T
L
E
E
Y
GDNGGYVRG
L
A
S
Y
AAKYKKSMS
F
Q
A
S
T
S
Y
C
E
V
C
H
P
W
K
F
D
F
--
K
N
E
-
S
---
E
-
F
-------------
Y
A
A
L
G
N
--
A
K
---
E
L
Q
K
H
----------
T
I
----
S
-
K
-
G
V
S
----------
C
-
E
E
---
C
---
H
--
G
A
G
GHLEG
G
-
S
G
L
---
L
I
S
N
-
C
E
R
C
H
Q
-
R
F
S
Y
--------
S
P
-------
D
L
-
M
R
N
N
P
L
N
A
G
K
P
D
L
A
L
S
S
K
F
K
S
M
G
P
G
-
C
-
G
S
E
G
S
Q
--
T
Y
F
--------
T
A
H
Y
E
-------------
K
G
M
R
C
A
T
-----------
C
HDPHDVTGN
V
T
G
E
KG
I
K
G
V
-
S
Y
N
S
E
---
Q
G
Y
L
--------
S
--
S
L
Y
S
K
P
KLKKE
C
T
D
C
H
K
E
Q
A
Y
I
Q
S
K
A
-
D
T
H
S
K
---
N
S
C
A
S
C
HMPFMMS
C
E
N
F
Y
---
A
I
Q
F
Q
D
Q
A
G
FDTQRRAHIW
K
I
D
V
D
P
A
R
K
S
L
V
A
G
----
S
T
S
KDPRDGKD
W
H
F
E
R
N
EEG
R
N
F
V
D
L
M
W
A
C
A
------
R
--
T
T
-----
W
A
D
--
K
D
-----
Q
A
E
A
K
G
C
HSPVVSELK
E
T
L
H
F
K
D
Q
K
Q
---
V
Y
N
----
E
V
M
G
W
Q
T
P
V
K
D
K
---------------
F
-------------------
T
----
Q
V
K
V
G
I
Q
G
L
Y
S
L
L
E
---
V
K
K
L
A
P
S
D
K
T
R
V
Y
E
L
---
I
E
K
A
Q
D
T
V
-------
D
L
I
E
K
D
GSW
G
M
H
G
F
K
Y
T
K
Q
R
--------------------
L
D
A
A
V
E
Y
I
--
N
E
A
Q
R
I
M
K
K
S
L
----
29
Fugue
58.09
12%
-163
- C3 -
3ZHE
-
?
A:
[2-400]
----Q
K
S
D
E
V
T
-------------------
E
K
F
K
R
Y
C
N
Q
L
E
K
Y
G
-----
Q
T
E
N
V
H
S
----------------
P
V
M
A
M
------
L
R
R
K
-
G
R
K
Q
L
I
---
E
I
M
K
----
R
D
G
D
-----------
C
--
T
S
S
I
N
-----
K
L
W
-----
I
V
G
-------------------
Y
Y
H
P
F
-------------------
Q
-
F
F
I
------
R
D
-------------------------------
K
E
---
K
N
M
A
I
A
V
L
L
T
M
--------
F
C
G
E
L
Q
E
M
-
L
S
L
P
-----------------------------
D
D
-----
K
-
Y
--
P
--
A
--
L
W
N
M
Y
I
----
G
D
F
H
R
Y
M
P
D
E
E
I
Q
K
C
L
A
V
G
Y
----------------------
Y
S
R
A
I
D
L
D
P
-------------------
N
-
Q
-------------
G
R
A
F
H
V
--
L
A
---
G
L
R
A
D
--------
L
---------
N
-
V
A
Q
----------
K
-
L
R
---
L
---
M
--
I
L
G
-----
Q
-
L
A
D
---
A
P
Y
K
-
K
G
T
E
L
L
-
E
Y
L
K
--------
F
P
-------
Q
K
-
E
S
T
D
K
L
M
V
D
F
V
I
W
A
L
N
E
K
S
K
R
M
D
Y
Q
-
M
T
G
I
K
I
V
N
--
E
F
K
--------
A
E
I
E
Q
-------------
K
---------------------------------
L
E
F
D
-
W
S
L
I
M
---
S
T
C
R
--------
L
--
A
---------------
S
K
L
A
M
K
K
F
G
---
F
Q
Q
F
---
Y
N
C
F
D
T
-------
I
S
T
L
Y
---
I
T
I
Y
S
R
T
I
S
----------------
S
K
C
L
L
A
------
E
A
I
------------------
S
W
I
S
D
S
A
E
I
L
------
G
--
H
L
-----
D
E
Q
--
K
-------------------------------
N
---
E
P
H
----
F
Q
K
L
S
V
F
A
K
T
K
----------------
W
-------------------
N
----
E
L
N
D
L
V
M
N
H
I
N
S
V
F
TSM
S
L
T
I
N
P
S
I
S
M
T
S
F
L
L
NGP
I
S
E
P
--
N
V
-------
E
F
L
S
-----
Q
L
I
N
Y
L
V
S
V
E
F
--------------------
P
P
M
E
I
I
H
D
--
R
E
E
S
G
P
L
L
R
R
I
N---
20
HHSearch
57.56
13%
-163
- C2 -
3GIA
5
Y609_METJA
A:
[5-300]
-----------------------------------------------------------------
N
K
K
L
S
--
L
W
E
A
V
------
S
M
A
V
-
G
V
M
I
G
A
---
S
I
F
S
----
I
F
G
V
-----------
G
A
K
I
A
G
R
N
-----
L
-
P
-----
E
T
F
--
I
L
S
-
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
A
K
I
-------------------
V
-
S
N
A
------
G
P
-------------------------------
I
A
F
I
H
K
A
I
-
G
-
D
N
I
I
T
--------
G
A
L
S
I
L
L
W
-
M
S
Y
V
I
---------
S
I
A
L
F
A
K
G
F
A
G
Y
F
L
P
--
L
I
N
A
-----
P
-
I
N
T
F
N
I
A
--
I
T
E
I
G
I
----
V
A
F
F
T
A
L
N
F
F
G
S
K
A
V
G
R
A
E
F
----------------------
F
I
V
L
V
K
L
L
I
L
G
L
F
I
F
A
G
L
--
I
T
I
-
H
-----
P
-------------
S
Y
V
------------
I
P
D
--------
L
-
A
P
----
S
-
A
-
V
S
G
----------
M
-
I
F
---
A
---
S
----
A
-----
I
-
F
F
L
---
S
Y
M
G
-
F
G
V
I
T
N
-
A
S
E
H
--------
I
E
-------
N
P
K
K
N
V
P
R
A
I
F
I
S
I
L
I
V
M
F
V
Y
V
G
V
A
I
S
A
-
I
---
G
N
L
P
---
I
D
--------
E
L
I
K
A
-------------
S
E
N
A
L
A
V
-----------
A
---------------
A
K
P
F
-
L
G
N
L
G
---
F
L
L
I
--------
S
--
I
---------------
G
A
L
F
S
I
S
S
A
M
-
N
A
T
I
Y
---
G
G
A
N
V
A
-------
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.50
24%
-132
- C2 -
3DH4
3
?
A:
[118-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
-------------------------------
P
E
F
V
E
K
R
F
N
K
K
--
L
K
T
--------
I
L
A
V
F
W
I
S
-
L
Y
I
F
V
---------
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
--
I
L
G
I
-----
P
-
L
--
M
--
Y
--
S
I
L
G
L
A
----
L
F
A
L
V
Y
S
I
------
V
V
W
T
D
V
----------------------
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
--
S
F
I
-
G
---
G
-
T
DG
W
F
A
G
V
S
K
M
V
D
A
A
P
G
H
F
E
MI
L
D
---
Q
S
N
P
Q
--------
Y
M
N
L
----
P
-
G
-
I
A
V
----------
L
-
I
G
G
L
W
V
---
A
--
N
L
Y
-----
Y
-
W
G
F
---
N
Q
Y
-----
I
I
Q
-
R
T
L
A
--------
A
K
-------
S
V
-
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
-
I
--
A
A
Y
---------------
V
I
T
S
D
-------------
P
Q
L
M
A
S
L
GDIAATNLPSA
A
---------------
N
A
D
K
-
A
Y
P
W
L
---
T
Q
F
L
PVG
V
K
G
V
V
F
--
A
---------------
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
---
S
T
A
T
I
F
-------
T
M
D
I
Y
---
K
E
Y
I
S
P
D
S
G
----------------
D
H
K
L
V
N
V
G
----
R
T
A
------------------
A
V
V
A
L
I
I
A
C
L
------
I
--------------
A
P
-----
M
L
G
G
I
G
Q
---------
A
F
Q
Y
I
Q
E
Y
T
G
LV
S
P
G
I
L
A
V
F
L
L
G
L
F
W
K
K
T
T
S
----------------
K
-------------------
G
----
A
I
I
G
V
V
-------------------------------------------------------------------------------------------------------------
30
Fugue
55.93
14%
-129
- C3 -
1JKM
-
?
A:
[13-370]
--------------------------------------------------------------------------------------------
P
G
---
R
L
G
D
----
E
S
S
G
-----------
P
R
T
D
P
R
F
S
-----
P
A
M
-----
V
E
A
L
A
T
F
G
------
L
D
A
V
A
A
A
P
P
V
S
A
S
-------------------
D
-
D
L
P
------
T
V
-------------------------------
L
A
A
V
G
A
S
H
D
G
F
Q
A
V
Y
D
--------
S
I
A
L
D
L
P
T
-
D
R
D
D
V
---------
E
T
S
T
E
T
I
L
G
V
D
--------
G
N
-----
E
-
I
--
T
--
L
--
H
V
F
R
P
A
GVE
G
V
L
P
G
L
V
Y
T
H
G
G
G
M
T
I
L
T
T
D
N
----------------------
R
V
H
R
R
W
C
T
D
L
A
A
A
G
S
V
V
V
--
M
V
D
-
F
---
R
-
N
-------------
A
W
T
A
E
G
--
H
H
---
P
F
P
S
G
--------
V
E
D
C
----
L
-
A
-
A
V
L
----------
W
-
V
D
---
E
--------------------------------------------------------------
H
R
E
S
L
G
L
S
G
V
V
V
Q
G
E
S
-------
G
G
G
N
L
A
I
--
A
T
T
--------
L
L
A
K
R
-------------
R
G
R
L
D
A
I
-----------
D
---------------
G
V
Y
A
-
S
I
P
Y
I
---
S
G
G
Y
--------
A
WD
H
---------------
E
R
R
L
T
E
L
P
S
L
-
V
E
N
D
G
---
Y
F
I
E
N
G
-------
G
M
A
L
L
---
V
R
A
Y
D
P
T
G
E
----------------
H
A
E
--------------------------------------------------------
D
P
I
--
A
W
-----
P
Y
F
A
S
E
D
---------
E
L
R
G
L
P
-------
P
F
V
----
V
A
V
N
E
L
D
P
L
R
D
----------------
E
-------------------
G
----
I
A
F
A
R
R
L
A
R
A
G
V
D
V
---
A
A
R
V
N
I
G
L
V
H
G
A
D
V
I
---
F
R
H
W
---------------------------
L
P
A
A
--------------------
L
E
S
T
V
R
D
V
--
A
G
F
A
A
D
R
A
R
L
R
----
18
HHSearch
51.16
13%
-152
- C2 -
4WGV
-
?
A:
[45-372]
----------------------------------------------------------------------------------------
V
G
Y
M
D
P
---
G
N
W
I
----
T
S
M
Q
-----------
G
G
A
Q
Y
G
Y
T
-----
L
L
F
-----
V
I
L
I
S
S
L
A
A
M
L
L
Q
----
S
M
T
V
R
L
G
I
A
T
---------------------
G
K
-------
D
L
-------------------------------
A
Q
M
T
R
H
F
L
-
S
--
K
P
V
A
--------
I
I
F
W
I
I
A
E
-
L
A
I
I
A
---------
T
D
I
A
E
V
I
G
S
A
I
A
L
D
L
--
I
F
G
I
-----
P
-
L
--
I
--
V
--
G
A
L
I
T
V
----
F
D
V
F
L
L
L
F
I
M
R
F
-
G
F
---
R
K
----------------------
I
E
A
I
V
G
T
L
I
F
T
V
L
A
I
F
V
F
E
V
F
I
S
S
P
---
Q
-
L
-------------
T
D
I
L
N
G
--
F
V
------
P
H
--------
K
E
I
V
----
T
-
N
-
Q
G
I
----------
L
-
Y
I
---
A
---
L
--
G
I
I
-----
G
-
A
T
I
M
P
H
N
L
Y
L
-
H
S
S
I
V
Q
S
R
K
Y
D
--------
R
H
DNEEK
A
Q
A
I
-
K
Y
A
T
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
--
L
L
T
-
L
G
A
A
L
F
F
G
--
T
K
T
--------
N
D
L
G
G
-------------
F
Y
D
L
Y
H
A
L
K
T
EP------
V
---------------
L
G
A
T
-
L
G
G
V
M
---
S
T
L
F
--------
A
--
V
---------------
A
L
L
A
S
G
Q
N
S
T
-
I
T
G
T
L
---
A
-
G
Q
I
V
-------
M
E
G
F
L
---
R
L
S
I
P
--------------------
N
W
L
R
R
L
I
T
----
R
S
L
------------------
A
V
I
P
V
I
I
C
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
50.50
10%
-152
- C2 -
3L1L
2
ADIC_ECO57
A:
[7-302]
-----------------------------------------------------------------
A
H
K
V
G
--
L
I
P
V
T
------
L
M
V
S
-
G
A
I
M
G
S
---
G
V
F
L
-----
L
P
A
-----------
N
L
A
S
T
G
G
I
-----
A
I
Y
G
----
W
L
V
T
I
I
G
-----
A
L
G
L
S
M
V
Y
A
K
M
S
F
L
D
-------------------
P
-
S
P
G
------
G
S
-------------------------------
Y
A
Y
A
R
R
C
F
-
G
--
P
F
L
G
--------
Y
Q
T
N
V
L
Y
W
-
L
A
C
W
I
---------
G
N
I
A
M
V
V
I
G
V
G
Y
L
S
Y
--
F
F
P
I
-----
L
K
D
P
-
W
--
V
L
T
I
T
C
V
V
V
----
L
W
I
F
V
L
L
N
I
V
G
P
K
M
I
T
R
V
Q
A
----------------------
V
A
T
V
L
A
L
I
P
I
V
G
I
A
V
F
G
W
--
F
W
F
-
R
-----
G
-------------
E
T
Y
-
M
-----------
A
-------------------------------------
A
---
I
---
Q
S
-
T
L
N
-----
V
-
T
L
W
---
S
F
I
G
-
V
E
S
A
S
V
-
A
A
G
V
--------
V
K
-------
N
P
K
R
N
V
P
I
A
T
I
G
G
V
L
I
A
A
V
C
Y
V
L
S
T
T
A
I
-
M
G
---
M
I
P
---
N
A
---------
A
L
R
V
-------------
S
A
S
P
F
G
D
-----------
A
---------------
A
R
M
A
-
L
G
D
T
A
---
G
A
I
V
--------
S
--
F
---------------
C
A
A
A
G
C
L
G
S
L
-
G
G
W
T
L
---
L
A
G
Q
T
A
-------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
40.24
23%
-116
- C2 -
1GZV
1
G6PI_PIG
A:
[143-245]
---------------------------------------------
Y
S
G
K
S
I
T
D
V
I
N
I
G
-----
I
G
G
S
D
L
G
--
P
L
M
V
T
------
E
A
L
K
-
P
Y
S
A
E
G
P
R
V
W
F
V
S
----
N
I
D
G
-----------
T
H
I
A
K
T
L
A
-----
T
L
-------------
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
-------------------
T
-
N
A
E
------
T
A
-------------------------------
K
E
W
F
L
Q
S
A
K
D
P
S
A
V
A
K
--------
H
F
V
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
38.62
23%
-115
- C2 -
1GZD
1
G6PI_PIG
A:
[143-245]
---------------------------------------------
Y
S
G
K
S
I
T
D
V
I
N
I
G
-----
I
G
G
S
D
L
G
--
P
L
M
V
T
------
E
A
L
K
-
P
Y
S
A
E
G
P
R
V
W
F
V
S
----
N
I
D
G
-----------
T
H
I
A
K
T
L
A
-----
T
L
-------------
N
P
E
S
S
L
F
I
I
A
S
K
T
F
T
T
Q
E
T
I
-------------------
T
-
N
A
E
------
T
A
-------------------------------
K
E
W
F
L
Q
S
A
K
D
P
S
A
V
A
K
--------
H
F
V
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
35.35
16%
-128
* C3 *
3PMK
-
?
N:
[6-35]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
R
E
Y
L
K
S
Y
S
R
L
D
-------------------
Q
-
A
V
G
------
E
I
-------------------------------
D
E
I
E
A
Q
R
A
E
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
34.01
19%
-243
- C2 -
4US3
3
?
A:
[298-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
D
-----------
I
---------------
F
D
S
I
R
L
G
P
I
V
---
G
I
A
F
--------
F
--
I
---------------
L
L
G
A
A
A
L
S
S
A
-
V
S
L
L
E
---
V
P
V
A
Y
F
-------
M
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
29.91
0%
-63
- C2 -
4DJK
-
GADC_ECOLI
A:
[56-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
G
L
C
A
A
E
M
A
T
V
D
-------------------
G
W---------
G
V
-------------------------------
F
A
W
V
S
N
T
L
-
G
--
P
R
W
G
--------
F
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
28.38
34%
-127
* C4 *
5HCE
-
?
B:
[15-65]
---------------------------------------------------------------------------------------------------------------------------------------------------
V
G
A
S
E
N
I
V
I
---
Q
V
Y
G
Y
T
E
A
F
-------------------
D
-
A
T
I
------
S
I
-------------------------------
K
S
Y
P
D
K
K
F
S
Y
S
S
G
H
V
H
--------
L
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------